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Relevant bibliographies by topics / Therapeutic Response against Diabetes Mellitus

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Academic literature on the topic 'Therapeutic Response against Diabetes Mellitus'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Therapeutic Response against Diabetes Mellitus"

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Riya, Raj Nivedita chatterjee Sandhya Verma Chandra Shekhar Mishra. "Exploring Diabetes: Types, History, Prevelance and Role of Medicinal Plants in Management." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1569–82. https://doi.org/10.5281/zenodo.15381436.

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Diabetes is a chronic metabolic disorder characterized by elevated blood sugar levels, resulting from either insufficient insulin production or poor cellular response to insulin. This condition is classified into two main types: Type 1 diabetes, where the body fails to produce insulin, and Type 2 diabetes, where the body becomes resistant to insulin. The increasing prevalence of diabetes globally has prompted the exploration of alternative therapeutic approaches, particularly the use of medicinal plants. Several plant species have shown significant antidiabetic activities through mechanisms su

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Ren, Yuanyuan, Zhuozhuo Li, Wenqing Li, et al. "Arginase: Biological and Therapeutic Implications in Diabetes Mellitus and Its Complications." Oxidative Medicine and Cellular Longevity 2022 (October 26, 2022): 1–20. http://dx.doi.org/10.1155/2022/2419412.

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Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L-arginine to urea and L-ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 (ARG2), play a vital role in the regulation of β-cell functions, insulin resistance (IR), and vascular complications via modulating L-arginine metabolism, nitric oxide (NO) production, and inflammatory responses as well as oxidative stress. Basic and clinical studies reveal that abnormal alterations of arginase expression and activity are strongly associated with the onset and development of diabetes mellitus (DM) and its com

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Puddu, Alessandra, Roberta Sanguineti, François Mach, Franco Dallegri, Giorgio Luciano Viviani, and Fabrizio Montecucco. "Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction." Mediators of Inflammation 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/750540.

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The primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia and, ultimately, diabetes mellitus. Therefore, strategies targeting the maintenance of the normal function and protecting pancreatic beta-cells from injury or death might be crucial in the treatment of diabetes. This narrative review will update evidence from the recently identified molecular regulat

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Lanka, Goverdhan, Revanth Bathula, Manan Bhargavi, and Sarita Rajender Potlapally. "Homology modeling and molecular docking studies for the identification of novel potential therapeutics against human PHD3 as a drug target for type 2 diabetes mellitus." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 265–73. http://dx.doi.org/10.22270/jddt.v9i4.3039.

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PHD3 (Prolyl Hydroxylating Domain) 3 protein contains the HRE (Hypoxia Response Element) and plays an important role in regulating HIF subunits. The hydroxylating ability of PHD3 of HIF subunits makes PHD3 is a prominent therapeutic target to control type 2 diabetes mellitus. The structure based approach is used to design novel molecular entities against PHD3 protein. In this present work, a 3D homology model of PHD3 was generated by MODELLER9.9 as the experimental structure of PHD3 is not reported in the protein database. The 3d structural model of PHD3 refined through energy minimization in

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Tebulo, Kintuza Lumwako. "Therapeutic Potential of Citrus Flavonoids in Metabolic Inflammation and Insulin Resistance." Research Output Journal of Engineering and Scientific Research 4, no. 3 (2025): 23–29. https://doi.org/10.59298/rojesr/2025/4.3.2329.

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Metabolic inflammation, or meta-inflammation, is a low-grade chronic inflammatory state associated with metabolic disorders such as obesity, type 2 diabetes mellitus (T2DM), and insulin resistance (IR). Recent evidence highlights the role of bioactive compounds, particularly citrus flavonoids, in modulating metabolic pathways and inflammatory responses. Citrus flavonoids, such as hesperidin, naringenin, nobiletin, and tangeretin, exhibit diverse biological properties including antioxidant, anti-inflammatory, and insulin-sensitizing effects. This review consolidates current findings on the mole

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Sharma, Naveen, Eun-Joo Shin, Nam Hun Kim, et al. "Far-infrared Ray-mediated Antioxidant Potentials are Important for Attenuating Psychotoxic Disorders." Current Neuropharmacology 17, no. 10 (2019): 990–1002. http://dx.doi.org/10.2174/1570159x17666190228114318.

