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Dissertations / Theses on the topic 'Total synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Watson, Christine Anne Louise. "Total synthesis of bistheonellic acid B/ total synthesis of scytophycin C." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627216.

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2

Mitra, Soumya. "Total synthesis of gomisin O asymmetric total syntheses of eupomatilones 1, 2 and 5; and studies towards total synthesis of mayolide A /." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189449580.

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3

Chan, Bryan Ka Ip. "Total synthesis of streptonigrone." Thesis, University of British Columbia, 2007. http://hdl.handle.net/2429/31581.

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This thesis describes the total synthesis of streptonigrone. The centerpiece of our route to the target molecule is a facile one-pot construction of 3-alkylpyridones developed in our laboratory. The quinoline segment of the target molecule, prepared through a Conrad-Limpach synthesis, was condensed with 2-benzyloxy-3,4-dimethoxybenzaldehyde to afford a chalcone intermediate suitable for our pyridine-forming reaction. The assembly of the central 3-methylpyridone ring of the natural product was then accomplished through the merger of the chalcone with 2-cyanopropanamide. Functionalization of the

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4

Shelton, Ruth E. "Total synthesis of peduncularine." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526451.

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5

Sparling, Brian Andrew. "Total Synthesis of Hyperforin." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11098.

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Hyperforin is the component of the medicinal herb St. John's Wort (Hypericum perforatum) responsible for its antidepressant activity. It works by blocking the reuptake of a variety of neurotransmitters through a unique mechanism of action and may be a critical lead for the treatment of depression and possibly other human diseases. However, the therapeutic potential of hyperforin is severely handicapped by its poor water solubility, facile oxidative degradation, and potent activation of pregnane X receptor, leading to increased expression of many genes involved in xenobiotic metabolism. Acce

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6

Baldwin, Ian Robert. "Total synthesis of acetoxyodontoschismenol." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284653.

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7

Chen, Cheng Yi. "Total synthesis of (+)-stenine /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487684245465948.

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8

Li, Fang. "Total Synthesis of (-)-Acutumine." BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/2193.

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Acutumine is a tetracyclic alkaloid isolated from the Asian vine Menispermum dauricum with selective T-cell cytotoxicity and antiamnestic properties. We have developed a total synthetic route to this congested alkaloid, during which we also found a novel, stereoselective radical-crossover reaction that combines an intramolecular radical conjugate addition with a subsequent enolate hydroxylation. Key features of this synthesis also include a reagent-controlled diastereoselective ketone allylation, an anionic oxy-Cope rearrangement to form a congested quaternary sterocenter, a pyridine-mediated

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9

Phillips, Andrew. "Studies towards the total synthesis of patellazole B." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269364.

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The patellazoles are a family of marine polyketide natural products first isolated from Lissoclinum patella in 1988 by both the Moore and Ireland groups. They exhibit significant cytotoxicity against the HCT 116 human colon tumour cells. To date however, their full 3D stereostructure have yet to be elucidated, which has hindered their development as potential drugs, and hampered full investigation into their biological mechanism of action and has deterred total synthesis efforts. This thesis describes synthetic efforts towards Patellazole B, which exhibits the highest potency of the three main

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10

Rivas, Fatima R. "Synthetic studies towards the total synthesis of norzoanthamine." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2006. http://wwwlib.umi.com/cr/ucsd/fullcit?p3221252.

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Thesis (Ph. D.)--University of California, San Diego, 2006.<br>Title from first page of PDF file (viewed September 8, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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11

Rahn, Volker Siegfried. "Synthetic studies towards the total synthesis of (-)-alstonerine." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401724.

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12

Viseux, Eddy Michel Elie. "Synthetic studies towards a total synthesis of roseophilin." Thesis, University of Sussex, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420509.

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13

Charles, Mark David. "Synthetic studies toward a total synthesis of morphine." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272077.

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14

Chen, Yong. "Synthetic Studies on Total Synthesis of Azaspiracid-3." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385895424.

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15

Shamim, Khalida. "I. Total synthesis of stemonine. II. Studies towards the total synthesis of kendomycin." [Bloomington, Ind.] : Indiana University, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3243781.

