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Dissertations / Theses on the topic 'Teratogens'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Cantrell, Susannah M. "Embryotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)." free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9924870.

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2

Esch, Jennifer, and Guadalupe Sandoval. "Pharmacy Student Knowledge of Teratogens to Avoid in Pregnancy." The University of Arizona, 2010. http://hdl.handle.net/10150/623792.

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Class of 2010 Abstract<br>OBJECTIVES: The purpose of the study was to determine the knowledge of third year pharmacy students about the safety of certain medications during pregnancy and to assess their awareness of an important resource available on medication safety. METHODS: The study used an analytical cross-‐sectional design. A pre-‐test was administered to determine baseline knowledge. Dee Quinn provided a presentation on teratogens. The same test was then administered as a post-‐test to assess the amount of knowledge gained from the presentation. The pre and post-‐tests were matche

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3

Oliva, Jean L. (Jean Louise). "The Teratogenic Effects of Nocodazole and Acrylamide in Mus Musculus." Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc500254/.

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In two separate experiments, weight adjusted doses of nocodazole and acrylamide were injected intraperitoneally at various time intervals into twelve week old female mice. Within the nocodazole experiment, the doses were injected at varying time intervals before and after mating. On day seventeen of gestation, the female mice were sacrificed and their uterine contents examined. Nocodazole induced a significant increase in reproductive pathology per total implants when administered one hour after mating to the (SECxC57BL)F, stock: 5.00% total deads, 70.23% moles, and 3.41% abnormal fetuses. Ac

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4

Bates, Alan William. "Situs inversus and lateral asymmetry in larvae of the toad Xenopus laevis." Thesis, Queen Mary, University of London, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481544.

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5

Brown, Lisa. "Role of oxidative metabolism in the bioactivation of chemical teratogens : an in vitro study with rat embryo cells." Thesis, University of Surrey, 1986. http://epubs.surrey.ac.uk/848469/.

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The potential role of embryonic cells in the IN VITRO bioactivation of teratogens was investigated, with limb bud mesenchyme cells, (LB), and mid brain cells,(CNS), derived from 13 day old rat embryos. The cells were cultured for 5 days and during this period differentiated into foci of chondrocytes (LB) or neurones (CNS). The development of the cells in culture mirrored the IN VIVO development and therefore can be used as a teratogen screen. The presence of constitutive forms of cytochrome P450 isoenzyme forms b, c and d (Levin et. al. 1978 nomenclature) were detected in both cell types after

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6

Towers, Victoria, and Victoria Towers. "Zika Virus: Patient Education Recommendations." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625230.

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As the current growing threat to maternal-fetal health, the most recent and largest outbreak of the Zika virus has introduced the devastating fetal effects of microcephaly and other central nervous system deficits. Therefore, the need for appropriate recognition, treatment, management, and prevention of the Zika virus prompts the necessity for further education and high quality level research to be conducted and utilized. A search of the literature using the databases PubMed, UptoDate, and CINAHL was conducted for articles published between 2009 and 2016. In addition, key informant inter

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7

Zehir, Ahmet. "The relationship between the effects of teratogens in vivo and in vitro." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/11966.

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8

Hopkins, Keri Joel. "The effects of teratogens on serotonin expression in drosophila embryonic cell cultures." CSUSB ScholarWorks, 1993. https://scholarworks.lib.csusb.edu/etd-project/829.

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9

Ali, Nadeem. "Teratology in zebrafish embryos : a tool for risk assessment /." Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/10665293.pdf.

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10

Onat, Hatice Duygu. "Stimulation of gap junctional intercellular communication by the human teratogens retinoic acid and thalidomide." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961867310.

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11

Killeen, Alexis Ann. "A Caenorhabditis elegans Model to Detect Developmental Teratogens with Adverse Reproductive and Metabolic Effects." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6276.

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Obesity is a current epidemic in the United States. Greater than one third of adults and nearly one fifth of children are classified as obese (Ogden, 2014). Increased awareness of this problem has triggered interest into the potentially causal agents in our environment. These agents, termed obesogens, are a type of teratogen hypothesized to work during embryonic development by programming offspring to store excess fat. A type of teratogen, obesogens are also typically reprotoxic, affecting germline development and embryonic viability. These noxious teratogens span a variety of different chemic

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12

Hosako, Hiromi. "The role of p53 in normal development and teratogen-induced apoptosis and birth defects in mouse embryos." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3251.

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13

Charlton, Rachel. "The general practice research database as an alternative to registries for studying drug safety in pregnancy : anticonvulsants as a case study." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557803.

