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Journal articles on the topic 'Tetracyclines'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Fuoco, Domenico. "Cytotoxicity Induced by Tetracyclines via Protein Photooxidation." Advances in Toxicology 2015 (March 24, 2015): 1–10. http://dx.doi.org/10.1155/2015/787129.

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Background. Bacterial ribosomes have been considered the principal targets of tetracyclines. Recently, new clinical data has shown how other biomacromolecules are involved in the cellular damage of bacteria. Researchers are now reconsidering the pharmacological classification of tetracyclines, not only based on their semisynthetic or synthetic generations but also following the new mechanisms of action that are progressively being discovered. Materials and Methods. The toxicity properties of seven tetracycline derivatives (tetracycline, oxytetracycline, demeclocycline, chlortetracycline, doxyc

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2

Velhner, Maja, and Dubravka Milanov. "RESISTANCE TO TETRACYCLINE IN ESCHERICHIA COLI AND STAPHYLOCOCCUS AUREUS: BRIEF OVERVIEW ON MECHANISMS OF RESISTANCE AND EPIDEMIOLOGY." Archives of Veterinary Medicine 8, no. 1 (2016): 27–36. http://dx.doi.org/10.46784/e-avm.v8i1.103.

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In this work we briefl y present the mechanisms of resistance to tetracyclines. Tetracycline’s were introduced in clinical practice in 1948, and are used for the therapy in human and veterinary medicine or as growth promoters in livestock industry. Th ere are three major mechanisms of resistance to tetracyclines. Gram negative bacteria utilize effl ux pump system of proteinaceous transporters in eliminating the drug from the cell. This mechanism of resistance is encoded by tet genes that belong to the group 1. Gram positive bacteria promote resistance to tetracyclines by producing soluble cyto

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3

Sangeetha, A1 Anil Kumar B2 Satish Kumar K3and Ambica G4. "The pharmacological perspectives of Tetracyclines in Veterinary Medicine." Science World a monthly e magazine 3, no. 5 (2023): 618–25. https://doi.org/10.5281/zenodo.7906317.

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Tetracycline antibiotics were produced by systemic screening of soil microorganisms. The first member of the group was chlortetracycline derived from soil actinomycete   <em>Streptomyces aureofaciens</em> introduced in 1948. This was followed by oxytetracycline. Removal of chlorine atoms from chlortetracycline produced semi-synthetic tetracycline introduced in 1952. The further discovery led to other semi-synthetic tetracyclines like metacycline, doxycycline and rolitetracycline. Doxycycline and minocycline are relatively newer tetracyclines with high lipid solubility and a longer du

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4

Griffin, Michael O., Eduardo Fricovsky, Guillermo Ceballos, and Francisco Villarreal. "Tetracyclines: a pleitropic family of compounds with promising therapeutic properties. Review of the literature." American Journal of Physiology-Cell Physiology 299, no. 3 (2010): C539—C548. http://dx.doi.org/10.1152/ajpcell.00047.2010.

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There must be something unique about a class of drugs (discovered and developed in the mid-1940s) where there are more than 130 ongoing clinical trials currently listed. Tetracyclines were developed as a result of the screening of soil samples for antibiotic organisms. The first of these compounds chlortetracycline was introduced in 1948. Soon after their development tetracyclines were found to be highly effective against various pathogens including rickettsiae, Gram-positive, and Gram-negative bacteria, thus, becoming a class of broad-spectrum antibiotics. The mechanism of action of tetracycl

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Akimenko, Yuliya, Elizaveta Popova, Anna Fastova, Kamil Kazeev, and Sergey Kolesnikov. "Assessment of the ecological state of ordinary chernozem contaminated with antibiotics of tetracycline group." АгроЭкоИнфо 4, no. 52 (2022): 24. http://dx.doi.org/10.51419/202124424.

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The article presents the results of a comprehensive assessment of the ecological state of chernozem when contaminated with tetracyclines at concentrations of 10, 100 and 1000 mg/kg by the degree of change in biological indicators. It was found that tetracycline contamination leads to a deterioration in the ecological state of ordinary chernozem. The degree of change in biological parameters is determined by the chemical structure of tetracyclines and their concentration. A negative correlation relationship is established between the concentration of tetracyclines and the degree of change in bi

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6

Granados-Chinchilla, Fabio, and César Rodríguez. "Tetracyclines in Food and Feedingstuffs: From Regulation to Analytical Methods, Bacterial Resistance, and Environmental and Health Implications." Journal of Analytical Methods in Chemistry 2017 (2017): 1–24. http://dx.doi.org/10.1155/2017/1315497.

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Antibiotics are widely used as growth promoters in animal husbandry; among them, the tetracyclines are a chemical group of relevance, due to their wide use in agriculture, surpassing in quantities applied almost every other antibiotic family. Seeing the considerable amounts of tetracyclines used worldwide, monitoring of these antibiotics is paramount. Advances must be made in the analysis of antibiotics to assess correct usage and dosage of tetracyclines in food and feedstuffs and possible residues in pertinent environmental samples. The tetracyclines are still considered a clinically relevant

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7

Soory, M. "A Role for Non-Antimicrobial Actions of Tetracyclines in Combating Oxidative Stress in Periodontal and Metabolic Diseases: A Literature Review." Open Dentistry Journal 2, no. 1 (2008): 5–12. http://dx.doi.org/10.2174/1874210600802010005.

