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Dissertations / Theses on the topic 'Thrombotic complications'

Author: Grafiati

Published: 15 June 2024

Last updated: 31 July 2025

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1

Tardy-Poncet, Brigitte. "Potential roles of TFPI in both thrombotic and hemorrhagic diseases." Thesis, Saint-Etienne, 2012. http://www.theses.fr/2012STET007T/document.

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L'inhibiteur de la Voie du Facteur Tissulaire (TFPI) est une protéine régulatrice de la coagulation plasmatique intervenant à la phase initiale de la cascade. Il inhibe en présence de la protéine S (PS) le facteur Xa et ce complexe TFPI-Xa inactive ensuite le complexe FT-VIIa. Nous avons recherché une résistance à l'activité anticoagulante du TFPI. La sensibilité du plasma à une quantité fixe de TFPI a été évaluée sur la base d'un temps de thromboplastine diluée (TTD) réalisé avec et sans TFPI : - chez des patients ayant présenté une thrombose veineuse profonde inexpliquée ; cette résistance s

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2

Moussa, Mouhamed Djahoum. "Déterminants cliniques, physiopathologiques et pronostics associés aux complications liées à l’hémostase au cours des assistances circulatoires de courte durée à pompe centrifuge." Electronic Thesis or Diss., Université de Lille (2022-....), 2022. http://www.theses.fr/2022ULILS055.

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La problématique de cette thèse est la caractérisation des complications liées à l’hémostase chez le patient assisté par ECMO-VA périphérique afin d’en améliorer la prévention et de rationaliser les approches antithrombotiques en usage. Dans une première étude, nous avons décrit qualitativement et quantitativement la composition des thrombi formés sur les circuits d’ECMO-VA. Nous avons observé que ces thrombi sont majoritairement composés de VWF, de fibrine et dans une moindre proportion de plaquettes et d’érythrocytes. Notre approche quantitative a également permis de mettre en évidence la pr

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3

Lapidus, Lasse. "Thromboembolism following orthopaedic surgery : outcome and diagnostic procedures after prophylaxis in lower limb injuries /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-111-1/.

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4

Smith, Sarah Faith. "Influences on the incidence of clinical deep vein thrombosis and pulmonary embolism in a prospectively collated population of 21,000 neurosurgical inpatients." Thesis, The University of Sydney, 2001. http://hdl.handle.net/2123/818.

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Records of all neurosurgical inpatients admitted to Royal North Shore Hospital since 1976 have been prospectively kept in a relational database. Demographic details, diagnoses, operations and complications have been entered continuously since 1982 by the author of this study. Complications are monitored at monthly review meetings attended by medical staff. The recurrence of deep vein thrombosis (DVT) and pulmonary embolism (PE) at these meetings, despite continual improvements in patient care, prompted this study. It aims to use the database to study changes in the incidence of DVT and PE

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5

Smith, Sarah Faith. "Influences on the incidence of clinical deep vein thrombosis and pulmonary embolism in a prospectively collated population of 21,000 neurosurgical inpatients." University of Sydney. Public Health and Community Medicine, 2001. http://hdl.handle.net/2123/818.

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Records of all neurosurgical inpatients admitted to Royal North Shore Hospital since 1976 have been prospectively kept in a relational database. Demographic details, diagnoses, operations and complications have been entered continuously since 1982 by the author of this study. Complications are monitored at monthly review meetings attended by medical staff. The recurrence of deep vein thrombosis (DVT) and pulmonary embolism (PE) at these meetings, despite continual improvements in patient care, prompted this study. It aims to use the database to study changes in the incidence of DVT and PE

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6

Ziaziaris, William Andrew. "Pediatric Liver Transplantation: Improvement in Outcomes." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16265.

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Introduction and Aims Although relatively uncommon in children, end-stage liver failure is a potentially devastating condition that occurs secondary to either a congenital anomaly causing cholestasis, metabolic disease (MTBD), neoplasia or fulminant hepatic failure (FHF). When this occurs, patients will likely require liver transplantation (LT). LT remains the gold-standard for children with end-stage liver failure despite high morbidity and mortality associated with the complex pathophysiology of liver failure, the procedure itself and subsequent lifelong immunosuppression. Surgical complica

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7

Matielo, Marcelo Fernando. "Incidência de trombose venosa profunda pós-operatória no membro amputado de pacientes com doença arterial oclusiva periférica." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-29012009-165529/.

