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Dissertations / Theses on the topic 'Tetracyclines'

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1

Jones, Natalie Kaye. "Tetracyclines In Swine Waste." TopSCHOLAR®, 2014. http://digitalcommons.wku.edu/theses/1326.

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Antibiotics are added to animal feeds as prophylactic agents and to encourage weight gain in livestock. However, there is concern that the widespread use of antibiotics in animal agriculture encourages for the selection of resistance genes and has contributed to the rise of multiply antibiotic resistant strains of pathogenic bacteria. For this reason, there is interest in quantifying antibiotics in environmental samples. The determination of three antibiotics in swine waste, namely chlortetracycline, tetracycline and oxytetracycline, using LC-MS with electrospray ionization is presented here i
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2

Dunston, Christopher R. "The anti-inflammatory action of tetracyclines." Thesis, Aston University, 2008. http://publications.aston.ac.uk/15301/.

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For six decades tetracyclines have been successfully used for their broad spectrum antibiotic effects. However, non-antibiotic effects of tetracyclines have been reported. The anti-inflammatory effects of tetracycline drugs have been investigated in the context of a range of inflammatory diseases including sepsis and a number of neurodegenerative diseases. This thesis investigates the effects of a range of clinically important tetracyclines (oxytetracycline, doxycycline, minocycline and tigecycline) on the ability of the J774.2 cell line to produce nitric oxide when stimulated with the bacteri
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3

Sergeant, Claire. "Primary effects of the tetracyclines on Pseudomonas aeruginosa." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=56894.

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Pseudomonas aeruginosa grew in the presence of 10 $ mu$g/ml tetracycline (TC) or chlorotetracycline (CTC) in a minimal medium containing Mg$ sp{++}$. Growth is inhibited, with a six-fold increase in length of the lag phase. Cells revert to sensitivity when returned to antibiotic-free medium. Substitution of Mg$ sp{++}$ in the growth medium of CTC-resistant strains with Ca$ sp{++}$ and Sr$ sp{++}$ resulted in dramatic changes in growth and cell mass of cultures. Exposure of CTC-grown cells to EDTA did not result in cell lysis. SDS-PAGE of outer membrane proteins of resistant cells revealed loss
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4

Wright, Peter Maughan. "Multiplicative Expansion of the Pool of Fully Synthetic Tetracycline Antibiotics." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10504.

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This thesis describes the development of chemical pathways for the preparation of more than 80 novel fully synthetic tetracyclines with structural variability at positions C5 and C5a. Progress toward the synthesis of 5-hetero-tetracyclines, another new class of tetracycline antibiotics, is also described. The results detailed herein – including successful C-ring-forming Michael–Claisen cyclizations of numerous modified AB precursors with just a few of the extraordinarily diverse D-ring precursors known to be effective nucleophiles in this key coupling reaction – represent the first steps towar
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5

Humbert, Philippe. "Contribution a l'etude pharmacologique des tetracyclines et du 5-methoxypsoralene." Besançon, 1993. http://www.theses.fr/1993BESA3701.

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6

Sauers, Daniel J. "Light directed gene patterning using photocaged doxycycline /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 196 p, 2010. http://proquest.umi.com/pqdweb?did=1993328811&sid=6&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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7

Griffin, Michael O. "Mechanisms underlying the cardioprotective effects of tetracyclines in myocardial ischemic injury." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3283466.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed June 2, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 145-165).
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8

Rocha, Rafael dos Santos. "Polyphasic characterization of heterotrophic bacteria from shrimp farm environments to tetracyclines." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=16669.

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CoordenaÃÃo de AperfeÃoamento de Pessoal de NÃvel Superior<br>Antimicrobial agents of tetracycline class has been extensively used in aquaculture for disease control and growth promotion. Thus, the aim of this study was to evaluate the polyphase profile of the bacterial community in shrimp farming environment front antimicrobial classes of tetracyclines, focusing on Vibrio genus. Water and sediment samples were collected four (4) shrimp farms: two (2) in the state of Cearà and two (2) in the state of Rio Grande do Norte, of points: estuary, supply channel, pond and drainage channel. Cultivable
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9

Leng, Zhongtai. "Distribution and mobility of antibiotic resistant genes in oral/urogentital [sic] bacteria." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/9273.

