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Dissertations / Theses on the topic 'TGF-β Pathway'

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Published: 4 June 2021

Last updated: 26 July 2025

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1

Kowanetz, Marcin. "Novel Regulators of the TGF-β Signaling Pathway". Doctoral thesis, Uppsala University, Ludwig Institute for Cancer Research, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5891.

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<p>The transforming growth factor-β (TGF-β) superfamily consists of related multifunctional cytokines, which include TGF-βs, activins, and bone morphogenetic proteins (BMPs) and coordinate several biological responses in diverse cell types. The biological activity of TGF-β members is executed by transmembrane serine/threonine kinase receptors and intracellular Smad proteins. The effects of TGF-β on the epithelium are of high interest. Carcinomas (tumors of epithelial origin) are the most common type of human cancer and frequently exhibit aberrant responses to TGF-β. Therefore, TGF-β can be def

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2

Sheils, Emma. "The TGF-β signalling pathway in Trichinella spiralis : phylogenetic and functional analysis of TGF-β ligands". Thesis, University of Aberdeen, 2011. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=184012.

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The release of genome sequence information is revolutionising the study of helminth parasites by providing important datasets for comparative genomics, allowing the comprehensive analysis of signalling pathways that regulate nematode development. Much of the current knowledge of nematode signalling pathways is based on studies of the free-living model Caenorhabditis elegans. The recent availability of the Trichinella spiralis genome sequence presented an opportunity to study signalling pathways of this, and other, parasitic nematodes, providing a phylum-wide overview of a given signalling path

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Rodón, Ahnert Laura. "Hyperactivation of the TGF-β signaling pathway in glioblastoma: mechanisms and consequences". Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/96417.

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The TGF-β pathway is currently considered a therapeutic target in advanced tumors, including glioblastoma (GBM), and several anti-TGFβ agents are in clinical trials and have shown promising results .A thorough understanding of the molecular mechanisms involved in the protumorigenic function of TGF-β will facilitate the identification of markers of response that can be used to stratify patients to be treated with anti-TGFβ compounds and, moreover, will allow for the discovery of new therapeutic agents. TGF-β is highly active in high-grade glioma, and elevated TGF-β activity confers poor prog

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Kimbrough-Allah, Mawiyah. "Regulation of the PI3-Kinase/PTEN Signaling Pathway by TGF-β in Prostate Cancer Cells". DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2018. http://digitalcommons.auctr.edu/cauetds/123.

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Transforming growth factor -β (TGF-β) plays an important role in the progression of prostate cancer. It acts as a tumor suppressor in normal epithelial cells but as a tumor promoter in advanced prostate cancer cells. The PI3-kinase pathway has been shown to play integral roles in many cellular processes including cell proliferation, survival, and cell migration in many cell types. PI3-kinase pathway mediates TGF-β effects on prostate cancer cell migration and invasion. Phosphatase and tensin homolog (PTEN), a tumor suppressor gene, inhibits PI3-kinase pathway and is frequently mutated in prost

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Zieba, Agata. "Application of Proximity Ligation Assay for Multidirectional Studies on Transforming Growth Factor-β Pathway". Doctoral thesis, Uppsala universitet, Molekylära verktyg, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-171952.

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A comprehensive understanding of how the body and all its components function is essential when this knowledge is exploited for medical purposes. The achievements in biological and medical research during last decades has provided us with the complete human genome and identified signaling pathways that governs the cellular processes that facilitates the development and maintenance of higher order organisms. This has brought about the realization that diseases such as cancer is a consequence of genomic aberrations that effects these signaling pathways, endowing cancer cells with the capacity to

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6

Cepeda, Edgar B. "Mechanisms regulating CXCR4 intracellular traffic and polarization in human hepatocellular carcinoma cells: cross-talk with the TGF-β pathway". Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/667580.

