Relevant bibliographies by topics / Tolerable analgesic

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Tolerable analgesic'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Tolerable analgesic"

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Lukito, Johan Indra. "Kombinasi Analgesik Non-opioid Intravena untuk Tata Laksana Nyeri Akut." Cermin Dunia Kedokteran 50, no. 9 (2023): 509–15. http://dx.doi.org/10.55175/cdk.v50i9.868.

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Konsep analgesia multimodal dianjurkan untuk pengobatan nyeri. Paracetamol dan nonsteroidal antiinflammatory drugs (NSAID) umumnya menjadi analgesik dasar, serta dikombinasikan dengan opioid sesuai kebutuhan. Analgesik intravena (IV) dapat menjadi solusi bagi pasien yang tidak dapat menerima analgesik per oral. Kombinasi paracetamol dan ibuprofen IV menunjukkan efek analgesik yang signifikan, dengan manfaat opioid sparing, antipiretik, serta dengan profil keamanan yang relatif baik pada pasien nyeri akut. The concept of multimodal analgesia is recommended for the treatment of pain. Paracetamol
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C., Muraleemohan, Pratiksha Shetty, Satadru Roy, and B. Rajendra Prasad. "Opioids in the World of Oral and Maxillofacial Surgery- A Review." Journal of Health and Allied Sciences NU 08, no. 03 (2018): 029–33. http://dx.doi.org/10.1055/s-0040-1708760.

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AbstractPain control is one of the most difficult challenges in medicine and a key facet of disease management. The isolation of Morphine by Friedrich Sertürner in 1804 added an essential pharmacological tool in the treatment of pain and spawned the discovery of a new class of drugs known collectively as Opioid analgesics. To date, Morphine and other opioids remain essential analgesics for alleviating pain. However, their use is plagued by major side effects, such as analgesic tolerance (diminished pain-relieving effects), hyperalgesia (increased pain sensitivity), and drug dependence. Despite
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Egbunike, Ifeanyi G., and Betty J. Chaffee. "Antidepressants in the Management of Chronic Pain Syndromes." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 10, no. 4 (1990): 262–70. http://dx.doi.org/10.1002/j.1875-9114.1990.tb02582.x.

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Conditions in which antidepressants have been used include diabetic neuropathy, postherpetic neuralgia, headaches, arthritis, chronic back pain, cancer, thalamic pain, facial pain, and phantom limb pain. Although much of the available information is derived from inadequately controlled trials, it seems that antidepressants provide analgesia in many of these disorders. The analgesic effects tend to be independent of antidepressant effects, and doses of heterocyclic antidepressants used for analgesia seem to be lower than those considered effective in the treatment of depression. Doses should be
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Fürst, Susanna, Zoltán S. Zádori, Ferenc Zádor, et al. "On the Role of Peripheral Sensory and Gut Mu Opioid Receptors: Peripheral Analgesia and Tolerance." Molecules 25, no. 11 (2020): 2473. http://dx.doi.org/10.3390/molecules25112473.

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There is growing evidence on the role of peripheral µ-opioid receptors (MORs) in analgesia and analgesic tolerance. Opioid analgesics are the mainstay in the management of moderate to severe pain, and their efficacy in the alleviation of pain is well recognized. Unfortunately, chronic treatment with opioid analgesics induces central analgesic tolerance, thus limiting their clinical usefulness. Numerous molecular mechanisms, including receptor desensitization, G-protein decoupling, β-arrestin recruitment, and alterations in the expression of peripheral MORs and microbiota have been postulated t
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Raymond, Stephen A., John F. Hutchin, Arnold Degboe, and Kenneth G. Faulkner. "Using oral morphine-equivalent values to track the analgesic effect of treatments in clinical trials." Journal of Clinical Oncology 38, no. 15_suppl (2020): e14075-e14075. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e14075.

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e14075 Background: Patient reported pain is subjective, requiring individuals to grade the feeling of pain as “high” or “low”, typically using a numeric scale. As a supplement to self-reported pain, monitoring the dosage and type of treatment needed to keep pain at a tolerable or comfortable level has been suggested. However, differences in treatments can complicate the ability to compare analgesic effects. One approach to this problem uses a 30 mg oral dose of morphine as a standard to quantify the relative analgesic strength of different pain medications. Methods: For use in clinical researc
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Nazia, Shaikh, Subhedar Rajesh, and Borse Yogesh. "A Comparative Study of Dexamethasone and Magnesium Sulphate as an Adjuvant to 0.5% Bupivacaine in Supraclavicular Brachial Plexus Block." International Journal of Pharmaceutical and Clinical Research 15, no. 4 (2023): 248–57. https://doi.org/10.5281/zenodo.12658854.

