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Journal articles on the topic 'Thiopyrimidines'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Coulibali, Siomenan, Souleymane Coulibaly, Patrick-Armand Achi, Kouassi Yves Guillaume Sissouma Drissa Molou, and Ané Adjou. "Synthesis of New Thiazolopyrimidines and 2-Alkylthiopyrimidines Derivatives." Pharmaceutical and Chemical Journal 9, no. 1 (2022): 5–10. https://doi.org/10.5281/zenodo.13970008.

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In this work, we reported the synthesis of derivative’s 2-thiopyrimidine substituted on the positions -1 and -2 by the alkyl groups. The bicyclic scaffold (<strong>6a</strong> and <strong>6b</strong>) were obtained via condensation of 2-thiopyrimidines (<strong>4a</strong> and <strong>4b</strong>) with dihalogenated ethane <strong>5</strong> in the presence of potassium carbonate<strong>.</strong> We got the 2-thioalkylpyrimidine derivatives (<strong>8a</strong>-<strong>f</strong>) with the same workup, condensing halogenated alkyls <strong>7</strong> with 2-thiopyrimidines (<strong>4a</

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2

Sharma, Dolly, Vinit Kumar, and Reshma Rani. "Design, synthesis, in silico ADME/T profiling of pseudo-pyrimidine derivatives and anticancer activity evaluation." Research Journal of Chemistry and Environment 26, no. 8 (2022): 30–37. http://dx.doi.org/10.25303/2608rjce30037.

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Pyrimidines are aromatic heterocyclic nitrogenous bases predominantly present as integral building blocks of DNA and RNA. The alternating single and double bonds connecting the C and N atoms in these 6-membered heterocyclic rings confer them to resonance, aromaticity and exceptional stability. The prevalence of pyrimidine derivatives in nucleic acids, vitamins, amino acids, antibiotics, alkaloids and several reported bioactive compounds promoted investigation of their novel biological roles which eventually demonstrated a plethora of medicinal advantages of the pyrimidine scaffold by virtue of

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3

Vendrell-Criado, Victoria, Jose A. Sáez, Virginie Lhiaubet-Vallet, M. Consuelo Cuquerella, and Miguel A. Miranda. "Photophysical properties of 5-substituted 2-thiopyrimidines." Photochemical & Photobiological Sciences 12, no. 8 (2013): 1460. http://dx.doi.org/10.1039/c3pp50058f.

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4

Salieva, Gulrukh, Malokhat Uktamova, Kohei Torikai, and Tursunali Kholikov. "2-(Heptylthio)pyrimidine-4,6-diamine." Molbank 2025, no. 1 (2025): M1965. https://doi.org/10.3390/m1965.

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Thiopyrimidines represent one of the most active classes of compounds, possessing a wide spectrum of biological activities. Herein, we report the synthesis of 2-(heptylthio)pyrimidine-4,6-diamine (HPDA) via S-alkylation. The structure of HPDA was elucidated using 1H and 13C nuclear magnetic resonance (NMR), heteronuclear multiple bond correlation (HMBC), high resolution mass (HRMS), and infrared (IR) spectroscopies.

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5

Wanare, Rajendra Krushnaji. "A Novel and Facile Synthesis of Thiopyrimidines and O-Glucosides." Asian Journal of Organic & Medicinal Chemistry 4, no. 2 (2019): 65–69. http://dx.doi.org/10.14233/ajomc.2019.ajomc-p161.

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Reaction of 3-methyl-5-(3'-aryl prop-2'-enoyl)-1,2-benzisoxazole (1a-j) with thiourea and alcoholic solution of KOH afforded 3-methyl-5-(4'-aryl-2'-thiopyrimidin-6'-yl)-1,2-benzisoxazoles (2a-j). Oxidation of products 2a-j using alkaline KMnO4 solution produces 5-(4'-aryl-2'-thiopyrimidin-6'-yl)-1,2-benzisoxazole-3-carboxylic acids (3a-j). Condensation of products 3a-j with 2,3,4,6-tetra-Oacetyl-α-D-glucopyranosyl bromide (TAGBr), the glucosylating agent synthesized 3-(2,3,4,6-tetra-O-acetyl-3-acetyl-β-D-glucopyranosyl)-5-(4'-aryl-2'-thiopyrimidin-6'-yl)-1,2-benzisoxazoles (4a-j). Subsequent d

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6

Hammerland, Lance G., Martin Johansson, Jonas Malmström, et al. "Structure–activity relationship of thiopyrimidines as mGluR5 antagonists." Bioorganic & Medicinal Chemistry Letters 16, no. 9 (2006): 2467–69. http://dx.doi.org/10.1016/j.bmcl.2006.01.100.