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CXCR4 is a chemokine receptor originally discovered and cloned in leukocytes that functions by controling the migration to the inflammatory foci. The CXCR4 chemokine receptor and its ligand, SDF-1α (also named CXCL12), are two important molecules involved in the crosstalk between cancer cells and the microenvironment, which has a relevant role in tumour progression, and consequently are considered as promising targets for cancer therapy. The CXCR4/SDF-1α axis is implicated in the expansion and progression of a wide variety of tumors, including prostate, oesophageal, and liver cancer, among oth

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Zhou, Fa Yang. "Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SirT3-TGF-β-Smad signaling pathway". Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952122.

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8

Boneva, Stefaniya Konstantinova [Verfasser], Barbara [Akademischer Betreuer] Braunger та Frank [Akademischer Betreuer] Schweda. "Characterization of the Neuroprotective Function of the TGF-β Signaling Pathway in the Retina / Stefaniya Konstantinova Boneva ; Barbara Braunger, Frank Schweda". Regensburg : Universitätsbibliothek Regensburg, 2018. http://d-nb.info/115360647X/34.

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9

Ganapathy, Anuradha. "The role of the TGF-β signal transduction pathway in the development and progression of human squamous cell carcinoma of the skin". Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.503878.

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This study examined whether the transforming growth factor-β (TGF-P) signalling pathway switches from a tumour suppressing to a pro-metastatic function during the progression of human squamous cell carcinoma (SCC). Preliminary studies aimed to determine whether the HaCaT model of human SCC together with the in vivo technique of floor of the mouth (FOM) transplantation of cells to athymic mice provided a good model of human SCC. Following FOM inoculation, HaCaT was non-tumorigenic while the remaining cell lines displayed an increasingly aggressive phenotype in vivo confirming that the HaCaT mod

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10

Liu, Ye. "Generation and utilization of knockout mice to elucidate the functions of the TGF-β pathway in mammalian endodermal specification and placental development". The Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=osu1158673346.

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11

Verga-Gerard, Amandine. "Perturbation de la voie de signalisation du TGF-β par les protéines du virus de l'hépatite C , impact sur la carcinogenèse". Phd thesis, Ecole normale supérieure de lyon - ENS LYON, 2012. http://tel.archives-ouvertes.fr/tel-00780332.

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L'infection chronique par le virus de l'hépatite C (VHC) conduit au développement de pathologies hépatiques, telles que la fibrose dont le terme évolutif est la cirrhose sur laquelle peut se développer un carcinome hépatocellulaire. Les observations cliniques indiquent que le VHC interfère avec la voie de signalisation du Transforming Growth Factor β (TGFβ). Entre autres fonctions, cette cytokine induit la transition épithélio-mésenchymateuse (EMT), ce qui favorise la migration cellulaire et l'invasion tumorale. Le but de cette thèse est d'analyser l'impact des protéines non structurales du VH

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Corsin-Jimenez, Marta. "The role of Notch and TGF-β pathways in CD4+ T cell responses". Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23311.

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Notch receptors (1 to 4) are highly conserved cell surface molecules that bind two different families of ligands, Delta (1, 3 and 4) and Serrate (1 and 2, Jagged in vertebrates). Notch signalling plays a fundamental role in cell fate decisions during embryogenesis in both invertebrates and vertebrates, the best-characterised example of this is neurogenesis in <i>Drosophila.</i> This process involves the specification of neural versus epidermal precursors. The aim of this study was to investigate further the potential role of components of the Notch pathway and TGF-β superfamily members in CD4<

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Qiu, Qingchao. "TGF-β, WNT, AND FGF SIGNALING PATHWAYS DURING AXOLOTL TAIL REGENERATION AND FORELIMB BUD DEVELOPMENT". UKnowledge, 2019. https://uknowledge.uky.edu/neurobio_etds/24.

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Tgf-β, Wnt, and Fgf signaling pathways are required for many developmental processes. Here, I investigated the requirement of these signaling pathways during tail regeneration and limb development in the Mexican axolotl (Ambystoma mexicanum). Using small chemical inhibitors during tail regeneration, I found that the Tgf-β signaling pathway was required from 0-24 and 48-72 hours post tail amputation (hpa), the Wnt signaling pathway was required from 0-120 hpa, and the Fgf signaling pathway was required from 0-12hpa. Tgf-β1 was upregulated after amputation and thus may mediate Tgf-β signaling pa

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Sharmin, Nahid. "Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension". Thesis, University of Bradford, 2018. http://hdl.handle.net/10454/17177.