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<strong>Introduction:</strong>&nbsp;Upper extremity fractures are usually associated with marked postoperative pain. The goal of postoperative pain management is to reduce pain to a tolerable level with minimal or no associated suffering or distress. Brachial plexus block provides us with an alternative anaesthesia technique for upper limb surgeries that provides excellent surgical conditions and a prolonged duration of postoperative analgesia.&nbsp; The addition of an adjuvant to a local anaesthetic solution has helped in the early onset of blockade with a prolonged duration of anaesthesia an
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Malas, Hosni, Stephanie Hsu, and Yasmin Mohammed. "Office Hysteroscopy: King Hamad University Hospital Experience." Journal of the Bahrain Medical Society 35, no. 1 (2023): 1–8. http://dx.doi.org/10.26715/jbms.35_1_1.

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Background &amp; Objective: Office hysteroscopy (OH) is an efficient alternative for diagnosis and management of intrauterine pathology. The main goal of this study is to determine the usefulness and tolerability of OH in the patient population of a tertiary teaching hospital in the Kingdom of Bahrain. Methods: The total population consists of 101 patients who were prospectively included in the study from 2018 to 2020. The main indication for OH were abnormal uterine bleeding followed by post-menopausal bleeding. Results: The procedure was tolerable without analgesia in 93% of cases, analgesia
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Durairajan, Sheela, Preetha Selva, Rajagopalan Vijayaraghavan, Senthil Kumar Sivanesan, and Srinivasan Vengadassalaapathy. "Investigation on Reliability of Administering an Opioid Analgesic Through an Autoinjector by Exploring the Oxidative Stress Parameters in Albino Wistar rats." Biomedical and Pharmacology Journal 18, no. 2 (2025): 1479–88. https://doi.org/10.13005/bpj/3185.

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Modification in drug release provides efficient drug delivery for the benefit of the consumers in improving their convenience, compliance, safety, and efficacy. The need for self-administration of drugs has also evolved due to extreme conditions like natural and man-made disasters to reduce the malaise and fatality. The purpose of this research is to know the reliability of using an opioid analgesic through a self-injectable device during extremity conditions. The opioid analgesic used in this research was buprenorphine. This self-injectable analgesic autoinjector is a recyclable device with t
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Díaz, Mirelys Valladares, Taimilquis León Perón, and Annelis Pérez Rodríguez. "Morphine - bupivacaine and bupivacaine in gynecological surgeries." MOJ Surgery 10, no. 1 (2022): 26–29. http://dx.doi.org/10.15406/mojs.2022.10.00198.

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Objective: Evaluate the intrathecal use of morphine-bupivacaine and bupivacaine in gynecological surgeries. Material and methods: An analytic longitudinal prospective study was perfomed at the Manuel Piti Fajardo Hospital in Florida, from February 2019 to March 2020. The universe was compound by 180 patients. Sample was select about 60 patients by probabilistic simple randon sampling distributed in two groups: A (Morphine -Bupivacaine) and B (Bupivacaine) according to inclusion criteria. The data were collected in questionnaire properly to investigation with baseline data in Statistical Packag
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Taneja, Akshat, Akash Gupta, Malti Agrawal, Upasana Asooja, and Ashok Taneja. "A PROSPECTIVE RANDOMIZED STUDY TO EVALUATE THE ANALGESIC AND SEDATIVE EFFECTS OF FENTANYL AND MIDAZOLAM TO NALBUPHINE AND MIDAZOLAM IN PATIENTS UNDERGOING AWAKE FIBEROPTIC." International Journal of Advanced Research 9, no. 09 (2021): 530–38. http://dx.doi.org/10.21474/ijar01/13444.

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Background- Awake nasal or oral flexible fiberoptic intubation (AFOI) is technique of choice in known or anticipated difficult airway . The main aim was to have calm and cooperative patient who can follow verbal commands while maintaining adequate oxygenation . In our study, we compared the analgesic and sedative effects of fentanyl and midazolam with nalbuphine and midazolam in patients undergoing awake fiberoptic intubationmore tolerable and comfortable for the patient but also to ensure optimal intubating conditions. Material and Methods– A prospective, randomized comparison study among p
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Dissertations / Theses on the topic "Tolerable analgesic"

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Lee, Franklin. "The Effects of Rhes on Opioid Analgesia." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1254.

