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Journal articles on the topic 'Thiol group'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

QUIJANO, Celia, Beatriz ALVAREZ, Reynaldo M. GATTI, Ohara AUGUSTO, and Rafael RADI. "Pathways of peroxynitrite oxidation of thiol groups." Biochemical Journal 322, no. 1 (1997): 167–73. http://dx.doi.org/10.1042/bj3220167.

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Peroxynitrite mediates the oxidation of the thiol group of both cysteine and glutathione. This process is associated with oxygen consumption. At acidic pH and a cysteine/peroxynitrite molar ratio of ≤ 1.2, there was a single fast phase of oxygen consumption, which increased with increasing concentrations of both cysteine and oxygen. At higher molar ratios the profile of oxygen consumption became biphasic, with a fast phase (phase I) that decreased with increasing cysteine concentration, followed by a slow phase (phase II) whose rate of oxygen consumption increased with increasing cysteine conc

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2

Ovchinnikova, S. N., and T. P. Aleksandrova. "Effect of solution composition on the desorption behavior of self-assembled monolayers of alkanethiols with different terminal groups." Èlektrohimiâ 60, no. 4 (2024): 300–308. http://dx.doi.org/10.31857/s0424857024040042.

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Voltammetry and chronoamperometry are used to study the effect of the composition of a solution on the desorption behavior of self-assembled monolayers (SAMs) of alkanethiols with approximately the same chain length but different end groups of thiols (R: –CH3, –CH2OH, and –NH2). The hydrophilic properties of terminal groups for the studied thiols increase in the –CH3 –NH2 ≤ –CH2OH series. It has been found that the anion and cation compositions of electrolyte significantly affect the electrochemical stability and blocking ability of SAMs of thiols with different terminal groups. It has been es

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3

Bannwart, Linda M., Pascal S. Rieder, and Marcel Mayor. "2-(3-Cyanopropyldimethylsilyl)ethyl as a Polar Sulfur Protecting Group." Synthesis 51, no. 22 (2019): 4153–64. http://dx.doi.org/10.1055/s-0039-1690184.

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Organosulfur compounds are ubiquitous in synthetic chemistry, biology and materials chemistry. The reactivity of free sulfhydryls requires their masking in many synthetic strategies. To facilitate the isolation of protected thiols by chromatography, we propose 2-(3-cyanopropyldimethylsilyl)ethyl as a polar protecting group analogue of 2-(trimethylsilyl)ethyl. The masked thiophenol is obtained in two synthetically complementing ways. Either an existing thiophenol is protected, or the protected thiol group is introduced by a cross-coupling reaction. In both cases the required reagents are readil

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4

Ozyurt, Songul, Neslihan Ozcelik, Bilge Yilmaz Kara, et al. "Evaluation of Thiol/Disulfide Homeostasis in Bronchiectasis." Canadian Respiratory Journal 2022 (January 29, 2022): 1–6. http://dx.doi.org/10.1155/2022/8340450.

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Purpose. Thiols are sulfhydryl-containing organic compounds that have an important role in preventing cellular oxidative stress. This study compares the blood oxidative stress marker levels in bronchiectasis cases during their stable periods with healthy controls. Materials and Methods. Seventy-seven patients (49 patients with stable bronchiectasis/28 healthy controls), followed up by the chest disease clinic, were included in the study. Peripheral blood thiol-disulfide parameters (NT: native thiol (−SH); TT: total thiol (−SH + SS); SS: disulfide (−SS); SS-SH: disulfide/native thiol index; SS-

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5

Ayar, Ganime, Sanliay Sahin, Mutlu Uysal Yazici, Salim Neselioglu, Ozcan Erel, and Umut Selda Bayrakcı. "Effects of Hemodialysis on Thiol-Disulphide Homeostasis in Critically Ill Pediatric Patients with Acute Kidney Injury." BioMed Research International 2018 (September 25, 2018): 1–6. http://dx.doi.org/10.1155/2018/1898671.

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Aim. To evaluate thiol/disulphide homeostasis as a new indicator of oxidative stress in AKI patients and to determine the effect of HD on antioxidant balance and oxidative stress through plasma thiols. Methods. This study was performed in patients aged between 12 months and 18 years prospectively who underwent hemodialysis due to AKI and were followed up for a year in a 22-bed tertiary pediatric intensive care unit. 20 patients and 39 controls were included. Results. No difference was present between the groups in terms of age and gender. Median values of plasma native thiol, total thiol, and

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Veksler, Kirill V., and Evgenia N. Volkov. "HYDROPHOBIC AROMATIC THIO (DITHIO) COMPOUNDS AS CHROMOGENIC ANALYTICAL REAGENTS FOR PHOTOMETRIC DETERMINATION OF THIOLS BY MERCAPTO GROUP III. ANALYTICAL REAGENTS IN WATER-MICELLAR SOLUTIONS OF CATIONIC SURFACTANTS." Bulletin of the Saint Petersburg State Institute of Technology (Technical University) 67 (2023): 53–58. http://dx.doi.org/10.36807/1998-9849-2023-67-93-53-58.