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This review addresses the role of adjunctive tetracycline therapy in the management of periodontal diseases and its efficacy in reducing inflammatory burden, oxidative stress and its sequelae in patients with coexisting features of metabolic syndrome. Removal of the dimethylamine group at C4 of the tetracycline molecule reduces its antibiotic properties, enhancing its non-antimicrobial actions; this strategy has aided the development of several chemically modified tetracyclines such as minocycline and doxycycline, by altering different regions of the molecule for focused action on biological t

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8

Abed, Dr Hayder H., Dr Adil H. Shebeeb, and Dr Raed A. Badea. "Chromatographic estimation of tetracycline in saliva." Mustansiria Dental Journal 5, no. 1 (2018): 47–52. http://dx.doi.org/10.32828/mdj.v5i1.502.

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Tetracyclines have been widely used in dentistry, especially in treatment of periodontal diseases and other oral pathological lesions. They are effective in treatment because their concentration in the gingival crevice is 2-10 times that in serum. In addition, several studies have demonstrated that tetracyclines at a low gingival crevicular fluid concentration (2-4 mg/ml) are very effective against many periodontal pathogens. Tetracyclines are an extensively used group of antibiotic medicines. Clinical pharmacology of tetracycline in saliva was not clear until the time of this research achievi

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9

Nguyen, Fabian, Agata L. Starosta, Stefan Arenz, Daniel Sohmen, Alexandra Dönhöfer, and Daniel N. Wilson. "Tetracycline antibiotics and resistance mechanisms." Biological Chemistry 395, no. 5 (2014): 559–75. http://dx.doi.org/10.1515/hsz-2013-0292.

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AbstractThe ribosome and protein synthesis are major targets within the cell for inhibition by antibiotics, such as the tetracyclines. The tetracycline family of antibiotics represent a large and diverse group of compounds, ranging from the naturally produced chlortetracycline, introduced into medical usage in the 1940s, to second and third generation semi-synthetic derivatives of tetracycline, such as doxycycline, minocycline and more recently the glycylcycline tigecycline. Here we describe the mode of interaction of tetracyclines with the ribosome and mechanism of action of this class of ant

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10

Golub, Lorne M., N. S. Ramamurthy, Thomas F. McNamara, Robert A. Greenwald, and Barry R. Rifkin. "Tetracyclines Inhibit Connective Tissue Breakdown: New Therapeutic Implications for an Old Family of Drugs." Critical Reviews in Oral Biology & Medicine 2, no. 3 (1991): 297–321. http://dx.doi.org/10.1177/10454411910020030201.

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Tetracyclines have long been considered useful adjuncts in peridontal therapy based on their antimicrobial efficacy against putative periodontopathogens. However, recently these drugs were found to inhibit mammalian collagenases and several other matrix metalloproteinases (MMPs) by a mechanism independent of their antimicrobial activity. Evidence is presented that this property may be therapeutically useful in retarding pathologic connective tissue breakdown, including bone resorption. The experiments leading to this discovery are described and possible mechanisms are addressed, including the

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11

Somani, Najwa, Gregory Bondy, and Richard I. Crawford. "Minocycline- and Tetracycline-Induced Hypertriglyceridemia in an HIV-Seropositive Patient Receiving Combination Antiretroviral Therapy." Journal of Cutaneous Medicine and Surgery 10, no. 3 (2006): 142–46. http://dx.doi.org/10.2310/7750.2006.00034.

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Background: Acne vulgaris may occur as part of immune reconstitution in human immunodeficiency virus (HIV)-seropositive patients on highly active antiretroviral therapy (HAART). Tetracyclines are a common acne treatment. Hypertriglyceridemia has not been reported as a side effect of this drug class. Objective: We report a case of an HIV-seropositive man on HAART (CD4 count 450 cells/μL) who developed isolated hypertriglyceridemia (> 13 mmol/L) after three separate challenges with minocycline or tetracycline, improving each time therapy was discontinued. Results: Based on a review of the lit

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12

Rusu, Aura, and Emanuela Lorena Buta. "The Development of Third-Generation Tetracycline Antibiotics and New Perspectives." Pharmaceutics 13, no. 12 (2021): 2085. http://dx.doi.org/10.3390/pharmaceutics13122085.

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The tetracycline antibiotic class has acquired new valuable members due to the optimisation of the chemical structure. The first modern tetracycline introduced into therapy was tigecycline, followed by omadacycline, eravacycline, and sarecycline (the third generation). Structural and physicochemical key elements which led to the discovery of modern tetracyclines are approached. Thus, several chemical subgroups are distinguished, such as glycylcyclines, aminomethylcyclines, and fluorocyclines, which have excellent development potential. The antibacterial spectrum comprises several resistant bac

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Truong, Thi Chau Giang, and Thi Minh Xuan Nguyen. "Tetracyclines-Resistant bacteria in Shrimps sold in major Supermarkets in Da Nang City, Vietnam." Research Journal of Biotechnology 20, no. 2 (2024): 79–85. https://doi.org/10.25303/202rjbt079085.