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7

Sánchez, M. P. Sánchez, J. M. Salas Peregrin, M. A. Romero Molina, E. Colacio Rodríguez, and M. Moreno Carretero. "Thermal studies on metal complexes of 2-thiopyrimidines." Thermochimica Acta 93 (September 1985): 77–80. http://dx.doi.org/10.1016/0040-6031(85)85020-6.

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8

Simenel, Alexander A., Galina A. Dokuchaeva, Lubov' V. Snegur, et al. "Ferrocene-modified thiopyrimidines: synthesis, enantiomeric resolution, antitumor activity." Applied Organometallic Chemistry 25, no. 1 (2010): 70–75. http://dx.doi.org/10.1002/aoc.1691.

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9

S, A. MORKHADE, and N. INGLE V. "Synthesis of a few New 2'-Hydroxy-2-benzoyl-3- arylacrylophenones, 3-Benzoyl-2-arylchromones and 5-Benzoyl-1 ,2-dihydro-4-(2-hydroxyphenyl)- 6-aryl-2-thiopyrimidines." Journal of Indian Chemical Society Vol. 66, JAN 1989 (1989): 37–38. https://doi.org/10.5281/zenodo.5948117.

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Department of Chemistry, Nagpur University, Nagpur- 440010 <em>Manuscript received 1 June 1987, revised 27 July 1988, accepted 23 September 1988</em> 2<em>'</em>-Hydroxy-2-benzoyl-3-arylacrylophenones (2) have been prepared by the condensation of appropriate <strong>. </strong>β-diketone (1) and aromatic aldehyde. The acrylophenones thus obtained were oxidised with SeO<sub>2</sub>, to get the respective 3-benzoyl-2-arylchromones (3). These on reaction with thiourea gave 5-benzoyl-1,2-dihydro-4-(2-hydroxyphenyl)-6- aryl-2-thlopyridines (4). The identification of these compounds ha

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10

Metwally, M. A., E. Abdel-Galil, F. A. Amer, and A. M. Abdallah. "New Thiazolidinones, Thiazolines and Thiopyrimidines from 3,5-Diphenylcyclohex-2-enone." American Journal of Organic Chemistry 2, no. 1 (2012): 28–34. http://dx.doi.org/10.5923/j.ajoc.20120201.06.

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11

Sahoo, Biswa Mohan, B. V. V. Ravi Kumar, Jnyanaranjan Panda, and S. C. Dinda. "Ecofriendly and Facile One-Pot Multicomponent Synthesis of Thiopyrimidines under Microwave Irradiation." Journal of Nanoparticles 2013 (April 8, 2013): 1–6. http://dx.doi.org/10.1155/2013/780786.

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A rapid, improved, and ecofriendly synthesis of thiopyrimidines is carried out via one-pot multicomponent reaction of ethylcyanoacetate, substituted benzaldehydes, and thiourea in presence of ethanolic K2CO3 using microwave irradiation heating method. Excellent yields, shorter reaction time, and easy workup are the major advantageous features of this green protocol. So the application of multicomponent reactions involves the combination of multiple starting materials with different functional groups leading to the highly efficient and environmentally friendly construction of multifunctional dr

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12

Harnden, MR, and DT Hurst. "The Chemistry of Pyrimidinethiols. III. The Synthesis of Some Substituted Pyrimidinthiols and Some Thiazolo[5,4-D]pyrimidines." Australian Journal of Chemistry 43, no. 1 (1990): 55. http://dx.doi.org/10.1071/ch9900055.

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The preparation of a number of pyrimidinethiols and (substituted) thiopyrimidines has been carried out. The reaction of 5-acetylamino-2-aminopyrimidine-4,6-diol with phosphorus penta -sulfide in pyridine gave 5-amino-2-methylthiazolo[5,4-d]pyrimidine-7-thiol which was used to prepare several additional novel pyrimidine derivatives. Hydrolysis of the 4-carboxymethylthio derivative by using 5M hydrochloric acid gave 2,5-diamino-6-mercaptopyrimidin-4-ol hy -drochloride whilst hydrolysis of 2-methyl-7-methylthiothiazolo[5,4-d]pyrimidin-5-amine gave the corresponding 4-hydroxy derivative. Several 4

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13

T. Hurst, Derek, and Matthew Johnson. "The Synthesis and Aminolysis of Some 4-Chloro-2-(substituted) Thiopyrimidines." HETEROCYCLES 23, no. 3 (1985): 611. http://dx.doi.org/10.3987/r-1985-03-0611.