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It was discovered for the first time the ability of a number of hydrophobic aromatic azothio (dithio) compounds, chromogenic analytical reagents to the mercapto group in dipolar aprotic solvents (SH- reagents), to react in aqueous solutions of cationic surfactants with sulfhydryl compounds (SH- compounds) by the type of "thiol-thiol" substitution with manifestation of significant analytical effects (AE). Photometry of hydrophobic thiols is possible by preliminary extraction of the latter with a solution of the SH- reagent from a solution in an acyclic ultimate hydrocarbon. The "thiol-thiol" su

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7

Skaff, Ojia, David I. Pattison, and Michael J. Davies. "Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance." Biochemical Journal 422, no. 1 (2009): 111–17. http://dx.doi.org/10.1042/bj20090276.

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MPO (myeloperoxidase) catalyses the oxidation of chloride, bromide and thiocyanate by H2O2 to HOCl (hypochlorous acid), HOBr (hypobromous acid) and HOSCN (hypothiocyanous acid, also know as cyanosulfenic acid) respectively. Specificity constants indicate that thiocyanate, SCN−, is a major substrate for MPO. HOSCN is also a major oxidant generated by other peroxidases including salivary, gastric and eosinophil peroxidases. Whereas HOCl and HOBr are powerful oxidizing agents, HOSCN appears to be a less reactive, but more thiol-specific oxidant. Although it is established that HOSCN selectively t

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8

Bednářová, Eva, Simona Hybelbauerová та Jindřich Jindřich. "Optimized methods for preparation of 6I-(ω-sulfanyl-alkylene-sulfanyl)-β-cyclodextrin derivatives". Beilstein Journal of Organic Chemistry 12 (24 лютого 2016): 349–52. http://dx.doi.org/10.3762/bjoc.12.38.

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A general high-yielding method for the preparation of monosubstituted β-cyclodextrin derivatives which have attached a thiol group in position 6 is described. The thiol group is attached through linkers of different lengths and repeating units (ethylene glycol or methylene). The target compounds were characterized by IR, MS and NMR spectra. A simple method for their complete conversion to the corresponding disulfides as well as a method for the reduction of the disulfides back to the thiols is presented. Both, thiols and disulfides are derivatives usable for well-defined covalent attachment of

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9

Fadime, Kilinc, Sener Sertac, Akbas Ayse, Neselioglu Salim, Erel Ozcan, and Aktas Akin. "Investigation of Dynamic Thiol-Disulfide Homeostasis in Alopecia Areata Patients." British Journal of Medicine & Medical Research 21, no. 6 (2017): 1–7. https://doi.org/10.9734/BJMMR/2017/33535.

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<strong>Background: </strong>Thiols are antioxidant, organic compounds containing sulfhydryl group on their active sites. They have important roles on preventing oxidative stress. The thiol disulfide homeostasis has a vital importance in organism. Thiol disulfide imbalance is an early indicator of oxidative stress. Alopecia areata is an autoimmune skin disorder characterized with scar-free hair loss. Its pathogenesis is still unclear. Thiol disulfide homeostasis in these patients has not been studied at all. <strong>Objective: </strong>To evaluate the thiol disulfide homeostasis in alopecia ar

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10

Jaschke, M., H. Wolf, H. Schönherr, H. Ringsdorf, E. Bamberg, and H. J. Butt. "The molecular structure of thiol-monolayers on gold imaged with an Atomic Force Microscope." Proceedings, annual meeting, Electron Microscopy Society of America 53 (August 13, 1995): 714–15. http://dx.doi.org/10.1017/s0424820100139949.

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Thiols spontaneously form monolayers on gold. An important question is which factors determine the structure of the thiols. The two extreme positions are: (a) the structure of the underlying gold determines the packing of the thiol molecules; (b) the geometry of the thiol molecules and the interaction between thiols determine their two-dimensional structure.To help answer this question two series of thiol molecules on gold (111) were imaged by atomic force microscopy. In order to reduce the force between tip and sample, and to prevent distortion of the thiol monolayer, all images were taken in

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11

Rieger, Paul, Sabrina Pueschmann, Michael Haas, Max Schmallegger, Gema Guedes de la Cruz, and Thomas Griesser. "Exploring Aromatic S-Thioformates as Photoinitiators." Polymers 15, no. 7 (2023): 1647. http://dx.doi.org/10.3390/polym15071647.

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Thiyl radicals were generated from aromatic S-thioformates by photolysis. The corresponding photo-initiated decarbonylation allows initiating polymerization reactions in both acrylate- and thiol-acrylate-based resin systems. Compared to aromatic thiols, the introduction of the photolabile formyl group prevents undesired reactions with acrylate monomers allowing photoinitiators (PIs) with constant reactivity over storage. To demonstrate the potential of S-thioformates as PIs, the bifunctional molecule S,S′-(thiobis(4,1-phenylene))dimethanethioate (2b) was synthesized, providing reactivity under

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12

QUINLAN, Gregory J., Michael P. MARGARSON, Sharon MUMBY, Timothy W. EVANS, and John M. C. GUTTERIDGE. "Administration of albumin to patients with sepsis syndrome: a possible beneficial role in plasma thiol repletion." Clinical Science 95, no. 4 (1998): 459–65. http://dx.doi.org/10.1042/cs0950459.

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1.Albumin is often administered intravenously to critically ill patients as a volume expander, to combat hypoalbuminaemia, and to decrease hyperbilirubinaemia. There is, however, an ongoing debate concerning the therapeutic benefit of the former which is an expensive form of treatment. 2.Albumin has several biological functions, in particular as a ligand binder. It also acts as an extracellular transition metal ion-binding and radical-scavenging antioxidant. These functions are influenced by the presence of an exposed thiol group (cys 34) on the surface of the albumin molecule. 3.The ability o

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13

Alexander, S. R., D. Lim, Z. Amso, M. A. Brimble, and A. J. Fairbanks. "Protecting group free synthesis of glycosyl thiols from reducing sugars in water; application to the production of N-glycan glycoconjugates." Organic & Biomolecular Chemistry 15, no. 10 (2017): 2152–56. http://dx.doi.org/10.1039/c7ob00112f.

