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Journal articles on the topic 'Technology cell therapy'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

NAGAI, Moeto. "Massively Parallel Single-Cell Processing Technology for Cell Therapy." Proceedings of Mechanical Engineering Congress, Japan 2022 (2022): F221–01. http://dx.doi.org/10.1299/jsmemecj.2022.f221-01.

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Ohki, Takeshi, and Masakazu Yamamoto. "Esophageal regenerative therapy using cell sheet technology." Regenerative Therapy 13 (March 2020): 8–17. http://dx.doi.org/10.1016/j.reth.2020.04.009.

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3

Dennett, R., A. Gibbons, and V. Pimpaneau. "Successful technology transfer for cell therapy products." Cytotherapy 16, no. 4 (2014): S107. http://dx.doi.org/10.1016/j.jcyt.2014.01.396.

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4

Rao, Chethana, Pushpendra Mani Mishra, Aditya Yadav, and Chayan Kanti Nandi. "Cancer Cell Membrane Technology for Cancer Therapy." ChemNanoMat 6, no. 12 (2020): 1712–29. http://dx.doi.org/10.1002/cnma.202000482.

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Kawamura, Takuji. "Cardiac Regeneration Therapy Using Cell Sheet Technology." Drug Delivery System 40, no. 2 (2025): 127–31. https://doi.org/10.2745/dds.40.127.

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6

YAMASHITA, Toru, and Koji ABE. "Recent Progress in Cell Reprogramming Technology for Cell Transplantation Therapy." Neurologia medico-chirurgica 56, no. 3 (2016): 97–101. http://dx.doi.org/10.2176/nmc.ra.2015-0309.

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7

Deepak Goyal, Anjali. "Cell Based Therapy for Articular Cartilage Regeneration; Past, Present & Future." Clinical Pathology & Research Journal 8, no. 1 (2024): 1–12. https://doi.org/10.23880/cprj-16000197.

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The articular cartilage around the knee joint is specialized for load bearing along with the transmission of sheer forces to the underlying bone. A damage to the cartilage following injuries, loading & aging can lead to the development of degenerative joint disorders (osteoarthritis). Treatment of large articular cartilage defects is technically difficult and complex, often accompanied by failure. Articular cartilage cannot repair itself after injury due to a lack of blood vessels, lymph, and nerves. The repair has been attempted by the various cartilage repair surgeries with a varying suc

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Mount, Natalie M., Stephen J. Ward, Panos Kefalas, and Johan Hyllner. "Cell-based therapy technology classifications and translational challenges." Philosophical Transactions of the Royal Society B: Biological Sciences 370, no. 1680 (2015): 20150017. http://dx.doi.org/10.1098/rstb.2015.0017.

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Cell therapies offer the promise of treating and altering the course of diseases which cannot be addressed adequately by existing pharmaceuticals. Cell therapies are a diverse group across cell types and therapeutic indications and have been an active area of research for many years but are now strongly emerging through translation and towards successful commercial development and patient access. In this article, we present a description of a classification of cell therapies on the basis of their underlying technologies rather than the more commonly used classification by cell type because the

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9

Hashemi, Maryam, and Fatemeh Kalalinia. "Application of encapsulation technology in stem cell therapy." Life Sciences 143 (December 2015): 139–46. http://dx.doi.org/10.1016/j.lfs.2015.11.007.

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Rabanel, Jean-Michel, Xavier Banquy, Hamza Zouaoui, Mohamed Mokhtar, and Patrice Hildgen. "Progress technology in microencapsulation methods for cell therapy." Biotechnology Progress 25, no. 4 (2009): 946–63. http://dx.doi.org/10.1002/btpr.226.

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DRUMMOND, ROBERT J., TILO KUNATH, P. JOSEPH MEE, and JAMES A. ROSS. "Induced pluripotent stem cell technology and stem cell therapy for diabetes." Experimental and Therapeutic Medicine 2, no. 1 (2010): 3–7. http://dx.doi.org/10.3892/etm.2010.173.