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14

Brem, Reto, Xiaohui Zhang, Yao-Zhong Xu, and Peter Karran. "UVA photoactivation of DNA containing halogenated thiopyrimidines induces cytotoxic DNA lesions." Journal of Photochemistry and Photobiology B: Biology 145 (April 2015): 1–10. http://dx.doi.org/10.1016/j.jphotobiol.2015.02.012.

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15

Karpenko, Yu V., O. I. Panasenko, S. M. Kulish, and A. V. Domnich. "Synthesis and acute toxicity of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl) thiopyrimidines." Current issues in pharmacy and medicine: science and practice 16, no. 2 (2023): 158–64. http://dx.doi.org/10.14739/2409-2932.2023.2.274586.

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In the literature, there is insufficient information on the synthesis of compounds in a series of pyrimidine-2-thiol derivatives containing a five-membered nitrogen-containing heterocyclic fragment; at the same time, there are a sufficient number of examples, demonstrating the synthetic and biological potential for compounds of this kind. The relevance of the study “structure – acute toxicity” relationship in a number of newly synthesized derivatives of 1,2,4-triazole-3(2H)-thione with pyrimidine-2-thiol is due to the synthesis of potential low molecular weight interferon inducers and antitumo

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16

Mistry, Prashant T., Nimesh R. Kamdar, Dhaval D. Haveliwala, and Saurabh K. Patel. "Succinct and Facile Synthesis of Innovative Thiopyrimidines With Antimicrobial and Antitubercular Investigation." Phosphorus, Sulfur, and Silicon and the Related Elements 188, no. 5 (2013): 561–72. http://dx.doi.org/10.1080/10426507.2012.692130.

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17

Heravi, Majid M., Navabeh Nami, Nasim Seifi, Hossein A. Oskooie, and Rahim Hekmatshoar. "Microwave-Assisted Synthesis of Substituted Pyrazoles and Pyrazolo [3, 4-d]thiopyrimidines." Phosphorus, Sulfur, and Silicon and the Related Elements 181, no. 3 (2006): 591–99. http://dx.doi.org/10.1080/10426500500269646.

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18

Haveliwala, Dhaval D., Nimesh R. Kamdar, Prashant T. Mistry, and Saurabh K. Patel. "Synthesis of novel thiopyrimidines: an investigation of anti-tubercular and antimicrobial activity." Journal of Sulfur Chemistry 32, no. 5 (2011): 451–62. http://dx.doi.org/10.1080/17415993.2010.523894.

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19

M., R. Patel, D. Akbari J., H. Purohit D., and S. Joshi H. "Synthesis and evaluation of pharmacological activity of some new aminopyrimidine and thiopyrimidine derivatives." Journal of Indian Chemical Society Vol. 84, Nov 2007 (2007): 1169–73. https://doi.org/10.5281/zenodo.5824805.

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Department of Chemistry, Saurashtra University, Rajkot-360 005, Gujarat, India <em>E-mail </em>: drhsjoshi@yahoo.com <em>Manuscript received 15 January 2007, revised 6 June 2007, accepted 17 August 2007</em> Various 3-(2-amino-6-arylpyrimidin-4-yl)-6-chlorocinnolin-4(3<em>H)</em>-one (2a-j) and 6-chloro-3-(6-aryl-2-mercapto3,4-dihydropyrimidin-4-yl)cinnolin-4(3<em>H</em>)-one (3a-j) were synthesized by the reaction of 6-chloro-3-[(2<em>E</em>)-3-arylprop-2-enoyl]- cinnolin-4(3<em>H</em>)-ones (1a-j) with guanidine hydrochloride and thiourea respectively. All newly synthesized compounds were te

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20

Liu, Guocheng, Jiaxi Xu, Ki Chul Park, et al. "Novel synthesis approach and antiplatelet activity evaluation of 6-alkylamino-2,4-dialkyl(aryl)thiopyrimidines." Tetrahedron 67, no. 29 (2011): 5156–61. http://dx.doi.org/10.1016/j.tet.2011.05.056.