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Un-protected 2-acetamido terminated reducing sugars may be converted into the corresponding glycosyl thiols in water, and conjugated to peptides using the thiol–ene click reaction without recourse to any protecting groups.

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14

Halil, Halit, Nilden Tuygun, Erhan Aksoy, Ozcan Erel, and Can Demir Karacan. "Serum Thiol-Disulphide Levels in Epileptic Pediatric Patients." Combinatorial Chemistry & High Throughput Screening 22, no. 1 (2019): 65–68. http://dx.doi.org/10.2174/1386207322666190305135043.

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Background: Epilepsy is a serious clinical condition characterized by recurrent seizures. Oxidative stress plays an important role in the etio-pathogenesis of epilepsy. Measurements of serum thiol and disulfide levels were used to evaluate the antioxidant status of the body. Objective: The aim of this study was to determine serum levels of thiol and disulfide in epileptic pediatric patients. Methods: Ninety patients, 54 epilepsy and 36 controls were included in the study. Serum levels of native thiol total thiol and disulfide were measured and disulfide/native, disulfide / total thiol and nati

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15

Warangkar, Suchita C., and Chandrahas N. Khobragade. "Purification, Characterization, and Effect of Thiol Compounds on Activity of the Erwinia carotovora L-Asparaginase." Enzyme Research 2010 (November 1, 2010): 1–10. http://dx.doi.org/10.4061/2010/165878.

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L-asparaginase was extracted from Erwinia carotovora and purified by ammonium sulfate fractionation (60–70%), Sephadex G-100, CM cellulose, and DEAE sephadex chromatography. The apparent Mr of enzyme under nondenaturing and denaturing conditions was 150 kDa and kDa, respectively. L-asparaginase activity was studied in presence of thiols, namely, L-cystine (Cys), L-methionine (Met), N-acetyl cysteine (NAC), and reduced glutathione (GSH). Kinetic parameters in presence of thiols (10–400 M) showed an increase in values (2000, 2223, 2380, 2500, and control 1666.7 moles ) and a decrease in values (

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16

Podhradský, Dušan, Helena Paulíková, and Ján Imrich. "Reactions of N-tricyanovinylamines with thiols in aqueous solutions." Collection of Czechoslovak Chemical Communications 55, no. 6 (1990): 1630–34. http://dx.doi.org/10.1135/cccc19901630.

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Kinetics of reactions between N-substituted tricyanovinylamines and thiols, where primarily reduction of the C=C double bond takes place, was investigated under conditions adequate to physiological ones. The reaction rates did not depend either on the type of the reacting thiol, or on the pH of the medium, but they decreased with the increasing pKa value of the imino group. A quantitative conversion of the thiol peptide glutathione to its oxidized form was evidenced.

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Dişyapar, Mustafa Kaan, Şaban Keleşoğlu, Ahmet Çınar, Özcan Erel, Salim Neşelioğlu, and Yücel Yılmaz. "Evaluation of antioxidant activity in without persistent ST-segment elevation." Intercontinental Journal of Internal Medicine 1, no. 3 (2023): 59–62. http://dx.doi.org/10.51271/icjim-0012.

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Aims: Coronary artery disease is the most common cause of mortality and morbidity worldwide. Oxidative stress is involved in the pathogenesis of many diseases, including atherosclerosis. Thiols are important antioxidants for the elimination of reactive oxygen radicals and oxidative stress. In this study, we aimed to compare patients suffering from without persistent ST-segment elevation (NSTMI) and volunteers with normal coronary arteries in terms of antioxidants. Methods: The study included 105 patients diagnosed with NSTMI and 51 controls. Plasma total thiol, native thiol, and disulfide leve

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Yazıcı, Mutlu U., Ganime Ayar, Semra Çetinkaya, et al. "Evaluation of Thiol/Disulfide Homeostasis in Pediatric Patients with Diabetic Ketoacidosis." Combinatorial Chemistry & High Throughput Screening 23, no. 3 (2020): 185–90. http://dx.doi.org/10.2174/1386207323666200218114331.

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Aim and Objective: This study aimed to investigate the value of Thiol/Disulfide homeostasis in pediatric diabetic ketoacidosis patients suffering from type 1 diabetes mellitus. Materials and Methods: This study featured children who were diagnosed with diabetic ketoacidosis and who were consecutively admitted to pediatric intensive care within one year of their diagnosis. Thiol/disulfide homeostasis was evaluated in 45 pediatric patients suffering from DKA, as well as 45 healthy controls of parallel gender and age. Thiol/disulfide homeostasis parameters were measured using a novel automated me

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Nicolle, Paméla, Alina Gerzhova, Aurélie Roland, et al. "Thiol precursors and amino acids profile of white interspecific hybrid <i>Vitis</i> varieties and impact of foliar urea and sulfur supplementation on the concentration of thiol precursors in <i>Vitis</i> sp. Vidal berries." OENO One 56, no. 3 (2022): 357–69. http://dx.doi.org/10.20870/oeno-one.2022.56.3.4873.

