Relevant bibliographies by topics / Toxicokinetic model

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Toxicokinetic model'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Toxicokinetic model"

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Dalaijamts, Chimeddulam, Joseph A. Cichocki, Yu-Syuan Luo, Ivan Rusyn, and Weihsueh A. Chiu. "Quantitative Characterization of Population-Wide Tissue- and Metabolite-Specific Variability in Perchloroethylene Toxicokinetics in Male Mice." Toxicological Sciences 182, no. 2 (2021): 168–82. http://dx.doi.org/10.1093/toxsci/kfab057.

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Abstract Quantification of interindividual variability is a continuing challenge in risk assessment, particularly for compounds with complex metabolism and multi-organ toxicity. Toxicokinetic variability for perchloroethylene (perc) was previously characterized across 3 mouse strains and in 1 mouse strain with various degrees of liver steatosis. To further characterize the role of genetic variability in toxicokinetics of perc, we applied Bayesian population physiologically based pharmacokinetic (PBPK) modeling to the data on perc and metabolites in blood/plasma and tissues of male mice from 45
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Poulin, Patrick, and Kannan Krishnan. "A Quantitative Structure-toxicokinetic Relationship Model for Highly Metabolised Chemicals." Alternatives to Laboratory Animals 26, no. 1 (1998): 45–55. http://dx.doi.org/10.1177/026119299802600109.

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The aim of the present study was to develop a quantitative structure-toxicokinetic relationship (QSTkR) model for highly metabolised chemicals (HMCs). The proposed QSTkR model is essentially a physiologically based toxicokinetic (PBTK) model, in which the blood:air and tissue:blood partition coefficients (PCs) are predicted from the molecular structure of chemicals, and the liver blood flow rate (Q1) is used to describe hepatic clearance. Molecular structure-based prediction of the blood:air and tissue:blood PCs was performed from the n-octanol:water and water:air PCs of chemicals obtained wit
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Johanson, Gunnar. "Use of Toxicokinetics in Risk Assessment Based on In Vitro Data." Alternatives to Laboratory Animals 21, no. 2 (1993): 173–80. http://dx.doi.org/10.1177/026119299302100209.

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This presentation addresses some aspects of the methodology, advantages and problems associated with toxicokinetic modelling based on in vitro data. By using toxicokinetic models, particularly physiologically-based ones, it is possible, in principle, to describe whole body toxicokinetics, target doses and toxic effects from in vitro data. Modelling can be divided into three major steps: 1) to relate external exposure (applied dose) of xenobiotic to target dose; 2) to establish the relationship between target dose and effect (in vitro data, e.g. metabolism in microsomes, partitioning in tissue
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Sweeney, Lisa M., Michelle R. Goodwin, Angela D. Hulgan, Chester P. Gut, and Desmond I. Bannon. "Toxicokinetic Model Development for the Insensitive Munitions Component 2,4-Dinitroanisole." International Journal of Toxicology 34, no. 5 (2015): 417–32. http://dx.doi.org/10.1177/1091581815594623.

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The Armed Forces are developing new explosives that are less susceptible to unintentional detonation (insensitive munitions [IMX]). 2,4-Dinitroanisole (DNAN) is a component of IMX. Toxicokinetic data for DNAN are required to support interpretation of toxicology studies and refinement of dose estimates for human risk assessment. Male Sprague-Dawley rats were dosed by gavage (5, 20, or 80 mg DNAN/kg), and blood and tissue samples were analyzed to determine the levels of DNAN and its metabolite 2,4-dinitrophenol (DNP). These data and data from the literature were used to develop preliminary physi
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Sweeney, Lisa M., Elizabeth A. Phillips, Michelle R. Goodwin, and Desmond I. Bannon. "Toxicokinetic Model Development for the Insensitive Munitions Component 3-Nitro-1,2,4-Triazol-5-One." International Journal of Toxicology 34, no. 5 (2015): 408–16. http://dx.doi.org/10.1177/1091581815589000.

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3-Nitro-1,2,4-triazol-5-one (NTO) is a component of insensitive munitions that are potential replacements for conventional explosives. Toxicokinetic data can aid in the interpretation of toxicity studies and interspecies extrapolation, but only limited data on the toxicokinetics and metabolism of NTO are available. To supplement these limited data, further in vivo studies of NTO in rats were conducted and blood concentrations were measured, tissue distribution of NTO was estimated using an in silico method, and physiologically based pharmacokinetic models of the disposition of NTO in rats and
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Sasso, Alan F., Panos G. Georgopoulos, Sastry S. Isukapalli, and Kannan Krishnan. "Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats." Journal of Toxicology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/895391.