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The spread of tetracycline-resistant genes has posed a threat to the therapeutic effectiveness of tetracyclines. Misusing tetracyclines in seafood and shrimp farming has only accelerated this resistance process. Our study aimed to evaluate the status of tetracycline-resistant bacteria in shrimps and to evaluate the probability of spreading these antibiotic-resistant genes. The shrimp purchased from three major supermarkets in Da Nang city were analyzed and the results revealed that the ratio of bacteria resistant to tetracycline and oxytetracycline had a relatively high resistance rate of 4-11

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14

Chopra, Ian, and Marilyn Roberts. "Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance." Microbiology and Molecular Biology Reviews 65, no. 2 (2001): 232–60. http://dx.doi.org/10.1128/mmbr.65.2.232-260.2001.

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SUMMARY Tetracyclines were discovered in the 1940s and exhibited activity against a wide range of microorganisms including gram-positive and gram-negative bacteria, chlamydiae, mycoplasmas, rickettsiae, and protozoan parasites. They are inexpensive antibiotics, which have been used extensively in the prophlylaxis and therapy of human and animal infections and also at subtherapeutic levels in animal feed as growth promoters. The first tetracycline-resistant bacterium, Shigella dysenteriae, was isolated in 1953. Tetracycline resistance now occurs in an increasing number of pathogenic, opportunis

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15

Mukharlyamova, Aisylu Z., Aleksandr M. Saifutdinov, Elvira R. Rakhmetova, et al. "Processing of experimental data for the separation of chromatographic signals of tetracycline group antibiotics by mathematical modeling." Butlerov Communications 64, no. 12 (2020): 52–59. http://dx.doi.org/10.37952/roi-jbc-01/20-64-12-52.

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Antibiotics belonging to the classes of sulfonamides, amphenicols and tetracyclines, such as tetracycline, oxytetracycline and chlortetracycline, are used to control infectious diseases of honeybees. In addition, tetracycline group antibiotics can be added directly to plants during flowering. Contamination of the flower with high concentrations of antibiotics entails the risk of transferring antibiotic residues to honey. Consequently, these antibiotics persist as contaminants in honey, and the determination of these drugs in honey samples is of great importance. Tetracyclines have a broad spec

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16

Przeniosło-Siwczyńska, Monika, Ewelina Patyra, Aleksandra Grelik, Maja Chyłek-Purchała, Beata Kozak, and Krzysztof Kwiatek. "Contamination of Animal Feed with Undeclared Tetracyclines—Confirmatory Analysis by Liquid Chromatography–Mass Spectrometry after Microbiological Plate Test." Molecules 25, no. 9 (2020): 2162. http://dx.doi.org/10.3390/molecules25092162.

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The presence of tetracycline (TC) antibiotics was determined in animal feed that had been previously screened with a microbiological plate test. Feed samples were screened by a microbiological plate test on a pH 6.0 culture medium seeded with Bacillus cereus ATCC 11778 able to pre-reveal the presence of tetracyclines. Subsequently, confirmation and quantification were performed using a validated HPLC method with mass spectrometric detection. In 2013–2018, 353 feed samples were analysed to detect antibacterial substances, of which 186 (52.7%) were suspected to contain tetracyclines. Forty-two o

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17

Michalova, E., PNovotna, and J. Schlegelova. "Tetracyclines in veterinary medicine and bacterial resistance to them." Veterinární Medicína 49, No. 3 (2012): 79–100. http://dx.doi.org/10.17221/5681-vetmed.

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Since their discovery in 1945, tetracyclines have been used extensively in the therapy and prophylaxis of infectious diseases and as growth promoters. These wide applications have led to the equally fast spread of tetracycline resistant strains of gram-positive and gram-negative bacterial genera, including strains belonging to pathogenic as well as nonpathogenic species. Nonpathogenic bacteria could act as a reservoir of resistance determinants, which can be disseminated by horizontal transfer into pathogens. More than thirty different tetracycline resistance genes have been characterized. The

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18

Imamura, Takahisa, Kenji Matsushita, James Travis, and Jan Potempa. "Inhibition of Trypsin-Like Cysteine Proteinases (Gingipains) fromPorphyromonas gingivalis by Tetracycline and Its Analogues." Antimicrobial Agents and Chemotherapy 45, no. 10 (2001): 2871–76. http://dx.doi.org/10.1128/aac.45.10.2871-2876.2001.

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ABSTRACT Extracellular cysteine proteinases, referred to as gingipains, are considered important virulence factors for Porphyromonas gingivalis, a bacterium recognized as a major etiologic agent of chronic periodontitis. We investigated the effect of tetracycline and its analogues, doxycycline and minocycline, on the enzymatic activities of gingipains. Tetracyclines at 100 μM totally inhibited the amidolytic activity of arginine-specific gingipains (HRgpA and RgpB). In contrast, inhibition of Kgp was less efficient and required a somewhat higher concentration of the antibiotic to achieve the s

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19

Jetty, Pranitha, Soni Gaddam, and Satyanarayana S. V. Padi. "Emergence of Third Generation Tetracyclines: New Magic Bullets to Tackle Antibiotic Resistance in the Post-antibiotic Era." Asian Journal of Research in Infectious Diseases 13, no. 4 (2023): 1–14. http://dx.doi.org/10.9734/ajrid/2023/v13i4271.