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Thesis (Ph. D.)--Indiana University, Dept. of Chemistry, 2006.<br>Title from PDF t.p. (viewed Nov. 18, 2008). Source: Dissertation Abstracts International, Volume: 67-12, Section: B, page: 7099. Adviser: David R. Williams.

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16

Goh, Simin Shermin. "Total synthesis of rubriflordilactone A." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:796adfdf-b4d5-474d-85a6-d2e19c1085db.

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Rubriflordilactones A and B are highly oxygenated nortriterpenoid natural products isolated from Schisandra rubriflora. The latter is of particular biological interest as it shows significant anti-HIV activity. Two transition metal-catalysed cascade cyclisation approaches for the formation of the CDE rings of the rubriflordilactones were developed. Palladium-catalysed cyclisation of bromoenediynes and cobalt-catalysed triyne cyclotrimerisation both transform acyclic precursors into 7,6,5-bisannelated arenes in a single step. Two enantioselective syntheses of the AB ring fragment common to both

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17

Cao, Wei. "Total synthesis of ophiorrhine A, G and ophiorrhiside E and synthetic studies towards the total synthesis of pestalustaine A." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF077.

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L'ophiorrhine A, G et l'ophiorrhiside E sont des alcaloïdes indolomonoterpéniques isolés des plantes Ophiorrhiza japonica et Trichocarpon. Nous avons réalisé la première synthèse totale de l'ophiorrhine A, G et de l'ophiorrhiside E. Plusieurs stratégies ont été explorées pour construire la partie indolopyridone de l'ophiorrhiside E, le précurseur biosynthétique supposé de l'ophiorrhine A. Finalement, le couplage de type Friedel-Crafts de l'indolyl-acétamide avec le chlorure d'acide dérivé de la sécologanine a conduit à l'ophiorrhine G. La cyclodéshydratation d'une forme protégée de ce dernier

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18

Shah, Rushabh Surendra. "Total syntheses of the nakinadine alkaloids." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:c022e538-9ff8-4914-8c17-dc0b3ed1fbae.

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This thesis is concerned with the development of methodology for the asymmetric syntheses of the nakinadine family of marine alkaloids and through these synthetic endeavours, seeks to confirm the structure and assign the relative and absolute configurations of these alkaloids for the first time.

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19

Hassan, Haitham. "Total synthesis of eucophylline : a free-radical approach towards total synthesis of cytotoxic leucophyllidine." Thesis, Bordeaux, 2016. http://www.theses.fr/2016BORD0153/document.

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La thèse décrit la première synthèse totale de l'Eucophylline, le fragment sud de l'alcaloïde Leucophyllidine récemment isolé à partir de Leuconotisgriffithii et L. eugenifolius. La synthèse en 10 étapes comprend une nouvelle méthode d’accès au squelette azabicyclo[3.3.1]nonane par un processus de carbooximation radicalaire d'oléfines à trois composants. Au cours de ces études, nous avons également isolé des énamines présentant des stabilités inhabituelles résultant de leur conformation bicyclique tendue. La synthèse de la partie éburnane, le fragment nord de la Leucophyllidine, a été réalisée

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20

Morris, Joanne Charleen. "The total synthesis of chamuvarinin." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/4114.

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In 2004, the polyketide natural product, chamuvarinin (72) was isolated by Laurens et al. from the roots of Uvaria chamae, a member of the Annonaceae plant family. This unique tetrahydropyran containing acetogenin displayed potent levels of cytotoxic activity against the KB 3-1 cell line with an ED50 value of 0.8 nM. Upon initial isolation the relative and absolute stereochemical assignment of chamuvarinin (72) was unable to be readily achieved through ¹H and ¹³C NMR analysis. The initial synthetic route described herein has enabled the relative and absolute stereochemical determination of cha

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21

Lineswala, Jayana P. "Total synthesis of lavendamycin amides." Virtual Press, 1996. http://liblink.bsu.edu/uhtbin/catkey/1036197.

