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Dissertations / Theses on the topic 'Toxicokinetic model'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Pelekis, Michael. "Physiological model based determination of the interspecies toxicokinetic uncertainty factors for organic chemicals." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0009/NQ35620.pdf.

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2

Namdari, Rostam. "A physiologically based toxicokinetic model of pyrene and its major metabolites in starry flounder, Platichthys stellatus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0021/NQ37737.pdf.

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3

Smith, Carrie Anne. "THE DEVELOPMENT, EVALUATION AND APPLICATION OF A PHYSIOLGICALLY-BASED TOXICOKINETIC MODEL FOR FLUORANTHENE IN RAINBOW TROUT (Onchorhyncus mykiss)." Miami University / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=miami1068216356.

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4

Heine, Simon [Verfasser]. "Development and specification of a toxicokinetic and toxicodynamic growth model of Myriophyllum spicatum for use in risk assessment / Simon Heine." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1065353502/34.

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5

Hörig, Kerstin Verfasser], Andreas [Akademischer Betreuer] [Schäffer, and Henner [Akademischer Betreuer] Hollert. "Development of a toxicokinetic model for the honey bee (Apis mellifera) colony for the use in risk assessment / Kerstin Hörig ; Andreas Schäffer, Henner Hollert." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1128316633/34.

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6

Hörig, Kerstin [Verfasser], Andreas [Akademischer Betreuer] Schäffer, and Henner [Akademischer Betreuer] Hollert. "Development of a toxicokinetic model for the honey bee (Apis mellifera) colony for the use in risk assessment / Kerstin Hörig ; Andreas Schäffer, Henner Hollert." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1128316633/34.

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7

Kim, David Nylander-French Leena A. "Toxicokinetic models of dermal exposure to jet fuel." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2006. http://dc.lib.unc.edu/u?/etd,280.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2006.<br>Title from electronic title page (viewed Oct. 10, 2007). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Environmental Sciences and Engineering." Discipline: Environmental Sciences and Engineering; Department/School: Public Health.

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8

Ratier, Aude. "Modélisation toxico-cinétique de la bioaccumulation de composés organiques persistants par des invertébrés benthiques d’eau douce." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1326.

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La présence de contaminants dans le milieu aquatique soulève la question de leur toxicité pour les organismes. Dans l’évaluation du risque environnemental, les effets d’une contamination sur des organismes sont évalués en deux temps. Tout d’abord, une étude de la toxico-cinétique (TK) du composé d’intérêt a lieu, c’est-à-dire établir le lien entre la concentration d’exposition et la concentration bioaccumulée par l’organisme. Par la suite, une étude toxico-dynamique (TD) est réalisée pour établir le lien entre la concentration du contaminant bioaccumulé dans l’organisme et sa toxicité. La bioa

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9

Moeun, Brian. "Toxicokinetics and Bioaccumulation of Metals in Wood Frog Tadpoles (Lithobates sylvaticus) Exposed to Sediment Near Oil Sands Mining in Northern Alberta." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38156.

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Bitumen extraction in the Athabasca oil sands in Alberta releases metals to the region. In this study, I performed an uptake-elimination experiment with wood frog tadpoles (Lithobates sylvaticus) to determine the bioaccumulation potential of metals from exposure to MacKay River sediment, an area affected by oil sands contamination, and to uncontaminated reference sediment. Wood frog tadpoles, Gosner stages 28-32, were exposed to two sediments: (1) MacKay River sediment that is enriched in petrogenic hydrocarbons from natural and anthropogenic sources; and (2) an uncontaminated reference

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10

Evans, Timothy J. "Selected aspects of the toxicokinetics of cadmium and lead in animal and cellular models /." Fulltext PDF download Free to MU Campus, others may purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3074398.

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11

Greenberg, Marc Samuel. "Defining Benthic Organism Exposure: Bioavailability and Effects of Non-Polar Organics." Wright State University / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=wright1074096654.

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12

Brinkmann, Markus [Verfasser], Henner [Akademischer Betreuer] Hollert, and Jörg [Akademischer Betreuer] Oehlmann. "Uptake and effects of dioxin like compounds in fish : in vitro in vivo and cross species extrapolation using physiologically based toxicokinetic models / Markus Brinkmann ; Henner Hollert, Jörg Oehlmann." Aachen : Universitätsbibliothek der RWTH Aachen, 2016. http://d-nb.info/1127143719/34.

