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Dissertations / Theses on the topic 'Th1/Th2 response'

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Published: 2 June 2025
Last updated: 31 July 2025

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1

Gold, Wendy Anne Clinical School St Vincent's Hospital Faculty of Medicine UNSW. "Characterisation of inflammatory markers and the Th1/Th2 response in localized scleroderma." Awarded by:University of New South Wales. Clinical School - St Vincent's Hospital, 2008. http://handle.unsw.edu.au/1959.4/41534.

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Scleroderma is a chronic autoimmune connective tissue disease of unknown etiology characterized by excessive fibrosis and is broadly divided into two clinical entities: localized scleroderma (LSc) and systemic sclerosis (SSc). SSc is a multi-system disease resulting in both skin and visceral organ fibrosis. The more benign disorder, LSc is for the most part self-limited with the disease pathology being confined to the skin and subcutaneous tissues. Proposed factors involved in the pathogenesis of these disorders include endothelial cell injury and dysfunction, immunological alterations and inf
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Kumar, Ramesh Kumar al Athi. "Association of angiogenesis with the host Th1/Th2 immune response in brain tumours." Thesis, University of Hull, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421208.

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3

Szymczak, Wendy A. "The Role Of Chemokines and Dendritic Cells In Regulation of IL-4 and Fungal Immunity." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1266607502.

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4

Ismail, Nahed. "Analysis of the decision criterion controlling the Th1/Th2 nature of a primary immune response." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ63879.pdf.

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5

Alabi, Andrew. "The association between psychosocial factors, angiogenesis & host Th1/Th2 immune response in patients with colorectal cancer." Thesis, University of Hull, 2013. http://hydra.hull.ac.uk/resources/hull:8006.

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Tumour angiogenesis is a critical step in the growth, metastatic spread and re-growth of colorectal cancer (CRC). VEGF-­A is one of the most studied angiogenic agents. A significant degree of the morbidity and mortality associated with colorectal cancer is related to the degree of tumour vascularity. As a consequence, considerable research has been undertaken in trying to understand the mechanisms involved in tumour associated angiogenesis and capillary permeability. A second important facet of cancer outcome is the host immune response against the tumour. The Th1/Th2 cytokine profile plays an
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Carvalho, Francilene Capel Tavares de. "Perfil de citocinas do padrão Th1, Th2, Th17 e o estado redox de indivíduos com leishmaniose visceral pré e pós tratamento." Botucatu, 2016. http://hdl.handle.net/11449/136436.

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Orientador: Sueli Aparecida Calvi<br>Coorientador: Lucilene Delazari dos Santos<br>Resumo: A leishmaniose visceral (LV) é causada pelos protozoários intracelulares obrigatórios pertencentes ao complexo Leishamania donovani (L.donovani). O sucesso na cura da LV depende principalmente do estado imunitário do hospedeiro em combinação com os efeitos das drogas leishmanicidas. Nesse sentido, a resistência do hospedeiro a leishmaniose está associada à produção de citocinas envolvidas na indução e efetuação de uma resposta do tipo Th1, como IL-12, IFN-γ e TNF-α. Essa resposta culmina na ativação de m
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Carvalho, Francilene Capel Tavares de [UNESP]. "Perfil de citocinas do padrão Th1, Th2, Th17 e o estado redox de indivíduos com leishmaniose visceral pré e pós tratamento." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/136436.

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Submitted by FRANCILENE CAPEL TAVARES DE CARVALHO null (francilene_capel@hotmail.com) on 2016-03-29T14:29:40Z No. of bitstreams: 1 DISSERTAÇÃO Francilene 2016.pdf: 1750315 bytes, checksum: 9561f4059507d40b1854398a6ede9620 (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-03-29T17:14:36Z (GMT) No. of bitstreams: 1 carvalho_fct_me_bot.pdf: 1750315 bytes, checksum: 9561f4059507d40b1854398a6ede9620 (MD5)<br>Made available in DSpace on 2016-03-29T17:14:36Z (GMT). No. of bitstreams: 1 carvalho_fct_me_bot.pdf: 1750315 bytes, checksum: 9561f40595
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Guimarães, João Agripino 1972. "Análise da polarização da resposta imunológica TH1 e TH2 em mulheres com infertilidade inexplicada e mulheres inférteis com endometriose = Polarization of TH1 and TH2 immune response analysis in women with unexplained infertility and infertity with endometriosis." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309005.