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Far-infrared ray (FIR) is an electromagnetic wave that produces various health benefits against pathophysiological conditions, such as diabetes mellitus, renocardiovascular disorders, stress, and depression etc. However, the therapeutic application on the FIR-mediated protective potentials remains to be further extended. To achieve better understanding on FIR-mediated therapeutic potentials, we summarized additional findings in the present study that exposure to FIR ameliorates stressful condition, memory impairments, drug dependence, and mitochondrial dysfunction in the central nervous system

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Fang, Zhao-hui, Xian-chun Duan, Jin-dong Zhao, Yuan-jie Wu, and Meng-meng Liu. "Novel Polysaccharide H-1-2 from Pseudostellaria Heterophylla Alleviates Type 2 Diabetes Mellitus." Cellular Physiology and Biochemistry 49, no. 3 (2018): 1037–47. http://dx.doi.org/10.1159/000493284.

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Background/Aims: To investigate the potential therapeutic effect of novel polysaccharide H-1-2 from pseudostellaria heterophylla against type 2 Diabetes Mellitus (T2DM) and elucidate the underling molecular mechanisms. Methods: Relative expression of HIF1α and Sirt1 in T2DM patients was determined via real-time PCR. The direct binding of HIF1α on Sirt1 promoter was validated by ChIP assay. The inhibitory regulation of Sirt1 by HIF1α was analyzed using luciferase reporter assay. The endogenous protein of HIF1α and Sirt1 in response to H-1-2 treatment was quantified by western blotting. The bloo

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Yang, Xiumei, Cuilian Yang, Wenjing Lu, and Xiumei Yang. "Visnagin Attenuates Gestational Diabetes Mellitus in Streptozotocin-induced Diabetic Pregnant Rats via Regulating Dyslipidemia, Oxidative Stress, and Inflammatory Response." Pharmacognosy Magazine 19, no. 1 (2022): 31–40. http://dx.doi.org/10.1177/09731296221137440.

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Background: Gestational diabetes mellitus (GDM) is a condition of glucose intolerance and insulin resistance only diagnosed during pregnancy. GDM has exhibited several adverse effects on both mother and offspring. The current research focuses on discovering visnagin’s beneficial properties against the streptozotocin (STZ)-induced GDM in rats via alleviating the inflammation and oxidative stress. Materials and Methods: GDM was caused in the pregnant rats by the administration of 25 mg/kg of STZ by the intraperitoneal route and then treated with 20 mg/kg of visnagin for 20 consecutive days. The

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Abbas, Ghulam, Quazi M. I. Haq, Ahmad Hamaed, Mohammed Al-Sibani, and Hidayat Hussain. "Glucagon and Glucagon-like Peptide-1 Receptors: Promising Therapeutic Targets for an Effective Management of Diabetes Mellitus." Current Pharmaceutical Design 26, no. 4 (2020): 501–8. http://dx.doi.org/10.2174/1381612826666200131143231.

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: G-protein-coupled receptors (GPCRs) are membrane-bound proteins, which are responsible for the detection of extracellular stimuli and the origination of intracellular responses. Both glucagon and glucagon-like peptide-1 (GLP-1) receptors belong to G protein-coupled receptor (GPCR) superfamily. Along with insulin, glucagon and GLP-1 are critical hormones for maintaining normal serum glucose within the human body. Glucagon generally plays its role in the liver through cyclic adenosine monophosphate (cAMP), where it compensates for the action of insulin. GLP-1 is secreted by the L-cells of the

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Tripathi, Deepak, Rajesh Kumar Radhakrishnan, Ramya Sivangala Thandi, et al. "IL-22 reduces the mortality of type 2 diabetes mellitus (T2DM) mice infected with Mycobacterium tuberculosis." Journal of Immunology 202, no. 1_Supplement (2019): 181.19. http://dx.doi.org/10.4049/jimmunol.202.supp.181.19.

