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Dissertations / Theses on the topic 'Toxoid'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Michaelides, Alecos. "Chemical and enzymatic fragmentation of tetanus toxin and immunological studies on anti-tetanus toxin and toxoid sera." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9661.

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This thesis describes the immunization protocols for the production of antibodies against tetanus toxin and toxoid in guinea pigs and mice. Antibodies were successfully raised against the toxin without mortalities in either species. The murine sera obtained, were isotyped by ELISA and the toxin was proven to be a superior antigen in eliciting production of IgG$\rm\sb{2a}$ and IgG$\sb3$. The two isotypes which have demonstrated antitumor activity. The anti-toxoid sera exhibited a lower reactivity towards the toxin and toxoid when compared with anti-toxin sera. The reactivity of recombinant teta
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2

Sheppard, A. J. "Studies on production and characterisation of monoclonal antibodies to tetanus toxin, and their use for developing immunopurified tetanus toxoid and toxin." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235280.

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3

Nijland, Reindert. "Heterologous expression and secretion of Clostridium perfringens [beta]-toxoid by Bacillus subtilis." [S.l. : Groningen : s.n. ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/301153868.

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4

Каплін, Микола Микитович, Николай Никитович Каплин, Mykola Mykytovych Kaplin, Artem Mykhailovych Piddubnyi, Артем Михайлович Поддубный та Артем Михайлович Піддубний. "Динаміка антитоксичного імунітету у донорів, імунізованих стафілококовим анатоксином". Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27043.

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З метою профілактики та лікування важких гнійно-запальних захворювань стафілококової етіології в медичній практиці використовують гіперімунну антистафілококову плазму та специфічний імуноглобулін. Ці препарати отримують шляхом імунізації донорів стафілококовим анатоксином. Ось чому вплив різних факторів на рівень імунної відповіді є одою із важливих проблем сучасної імунології. Дані відносно впливу групи крові на рівень антитоксичного імунітету в літературі мало чисельні та суперечливі. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/27043
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5

Harrington, Noel P. "Suppression of murine splenic mononuclear cell response to mitogen by irradiation and tetanus toxoid: A study of possible mechanisms." Thesis, University of Ottawa (Canada), 1994. http://hdl.handle.net/10393/6528.

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This study examines the possible mechanisms by which radiation and the bacterial toxin, Tetanus toxoid (TT), suppress the murine splenic mononuclear cell (SMNC) response to mitogen. This study demonstrates that the lymphocyte proliferation response of SMNC to the mitogenic lectin PHA can be suppressed by TT in a dose-dependant manner in vitro, without affecting the viability of the cells, in the anti-proliferative concentrations used (0.5-5 $\mu$g/ml). SMNC pre-incubated with TT could suppress the pHA blastogenic response of fresh autologous cells during co-incubation suggestion the involvemen
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6

Stefanovic, Helen. "Suppression of human peripheral blood mononuclear cell response to mitogen by tetanus toxoid. A study of the possible mechanisms." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7603.

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Previous studies have shown that certain antigens can down-regulate immune responses of human peripheral blood mononuclear cells (PBMC) both in vivo and in vitro. This study demonstrates that tetanus toxoid (TT), in a dose-dependent fashion, suppresses the induction of a blastogenic response of PBMC by phytohemagglutinin (PHA), monoclonal anti-CD3, and anti-CD4 antibody. Pokeweed mitogen (PWM)-induction of IgG and IgM is suppressed as well. The suppression is partially reversed by indomethacin and IL-2, but not by IL-1 or tumor necrosis factor (TNF-$\alpha$). PBMC pre-incubated with TT could s
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7

Bartels, Britta Marlen [Verfasser], and Carsten [Akademischer Betreuer] Bokemeyer. "Erfassung von Tetanus-Toxoid- und Influenza-Nukleoprotein-spezifischen Antikörpern bei Patienten mit multiplem Myelom / Britta Marlen Bartels. Betreuer: Carsten Bokemeyer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2012. http://d-nb.info/1021499935/34.