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Orientador: Egle Cristina Couto de Carvalho<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T11:06:18Z (GMT). No. of bitstreams: 1 Guimaraes_JoaoAgripino_M.pdf: 1627287 bytes, checksum: b5aedfb0c0a3b2d807c0d3324ae57317 (MD5) Previous issue date: 2012<br>Resumo: Contexto e objetivo: Alterações imunológicas podem estar associadas à infertilidade e endometriose. O objetivo deste estudo foi avaliar se, na infertilidade inexplicada e na infertilidade associada à endometriose, ocorre polarização da resposta imuno
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9

Stertman, Linda. "Starch Microparticles as an Oral Vaccine Adjuvant with Emphasis on the Differentiation of the Immune Response." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ-.bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4680.

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10

Santos, Bruna Rafaela Martins dos. "An?lise imuno-histoqu?mica de prote?nas relacionadas ?s respostas Th1, Th2 e Th17 na doen?a periodontal." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/18670.

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Made available in DSpace on 2015-03-03T15:38:42Z (GMT). No. of bitstreams: 1 BrunaRMS_TESE.pdf: 1789056 bytes, checksum: 3971348cc480ce2ec7b8b377a649483e (MD5) Previous issue date: 2011-02-17<br>Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior<br>Periodontal disease is an inflammatory condition of infectious nature characterized by destruction of protecting and supporting dental tissues. It happens as a response produced by the host when attacked by microorganisms. Several factors are involved in this process. Among them, cytokines are key regulatory molecules in this immune
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Brito, Rhubia Bethania Socorro Lemos de. "Modulação da resposta imunologica (Th2/Th1) em camundongos BALB/c previamente sensibilizados com ovalbumina e injetados com microesferas de PLGA encapsuladas com OVA." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313487.

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Orientador: Ricardo de Lima Zollner<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-07T22:53:38Z (GMT). No. of bitstreams: 1 Brito_RhubiaBethaniaSocorroLemosde_M.pdf: 1643193 bytes, checksum: 3883ffa4fdb888928db0d59dc9e0a674 (MD5) Previous issue date: 2006<br>Resumo: A imunoterapia é a estratégia empregada no tratamento das doenças alérgicas que, quando bem indicada, é considerada eficaz com redução dos sintomas. Apesar disso, uma das desvantagens é a possibilidade de surgirem reações sistêmicas adversas dura
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Coquerelle, Caroline. "Contrôle des réponses immunitaires de type Th1 par les lymphocytes T régulateurs naturels et induits." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210397.

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Depuis leur découverte en 1973 par Steinman et Cohn, le rôle des cellules dendritiques dans l’initiation des réponses immunitaires a largement été documenté. En effet, les cellules dendritiques constituent les cellules présentatrices d’antigènes professionnelles capables de détecter des molécules microbiennes et inflammatoires afin d’activer le système immunitaire. Outre leur implication dans l’induction des réponses immunes, de plus en plus d’études suggèrent que les cellules dendritiques interviennent dans le contrôle des réponses immunitaires via la sécrétion de cytokines anti-inflammatoire
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13

Daser, Angelika. "Untersuchungen zur Beteiligung zellulärer und genetischer Mechanismen bei Immunregulation und -modulation." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/14592.