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Thiols are a group of highly potent aroma compounds found in many Vitis vinifera wines. In berries, thiols occur as precursors formed from a thiol attached to an amino moiety (e.g., cysteine and glutathione). Foliar sulfur and urea supplementation has been found to increase thiol precursors in V. vinifera berries. However, such data are still scarce for interspecific hybrid Vitis varieties, despite a growing interest in these cultivars. In this study, eight thiol precursors, 21 amino acids and glutathione (GSH) of seven white hybrid Vitis varieties collected in Quebec, Canada, were quantified

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Akyol, Selahattin, Hazar Harbalıoğlu, Mustafa Gür, Özcan Erel, and Hakim Çelik. "Impact of Disulfide/Thiol Redox Couple on Pulse Wave Velocity in Patients with Normal Coronary Angiography." Koşuyolu Heart Journal 26, no. 2 (2023): 76–82. http://dx.doi.org/10.51645/khj.2023.m356.

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Introduction: The oxidized thiol/disulfide couple has been investigated and reported as a potential risk factor for cardiovascular diseases. Additionally, an increased pulse wave velocity has been identified as a predictor of cardiovascular events. Patients and Methods: 262 patients were included in our study. Native and total thiol levels, total disulfide levels, disulfide per total thiol ratios, native thiol per total thiol ratios, and disulfide per native thiol level ratios were calculated. Results: Patients were divided into Pulse Wave Velocity (PWV) low and PWV high groups. Native and tot

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Ethemoglu, Filiz Banu, Hidir Yilmaz, Gulsum Kavalci, et al. "A Comparison of Thiol/Disulphide Levels of Workers in Operating Rooms and Emergency Healthcare Centers." Acta Medica 49, no. 3 (2018): 1. http://dx.doi.org/10.32552/2018.actamedica.295.

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Objective: Thiol/disulphide homeostasis has a crucial role for life. The aim of this study was to compare thiol/disulphide homeostasis in healthcare professionals working in the operating room (Group 1) and healthcare professionals working in the emergency department (Group 2). Materials-Methods: This was a descriptive study. Fortynine operating room volunteers (Group 1) and 49 emergency department volunteers (Group 2) were included in this study. Thiol and disulphide concentrations were measured using the novel automated measurement method developed by Erel & Neşelioğlu in 2014.&#x0

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P., Pullaiah, Suchitra M. M., and Siddhartha Kumar B. "Protein carbonyls and protein thiols in rheumatoid arthritis." International Journal of Research in Medical Sciences 6, no. 5 (2018): 1738. http://dx.doi.org/10.18203/2320-6012.ijrms20181770.

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Background: Oxidative stress (OS) has an important role in the pathogenesis and progression of rheumatoid arthritis (RA). OS causes protein modification, thereby impairing the biological functions of the protein. This study was conducted to assess the oxidatively modified protein as protein carbonyl content and the antioxidant status as protein thiols, and to study the association between protein carbonyls and protein thiols in RA.Methods: Newly diagnosed RA patients who were not taking any disease modifying anti-rheumatic drugs were included into the study group (n=45) along with age and sex

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Ozyazici, Sefa, Faruk Karateke, Umit Turan, et al. "A Novel Oxidative Stress Mediator in Acute Appendicitis: Thiol/Disulphide Homeostasis." Mediators of Inflammation 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/6761050.

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Aim. To investigate the role of a novel oxidative stress marker, thiol/disulphide homeostasis, in patients diagnosed with acute appendicitis (AA).Methods. In this study, seventy-one (43 male and 28 female) patients diagnosed with AA and 71 (30 male and 41 female) healthy volunteers were included. Age, gender, body mass index (BMI), haemoglobin (Hb), white blood cell (WBC), c-reactive protein (CRP), and thiol/disulphide homeostasis parameters (native thiol, total thiol, disulphide, disulphide/native thiol, native thiol/total thiol, and disulphide/total thiol ratios) were compared between the gr

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Asil, Mehmet, Ramazan Dertli, Murat Biyik, et al. "Dynamic thiol-disulfide homeostasis is disturbed in patients with non-alcoholic fatty liver disease." LaboratoriumsMedizin 42, no. 1-2 (2018): 31–38. http://dx.doi.org/10.1515/labmed-2017-0018.

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AbstractBackground:Oxidative stress has been implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Plasma thiols are major defense mechanisms against oxidative stress and undergo oxidation to form disulfides under oxidative conditions. This study was conducted to investigate thiol-disulfide homeostasis in NAFLD patients.Methods:Thirty patients with biopsy proven non-alcoholic steatohepatitis (NASH), 40 patients with simple steatosis and 50 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measu

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Arican, Sule, Gulcin Hacibeyoglu, Sinan Oguzhan Ulukaya, et al. "Ischemia-modified albumin (IMA) and dynamic thiol-disulfide homeostasis in patients with postherpetic neuralgia." Journal of Laboratory Medicine 43, no. 5 (2019): 257–63. http://dx.doi.org/10.1515/labmed-2018-0211.

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Abstract Background Ischemia-modified albumin (IMA) is an isotype of albumin that increases under oxidative stress, and plasma thiols are main defense mechanisms against oxidative stress. The objective of this study was to investigate thiol-disulfide homeostasis and serum IMA levels in postherpetic neuralgia (PHN) patients. Methods A total of 29 PHN patients and 30 healthy controls were included in the study. Serum total and native thiol concentrations and serum disulfide concentration were measured using the method described by Erel and Neselioglu. The albumin cobalt binding test was used to

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Agan, Veysel, Hakim Celik, Mehmet Ali Eren, et al. "An Investigation of Oxidative Stress and Thiol/Disulphide Homeostasis in Graves’ Disease." Medicina 55, no. 6 (2019): 275. http://dx.doi.org/10.3390/medicina55060275.