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A lipid-based physiologically based toxicokinetic (PBTK) model has been developed for a mixture of six polychlorinated biphenyls (PCBs) in rats. The aim of this study was to apply population Bayesian analysis to a lipid PBTK model, while incorporating an internal exposure-response model linking enzyme induction and metabolic rate. Lipid-based physiologically based toxicokinetic models are a subset of PBTK models that can simulate concentrations of highly lipophilic compounds in tissue lipids, without the need for partition coefficients. A hierarchical treatment of population metabolic paramete
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Filser, J. G., C. Baur, A. Csan Ädy, W. Kessler, and P. E. Kreuzer. "Toxicokinetic Modeling as a Tool for Risk Estimation: 2,3,7,8-Tetrachlorodibenzo-P-Dioxin." International Journal of Toxicology 16, no. 4-5 (1997): 433–48. http://dx.doi.org/10.1080/109158197227053.

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Concepts of toxicokinetic modeling and the relevance of toxicokinetics for understanding dose-response relationships, species scaling, and risk estimation are broached. A physiological one-compartment model for 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) is presented in detail. It describes the TCDD burden of the human body, which results from TCDD-contaminated food, in dependence of age. The model was validated using a series of measured values obtained by other authors and this group. They represent lipid-based concentrations of TCDD in liver, blood, adipose tissue, feces, and mother's milk
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Albert, C., R. Ashauer, H. R. Künsch, and P. Reichert. "Bayesian experimental design for a toxicokinetic–toxicodynamic model." Journal of Statistical Planning and Inference 142, no. 1 (2012): 263–75. http://dx.doi.org/10.1016/j.jspi.2011.07.014.

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Antonissen, Gunther, Siegrid De Baere, Barbara Novak, et al. "Toxicokinetics of Hydrolyzed Fumonisin B1 after Single Oral or Intravenous Bolus to Broiler Chickens Fed a Control or a Fumonisins-Contaminated Diet." Toxins 12, no. 6 (2020): 413. http://dx.doi.org/10.3390/toxins12060413.

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The toxicokinetics (TK) of hydrolyzed fumonisin B1 (HFB1) were evaluated in 16 broiler chickens after being fed either a control or a fumonisins-contaminated diet (10.8 mg fumonisin B1, 3.3 mg B2 and 1.5 mg B3/kg feed) for two weeks, followed by a single oral (PO) or intravenous (IV) dose of 1.25 mg/kg bodyweight (BW) of HFB1. Fumonisin B1 (FB1), its partially hydrolyzed metabolites pHFB1a and pHFB1b, and fully hydrolyzed metabolite HFB1, were determined in chicken plasma using a validated ultra-performance liquid chromatography–tandem mass spectrometry method. None of the broiler chicken show
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Larisch, Wolfgang, Trevor N. Brown, and Kai-Uwe Goss. "A toxicokinetic model for fish including multiphase sorption features." Environmental Toxicology and Chemistry 36, no. 6 (2016): 1538–46. http://dx.doi.org/10.1002/etc.3677.

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Dissertations / Theses on the topic "Toxicokinetic model"

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Pelekis, Michael. "Physiological model based determination of the interspecies toxicokinetic uncertainty factors for organic chemicals." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0009/NQ35620.pdf.

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Namdari, Rostam. "A physiologically based toxicokinetic model of pyrene and its major metabolites in starry flounder, Platichthys stellatus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0021/NQ37737.pdf.

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Smith, Carrie Anne. "THE DEVELOPMENT, EVALUATION AND APPLICATION OF A PHYSIOLGICALLY-BASED TOXICOKINETIC MODEL FOR FLUORANTHENE IN RAINBOW TROUT (Onchorhyncus mykiss)." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1068216356.

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Heine, Simon [Verfasser]. "Development and specification of a toxicokinetic and toxicodynamic growth model of Myriophyllum spicatum for use in risk assessment / Simon Heine." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1065353502/34.

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Hörig, Kerstin Verfasser], Andreas [Akademischer Betreuer] [Schäffer, and Henner [Akademischer Betreuer] Hollert. "Development of a toxicokinetic model for the honey bee (Apis mellifera) colony for the use in risk assessment / Kerstin Hörig ; Andreas Schäffer, Henner Hollert." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1128316633/34.

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Hörig, Kerstin [Verfasser], Andreas [Akademischer Betreuer] Schäffer, and Henner [Akademischer Betreuer] Hollert. "Development of a toxicokinetic model for the honey bee (Apis mellifera) colony for the use in risk assessment / Kerstin Hörig ; Andreas Schäffer, Henner Hollert." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1128316633/34.

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Kim, David Nylander-French Leena A. "Toxicokinetic models of dermal exposure to jet fuel." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,280.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Environmental Sciences and Engineering." Discipline: Environmental Sciences and Engineering; Department/School: Public Health.
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Ratier, Aude. "Modélisation toxico-cinétique de la bioaccumulation de composés organiques persistants par des invertébrés benthiques d’eau douce." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1326.