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Durch Immunregulation und -modulation sorgt das Immunsystem dafür, daß von außen in den Organismus gelangende Agentien nicht zu dauerhaften Schäden führen. Wesentliche Funktionen des Immunsystems stützen sich dabei auf die zelluläre Immunität. Gerät dieses komplizierte Regelwerk aus dem Gleichgewicht, können schwere Erkrankungen autoimmuner oder atopischer Genese resultieren. Der erste Teil der Arbeit befaßt sich mit zwei Aspekten der zellulären Immunantwort. Allergische Immunantworten sind durch die Typ 2 T Zellantwort charakterisiert. Für die Induktion einer Typ 2 Antwort wird Int
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14

Labani, Motlagh Alireza. "Immune modulation in serous epithelial ovarian cancer : focus on the role of tumor-derived exosomes." Doctoral thesis, Umeå universitet, Institutionen för klinisk mikrobiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138264.

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Serous epithelial ovarian cancer (EOC) is a potent suppressor of the immune defense. Here, we studied interactions between EOC and the immune system that lead to escape from tumor immune surveillance. We explored: 1) tumor escape from cytotoxicity by exosome-mediated modulation of the NK-cell receptors NKG2D and DNAM-1; 2) cytokine mRNA profiles in the EOC microenvironment and peripheral blood and their role in the suppression of the anti-tumor immune responses; 3) expression of long non-coding (lnc) RNAs in EOC tumors and exosomes. We found that EOC-secreted exosomes carried MICA/B and ULBP1-
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15

Persson, Marie, Christina Ekerfelt, Barbara Jablonowska, et al. "Immunological status in patients undergoing in vitro fertilisation : responses to hormone treatment and relationship to outcome." Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-85640.

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We aimed to prospectively investigate the paternal antigen-induced cytokine secretion by peripheral blood mononuclear cells (PBMCs) in response to hormone treatment in women undergoing in vitro fertilisation (IVF) and to examine the predictive value of the cytokine secretion profile in the outcome of IVF treatment, in a pilot study. Twenty-five women were included and IVF treatment was successful for six and unsuccessful for 19 women. Blood samples were collected before IVF treatment, on four occasions during IVF and four weeks after embryo transfer. The numbers of Th1-, Th2- and Th17-associat
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16

Tigno-Aranjuez, Justine Daphne Tiglao. "Adjuvant Guided T cell Responses." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1244035297.

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17

Persson, Marie, Christina Ekerfelt, Jan Ernerudh та ін. "Reduced IFN-γ and IL-10 responses to paternal antigens during and after pregnancy in allergic women". Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-84900.

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Normal pregnancy and allergy are both characterized by a T helper (Th) 2 deviation. In the current study, we hypothesized that paternal antigen-induced cytokine responses during pregnancy would be deviated toward Th2 and an anti-inflammatory profile, and that the Th2 deviation would be more pronounced in allergic pregnant women. Blood samples were collected longitudinally on three occasions during pregnancy and two occasions post partum (pp). Of the 86 women initially included, 54 women had a normal pregnancy and completed the sampling procedures. Twelve women fulfilled the criteria for allerg
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18

Opiela, Shannon Jacqueline. "Neonatal T Cell Responses are Highly Plastic: I. Neonates Generate Robust T Cell Responses against Alloantigens II. Functional Capabilities of Neonatal RTE are more Diverse than Adult RTE." Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/139.

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Neonatal immune responses are typically deficient against a wide variety of antigens, including alloantigens, vaccine antigens, and infectious agents. These responses are characterized by Th2-skewed cytokine production, and deficient Th1 and cytotoxic responses. However, these deficient responses can be boosted to adult levels by the use of strong, Th1 promoting agents. This demonstrates that neonates are capable of developing mature immune responses under specific conditions. Using two different murine models, we have found that neonates develop robust Th and cytotoxic responses, which un
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19

Fairlie-Clarke, Karen Jane. "Significance of cross-reactive antibody responses and isotype bias in malaria-helminth co-infection." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5727.