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Background: In recent years, there has been an increase in the use of automated healthcare databases for drug safety in pregnancy evaluation; their suitability for this purpose needs to be evaluated. Aim: To evaluate the utility of the United Kingdom’s General Practice Research Database (GPRD) to act as an alternative to pregnancy registries, using anticonvulsants as a case study. Methods: Pregnancies in women with epilepsy were identified and first trimester anticonvulsant exposure was determined. Major congenital malformations in the offspring were identified and verified. The risk of major

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14

Teär, Fahnehjelm Kristina. "Posterior ocular malformations in children : teratological aspects /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-470-4.

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15

Koundakjian, Edmund James. "The effects of 60-Hz electromagnetic fields and teratogens on Drosophila melanogaster embryonic cultures: Analysis of heat shock proteins 23 and 70." CSUSB ScholarWorks, 1997. https://scholarworks.lib.csusb.edu/etd-project/1493.

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16

Pillans, Peter Ian. "A study of acetylcholinesterase and cholinesterase in the fetal mouse brain and a study of the effects of three teratogens, vitamin A, cyclophosphamide and sodium valproate on the fetal mouse central nervous system." Doctoral thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/27212.

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There were two aims in this thesis. Firstly, to investigate cholinesterase and its isoenzymes in the fetal mouse brain, and secondly to study drug-induced fetal damage with the following objectives in mind: (i) to examine new markers for the evaluation and prediction of the teratogenic potential of drugs, and (ii) to try and throw more light on pathogenic mechanisms of drug injury with particular reference to the developing fetal central nervous system. Acetylcholinesterase activity in brain homogenates was determined colorimetrically and the isoenzymes were separated by polyacrylamide gel ele

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17

Thomas, Amy. "Paediatric non-alcoholic fatty pancreas disease and aortic intimal medial thickness: A study identifying potential fatty infiltration of the pancreas and its association with aortic IMT in children exposed to teratogens during pregnancy." University of the Western Cape, 2020. http://hdl.handle.net/11394/8151.

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Magister Scientiae (Medical Bioscience) - MSc(MBS)<br>The incidence of non-communicable diseases is increasing worldwide, with South Africa being no exception. Non-communicable diseases are classified as non-infectious and are often referred to as lifestyle diseases as they are caused by common, modifiable risk factors such as unhealthy diet, obesity, tobacco use and lack of physical activity. Due to the increasing prevalence of childhood obesity diseases such as fatty pancreas and fatty liver are becoming more common. Cardiovascular disease, and more specifically atherosclerosis is the underl

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18

Jergil, Måns. "Pluripotent Stem Cells of Embryonic Origin Applications in Developmental Toxicology /." Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109946.

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19

Carvalho, Marcelo Pires Nogueira de. "Patologia comparada das malformações congênitas em Bothrops jararaca e Crotalus durissus provenientes do sudeste brasileiro." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-13112014-152404/.

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Malformações congênitas, teratogenias ou anomalias do desenvolvimento são processos patológicos definidos como defeitos estruturais que se originam durante a vida embrionária. A ocorrência de teratogenias tem sido relatada em todas as classes de vertebrados e geralmente são incompatíveis com um período de vida prolongado. Uma ampla variedade destas malformações é descrita em répteis, principalmente nas espécies que compreendem a ordem Squamata. Acredita-se que as malformações nestes animais ocorram devido a causas genéticas e/ou ambientais incluindo-se, dentre outras possibilidades, a baixa va

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20

Morgan, M. K., Phillip R. Scheuerman, C. S. Bishop, and Rebecca A. Pyles. "Teratogenic Potential of Atrazine and 2,4-D Using Fetax." Digital Commons @ East Tennessee State University, 1996. https://dc.etsu.edu/etsu-works/2871.

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The teratogenic potential of commercial formulations of atrazine (40.8%) and 2,4-D was evaluated using FETAX (frog embryo teratogenic assay--Xenopus). Because these herbicides have been detected in ground and surface water, this study was designed to determine the adverse effects in buffer and natural water for both herbicides. All treatments showed a significant concentration-response effect on exposed embryos, except for the 2,4-D natural water sample. Atrazine (solubility of the commercial formula used 70 mg/L at 20 degrees C), compared to 2,4-D (solubility = 311 mg/L at pH = 1 and 25 degre

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21

Danielsson, Christian. "Role of the hERG-channel in arrhythmia and teratogenicity studies in animal models and the human embryonic heart /." Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-831-0/.

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22

Reis, Silênio Souza. "Avaliação do desenvolvimento de embriões e larvas de zebrafish (Danio rerio) expostos ao laser de baixa potência." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8986.