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The synthesis of 7-N-acetyldemethyllavendamycin butyl amide (47), 7-Nacetyldemethyllavendamycin isopropyl amide (48), 7-N-acetyldemethyllavendamycin amide of piperidine (49), 7-N-acetyldemethyllavendamycin amide of pyrrolidine (50), 7N-acetyldemethyllavendamycin amide of morpholine (51), demethyllavendamycin butyl amide (52), demethyllavendamycin amide of pyrrolidine (53), and demethyllavendamycin amide of morpholine (54) are described. Pictet Spengler condesation of 7-acetamido-2formylquinoline-5,8-dione (28) with tryptophan butyl amide (66), tryptophan isopropyl amide (67), tryptophan amide

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22

Karki, Rajesh. "Total synthesis of oxygenated lavendamycin analogs." Virtual Press, 1998. http://liblink.bsu.edu/uhtbin/catkey/1115420.

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The synthesis of 7-acetyl-11'-benzyloxylavendamycin methyl ester (47), 7acetyl-11'-hydroxylavendamycin methyl ester (48), 11'-hydroxylavendamycin methyl ester (49), 11'-benzyloxylavendamycin methyl ester (50), are described. Pictet-Spengler condensation of 7-N-acetyl-2-formylquinoline-5,8-dione (26) with 5-benzyloxytrytophan methyl ester (45) or 5-hydroxytryptophan methyl ester (46) in dry xylene or anisole directly afforded lavendamycin analogs 47 or 48. Compound 49 was obtained by hydrolysis of 48 with 70% H2SO4 - H2Osolution. Compound 50 was obtained by hydrolysis of 47 with sodium carbonat

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23

Liu, Qingsong. "Large scale total synthesis of apoptolidinone and progress towards the total synthesis of ammocidin." [College Station, Tex. : Texas A&M University, 2006. http://hdl.handle.net/1969.1/ETD-TAMU-1054.

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24

Zhang, Yan Crimmins Michael T. "Total synthesis of (-)-mucocin and studies toward the asymmetric total synthesis of brianthein A." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1414.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Apr. 25, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Chemistry." Discipline: Chemistry; Department/School: Chemistry.

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25

Lefranc, David. "Total synthesis of micrococcin P1." Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/3626.

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This thesis describes the total synthesis of the thiopeptide antibiotic micrococcin P1. It unambiguously elucidates its structure, which has been subject to controversy for over thirty years. The centerpiece of the route to the target molecule is a facile one-pot construction of the central thiazole/pyridine cluster developed in our laboratory. This highlyconvergent route entails a delicate Michael addition to yield a Hantzsch dihydropyridine intermediate, which undergoes further oxidation to the fully aromatised heterocycle. The synthesis was completed by the coupling of this core with a high

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26

Sreekumar, Sanil. "Synthetic studies towards the total synthesis of lancifodilactone G." Thesis, University of Liverpool, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569566.

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This thesis presents our studies towards the first total synthesis of the novel anti- HIV agent lancifodilactone G, which has a highly unusual aliphatic enol. The first chapter provides a survey of architecturally diverse nortriterpenoids that were isolated from the Schisandraceae family. A proposed biosynthetic pathway for lancifodilactone G and closely related natural products provides a rationale for the formation of the consecutive 7/8/5 fused carbo cycles that are unique to Schisandra nortriterpenoids. Chapter 1 goes on to outline the reported strategies to access the core of lancifodilac

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27

Dunn, Stephen Henry. "Total synthesis of norsegoline : synthetic approaches to the cystodytins." Thesis, University of East Anglia, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238806.

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28

Crawford, Claire Frances. "Synthetic studies towards a total synthesis of hemibrevetoxin B." Thesis, University of Leeds, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435783.

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29

Pearson, David James. "Synthetic studies towards the total synthesis of popolohuanone E." Thesis, University of Sheffield, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267117.

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30

Audic, Alexandre. "Synthetic studies towards the total synthesis of hexacyclinic acid." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7790/.

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In the first chapter of this thesis, published works found in the literature about hexacyclinic acid and FR182877 are reported and commented. A quick summary of the previous work done in the Prunet group is also described. In the second and third chapter, a more detailed account of the work undertaken during this PhD was given. Firstly, syntheses of two ABC tricycles incorporating tert-butyl and (trimethylsilyl)ethyl esters were undertaken. These syntheses include two key steps previously developed in the group, a diastereoselective Michael addition and a Snider cyclisation. Multiple condition

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31

Ballette, Roberto. "Total synthesis of (+)-Madangamine D." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/145559.

