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Dissertations / Theses on the topic 'The polymorphism of genes'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Bergman, Ingrid-Maria. "Polymorphism in pattern recognition receptor genes in pigs." Doctoral thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-116.

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The mammalian immune defense consists of two systems, which are interconnected and co-operate to provide host defense. The innate immune system is always active and detects and responds to non-self without delay. The adaptive immune system has a lag phase, but is more specific and has got a memory. The innate immune system relies on pattern recognition receptors (PRRs) to detect molecular patterns signaling microbial presence. This thesis focuses on a centrally placed family of PRRs, namely the Toll-like receptors (TLRs), and on mannan-binding lectin (MBL), a PRR which initiates the lectin act

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2

Risch, Angela. "Polymorphism in arylamine N-acetyltransferase in bladder cancer." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297022.

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3

O'Neill, Ann Marie Ewald Sandra J. "Polymorphism in chicken immune response genes and resistance to disease." Auburn, Ala., 2007. http://repo.lib.auburn.edu/2007%20Fall%20Dissertations/O'Neill_Ann_48.pdf.

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4

Vaughan, Tanya, and n/a. "Identifying Genes Influencing Bone Mineral Density." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040430.161453.

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Bone mineral density (BMD) is a reflection of the action of osteoblasts compared to osteoclasts. An imbalance in the activity of osteoblasts or osteoclasts, results in bone disease such as osteoporosis caused by overactive osteoclasts. BMD is influenced by genetic and environmental factors as demonstrated through twin studies, association studies and linkage analysis (Ralston, 1999). Several polymorphisms involved in the determination of BMD have been identified, with Vitamin D receptor and Collagen Type 1 showing reproducible associations. To identify genes influencing BMD two distinct st

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5

Vaughan, Tanya. "Identifying Genes Influencing Bone Mineral Density." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/366470.

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In summary, this study investigated the role of novel polymorphisms and rare variants of the RUNX2 gene in influencing BMD, fracture and markers of bone turnover. Two common polymorphisms were identified within the polyA repeat: an 18 base pair deletion and a synonymous alanine codon polymorphism with alleles, A and G. The A allele was associated with increased BMD and was protective against a common form of osteoporotic fracture within a Geelong population. To verify these findings the RUNX2 alleles were genotyped in 992 women from a Scottish cohort. The magnitude and the direction of the eff

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6

Baker, Sarah Elizabeth. "Epithelial Sodium Channel Polymorphism Influences Lung Function." Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/306770.

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Epithelial sodium channels (ENaC) are located throughout the epithelial lining of the respiratory tract and play a crucial role in ion and fluid homeostasis of the lungs. Increasing ENaC activity through stimulation of β₂-adrenergic receptors has been shown to increase sodium and fluid reabsorption from the airspace to the interstitial space. In cystic fibrosis lung disease there is a hyperabsorption of sodium through ENaC which results in dehydration of the airway surface liquid. Previous work has identified a common functional genetic variant of SCNN1A, the gene encoding the ENaC alpha-subun

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7

Hulin-Curtis, Sarah Louise. "Genetic polymorphism within osteo-metabolic related genes and association with osteoarthritis." Thesis, University of Bristol, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414193.

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8

Swarbrick, Michael. "Candidate genes for obesity and related phenotypes." University of Western Australia. Dept. of Pathology, 2002. http://theses.library.uwa.edu.au/adt-WU2004.0033.

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The current epidemic of obesity poses a substantial threat to public health worldwide. Obesity is associated with many deleterious health conditions, including type 2 diabetes, hypertension, dyslipidaemia, respiratory conditions, arthritis, and some forms of cancer. Moreover, the rising prevalence of obesity has been accompanied by a substantial increase in the cost of treating these conditions. Obesity results from a complex interaction between behavioural, environmental, and genetic factors. While the recent increase in the prevalence of obesity is largely due to behavioural factors (for exa

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9

Moheghi, Nasrin. "IRAMS database generation and investigation of HLA genes, KIR genes, S1PR1 gene polymorphism, and IL-17 levels in Iranian Multiple Sclerosis patients." Thesis, St George's, University of London, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.754071.