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Submitted by Onia Arantes Albuquerque (onia.ufg@gmail.com) on 2018-10-19T15:16:25Z No. of bitstreams: 2 Dissertação - Silênio Souza Reis - 2018.pdf: 3761275 bytes, checksum: a116ca60c456d780cfa9ea5e3dc8363c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-10-22T11:16:35Z (GMT) No. of bitstreams: 2 Dissertação - Silênio Souza Reis - 2018.pdf: 3761275 bytes, checksum: a116ca60c456d780cfa9ea5e3dc8363c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made a

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23

Galdones, Eugene. "The role of retinoic acid receptor gamma in retinoid-induced limb dysmorphogenesis /." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115711.

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Retinol (vitamin A) and its active metabolite, all-trans retinoic acid, signal through nuclear retinoic acid and retinoid X receptor (RAR/RXR) heterodimers. These complexes regulate the expression of genes involved in developmental processes such as limb development. In excess, retinoids are potent teratogens and cause marked reductive effects on the developing limb. The goal of this thesis was to elucidate the molecular mechanisms underlying retinoid-induced limb dysmorphogenesis. Specifically, using an in vitro limb culture system, I examined the involvement of one RAR isoform, RARgamma, in

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24

Ejdesjö, Andreas. "Teratogenic Predisposition in Diabetic Rat Pregnancy." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-178175.

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Pre-gestational diabetes increases the risk of congenital malformation in the offspring and both morbidity and mortality in the diabetic mother and her offspring. During pregnancy, high glucose levels act as a teratogen through several cellular and biochemical pathways and increased production of reactive oxygen species (ROS) has a central role in diabetic embryopathy. The aim of this work was to investigate the importance of genetic predisposition for congenital malformations and to study the genes involved in the teratogenic process of diabetic pregnancy. The crossbreeding of two rat strains

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25

Mallela, Murali Krishna. "Dysregulated Apoptosis in Teratogen-Induced Neural Tube Defects in Mice." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/37337.

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Dysregulation of apoptosis during development is a possible mechanism for teratogen-induced birth defects. Neural tube defects (NTDs) are the second most common fetal malformations. Non-specific stimulation of maternal immune system prevents birth defects. This study investigated the role of dysregulated apoptosis in formation of NTDs from two teratogens: valproic acid (VA) and an unknown teratogen found in tap water. Interferon- Î³ (IFN Î³) was used to stimulate maternal immunity to evaluate the role of altered apoptosis in this protective mechanism. Apoptosis was evaluated using flow cytom

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26

Clarke, David Oakley. "Embryonic lipid metabolism and the actions of the teratogen valproic acid." Thesis, University of Surrey, 1988. http://epubs.surrey.ac.uk/847310/.

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Lipid metabolism and the actions of valproic acid, a human teratogen, have been studied in the organogenesis-stage rat conceptus, using whole embryo culture techniques. All major lipid classes, particularly phospholipids, cholesterol and triacylglycerols, were synthesized de novo from acetate by the conceptus. Oleic acid and glucose were also incorporated into complex lipids. The pattern of lipid biosynthesis was dependent on the developmental stage of the conceptus. Despite this lipid biosynthetic activity, cholesterol uptake experiments suggested that the rat conceptus derives most of its re

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27

Imhof, Christiane. "Antibiotika-Therapie in der Schwangerschaft: teratogene Risiken von Makroliden, Doxycyclin und Cotrimoxazol." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-56960.

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28

Barnhisel, Taylor. "Carbaryl Exposure to Danio rerio Leads to Activation of the Aryl Hydrocarbon Receptor Pathway." Wittenberg University Honors Theses / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wuhonors1617979942441695.

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29

Gomes, Caroline. "Modelo de malária experimental na gestação como ferramenta para avaliação de embriotoxidade do artesunato." reponame:Repositório Institucional da UFPR, 2016. http://hdl.handle.net/1884/44488.

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Orientador : Dr. Paulo Roberto Dalsenter<br>Coorientadora : Drª Ana Cláudia Boareto<br>Tese (doutorado) - Universidade Federal do Paraná, Setor de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia. Defesa: Curitiba, 19/04/2016<br>Inclui referências : f. 56-61;83-86;106-108;116-120<br>Área de concentração<br>Resumo: A malária é uma doença infecciosa responsável por milhares de mortes, principalmente em países tropicais. Crianças menores de cinco anos e gestantes são consideradas como grupos de alto risco, devido a maior susceptibilidade às formas severas desta infecção que podem se

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30

JOURDAIN, FLORENCE. "Etudes de teratogenese des benzodiazepines chez l'animal et risques au cours de la grossesse." Strasbourg 1, 1995. http://www.theses.fr/1995STR15003.