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Uscanga-Palomeque, Ashanti Concepción, Ana Karina Chávez-Escamilla, Cynthia Aracely Alvizo-Báez, et al. "CAR-T Cell Therapy: From the Shop to Cancer Therapy." International Journal of Molecular Sciences 24, no. 21 (2023): 15688. http://dx.doi.org/10.3390/ijms242115688.

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Cancer is a worldwide health problem. Nevertheless, new technologies in the immunotherapy field have emerged. Chimeric antigen receptor (CAR) technology is a novel biological form to treat cancer; CAR-T cell genetic engineering has positively revolutionized cancer immunotherapy. In this paper, we review the latest developments in CAR-T in cancer treatment. We present the structure of the different generations and variants of CAR-T cells including TRUCK (T cells redirected for universal cytokine killing. We explain the approaches of the CAR-T cells manufactured ex vivo and in vivo. Moreover, we

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13

Gerlach, J. C., and K. Zeilinger. "Adult Stem Cell Technology - Prospects for Cell Based Therapy in Regenerative Medicine." International Journal of Artificial Organs 25, no. 2 (2002): 83–90. http://dx.doi.org/10.1177/039139880202500202.

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14

Zhang, Hu, David E. Kent, Mohammad Albanna, et al. "Bioreactor Technology for Cell Therapy Manufacturing in Regenerative Medicine." Current Stem Cell Reports 7, no. 4 (2021): 212–18. http://dx.doi.org/10.1007/s40778-021-00200-x.

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15

Belhaj, Marwa, Vinal Menon, Barbel Rohrer, and Jay Potts. "Alginate Microcapsule Technology and Impacts on Cell Therapy Development." Microscopy and Microanalysis 23, S1 (2017): 1214–15. http://dx.doi.org/10.1017/s1431927617006730.

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16

Xia, Yueting. "New Development of Vaccine Technology in Tumor Therapy." Theoretical and Natural Science 59, no. 1 (2024): 269–76. http://dx.doi.org/10.54254/2753-8818/59/20241442.

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Abstract. Cancer vaccines are a crucial component of tumors immunotherapy, offering the advantage of minimizing adverse reactions to induce tumor regression. They also enable the establishment of lasting anti-tumor memory. Recent years have seen significant breakthroughs in cancer vaccines, including the customization of personalized vaccines and the transition from passive immunization to active treatment. Currently, most cancer vaccine future goals focus on improving cost and efficiency such as combining immunology and bioinformatics to predict more accurate vaccine epitopes. This paper focu

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Zong, Jiepu, and Yan-Ruide Li. "iPSC Technology Revolutionizes CAR-T Cell Therapy for Cancer Treatment." Bioengineering 12, no. 1 (2025): 60. https://doi.org/10.3390/bioengineering12010060.

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Chimeric Antigen Receptor (CAR)-engineered T (CAR-T) cell therapy represents a highly promising modality within the domain of cancer treatment. CAR-T cell therapy has demonstrated notable efficacy in the treatment of hematological malignancies, solid tumors, and various infectious diseases. However, current CAR-T cell therapy is autologous, which presents challenges related to high costs, time-consuming manufacturing processes, and the necessity for careful patient selection. A potential resolution to this restriction could be found by synergizing CAR-T technology with the induced pluripotent

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18

Hasenmayer, D., A. Lamontagne, L. Lewitt, et al. "Implementation of new cell washing technology in an academic cell therapy manufacturing laboratory." Cytotherapy 23, no. 5 (2021): S165. http://dx.doi.org/10.1016/s1465324921005570.

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19

Del'Guidice, Thomas, Jean-Pascal Lepetit-Stoffaes, Joannie Roberge, et al. "603. Feldan Shuttle - Advanced Protein Delivery Technology for Cell Therapy." Molecular Therapy 24 (May 2016): S239. http://dx.doi.org/10.1016/s1525-0016(16)33411-6.

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Staquicini, Fernanda I., Richard L. Sidman, Wadih Arap, and Renata Pasqualini. "Phage display technology for stem cell delivery and systemic therapy." Advanced Drug Delivery Reviews 62, no. 12 (2010): 1213–16. http://dx.doi.org/10.1016/j.addr.2010.09.014.