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21

RAM, V. J., A. KAPIL, and P. Y. GURU. "ChemInform Abstract: Chemotherapeutic Agents. Part 20. Antileishmanial and Immunoadjuvant Activities of Rationally Designed Thiopyrimidines." ChemInform 22, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.199122163.

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22

Abdel‐Mohsen, Heba T., Adel S. Girgis, Abeer E. E. Mahmoud, Mamdouh M. Ali, and Hoda I. El Diwani. "New 2,4‐disubstituted‐2‐thiopyrimidines as VEGFR‐2 inhibitors: Design, synthesis, and biological evaluation." Archiv der Pharmazie 352, no. 11 (2019): 1900089. http://dx.doi.org/10.1002/ardp.201900089.

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23

El‐serwy, Walaa S., Hanaa S. Mohamed, Weam S. El‐serwy, et al. "Molecular Docking Study of Newly Synthesized Thiopyrimidines as Antimicrobial Agents Targeting DNA Gyrase Enzyme." Journal of Heterocyclic Chemistry 56, no. 7 (2019): 2027–35. http://dx.doi.org/10.1002/jhet.3583.

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24

Armand Patrick ACHI, Doumadé ZON, Adéyolé TIMOTOU, Evrard ABLO, Claude Landry Ahmont KABLAN, and Siomenan COULIBALI. "Study of the influence of N-alkylation of 2-benzylthiopyrimidines on the growth of two bacteria of medical interest." GSC Advanced Research and Reviews 12, no. 3 (2022): 018–25. http://dx.doi.org/10.30574/gscarr.2022.12.3.0230.

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The present work highlights the synthesis and effect of introducing substituents on the nitrogen at position -1 of five 2-benzylthiopyrimidine derivatives (6a-e). The compounds (6a-e) were obtained by condensation of 2-thiopyrimidines (4) with benzyl halides in the presence of a base. As for the N-alkylated/arylated-2thiobenzylpyrimidines (8a-k), they were obtained by nucleophilic substitution reaction on nitrogen in basic medium. All the synthesized compounds were characterized by 1H proton, 13C carbon NMR spectroscopic analyses and high resolution mass spectrometry. All compounds were subjec

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25

Abd El Salam, Hayam A., El-Sayed M. A. Yakout, M. A. El-Hashash, and Galal A. M. Nawwar. "Facile synthesis of 6-(heptadec-8-enyl)thiopyrimidines incorporating glycosyl moiety and their antitumor activity." Monatshefte für Chemie - Chemical Monthly 144, no. 12 (2013): 1893–901. http://dx.doi.org/10.1007/s00706-013-1069-5.

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26

Abdel-Mohsen, Heba T., Mohamed A. Omar, Ahmed M. El Kerdawy, Abeer E. E. Mahmoud, Mamdouh M. Ali, and Hoda I. El Diwani. "Novel potent substituted 4-amino-2-thiopyrimidines as dual VEGFR-2 and BRAF kinase inhibitors." European Journal of Medicinal Chemistry 179 (October 2019): 707–22. http://dx.doi.org/10.1016/j.ejmech.2019.06.063.

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27

Armand, Patrick ACHI, ZON Doumadé, TIMOTOU Adéyolé, ABLO Evrard, Landry Ahmont KABLAN Claude, and COULIBALI Siomenan. "Study of the influence of N-alkylation of 2-benzylthiopyrimidines on the growth of two bacteria of medical interest." GSC Advanced Research and Reviews 12, no. 3 (2022): 018–25. https://doi.org/10.5281/zenodo.7171872.

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The present work highlights the synthesis and effect of introducing substituents on the nitrogen at position -1 of five 2-benzylthiopyrimidine derivatives (6a-e). The compounds (6a-e) were obtained by condensation of 2-thiopyrimidines (4) with benzyl halides in the presence of a base. As for the N-alkylated/arylated-2thiobenzylpyrimidines (8a-k), they were obtained by nucleophilic substitution reaction on nitrogen in basic medium. All the synthesized compounds were characterized by 1H proton, 13C carbon NMR spectroscopic analyses and high resolution mass spectrometry. All compounds were subjec

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28

Kim, Hea Ok, Yong Hee Park, Hyung Ryong Moon, and Lak Shin Jeong. "Synthesis and Biological Evaluation of Novel d-2′-Azido-2′,3′-dideoxyarabinofuranosyl-4′-thiopyrimidines and purines." Bioorganic & Medicinal Chemistry Letters 12, no. 17 (2002): 2403–6. http://dx.doi.org/10.1016/s0960-894x(02)00394-3.