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Abstract IL-22 play an important role in protective immune responses against bacterial infections including Mtb and maintains homeostasis by regulating excess inflammation. IL-22 can also regulate glucose homeostasis, suggesting IL-22 pathway as a novel target for therapeutic intervention. Previously, we developed a mouse model of type 2 diabetes mellitus (T2DM) and found that pathological immune response enhances mortality of Mycobacterium tuberculosis (Mtb) infected T2DM mice. In the current study, we determined the role of IL-22 during Mtb infection in T2DM mice. We found innate lymphoid 3

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Dissertations / Theses on the topic "Therapeutic Response against Diabetes Mellitus"

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Kotelban, A. V. "Microbiological assessment of a complex of therapeutic-preventive measures concerning chronic catarrhal gingivitis in children against diabetes mellitus." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/17827.

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"Protective mechanism(s) of anti-oxidants in pancreatic-islet β-cells against glucose toxicity and oxidative stress". 2011. http://library.cuhk.edu.hk/record=b5896936.

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Poon, Chui Wa Christina.<br>"August 2011."<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 123-131).<br>Abstracts in English and Chinese.<br>ABSTRACT --- p.i<br>論文摘要 --- p.vi<br>ACKNOWLEDGEMENTS --- p.ix<br>PUBLICATIONS --- p.x<br>Abstracts --- p.x<br>ABBREVIATIONS --- p.xii<br>Chapter 1. --- GENERAL INTRODUCTION --- p.1<br>Chapter 1.1. --- Diabetes --- p.1<br>Chapter 1.1.1. --- Overview --- p.1<br>Chapter 1.1.2. --- Diagnostic Criteria of Type-2 Diabetes --- p.2<br>Chapter 1.1.3. --- Type-2 Diabetes (T2DM) --- p.3<br>Chapte

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"Phycocyanin protects INS-1E pancreatic beta cells against human islet amyloid polypeptide-induced apoptosis through attenuating oxidative stress and mitochondrial dysfunction." Thesis, 2010. http://library.cuhk.edu.hk/record=b6075047.

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Additionally, cyclosporin A, an inhibitor of the mitochondrial permeability transition (MPT) pore, failed to prevent hIAPP-induced DeltaPsim collapse, cytochrome c and AIF release and caspase-3 activation, indicating that the MPT pore was not involved in hIAPP-induced apoptosis. On the other hand, potential crosstalk between the extrinsic and intrinsic apoptotic pathways was demonstrated by cleavage of Bid by caspase-8 in the apoptotic process triggered by hIAPP.<br>It is widely accepted that human islet amyloid polypeptide (hIAPP) aggregation plays an important role in the loss of insulin-pro

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Book chapters on the topic "Therapeutic Response against Diabetes Mellitus"

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Uguz, A. Cihangir. "The Role of Ion Channels in Diabetes Mellitus." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.11.

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The role of ion channels in diabetes mellitus encompasses their critical involvement in regulating cellular functions central to glucose metabolism and insulin secretion. Ion channels, such as potassium (K+) channels and calcium (Ca2+) channels, play pivotal roles in pancreatic beta cells where they govern insulin secretion in response to changes in blood glucose levels. ATP-sensitive K+ channels (KATP channels) mediate glucose-stimulated insulin secretion by modulating cell membrane potential and calcium influx, essential for triggering insulin release. Dysfunction or dysregulation of these i

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Osmanoglu, Usame Omer. "The Use of Artificial Intelligence in the Diagnosis and Treatment of Diabetes." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.15.

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Artificial intelligence (AI) is increasingly transforming the landscape of diabetes diagnosis and treatment by leveraging data-driven approaches to enhance precision and efficiency in healthcare. AI algorithms analyze vast amounts of patient data, including medical records, genetic profiles, and real-time physiological metrics from wearable devices, to identify patterns and predict disease progression. In diagnostics, AI-powered systems can interpret complex datasets to facilitate early detection of diabetes and its complications, such as diabetic retinopathy and nephropathy, improving clinica

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Gumus, Hatice Hale. "Triggering Role of Viruses and Bacteria in Type I Diabetes." In Current Multidisciplinary Approach to Diabetes Mellitus Occurrence Mechanism. Nobel Tip Kitabevleri, 2023. http://dx.doi.org/10.69860/nobel.9786053359104.13.