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The socio-economic and geographical distribution of malaria overlaps with that of many parasitic helminths and in these areas co-infections are common. Co-infection with helminths can influence disease outcome causing either exacerbation or amelioration of malaria. Understanding the complex host-parasite interactions that lead to these different disease outcomes is important for the success of control programmes aimed at these parasites. The immune system has evolved diverse types of response (e.g. T-helper 1 (Th1) and T-helper 2 (Th2)) to efficiently combat infection with ‘microparasites’ and
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20

Marinho, Claudio Romero Farias. "Correlação entre a Carga Parasitária na Fase Aguda e a Intensidade da Patologia, Parasitismo e Ativação do Sistema Imune na Fase Crônica da Doença de Chagas Experimental." Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-11122007-114226/.

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0 objetivo deste trabalho foi definir se a carga parasitaria na fase aguda da doenga de Chagas experimental afeta a parasitemia, a patologia e a resposta imune na fase cr6nica. Para obtengelo de diferentes cargas parasitoirias na fase aguda, camundongos A/J foram infectados corn 103 OU 105 formas tripomastigotas de T. cruzi e analisados urn ano depois. Os animais cr6nicos infectados corn 105 formas tripomastigotas apresentaram maior nivel de parasitemia residual, maior intensidade de inflamagclo no coragtio e no moscuio esquel6tico e maior grau de ativa95o do sistema imune do que os animais
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21

Villanova, Laura. "Response surface optimization for high dimensional systems with multiple responses." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3421551.

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This thesis is about the optimization of physical systems (or processes) characterized by a high number of input variables (e.g., operations, machines, methods, people, and materials) and multiple responses (output characteristics). These systems are of interest because they are common scenarios in real-world studies and they present many challenges for practitioners in a wide range of applicative fields (e.g., science, engineering). The first objective of the study was to develop a model-based approach to support the practitioners in planning the experiments and optimizing the system response
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Ahyi, Ayélé-Nati. "The role of PU.1 and IRF4 interaction in the biology and function of T helper 2 cells." Connect to resource online, 2009. http://hdl.handle.net/1805/1882.

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Thesis (Ph.D.)--Indiana University, 2009.<br>Title from screen (viewed on August 26, 2009). Department of Microbiology and Immunology, Indiana University-Purdue University Indianapolis (IUPUI). Advisor(s): Mark Kaplan. Includes vita. Includes bibliographical references (leaves 107-125).
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Nguyen, Huong Thi Thanh. "Factors influencing health professionals' response to victims of domestic violence." Thesis, Queensland University of Technology, 2013. https://eprints.qut.edu.au/65558/1/Thi%20Thanh%20Huong_Nguyen_Thesis.pdf.

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This thesis examined factors influencing health professional's response to victims of domestic violence in Vietnam. As this is the first time that this type of research has been conducted in Vietnam, it was expected that the results would contribute significantly to local knowledge and should add to global perspectives. Since it is the first questionnaire about this topic to be developed in Vietnam, the psychometric property of the questionnaire was primarily established, resulting in the questionnaire being recommended to use for further study. By explaining the factors that affect the intent
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Hargreaves, Chantal. "The evolution of the autoantibody response in Graves' disease." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-evolution-of-the-autoantibody-response-in-graves-disease(b12a689c-e5d7-4478-b81a-40daa8b34a97).html.

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Graves’ disease (GD) is an antibody-mediated autoimmune disease caused by thyroid stimulating antibodies (TSAbs) activating the thyrotropin receptor (TSHR). Both genetic and environmental factors contribute to pathogenesis and one such factor is the infectious agent, Yersinia enterocolitica. Two high affinity TSAbs, (KSAbl, lgG2t>/K; KSAb2, IgGaa/K), developed from an experimental murine model of GD, share common germline Ig genes and thus are derived from the same precursor B cell clone which diversified through somatic hypermutation. The shared germline genes were expressed as recombinant (r
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Anthony, Robert McCullough. "Characterization and function of the inflammatory response to infection by a gastrointestinal nematode parasite : new insights into protective Th2 responses /." Download the dissertation in PDF, 2006. http://www.lrc.usuhs.mil/dissertations/pdf/Anthony2006.pdf.