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Madangamines are a small group of marine alkaloids isolated from sponges of the order Haplosclerida collected by hand using scuba on reefs off Madang, Papua New Guinea. Madangamine A show significant in vitro cytotoxicity against murine leukemia (P388), human lung (A549), brain (U373) and breast (MCF-7). However, no bioactivity data have been reported for madangamines B-E, and further pharmacological research on this alkaloid group has been prevented by the minute amount of alkaloid samples. We present herein the enantioselective synthesis of (+)-madangamine D, which represents the first

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32

Kleinbeck, Florian Karl. "Total synthesis of bafilomycin A₁ /." Zürich : ETH, 2008. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17777.

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33

Bosch, Caroline. "Total Synthesis of Phlegmarine Alkaloids." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399380.

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This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research group. It consists first in the development of an easy procedure to access enantiopure substituted octahydroindoles relevant for natural products synthesis, then in the diversification of a common building block used for the total synthesis of phlegmarine alkaloids allowing access to unprecedented heterocyclic tetrahydrocarbazoles compounds, but most importantly in the achievement of a methodology

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34

Chiba, Hiroaki. "Total Synthesis of Tetrahydroisoquinoline Alkaloids." 京都大学 (Kyoto University), 2013. http://hdl.handle.net/2433/174544.

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35

Xu, Sanjia. "Formal total synthesis of (±)-tetrodotoxin." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/59489.

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This dissertation details a formal total synthesis of (±)-tetrodotoxin, a potent sodium channel blocker, based on a transformation developed in these laboratories: the bimolecular oxidative amidation of phenols. The present route leads to the Du Bois intermediate in 27 steps from a commercial starting material. Because the Du Bois intermediate can be elaborated to tetrodotoxin in 4 steps, this work constitutes a formal synthesis of the natural product in 31 steps. This is competitive with the best known alternatives. A structural revision of the Sato tetrodotoxin intermediate is also provided.

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36

Aulakh, Virender Singh. "Total synthesis of thiocillin I." Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/29493.

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This thesis describes the first total synthesis of Thiocillin I, a thiopeptide antibiotic that is structurally similar to Micrococcin P1. Our group has recently completed the first total synthesis of the latter natural product. In that connection, new methodology had to be devised for the assembly of the central pyridine-thiazole cluster of the molecule. The present work details the development of a considerably more efficient "second generation approach" to that crucial molecular subunit. The new technique relies upon a three-component condensation to form the pyridine core with the full comp

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37

Scutt, James Nicholas. "Total synthesis of (+)-belactosin A." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419852.

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38

Bebbington, David. "Total synthesis of hypoglycin A." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306112.

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39

Hayes, Stewart. "The total synthesis of vigulariol." Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495554.

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(+)-Vigulariol was isolated in 2005 by Sheu and coworkers off the coast of Taiwan and belongs to the cladiellin (eunicellin) class of the 2-11 cyclised cembranoid family of natural products. Vigulariol along with numerous other members of the cladiellin family have been shown to possess interesting biological properties including cytotoxicity against various cell lines. This thesis presents the total syntheses of (±)-vigulariol and (-)-vigulariol, that were completed in 20 steps respectively in an overall yield of 4.1% and 5.9%. The key steps in the synthesis are; a samarium diiodide reductive

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40

Anderson, Regan J. "Total synthesis of variolin B." Thesis, University of Canterbury. Chemistry, 2002. http://hdl.handle.net/10092/6061.

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This thesis describes the development of methodology which has led to the total synthesis of variolin B, a marine alkaloid with potent antitumour properties. In Chapter One, a brief summary of the association of organic synthesis and marine natural products is provided. This is followed by an account of the variolin family of natural products and synthetic efforts that have been directed towards them. A new strategy is proposed that exploits the hidden symmetry in variolin B. Chapter Two covers investigations into the synthesis of the variolin skeleton using a variety of reagent systems. A ra

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41

Brooke, Darby Gerard. "Total synthesis of hydroxystrobilurin A." Thesis, University of Canterbury. Chemistry, 2002. http://hdl.handle.net/10092/6541.