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The triggering role of viruses and bacteria in type 1 diabetes (T1D) involves complex interactions between genetic susceptibility, environmental factors, and the immune system. Viruses, particularly enteroviruses such as Coxsackievirus B, have been implicated in triggering autoimmune responses that lead to the destruction of insulin-producing beta cells in the pancreas. These viruses can infect pancreatic beta cells directly or trigger an inflammatory response that activates autoreactive T cells, which mistakenly attack and destroy beta cells. Additionally, viral infections may disrupt immune

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Tripathi, Pratima. "Immunosuppression in Patients with Diabetes Mellitus." In Immunosuppression and Immunomodulation [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.107362.

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Diabetes is an age-dependent health issue prevalent worldwide and specially seen in those families with prevalent history of the disorder. Insufficient insulin production by the defective pancreas that leads to high blood glucose levels in the systemic circulation makes the patients more prone to an infection that exaggerates with time as compared to their counterparts. This increased prevalence of infections in diabetics may be due to defects in the immune functionality of the diabetes patients. High blood glucose level evokes inflammatory responses due to provoked inflammatory immune respons

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Shaw, James A. M., and Kevin Docherty. "Gene therapy in diabetes mellitus." In Oxford Textbook of Endocrinology and Diabetes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235292.003.1603.

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The distinctions between what has previously been termed cell therapy and gene therapy have become blurred. Cell therapy traditionally implied the in vitro expansion of cells that could subsequently be engrafted into patients to elicit a therapeutic effect, while gene therapy was a term applied to the genetic manipulation of tissues or cells in vivo or ex vivo. With the amazing advances that have been achieved using transcription factors to reprogramme cells, this distinction, at least for regenerative medicine applications, no longer exists. In this chapter, following the statement of the unm

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Ogweno, Gordon, and Edwin Murungi. "Controversies in Platelet Functions in Diabetes Mellitus Type 1." In Type 1 Diabetes Mellitus [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108276.

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Individuals with diabetes mellitus (DM) are at high risk of thrombosis in which hyperactive platelets are implicated. The platelet hyperactivity has been linked to hyperglycemia. This hypothesis is supported by studies in type II diabetes mellitus showing increased sensitivity of platelets to stimulating agonists in the context of tissue resistance to high-circulating insulin. However, controversy still exists regarding the altered platelet functions in type 1 diabetes mellitus (T1DM) and the link to modifying factors such as blood glucose, hyperlipidemia, metabolic acidosis and insulin treatm

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Savage, David A., and Stephen C. Bain. "Genetics of type 1 diabetes mellitus." In Oxford Textbook of Endocrinology and Diabetes. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199235292.003.1316.

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Type 1 diabetes, previously known as insulin-dependent diabetes mellitus, is a common chronic T-cell-mediated disease in which there is selective autoimmune destruction of the insulin-producing β‎ cells of the pancreas. Although the mechanisms underlying this process are not fully understood, type 1 diabetes occurs as a result of complex interactions between multiple genes (reviewed in references 1–3) and environmental influences, which may both promote and protect against disease. Type 1 diabetes clusters in some families, but with no distinct pattern of inheritance. The concordance rates in

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Chand, Ammara, Saima Ali, and Saikh Mohammad Wabaidur. "Phytochemistry, Ethnobotany, Biogenesis, and Pharmacological Wonders of Cumin Seeds." In Therapeutic and Pharmacological Applications of Ethnobotany. IGI Global, 2024. http://dx.doi.org/10.4018/979-8-3693-1986-4.ch006.