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26

Silva, Flavia Marcia de Castro e. "Influência da obesidade induzida por dieta hiperlipídica sobre a resposta imune em modelo experimental de alergia pulmonar." Universidade Federal de Juiz de Fora, 2015. https://repositorio.ufjf.br/jspui/handle/ufjf/1360.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2016-05-03T11:38:10Z No. of bitstreams: 1 flaviamarciadecastroesilva.pdf: 2659537 bytes, checksum: 1c8331ace53624c1553f76ae25681622 (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2016-06-03T15:37:23Z (GMT) No. of bitstreams: 1 flaviamarciadecastroesilva.pdf: 2659537 bytes, checksum: 1c8331ace53624c1553f76ae25681622 (MD5)<br>Made available in DSpace on 2016-06-03T15:37:23Z (GMT). No. of bitstreams: 1 flaviamarciadecastroesilva.pdf: 2659537 bytes, checksum: 1c8331ace53624c1553f76ae25681622 (M
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Wilding, Timothy. "Using the auditory steady-state response to diagnose dead regions in the cochlea." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/using-the-auditory-steadystate-response-to-diagnose-dead-regions-in-the-cochlea(d25d8561-4ec4-4d37-9734-10ac9015d251).html.

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The current behavioural dead region (DR) diagnosis methods such as psychophysical tuning curves and the threshold-equalising noise test require extensive subject co-operation. These present methods cannot be applied to infants. The work presented in the thesis aimed to develop a fast objective DR diagnosis method that could be applied to sleeping hearing-impaired infants. A novel fast objective electrophysiological method of recording response amplitude curves (RACs) which could enable objective DR diagnosis was developed.RACs were derived by recording auditory steady-state response amplitudes
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MacKinnon, Kathryn Michelle. "Differential gene expression and immune regulatory mechanisms in parasite-resistant hair and susceptible wool sheep infected with the parasitic nematode, Haemonchus contortus." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/28467.

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Among sheep producers, the parasitic nematode Haemonchus contortus is a major animal health concern. Caribbean hair sheep are more resistant than conventional wool breeds to this blood-feeding, abomasal parasite. Our objective was to determine differences in the immune response associated with parasite-resistant hair and susceptible wool lambs infected with 10,000 H. contortus and in uninfected controls. Animals were sacrificed and abomasum and lymph node tissues were collected at 3 or 27 days post-infection (PI), and for controls on day 17, 27, or 38 relative to d 0 of infected animals. B
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Oun, Rabiaa R. Salah. "The Rad9.M50 variant of the DNA damage checkpoint protein Rad9 regulates the MAP kinase pathway in the response to heat stress." Thesis, Bangor University, 2016. https://research.bangor.ac.uk/portal/en/theses/the-rad9m50-variant-of-the-dna-damage-checkpoint-protein-rad9-regulates-the-map-kinase-pathway-in-the-response-to-heat-stress(507c63ee-2f27-4f3d-a39b-e7dba7201f95).html.

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Environmental stress activates the MAP kinase pathway to regulate transcription and cell division. In this pathway, a MAP kinase kinase kinases (MAPKKK) activates the MAP kinase kinase (MAPKK) which in turn phosphorylates the MAP kinase (MAPK) simultaneously at a serine or threonine residue and a tyrosine residue in close vicinity. In the fission yeast Schizosaccharomyces pombe, the dual specific MAPKK Wis1 phosphorylates the MAPK Sty1/Spc1 at threonine 171 and tyrosine 173. Active Sty1 phosphorylates and activates the transcription factor Atf1. Sty1 is closely related to Hog1 in the budding y
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Buske-Kirschbaum, Angelika. "Cortisol Responses to Stress in Allergic Children: Interaction with the Immune Response." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135731.

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Allergic manifestations are increasingly common in infants and children. Accumulating evidence suggests that the ‘epidemic’ increase of childhood allergy may be associated with environmental factors such as stress. Although the impact of stress on the manifestation and exacerbation of allergy has been demonstrated, the underlying mechanisms of stress-induced exacerbation are still obscure. A growing number of studies have suggested an altered hypothalamus-pituitary-adrenal (HPA) axis function to stress in allergic children. It is speculated that a dysfunctional HPA axis in response to stress m
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Buske-Kirschbaum, Angelika. "Cortisol Responses to Stress in Allergic Children: Interaction with the Immune Response." Karger, 2009. https://tud.qucosa.de/id/qucosa%3A27671.