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Background and objectives: The aim of this study was to research oxidative stress and thiol/disulphide homeostasis in Graves’ patients. Materials and Methods: The study included 33 Graves’ patients (research group) and 35 healthy subjects (control group). Serum oxidative stress and thiol/disulphide homeostasis (a new and automated spectrophotometric method developed by Erel and Neselioglu) parameters were studied and compared between the groups. Results: The native and total thiol levels and the native thiol/total thiol ratio were lower in patients with Graves’ disease compared to the control

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Yılmaz Deveci, Mehmet Zeki, and Hüseyin Erdal. "Determination of dynamic thiol-disulfide levels in dairy cattle with foot disease." Veterinarski arhiv 92, no. 6 (2023): 657–66. http://dx.doi.org/10.24099/vet.arhiv.1785.

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Foot diseases are among the top three causes of economic loss in dairy cattle. Recent studies show that oxidative stress plays a critical role in the pathogenesis of foot diseases. There is no study determining the dynamic thiol-disulfide levels in dairy cattle with foot disease. This study aimed to determine dynamic thiol-disulfide levels in foot diseased and healthy dairy cattle. Demographic information about the animals, and clinical findings of foot diseases and lameness were presented. In the Foot Disease Group, native thiol (P<0.01), total thiol (P<0.05), disulfide (P<0.01), dis

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Taş, Onur, Semistan Kızıltepe, Büşra Şahin, Sena Çenesiz, Yunus Kılıçoğlu, and Rahşan Koç Akpınar. "Evaluation of Oxidative Stress Parameters in Leptospira Infected Sheep." Animal Health Production and Hygiene 14, no. 1 (2025): 23–30. https://doi.org/10.53913/aduveterinary.1636302.

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Leptospirosis is a bacterial infection with zoonotic character which is widespread all over the world, especially in humid and temperate regions and poses a serious threat to public health. In this study, 94 sheep blood sera sent to Samsun Veterinary Control Institute Directorate with suspicion of leptospirosis were firstly subjected to ELISA test for leptospirosis antibodies. Total thiol, Native thiol, Disulphide, Native thiol/Total thiol, Disulphide/Native thiol, Disulphide/Total thiol, MDA levels and ADA activity were evaluated in the samples. According to the results of the ELISA test perf

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Acimovic, Jelena, Bojana Stanimirovic, and Ljuba Mandic. "The role of the thiol group in protein modification with methylglyoxal." Journal of the Serbian Chemical Society 74, no. 8-9 (2009): 867–83. http://dx.doi.org/10.2298/jsc0909867a.

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Methylglyoxal is a highly reactive ?-oxoaldehyde with elevated production in hyperglycemia. It reacts with nucleophilic Lys and Arg side-chains and N-terminal amino groups causing protein modification. In the present study, the importance of the reaction of the Cys thiol group with methylglyoxal in protein modification, the competitiveness of this reaction with those of amino and guanidine groups, the time course of these reactions and their role and contribution to protein cross-linking were investigated. Human and bovine serum albumins were used as model systems. It was found that despite th

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Arjona, Odón, Fátima Iradier, Rocío Medel, and Joaquín Plumet. "p-Toluenesulfonylacetylene as Thiol Protecting Group." Journal of Organic Chemistry 64, no. 16 (1999): 6090–93. http://dx.doi.org/10.1021/jo990308c.

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Erduran, Funda, Esra Adışen, Ahmet Soyugür, Funda Eren, Salim Neşelioğlu, and Özcan Erel. "Evaluation of Oxidative Stress by Thiol/Disulphide Homeostasis in Patients with Mycosis Fungoides: A Prospective Double-Centre Study." Indian Journal of Dermatology 68, no. 6 (2023): 724. http://dx.doi.org/10.4103/ijd.ijd_339_23.

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Abstract Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma with unknown etiopathogenesis. Oxidant and antioxidant balance is important for cell function and normal metabolism. An imbalance between pro-oxidants and antioxidants causes oxidative stress. A recent focus has been on thiol/disulphide homeostasis as a novel marker of oxidative stress. Aims and Objectives: This study aimed to evaluate the role of oxidative stress in MF by analysing thiol/disulphide homeostasis. Materials and Methods: A total of 103 patients (48 female, 55 male) and a control group of 120

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Liu, Zhengkun, Qianqian Wang, Hao Wang, Wenting Su, and Shouliang Dong. "A FRET Based Two-Photon Fluorescent Probe for Visualizing Mitochondrial Thiols of Living Cells and Tissues." Sensors 20, no. 6 (2020): 1746. http://dx.doi.org/10.3390/s20061746.

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Glutathione (GSH) is the main component of the mitochondrial thiol pool and plays key roles in the biological processes. Many evidences have suggested that cysteine and homocysteine also exist in mitochondria and are interrelated with GSH in biological systems. The fluctuation of the levels of mitochondrial thiols has been linked to many diseases and cells’ dysfunction. Therefore, the monitoring of mitochondrial thiol status is of great significance for clinical studies. We report here a novel fluorescence resonance energy transfer based two-photon probe MT-1 for mitochondrial thiols detection

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Xia, Yanqing, Hongwu Tian, Yanlei Li, et al. "Kinetic Analysis of the Reduction Processes of a Cisplatin Pt(IV) Prodrug by Mesna, Thioglycolic Acid, and Thiolactic Acid." Journal of Chemistry 2020 (November 11, 2020): 1–12. http://dx.doi.org/10.1155/2020/5868174.