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Vascular remodelling due to excessive proliferation and apoptosis resistance of pulmonary arterial smooth muscle (PASMCs) and endothelial cells (ECs) has been attributed to the pathogenesis of pulmonary arterial hypertension (PAH). It is an incurable cardiovascular disorder, which leads to right heart failure and death, if left untreated. Heterozygous germline mutations in the bone morphogenetic protein receptor type II (BMPR2) have been linked with the majority (~75%) of the familial form of the disease (HPAH). Mutations in the BMPR2 gene impinge upon the BMP signalling which perturbs

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López, Luque Judit. "New insights into the crosstalk between the TGF-β and the EGF Receptor pathways during liver regeneration and hepatocarcinogenesis". Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/586393.

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Transforming growth factor-beta (TGF-β) is an important growth suppressor in hepatocytes, inhibiting proliferation and inducing cell death. However, it also plays a role in other processes such as epithelial-to-mesenchymal transition (EMT), which contributes to tumour invasion and progression. Epidermal Growth Factor Receptor (EGFR) belongs to the kinase receptor family, and it is involved in cell proliferation, survival, differentiation and adhesion. Aiming to study the connection between both pathways, different animal and cellular models have been generated in our group. The in vivo model i

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Hasan, Md Maruf [Verfasser], та Ingo [Akademischer Betreuer] Kleiter. "Regulation of T cell differentiation by the TGF-β inhibitor Smad7 and non-Smad pathways / Md. Maruf Hasan. Betreuer: Ingo Kleiter". Regensburg : Universitätsbibliothek Regensburg, 2013. http://d-nb.info/1037021169/34.

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Felgueiras, Juliana Carina Cardoso. "The role of TCTEX1D4/PPP1 complex in cell proliferation and migration." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12507.

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Mestrado em Biomedicina Molecular<br>Prostate cancer is one of the most prevalent and incident cancer in men, being a disquieting cause of men’s death worldwide. The widespread implementation of prostate-specific antigen (PSA) screening and the improvements on prostate cancer therapy have been leading to a markedly decrease in mortality. However, PSA use is controversial since it has been leading to the diagnosis and treatment of several prostate cancer cases that would not otherwise cause symptoms or threaten man’s life. Hence, the establishment of a panel of biomarkers and the discovery of

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Ng, Yee-Yung, та 吳義勇. "Treatment of Kidney Disease by Targeting TGF-β Signaling Pathway". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/kdag32.

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博士<br>國立陽明大學<br>臨床醫學研究所<br>97<br>The number of patients on renal replacement therapy due to the progression of chronic kidney disease has gradually increased over the last decades, and the number of patients on renal replacement therapy is predicted to double during the next 10 years. This trend is even more pronounced in Taiwan. Therefore, reduction in the incidence of end-stage renal disease by intervention in early stages of chronic kidney disease to prevent or slow the progression of chronic kidney disease has become important and urgently needed. Regardless of the initial insults leading

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WANG, ERH-HSIANG, та 王爾祥. "Arecoline Induces LOXL2 Expression via TGF-β Pathway in Buccal Fibroblasts". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/a9gqt2.

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碩士<br>國立臺灣大學<br>口腔生物科學研究所<br>106<br>Lysyl oxidase like protein 2 (LOXL2) is an extracellular copper-dependent amine oxidase that catalyses the cross-linking of collagens and elastin. It has recently been reported to serve a key role in hepatic, renal, and pulmonary fibrosis. Areca nut (AN) chewing is the most important etiological factor in the pathogenesis of oral submucous fibrosis (OSF). We examined the expression of LOXL2 protein in 7 cases of OSF and found elevated LOXL2 staining in fibroblasts and epithelial cells in 6 cases. Arecoline, a main alkaloid found in the areca nut, stimulated

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Sharmin, Nahid, Chinyere C. Nganwuchu та Md Talat Nasim. "Targeting the TGF-β signaling pathway for resolution of pulmonary arterial hypertension". 2021. http://hdl.handle.net/10454/18507.