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10

TEIXEIRA, LUCIANE dos S. "Estudos das propriedades opticas dos complexos europio tetraciclinas e suas aplicacoes na deteccao de lipoproteinas." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9561.

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11

GRASSO, ANDREA N. "Estudos espectroscopicos dos complexos europio-tetraciclinas e suas aplicacoes na deteccao de peroxido de hidrogenio e peroxido de ureia." reponame:Repositório Institucional do IPEN, 2010. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9567.

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12

Lion-Daolio, Sylvie. "Analgesie peridurale thoracique pour symphyse pleurale aux tetracyclines : a propos de 13 observations." Amiens, 1990. http://www.theses.fr/1990AMIEM064.

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13

Shai, Leshweni Jeremia. "Induction of apoptosis by lithium and minocycline in mammalian cells : role of growth-related genes, protein kinase c and calcium." Thesis, University of Limpopo, 1998. http://hdl.handle.net/10386/2140.

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14

Georges, Agnès. "Chlamydia Trachomatis et tetracyclines : étude de souches récidivantes par PCR-RFLP du gène omp1." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2P094.

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15

Chen, Wan-Ru. "Interactions of tetracycline antibiotics with dissolved metal ions and metal oxides." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24698.

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Thesis (Ph.D.)--Civil and Environmental Engineering, Georgia Institute of Technology, 2008.<br>Committee Chair: Huang, Ching-Hua; Committee Member: Kim, Jaehong; Committee Member: Pavlostathis, Spyros; Committee Member: Stack, Andrew; Committee Member: Yiacoumi, Sotira
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16

Chukwudi, Chinwe Uzoma. "dsRNA as a target for tetracyclines and berberine, and a stress response regulator in Escherichia coli." Thesis, Royal Veterinary College (University of London), 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.572453.

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17

Abdulrheem, Ali Jamal. "Detection and Quantitation of Tetracycline Antibiotics in Agricultural Swine Wastes." TopSCHOLAR®, 2017. http://digitalcommons.wku.edu/theses/1931.

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The spread of tetracyclines through agricultural systems is causing the present bacteria to develop antibiotic resistance. The spread of this bacteria, as well as the tetracycline antibiotics in the environment is dangerous because these antibiotics pose health hazards for humans. The overuse of antibiotics, which are added to livestock feed, results in the antibiotics being released into the environment via animal feces. In this research, we have attempted to design an analytical method to isolate antibiotics from agricultural wastes with subsequent detection using liquid chromatography and m
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18

Teixeira, Luciane dos Santos. "Estudos das propriedades ópticas dos complexos európio tetraciclinas e suas aplicações na detecção de lipoproteínas." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/85/85134/tde-12082011-133857/.

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Este trabalho apresenta as propriedades ópticas dos complexos Európio Tetraciclinas (EuTcs) na presença de LDL e de LDL oxidada com potenciais aplicações em análises clínicas. Foram escolhidos quatro elementos da família das Tetraciclinas: Tetraciclina (Tc), Clorotetraciclina (CTc), Metatetraciclina (MTc) e Oxitetraciclina (OTc) para fazerem parte dos complexos com o íon európio. As melhores condições para se formar os complexos eficientemente foram determinadas, através das medidas dos parâmetros ópticos como: absorção, emissão e de tempo de vida. As melhores concentrações de európio nos com
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19

Hellström, Maj-Karin. "On antimicrobial approaches to arrest and control chronic periodontitis /." Göteborg : Department of Periodontology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, 2009. http://hdl.handle.net/2077/19380.

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20

Garcia-Torres, Jason. "Development of a dual Fries-Claisen rearrangement strategy." Thesis, Loughborough University, 2012. https://dspace.lboro.ac.uk/2134/11002.