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Introdução: Pacientes submetidos à amputação de membro inferior por doença arterial obstrutiva periférica (DAOP) estão em risco para o desenvolvimento de trombose venosa profunda (TVP). Há poucos estudos na literatura sobre a incidência no pós-operatório precoce e quanto aos fatores de risco no desenvolvimento da TVP no membro amputado. Objetivo: A finalidade deste estudo é avaliar, de modo prospectivo, a incidência de trombose venosa profunda pós-operatória em até 35 dias, em pacientes submetidos à amputação de membro inferior por doença arterial obstrutiva periférica, sua relação com comorbi

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8

Oliveira, Samantha Carlos de. "Trombocitopenia induzida por heparina: aspectos clínicos e laboratoriais." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-04112008-155406/.

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A trombocitopenia induzida por heparina (TIH) é uma síndrome imunohematológica mediada por um anticorpo que causa ativação plaquetária na presença de heparina, induz à agregação plaquetária e pode estar associada a graves e paradoxais complicações trombóticas e morte. A freqüência de TIH nos pacientes que recebem heparina por mais de cinco dias é de 1% a 5%, e está relacionada a vários fatores. Este é um estudo pioneiro no Brasil, que objetivou avaliar aqui a freqüência de TIH nos pacientes em uso de heparina, a relação ao gênero, ao tipo de heparina e a associação do genótipo da FcRIIa de rec

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9

Nilsson, Elin, and Linnéa Oskarsson. "Graderade kompressionsstrumpors preventiva effekt för djup ventrombos och posttrombotiskt syndrom." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-408302.

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Bakgrund: Djup ventrombos (DVT) är en allvarlig komplikation postoperativt och kan leda till ett livshotande tillstånd för patienten. Graderade kompressionsstrumpor (GCS) används på många postoperativa avdelningar tillsammans med andra profylaktiska åtgärder för att förebygga utvecklingen av DVT. Kompressionsstrumpor används även till att förebygga posttrombotiskt syndrom (PTS) efter en DVT. PTS kan utvecklas på grund av att de venösa klaffarna skadas vid en DVT, till följd stockar sig blodet och ödem bildas vilket leder till försämrad näring- och syretillförsel till vävnaderna. Syfte: Syftet

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10

Galanaud, Jean-Philippe. "Les thromboses veineuses méconnues des membres inferieurs : thromboses veineuses profondes distales et thromboses veineuses superficielles." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T027.

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Rationnel: Bien qu'elles constituent la majorité des thromboses veineuses des membres inférieurs, les thromboses veineuses profondes (TVP) distale et les thromboses veineuses superficielles (TVS) ont été peu étudiées et leur significativité clinique et leur prise en charge sont débattues.Méthodes: Cette thèse collige les résultats des travaux effectués par J.P. Galanaud sur les TVP distales et les TVS à partir des études épidémiologiques OPTIMEV, POST et RIETE.Résultats commentés: TVP distale: La TVP distale n'a pas le même profil de facteur de risque que la TVP proximale. Sa mortalité associé

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11

Linden, Matthew D. "The haemostatic defect of cardiopulmonary bypass." University of Western Australia. School of Surgery and Pathology, 2003. http://theses.library.uwa.edu.au/adt-WU2006.0009.

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[Truncated abstract] Cardiac surgery involving cardiopulmonary bypass is a complex procedure that results in significant changes to blood coagulation, fibrinolytic biochemistry, platelet number and function, and the vasculature. These are due to pharmacological agents which are administered, haemodilution and contact of the blood with artificial surfaces. Consequently there are significant risks of thrombosis and haemorrhage associated with this procedure. The research presented in this thesis utilises in vitro, in vivo, and a novel ex vivo model to investigate the nature of the haemostatic de

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12

Grebelis, Arimantas. "Pakartotinės operacijos po širdies vožtuvų protezavimo." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090611_130902-56448.

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Habilitacijos procedūrai teikiamoje mokslo darbų apžvalgoje apibendrinama Vilniaus universiteto Širdies ir kraujagyslių ligų klinikos Širdies chirurgijos centro patirtis, pakartotinai operuojant ligonius po širdies vožtuvų protezavimo. Įvertintas mažai trombogeniškų protezų efektyvumas. Nustatyta, kad labai sunkių ligonių su infekuotais protezais mirštamumas nemažėja, nors pastaraisiais metais daugiau operuojame III funkcinės klasės ligonių ir jų operacijų rezultatai puikūs. Dėl pasiūlyto radikalesnio triburio vožtuvo nesandarumo gydymo pirminių operacijų metu, efektyviai mažėja pakartotinių š

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13

Martí, Sáez Edelmira. "Trombofilia y embarazo." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/394038.