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Rhes (Ras homolog enriched in striatum) has been identified as a novel monomeric G-protein involved in dopaminergic and other signaling in the striatum. Given the many effects of opioids that involve striatal circuitry, genetically engineered mice that are incapable of making Rhes (rhes-/-) and their control littermates (rhes+/+) were subjected to behavioral tests to determine if any differences existed in opioid analgesia, tolerance, withdrawal, reward, and locomotion. Rhes-/- mice showed an increased opioid mediated analgesia, along with an absence of tolerance and decrease in withdrawal whe
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Winter, Lara. "Characterisation of the neurosteroid analgesic alphadolone." Monash University, Dept. of Anaesthesia, 2004. http://arrow.monash.edu.au/hdl/1959.1/9669.

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Davis, Kristina. "Associative tolerance to nicotine's analgesic effects studies on number of conditioning trials and corticosterone /." Thesis, Texas A&M University, 2003. http://hdl.handle.net/1969/32.

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Baiamonte, Brandon. "The Interaction of Pain and Morphine on Analgesia, Locomotion, and Cognitive Functioning." ScholarWorks@UNO, 2010. http://scholarworks.uno.edu/td/1207.

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Opioid medications are medicine's best weapon against severe intractable pain, but prolonged use of these medications can be complicated by side effects like tolerance and mental clouding which, themselves, can be disabling. The present study examined the independent and combined effects of inflammatory pain and opioid medication on spatial memory for a well learned task in Sprague-Dawley rats. The Hargreaves method was used to verify the pain state of the animals after complete Freund's adjuvant injection and morphine treatment. Whereas pain had little effect on spatial memory, morphine had p
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Louppe, Benoit. "Effet analgesique et tolerance ventilatoire de la nalbuphine a la periode post-operatoire de la chirurgie thoracique." Nancy 1, 1988. http://www.theses.fr/1988NAN11043.

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Bird, Mark Francis. "Investigating the potential of novel bivalent pharmacophores and tetra-branched opioids to produce analgesics with diminished tolerance and dependence profiles." Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/39639.

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All clinical opioid analgesics target the MOP (Mu Opioid Peptide) receptor. While these drugs provide analgesia, long-term treatment leads to tolerance and dependence. By targeting MOP and another member of the opioid receptor family, such as DOP (Delta Opioid Peptide receptor) or NOP (Nociceptin Orphanin F/Q Opioid Peptide receptor), these adverse effects are attenuated. Furthermore, solely targeting DOP or NOP may produce analgesia without the adverse effects associated with MOP. Three groups of variably mixed ligands have been developed; i) Fentanyl-based DOP and NOP bivalents, ii) peptide
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Bulka, Aleksandra. "Genetic differences in neuropathy and opioid responses in rats /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-753-3/.

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Khallouk, Rachida. "Etudes fonctionnelles des adaptations induites par la stimulation chronique des récepteurs opioïdes de type mu et delta." Rouen, 1993. http://www.theses.fr/1993ROUES015.

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L'administration chronique par voie intracérébroventriculaire de thiorphan, un inhibiteur de l'enképhalinase, induit une tolérance à son effet analgésique, évalué par la latence du saut sur le test de la plaque chaude et à son effet stimulant moteur. Le développement de cette tolérance s'accompagne d'une diminution du taux d'ARN messagers de la préproenképhaline A striatale, précurseur des enképhalines endogènes tandis qu'aucune modification de l'activité enképhalinasique n'a été notée. La tolérance à l'effet analgésique de l'acétorphan n'est pas croisée avec celle de la morphine. De façon sim
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Carcolé, Estrada Mireia 1988. "Role of the sigma-1 receptor in the pathophysiology of osteoarthritis pain." Doctoral thesis, Universitat Pompeu Fabra, 2019. http://hdl.handle.net/10803/668154.

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Osteoarthritis is the most common musculoskeletal disease worldwide, characterized by degradation of the articular cartilage, chronic joint pain and disability. Currently available treatments for osteoarthritis have limited efficacy and significant side effects. Understanding the neurobiological mechanisms involved in the development and maintenance of this chronic pain condition and the pain-related comorbidities is crucial to develop novel therapeutic alternatives. The present thesis is focused on the role of the sigma-1 receptor (σ1R), a chaperone expressed in key areas for pain control, mo
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Drieu, la Rochelle Armand. "Etude des interactions fonctionnelles entre récepteurs à peptide RF-amide et caractérisation de ligands bifonctionnels des récepteurs mu opioïde et NPFF." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ109/document.