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Although Mesna is an FDA-approved chemotherapeutic adjuvant and an antioxidant based largely on its antioxidative properties, kinetic and mechanistic studies of its redox reactions are limited. A kinetic analysis of the reduction processes of cis-diamminetetrachloroplatinum(IV) (cis-[Pt(NH3)2Cl4], a cisplatin Pt(IV) prodrug) by thiol-containing compounds Mesna, thioglycolic acid (TGA), and DL-thiolactic acid (TLA) was carried out in this work at 25.0°C and 1.0 M ionic strength. The reduction processes were followed under pseudo-first-order conditions and were found to strictly obey overall sec

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Uğur, Cüneyt, Hasan Madenci, Hüseyin Kurku, and Salim Neşelioğlu. "The Use of Thiol/Disulfide Homeostasis Parameters in the Diagnosis of Acute Appendicitis in Children." Journal of Pediatric Infectious Diseases 15, no. 04 (2020): 195–99. http://dx.doi.org/10.1055/s-0040-1709700.

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Abstract Objective The aim of this study was to determine the role of thiol/disulfide homeostasis (TDH) parameters which are new oxidative stress markers for the diagnosis of acute appendicitis (AA) in children with abdominal pain complaints. Methods A total of 40 patients with AA and 45 patients with abdominal pain were included in this study. Two groups were compared in terms of age, gender, white blood cell count, neutrophil-to-lymphocyte ratio, C-reactive protein (CRP), appendix diameter, and TDH parameters (native and total thiol levels, native thiol/total thiol ratio [antioxidant paramet

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Atalay Mert, Sule, Berna Dilbaz, Tugba Kinay, et al. "Evaluation of Oxidative Stress with "Dynamic Thiol/Disulfide Homeostasis" in Cases with Endometrioma." Medical Science and Discovery 9, no. 8 (2022): 458–64. http://dx.doi.org/10.36472/msd.v9i8.784.

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Objective: This preliminary study aims to use "dynamic thiol/disulfide homeostasis" with the new Erel method to evaluate the effect of oxidative stress in patients with endometrioma. Material and Method: The study group consisted of 40 cases with histologically confirmed endometrioma, and 40 women with no laparoscopically confirmed endometriosis were taken as the control group. Plasma thiol, total thiol (TT), and disulfide (SS) levels were measured with the new, fully automatic method described by Erel and Neselioglu. Serum Ca-125, sedimentation (Sed), C-reactive Protein (CRP), and thiol/disul

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Gulpamuk, Bayram, Ufuk Elgin, Emine Sen, Pelin Yilmazbas, Salim Neselioglu, and Ozcan Erel. "Evaluation of dynamic thiol–disulfide homeostasis in glaucoma patients and the correlation with retinal nerve fiber layer analysis." European Journal of Ophthalmology 30, no. 4 (2019): 690–99. http://dx.doi.org/10.1177/1120672119839582.

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Purpose: The aim of this study was to evaluate thiol/disulfide homeostasis and ischemia-modified albumin levels with primary open-angle glaucoma, ocular hypertension, and control group; also to interpret the correlation between these biochemical parameters and retinal nerve fiber layer analysis. Material and methods: In a prospective cross-sectional study, 30 primary open-angle glaucoma cases, 30 ocular hypertension cases, and 30 control subjects were included in the study. Native thiol, total thiol, and disulfide measurements and disulfide/native thiol, disulfide/total thiol, and native thiol

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Dumlu, Ersin Gürkan, Mehmet Tokaç, Mustafa Özsoy, et al. "Determination of Dynamic Plasma Thiol -disulfide Homeostasis with a Novel Technique in Intestinal Ischemia Reperfusion Injury." European Journal of Clinical Medicine 2, no. 3 (2021): 55–59. http://dx.doi.org/10.24018/clinicmed.2021.2.3.83.

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Introduction: Intestinal ischemia/reperfusion (I/R) is a serious life-threatening clinical case. Overproduction of reactive oxygen species (ROS) associated with oxidative stress plays a key role in I/R pathophysiology. Objective: The aim of this study is to evaluate dynamic thiol / disulfide hemostasis in intestinal I/R in rats. Materials and Methods: 24 Winstar albino rats were divided into 3 groups (8 animals in each group: (1) sham (operation without ischemia), (2) ischemia (90 minutes ischemia), (3) ischemia/reperfusion (after ischemia for 30 minutes reperfusion for 60 minutes)

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Koç Akpınar, Rahşan, Sena Çenesiz, Büşra Şahin, et al. "Investigation of Oxidative Stress Parameters in Brucella Infected Sheep and Goats." Animal Health Production and Hygiene 14, no. 1 (2025): 1–9. https://doi.org/10.53913/aduveterinary.1592505.