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Synthetic approaches towards linear fused carbon rings have been developed over the last decades due to their high interest as compounds with potential antibiotic activity and as organic electronics. The application of a novel iterative route towards linear fused carbon ring systems could provide a versatile new mode of access to complex substituted ring systems. Studies have previously demonstrated the use of an allylation-double Claisen-RCM sequence to build fused carbon rings (C). In this thesis we described our work to expand the use of this methodology by developing milder reaction condit
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21

Pérez, Rodríguez Michael. "Desenvolvimento de métodos quantitativos e sistema de screening para a determinação de tetraciclinas em medicamentos veterinários e alimentos de origem animal usando procedimentos de análise por injeção em fluxo /." Araraquara, 2016. http://hdl.handle.net/11449/143932.

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Orientador: Leonardo Pezza<br>Banca: Fabíola Manhas Verbi Pereira<br>Banca: Edilene Cristina Ferreira<br>Banca: Aline Theodoro Toci<br>Banca: Danilo Luiz Flumignan<br>Resumo: Este trabalho descreve o desenvolvimento de métodos analíticos ambientalmente mais amigáveis utilizando sistemas de screening e procedimentos de análise por injeção em fluxo para a detecção e quantificação de antibióticos, da classe das tetraciclinas, em amostras de medicamentos veterinários e alimentos de origem animal como leite bovino e suplementos de ovos. Os métodos desenvolvidos foram baseados na reação de acoplamen
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22

Hambálková, Kateřina. "Odstraňování mikropolutantů při úpravě pitné vody." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216363.

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Intrusion of pharmaceuticals into surface and drinking water is nowadays a problem, that is solved all over the world. This diploma thesis is focused on the removal of pharmaceuticals from water by coagulation. The efficiency of two coagulant agents - chitosan and ferric sulphate was compared. For comparison was used adsorption on a granular-activated-carbon. Efficiency of removal was investigated by UV-VIS spectrophotometer and HPLC.
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23

Holtsche, Maike Marleen [Verfasser]. "Assoziation von Serumautoantikörpern mit der Klinik und dem Outcome der BLISTER (Bullous Pemphigoid Steroids and Tetracyclines) Studie / Maike Marleen Holtsche." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2018. http://d-nb.info/116699886X/34.

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24

Reynes, Jean-Paul. "Contribution a l'amelioration genetique de la production de tetracyclines et a l'excretion de proteines chez streptomyces aureofaciens et streptomyces rimosus." Toulouse 3, 1987. http://www.theses.fr/1987TOU30242.

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25

Sussman, Robin Judith. "I. Synthesis of C4-Modified Tetracyclines II. Aldolizations of Pseudoephenamine Glycinamide and Applications Toward the Synthesis of Monocyclic β-Lactam Antibiotics". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467383.

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Part one of this thesis describes the production of C4-modified tetracycline derivatives. Our synthetic strategy originally targeted SF2575, a C4-oxygenated tetracycline analog with antiproliferative properties, but was later amended to target antibacterial C4-oxygentaed minocycline analogs. The C4-modified tetracyclines were accessed utilizing a strategy based on the Myers’ platform to 6-deoxytetracyclines (Michael–Claisen cyclization between AB enone 71 and D-ring phenyl esters 44 or 84) in addition to the 4th generation route to tetracycline key AB enone (Michael–Claisen cyclization between
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26

Calixto, Carolina Maria Fioramonti. "Utilização de eletrodos compósitos na análise voltamétrica de tetraciclinas em amostras biológicas e ambientais." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/75/75135/tde-23042013-104752/.

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Neste trabalho, um eletrodo compósito à base de grafite e poliuretana (EGPU) 60% (grafite, m/m) foi avaliado quanto ao seu potencial para determinação dos antibióticos da família das tetraciclinas em amostras de água natural, de urina bovina e humana, e em amostras de leite bovino e humano. Visando desenvolver métodos simples, de baixo custo e com baixa geração de resíduos, o eletrodo foi usado sem modificação, para atender a estes propósitos e considerando os níveis de concentração das tetraciclinas nas amostras biológicas. A otimização dos parâmetros em voltametria de pulso diferencial (DPV)
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27

Hroncová, Michala. "Studium dostupnosti antibiotik v půdě." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2020. http://www.nusl.cz/ntk/nusl-432994.