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21

Boudousquié, C., S. Dellac, R. Turrini, Y. Pierson, and L. Henry. "CAR-T Manufacturing Using Next-generation Cell Therapy Manufacturing Technology." Cytotherapy 27, no. 5 (2025): S166. https://doi.org/10.1016/j.jcyt.2025.03.333.

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何弘能, 何弘能. "國內細胞治療的現況、限制與風險". 醫療品質雜誌 16, № 3 (2022): 072–75. http://dx.doi.org/10.53106/199457952022051603010.

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<p>隨著醫療科技的快速突破，細胞或基因改造過的細胞治療、再生醫療可解決許多未被滿足的醫療需求，再加上商機無限，已成為近10年進展最快的一種治療方向。細胞治療具有許多限制及挑戰，從研發、製備場所、供應、臨床試驗、治療到追蹤，皆與藥物管理有很大差異，無法依相同法規或規範執行。而法規齊備、專業人才培育與延攬、降低費用及結合AI科技等，都是細胞治療成功的關鍵。如何讓有需求的病人能順利、安心的接受治療，而不只是「富人醫療」，是我們最大且重要的期望及目標。</p> <p>&nbsp;</p><p>As medical technology advances rapidly, cell therapy and regenerative medicine involving cells or genetically-modified cells can address many unmet medical needs. They have infinite commercial opportunities and have become the one of the most rapidly developing directions for therapy in the last decade. Cell therapy is

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23

Oppenheimer, Steven B. "Classic Experiments in Education Technology." Frontiers in Education Technology 6, no. 1 (2023): p26. http://dx.doi.org/10.22158/fet.v6n1p26.

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Classic experiments in Biomedicine are presented that inspire students to enthusiastically continue in this field, written by a U.S. Presidential Award winning, American Association for the Advancement of Science Fellow. Four experiments are selected: the structure of DNA, the structure of the cell membrane, sugars in cell adhesion, and unconventional dealing with a deadly cancer problem. Papers, written mostly by students, from the author’s lab are also included that support the concept that students will enter a science research field if they are introduced to it by easy to read, enjoyable,

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24

Zhu, Fengchang, Yan Pan, Chengyin Liu, Huaji Zhang, Yongjun Wang, and Liping Bai. "Studying the Global Progress and Regulatory Landscape of Stem Cell Therapy Research." Journal of Modern Biology and Drug Discovery 4 (January 15, 2025): 1. https://doi.org/10.53964/jmbdd.2025001.

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Objective: Stem cell therapy has emerged as a pioneering front in the biomedical domain, characterized by its rapid strides in innovation and progress. Such advancements hold profound implications for public health. Notably, Europe, the United States, Japan, and China have all crafted comprehensive regulatory frameworks to expedite the fruition of stem cell therapy. This article meticulously scrutinizes and evaluates the progression of clinical trials in cell therapy across major global jurisdictions. It delineates the trajectory of regulatory evolution in Europe, the United States, Japan, and

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25

Zia, Silvia, Giulia Martini, Valeria Pizzuti, et al. "A New Predictive Technology for Perinatal Stem Cell Isolation Suited for Cell Therapy Approaches." Micromachines 12, no. 7 (2021): 782. http://dx.doi.org/10.3390/mi12070782.

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The use of stem cells for regenerative applications and immunomodulatory effect is increasing. Amniotic epithelial cells (AECs) possess embryonic-like proliferation ability and multipotent differentiation potential. Despite the simple isolation procedure, inter-individual variability and different isolation steps can cause differences in isolation yield and cell proliferation ability, compromising reproducibility observations among centers and further applications. We investigated the use of a new technology as a diagnostic tool for quality control on stem cell isolation. The instrument label-

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26

Martin, Risto, Rui Lei, Yida Zeng, et al. "Membrane Applications in Autologous Cell Therapy." Membranes 12, no. 12 (2022): 1182. http://dx.doi.org/10.3390/membranes12121182.