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Introduction Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS). Human Major Histocompatibility complex (HLA) class I and II genes are associated with MS pathogenesis. Natural killer cell receptors (KIRs) bind to different MHC class I molecules activating NK cells to produce immune-regulatory cytokines. Sphingosine 1-phosphate receptor 1 (S1PR1) polymorphism and increasing IL-17 levels in blood of MS patients associate with nonresponding to fingolimod treatment. Aim: To investigate HLA class I and II alleles, MOG (V142L) variant, KIR receptor genes,

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10

Koido, Kati. "Single-nucleotide polymorphism profiling of 22 candidate genes in mood and anxiety disorders /." Online version, 2005. http://dspace.utlib.ee/dspace/bitstream/10062/889/5/koido.pdf.

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11

Wegner, Karl Mathias. "Major histocompatibility genes, polymorphism and balancing selection the case of parasites and sticklebacks /." [S.l.] : [s.n.], 2004. http://e-diss.uni-kiel.de/diss_1206/d1206.pdf.

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12

Wiedmer, Stefanie, Alexander Erdbeer, Beate Volke, et al. "Identification and analysis of Eimeria nieschulzi gametocyte genes reveal splicing events of gam genes and conserved motifs in the wall-forming proteins within the genus Eimeria (Coccidia, Apicomplexa)." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2018. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-231860.

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The genus Eimeria (Apicomplexa, Coccidia) provides a wide range of different species with different hosts to study common and variable features within the genus and its species. A common characteristic of all known Eimeria species is the oocyst, the infectious stage where its life cycle starts and ends. In our study, we utilized Eimeria nieschulzi as a model organism. This rat-specific parasite has complex oocyst morphology and can be transfected and even cultivated in vitro up to the oocyst stage. We wanted to elucidate how the known oocyst wall-forming proteins are preserved in this rodent E

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13

Zetouni, Larissa [UNESP]. "Polimorfismo nos genes da leptina e do receptor de melatonina em búfalas (Bubalus bubalis)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/92580.

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Made available in DSpace on 2014-06-11T19:26:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-04-25Bitstream added on 2014-06-13T20:54:06Z : No. of bitstreams: 1 zetouni_l_me_jabo.pdf: 337751 bytes, checksum: b21af7c1ec9b43b60d9345d076668d73 (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>O gene responsável pela codificação do hormônio leptina tem sido associado à produção de leite, e diversos polimorfismos encontrados nesse gene foram associados a características produtivas em bovinos. O objetivo do presente estudo foi a identificação do polimorfismo

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14

Wiedmer, Stefanie, Alexander Erdbeer, Beate Volke, et al. "Identification and analysis of Eimeria nieschulzi gametocyte genes reveal splicing events of gam genes and conserved motifs in the wall-forming proteins within the genus Eimeria (Coccidia, Apicomplexa)." EDP Sciences, 2017. https://tud.qucosa.de/id/qucosa%3A30707.

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The genus Eimeria (Apicomplexa, Coccidia) provides a wide range of different species with different hosts to study common and variable features within the genus and its species. A common characteristic of all known Eimeria species is the oocyst, the infectious stage where its life cycle starts and ends. In our study, we utilized Eimeria nieschulzi as a model organism. This rat-specific parasite has complex oocyst morphology and can be transfected and even cultivated in vitro up to the oocyst stage. We wanted to elucidate how the known oocyst wall-forming proteins are preserved in this rodent E

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15

Ramdayal, Kavisha. "Incidence and Regulatory Implications of Single Nucleotide Polymorphisms among Established Ovarian Cancer Genes." Thesis, Online access, 2009. http://etd.uwc.ac.za/usrfiles/modules/etd/docs/etd_gen8Srv25Nme4_5111_1277754725.pdf.