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The diploma thesis is focused on the determination of tetracyclines, sulfonamides and fluoroquinolones from soil. Antibiotics such as tetracycline, chlortetracycline, oxytetracycline. ciprofloxacin, trimethoprim, sulfamethaxazole and sulfadiazin were selected due to frequent use in veterinary medicine. Due to the fact that the soil is a complex matrix and contains many components that can interfere with the detection signal of analytes, it was necessary to use the MAX column in the SPE method, which removes fulvic aned humic acid from analytes and the HLB column Final analysis of the analytes
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28

Mpofu, Tariro Ann-Maureen. "Comparison of the neuroprotective potential of theanine and minocycline." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1003253.

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Stroke is one of the most common causes of disability and death worldwide. The most commonly experienced stroke in the clinical setting is focal ischaemia in which the middle cerebral artery (MCA) is occluded and leads to a complex series of various pathophysiological pathways that ultimately lead to neuronal cell death. Several studies have been conducted on various therapeutic agents in the search for a neuroprotective drug and various animal models have been used to carry out this research. While theanine, a component of green tea and minocycline, a tetracycline antibiotic, have been shown
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Lisá, Hana. "Problematika stanovení reziduí léčiv v odpadních vodách." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2011. http://www.nusl.cz/ntk/nusl-233324.

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The PhD thesis deals with determination of sulfonamides and tetracyclines in waste waters. Sulphonamides and tetracyclines are widely used in human and veterinary medicine. They are biologically active compounds and block biological processes in waste water treatment plants. These substances can influence microorganisms in the environment. Sulphonamides and tetracyclines induce resistance in low concentrations. These substances penetrate into the environment from industrial production, use in households, hospitals, veterinary clinics and fish farms. Tetracyclines and sulphonamides were determi
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30

Lambs, Luc. "Etudes sur la speciation des tetracyclines dans le plasma sanguin et determination des structures de leurs complexes metalliques predominants : influence sur la biodisponibilite de ces drogues." Toulouse 3, 1988. http://www.theses.fr/1988TOU30149.

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31

THEODORO, LETICIA H. "Estudo comparativo, atraves de microscopia eletronica de varredura, da acao de diferentes substancias quimicas e do laser de Er:YAG, na remocao de smear layer, em superficies radiculares submetidas a raspagem e aplainamento." reponame:Repositório Institucional do IPEN, 2001. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10867.

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32

Viera, Patricia Veronica Aulestia. "Nanofibras poliméricas carregadas com oxitetraciclina para tratamento de alveolite seca: estudo em ratos." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/23/23147/tde-25062018-111656/.

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A alveolite seca é uma das complicações pós-operatórias mais comuns e sintomáticas na exodontia, porém, até o momento não possui um protocolo de tratamento definido. A oxitetraciclina (OTC) é um antibiótico de amplo espectro utilizado no tratamento de múltiplas infecções. Entretanto, nos últimos anos as tetraciclinas de primeira geração, tais como a OTC, têm sido evitadas devido ao surgimento de microrganismos resistentes. Afortunadamente, nos últimos anos tem se observado uma tendência contrária graças às medidas de controle no uso de antibióticos. Sistemas de liberação controlada podem evita
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33

Sachikonye, Tinotenda Chipo Victoria. "Development and assessment of minocycline sustained release capsule formulations." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1013127.

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The use of minocycline for the treatment of a broad range of systemic infections and for severe acne has been associated with vestibular side effects. The severity of side effects may lead to poor adherence to therapy by patients. The use of sustained release formulations of minocycline that display slow dissolution of minocycline following administration may be beneficial in reducing the incidence and severity of side effects. Therefore, sustained release capsule dosage forms containing 100 mg minocycline (base) were manufactured and assessed for use as sustained release oral dosage forms of
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34

Bordon, Vanessa Fernandes. "Pesquisa de genes de resistência a antimicrobianos em filés de tilápia comercializados no município de São Paulo-SP." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/6/6135/tde-15092014-131053/.