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29

Liu, Guocheng, Jiaxi Xu, Ki Chul Park, et al. "ChemInform Abstract: Novel Synthesis Approach and Antiplatelet Activity Evaluation of 6-Alkylamino-2,4-dialkyl(aryl)thiopyrimidines." ChemInform 42, no. 47 (2011): no. http://dx.doi.org/10.1002/chin.201147152.

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30

Sánchez-Sánchez, M. P., J. M. Salas-Peregrín, M. A. Romero-Molina, and A. Mata-Arjona. "Stability and thermodynamic parameters of thiopyrimidines, 2-thioxanthine and their complexes with Zn(II) and Cd(II)." Thermochimica Acta 88, no. 2 (1985): 355–61. http://dx.doi.org/10.1016/0040-6031(85)85455-1.

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31

Abd El Salam, Hayam A., El-Sayed M. A. Yakout, M. A. El-Hashash, and Galal A. M. Nawwar. "ChemInform Abstract: Facile Synthesis of 6-(Heptadec-8-enyl)thiopyrimidines Incorporating Glycosyl Moiety and Their Antitumor Activity." ChemInform 45, no. 16 (2014): no. http://dx.doi.org/10.1002/chin.201416228.

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32

Karpenko, Yu V., O. I. Panasenko, and A. P. Litun. "Search for molecular descriptors and computer prediction of biological activity in a series of S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines." Current issues in pharmacy and medicine: science and practice 17, no. 1 (2024): 5–9. http://dx.doi.org/10.14739/2409-2932.2024.1.298027.

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Most pharmaceutical compounds interact with various molecular compositions in the body, leading to complex biological effects. Furthermore, during biotransformation, they may generate one or more metabolites with potent bioactive properties. Therefore, the development and careful use of new medications require thorough examination of their biological impact profiles, including considerations of human metabolic processes. In silico techniques are currently widely used to evaluate the interactions of emerging drug candidates with pharmacological conditions and predict their metabolic conversions

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33

Karpenko, Yu V., and O. I. Panasenko. "Search for antibacterial activity in a number of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines." Current issues in pharmacy and medicine: science and practice 14, no. 2 (2021): 173–78. http://dx.doi.org/10.14739/2409-2932.2021.2.234565.

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The relevance of the study of 1,2,4-triazole derivatives with pyrimidine fragment is due to the synthesis of potential broad-spectrum antibacterial drugs, low molecular weight inducers of interferon, and antitumor agents, search for molecular descriptors of their structure, important for establishing patterns “structure – biological activity”. The aim of the work is a computer search for the antibacterial action of new hybrids of 1,2,4-triazole-3(2H)-thiol with a pyrimidine fragment in relation to 5 test cultures, to establish the dependence of “structure – action”. Materials and methods. For

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34

Kim, Hea Ok, Yun Ha Kim, Hwal Suh, and Lak Shin Jeong. "Synthesis and antiviral activity of novel d- and l-2′-azido-2′,3′-dideoxyribofuranosyl-4′-thiopyrimidines and purines." Bioorganic & Medicinal Chemistry Letters 11, no. 4 (2001): 599–603. http://dx.doi.org/10.1016/s0960-894x(01)00006-3.

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35

Kim, Hea Ok, Yong Hee Park, Hyung Ryong Moon, and Lak Shin Jeong. "ChemInform Abstract: Synthesis and Biological Evaluation of Novel D-2′-Azido-2′,3′-dideoxyarabinofuranosyl-4′-thiopyrimidines and Purines." ChemInform 33, no. 51 (2010): no. http://dx.doi.org/10.1002/chin.200251201.

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36

Azev, Yu A., T. Duelcks, and E. Lork. "Synthesis and properties of 5-nitropyrimidine derivatives: Features of the structure and chemical transformations of boron-containing thiopyrimidines." Pharmaceutical Chemistry Journal 41, no. 9 (2007): 495–501. http://dx.doi.org/10.1007/s11094-007-0111-5.