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16

Shook, Kerida Stephanie [Verfasser]. "Polymorphism identification and characterisation within candidate genes for scrapie susceptibility in sheep / Kerida Stephanie Shook." Gießen : Universitätsbibliothek, 2014. http://d-nb.info/1068535539/34.

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17

Silva, Erica Furquim Soledade Neves. "Polimorfismos dos genes GSTM1 e GSTT1, do sistema da Glutationa S-Transferase, e T6235C e A4889G do gene CYP1A1, do sistema do Citocromo P450, na susceptibilidade ao carcinoma de celulas escamosas de cabeça e pescoço." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290505.

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Orientador: Carmen Silvia Passos Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-10T01:04:22Z (GMT). No. of bitstreams: 1 Silva_EricaFurquimSoledadeNeves_M.pdf: 1247474 bytes, checksum: fb164930ca8036640d7d8a9b9f56bca8 (MD5) Previous issue date: 2007<br>Resumo: As glutationa S-transferases (GSTs) são enzimas detoxificantes que atuam no mecanismo de proteção contra a carcinogênese. Os genes GSTM1 e o GSTT1 são polimórficos em humanos e estão deletados de forma homozigótica em 40-50% e 15-25% dos

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18

Lyrenäs, Louise. "Molecular genetic studies of oxidative stress related genes /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-475-9.

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19

Feuk, Lars. "SNP based strategies to study candidate genes for Alzheimer's disease /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-334-1.

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20

Shavorskaya, Oksana. "Identification of genes affecting flowering time variation in Brassica species /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/a453.pdf.

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21

Micoogullari, Yagmur. "Polymorphisms Of Epoxide Hydrolase Genes And Ischemic Stroke Risk In Turkish Population." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613497/index.pdf.

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Stroke is characterized with loss of one or more functions of the body resulted by inadequate blood supply to the brain. Most of the cases result from a blood clot forms on an atherosclerotic plaque in the brain which is called as ischemic stroke. Structure of the arteries and vascular tone are listed in major determinants in the development of the disorder. Soluble epoxide hydrolase (sEH, EPHX2) catalyzes conversion of epoxyeicosatrienoic acids to inactive diol metabolites. EETs are potent vasodilators that participate in the regulation of vascular tone and cerebral blood flow. Microsomal epo

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22

Shao, Jing. "Association of polymorphisms in the glutamate cysteine ligase catalytic subunit gene and glutathione-S-transferase genes with fibrotic lung diseases /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/8452.

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23

Lima, Luana Nepomuceno Gondim Costa. "Estudo do polimorfismo dos genes das citocinas TNFα, IFNγ, TGFβ, IL-6, E IL-10 em hansenÃase." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=3734.

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As citocinas desempenham um papel importante na resposta imune do hospedeiro contra o M. leprae. Polimorfismos de genes de citocinas tÃm sido implicados como um fator do hospedeiro influenciando a susceptibilidade para doenÃas infecciosas. O objetivo deste estudo foi verificar a relaÃÃo entre a hansenÃase e os polimorfismos dos genes TNFα (fator de necrose tumoral-α) -308 G→A; IFNγ (interferon-γ) +874 T→A; IL-6 (interleucina-6) -174 G→C; IL-10 -1082 A→T, -819 C→T, -592 A→C e TGFβ (fator de crescmento tumoral-β) cÃdon 10 e cÃdon

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24

Zetouni, Larissa. "Polimorfismo nos genes da leptina e do receptor de melatonina em búfalas (Bubalus bubalis) /." Jaboticabal : [s.n.], 2012. http://hdl.handle.net/11449/92580.