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La présence de contaminants dans le milieu aquatique soulève la question de leur toxicité pour les organismes. Dans l’évaluation du risque environnemental, les effets d’une contamination sur des organismes sont évalués en deux temps. Tout d’abord, une étude de la toxico-cinétique (TK) du composé d’intérêt a lieu, c’est-à-dire établir le lien entre la concentration d’exposition et la concentration bioaccumulée par l’organisme. Par la suite, une étude toxico-dynamique (TD) est réalisée pour établir le lien entre la concentration du contaminant bioaccumulé dans l’organisme et sa toxicité. La bioa
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Moeun, Brian. "Toxicokinetics and Bioaccumulation of Metals in Wood Frog Tadpoles (Lithobates sylvaticus) Exposed to Sediment Near Oil Sands Mining in Northern Alberta." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38156.

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Bitumen extraction in the Athabasca oil sands in Alberta releases metals to the region. In this study, I performed an uptake-elimination experiment with wood frog tadpoles (Lithobates sylvaticus) to determine the bioaccumulation potential of metals from exposure to MacKay River sediment, an area affected by oil sands contamination, and to uncontaminated reference sediment. Wood frog tadpoles, Gosner stages 28-32, were exposed to two sediments: (1) MacKay River sediment that is enriched in petrogenic hydrocarbons from natural and anthropogenic sources; and (2) an uncontaminated reference
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Evans, Timothy J. "Selected aspects of the toxicokinetics of cadmium and lead in animal and cellular models /." Fulltext PDF download Free to MU Campus, others may purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074398.

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Books on the topic "Toxicokinetic model"

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Krüse, Jacob, Henk J. M. Verhaar, and W. K. de Raat, eds. The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-3437-0.

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Pharmacokinetics and Toxicokinetics. Taylor & Francis Group, 2015.

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(Editor), J. Krüse, H. Verhaar (Editor), and W.K. de Raat (Editor), eds. The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. Springer, 2002.

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Krüse, J., H. Verhaar, and W. K. de Raat. The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals: Proceedings of the Symposium The Practical Applicability of ... in The Hague, The Netherlands, 17-18 Februa. Springer, 2014.

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Book chapters on the topic "Toxicokinetic model"

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Filser, Johannes Georg. "Toxicokinetic Models." In Regulatory Toxicology. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-35374-1_49.

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Filser, Johannes Georg. "Toxicokinetic Models." In Regulatory Toxicology. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-642-36206-4_49-2.

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Filser, Johannes Georg. "Toxicokinetic Models." In Regulatory Toxicology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57499-4_49.

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Verotta, Davide, and Lewis B. Sheiner. "Pharmacokinetic/Pharmacodynamic Models and Methods." In Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4757-1520-0_18.

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Feron, V. J. "The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals." In The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-3437-0_1.

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Corley, Richard A. "Physiologically Based Pharmacokinetic Modeling of the Glycol Ether, 2-butoxethanol, and Its Application in Human Health Risk Assessments and Exposure Guidelines." In The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-3437-0_2.

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Droz, Pierre O. "Application of Pharmacokinetic Modelling to Biological Monitoring." In The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-3437-0_3.

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Reddy, Micaela B., and Annette Bunge. "Dermal Absorption from Pesticide Residues." In The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-3437-0_4.

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Timchalk, Charles, Richard Nolan, Richard Billington, and David L. Eisenbrandt. "Inter-Species Pharmacokinetic Comparison of Organic Acid Herbicides. Is the Dog a Relevant Species for Evaluation of Human Health Risk?" In The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-3437-0_5.

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Nichols, John W. "Modeling the Uptake and Disposition of Hydrophobic Organic Chemicals in Fish Using a Physiologically Based Approach." In The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals. Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-3437-0_6.

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Conference papers on the topic "Toxicokinetic model"

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Dennison, J. "146. Further Development of a Toxicokinetic Simulation Model for Benzene and Other Components of Gasoline in Occupational Risk Assessment." In AIHce 2003. AIHA, 2003. http://dx.doi.org/10.3320/1.2757815.

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Pour, Maryam Karim, Sourodeep Bhattacharjee, Robin Gras, and Ken Drouillard. "The integration of an individual-based model into toxicokinetics to enhance ecological realism in evaluating population-level impacts of exposure to PCB." In 2015 Third World Conference on Complex Systems (WCCS). IEEE, 2015. http://dx.doi.org/10.1109/icocs.2015.7483286.

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Reports on the topic "Toxicokinetic model"

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Banks, H. T., and Laura K. Potter. Well-Posedness Results for a Class of Toxicokinetic Models. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada454441.

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