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Brucella infection is a common zoonotic disease in sheep and goats and is associated with various clinical signs and immune responses after infection. Oxidative stress is believed to have a significant impact on the pathophysiological mechanisms of this infection. The aim of this study was to investigate oxidative stress parameters in blood serum of Brucella infected sheep and goats. In the study conducted in Samsun province, 1831 sheep and 182 goat samples were examined; 30 Brucella positive sheep-goat sera and 30 healthy sheep-goat sera were used for biochemical analyses. In the samples, tot

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Cicek, Cigdem, Veysel Baskin, and Kevser Erol. "Effects of NO, H2S and CO on Thiol/Disulfide Balance and Advanced Oxidation Protein Products in Hippocampus and Serum." Yüksek İhtisas Üniversitesi Sağlık Bilimleri Dergisi 4, no. 1 (2023): 7–12. http://dx.doi.org/10.51261/yiu.2023.00059.

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Introduction: Nitric oxide (NO), hydrogen sulfide (H2S), and carbon monoxide (CO) are known as gaseous autocoids. It is not clear how the application of exogenous NO, H2S and CO alters the thiol/disulfide balance and advanced oxidation protein products (AOPPs) in the hippocampus and serum. Materials and Methods: In the study, rats were exogenously injected with L-arginine (100 mg/kg) as a NO donor, NaHS (10 mg/ kg) as a H2S donor, and CORM-2 (10 mg/kg) as a CO donor (II) (a tricarbonyldichlororuthenium dimer). Thiol/disulfide balance and advanced protein oxidation products were analyzed in hip

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Akinloye, D. I., R. N. Ugbaja, A. J. Akamo, et al. "Effects of alcohol-graded concentrations on total thiols and some thiol utilizing enzymes." Bayero Journal of Pure and Applied Sciences 15, no. 1 (2022): 202–9. http://dx.doi.org/10.4314/bajopas.v15i1.29.

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Excessive intake of alcohol has been documented to initiate different pathological conditions. Although various researchers have reported these associations, the modulatory effects on endogenous thiols are not well studied. This study investigated the effects of alcohol-graded concentrations on some thiol utilizing enzymes in rats. Adults’ male rats were divided into four main groups and treated with distilled water, 30 %, 40 % and 50 % alcohol (3.20 g / Kg body weight). Five rats from each group were sacrificed at the end of 1, 7, 14, 21, and 28 day(s) of the experiment. Assay of glutathione

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Huang, Shan, and Hanying Zhao. "Thiol‐dithioester reaction: An approach to the end‐group removal and end‐functionalization of RAFT‐synthesized polymers." Journal of Polymer Science 62, no. 24 (2024): 5598–608. https://doi.org/10.1002/pol.20240501.

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AbstractReversible addition−fragmentation chain transfer (RAFT) polymerization has been one of the most versatile methods in the synthesis of well‐defined polymers. The stability of the thiocarbonylthio chain transfer agents (CTAs) in the polymerization and the removal of CTAs after the polymerization are the two great concerns for the applications of RAFT polymerization. In this research, thiol‐dithioester reaction under the catalysis of triethylamine (TEA) is studied. In a model reaction, thiolate anion has nucleophilic addition reaction with dithioester compound, resulting in the synthesis

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Mikhalchik, E. V., I. V. Borodina, I. V. Vlasova, et al. "Biomarkers of system inflammation in local and diffuse peritonitis." Biomeditsinskaya Khimiya 66, no. 5 (2020): 411–18. http://dx.doi.org/10.18097/pbmc20206605411.

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In cases of any acute surgical abdominal disease the progression of purulent inflammation can lead to local or diffuse peritonitis. The indicators of the degree and specificity of the inflammatory response in blood such as cytokine concentration, neutrophil activity, plasma antioxidant capacity (thiols concentration) could be considered as potential predictors of complications. The luminol-dependent chemiluminescence (CL) response of blood activated by the phorbol ester (PMA), and the concentration of cytokines IL-6, IL-8, IL-10, myeloperoxidase (MPO) and thiols in plasma were measured in pati

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Antalík, Marián, Ernest Šturdík, Dušan Podhradský, Ingrid Poleková, and Ľudovít Drobnica. "Kinetics analysis of the decay of phenylhydrazonopropanedinitrile addition products with thiols in aqueous solutions." Collection of Czechoslovak Chemical Communications 54, no. 12 (1989): 3387–96. http://dx.doi.org/10.1135/cccc19893387.

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The reactions of phenylhydrazonopropanedinitriles with thiols are reversible and with increasing pH-values of aqueous solutions the equilibrium is shifted them to the side of the reactants. A mechanism of the decay of corresponding addition products was proposed and the kinetic description based on this mechanism is in good agreement with the obtained experimental data. From the viewpoint of the decay, the pH-dependent dissociation of the proton of the imino group formed by addition of thiol to the nitrile carbon atom plays a decisive role. The obtained knowledge is useful with respect to the

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Pfaff, Annalise R., Justin Beltz, Emily King, and Nuran Ercal. "Medicinal Thiols: Current Status and New Perspectives." Mini-Reviews in Medicinal Chemistry 20, no. 6 (2020): 513–29. http://dx.doi.org/10.2174/1389557519666191119144100.

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The thiol (-SH) functional group is found in a number of drug compounds and confers a unique combination of useful properties. Thiol-containing drugs can reduce radicals and other toxic electrophiles, restore cellular thiol pools, and form stable complexes with heavy metals such as lead, arsenic, and copper. Thus, thiols can treat a variety of conditions by serving as radical scavengers, GSH prodrugs, or metal chelators. Many of the compounds discussed here have been in use for decades, yet continued exploration of their properties has yielded new understanding in recent years, which can be us

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Emre, Birten, Ömer Korkmaz, Ismail Koyuncu, et al. "Determination of thiol/disulphide homeostasis as a new indicator of oxidative stress in dairy cows with subclinical endometritis." Veterinarski arhiv 91, no. 2 (2021): 137–48. http://dx.doi.org/10.24099/vet.arhiv.0914.