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This thesis describes the first three total syntheses of hydroxystrobilurin A, a member of the strobilurin family of fungicidal natural products which are produced by a variety of fungal species worldwide. Chapter 1 provides an account of the discovery, structure, and biological activity of the strobilurins, describes the total syntheses of strobilurins reported to date, and covers the synthetic and spectroscopic work that has been conducted on the strobilurins by other workers in this department. An overview of the use of palladium-catalysed carbon-carbon bond forming methodologies in synthes

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42

Beiger, Jason James. "Total Synthesis of Aflastatin A." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11040.

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The syntheses of aflastatin A and its C3-C48 degradation fragment are described. The syntheses feature several complex diastereoselective fragment couplings, including a C35-C36 anti-Felkin-selective boron-mediated oxygenated aldol reaction, a C15-C16 Felkin-selective trityl-catalyzed Mukaiyama aldol reaction, and a C26-C27 chelate-controlled aldol reaction involving soft enolization with magnesium. Careful comparison of the spectroscopic data for the synthetic aflastatin A C3–C48 degradation fragment (2) to that reported by the isolation group revealed a structural misassignment in the lactol

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43

George, Ian R. "The total synthesis of lodopyridone." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.663246.

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Natural products are an important and diverse class of compounds; pyrones and pyridones, examples of their chemistry and natural products featuring these structures are discussed. Lodopyridone (75) is introduced as both a highly unusual natural product and a potential NQ02 inhibitor. A number of simple lodopyridone inspired analogues were prepared as potential NQ02 inhibitors and tested for binding to the enzyme. Synthetic studies toward lodopyridone featuring acetylation, rearrangement and cross coupling approaches to the key C-6 C-C bond formation were explored. Pyrone 175 was prepared by Su

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44

Stocksdale, Mark G. "Total synthesis of lavendamycin analogs." Virtual Press, 1992. http://liblink.bsu.edu/uhtbin/catkey/834647.

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The syntheses of 7-N-chloroacetyllavendamycin methyl ester (55), 7-N-butyryllavendamycin methyl ester (56), 7-N-chloroacetyldemethyllavendamycin octyl ester (57), 7-N-butyryldemethyllavendamycin octyl ester (58), 7-N-chloroacetyldemethyllavendamycin isoamyl ester (59), and 7-N-butyryldemethyllavendamycin isoamyl ester (61) are described. Incorporation of the Pictet-Spengler condensation of 7-chloroacetamido-2-formylquinoline-5,8-dione (62) or 7butyramido-2-formylquinoline-5,8-dione (63) with B - methyltryptophan methyl ester (11), L-tryptophan octyl ester (64), or L-tryptophan isoamyl ester (6

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45

Olang, Fatemeh. "Total synthesis of lavendamycin analogs." Virtual Press, 1995. http://liblink.bsu.edu/uhtbin/catkey/958797.

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The synthesis of 7-N -furoyllavendamycin methyl ester (35), 7-N -furoyl demethyllavendamycin methyl ester (36), 7-N -furoyldemethyllavendamycin ethyl ester (37), 7-N -furoyldemethyllavendamycin propyl ester (38), 7-N -furoyl demethyl lavendamycin butyl ester (39), 7-N -furoyldemethyllavendamycin isoamyl ester (40),7-N -furoyldemethyllavendamycin cyclohexyl ester (41), 7-N -furoyldemethyl lavendamycin octyl ester (42), 7-N -furoyldecarboxydemethyllavendamycin (43), and demethyl lavendamycin isoamyl ester (44) are described. Pictet-Spengler condensation of 7-furoylamino-2-formylquinoline-5, 8-di

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46

Stonehouse, Jeffrey Paul. "Total synthesis of (+)-rhizoxin D." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395458.

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47

Martin, Bruce John. "A total synthesis of myxothiazol." Thesis, University of Nottingham, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283643.

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48

Sherlock, Alexandra. "A total synthesis of (+)-lactacystin." Thesis, University of Nottingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431860.

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49

Oehlrich, Daniel. "Total synthesis of luminacin D." Thesis, University of Warwick, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412862.

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50

Tometzki, G. B. "d1-Progesterone : A total synthesis." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374578.

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