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8

Gatsos, Xenia, and xgatsos@optusnet com au. "The development of live vectored vaccines targeting the alpha-toxin of Clostridium perfringens for the prevention of necrotic enteritis in poultry." RMIT University. Applied Sciences, 2007. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20080212.142403.

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The Ą-toxin of Clostridium perfringens is a toxin involved in numerous diseases of humans and agriculturally important animals. One of these diseases is necrotic enteritis (NE), a sporadic enteric disease which affects avian species world-wide. This study involved the inactivation of alpha-toxin (Ą-toxin) for use as a potential vaccine candidate to combat NE in chickens, and other diseases caused by C. perfringens type A. During the course of this research a number of Ą-toxin recombinant proteins were developed through molecular inactivation of the Ą-toxin gene, plc. Proteins plc3
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9

Rescia, Vanessa Cristina [UNIFESP]. "REVs-Chi: um novo sistema particulado para encapsulação de macromoléculas terapêuticas." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/10065.

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10

Nass, Shafique Sani. "Evaluation of Active and Passive Neonatal Tetanus Surveillance Systems in Katsina State, Nigeria." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2095.

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The incidence and mortality rates of neonatal tetanus (NNT) remain underreported in Nigeria. This cross-sectional study was guided by the Mosley and Chen's model for the elements of child survival in developing countries. The goals of the study were twofold: (a) to compare the NNT prevalence and the mortality rates from the existing surveillance system and active surveillance of health facility records in 7 selected health facilities from 2010 to 2014 in Katsina state, Nigeria and (b) to assess the associations between selected NNT risk factors, number of maternal tetanus toxoid injections, fr
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11

CORBETTA, CRISTINA. "Refining strategies for dendritic cell (DC) –immunotherapy in glioblastoma patients." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241211.

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Nello studio clinico DENDR1, attivo presso la Fondazione IRCCS Istituto Neurologico Carlo Besta, 24 pazienti affetti da glioblastoma primario sono stati sottoposti a sette vaccinazioni con cellule dendritiche (DC) in combinazione al chemioterapico temozolomide (TMZ) come adiuvante. 9 pazienti hanno beneficiato del trattamento e l’aumento della sopravvivenza è correlato ad una persistente risposta mediata da cellule natural killer, ma non da linfociti CD8. Nello specifico, il trattamento con TMZ ha avuto un impatto negativo sull’attivazione di una risposta mediata da linfociti CD8 compromettend
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12

Cunha, Tulio Nakazato da. "Estudo da imunogenicidade de antígenos de Neisseria meningitidis: utilização de toxóide como adjuvante, vetorizado em lipossomas, no modelo camundongo." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-17042009-180710/.

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N.meningitidis é diplococcus gram-negativo, patógeno estritamente humano que similarmente a outras bactérias é circundado por membrana externa, com lipídios, proteínas (OMP) e lipopolissacárides. Ela tem sido uma das principais causas da meningite e de outras infecções invasoras no mundo. Este trabalho buscou usar o toxóide STX2 de E.coli como adjuvante para um possível e futuro modelo vacinal e como estimulante antigênico, proteínas da membrana externa do meningococo (OMP) transportados em lipossomas. Observaram-se diferenças na produção de anticorpos IgG obtidas entre os camundongos após cad
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13

Van, der Westhuizen Elaine. "Chitosan derived formulations and EmzaloidTM technology for mucosal vaccination against diphtheria : oral efficacy in mice / Elaine van der Westhuizen." Thesis, North-West University, 2004. http://hdl.handle.net/10394/633.