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Tetracyclines are broad-spectrum antibiotics effective against a wide variety of microorganisms including bacteria, both Gram-positive and Gram-negative, mycoplasmas, rickettsiae, chlamydiae, and protozoan parasites. Owing to their broad-spectrum antimicrobial activities and inexpensiveness, tetracyclines have been used extensively in both human and animal infections and in animal feed as growth promoters. Owing to this, the global prevalence of antibiotic resistance, particularly of tetracyclines, for Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumonia

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KURITTU, JUSSI, STEFAN LÖNNBERG, MARKO VIRTA, and MATTI KARP. "Qualitative Detection of Tetracycline Residues in Milk with a Luminescence-Based Microbial Method: The Effect of Milk Composition and Assay Performance in Relation to an Immunoassay and a Microbial Inhibition Assay." Journal of Food Protection 63, no. 7 (2000): 953–57. http://dx.doi.org/10.4315/0362-028x-63.7.953.

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Performance of Tet-Lux, a newly developed microbiological test for the detection of tetracycline residues in raw milk, based on tetracycline-controlled luminescence activation of the test bacteria, was evaluated in bovine milks with variable amounts of somatic cells, bacteria, fat, protein, and natural inhibitory compounds. The sensitivity of Tet-Lux was also compared to a commercially available tetracycline immunoassay (Snap, Idexx Laboratories Inc.) and to a microbial inhibition test (Delvotest SP, Gist-Brogades). There were slight differences in the luminescence signals between different mi

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Kounatidis, Dimitris, Maria Dalamaga, Eugenia Grivakou, et al. "Third-Generation Tetracyclines: Current Knowledge and Therapeutic Potential." Biomolecules 14, no. 7 (2024): 783. http://dx.doi.org/10.3390/biom14070783.

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Tetracyclines constitute a unique class of antibiotic agents, widely prescribed for both community and hospital infections due to their broad spectrum of activity. Acting by disrupting protein synthesis through tight binding to the 30S ribosomal subunit, their interference is typically reversible, rendering them bacteriostatic in action. Resistance to tetracyclines has primarily been associated with changes in pump efflux or ribosomal protection mechanisms. To address this challenge, tetracycline molecules have been chemically modified, resulting in the development of third-generation tetracyc

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Zakeri, Bijan, and Gerard D. Wright. "Chemical biology of tetracycline antibioticsThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Systems and Chemical Biology, and has undergone the Journal's usual peer review process." Biochemistry and Cell Biology 86, no. 2 (2008): 124–36. http://dx.doi.org/10.1139/o08-002.

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For more than half a century, tetracycline antibiotics have been used to treat infectious disease. However, what once used to be a commonly prescribed family of antibiotics has now decreased in effectiveness due to wide-spread bacterial resistance. The chemical scaffold of the tetracyclines is a versatile and modifiable structure that is able to interact with many cellular targets. The recent availability of detailed molecular interactions between tetracycline and its cellular targets, along with an understanding of the tetracycline biosynthetic pathway, has provided us with a unique opportuni

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Jaroszewski, Jerzy, Niles Mamun, and Krzysztof Czaja. "Bidirectional Interaction between Tetracyclines and Gut Microbiome." Antibiotics 12, no. 9 (2023): 1438. http://dx.doi.org/10.3390/antibiotics12091438.

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The escalating misuse of antibiotics, particularly broad-spectrum antibiotics, has emerged as a pivotal driver of drug resistance. Among these agents, tetracyclines are widely prescribed for bacterial infections, but their indiscriminate use can profoundly alter the gut microbiome, potentially compromising both their effectiveness and safety. This review delves into the intricate and dynamic interplay between tetracyclines and the gut microbiome, shedding light on their reciprocal influence. By exploring the effects of tetracyclines on the gut microbiome and the impact of gut microbiota on tet

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Chukwudi, Chinwe U. "rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines." Antimicrobial Agents and Chemotherapy 60, no. 8 (2016): 4433–41. http://dx.doi.org/10.1128/aac.00594-16.

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ABSTRACTThe tetracycline antibiotics are known to be effective in the treatment of both infectious and noninfectious disease conditions. The 16S rRNA binding mechanism currently held for the antibacterial action of the tetracyclines does not explain their activity against viruses, protozoa that lack mitochondria, and noninfectious conditions. Also, the mechanism by which the tetracyclines selectively inhibit microbial protein synthesis against host eukaryotic protein synthesis despite conservation of ribosome structure and functions is still questionable. Many studies have investigated the bin

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KONDO, FUSAO, SEIJI MORIKAWA, and SUSUMU TATEYAMA. "Simultaneous Determination of Six Tetracyclines in Bovine Tissue, Plasma and Urine by Reverse-Phase High-Performance Liquid Chromatography." Journal of Food Protection 52, no. 1 (1989): 41–44. http://dx.doi.org/10.4315/0362-028x-52.1.41.