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Yes<br>Aberrant transforming growth factor-β (TGF-β) signaling activation is linked to pulmonary arterial hypertension (PAH). BMPR2 mutations perturb the balance between bone morphogenetic protein (BMP) and TGF-β pathways, leading to vascular remodeling, narrowing of the lumen of pulmonary vasculature, and clinical symptoms. This forum highlights the association of the TGF-β pathway with pathogenesis and therapeutic approaches.<br>Research carried out at Nasim laboratories is funded by GrowMedtech, the Royal Society, the Commonwealth Scholarship Commission (CSC) and the University of Bradford

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Wei, Ho-Chun, та 魏荷君. "Studies on the signal transduction pathway of TGF-β in human hepatoma cells". Thesis, 1994. http://ndltd.ncl.edu.tw/handle/10565459716610606868.

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Pei-SyuanWu та 吳沛萱. "The role of 58-kDa microspherule protein (MSP58) in TGF-β signaling pathway". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/92d2a2.

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Yang, Wen-Hao, та 楊文豪. "Aryl Hydrocarbon Receptor Inhibits TGF-β Pathway through Smad4 Degradation in Human Lung Carcinoma". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/62575323223643780238.

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碩士<br>國立臺灣大學<br>毒理學研究所<br>103<br>Backgrounds: The aryl hydrocarbon receptor (AhR) is a ligand-dependent-activated transcriptional factor that forms a complex with its ligand such as TCDD to activate target genes Epithelial to mesenchymal transition (EMT) is a process that epithelial cells are converted to invasive mesenchymal cells, and this process involved tumor metastasis from original cancer to distal. The role of ligand-independent AhR function in cell EMT was investigated in this study. Results: Epithelial markers were induced and mesenchymal markers were inhibited in AhR-overexpressed c

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Chih-HauSu та 蘇秉驊. "Overexpression of prothymosin α induces pulmonary emphysema by inhibition of TGF-β signalling pathway". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/52654485912178620936.

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博士<br>國立成功大學<br>基礎醫學研究所<br>98<br>Emphysema is the major type of chronic obstructive pulmonary disease (COPD), characterised by permanent airflow restriction resulting from enlargement of alveolar airspace and loss of lung elasticity. Despite being the main risk factor, only about 20% of cigarette smokers develop emphysema. Therefore, there may be unidentified genes which predispose to smoking-induced emphysema. Prothymosin α (ProT) is an acidic protein associated with cell proliferation, apoptosis, oxidative stress, immunomodulation and acetylation. Despite its many effects, the exact physiolo

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Deng, Yi-Ting, та 鄧伊婷. "Arecoline-induced CCN2 expression in human buccal mucosal fibroblasts via TGF-β signaling pathway". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/13963642986315922516.

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博士<br>國立臺灣大學<br>臨床牙醫學研究所<br>100<br>Connective tissue growth factor (CCN2) is associated with the onset and progression of fibrosis in many human tissues. Areca nut (AN) chewing is the most important etiological factor in the pathogenesos of oral submucous fibrosis (OSF). We first immunohistochemically examined the expression of CCN2 protein in 20 cases of OSF and found positive CCN2 staining in fibroblasts and endothelial cells in all cases. Western blot analysis showed the arecoline, a main alkaloid found in AN, stimulated CCN2 synthesis in a dose- and time- dependent manner in buccal mucosal

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Wen-LunWang та 王文倫. "The roles of Disabled-2 and TGF-β signaling pathway in esophageal squamous cell carcinomas". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/qf38bb.