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Orientador: Humberto Tonhati<br>Coorientador: Marcelo Cervini<br>Banca: Maria Elisabete Jorge Amaral<br>Banca: Joslaine Noely dos Santos Gonçalves Cyrillo<br>Resumo: O gene responsável pela codificação do hormônio leptina tem sido associado à produção de leite, e diversos polimorfismos encontrados nesse gene foram associados a características produtivas em bovinos. O objetivo do presente estudo foi a identificação do polimorfismo LEP-1620 (A/G) no gene bubalino da leptina e suas possíveis associações com as produções de leite, gordura, proteína e porcentagens de gordura e proteína. Foram colet

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25

Davids, Muneera. "Single nucleotide polymorphism association studies of ABCA13 and ABHD11 genes and the bioinformatics analysis of the autism candidate genes localized on chromosome 7." University of the Western Cape, 2016. http://hdl.handle.net/11394/4977.

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Magister Scientiae - MSc<br>Autism, Aspergers Syndrome and Pervasive Developmental Delay-Not Otherwise Specified (PDD-NOS), among others, fall under an umbrella of disorders known as Autism Spectrum Disorder. Twin studies show that autism is a highly heritable disorder. More than 100 genes have been implicated in the aetiology of autism, each of which is involved in numerous biological processes and a variety of molecular interactions. William-Beuren syndrome is a multisystem developmental disorder caused by the deletion of contiguous genes at the 7q11.23 position. The aims of this study were

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26

Carvalho, Filipa Abreu Gomes de. "Mucin genes (MUC1 and MUC6) polymorphism and gastric carcinoma risk = Polimorfismo de genes das mucinas (MUC1 e MUC6) e risco de carcinoma gástrico." Doctoral thesis, Universidade do Porto. Reitoria, 1999. http://hdl.handle.net/10216/10268.

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Dissertação de Doutoramento em Biologia Humana apresentada à Faculdade de Medicina da Universidade do Porto<br>Neste trabalho procurou esclarecer-se a contribuição de factores de risco do hospedeiro para o desenvolvimento do carcinoma gástrico, no complexo contexto das interacções gene/ambiente.I Polimorfismo dos genes MUC1 e MUC6 e risco de carcinoma gástricoUtilizando a técnica de Southern blotting, realizaram-se estudos de caso-controlo para avaliar o polimorfismo dos genes MUC1 e MUC6, em dadores de sangue e em doentes com carcinoma gástrico.Verificou-se que a distribuição alélica e geno

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Carvalho, Filipa Abreu Gomes de. "Mucin genes (MUC1 and MUC6) polymorphism and gastric carcinoma risk = Polimorfismo de genes das mucinas (MUC1 e MUC6) e risco de carcinoma gástrico." Tese, Universidade do Porto. Reitoria, 1999. http://hdl.handle.net/10216/10268.

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Dissertação de Doutoramento em Biologia Humana apresentada à Faculdade de Medicina da Universidade do Porto<br>Neste trabalho procurou esclarecer-se a contribuição de factores de risco do hospedeiro para o desenvolvimento do carcinoma gástrico, no complexo contexto das interacções gene/ambiente.I Polimorfismo dos genes MUC1 e MUC6 e risco de carcinoma gástricoUtilizando a técnica de Southern blotting, realizaram-se estudos de caso-controlo para avaliar o polimorfismo dos genes MUC1 e MUC6, em dadores de sangue e em doentes com carcinoma gástrico.Verificou-se que a distribuição alélica e geno

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28

Chan, Yuen Man. "Functional analysis of single nucleotide polymorphisms in the proximal promoter regions of the multidrug transporter genes MRP1/ABCC1 and MRP4/ABCC4." Thesis, Kingston, Ont. : [s.n.], 2007. http://hdl.handle.net/1974/730.

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29

Haataja, R. (Ritva). "The role of surfactant protein A and B genes in heritable susceptibility to neonatal respiratory distress syndrome." Doctoral thesis, University of Oulu, 2001. http://urn.fi/urn:isbn:9514265254.