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The objective of this study was to determine thiol/disulphide homeostasis (TDH) in infertile cows with subclinical endometritis (SCE). Endometrial cytological samples were collected using a cytobrush to diagnose SCE in 36 infertile cows. According to the results of the cytology examination, those with acute endometritis were classified as Group I (n = 20) and those with chronic endometritis were classified as Group II (n = 16). A control group was formed of heifers as Group III (n = 20). Blood samples were taken from each group on the day of diagnosis (day 0) to analyse TDH. In the cytology ex

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Zhong, Chao, Krisztina Zajki-Zechmeister, and Bernd Nidetzky. "Reducing end thiol-modified nanocellulose: Bottom-up enzymatic synthesis and use for templated assembly of silver nanoparticles into biocidal composite material." Carbohydrate Polymers 260 (February 11, 2021): 117772. https://doi.org/10.1016/j.carbpol.2021.117772.

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<strong>Abstract</strong> Nanoparticle-polymer composites are important functional materials but structural control of their assembly is challenging. Owing to its crystalline internal structure and tunable nanoscale morphology, cellulose is promising polymer scaffold for templating such composite materials. Here, we show bottom-up synthesis of reducing end thiol-modified cellulose chains by iterative bi-enzymatic β-1,4-glycosylation of 1-thio-β-D-glucose (10 mM), to a degree of polymerization of &sim;8 and in a yield of &sim;41% on the donor substrate (α-D-glucose 1-phosphate,

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Celik, Esra, Seyithan Taysi, Seyhun Sucu, Hasan Ulusal, Emin Sevincler, and Ahmet Celik. "Urotensin 2 and Oxidative Stress Levels in Maternal Serum in Pregnancies Complicated by Intrauterine Growth Restriction." Medicina 55, no. 7 (2019): 328. http://dx.doi.org/10.3390/medicina55070328.

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Background and objectives: In this study, the aim was to investigate Urotensin 2 (U-II) levels and oxidant/antioxidant system parameters in pregnancies with intrauterine growth restriction (IUGR). Materials and Methods: A total of 36 healthy, pregnant women who had not been diagnosed with IUGR and 36 pregnant women who had been diagnosed with IUGR at the Obstetrics and Gynecology Outpatient Clinic at Gaziantep University Hospital were enrolled in this study. The serum total antioxidant status (TAS), total oxidant status (TOS), thiol-disulfide levels, U-II measurements, and oxidative stress ind

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Calhoun, M. C., B. C. Baldwin, S. W. Kuhlmann, and H. L. Kim. "Experimental prevention of bitterweed (Hymenoxys odorata) poisoning of sheep." American Journal of Veterinary Research 50, no. 9 (1989): 1642–46. https://doi.org/10.2460/ajvr.1989.50.09.1642.

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SUMMARY To examine the effects on bitterweed toxicity of dietary factors known to increase thiol concentrations in the body, 36 lambs were fed one of the following diets (12 lambs/diet) for a minimum of 9 days prior to bitterweed administration: diet 1, 10% crude protein; diet 2, 20% crude protein, 0.5% methionine, 0.5% sodium sulfate, and 1,102 IU of vitamin E/kg; and diet 3, diet 2 with 0.5% ethoxyquin hydrochloride added. Four lambs fed each diet were euthanatized prior to bitterweed administration (initial euthanasia group). Four lambs fed each diet were administered bitterweed (0.68% hyme

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Xie, Zhenzhen, Mandapati V. Ramakrishnam Raju, Prasadanie K. Adhihetty, Xiao-An Fu, and Michael H. Nantz. "Effect of Thiol Molecular Structure on the Sensitivity of Gold Nanoparticle-Based Chemiresistors toward Carbonyl Compounds." Sensors 20, no. 24 (2020): 7024. http://dx.doi.org/10.3390/s20247024.

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Increasing both the sensitivity and selectivity of thiol-functionalized gold nanoparticle chemiresistors remains a challenging issue in the quest to develop real-time gas sensors. The effects of thiol molecular structure on such sensor properties are not well understood. This study investigates the effects of steric as well as electronic effects in a panel of substituted thiol-urea compounds on the sensing properties of thiolate monolayer-protected gold nanoparticle chemiresistors. Three series of urea-substituted thiols with different peripheral end groups were synthesized for the study and u

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Yin, Yue, Jung Lee, Nak Kim, et al. "Inhibition of Tumor Growth via Systemic siRNA Delivery Using Reducible Bile Acid-Conjugated Polyethylenimine." Polymers 10, no. 9 (2018): 953. http://dx.doi.org/10.3390/polym10090953.

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RNA interference (RNAi), mediated by small interfering RNA (siRNA), has been considered as a potential therapeutic agent for cancer owing to its ability to suppress target genes in a sequence-specific manner. In this study, a conjugate of the low molecular weight (MW) polyethylenimine (PEI) (MW 1800) and deoxycholic acid (DA) was further modified with 4-fluorothiophenol (FTP) (TP-DA-PEI) to achieve systemic siRNA delivery. The thiophenol group would be involved with disulfide bonds between the polymer chains and siRNA modified with free thiols (thiol-siRNA) to form and π–π interactions between

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