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31

Carlson, Renee E. "Review and analysis of teratogenic effects on childhood development." Menomonie, WI : University of Wisconsin--Stout, 2004. http://www.uwstout.edu/lib/thesis/2004/2004carlsonr.pdf.

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32

Wagner, Svenja. "Teratogenic and Embryotoxic Effects of Polycyclic Aromatic Compounds Report." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-50460.

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Polycyclic aromatic compounds are ubiquitously distributed pollutants in the aquatic and terrestrial environment containing harmful properties on creatures such as carcinogenicity, teratogenicity and toxicity, but are not so well analyzed yet. In the present study, the embryotoxic and teratogenic effects of selected hydroxylated and methylated PACs on the embryonal development of Danio rerio as an aquatic model organism were analyzed with the Fish Embryo Toxicity Test (FET) and the Tail Length Test (TLT) to obtain information on the toxic and teratogenic impact of the tested PACs on the enviro

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33

Meijer, Willemijn Marieke. "Drug safety in pregnancy studying and communicating teratogenic risks /." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/297900455.

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34

GRAILLET, CHRISTOPHE. "Utilisation de l'embryon d'oursin pour l'etude du mode d'action cellulaire de molecules teratogenes." Paris 7, 1995. http://www.theses.fr/1995PA077032.

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Dans le but de fournir une alternative a l'utilisation d'animaux de laboratoire dans les etudes d'embryotoxicite, de nombreux tests in vitro sont en voie de developpement. Ce travail presente l'utilisation de l'embryon d'oursin en tant que modele d'etude de l'embryotoxicite de differentes molecules teratogenes: cyclophosphamide, chlorambucil, allopurinol, acide 2,4,5-tirchlorophenoxyacetique et un retinoide de synthese. Nous avons pu montrer que ces molecules provoquaient l'apparition d'anomalies du developpement chez les embryons d'oursin. Dans la plupart des cas l'embryotoxicite est plus for

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35

Van, der Schoor Ciska. "An in vivo and in ovo evaluation of the toxicity of Sibutramine." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/46008.

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Sibutramine hydrochloride monohydrate is a weight loss agent banned from most global markets due to reports of serious adverse events including death. It is classified as a serotonin-norepinephrine reuptake inhibitor and acts within the central nervous system by inhibiting the reuptake of these neurotransmitters essentially influencing satiety and also energy expenditure. Despite its ban, sibutramine is still available for use in some countries and is often an unlisted ingredient in herbal or natural weight loss products. This leads to the oblivious and unintentional consumption of this compou

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36

Morgan, M., Phillip R. Scheuerman, C. Bishop, and Rebecca A. Pyles. "The Teratogenic Potential of Atrazine and 2,4-D Using FETAX." Digital Commons @ East Tennessee State University, 1994. https://dc.etsu.edu/etsu-works/2900.

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37

DIDES, PIERRE-YVES. "Toxicite de la vitamine a ou retinol." Nice, 1991. http://www.theses.fr/1991NICE6511.

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38

Amore, Benny Michael. "Mechanism of carbamazepine teratogenicity /." Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/7939.

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39

Hill, Denise Suzanne. "Investigations into arsenate-induced neural tube defects in a mouse model." [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-3274.

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40

Marques, Nelson Fernando Quallio. "Avaliação teratológica da exposição da Morinda citrifolia Linn em ratas Wistar." reponame:Repositório Institucional da UFPR, 2009. http://hdl.handle.net/1884/20683.

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41

High, Kim. "Dietary fat modulation of phenytoin teratogenicity in CD-1 mice." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56661.

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The hypothesis of this study was that dietary n-3 fatty acids protect against phenytoin (P) teratogenicity by inhibiting embryonic prostaglandin H synthase bioactivation of P and/or by delaying embryonic development. Female caesarian-derived (CD-1) mice were fed a safflower (SAFF)- or a cod liver/linseed oil (CLO/LO)-based diet for three weeks prior to impregnation and throughout pregnancy. The CLO/LO diet, compared to the SAFF diet, reduced malformations and fetal growth retardation due to P. Open eye defect was the only anomaly induced by P in CLO/LO fetuses while P produced cleft palates on

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42

Varriano, Ana Augusta. "O impacto da exposição perinatal ao litio sobre emocionalidade e depressão em ratos." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311366.