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Abstract Respiratory distress syndrome (RDS) is a disease characterized by neonatal respiratory failure. It is principally caused by a deficiency of pulmonary surfactant, which is a lipoprotein mixture essential for reducing surface tension at the air-liquid interface of the alveolus. Prematurity is the major risk factor predisposing to RDS. Several pieces of evidence suggest the role of genetic factors in the susceptibility to this multifactorial disease. The present study was performed to determine whether polymorphisms of the surfactant protein SP-A1, SP-A2 and SP-B genes associate

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30

Hinuy, Hamilton Massayuki. "\"Avaliação de regiões hipervariáveis de genes que predispõem à obesidade\"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-31082006-215706/.

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As variantes genéticas LEP G-2548A, LEP 3\'HVR, D1S200 (LEPR),D18S858 (MC4R) e D2S1788 (POMC)foram avaliadas em 100 indivíduos obesos (GE) e 110 não-obesos (GC) brancos. A genotipagem desses indivíduos foi realizada por PCR e RFLP. As freqüências dos alelos LEP -2548G e LEP 3\'HVR-Classe I no grupo GE foram maiores que no GC P<0,05). O haplótipo LEP G/I foi mais freqüente no grupo GE (P=0,018) e nos indivíduos com obesidade central (P=0,047). As freqüências dos alelos 41/42 da D18S858 e do alelo 17 da D1S200 foram maiores (P<0,05) no grupo GE. Os indivíduos com alelos LEP 3\'HVR-Classe I, 41/4

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31

Ota, Vanessa Kiyomi Arashiro [UNIFESP]. "Esquizofrenia e síndrome da deleção 22q11.2: Caracterização de genes relevantes." Universidade Federal de São Paulo (UNIFESP), 2011. http://repositorio.unifesp.br/handle/11600/9477.

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Made available in DSpace on 2015-07-22T20:50:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-22<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Introdução: A esquizofrenia é o transtorno mental mais grave e incapacitante entre os distúrbios psiquiátricos. Ela é uma doença complexa e com fenótipo heterogêneo. Dentre os fatores genéticos que parecem ter um papel na etiologia da esquizofrenia está a deleção 22q11.2. Obje

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32

Atan, Deniz. "Cytokine gene polymorphism in non-infectious uveitis." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492470.

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Non-infectious uveitis is a blinding intraocular inflammatory disorder with an autoimmune pathogenesis. Like other autoimmune diseases, uveitis has multifactorial and polygenic aetiology. The results of this study have shown that polymorphisms of the ILIO and TNF genes influence the susceptibility and seventy of uveitis. These polymorphisms were either known to correlate with altered transcription levels, or linked with other polymorphisms positioned within regulatory conserved non-coding sequences. Thus the identification of specific genetic variants that confer susceptibility or resistance t

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Sankaran, David. "Cytokine gene polymorphism and kidney transplant outcome." Thesis, University of Manchester, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.488310.

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The pro-inflammatory cytokine TNF -a. and the immunoregulatory cytokine IL-IO have been implicated in acute rejection of kidney allografts. Similarly, the pro-fibrotic cytokine TGF-IJ 1 has been reported to be involved in the development of chronic rejection. It has also been shown that polymorphisms in the TNFA gene promoter (position -308) and in the TGF-IJI gene (at codon 25) correlate with differential production of these cytokines in vitro. Gene polymorphisms in the IL-IO promoter were also identified previously. However, their function had not been determined. Therefore, the initial part

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McCarthy, Shane. "Comparative sequencing of candidate genes in complex disease /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-663-8/.