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Stem cell and cell therapies, particularly autologous cell therapies, are becoming a common practice. However, in order for these technologies to achieve wide-scale clinical application, the prohibitively high cost associated with these therapies must be addressed through creative engineering. Membranes can be a disruptive technology to reshape the bioprocessing and manufacture of cellular products and significantly reduce the cost of autologous cell therapies. Examples of successful membrane applications include expansions of CAR-T cells, various human stem cells, and production of extracellu

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27

Nakamura, Kentaro. "CellSaic, A Cell Aggregate-Like Technology Using Recombinant Peptide Pieces for MSC Transplantation." Current Stem Cell Research & Therapy 14, no. 1 (2019): 52–56. http://dx.doi.org/10.2174/1574888x13666180912125157.

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In the field of stem cell therapy, research on the application of mesenchymal stem cells (MSCs) has flourished because of the various functions. On the other hand, research on the method of cell transplantation has developed from the administration of cell suspensions to cell-sheet engineering and 3D technology. In the trend, a cell transplantation platform named CellSaic, which is a combination of xeno-free recombinant scaffolds in a cell aggregate-like shape, was developed. CellSaic is the cell transplantation platform that can prevent the central necrosis within cell aggregates by arranging

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28

Ravindranathan, Sruthi, Mohammad Raheel Jajja, Alexandra Waller, et al. "Personalized T cell therapy for metastatic colon cancer." Journal of Clinical Oncology 37, no. 15_suppl (2019): e15183-e15183. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e15183.

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e15183 Background: Current immunotherapies fail to benefit patients with colon cancer, largely due to high molecular heterogeneity and low frequencies of tumor infiltrating lymphocytes. In this study, we are addressing this limitation via a novel technology to expand patient tumor specific T cells ex-vivo, using patient’s matched tumor and peripheral blood mononuclear cells (PBMCs). This technology utilizes tumor membrane vesicles (TMVs) made from excised tumor tissue, as a source of tumor associated antigens, and further modified to express IL-12 and B7-1 for ex-vivo expansion of tumor specif

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29

Campos-Gonzalez, Gerard, Javier Martinez-Picado, Talia Velasco-Hernandez, and Maria Salgado. "Opportunities for CAR-T Cell Immunotherapy in HIV Cure." Viruses 15, no. 3 (2023): 789. http://dx.doi.org/10.3390/v15030789.

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Chimeric antigen receptor (CAR) technology is having a huge impact in the blood malignancy field and is becoming a well-established therapy for many types of leukaemia. In recent decades, efforts have been made to demonstrate that CAR-T cells have potential as a therapy to achieve a sterilizing cure for human immunodeficiency virus (HIV) infection. However, translation of this technology to the HIV scenario has not been easy, as many challenges have appeared along the way that hinder the consolidation of CAR-T cells as a putative therapy. Here, we review the origin and development of CAR-T cel

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30

Grabowski, Gregory, Myriam Golembo, and Yoseph Shaaltiel. "Taliglucerase alfa: an enzyme replacement therapy using plant cell expression technology." Molecular Genetics and Metabolism 111, no. 2 (2014): S49. http://dx.doi.org/10.1016/j.ymgme.2013.12.103.

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31

Grabowski, Gregory A., Myriam Golembo, and Yoseph Shaaltiel. "Taliglucerase alfa: An enzyme replacement therapy using plant cell expression technology." Molecular Genetics and Metabolism 112, no. 1 (2014): 1–8. http://dx.doi.org/10.1016/j.ymgme.2014.02.011.

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32

Baradez, M., D. Biziato, E. Hassan, and D. Marshall. "Raman spectroscopy as a process analytical technology for cell therapy bioprocessing." Cytotherapy 20, no. 5 (2018): S105. http://dx.doi.org/10.1016/j.jcyt.2018.02.308.

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33

Vissers, Caroline, Guo-li Ming, and Hongjun Song. "Nanoparticle technology and stem cell therapy team up against neurodegenerative disorders." Advanced Drug Delivery Reviews 148 (August 2019): 239–51. http://dx.doi.org/10.1016/j.addr.2019.02.007.

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34

Aghamiri, Sara Sadat, and Rada Amin. "The Potential Use of Digital Twin Technology for Advancing CAR-T Cell Therapy." Current Issues in Molecular Biology 47, no. 5 (2025): 321. https://doi.org/10.3390/cimb47050321.