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Vaccination plays a very important part in daily life. It is essential to get vaccinated at an early age. The conventional parented method used is not always effective and not cost efficient. It requires qualified personnel and sterile conditions for administration of the vaccines. The aim of this study was to investigate the effect of chitosan, N-trimethyl chitosan chloride (TMC) and Emzaloid™ particles on the local and systemic immune response of mice after oral vaccination with Diphtheria toxoid (DT). The different formulations used were chitosan microparticles (± 10 µm), chitosan nanoparti
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14

Musana, Imelda Atai Madgalene. "Effect of Access to Health Services on Neonatal Mortality in Uganda." ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7828.

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Since 2006, Uganda has experienced a nonchanging neonatal mortality rate of 27 out of 1,000 live births, which is higher than the global average of 19 deaths for every 1,000 live births. The purpose of this retrospective cross-sectional study was to determine factors affecting access to health services and their impact on newborn deaths in Uganda. Mosley and Chen's model for child survival in developing nations provided the framework for the study. Secondary data from the 2016 demographic and health survey (UDHS) collected by the Uganda Bureau of Statistics (UBOs) was used. A total of 7,538 ca
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15

Truter, Erika Mare. "Chitosan derived formulations and EmzaloidTM technology for mucosal vaccination against diphtheria : nasal efficacy in mice / Erika M. Truter." Thesis, North-West University, 2005. http://hdl.handle.net/10394/858.

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Previous studies have demonstrated that chitosan and its derivative, N-trimethyl chitosan chloride (TMC) are effective and safe absorption enhancers to improve mucosal delivery of macromolecular drugs including vaccines. Furthermore, chitosan and TMC can easily form microparticles and nanoparticles, which have the ability to encapsulate large amounts of antigens. Emzaloid™ technology has proven in the past to be an effective delivery system for numerous drugs. Emzaloids can entrap, transport and deliver large amounts of drugs including vaccines. In this study, the ability of chitosan micropart
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16

Rosten, Patricia Melanie. "The role of toxic shock syndrome toxin-1 in the pathogenesis of toxic shock syndrome." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26527.

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Toxic shock syndrome toxin-1 (TSST-1), an exoprotein produced by some strains of Staphylococcus aureus, is implicated in the pathogenesis of menstrual TSS. However, its role in nonmenstrual TSS is less certain. In order to study the pathogenetic role of TSST-1 in TSS, three approaches were taken: a) to develop an ELISA for detection of TSST-1 in biologic fluids in order to verify TSST-1 production in vivo in TSS patients, b) to quantitate TSST-1 specific antibodies in the serum of TSS patients and controls to determine whether such antibodies are protective, and c) to attempt to identify other
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17

Javid-Khojasteh, Vahideh. "Toxic Shock Syndrome Toxin-1 : detection of the toxin, anti-toxin antibodies and producer organisms in a paediatric burns unit." Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365993.

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18

Bortolatto, Juliana. "Toll-like receptor 4 (TLR4) na modulação da imunidade do tipo 2." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-18112008-172851/.

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Lipopolissacarídeos (LPS), pode tanto proteger quanto exacerbar o desenvolvimento da asma. LPS inicia a ativação da resposta imune via ligação da molécula Toll-like receptor 4 (TLR4) que sinaliza por duas vias distintas, as moléculas adaptadoras MyD88 e TRIF. LPS é um adjuvante que induz resposta do tipo Th1, enquanto que o hidróxido de alumínio (Alum) desperta respostas Th2, porém, a mistura de ambos adjuvantes na indução da resposta alérgica pulmonar ainda não foi investigada. No presente estudo, nós determinamos o efeito de dois agonistas de TLR4, um natural (LPS) e outro sintético (ER-8030
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19

Edwards-Jones, Valerie. "Toxic shock syndrome toxin production in relation to burned patients." Thesis, University of Salford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244871.

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20

Al, Turihi Nour. "Caractérisation et quantification de la toxine et de l'anatoxine tétanique dans les vaccins par spectrométrie de masse." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1103.