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A simple and rapid high-performance liquid chromatographic method was developed for the simultaneous separation and identification of six different tetracycline antibiotics (minocycline, oxytetracycline, tetracycline, dimethylchlortetracycline, chlortetracycline, and methacycline) in bovine kidney, plasma and urine. The antibiotics were separated at ambient temperature on a μ-Bondapak C18 column using a mobile phase [water 760 ml, acetonitrile 240 ml, N,N′-dimethylfolmamine 60 ml, ethanolamine 5.0 ml and Na2HPO4 5.2 g, pH 2.5] at a flow rate of 1.5 ml/min. A variable-wavelength detector set at

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Batool, Zahra, Ivan B. Lomakin, Yury S. Polikanov, and Christopher G. Bunick. "Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome." Proceedings of the National Academy of Sciences 117, no. 34 (2020): 20530–37. http://dx.doi.org/10.1073/pnas.2008671117.

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Sarecycline is a new narrow-spectrum tetracycline-class antibiotic approved for the treatment of acne vulgaris. Tetracyclines share a common four-ring naphthacene core and inhibit protein synthesis by interacting with the 70S bacterial ribosome. Sarecycline is distinguished chemically from other tetracyclines because it has a 7-[[methoxy(methyl)amino]methyl] group attached at the C7 position of ring D. To investigate the functional role of this C7 moiety, we determined the X-ray crystal structure of sarecycline bound to theThermus thermophilus70S ribosome. Our 2.8-Å resolution structure reveal

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Mavritsakis, Nikolaos, Vasile Emil Ursu, Elena Ionescu, and Anca Ganescu. "Actual Study Regarding Quantitative Determination of Tetracyclines by Electrical Analysis Techniques and Methods Potentiometric sensors for tetracycline." Revista de Chimie 70, no. 2 (2019): 671–75. http://dx.doi.org/10.37358/rc.19.2.6982.

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Ion-selective electrodes have gained a wide applicability in pharmaceutical analysis and the literature has some data and their use for the determination of tetracyclines. Ion-selective electrodes for tetracycline were built using different electroactive materials and studied their performance. A working group from the Department of Analytical Chemistry of the University of Bucharest, in collaboration with a group of teaching staff from the Department of Chemistry at the Faculty of Sciences, University of Craiova, has developed and tested a series of ion-selective electrodes for tetracycline,

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Le Roy, Chloé, Arabella Touati, Carla Balcon, et al. "Identification of 16S rRNA mutations in Mycoplasma genitalium potentially associated with tetracycline resistance in vivo but not selected in vitro in M. genitalium and Chlamydia trachomatis." Journal of Antimicrobial Chemotherapy 76, no. 5 (2021): 1150–54. http://dx.doi.org/10.1093/jac/dkab016.

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Abstract Objectives Tetracyclines are widely used for the treatment of bacterial sexually transmitted infections (STIs) and recently have been used successfully for post-exposure prophylaxis of STIs in MSM. We investigated the in vitro and in vivo development of tetracycline resistance in Chlamydia trachomatis and Mycoplasma genitalium and evaluated 16S rRNA mutations associated with acquired resistance in other bacteria. Methods In vitro selection of resistant mutants of reference strains of C. trachomatis and M. genitalium was undertaken by serial passage in medium containing subinhibitory c

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Ustinova, Maria N., and Kseniia A. Filippova. "Oxidative degradation of tetracyclines." Izvestiya of Saratov University. Chemistry. Biology. Ecology 25, no. 1 (2025): 23–33. https://doi.org/10.18500/1816-9775-2025-25-1-23-33.

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Environmental pollution is one of the most pressing problems facing humanity. The constant search for its solution is an important aspect of modern chemistry. The work studied the oxidative degradation of two antibiotics of the same pharmaceutical group, with a similar structure but different properties. The purpose of this work was to study the oxidation process of the active substances of two antibiotics: tetracycline and doxycycline by various oxidative and combined systems: the Fenton system, the Ruff system, their combined action, their action in the presence of EDTA, as well as under the

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Furkhatovich, Farkhatov Sunnatillokhan, and Akhmedov Alisher Astanovich. "TETRACYCLINE TEETH." Journal of Social Sciences and Humanities Research Fundamentals 4, no. 11 (2024): 77–85. http://dx.doi.org/10.55640/jsshrf-04-11-12.

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Tetracyclines have been developed as broad-spectrum antibiotics that can be used to treat common infections in children and adults. One of the side effects of this group of substances is their incorporation into tissues with the formation of calcinates. The first mention of the discoloration of teeth in children caused by tetracyclines dates back to 1956, and subsequently a number of reports appeared in which tetracycline led to enamel hypoplasia. Nowadays, it is known that this group of antibiotics has the ability to chelate calcium ions and thus integrate into teeth, cartilage and bones. Alt

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Attur, Mukundan G., Rajesh N. Patel, Prakash D. Patel, Steven B. Abramson, and Ashok R. Amin. "Tetracycline Up-Regulates COX-2 Expression and Prostaglandin E2 Production Independent of Its Effect on Nitric Oxide." Journal of Immunology 162, no. 6 (1999): 3160–67. http://dx.doi.org/10.4049/jimmunol.162.6.3160.