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IIntrodução A utilização excessiva de antimicrobianos na medicina humana, veterinária e agricultura resultou no aparecimento da resistência bacteriana. Este fenômeno gera problemas de saúde pública que podem resultar na reemergência de doenças infecciosas. O uso de antibióticos, principalmente de forma profilática, tornou-se prática na aquicultura, como ocorre no Brasil, onde a regulamentação para o uso de medicamentos veterinários é ineficiente. Além disso, há evidências da transferência de organismos resistentes para humanos por meio do consumo de produtos de origem animal, quando, durante
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35

Barbeyrac, Bertille de. "Application des techniques d'hybridation au diagnostic des infections à mycoplasmes et chlamydia trachomatis et à la détection du gène de résistance aux tetracyclines TET(M) chez certaines bactéries responsables d'infections génitales." Bordeaux 2, 1994. http://www.theses.fr/1994BOR28307.

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36

Khalil, Dima. "Résistance aux antibiotiques chez Mycoplasma bovis : mécanismes moléculaires et évolution en France." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1238/document.

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Mycoplasma (M.) bovis est une bactérie pathogène des bovins, à l'origine de signes cliniques divers, comme des mammites, des arthrites, des otites et des bronchopneumonies, ces dernières étant majoritaires en France. Les mycoplasmoses à M. bovis ont un fort coût économique et leur contrôle impose une importante mobilisation sanitaire et un recours très fréquent à l'antibiothérapie. Peu de données étaient disponibles jusque récemment concernant le typage moléculaire et l'antibiosensibilité des souches françaises de M. bovis. Deux études antérieures à ce travail et réalisées au sein de l'UMR « M
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Volkers, Gesa [Verfasser]. "Röntgenkristallographische Untersuchungen zum enzymatischen Abbau von Tetracyclinen durch die Monooxygenase TetX sowie zur Erkennung natürlicher Tetracyclin-Abbauprodukte durch den Tet-Repressor / Gesa Volkers." Greifswald : Universitätsbibliothek Greifswald, 2011. http://d-nb.info/1016938314/34.

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Balsalobre, Livia Carminato. "Resistência a tetraciclinas em isolados clínicos e ambientais de Escherichia coli, Klebsiella pneumoniae e Aeromonas spp.: identificação e mapeamento do ambiente genético de genes tet." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/6/6135/tde-11102014-091855/.

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Introdução. A resistência bacteriana a antibióticos é aceita como um dos maiores problemas de saúde pública. As tetraciclinas são antibióticos de amplo espectro, e após seu uso indiscriminado observou-se o surgimento de bactérias resistentes, levando médicos e veterinários a diminuírem seu uso. Objetivos. Verificar o perfil de sensibilidade a tetraciclinas em isolados clínicos e ambientais de Escherichia coli, Klebsiella pneumoniae e Aeromonas spp., bem como pesquisar os principais genes tet associados à resistência a esta classe de antibióticos e determinar a potencial forma de disseminação d
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Gaillard, Tiphaine. "Identification et validation de marqueurs moléculaires de la résistance de Plasmodium falciparum à la doxycycline." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5036/document.

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La doxycycline est l’une des molécules recommandées par l’OMS en prophylaxie pour les voyageurs dans les zones d’endémie palustre, en particulier dans les zones de multirésistance. Une étude récente avait suggéré que les isolats de P. falciparum présentaient différents niveaux de sensibilité à la doxycycline et que l’augmentation du nombre de copies de deux gènes, pfmdt ou pftetQ, pouvait être associée à une baisse de sensibilité.Le premier objectif de ce travail a consisté à valider ce modèle à partir d’un nouvel échantillonnage d’isolats africains. Le second objectif était d’évaluer le nombr
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Ezzariai, Amine. "Devenir des antibiotiques lors du traitement aérobie et anaérobie des boues de STEPs pour une valorisation agronomique." Thesis, Toulouse, INPT, 2018. http://www.theses.fr/2018INPT0071/document.

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L’utilisation massive des antibiotiques contribue à leur accumulation dans les boues des stations d’épurations. L’application directe des boues est parmi les sources de dissémination des antibiotiques et des gènes de résistance aux antibiotiques. Le compostage et la méthanisation sont parmi les bioprocédés de traitement des boues qui permettent d’éliminer ou réduire les teneurs de certains antibiotiques. Dans ce travail, une boue primaire de la STEP de Marrakech a été contaminée par trois familles d’antibiotiques (macrolides, tétracyclines, fluoroquinolones) pour conduire 4 essais de compostag
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SICCHIERI, LETICIA B. "Estudo e caracterização de marcadores ópticos para a aterosclerose." reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26949.