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Le médicament prophylactique qui a drastiquement réduit l’impact et la sévérité du tétanos sur les populations humaines est le vaccin antitétanique. Son principe actif appelé anatoxine tétanique résulte de l’inactivation au formaldéhyde de la toxine tétanique. Cette détoxification chimique est une étape critique qui détermine la sécurité, l’antigénicité et l’immunogénicité du vaccin. Pour une meilleure compréhension de ce processus chimique, à l’échelle moléculaire, nous avons dans un premier temps caractérisé l’anatoxine tétanique par chromatographie liquide couplée à la spectrométrie de mass
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21

Passalacqua, Edward F. "X-ray crystallographic studies of toxic shock syndrome toxin-1 and related superantigens." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295442.

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22

Reader, S. J. "Evaluation of in vitro assay for metabolism-mediated toxicology." Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384371.

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23

Schutze, Marie-Paule. "Suppression epitopique et vaccins synthetiques : evidences, mecanismes et alternatives." Paris 6, 1987. http://www.theses.fr/1987PA066619.

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24

Namur, Jocimara Ambrosio de Moraes. "Toxoide diftérico: nova roupagem para uma vacina tradicional." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-30012008-104241/.

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O processo de micrencapsulação de proteínas em microesferas (MS) de PLGA [poli (ácido lactico-co-glicolico)] é fácil de fazer e é uma ferramenta útil para melhorar tanto uma formulação quanto para aumentar a atividade imunológica de vacinas de novas gerações. A MS-PLGA têm caráter adjuvante porque é um sistema particulado e, além disto, controla a liberação do antígeno. O escopo desta tese foi o de dar uma nova roupagem para um antígeno vacinal tradicional e muito bem estudado- o toxoide diftérico (Dtxd). Estudaram-se a produção de MS de tamanho desejado; os mecanismos que controlam danos nas
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25

Li, Haowei. "Characterization of regulatory T cells induced by toxic shock syndrome toxin-1 and their potential application in acute graft-versus-host disease." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/30943.

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Repeated administration of a bacterial superantigen, toxic shock syndrome toxin-1 (TSST-1), has been shown to induce CD4+ regulatory T cells in mice. However, it is not clear if the characteristics of TSST-1-induced Tregs differ from those of Tregs induced by other bacterial superantigens, such as staphylococcal enterotoxin A (SEA). The mechanisms of T TSST-1-induced Tregs are also not well characterized. Because in experimental settings Tregs can be used to effectively treat multiple diseases, the potential application of TSST-1-induced Tregs also needs to be determined. In this study
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26

Kuk, Chiu Ying. "Anthrax Lethal Toxin Is a Tumor Hemorragic Toxin." Thesis, Van Andel Research Institute, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10973827.

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<p> Blood supply is crucial for tumor growth and metastasis. However, current anti-angiogenic therapy is not as effective as predicted, thus a better understanding of the tumor angiogenic process and new anti-angiogenic agent are urgently required. Anthrax lethal toxin (LeTx) has an anti-angiogenic effect on tumors. Tumors treated with LeTx are smaller, paler, and have lower mean vessel density compared to control treated tumors. Most interestingly, compared to current anti-angiogenic treatment, LeTx does not cause normalization of tumor vessels. Instead, tumors treated with LeTx have massive
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27

Rivera, Robert. "Surface displayed toxoids : potential for immunological control of Staphylococcus aureus bovine mastitis." Thesis, Royal Veterinary College (University of London), 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.766316.

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28

Guaiume, Elisângela Aparecida. "Effects of continous administration of low-dose of Escherichia coli lipopolysaccharide in chicks and poults fed non toxic doses of aflatoxin B1 and T-2 toxin." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4309.

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Thesis (M.S.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (July 13, 2006) Includes bibliographical references.
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Islam, Ali. "Disposal of Toxic and Non-Toxic Waste through Lasers : Destruction of toxic solids, liquids and gases Models and Experimental Results." Thesis, KTH, Materialvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-126024.