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CAR-T cell therapy is a personalized immunotherapy that has shown promising results in treating hematologic cancers. However, its therapeutic efficacy in solid cancers is often limited by tumor evasion mechanisms, resistance pathways, and an immunosuppressive tumor microenvironment. These challenges highlight the need for advanced predictive models to better capture the intricate interactions between CAR-T cells and tumors to enhance their potential. Digital Twins represent a transformative approach for optimizing CAR-T cell therapy by providing a virtual representation of the therapy-tumor tr

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35

Wang, Xuaner. "Stem Cell Therapy in Diabetes: Prospects and Challenges." Theoretical and Natural Science 111, no. 1 (2025): 108–12. https://doi.org/10.54254/2753-8818/2025.au23386.

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Diabetes mellitus has a serious impact on patients' health and quality of life. Chronic hyperglycemia can lead to a series of acute and chronic complications, such as diabetic foot, diabetic nephropathy, diabetic retinopathy, diabetic neuropathy and cardiovascular disease. In addition, diabetes disrupts the pre-existing organized capacity for wound healing and impedes wound healing. Traditional ways of treating diabetes, such as oral hypoglycemic agents and insulin injections. Although these methods are effective, there is no rooted cure and there is a burden of life and risk of hypoglycemia.

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36

Chang, Yujung, Sungwoo Lee, Jieun Kim, et al. "Gene Therapy Using Efficient Direct Lineage Reprogramming Technology for Neurological Diseases." Nanomaterials 13, no. 10 (2023): 1680. http://dx.doi.org/10.3390/nano13101680.

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Gene therapy is an innovative approach in the field of regenerative medicine. This therapy entails the transfer of genetic material into a patient’s cells to treat diseases. In particular, gene therapy for neurological diseases has recently achieved significant progress, with numerous studies investigating the use of adeno-associated viruses for the targeted delivery of therapeutic genetic fragments. This approach has potential applications for treating incurable diseases, including paralysis and motor impairment caused by spinal cord injury and Parkinson’s disease, and it is characterized by

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37

Lin, Gwo-Long, and Peng-Hsin Chen. "Dissemination of Biomedical Cell Sheets using Reality Technology and Digital Tools." Journal of Humanities and Social Sciences Studies 3, no. 4 (2021): 46–53. http://dx.doi.org/10.32996/jhsss.2021.3.4.5.

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Nowadays, with the advance of biomedical and pharmaceutical technology, new treatments such as cell therapy, cell sheets, etc. all provide patients other alternatives. However, the public has little knowledge in these new technologies and they also find them difficult to understand. Hence, this paper is aimed at providing the public with state-of-the-art technological knowledge and constructing an innovative field full of diversity, entertainment, and educational meaning with the assistance of Augmented Reality (AR) and Virtual Reality (VR). Taking the cell sheets technology, a kind of cell th

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38

Timmins, Lauren M., Alexandra M. Burr, Kristina Carroll, et al. "Selecting a Cell Engineering Methodology During Cell Therapy Product Development." Cell Transplantation 30 (January 1, 2021): 096368972110030. http://dx.doi.org/10.1177/09636897211003022.

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When considering the development pathway for a genetically modified cell therapy product, it is critically important that the product is engineered consistent with its intended human use. For scientists looking to develop and commercialize a new technology, the decision to select a genetic modification method depends on several practical considerations. Whichever path is chosen, the developer must understand the key risks and potential mitigations of the cell engineering approach. The developer should also understand the clinical implications: permanent/memory establishment versus transient ex

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39

Yung, Ma Chi. "Stem Cell Therapy in Heart Failure." Highlights in Science, Engineering and Technology 36 (March 21, 2023): 1222–29. http://dx.doi.org/10.54097/hset.v36i.6206.