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INTRODUCCIÓN: La causa más importante de mortalidad materna en los países occidentales es la enfermedad tromboembólica venosa (ETEV). El embarazo es un estado de hipercoagulabilidad que predispone a la aparición de este tipo de complicaciones, aún más si existen otros factores de riesgo, como la trombofilia. La presencia de trombofilia también se ha relacionado en las últimas décadas con la aparición con otro tipo de complicaciones gestacionales aún más frecuentes: las llamadas complicaciones vasculares gestacionales (CVG), al parecer secundarias a una disfunción o insuficiencia placentaria.

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14

Silva, Katia Regina da. "Estudo clínico randomizado para profilaxia das complicações tromboembólicas pós-implante transvenoso de dispositivos cardíacos eletrônicos em pacientes de alto risco." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5156/tde-12092008-141236/.

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I ntrodução: A incidência de lesões venosas pós-implante transvenoso de dispositivos cardíacos eletrônicos implantáveis (DCEI) é elevada, sendo a disfunção ventricular e o uso prévio de marcapasso temporário (MPT) ipsilateral ao implante definitivo fatores de risco independentes para sua ocorrência. A utilidade de estratégias terapêuticas profiláticas para a prevenção dessa complicação ainda permanece controversa. O objetivo desse estudo clínico, randomizado e controlado foi avaliar o papel da anticoagulação oral na prevenção das lesões venosas pós-implante transvenoso de DCEI em pacientes de

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15

Mezouar, Soraya. "Involvement of platelets in inflammation and cancer." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM5045.

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Dans le cancer, l'activation de la cascade de coagulation et des plaquettes participent à la formation de thromboses, à la croissance tumorale, et les métastases. Ces thromboses représentent une complication clinique chez les patients atteints du cancer du pancréas. Cet état serait dû à expression par la tumeur et leurs microparticules (MPs) de facteur tissulaire (FT). Dans une première partie, nous avons identifié le FT et le FT pathway inhibitor exprimés par les MPs cancéreuses et la P-sélectine plaquettaire impliqués dans la progression tumorale, les métastases et la thrombose associée au c

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16

小林, 真一郎, and Shin-ichiro Kobayashi. "Increased von Willebrand Factor to ADAMTS13 Ratio as a Predictor of Thrombotic Complications Following a Major Hepatectomy." Thesis, 2014. http://hdl.handle.net/2237/20419.

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17

Dandachli, Mourad. "L’efficacité du CD154 monomérique dans le traitement des complications thrombotiques." Thèse, 2016. http://hdl.handle.net/1866/19251.

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CD154 joue un rôle important dans la pathogenèse de plusieurs maladies auto-immunes, ainsi que des dysfonctionnements vasculaires. CD154 est un membre de la famille du facteur de nécrose tumorale (tumor necrosis factor, TNF) d'une importance cruciale dans l'immunité humorale. Cependant, CD154 partage également des fonctions critiques inflammatoires grâce à son interaction avec son récepteur CD40 ou des partenaires de liaison récemment identifiés, à savoir αIIbβ3, α5β1 et αMβ2. Ces réponses impliquent CD154 comme un facteur clé dans les maladies inflammatoires chroniques, notamment les maladies

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18

Washburn, Ashley E. "Hemostatic adaptions following exercise training in patients with cancer." 2012. http://liblink.bsu.edu/uhtbin/catkey/1671230.

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Background: Thrombosis is a common and critical consequence of cancer. Changes in thrombotic potential were examined after exercise training in patients with cancer. Methods: Eight cancer patients (65 ± 11 yrs) completed this study, five exercising and three non-exercising controls. Venous blood samples were obtained at baseline and after approximately 12 weeks of study participation. Weekly physical activity was measured using a standard, validated physical activity questionnaire. APTT, PT, fibrinogen and factor VIII were measured before and after the 12-week intervention. Results: A time x g

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19

Bassa, Fatima Cassim. "Coagulation system abnormalities in human immunodeficiency virus (HIV) positive African (Black) patients with acute upper segment deep vein thrombosis(DVT) of the lower limbs." Thesis, 2006. http://hdl.handle.net/10413/573.

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Background Several case reports and studies have alluded to an increased prevalence of venous thrombosis in human immunodeficiency virus positive (HIV-positive) patients. Although a relationship between HIV infection and thrombotic disease has been suggested, the mechanisms predisposing to thrombosis have not been fully elucidated. Aim A prospective study, to determine possible coagulation factor abnormalities that could explain the predisposition to thrombosis in HIV-infected African (Black) patients, was undertaken. Method African (Black) patients, with acute upper segment deep vein thrombos

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