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The report discusses the destruction of toxic and non-toxic solids, liquids and gases through lasers. In order to completely understand the project first chapters describes the basics about laser and plasma separately, from definition to types, components and categories. Differences between laser and microwave system are covered in this chapter as well. Besides lasers there are different technologies that are currently being used to destroy toxic and non-toxic materials. These technologies were studied and comparison tables are made in order to discern between different destruction technologie
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30

Souza, Anselmo de Santana. "Diminuição da resposta imune ao toxoide tetânico em indivíduos infectados pelo HTLV-1." reponame:Repositório Institucional da UFBA, 2013. http://www.repositorio.ufba.br/ri/handle/ri/13020.

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Submitted by Hiolanda Rêgo (hiolandar@gmail.com) on 2013-09-19T16:24:56Z No. of bitstreams: 1 Tese_Med_ Anselmo de Santana Souza.pdf: 4782838 bytes, checksum: af3640ed9c747b1632ed0e17ef967c30 (MD5)<br>Approved for entry into archive by Flávia Ferreira(flaviaccf@yahoo.com.br) on 2013-09-22T23:49:14Z (GMT) No. of bitstreams: 1 Tese_Med_ Anselmo de Santana Souza.pdf: 4782838 bytes, checksum: af3640ed9c747b1632ed0e17ef967c30 (MD5)<br>Made available in DSpace on 2013-09-22T23:49:14Z (GMT). No. of bitstreams: 1 Tese_Med_ Anselmo de Santana Souza.pdf: 4782838 bytes, checksum: af3640ed9c747b1632ed0e17
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Cheung, Kai-him Matthew, and 張啟謙. "Bioremediation of toxic metals." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/194562.

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Traditional remediation techniques in removing toxic metal contaminants using physical and chemical methods are expensive and may cause other forms of damage to the environment, comparing with these techniques bioremediation can serve as an inexpensive, effective and environmental friendly remediation method. This thesis mainly discusses different bioremediation techniques and identifies possible areas in Hong Kong for bioremediation and suggests bioremediation methods for each potential area. Bioremediation of toxic metals is the use of microorganisms, plants, or even larger sized organisms t
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32

Bader, Carly. "The cytopathic activity of cholera toxin requires a threshold quantity of cytosolic toxin." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5762.

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Cholera toxin (CT), secreted from Vibrio cholerae, causes a massive fluid and electrolyte efflux in the small intestine that results in life-threatening diarrhea and dehydration which impacts 3-5 million people per year. CT is secreted into the intestinal lumen but acts within the cytosol of intestinal epithelial cells. CT is an AB5 toxin that has a catalytic A1 subunit and a cell binding B subunit. CT moves from the cell surface to the endoplasmic reticulum (ER) by retrograde transport. Much of the toxin is transported to the lysosomes for degradation, but a secondary pool of toxin is diverte
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Schmitt, Christian. "Etude de clones de lymphocytes t humains specifiques de l'anatoxine tetanique." Paris 7, 1987. http://www.theses.fr/1987PA077003.

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Kardinaal, Willem Edwin Adrianus. "Who's bad? molecular identification reveals seasonal dynamics of toxic and non-toxic freshwater cyanobacteria /." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/51515.

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35

Cheng, Gary. "Mindfulness and the Toxic Triangle| Reducing the Negative Impact of Toxic Leadership in Organizations." Thesis, Pepperdine University, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10841008.

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<p>Toxic leadership costs organizations millions at a time in lost employees, lost customers, lost productivity, and even lost health. The literature shows toxic leadership extends beyond just leaders into an interconnected ?toxic triangle? of destructive leaders, conducive environments, and susceptible followers. This study explored, ?Can a free, online mindfulness-based stress reduction course reduce the negative impact of toxic leadership on the organization?? Ten volunteers self-identified as currently working under a toxic leader. The study used an explanatory sequential mixed methods des
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Gao, Haifei. "Chemical biology approaches to study toxin clustering and lipids reorganization in Shiga toxin endocytosis." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB147.