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M., J. Ladani, D. Tala S., D. Akbari J., F. Dhaduk M. та S. Joshi H. "Synthesis and biological study of oxopyrimidines and thiopyrimidines of 2-(2,4-dichlorophenyl)imidazo[1,2-α ]pyridin-3-carbaldehyde". Journal of Indian Chemical Society Vol. 86, Jan 2009 (2009): 104–8. https://doi.org/10.5281/zenodo.5807328.

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Department of Chemistry, Saurashtra University, Rajkot-360 005, Gujarat, India <em>E-mail</em> : drhsjoshi49@gmail.com <em>Manuscript received 14 November 2007, revised 6 August 2008, accepted 17 September 2008</em> 2-(2,4-Dichlorophenyl)imidazo[1,2-α]pyridlne-3·carbaldehyde (1) was prepared from 2-aminopyridine through multi-step reaction. Compound 1 reacts with different aryl ketones in the presence of catalytic amount of 40% KOH to give (2<em>E</em>)-3-[2-(2,4-dichlorophenyl)imidazo[1,2-α]pyridin-3-yl]-1-arylprop-2-en-1-ones (2a-j), which on cyclization with urea and

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Chate, Asha, та Charansingh Gill. "β-Cyclodextrin (β-CD) as a Supramolecular Catalyst for the Synthesis of Isoxazoles and Thiopyrimidines and their Antimicrobial Screening". Letters in Organic Chemistry 14, № 2 (2017): 93–102. http://dx.doi.org/10.2174/1570178614666161230124807.

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39

Kim, Hea Ok, Yun Ha Kim, Hwal Suh, and Lak Shin Jeong. "ChemInform Abstract: Synthesis and Antiviral Activity of Novel D- and L-2′-Azido-2′,3′-dideoxyribofuranosyl-4′-thiopyrimidines and Purines." ChemInform 32, no. 26 (2010): no. http://dx.doi.org/10.1002/chin.200126211.

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40

Karpenko, Yuriy, Kateryna Medvedeva, Andrii Solomennyi, et al. "Design, synthesis, molecular docking, and antioxidant properties of a series of new S-derivatives of ((1,2,4-triazol-3(2H)-yl)methyl)thiopyrimidines." ScienceRise: Pharmaceutical Science, no. 1 (53) (February 28, 2025): 62–70. https://doi.org/10.15587/2519-4852.2025.312075.

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The aim of our work is to synthesize new S-derivatives in the series of ((1,2,4-triazol-3(2H)-yl)methyl)thiopyrimidines and to study their antioxidant activity, to identify the most promising compound using molecular docking and kinetic parameters. Materials and methods. The 1H and 13C NMR spectra were recorded on a Bruker AC-500 spectrometer. LC-MS was recorded on an Agilent 1260 Infinity HPLC system equipped with a diode-array detector and proton ionization. Elemental analysis (C, H, N, S) was performed on an ELEMENTAR vario EL cube. Molecular docking was performed using the AutoDock 4.2.6 p

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41

Louvel, Julien, Dong Guo, Marta Agliardi, et al. "Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines." Journal of Medicinal Chemistry 57, no. 8 (2014): 3213–22. http://dx.doi.org/10.1021/jm401643m.

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42

Ali, Islam H., Heba T. Abdel-Mohsen, Marwa M. Mounier, Mahmoud T. Abo-elfadl, Ahmed M. El Kerdawy, and Iman A. Y. Ghannam. "Design, synthesis and anticancer activity of novel 2-arylbenzimidazole/2-thiopyrimidines and 2-thioquinazolin-4(3H)-ones conjugates as targeted RAF and VEGFR-2 kinases inhibitors." Bioorganic Chemistry 126 (September 2022): 105883. http://dx.doi.org/10.1016/j.bioorg.2022.105883.

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43

Bakari, Souad, Marco Borsari, Maria Cannio, et al. "Role of the solvent in the oxidative process of a Hg electrode in the presence of thiopyrimidine derivatives." Canadian Journal of Chemistry 83, no. 8 (2005): 1132–36. http://dx.doi.org/10.1139/v05-125.

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The electrochemical oxidation of a Hg electrode in the presence of thiopyrimidine derivatives has been investigated in a collection of organic solvents using voltammetric and polarographic techniques. Remarkable adsorption phenomena control the electrochemical process, which in all cases gives rise to a Hg(I) complex. The Laviron adsorption model is found to describe well the polarographic adsorption wave. Some correlations between adsorption parameters and solvent properties have also been observed and discussed.Key words: polarography, voltammetry, thiopyrimidine, solvent effect, adsorption.