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Heart related disease are among leading causes of death worldwide, but there are few efficient treatments available. Stem cells possess excellent potential because therapeutic methods now enhance patient quality of life and address comorbidities. A growing corpus of research demonstrates that local cardiac stem cells are activated to rejuvenate the heart. Recent clinical trials seem to confirm that stem cell therapy for people with persistent heart failure is safe. Along with the most effective pharmacological and technology therapies, stem cell therapy may improve NT-proBNP, exercise toleranc

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40

Hoh, Yin Kiong. "An Instant Update on Stem Cell Therapy." American Biology Teacher 87, no. 1 (2025): 6–12. https://doi.org/10.1525/abt.2025.87.1.6.

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Stem cell therapy, a cutting-edge technology, aims to replace damaged cells with healthy ones. Stem cells possess the remarkable ability to multiply and differentiate into various cell types, making them ideal candidates for regenerative medicine. This therapy holds promise for treating a wide range of conditions and injuries. In this review, I will delve into the historical context of stem cell research and therapy, provide updates on clinical trials for different conditions, address the challenges faced in stem cell therapy, and explore strategies to overcome these obstacles. Additionally, I

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41

Eshghifar, Nahal, Behnam Kamali Dehghan, Atieh Abedin Do, Saeideh Zamani Koukhaloo, Mohsen Habibi, and Farkhondeh Pouresmaeili. "Infertility cell therapy and epigenetic insights." Human Antibodies 29, no. 1 (2021): 17–26. http://dx.doi.org/10.3233/hab-200438.

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Recent advances in assisted reproductive technology (ART) have allowed couples with severe infertility to conceive, but the methods are not effective for all cases. Stem cells as undifferentiated cells which are found in different stages of embryonic, fetal and adult life are known to be capable of forming different cell types, tissues, and organs. Due to their unlimited resources and the incredible power of differentiation are considered as potential new therapeutic biological tools for treatment of infertility. For reproductive medicine, stem cells are stimulated in vitro to develop various

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42

Lawani, M. O., and K. E. Enerijiofi. "Gene Therapy for Sickle Cell Disease: Present Insights." GVU Journal of Science, Health and Technology 9, no. 1 (2024): 150–57. https://doi.org/10.5281/zenodo.13297352.

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ABSTRACTSickle Cell Disease (SCD) is an inherited red blood cell disorder resulting from a single-point mutation. It resultsin complications such as acute and chronic pain, infections, stroke, kidney disease, and heart failure that reducethe quality of life not only for affected persons but also for their families. It can be treated with drugs andbone marrow transplants, but there is no known cure for it. One of the potential cures is gene therapy, whichinvolves adding, editing or silencing and correcting genes by bioengineering techniques including CRISPR/Cas9system; zinc finger nucleases (ZN

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Farzamfar, Saeed, Niloofar Nazeri, Majid Salehi, et al. "Will Nanotechnology Bring New Hope for Stem Cell Therapy?" Cells Tissues Organs 206, no. 4-5 (2018): 229–41. http://dx.doi.org/10.1159/000500517.

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The potential of stem cell therapy has been shown in preclinical trials for the treatment of damage and replacement of organs and degenerative diseases. After many years of research, its clinical application is limited. Currently there is not a single stem cell therapy product or procedure. Nanotechnology is an emerging field in medicine and has huge potential due to its unique characteristics such as its size, surface effects, tunnel effects, and quantum size effect. The importance of application of nanotechnology in stem cell technology and cell-based therapies has been recognized. In partic

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44

Dytfeld, Dominik, Anna Łojko-Dankowska, Magdalena Matuszak, et al. "Road to clinical implementation of CAR-T technology in Poznań." Acta Haematologica Polonica 51, no. 1 (2020): 24–28. http://dx.doi.org/10.2478/ahp-2020-0006.

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AbstractThe objective of this paper is to present the process of the national and international accreditation leading to the establishment of the first certified chimeric antigen receptor T (CAR-T) Cell Unit in Poland on the basis of the Department of Hematology and Bone Marrow Transplantation in Poznan University of Medical Sciences and first successful CAR-T therapy in Poland. During 12 months from the initial decision to establish the CAR-T Cell Unit to the application of CAR-T cell treatment in the first patient, the center had to undergo the multidisciplinary external and internal trainin

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45

Zhao, Long, Quan Wang, Changjiang Yang, Yingjiang Ye, and Zhanlong Shen. "Application of Single-Cell Sequencing Technology in Research on Colorectal Cancer." Journal of Personalized Medicine 14, no. 1 (2024): 108. http://dx.doi.org/10.3390/jpm14010108.