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Abstract Tetracyclines (doxycycline and minocycline) augmented (one- to twofold) the PGE2 production in human osteoarthritis-affected cartilage (in the presence or absence of cytokines and endotoxin) in ex vivo conditions. Similarly, bovine chondrocytes stimulated with LPS showed (one- to fivefold) an increase in PGE2 accumulation in the presence of doxycycline. This effect was observed at drug concentrations that did not affect nitric oxide (NO) production. In murine macrophages (RAW 264.7) stimulated with LPS, tetracyclines inhibited NO release and increased PGE2 production. Tetracycline(s)

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Patyra, Ewelina, and Krzysztof Kwiatek. "Analytical procedure for the determination of tetracyclines in medicated feedingstuffs by liquid chromatography-mass spectrometry." Journal of Veterinary Research 60, no. 1 (2016): 35–41. http://dx.doi.org/10.1515/jvetres-2016-0006.

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Abstract Introduction: The article presents a rapid and simple analytical procedure for determination of four tetracyclines (oxytetracycline, tetracycline, chlortetracycline, and doxycycline) in animal medicated feedingstuffs. Material and Methods: Two-gramme samples were extracted by a Na2EDTA-McIlvaine buffer (pH 4)/methanol mixtures (40/60, v/v). The determination was achieved by liquid chromatography using a Zorbax Eclipse XDB C18 analytical column with mass spectrometer detection (LC-MS). Results: Recoveries of the antibiotics from spiked feed samples ranged from 78.2% to 113.5%. The LOD

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BOSMAN, A. B., J. A. WAGENAAR, J. A. STEGEMAN, J. C. M. VERNOOIJ, and D. J. MEVIUS. "Antimicrobial resistance in commensalEscherichia coliin veal calves is associated with antimicrobial drug use." Epidemiology and Infection 142, no. 9 (2013): 1893–904. http://dx.doi.org/10.1017/s0950268813002665.

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SUMMARYThe aim of this study was to determine the association between farm management factors, including antimicrobial drug usage, and resistance in commensalEscherichia coliisolates from the faeces of white veal calves. NinetyE. coliisolates from one pooled sample per farm (n = 48) were tested for their phenotypical resistance against amoxicillin, tetracycline, cefotaxime, ciprofloxacin and trimethoprim/sulfamethoxazole (TMP/SMX). Logistic regression analysis revealed the following risk factors (P < 0·05); farmer wearing the same work clothes for several days [ciprofloxacin, odds ratio (OR

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Hamilton, Leslie A., and Anthony J. Guarascio. "Tetracycline Allergy." Pharmacy 7, no. 3 (2019): 104. http://dx.doi.org/10.3390/pharmacy7030104.

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Despite the widespread use of tetracycline antibiotics since the late 1940s, tetracycline hypersensitivity reactions have rarely been described in the literature. A comprehensive PubMed search was performed, including allergic and serious adverse reactions attributed to the tetracyclines class of antibiotics. Of the evaluated tetracycline analogs, minocycline was attributed to the greatest overall number and severity of serious adverse events reported in the literature, with notable reactions primarily reported as respiratory and dermatologic in nature. Reactions to tetracycline have also been

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Swallow, Madisen A., Ryan Fan, Jeffrey M. Cohen, and Christopher G. Bunick. "Antibiotic Resistance Risk with Oral Tetracycline Treatment of Acne Vulgaris." Antibiotics 11, no. 8 (2022): 1032. http://dx.doi.org/10.3390/antibiotics11081032.

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Almost 1 billion people worldwide have acne, and oral tetracyclines, including doxycycline and minocycline, are effective and frequently prescribed treatments for acne. However, there is growing concern for the development of antibiotic resistance with such widespread utilization by dermatologists. Additionally, tetracyclines are known to have various potential side effects, including gut dysbiosis, gastrointestinal upset, photosensitivity, dizziness, and vertigo. However, in 2018 a novel narrow-spectrum tetracycline, sarecycline, was Food and Drug Administration-approved to treat moderate-to-

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Passadi, Kalliroi-Antonia, Zoi Fryda, Panagiotis Lepetsos, and Christos P. Zafeiris. "Role of Tetracyclines in Joint Arthroplasties." European Journal of Medical and Health Sciences 6, no. 4 (2024): 15–21. http://dx.doi.org/10.24018/ejmed.2024.6.4.2145.

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Tetracyclines have various connections to total joint arthroplasties, including their potential use in perioperative infection prophylaxis, treatment of periprosthetic infections and mitigation of complications such as osteolysis and aseptic loosening. The present study is a narrative review focusing on the potential association of tetracyclines with joint arthroplasties. Tetracyclines have several potential uses in the context of arthroplasties, although they are not commonly used as prophylactic antibiotics during surgery due to concerns about their efficacy against the typical pathogens ass

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Pavelquesi, Sabrina Lunara Santos, Ana Carolina Almeida de Oliveira Ferreira, Angeislenie Ricelle Magalhães Rodrigues, Calliandra Maria de Souza Silva, Daniela Castilho Orsi, and Izabel Cristina Rodrigues da Silva. "Presence of Tetracycline and Sulfonamide Resistance Genes in Salmonella spp.: Literature Review." Antibiotics 10, no. 11 (2021): 1314. http://dx.doi.org/10.3390/antibiotics10111314.