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Submitted by Marco Antonio Oliveira da Silva (maosilva@ipen.br) on 2016-12-22T16:50:04Z No. of bitstreams: 0<br>Made available in DSpace on 2016-12-22T16:50:04Z (GMT). No. of bitstreams: 0<br>O presente trabalho buscou investigar a formação da placa de aterosclerose através de caracterização da autofluorescência do tecido e do plasma na presença de marcadores fluorescentes. Para realizar o estudo, coelhos foram divididos em dois grupos: um grupo controle onde os animais foram submetidos a uma dieta normal e um grupo experimental onde os animais foram submetidos a uma dieta hipercolesterolêmic
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42

Phisit, Prapunwattana Yongyuth Yuthavong. "Mechanism of antimalarial action of tetracycline /." abstract, 1986. http://mulinet3.li.mahidol.ac.th/thesis/2529/29E-Phisit-P.pdf.

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43

Pasternak, Björn. "Towards surgical use of matrix metalloproteinase biology." Doctoral thesis, Linköpings universitet, Ortopedi och idrottsmedicin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11489.

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Matrix metalloproteinases (MMPs), such as collagenases, are a family of enzymes capable of degrading most constituents of the extracellular matrix. MMPs are thought to be involved in the aetiopathogenesis of tendon rupture. Additionally, failure of healing has in some instances been associated with elevated levels of MMPs. We have studied (a) the effects of the MMP-inhibitor doxycycline on healing of tendons and intestines in experimental models and (b) systemic levels of MMPs and their endogenous inhibitors (TIMPs) in patients with tendon rupture. In the first study, systemic doxycycline trea
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44

Woodward, Rebecca Stanton Wain. "Analysis of tetracycline resistance in compost bacilli." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259753.

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45

BEKAERT, ALAIN. "La bikaverine, tetracycline heterocyclique a activite carcinostatique." Paris 11, 1991. http://www.theses.fr/1991PA112393.

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Synthese de la bikaverine, 6,11-dihydroxy 3,8-dimethoxy 1-methyl benzo(b) xanthene 7,10,12-trione. La bikaverine est un pigment a squelette benzoxanthone derive de la naphtazarine a proprietes antiprotozoaire et antimitotique, isole de divers fusarium. Cette these illustre une nouvelle methode de synthese basee sur la condensation thermique des bases de mannich. Ce travail debute par la synthese de naphtazarines diversement substituees par des groupes hydroxyles, halogenes, ou methoxyles. Une etude de la structure des naphtazarines substituees en-2 a ete effectuee. Le second chapitre est consa
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46

Duarte, Elisabeth Carmen. "Randomized controlled trial of artesunate plus tetracycline versus standard treatment (quinine plus tetracycline) for uncomplicated plasmodium falciparum malaria in Brazil." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55491.

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A triple blind randomized controlled trial was undertaken in a Brazilian Amazon region (Cuiaba-MT), to compare the effectiveness and side effects of oral artesunate (7 days, total dose = 0.75 g) plus tetracycline (7 days, total dose = 10.5 g) (AT) and oral quinine (3 days, total dose = 6 g) plus tetracycline (7 days, total dose = 10.5 g) (QT). Eligible patients had uncomplicated P. falciparum malaria; age $ geq$ 14 years; no previous malaria treatment related to the present attack; and, if women, indication of absence of pregnancy. Clinical exam and blood tests were performed at baseline (day
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Dodgen, Taylor L. "Escherichia coli and Antibiotic Resistance to Tetracycline Antibiotics." Lynchburg, Va. : Liberty University, 2008. http://digitalcommons.liberty.edu.

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48

Warburton, Philip James. "The molecular epidemiology of tetracycline resistance in periodontitis." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431225.

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Chung, Whasun Oh. "Macrolide resistance and its linkage to tetracycline resistance /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/9279.

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Yasin, Ahmed. "Analytical studies of the tetracycline group of antibiotics." Thesis, University of Bath, 1986. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374840.

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