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Costa, DÃbora Menezes da. "AssociaÃÃo entre Helicobacter pylori e Polimorfismos em Genes de Interleucinas no CÃncer GÃstrico." Universidade Federal do CearÃ, 2012. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=10142.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>O papel carcinogÃnico de Helicobacter pylori estÃ relacionado Ã sua capacidade de promover a inflamaÃÃo e, como conseqÃÃncia, a metilaÃÃo do DNA, caracterÃstica epigenÃtica frequentemente associada Ã carcinogÃnese gÃstrica. Por sua vez, o processo inflamatÃrio pode ser modulado pela presenÃa de alguns dos polimorfismos presentes em genes de interleucinas, bem como pelo genÃtipo bacteriano. Assim, os objetivos desse estudo foram: a) associar o perfil genotÃpico de virulÃncia de H. pylori (quanto aos genes cagA, cagE, vacA e virB11)

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Matsuzaki, Cezar Noboru. "Análise dos genes CYP1A1,CYP1B1 e CYP17 em meninas com puberdade precoce central." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-18122013-153911/.

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INTRODUÇÃO: Os fatores genéticos que influenciam o início da puberdade precoce ainda não são totalmente conhecidos. Assim, investigar os mecanismos gênicos que estariam envolvidos na sua gênese é muito importante, pois, além de possibilitar o diagnóstico em fases iniciais, pode contribuir para o desenvolvimento de novas terapias, com melhora do prognóstico. Para alguns investigadores, o estradiol também seria um fator contribuinte no determinismo da puberdade. OBJETIVOS: Estudar três genes que codificam enzimas relacionadas à esteroidogênese (CYP1A1, CYP1B1 e CYP17) em meninas com puberdade pr

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Tanrikut, Cihan. "Dna Repair Genes, Xrcc3 And Rad51, Polymorphisms And Risk Of Childhood Acute Lymphoblastic Leukemia." Master's thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12612836/index.pdf.

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In this study, the role of two DNA repair genes, X-ray repair cross complementing group 3 (XRCC3) Thr241Met and Rad51 G135C polymorphisms were investigated in the risk of development of childhood ALL in Turkish population among 193 healthy controls and 184 ALL patients, by using PCR-RFLP technique. For XRCC3 Thr241Met polymorphism, the frequencies of both heterozygous and homozygous mutant genotypes were found to be higher in the controls compared to ALL patients (OR: 0.59, p = 0.02<br>OR: 0.48, p = 0.02, respectively). In addition, either heterozygous (Thr/Met) or homozygous mutant (Met/Me

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Qianren, Jin. "Search for susceptibility loci and candidate genes for breast cancer /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-030-3/.

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39

Ma, Jun. "Identification of the susceptibility genes in type 1 diabetes and diabetic nephropathy /." Stockholm : Karolinska institutet, 2007. http://diss.kib.ki.se/2007/978-91-7357-398-6/.

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40

Zhang, Ying. "Exploring functional genetic variants in genes involved in mental disorders." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186433668.

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41

Tellier, AureÌlien. "A theory of polymorphism in gene-for-gene interactions." Thesis, University of East Anglia, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439932.

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Credidio, Laura 1976. "Polimorfismo C936T do gene VEGF no risco de adenocarcinoma colorretal esporádico e em seus aspectos clínicos e biológicos." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308755.

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Orientadores: Claudio Saddy Rodrigues Coy, Carmen Silvia Passos Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-20T01:34:06Z (GMT). No. of bitstreams: 1 Credidio_Laura_M.pdf: 7330672 bytes, checksum: 03e0aafb86a0b4df9c88c89f064490e2 (MD5) Previous issue date: 2012<br>Resumo: O papel da angiogênese para o desenvolvimento do câncer colorretal (CCR) ainda não é totalmente conhecido. Uma das principais glicoproteínas responsáveis pela angiogênese é o fator de crescimento endotelial vascular (VEGF), acredita-

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Olsson, Jens. "Interplay Between Environment and Genes on Morphological Variation in Perch – Implications for Resource Polymorphisms." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7212.

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Carpen, Jayshan D. "Polymorphisms in the human Period genes." Thesis, University of Surrey, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441716.