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博士<br>國立成功大學<br>臨床醫學研究所<br>103<br>Background: Patients with esophageal squamous cell carcinomas (ESCCs) have poor survival and frequently developed with synchronous head and neck squamous cell carcinomas (HNSCCs) . Disabled-2 (DAB2) is a crucial tumor suppressor for multiple signaling pathways (ERK, TGF-β etc.) and emerging evidences suggest TGF-β-induced regulatory T cells (Treg) enable tumor cells to escape immunosurveillance, resulting in tumor progression. We aimed to investigate the significance of DAB2 expression and Treg infiltration in ESCC and the field cancerization of esophagus at c

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Wang, Yen-Ting, та 王彥婷. "Genetic polymorphisms in the TGF-β signaling pathway associated with colorectal cancer in patients with Lynch syndrome". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/82bx83.

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碩士<br>臺北醫學大學<br>公共衛生學系暨研究所<br>104<br>Background: Lynch syndrome contributes to approximately 4% of all colorectal cancer (CRC) cases and is the most common hereditary colorectal cancer. It usually consisting of four mismatch repair (MMR) defects genes, MLH1, MSH2, MSH6 and PMS2, in particular, MLH1 and MSH2 gene mutation. TGF-β signaling pathway involves in many biological processes and disease, including cell proliferation, apoptosis, differentiation, migration and cancer. Many studies indicate that genetic polymorphisms on TGF-β signaling pathway may affect cancer risk. Objective: The aim of

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Aref, Donya. "Canonical TGF-β Pathway Activity is a Predictor of Medulloblastoma Survival and Delineates Putative Precursors in Cerebellar Development". Thesis, 2012. http://hdl.handle.net/1807/33325.

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Medulloblastoma (MB) is the most common pediatric malignant brain tumor. Little is known about aggressive forms of this disease. In order to identify pathways mediating aggressiveness in MB, we performed microarray experiments. Primary human MBs were compared to their patient matched recurrent or metastatic counterparts. Murine tumors from two MB mouse models that present with differing clinical severities were also evaluated. We identified the Transforming Growth Factor-beta (TGF-β) as a potential contributor to MB pathogenesis in both species. Smad3, a major downstream component of the TGF-β

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Malek, Daniela [Verfasser]. "Interaction of estrogen receptors and the TGF-β [TGF-beta] signal transduction pathway : impact on migration of human breast cancer cells / vorgelegt von Daniela Malek". 2007. http://d-nb.info/984089748/34.

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Šumová, Barbora. "Role nových profibrotických molekul v patogenezi systémové sklerodermie." Doctoral thesis, 2018. http://www.nusl.cz/ntk/nusl-373101.

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Systemic sclerosis (SSc) is immune-mediated fibrotic disease of unknown aetiology. Among the dominant pathogenic manifestations of SSc belong vascular changes, production of autoantibodies, activation of innate and adaptive immune responses and fibrotic processes. Transforming growth factor beta (TGF-β) has been identified as a central profibrotic factor stimulating fibroblasts to produce collagen. There are, however, a number of other mediators involved in the pathogenesis of SSc. Mutual activation and amplification of these molecules and their cascades may be a central mechanism of the SSc p

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Chen, Wei-Jen, та 陳為仁. "To investigate the regulation of Graptopetalun paraguayense in TGF-β pathway and lipogenesis in HCC via gene expression signature". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/rwzytc.

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碩士<br>國立陽明大學<br>生物藥學研究所<br>102<br>Hepatocellular carcinoma (HCC) is an aggressive tumor with a poor prognosis and most common cause of cancer deaths in the world. However, sorafenib is the only target therapy of HCC approved by the FDA and prolongs patient’s survival for 2-3 months. Therefore, it is urgent to identify new drug candidates for the treatment of HCC. To identify the therapeutic agents, we previously found that one of the herb medicine, GP and it partially purified fraction HH-F3 have anti-HCC and anti-fibrosis effects. However, the mechanism of HH-F3 was not clear yet. In this stu

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Vettori, Serena. "miR-145 is a key regulator of the TGF-β signaling pathway in systemic sclerosis and counteracts experimental fibrosis". Tesi di dottorato, 2013. http://www.fedoa.unina.it/9537/1/PhD_thesis_vettori.pdf.