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Gutiérrez, M. D., R. López, M. A. Romero, and J. M. Salas. "Spectroscopic studies of some Pd(II), Pt(II), Ag(I), and Au(III) complexes of 4,6-diamino-2-thiopyrimidine and 4,6-diamino-2-methylthiopyrimidine. Structure and binding site determination." Canadian Journal of Chemistry 66, no. 2 (1988): 249–55. http://dx.doi.org/10.1139/v88-042.

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Interaction of Pd(II), Pt(II), Ag(I), and Au(III) with 4,6-diamino-2-thiopyrimidine (DATP) and 4,6-diamino-2-methyl-thiopyrimidine (DAMTP) in aqueous medium resulted in the formation of new complexes which have been characterized by elemental analysis, ir, 1H-nmr spectroscopic techniques, magnetic susceptibility measurements in the solid state, and conductivity measurements in DMF solution. The ir and 1H-nmr spectra were consistent with coordination involving the non-protonated ring nitrogen atom, the exocyclic sulphur atom, or N,S-chelation.

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Zou, Xiaoran, Zhonghua Sun, Hongmei Zhao, and Chun-yang Zhang. "Mechanistic insight into photocrosslinking reaction between triplet state 4-thiopyrimidine and thymine." Physical Chemistry Chemical Physics 21, no. 38 (2019): 21305–16. http://dx.doi.org/10.1039/c9cp04089g.

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46

Shamroukh, A. H., H. A. Soliman, I. S. Abd-Elsalam, A. M. Saleh, A. A. El-Rashedy, and M. I. Hegab. "Synthesis, Antioxidant, Antimicrobial, and Molecular Docking Evaluation of Some Newly 2-Thiopyrimidines and Thiopyrans Using 1-Cyclohexyl-3-(4-substituted-phenyl)prop-2-en-1-ones as Precursors." Russian Journal of General Chemistry 94, no. 10 (2024): 2743–58. http://dx.doi.org/10.1134/s1070363224100190.

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ALl, A. EL-BARDAN, A. HAMED EZZAT, L. ABOUL-ELA SALAH, and M. MOUSSA ADEL. "Synthesis and Spectral Studies of some Novel Thiobenzimidazole, Thiopurine and Thiopyrimidine Derivatives." Journal of Indian Chemical Society Vol. 74, Jul 1997 (1997): 575–78. https://doi.org/10.5281/zenodo.5908807.

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Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt <em>Manuscript received 3 April 1996, accepted 21 May 1996</em> Synthesis and Spectral Studies of some Novel Thiobenzimidazole, Thiopurine and Thiopyrimidine Derivatives.

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Sipyagin, A. M., and V. S. Enshov. "Perfluoroalkylation of 2-Thiopyrimidine Derivatives." Chemistry of Heterocyclic Compounds 39, no. 9 (2003): 1172–77. http://dx.doi.org/10.1023/b:cohc.0000008261.59363.c0.

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Shigeta, S., S. Mori, F. Watanabe, et al. "Synthesis and Antiherpesvirus Activities of 5-Alkyl-2-Thiopyrimidine Nucleoside Analogues." Antiviral Chemistry and Chemotherapy 13, no. 2 (2002): 67–82. http://dx.doi.org/10.1177/095632020201300201.

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Twenty 5-alkyl-2-thiopyrimidine nucleosides were newly synthesized and examined for antiviral activities against herpes simplex virus (HSV), varicella-zoster virus (VZV) and human cytomegalovirus (HCMV). In this study, 2′-deoxy-5- alkyl-2-thiocytidine analogues had lower 50% effective concentration (EC50) values against HSV- 1, and 2/-deoxy-5-alkyl-2-thiouridine analogues showed lower EC50 against VZV than their congeners of arabinoside form. Among the compounds examined, 2′-deoxy-5-ethyl and 5-propyl- 2-thiocytidine (TN-53 and TN-54) were most potent and selective anti-HSV compounds. Their EC

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Battistuzzi, R., M. Borsari, D. Dallari, G. Gavioli, C. Tavagnacco, and G. Costa. "Electrochemistry of 4,6-dimethyl-2-thiopyrimidine and 4,6-dimethyl-1-phenyl-2-thiopyrimidine in dimethylformamide." Journal of Electroanalytical Chemistry 368, no. 1-2 (1994): 227–34. http://dx.doi.org/10.1016/0022-0728(93)03075-z.

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