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Allergic manifestations are increasingly common in infants and children. Accumulating evidence suggests that the ‘epidemic’ increase of childhood allergy may be associated with environmental factors such as stress. Although the impact of stress on the manifestation and exacerbation of allergy has been demonstrated, the underlying mechanisms of stress-induced exacerbation are still obscure. A growing number of studies have suggested an altered hypothalamus-pituitary-adrenal (HPA) axis function to stress in allergic children. It is speculated that a dysfunctional HPA axis in response to stress m
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32

Linn, Rachel E. "Adaptation as Reader-Response to The Sound and the Fury." Ohio University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1213116585.

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33

Xiao, Yanping. "APRIL (TNFSF13) in Th1, Th2 and Th17 Responses." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/335.

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The T cell function of a proliferation inducing ligand (APRIL or TNFSF13) remains unclear. By comparing APRIL-/- mice with wild type (WT) mice, we have investigated the roles of APRIL in Th1, Th2 and Th17 responses. With regard to APRIL in Th1 responses, cultured APRIL-/- CD4+ T cells showed increased IFN-gamma production under non-polarizing, but not under Th1 polarizing, conditions. No difference in antigen-specific IgG2a levels existed between APRIL-/- and WT mice immunized with ovalbumin (OVA) and complete Freund's adjuvant (CFA) which induces Th1 polarization. Our data indicate that APRI
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Mackenzie, Rebecca. "Investigating the heat shock response of the yeast proteome via quantitative proteomics." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/investigating-the-heat-shock-response-of-the-yeast-proteome-via-quantitative-proteomics(ea5b80a1-6a4a-4207-847e-aefd3e6e4832).html.

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Proteostasis, the regulation of protein abundance and function in cellular systems, underpins the ability of organisms to deal with environmental challenge such as heat shock stress. In this thesis, a quantitative study of this process at the molecular level has been undertaken using the model eukaryote S. cerevisiae to characterise the protein level response to heat shock. Although well studied, much of the previous work has focussed on changes at the mRNA levels or relative changes in protein expression. To address this, an absolute quantification strategy was developed utilising the QconCAT
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Otto, Sarah. "The role of circadian rhythm in the immune response to Trichuris muris." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-circadian-rhythm-in-the-immune-response-to-trichuris-muris(cc0b22e0-4fd6-4bf3-8741-f773b9e1783e).html.

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Circadian rhythms have been implicated in severity and outcome of infection and disease. Commonly, LPS and bacterial infection have been used to identify the mechanisms behind the difference in immune responses depending on the time of day of the challenge. In this thesis, the colon dwelling nematode parasite Trichuris muris, which elicits a Th2 immune response in resistant mice, was used to identify if circadian rhythms influence infection outcome 3 weeks post infection. C57BL/6 mice infected with 200 eggs of T. muris at ZT0 (7am, lights on) expelled the parasite more efficiently than mice in
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Hornung, Benjamin. "Anal Acoustic Reflectometry in the evaluation of the anal sphincter and the response to treatment of faecal incontinence." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/anal-acoustic-reflectometry-in-the-evaluation-of-the-anal-sphincter-and-the-response-to-treatment-of-faecal-incontinence(723292f1-672f-4672-b4ef-89865db1fd71).html.

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Anal Acoustic Reflectometry (AAR) is a novel technique providing a dynamic physiological assessment of anal sphincter function. In AAR wide band sound waves are transmitted into a thin polyurethane bag placed within the anal canal. The reflection of these sound waves allows calculation of the cross-sectional area of the anal canal. The bag is slowly inflated and deflated, during which simultaneous cross-sectional area and pressure measurements are taken along the entire length of the anal canal. This allows Opening Pressure, Opening Elastance, Closing Pressure, Closing Elastance and Hysteresis
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Field, Douglas Preston. "The Physiological Control of Verbal Behavior." Thesis, University of North Texas, 1992. https://digital.library.unt.edu/ark:/67531/metadc500887/.