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microRNAs (miRNAs) are key regulators of different basic cellular processes. A number of miRNAs have been found to be dysregulated in many disease settings, most notably cancers. The role of miRNAs in systemic sclerosis (SSc), as well as in other fibrotic disorders has been scarcely investigated. Here we analyzed miRNA expression profile in SSc and identified miR-145 as a deeply down-regulated miRNA in SSc dermal fibroblasts and skin, which plays a crucial role in the regulation of the TGF-beta pathway in vitro and in vivo.

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Heng, Nora [Verfasser]. "The effects of enamel matrix derivative (EMD) on the regulation of connective tissue growth factor (CTGF) expression in human osteoblastic cells via TGF-β [TGF-beta] pathway / von Nora Heng". 2007. http://d-nb.info/989222756/34.

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Khan, Imran. "Etiopathology Of Oral Submucous Fibrosis : Role Of Areca Nut Constituents And Transforming Growth Factor-β Signalling". Thesis, 2012. https://etd.iisc.ac.in/handle/2005/2477.

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Oral Submucous Fibrosis (OSF) is a chronic inflammatory disease resulting in progressive fibrosis of the oral tissues that can cause difficulty in chewing, swallowing, speaking, and mouth opening. Epidemiological studies have shown that OSF is a precancerous condition and 2-8% of the OSF patients develop squamous cell carcinoma. This disease affects 0.5% of the population in the Indian subcontinent and is now a growing public health issue in many parts of the world. Habit of chewing betel quid has been proposed as an important etiological factor in the development of this disease and is coline

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Khan, Imran. "Etiopathology Of Oral Submucous Fibrosis : Role Of Areca Nut Constituents And Transforming Growth Factor-β Signalling". Thesis, 2012. http://etd.iisc.ernet.in/handle/2005/2477.

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Oral Submucous Fibrosis (OSF) is a chronic inflammatory disease resulting in progressive fibrosis of the oral tissues that can cause difficulty in chewing, swallowing, speaking, and mouth opening. Epidemiological studies have shown that OSF is a precancerous condition and 2-8% of the OSF patients develop squamous cell carcinoma. This disease affects 0.5% of the population in the Indian subcontinent and is now a growing public health issue in many parts of the world. Habit of chewing betel quid has been proposed as an important etiological factor in the development of this disease and is coline

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Hsu, Yu-Wen, та 徐瑜彣. "The genetic polymorphism studies of ITPKC and TGF-β pathways in Kawasaki disease". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/38271768559773701640.

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碩士<br>高雄醫學大學<br>醫學遺傳學研究所<br>100<br>Kawasaki disease (KD) is an acute systemic vasculitis syndrome of an unknown etiology. KD occurs worldwide especially in Asia. In developed countries, KD is the leading cause of acquired heart disease in children. Previous studies identified several candidate regions by carring out Genome-wide association study for KD susceptibility. Functional SNPs in ITPKC (rs28493229) and CASP3 (rs72689236) had been confirmed the association with KD both in Japan and in Taiwan population indivisually. In non-excitable cells such as T cells and mast cells, the calcium influ

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Ranganathan, Prathibha. "Expression Profiling Of Genes Regulated By TGF-β : Role Of Multiple Signaling Pathways". Thesis, 2007. https://etd.iisc.ac.in/handle/2005/490.

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Transforming growth factor-β (TGF-β) is the proto-type member of a super family of secreted proteins comprised of several structurally related, but functionally divergent proteins like the BMP, activin, inhibin, mullerian inhibitory substance etc. TGF-β was originally identified as a secreted factor, which in the presence of EGF was capable of transforming normal rat kidney fibroblasts. Studies over the years have shown that this protein is multifunctional that influences several processes including development, immune function, epithelial cell growth and motility, wound healing etc. TGF-β pla

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Ranganathan, Prathibha. "Expression Profiling Of Genes Regulated By TGF-β : Role Of Multiple Signaling Pathways". Thesis, 2007. http://hdl.handle.net/2005/490.