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Les opiacés demeurent des molécules incontournables dans le traitement des douleurs moyennes à sévères. Si leur efficacité dans le traitement de la douleur aiguë est incontestable, leur utilisation chronique est responsable de nombreux effets indésirables comprenant une hypersensibilité à la douleur et une tolérance à leurs effets analgésiques. Une partie de ces effets secondaires résulteraient de l’activation de systèmes anti-opioïdes endogènes, comme les neuropeptides RF-amide, dont des études précédentes suggèrent une complémentarité de fonctionnement dans la modulation de la douleur. Le pr
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Books on the topic "Tolerable analgesic"

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Hain, Richard David William. Tolerance to optoid analgesia in children. National Library of Canada, 1993.

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Lussier, David, and Russell K. Portenoy. Adjuvant analgesics. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0097.

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In the management of pain associated with serious illness, ‘adjuvant analgesics’ usually are administered in concert with opioid therapy in an effort to improve outcomes when an opioid does not provide satisfactory relief with tolerable side effects. They may be divided into categories, including multipurpose drugs, and drugs used selectively for neuropathic pain, bone pain, pain due to bowel obstruction, or musculoskeletal pain. These drugs are selected for a trial based on limited data available and clinical experience; sequential trials may be undertaken when pain is refractory. Multipurpos
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Fomberstein, Kenneth, Marissa Rubin, Dipan Patel, John-Paul Sara, and Abhishek Gupta. Perioperative Opioid Analgesics of Use in Pain Management for Spine Surgery. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190626761.003.0004.

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This chapter compares the basic properties of several opioid analgesics and explores their applications in perioperative pain control in spine surgery. Parenteral opioids have long been the cornerstone of treatment for postoperative pain; they work by inhibiting voltage-gated calcium channels and increasing potassium influx, which results in reduced neuronal excitability, thereby inhibiting the ascending transmission of painful stimuli and activating the descending inhibitory pathways. This chapter reviews concepts including opioid conversion and rotation, opioid tolerance, and opioid cross-to
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Galvin, Sinead, Lisa Burry, and Sangeeta Mehta. Rethinking Sedation in the ICU. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199653461.003.0040.

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Analgesic and sedative medications are commonly given to manage pain, anxiety, and delirium in critically ill patients; such agents are also used to facilitate painful procedures and to promote greater tolerance of mechanical ventilation. The manner in which we administer, titrate, and monitor analgesia and sedation in the ICU can have an impact on both short- and long-term patient outcomes. The benefit of sedation strategies that limit drug exposure and promote greater wakefulness and patient interaction has been demonstrated in several randomized trials. The overall objective of sedation in
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Yousefshahi, Fardin, Giuliano Michelagnoli, and Juan Francisco Asenjo. Ketamine Use and Opioid-Tolerant Cancer Patients. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190271787.003.0031.

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Pain occurs in up to 70% of cancer patients and it can be challenging to manage. The standard for analgesic therapy is the World Health Organization ladder; however, up to 25% of patients don’t reach a level of comfort using this approach. Ketamine has been recognized as an excellent adjuvant for cancer pain treatment, especially when other analgesics have failed. Some randomized clinical trials have confirmed ketamine’s efficacy in refractory cancer pain, but most had small sample sizes and low power. Some publications have confirmed the beneficial effect of oral, intranasal, subcutaneous, or
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Zelisko, Michael Blaine. The Opioid-Tolerant Patient. Edited by Erin S. Williams, Olutoyin A. Olutoye, Catherine P. Seipel, and Titilopemi A. O. Aina. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190678333.003.0036.

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Caring for the opioid-tolerant patient presents several challenges in the perioperative period, including a higher incidence of anxiety, pain, and unanticipated hospital admission. The goal of the anesthesiologist is to provide sufficient analgesia while preventing withdrawal symptoms. This chapter reviews multimodal analgesia techniques, and addresses opioid tolerance, opioid-induced hyperalgesia, opioid rotation, and the use of methadone during the perioperative period.
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Souza, Dmitri, Denis Snegovskikh, and Julia K. Hunter. Patients with Substance Abuse and Chronic Pain. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190271787.003.0032.