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The current study sought to investigate whether physiological responses, such as the electrodermographic response (EDG) and/or the frontalis muscle electrical potential (EMG) could be developed as a source of control over verbal responses. Discrimination training procedures using points exchangeable for money were employed to condition verbal responses occasioned by minute interoceptive events with 2 adult human subjects. Specific verbal responses were reinforced in the presence of changes in EDG with Sl and EDG and EMG with S2. Stimulus control over differentiated verbal responses was demonst
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38

Bai, Rongning. "Brecht and China : a mutual response." Thesis, University of Warwick, 1996. http://wrap.warwick.ac.uk/4493/.

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This thesis deals with the cross-cultural relations between Brecht and China through an analysis of how Brecht responded to the traditional Chinese theatre and how his drama was received in turn by modern Chinese theatre. It attempts to examine the respective socio-cultural or political contexts wherein such kind of crosscultural contacts were needed, and the consequent aesthetic-theatrical as well as socio-cultural or political changes brought about by these contacts that have produced two distinctively independent yet related forms of theatre. It is argued that Brecht's search for a theatre
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Lamey, Emeel S. "The Idea of ‘Holy Islamic Empire’ as a Catalyst to Muslims’ Response to the Second Crusade." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etd/2359.

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The oral traditions in the Islamic world presented only the moral benefits of Jihad. Yet, the fact is that, though the moral benefits continued to exist before and after the First Crusade, though the interest seemed to have been present and the necessary intellectual theories continued on, Muslims did not advance the practical Jihad. Nonetheless, the disastrous Second Crusade struck a powerful chord among Muslims. It forced Muslims to battle for their very survival, and to do so they would have to adapt, but equally they could only survive by drawing on their imperial inheritance built up over
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Mejia-Trejo, Adan. "Upwelling off the coast of Oman during the S.W. monsoon." Thesis, Bangor University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304305.

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De, Simoni Sara. "The contribution of the brain response to ketamine to understanding the glutamatergic system and its role in human cognition." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-contribution-of-the-brain-response-to-ketamine-to-understanding-the-glutamatergic-system-and-its-role-in-human-cognition(2bae6bd8-8cda-49bd-b817-87a4bbdb9e28).html.

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A high degree of interest continues in studying the central effects of ketamine, an NMDA receptor (NMDAR) antagonist, due to its potential relevance to schizophrenia, antidepressant efficacy and analgesia. This thesis investigates the brain response to ketamine to (1) determine whether it is a valuable pharmacological tool to investigate glutamatergic dysfunction and (2) further our knowledge on the role of the glutamatergic system in human cognition. The administration of low-dose ketamine to healthy volunteers was combined with arterial spin labelling (ASL) and blood oxygen level dependent (
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42

Terzic, Marilyn. "Understanding television: the art and science of aesthetic response." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104508.

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This dissertation examines the processes of perception and cognition and demonstrates their application to the creation of aesthetically and artistically significant television content. By reexamining past understandings and assumptions, the ways in which artists and media producers have manipulated the information search and processing faculties of their audiences, and thus guided the meanings they ascribed to still and moving images, are explored. To reflect the multidisciplinary nature of television aesthetics, this research is not limited to a particular academic discipline. Instead, it dr
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Sampaio, Mariana Neiva. "The role of personality in fish response to Carbamazepine: from biochemical responses to learning." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22022.