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Transforming growth factor-β (TGF-β) is the proto-type member of a super family of secreted proteins comprised of several structurally related, but functionally divergent proteins like the BMP, activin, inhibin, mullerian inhibitory substance etc. TGF-β was originally identified as a secreted factor, which in the presence of EGF was capable of transforming normal rat kidney fibroblasts. Studies over the years have shown that this protein is multifunctional that influences several processes including development, immune function, epithelial cell growth and motility, wound healing etc. TGF-β pla

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Jheng, Kai-Yuan, та 鄭凱元. "Cyclosporin-A induced EMT through TGF-β and LOXL-2 pathways in gingival epithelial cells". Thesis, 2019. http://ndltd.ncl.edu.tw/handle/mk47k5.

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碩士<br>國立臺灣大學<br>臨床牙醫學研究所<br>107<br>Objectives: Cyclosporin A (CsA) is an immunosuppressive drug commonly used in organ transplant patients. Approximately 70% of the patients show gingival overgrowth (GO). Transforming growth factor (TGF-β) plays a major role in the GO. Previous studies have found that Cyclosporin A can induce epithelial-mesenchymal transition (EMT) via TGF-β signaling pathway, which then plays important roles in the pathogenesis of GO. Lysyl oxidase-like protein 2 (LOXL-2) : catalyzes the cross-linking of collagen and elastin to maintain the rigidity and stability of the ex

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Fonseca, Rodrigo Nunes da [Verfasser]. "The function of the TGF-β [TGF-beta] and toll signalling pathways in tribolium dorsoventral patterning / vorgelegt von Rodrigo Nunes da Fonseca". 2008. http://d-nb.info/99004498X/34.

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Melisi, Davide. "Smad- dependent and Smad- independent pathways in TGF-β signaling as therapeutic targets in pancreatic cancer". Tesi di dottorato, 2009. http://www.fedoa.unina.it/5020/1/Melisi_oncologia.pdf.

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Abstract:

Pancreatic cancer (PC) remains one of the most lethal and poorly understood human malignancies. Most PC patients present with inoperable disease, or develop metastases after surgery, and conventional therapies are usually ineffective in treating this disease. It is evident that novel therapies remain to be developed. Transforming Growth Factor β (TGF-β) is a family of dimeric olypeptide growth factors that initiate cell signaling by dimerizing the TGF-β type I (TβRI) and type II (TβRII) serine/threonine kinase receptors, which, in turn, propagate the signal by activating downstream Smad-depen

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Ho, Bing-Ying, та 何秉穎. "Alteration of TGF-β-mediated Signaling Pathways during Adriamycin(ADM) Resistant in NCI-H23 Non-small Cell Lung Cancer(NSCLC)". Thesis, 2003. http://ndltd.ncl.edu.tw/handle/08868561853374927826.

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碩士<br>臺北醫學大學<br>醫學研究所<br>91<br>Chemotherapy is a common therapy used for controlling metastatic tumor growth on cancer treatment today. However, it also often causes tumor cells resistant to the treatment. The displaying drug-resistance has been reported to be strongly associated with tumorgenesis. Therefore, this research is going to focus on how adriamycin-resistant cells prevent from TGFβ-mediated cell growth inhibition by altering its downstream signaling pathways in a non-small cell lung carcinoma cells (NSCLC), NCI-H23 cells. NCI-H23 Adriamycin —resistant (H23/ADR) cells are m

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Ma, Tian Hsiang, та 馬天祥. "The nucleolar size control in C. elegans: Roles of let-7/NCL-1/FIB-1 and TGF-β signaling pathways". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/wg8s6z.

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Ou, Shu-Ching, та 歐書晴. "TGF-β induced CTGF expression and epithelial-mesenchymal transition in human lung epithelial cells through ERK, ADAM17, RSK1, and C/EBPβ pathways". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/8934ch.

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