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Treating chronic pain in patients with a substance abuse history is challenging. Patients abusing opioids may have a high pain tolerance, making pain control difficult. Available treatments for acute pain include regional and multimodal analgesia. Non-opioid and nonpharmacological analgesia (including interventional modalities, physical rehabilitation, chiropractic manipulations, and pain psychology) can be used to treat chronic pain. Patients’ past and present opioid use—illicit drug or nonmedical prescription opioid use, maintenance on medication-assisted treatment, or abstinence—should be t
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Welechew, Edward. Treatment of pain in burns patients. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199234721.003.0009.

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Pain from burns has three components: background, breakthrough, and procedural pain. Central sensitization is an important component of the ongoing pain. Early management of pain, prior to the arrival at hospital is essential. Multimodal treatment including opiates will be necessary and psychological support is key. Procedural pain is of high intensity and short duration, and will require a combination of pharmacological and non-pharmacological methods of analgesia. Central sensitization and opiate tolerance are common problems in burns patients.
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Beaulieu, Pierre. Mechanisms of action of acetaminophen for pain treatment. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0046.

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The landmark paper discussed in the chapter, published by 2008 by Mallet et al., reports on the mechanisms of action of acetaminophen for pain treatment. Acetaminophen, also known as paracetamol (N-acetyl-para-aminophenol), has analgesic and antipyretic properties and has superior tolerance, compared to non-steroidal anti-inflammatory drugs, making it appropriate for widespread use in patients. However, despite many years of use worldwide and numerous studies, acetaminophen’s mechanism of action is still uncertain. The article by Mallet et al. is a landmark paper because it reconciled many obs
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Jones, Alison L. Management of opioid poisoning. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0319.

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Opioids are ‘morphine like’ substances that have actions at specific opioid receptors (especially µ receptors) in the central nervous system (CNS). Tolerance of respiratory depression develops at a slower rate than analgesic tolerance, placing patients with a long history of opioid use at particular risk for respiratory depression. If chronic users abruptly stop taking opioids, they develop an acute withdrawal syndrome. Most opioid toxicity is the result of inadvertent overdosage during recreational use or in self-harm, but it can also be due to medication misuse and drug errors. It is charact
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Book chapters on the topic "Tolerable analgesic"

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Basbaum, A. "Mechanisms of Opioid Analgesia and Tolerance." In Pain Management and Anesthesiology. Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-5145-0_1.

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Lefkof, Jason D., Ryan Hill, and Konstantinos Sarantopoulos. "Opioid Analgesics, Tolerance, Dependence and Addiction." In Anesthesiology In-Training Exam Review. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-87266-3_70.

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Stormorken, Anne. "Tolerance and Withdrawal in Critically Ill Children." In Sedation and Analgesia for the Pediatric Intensivist. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-52555-2_11.

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Burns, Lindsay H., Todd W. Vanderah, and Hoau-Yan Wang. "Ultra-Low-Dose Opioid Antagonists Enhance Opioid Analgesia and Reduce Tolerance." In Opiate Receptors and Antagonists. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-197-0_1.

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Pasternak, Gavril W., and Yuri Kolesnikov. "The NMDA/Nitric Oxide Synthase Cascade in Opioid Analgesia and Tolerance." In Glutamate and Addiction. Humana Press, 2002. https://doi.org/10.1007/978-1-59259-306-4_28.

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Portenoy, Russell K., Ebtesam Ahmed, and Mona Patel. "Adjuvant analgesics." In Oxford Textbook of Palliative Medicine, edited by Nathan I. Cherny, Marie T. Fallon, Stein Kaasa, Russell K. Portenoy, and David C. Currow. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198821328.003.0042.

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In the management of pain associated with serious illness, ‘adjuvant analgesics’ are usually administered in conjunction with opioid therapy in an effort to improve outcomes when an opioid does not provide satisfactory relief with tolerable side effects. They may be divided into categories, including multipurpose drugs, and drugs used selectively for neuropathic pain, bone pain, or pain due to bowel obstruction. These drugs are selected for a trial based on limited data available and clinical experience. Multipurpose drugs may be considered for any type of pain. The most useful include cortico
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Ramírez-Paesano, Carlos, Claudia Rodiera Clarens, José Carlos Torres Mandujano, et al. "Role of Ketamine as Part of the Anti-Hyperalgesic Approach in Opioid-Free Anesthesia (OFA) and Postoperative Analgesia (OFAA)." In Ketamine Revisited - New Insights into NMDA Inhibitors [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.100424.