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There are two primary varieties of cumin: white and black. White cumin seeds are more widely available, while black cumin seeds are smaller and smell sweeter. Cumin is an annual herb that grows to average heights of 30 to 45 cm in regions with sunshine and rainfall. The antifungal properties of this oil also extended the shelf life of strawberry fruit. Because cuminaldehyde is present in cumin seeds, individuals ill with diabetes mellitus benefited from its anti-diabetic properties. In alloxan-diabetic rats, dietary cumin prevented hyperlipidemia, which led to diabetes. Rats were used in the e

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Lima, Mercia Mendes de, William Augustine Rodrigues, John Peter Vasconcelos, Igor Gomes de Araújo, and Arlandia Cristina Lima Nobre de Morais. "Therapeutic perspective of COVID-19 against corticosteroids." In DEVELOPMENT AND ITS APPLICATIONS IN SCIENTIFIC KNOWLEDGE. Seven Editora, 2023. http://dx.doi.org/10.56238/devopinterscie-217.

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Coronaviruses belong to a broad family called Coronoviridae, they are simple RNA viruses. In SARS-CoV-2 infection, a cytokine storm occurs in the body, responsible for tissue damage, and pulmonary and systemic inflammation. For this reason, corticosteroids appear as a viable option. This study conducted a systematic review of the pharmacotherapy of steroidal anti-inflammatory drugs used in hospitalized patients with COVID-19. The study was conducted in January 2023, using the SCIELO and PUBMED databases. The keywords were: corticosteroid, SARS-CoV-2, therapy, corticosteroids, hospitalized, and

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Nogara, Pablo A., Meire E. Pereira, Claudia S. Oliveira, Laura Orian, and João B. T. da Rocha. "The Long Story of Ebselen: From about One Century of its Synthesis to Clinical Trials." In Chalcogen Chemistry: Fundamentals and Applications. The Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/bk9781839167386-00567.

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The first synthesis of Ebselen was nearly a full century ago, but despite several clinical trials with Ebselen, the therapeutic application of Ebselen is still uncertain. Nevertheless, it has very low toxicity and its broad activity in the modulation of the redox equilibrium indicates that Ebselen can be a multitarget therapeutic agent against human diseases. Here we will review nearly a dozen clinical trials with Ebselen to treat brain ischemia, cardiovascular problems associated with diabetes mellitus, noise-induced hearing loss, and bipolar disorder. The molecular events potentially mediati

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Conference papers on the topic "Therapeutic Response against Diabetes Mellitus"

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Abdelsalam, Shahenda Salaheldine, and Abdelali Agouni. "Protein Tyrosine Phosphatase (PTP) 1B Inhibition Improves Endoplasmic Reticulum Stress-Induced Apoptosis and Impaired Angiogenic Response in Endothelial Cells." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0110.

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Insulin is not only important for glucose homeostasis, but also plays a critical role in the activation of endothelial nitric oxide synthase (eNOS) to synthesize nitric oxide (NO) and keeping the endothelium functional. Conditions which result in insulin resistance, such as diabetes and obesity, cause impairment of endothelial function, a condition known as endothelial dysfunction that features a reduced release of NO. Protein tyrosine phosphatase (PTP) 1B, is a known negative regulator of insulin receptor, that has been implicated in the pathogenesis of insulin resistance and endothelial dysf

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Zanarel, Palomali, Marina Grigoli, Danielle de Oliveira, Patrícia Manzine, and Márcia Cominetti. "IFG-1 PLASMA LEVELS ARE ALTERED IN PATIENTS WITH ALZHEIMER’S DIASEASE AND DIABTES MELLITUS TYPE 2." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda045.

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Background: Insulin plays an important role in mechanisms related to brain activity and in memory formation. Alterations in the insulin pathway may be related to Alzheimer’s disease (AD) and patients with type 2 diabetes mellitus (DM2) are more likely to develop AD, compared to metabolically and cognitively healthy individuals. Objectives: To evaluate the IGF-1 levels in plasma samples from individuals with AD or DM2 isolated or with both diseases concomitantly and to compare with the levels from cognitively and metabolically healthy older adults. Methods: This is a cross-sectional, descriptiv

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