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Liu, Shuk Ming. "Single nucleotide polymorphism in human microsomal glutathione s-transferase gene and colorectal cancer /." View Abstract or Full-Text, 2003. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202003%20LIU.

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Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003.<br>Includes bibliographical references (leaves 95-105). Also available in electronic version. Access restricted to campus users.

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Querino, Gislaine Aparecida. "Estudo de associação dos genes HLA-DPA1 e HLA-DPB1 em Hanseníase." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/157166.

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Submitted by Gislaine Aparecida Querino (gislainequerino@hotmail.com) on 2018-09-28T01:32:53Z No. of bitstreams: 1 Querino,GA.pdf: 869186 bytes, checksum: 86a067f5db0e67b546c8ad7691a3d530 (MD5)<br>Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2018-09-28T12:55:41Z (GMT) No. of bitstreams: 1 querino_ga_dr_bot.pdf: 869186 bytes, checksum: 86a067f5db0e67b546c8ad7691a3d530 (MD5)<br>Made available in DSpace on 2018-09-28T12:55:41Z (GMT). No. of bitstreams: 1 querino_ga_dr_bot.pdf: 869186 bytes, checksum: 86a067f5db0e67b546c8ad7691a3d530 (MD5)

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Graciele, Domitila Tenani. "Expressão gênica e haplótipos de genes envolvidos na sinalização celular e o risco para carcinoma hepatocelular." Faculdade de Medicina de São José do Rio Preto, 2016. http://hdl.handle.net/tede/407.

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Submitted by Carvalho Dias João Paulo (joao.dias@famerp.br) on 2018-04-05T17:26:15Z No. of bitstreams: 1 gracieledtenani_dissert.pdf: 2576225 bytes, checksum: 0b7b634cafdb9080cbe9b93e41c2e195 (MD5)<br>Made available in DSpace on 2018-04-05T17:26:15Z (GMT). No. of bitstreams: 1 gracieledtenani_dissert.pdf: 2576225 bytes, checksum: 0b7b634cafdb9080cbe9b93e41c2e195 (MD5) Previous issue date: 2016-12-07<br>Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP<br>Background - Hepatocellular carcinoma (HCC) is highlighted as the most aggressive malignant liver tumor. The identification of

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Afridi, Sarwat. "Influence de variants génétiques candidats sur des phenotypes liés au paludisme à Plasmodium falciparum et effet fonctionnel du polymorphisme NCR3-412 associés au paludisme." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4037.

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Le paludisme est une cause majeure de morbidité et de mortalité, plus particulièrement en Afrique sub-saharienne. De très nombreuses observations sont en faveur de l'existence de facteurs génétiques contrôlant le devenir de l'infection palustre. Il est très probable que certains variants génétiques de gènes candidats du paludisme affectent la résistance du paludisme à travers leur effet sur la réponse immunitaire acquise. Afin de vérifier cette hypothèse, nous avons étudié, dans une population vivant au Burkina Faso, des variants génétiques de HBB, IL4, IL12B, TNF, LTA, FCGR2A et NCR3 dont l'a

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Pandya, Bhavna Kalpesh. "Thiopurine s-methyl transferase gene polymorphism : Clinical correlations." Thesis, University of Manchester, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529233.

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Tomeson, D. "Nucleotide excision repair gene polymorphism and skin cancer." Thesis, University of Edinburgh, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.662988.

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The most important environmental risk factor for skin cancer is sunlight exposure. The genetic component is seen in the inherited genodermatoses, such as Xeroderma Pigmentosum (XP), where there is a 1000-fold increased risk of skin cancer. Nucleotide excision repair (NER), the pathway responsible for removal of UV-induced DNA damage, is defective in XP patients. The XPB and XPD helicases are essential components of the NER pathway. Frequent polymorphisms have been reported in NER genes and polymorphisms in ERCC2, ERCC1 and XPF have been investigated for association with various types of cancer

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