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Colorectal cancer (CRC) is the third most prevalent and second most lethal cancer globally, with gene mutations and tumor metastasis contributing to its poor prognosis. Single-cell sequencing technology enables high-throughput analysis of the genome, transcriptome, and epigenetic landscapes at the single-cell level. It offers significant insights into analyzing the tumor immune microenvironment, detecting tumor heterogeneity, exploring metastasis mechanisms, and monitoring circulating tumor cells (CTCs). This article provides a brief overview of the technical procedure and data processing invo

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46

Li, Yuzhu. "CRISPR technology advances immunotherapy in cancer research: Research progress." Theoretical and Natural Science 82, no. 1 (2025): 70–75. https://doi.org/10.54254/2753-8818/2025.ka21016.

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CRISPR-Cas9 technology is profoundly revolutionizing adoptive cell immunotherapy in the field of cancer treatment, especially CAR-T and TCR-T cell therapy. The technology enables highly customized modification of T cells through precise gene editing, solving some of the challenges that exist in traditional therapies. This review mainly introduces the application progress of CRISPR-Cas9 in CAR-T and TCR-T therapy, as well as related technical principles, and provides reference for future adoptive cell immunotherapy for cancer and other related diseases. With more in-depth research and clinical

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47

Bryukhovetskiy, I. S., and A. S. Bryukhovetskiy. "SCIENTIFIC AND THEORETICAL VALIDATION OF DEVELOPMENT OF PERSONALIZED ANTI-CANCER CELL PREPARATION ONTHE BASES OF CLINICAL ONCOPROTEOMICS TECHNOLOGY." Journal of Clinical Practice 5, no. 1 (2014): 44–60. http://dx.doi.org/10.17816/clinpract5144-60.

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In the article the authors present analysis of current conventional methodological and technological approaches to contemporary therapy of cancer and certain malignant neoplasms. Based upon the revision of available concepts of clinical oncology, the scientific and theoretical validation of novel approaches to the development of innovative technologies of proteomebased regulatory tumor therapy was attempted. The authors defined their original viewpoint on the development of the preparations for personalized therapy of cancer and proposed a new methodology and alternative approach to the malign

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48

Park, Hyeseon, Yoo Kyung Kang, and Gayong Shim. "CRISPR/Cas9-Mediated Customizing Strategies for Adoptive T-Cell Therapy." Pharmaceutics 16, no. 3 (2024): 346. http://dx.doi.org/10.3390/pharmaceutics16030346.

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Clustered regularly interspaced short palindromic repeat-associated protein Cas9 (CRISPR/Cas9) technology is at the forefront of cancer immunotherapy innovation, offering precise and personalized treatment strategies. In this review, we discuss CRISPR/Cas9’s ability to precisely edit the genome, its impact on immune checkpoint control, and its application in immune cell engineering, where it surpasses traditional gene editing techniques. Originally inspired by bacterial defense mechanisms, this technology has made great strides in cancer immunotherapy as a mechanism to specifically target the

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Simonsson, Stina. "Stem cell therapy for osteoarthritis: Functional cartilage regeneration using 3d bioprinting technology." Open Access Government 44, no. 1 (2024): 228–29. http://dx.doi.org/10.56367/oag-044-11664.

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Stem cell therapy for osteoarthritis: Functional cartilage regeneration using 3d bioprinting technology Osteoarthritis presents a significant societal and economic burden. Stina Simonsson from the University of Gothenburg explains how EU-funded projects are using 3D bioprinting to create functional cartilage for OA treatment. Osteoarthritis (OA) is a widespread condition that affects millions of people globally. As the population ages and the obesity epidemic continues, the incidence of OA is expected to increase. 3D bioprinting and stem cell therapies are heralded as the future of medical tre

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Feyeux, M. "C-Stem, a new technology fro scale up of cell therapy production." Cytotherapy 22, no. 5 (2020): S43—S44. http://dx.doi.org/10.1016/j.jcyt.2020.03.043.

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