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13

Darney, Keyvin. "Towards next generation risk assessment of chemicals : bayesian meta-analysis of human variability in metabolism and transporters and application for the derivation of pathway-related uncertainty factors Aggregate exposure of the adult French population to pyrethroids, in Toxicology and Applied Pharmacology 351, July 2018 Inter-ethnic differences in CYP3A4 metabolism: A Bayesian meta-analysis for the refinement of uncertainty factors in chemical risk assessment, in Computational Toxicology 12, November 2019 Bayesian meta-analysis of inter-phenotypic differences in human serum paraoxonase-1 activity for chemical risk assessment, in Environment International 138, May 2020 Human variability in influx and efflux transporters in relation to uncertainty factors for chemical risk assessment, in Food and Chemical Toxicology 140, June 2020." Thesis, Brest, 2020. http://www.theses.fr/2020BRES0013.

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Dans le monde moderne, les humains sont exposés à une vaste gamme de produits chimiques tout au long de leur vie. L'évaluation des risques des substances chimiques pour l'homme revêt une importance capitale pour la santé publique et permet de calculer des niveaux sûrs d'exposition aiguë et chronique pour des sous-groupes de la population humaine, notamment les nouveau-nés, les enfants, les personnes âgées et les populations d’origine géographique et de polymorphismes génétiques différents. L'application des données cinétiques liées aux voies métaboliques pour tenir compte de la variabilité hum

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14

Shih, Meng-Chiuan, and 施銘權. "Environmental exposure estimation with biomarker measurements using Physisologically-based toxicokinetic model (PBTK model)." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/34586441780793356407.

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博士<br>淡江大學<br>數學學系博士班<br>98<br>Physiologically based toxicokinetic (PBTK) modeling has been well established to study the distributions of chemicals in target tissues. In addition, to address the uncertainties in model parameters and inter-individual variability in PBTK models, the hierarchical Bayesian statistical approach using Markov Chain Monte Carlo (MCMC) simulations has been successfully applied for parameter estimation. Thus, employing PBTK models would be a highly plausible way to estimate the constant inhalation exposure concentration using hierarchical Bayesian approaches. In this d

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15

Xu, Xia. "Toxicokinetic-based survival model for analysis of toxicity data with changing dose /." 2006.

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16

Kulkarni, Tara Aniket Dzurik Andrew Albert. "A physiologically based toxicokinetic (PBTK) model for inhalation exposureto benzene and its engineering applications." Diss., 2004. http://etd.lib.fsu.edu/theses/available/etd-04192004-085052.

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Thesis (Ph. D.)--Florida State University, 2004.<br>Advisor: Dr. Andrew Dzurik, Florida State University, College of Engineering, Dept. of Civil and Environmental Engineering. Title and description from dissertation home page (June 18, 2004). Includes bibliographical references.

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17

Sasso, Alan F. "Development and application of a generalized physiologically-based toxicokinetic model for environmental risk assessment." 2010. http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.000052148.

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18

Gagné, Michelle. "Caractérisation de la pharmacocinétique suite à l’exposition multivoie au toluène, au n-hexane et au cyclohexane chez le rat." Thèse, 2008. http://hdl.handle.net/1866/2817.

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La contribution de l’inhalation et de la voie percutanée à l’exposition totale à des composés organiques volatils (COV) présents dans l’eau potable est une problématique qui suscite un intérêt grandissant en santé publique et au niveau réglementaire. Jusqu’à tout récemment, seule l’ingestion était considérée dans l’évaluation du risque des contaminants de l’eau. L’objectif de ce projet était de caractériser l’impact de l’exposition multivoie sur la pharmacocinétique et la dose interne de trois COV : le toluène (TOL), le n-hexane (HEX) et le cyclohexane (CYCLO). À cette fin, un modèle expérime

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19

Ju, Yun-Ru, and 朱韻如. "Subcellular Partitioning Links Toxicokinetic/toxicodynamic Models to Assess the Susceptibility Risk in Farmed Fish Exposed to Metal Stressors." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/38765924750544317348.

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博士<br>國立臺灣大學<br>生物環境系統工程學研究所<br>100<br>Recently, subcellular metal partitioning has been used for assessing metal toxicity in aquatic organisms. In reality, the environmental metal concentration is tended to be fluctuation and pulse as a result of the site-specific water chemistry conditions. But little researches have been studied by using the subcellular partitioning for aquatic organisms exposed to pulsed metals in the field of ecotoxicology. Hence, the purposes of this dissertation were: (i) to develop an integrated toxicological model by linking subcellular partitioning and toxicokinetic/

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20

Muohi, Ann Wairimu [Verfasser]. "Bioaccumulation of trace metals in biota (algae and chironomids) from Kenyan saline lakes (Bogoria and Nakuru) : evaluation and verification of two compartment toxicokinetic models / von Muohi, Ann Wairimu." 2007. http://d-nb.info/989255743/34.

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