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Tetracyclines and sulfonamides are broad-spectrum antibacterial agents which have been used to treat bacterial infections for over half a century. The widespread use of tetracyclines and sulfonamides led to the emergence of resistance in a diverse group of bacteria. This resistance can be studied by searching for resistance genes present in the bacteria responsible for different resistance mechanisms. Salmonella is one of the leading bacteria causing foodborne diseases worldwide, and its resistance to tetracyclines and sulfonamides has been widely reported. The literature review searched the V

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Miroshnikova, Maria Sergeevna, Elena Petrovna Miroshnikova, Azamat Ersainovich Arinzhanov, and Yuliya Vladimirovna Kilyakova. "Application of antibiotics in agriculture and alternatives of their use." Agrarian Scientific Journal, no. 5 (May 26, 2021): 65–70. http://dx.doi.org/10.28983/asj.y2021i5pp65-70.

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The use of antibiotics in medicine, plant growing and animal husbandry has led to the spread of bacterial resistance to antimicrobial drugs. Tetracyclines are a chemical group of great importance due to the widespread use of these preparations in agriculture. Due to the fact that significant quantities of tetracycline antimicrobial drugs are used all over the world, their monitoring plays an important role. Therefore, progress needs to be made in antibiotic analysis to assess the correct use and dosage of tetracyclines in food and feed, as well as possible residues in relevant environmental sa

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Tyczkowska, Krystyna, and Arthur L. Aronson. "Simultaneous Liquid Chromatographic Determination of Some Tetracyclines in Serum." Journal of AOAC INTERNATIONAL 69, no. 5 (1986): 760–62. http://dx.doi.org/10.1093/jaoac/69.5.760.

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Abstract A sensitive liquid chromatographic method has been developed for the simultaneous determination of oxytetracycline, minocycline, tetracycline, and doxycycline in serum. A serum sample is vortex-mixed with a solution of mobile phase for tetracyclines and 2% (v/v) phosphoric acid. The mixture is filtered using a 30 000 molecular weight cutoff microseparation tube which separates high-molecular-weight solutes following low-speed centrifugation. Tetracyclines are separated from other serum components by reverse phase liquid chromatography (LC) with buffered methanol mobile phase. Ultravio

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Curtis, Ronald D., and Roderick E. Wasylishen. "A nitrogen-15 nuclear magnetic resonance study of the tetracycline antibiotics." Canadian Journal of Chemistry 69, no. 5 (1991): 834–38. http://dx.doi.org/10.1139/v91-123.

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Natural abundance 15N NMR has been used to study several tetracycline antibiotics in the solid state and in solution. In the solid state, the 15N chemical shifts of the tetracycline free bases are sensitive to the site of protonation in the "A" ring. A high frequency shift of 14 ppm is observed for the keto form of oxytetracycline (N protonated) relative to the enol form of oxytetracycline (O protonated). Comparison of 15N chemical shifts in the solid and solution states indicates for the first time that the structural integrity (site of protonation and hence conformation) of the tetracyclines

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Marquez, Johana, Albeiro Marrugo Padilla, Darío Méndez Cuadro та Erika Rodríguez Cavallo. "Residues of tetracyclines and β-lactams antibiotics induce carbonylation of chicken breast". F1000Research 10 (15 липня 2021): 575. http://dx.doi.org/10.12688/f1000research.53863.1.

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Background: Worldwide, chicken meat is widely consumed due to its low cost, high nutritional value and non-interference with religious or cultural beliefs. However, during animal husbandry chickens are exposed to many chemical substances, including tetracyclines and β-lactams, which are used to prevent and cure several infections. Some residues of these compounds may bioaccumulate and be present in chicken meat after slaughtering, promoting oxidative reactions. Methods: In order to evaluate in vitro carbonylation induced by tetracyclines and β-lactams residues, a proteomic approach was used. F

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Alanen, Virve, Sanna Iivanainen, Martti Arffman, and Jussi Pekka Koivunen. "Tetracyclines increase the survival of NSCLC patients treated with EGFR TKIs: a retrospective nationwide registry study." ESMO Open 5, no. 5 (2020): e000864. http://dx.doi.org/10.1136/esmoopen-2020-000864.

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BackgroundWith the first and second-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), clinical benefit and rash correlate together. EGFR TKI-induced rash can be alleviated with tetracyclines, but it is unknown whether the use of tetracyclines can increase the survival of non-small-cell lung cancer (NSCLC) patients treated with EGFR TKIs.MethodsWe collected all the patients (n=1271) who had reimbursement for EGFR TKIs (gefitinib, erlotinib and afatinib) in Finland 2011–2016, had purchased TKIs, and had data available at nationwide cancer registry. The surviva

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Long, Dengying, Jingdong Peng, Huanjun Peng, et al. "A quadruple-channel fluorescent sensor array based on label-free carbon dots for sensitive detection of tetracyclines." Analyst 144, no. 10 (2019): 3307–13. http://dx.doi.org/10.1039/c9an00148d.

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A quadruple-channel fluorescent sensor array based on label-free carbon dots (CDs) was fabricated to detect and discriminate a series of tetracyclines (TCs), including chlortetracycline (CTC), oxytetracycline (OTC), tetracycline (TC) and doxycycline (DOX).

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Dégrange, S., H. Renaudin, A. Charron, C. Bébéar, and C. M. Bébéar. "Tetracycline Resistance in Ureaplasma spp. and Mycoplasma hominis: Prevalence in Bordeaux, France, from 1999 to 2002 and Description of Two tet(M)-Positive Isolates of M. hominis Susceptible to Tetracyclines." Antimicrobial Agents and Chemotherapy 52, no. 2 (2007): 742–44. http://dx.doi.org/10.1128/aac.00960-07.