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There is increasing evidence of the close relationship between persistent activation of the glutaminergic pathway, central sensitization, hyperalgesia and chronic pain. Opioids have long been the standard analgesics used in the perioperative. However, their side effects, namely opioid-induced hyperalgesia, opioid tolerance and post-operative dependence in patients with chronic pain that are to undergo aggressive surgeries have motivated anesthesiologists to develop alternative anesthetic techniques. They include analgesic and anti-inflammatory drugs that act by modulating the nociceptive pathw
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Mercadante, Sebastiano. "Problems with Opioid Dose Escalation in Cancer Pain: Differential Diagnosis and Management Strategies." In Topics in Palliative Care. Oxford University PressNew York, NY, 2001. http://dx.doi.org/10.1093/oso/9780195132205.003.0014.

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Abstract Chronic opioid therapy has been recognized as standard management for cancer pain. Analgesia can be achieved with different opioid dosages in individuals, as there is effectively no ceiling to their analgesic effect and the proportion of adverse effects that the patient can tolerate is usually the limiting factor of the dose used. Thus, analgesic dosage should be titrated to effect. However, opioid escalation may have different causes in the course of the illness, and several factors can interfere with an appropriate analgesic opioid response.
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Mao, Jianren, and Lucy Chen. "Opioid Tolerance." In Pain and Chemical Dependency. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195300550.003.0015.

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Abstract The development of opioid tolerance is an intrinsic pharmacological phenomenon of opioid receptors following exposure to opioid agonists (O’Brience, 1996; Reisine and Pasternak, 1996). Although the time course and degree of opioid tolerance vary in clinical settings, profound tolerance to opioid analgesics sometimes necessitates an opioid dose escalation in order to achieve the clinical analgesic effect of opioids. Opioid dependence is also an intrinsic phenomenon of opioid receptors, which may or may not be associated with the development of opioid tolerance. This chapter will focus
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Sinatra, Raymond S., and Sukanya Mitra. "Treatment of Acute Pain in the Opioid-Dependent Patient in the Perioperative Setting." In Pain and Chemical Dependency. Oxford University PressNew York, NY, 2008. http://dx.doi.org/10.1093/oso/9780195300550.003.0033.

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Abstract Patients exhibiting diminished opioid response, whether those presenting with high-grade tolerance or others demonstrating paradoxical treatment induced hyperalgesia, can pose significant and unique challenges to perioperative care providers. This chapter focuses on the clinical implications of opioid tolerance and opioidinduced hyperalgesia, and offers guidelines for patient assessment and acute pain management in the perioperative setting. For opioid tolerant patients in the perioperative setting, higher than standard doses of opioids will often be required. A balanced analgesic app
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Conference papers on the topic "Tolerable analgesic"

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Sorokina, Nina, and Marina Starostina. "THE EFFECT OF MYELOPEPTIDES ON MORPHINE ANALGESIC TOLERANCE IN C57BL/6J MICE." In XVII INTERNATIONAL INTERDISCIPLINARY CONGRESS NEUROSCIENCE FOR MEDICINE AND PSYCHOLOGY. LCC MAKS Press, 2021. http://dx.doi.org/10.29003/m2331.sudak.ns2021-17/352-353.

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Zernig, G. "Degree of clinically quantified tolerance to the desired effects of and adverse drug reactions to the full mu opiod receptor agonist morphine, methadone and fentanyl and to the partial agonist buprenorphine during opioid maintenance and analgesic treatment." In XVth Symposium of the Task Force Therapeutic Drug Monitoring of the AGNP. Georg Thieme Verlag, 2024. http://dx.doi.org/10.1055/s-0044-1779563.

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Reports on the topic "Tolerable analgesic"

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Lumpkin, Shamsie, Isaac Parrish, Austin Terrell, and Dwayne Accardo. Pain Control: Opioid vs. Nonopioid Analgesia During the Immediate Postoperative Period. University of Tennessee Health Science Center, 2021. http://dx.doi.org/10.21007/con.dnp.2021.0008.

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Abstract:
Background Opioid analgesia has become the mainstay for acute pain management in the postoperative setting. However, the use of opioid medications comes with significant risks and side effects. Due to increasing numbers of prescriptions to those with chronic pain, opioid medications have become more expensive while becoming less effective due to the buildup of patient tolerance. The idea of opioid-free analgesic techniques has rarely been breached in many hospitals. Emerging research has shown that opioid-sparing approaches have resulted in lower reported pain scores across the board, as well
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