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Mestrado em Biologia Molecular e Celular<br>A personalidade animal está ligada aos processos fisiológicos e bioquímicos do organismo. É definida como um conjunto individual de padrões comportamentais que se mantêm ao longo de um determinado período de vida. Estudos recentes mostraram a capacidade de muitos compostos, incluindo fármacos, interferirem no comportamento e em traços da personalidade. No entanto, o conhecimento sobre este fenómeno é ainda limitado. Sabendo-se que os fármacos podem interferir na personalidade, coloca-se a questão: qual será o papel da personalidade no efeito dos fárm
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Hurley, Elisabeth. "Effects of early light environment on the photic response of the circadian system." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/effects-of-early-light-environment-on-the-photic-response-of-the-circadian-system(6b32d591-5394-4f1e-a422-7458eb740c2c).html.

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Early light environment has been shown to alter locomotor activity behaviour in adult rats and mice when exposed to constant light (LL), constant darkness (DD) or 12:12 hour light-dark cycles (LD). In particular, exposure to LL during lactation results in an increased ability to cope with exposure to LL as adults, implying that the ability to interpret light information is altered depending on early light environment. Therefore, the aim of this project was to explore how early light environment affects the photic response of the circadian system. The retina forms the first component of the pho
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Chidgey, James. "The role of reactive oxygen species in the endothelium derived hyperpolarising factor response." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-reactive-oxygen-species-in-the-endothelium-derived-hyperpolarising-factor-response(fbc0bac4-9a82-4156-bf12-64e705df631f).html.

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EDHF is the endothelium-dependent but nitric oxide (NO) and prostacyclin (PGI2) -independent vasodilatation pathway that is the dominant relaxation mechanism in the microcirculation, and has been shown to require IKCa and SKCa channel activation and also functional myoendothelial gap junctions. Reactive oxygen species (ROS) have been implicated in the response, but their precise role remains uncertain. To investigate this, the cremaster muscle circulation of freshly killed rats was perfused with a Krebs buffer solution containing albumin (1 g.l-1) and either FITC-albumin (2 g.l-1) to measure c
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Qvarfordt, Lisa. "Communicating and engaging with crisis-affected people in humanitarian responses: a case study of the Red Cross Ebola response in Liberia." Thesis, Malmö högskola, Fakulteten för kultur och samhälle (KS), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-23604.

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Changing the approach to communication and engagement with the local people in Liberia during the Ebola response turned out to be a key strategy in the Red Cross’ work. The Liberian Red Cross’ communication with the crisis-affected people changed significantly during the fight against the Ebola virus, from top-down information to a more dialogical communication approach. The Ebola epidemic in West Africa has caused more than 11 000 deaths since the outbreak in March 2014. The task of defeating the virus seemed overwhelming at times, but the outbreak finally stopped and all the three worst hit
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Ujor, Victor Chinomso. "The physiological response of the white-rot fungus, Schizophyllum commune to Trichoderma viride, during interspecific mycelial combat." Thesis, University of Westminster, 2010. https://westminsterresearch.westminster.ac.uk/item/9084x/the-physiological-response-of-the-white-rot-fungus-schizophyllum-commune-to-trichoderma-viride-during-interspecific-mycelial-combat.

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Fungal species compete for space and nutrients in organic matter, resulting in strong morphological and biochemical reactions in the interacting mycelia. Interspecific mycelial interactions have attracted extensive studies because of their potential applications in biological control, bio-pulping, screening for novel bioactive metabolites and enhancement of extracellular enzyme production. Studies of interspecific mycelial combat have also contributed to the understanding of the structure and development of fungal communities. Although the behaviour of interacting mycelia has been understood,
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Sibanyoni, Bhekinkosi S. "A pastoral care response to the false philosophy that poverty breeds deep spirituality." Pretoria : [s.n.], 2009. http://upetd.up.ac.za/thesis/available/etd-04082009-205125/.

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Henslin, Kayla B. "Rapidity of response to hypoxic conditions during exercise /." Connect to online version, 2009. http://minds.wisconsin.edu/handle/1793/45116.

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Newton, Mark K. "The initial perception of humidity." Thesis, University of Portsmouth, 2011. https://researchportal.port.ac.uk/portal/en/theses/the-initial-perception-of-humidity(5c072ca2-6291-450a-a7ac-32c9d6ec1cbc).html.

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