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ABSTRACT Twenty-four of 128 clinical isolates of Mycoplasma hominis and 6 of 276 clinical isolates of Ureaplasma spp. from Bordeaux, France (1999 to 2002), were resistant to tetracycline and harbored the tet(M) gene. For M. hominis, we also found an increase in tetracycline resistance and two tet(M)-positive isolates that were susceptible to tetracyclines.

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Grada, Ayman, Mahmoud A. Ghannoum, and Christopher G. Bunick. "Sarecycline Demonstrates Clinical Effectiveness against Staphylococcal Infections and Inflammatory Dermatoses: Evidence for Improving Antibiotic Stewardship in Dermatology." Antibiotics 11, no. 6 (2022): 722. http://dx.doi.org/10.3390/antibiotics11060722.

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Tetracycline class antibiotics are widely used for multiple skin diseases, including acne vulgaris, acne rosacea, cutaneous infections, inflammatory dermatoses, and autoimmune blistering disorders. Concerns about antibiotic resistance and protecting the human/host microbiome beg the question whether broad-spectrum tetracyclines such as doxycycline and minocycline should be prescribed at such a high rate by dermatologists when a narrow-spectrum tetracycline derivative, sarecycline, exists. We evaluated the clinical effectiveness of oral sarecycline against cutaneous staphylococcal infections, e

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Klein, Natalie C., and Burke A. Cunha. "Tetracyclines." Medical Clinics of North America 79, no. 4 (1995): 789–801. http://dx.doi.org/10.1016/s0025-7125(16)30039-6.

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SALTER, ROBERT, STEVEN HOLMES, DAVID LEGG, JOEL COBLE та BRUCE GEORGE. "Hog Charm II Tetracycline Test Screening Results Compared with a Liquid Chromatography Tandem Mass Spectrometry 10-μg/kg Method". Journal of Food Protection 75, № 2 (2012): 405–7. http://dx.doi.org/10.4315/0362-028x.jfp-11-294.

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Pork tissue samples that tested positive and negative by the Charm II tetracycline test screening method in the slaughter plant laboratory were tested with the modified AOAC International liquid chromatography tandem mass spectrometry (LC-MS-MS) method 995.09 to determine the predictive value of the screening method at detecting total tetracyclines at 10 μg/kg of tissue, in compliance with Russian import regulations. There were 218 presumptive-positive tetracycline samples of 4,195 randomly tested hogs. Of these screening test positive samples, 83% (182) were positive, &gt;10 μg/kg by LC-M

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Gavilán, Rosa E., Carolina Nebot, Maria Veiga-Gómez, et al. "A Confirmatory Method Based on HPLC-MS/MS for the Detection and Quantification of Residue of Tetracyclines in Nonmedicated Feed." Journal of Analytical Methods in Chemistry 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/1202954.

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The Commission Regulation 574/2011/EC set up maximum levels of coccidiostats and histomonostats in nonmedicated feed as a consequence of carry-over during manufacturing. Carry-over takes place from medicated to nonmedicated feed during feed production. Similar contamination could also occur for other pharmaceuticals such as tetracyclines, a group of antibiotics commonly employed in food production animal. The objective of this work is to present a simple and fast method for the simultaneous detection of four tetracyclines (chlortetracycline, doxycycline, oxytetracycline, and tetracycline) in n

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Bidell, Monique R., Manjunath (Amit) P. Pai, and Thomas P. Lodise. "Use of Oral Tetracyclines in the Treatment of Adult Patients with Community-Acquired Bacterial Pneumonia: A Literature Review on the Often-Overlooked Antibiotic Class." Antibiotics 9, no. 12 (2020): 905. http://dx.doi.org/10.3390/antibiotics9120905.

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Oral tetracyclines have been used in clinical practice for over 60 years. Overall, one of the most common indications for use of oral tetracyclines is for treatment of adult outpatients with lower respiratory tract infections, including community-acquired pneumonia (CAP). Despite the longstanding use of oral tetracyclines, practice patterns indicate that they are often considered after other guideline-concordant oral CAP treatment options (namely macrolides, fluoroquinolones, and β-lactams). However, there are growing resistance or safety concerns with the available oral agents listed for outp

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Bri, Edin De, and Wei Lei. "BIOCHEMICAL AND HISTOLOGICAL EFFECTS OF TETRACYCLINES ON SPONTANEOUS OSTEOARTHRITIS IN GUINEA PIGS." Image Analysis & Stereology 19, no. 2 (2011): 125. http://dx.doi.org/10.5566/ias.v19.p125-131.

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Matrix metalloproteinases (MMPs) are mediators in connective tissue destruction in a variety of pathologic processes. Recently discovered chemically modified tetracyclines have been found to be effective inhibitors of MMP mediated connective tissue degradation in both rheumatoid arthritis (RA) and osteoarthritis (OA). The Hartley guinea pig model has been described with a high incidence of spontaneous OA-like changes in the knee joint. Therefore we have studied the effect of two tetracyclines, doxycycline (Dox) and chemically modified tetracycline-7 (CMT-7) which have both previously been show

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