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Orientador : Nancy Airoldi Teixeira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-01T21:47:52Z (GMT). No. of bitstreams: 1 Varriano_AnaAugusta_M.pdf: 14887267 bytes, checksum: 41f3f8b0e4d2d1b63068e5abe1966e30 (MD5) Previous issue date: 2002<br>Resumo: Sais de lítio (Lt) são freqüentemente usados na psiquiatria no tratamento da mania e na prevenção das crises recorrentes do transtorno bipolar. Recentes dados indicam que a descontinuidade do tratamento com Lt resulta em alta taxa de relapso do transtorno bipo

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Guilherme, Marcia Cristina Guimarães. "Estudo do comportamento da prole de ratas tratadas com litio." [s.n.], 2002. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311365.

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Orientador : Nancy Airoldi Teixeira<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-03T11:00:04Z (GMT). No. of bitstreams: 1 Guilherme_MarciaCristinaGuimaraes_M.pdf: 18477083 bytes, checksum: 672dd9860329d557bc62d719463c779b (MD5) Previous issue date: 2002<br>Resumo: o lítio (Lj+)é comumente utilizado como agente estabilizador do humor no tratamento e profilaxia de pacientes com transtorno afetivo bipolar. Estudos recentes indicam que pacientes bipolares grávidas não devem ser orientadas a interromper o trata

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44

Rosa, Fraga Lucas. "Analysing phenotypes and molecular mechanisms of thalidomide and Primodos teratogenesis." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=231144.

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Thalidomide was discovered to be teratogenic over 50 years ago, but is far from being a historical problem. A new generation of thalidomide survivors have been reported in Brazil, where the drug is used to treat leprosy complications and multiple myeloma. The mechanisms underlying thalidomide teratogenesis are not fully understood. Cereblon (CRBN) protein has been identified as a target of thalidomide. Cereblon is part of an E3 ubiquitin ligase complex with Damaged DNA Binding protein 1 and Cullin-4A. I have analysed the expression patterns of CRBN and its binding partners in wildtype and thal

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45

COISSARD, ANNE-NADINE. "Benzodiazepines et grossesse : complications neonatales." Lyon 1, 1993. http://www.theses.fr/1993LYO1M193.

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46

Gnanabakthan, Naveen. "Understanding the basis of 5-Bromo-2'-deoxuridine teratogen specificity in organogenesis stage mouse embryos." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112624.

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5-Bromo-2'-deoxyuridine (BrdU), a thymidine analogue, is genotoxic and teratogenic. The exposure of mouse embryos to BrdU at doses that cause malformations induces oxidative stress and an embryonic stress response characterized by an increase in c-Fos dependent AP-1 DNA binding. The goal of this thesis was to test the hypothesis that development is disturbed at sites where BrdU is incorporated into DNA, triggering oxidative stress and c-Fos induction. Gestation day 9 CD-1 mice were treated with BrdU and embryos were obtained for immunolocalization of BrdU, 8-oxoguanine, a biomarker for oxidati

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47

Rogers, Ian. "Teratogenic and molecular methods for the study of mouse gastrulation and neurulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0004/NQ41299.pdf.

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48

Blain, Danielle. "Metallothionein pre-induction by zinc and isotretinoin teratogenicity in CD-1 mice." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23988.

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This investigation evaluated the potential protective role of Zn, through modulation of MT, against the teratogenic effects of isotretinoin (ITR), a dermatological drug which causes oxidative damage, in CD-1 mouse embryos. Significant induction of MT by Zn supplementation was observed in mouse embryos both in vivo and in vitro. On gestational day (GD) 6.5, pregnant mice received a subcutaneous Zn injection of 0 (saline), 20 and 40 mg/kg, resulting in embryonic MT concentrations of 12.5, 54.5 and 93.4 $ mu$g/g protein, respectively, after 48h. Embryos were extracted at GD 8.5 and incubated with

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Helena, de Castro Chagas Maria. "Níveis de retinol sérico após consumo de arroz enriquecido com vitamina A - UltraRice." Universidade Federal de Pernambuco, 2003. https://repositorio.ufpe.br/handle/123456789/9043.

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Made available in DSpace on 2014-06-12T23:04:16Z (GMT). No. of bitstreams: 2 arquivo8930_1.pdf: 299711 bytes, checksum: d9a7d8cb5456a5f22e43060a44c60c44 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2003<br>Apesar do tempo transcorrido desde o descobrimento e síntese da vitamina A a carência desta vitamina continua sendo um dos maiores problemas de saúde e nutrição, afetando quase um bilhão de pessoas no mundo, com conseqüências devastadoras dada a ubiqüidade do seu papel no metabolismo intermediário. A carência de vitamina A afeta d

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Gravemann, Ute. "Synthese achiraler, racemischer und enantiomerenreiner Valproinsäure-Analoga mit antikonvulsiver, neurotoxischer und teratogener Aktivität." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968536697.

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