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La toxine bactérienne de Shiga se lie au glycosphingolipide (GSL) globotriaosylcéramide (Gb3) afin d’entrer par endocytose dans les cellules en utilisant une voie dépendante et indépendante de la clathrine. Dans la voie indépendante de la clathrine, la toxine de Shiga réorganise les lipides de la membrane de façon à imposer une contrainte mécanique sur la bicouche, conduisant ainsi à la formation de pic d’invagination d'endocytose profonds et étroits. Mécaniquement ce phénomène n’est pas encore compris, notamment il reste énigmatique, comment se traduisent les propriétés géométriques de l’agré
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Maiello, Stefania <1985&gt. "Characterization and cytotoxic mechanisms of toxic and non-toxic type 2 ribosome-inactivating proteins." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/7932/1/Maiello_Stefania_tesi.pdf.

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Ribosome inactivating proteins (RIPs) are a family of plant proteins that irreversibly arrest protein synthesis through depurination of rRNA. The anticancer, antiviral and neurotoxic properties allow RIPs to have useful applications in agriculture and in many biomedical fields, including clinical drug development. Galactose–binding lectins contained in caudices of four Adenia species were purified by affinity chromatography on CL Sepharose 6B. All lectins agglutinate human erythrocytes. The lectin from A. kirkii, called kirkiin, had the highest toxicity, inhibiting protein synthesis both by c
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Karlsson, Sture. "Toxin production in Clostridium difficile /." Stockholm : Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-77349-812-2/.

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39

Strack, Julia [Verfasser], and Andreas [Akademischer Betreuer] Bechthold. "Osteoklastendifferenzierung durch Pasteurella multocida-Toxin." Freiburg : Universität, 2014. http://d-nb.info/1123480834/34.

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40

Sharma, Davinder Kumar. "Toxin production by Clostridium botulinum." Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301991.

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The endopeptidase activity assay developed for measurement of purified botulinum neurotoxin type A (BoNT/A) in clinical therapeutic preparations has been adopted to provide a specific measure of BoNT/A activity in culture supernatants of proteolytic C. botulinum type A. Electrophoretic studies and inhibition of BoNT/A activity by anti-A antibody confirmed the specificity of the assay. The minimum detection limit was 0.2 MLD50/ml indicating the assay as more sensitive than the standard mouse bioassay or any other in vitro assay available to date. Whilst the assay did not exhibit any cross react
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Jarosz, Maxwell A. (Maxwell Albert). "Toxic urbanism : hearth, heimatlosigkeit, home." Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/108934.

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Thesis: M. Arch., Massachusetts Institute of Technology, Department of Architecture, 2017.<br>Cataloged from PDF version of thesis. Page 123 blank.<br>Includes bibliographical references (pages 121-122).<br>In an increasingly toxic world where the average person's body contains 29/35 of the toxins listed on the restricted and hazardous substance list, toxicity is unavoidable. This thesis asks how toxins can re-imagined to become active agents in design. Through the negotiation between hard and soft boundaries this work speculates on an architecture of gradients, densities, and velocities to pr
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Lawal, Akeem Olalekan. "Molecular mechanisms of cadmium toxic." Thesis, University of Strathclyde, 2009. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=25780.

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Cadmium is a heavy metal which has been associated with a number of pathological diseases. However, despite the known toxicity of this metal, there is inconclusive evidence about its mechanism(s) of action in the cells. The present study was therefore undertaken with the aim of defining the role of oxidative stress, intracellular Ca²⁺ alteration via phospholipase C- Inositol-1,4,5-triphosphate (PLC-IP3) and mitochondrial-cytochrome c dependent pathways in the etiology of cadmium-induced toxicity in three human cell lines: HepG2 (human hepatoma), 1321N1 (human astrocytoma) and HEK 293 (human em
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Saarinen, T. (Teemu). "Toxic behavior in online games." Master's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201706022379.

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Online gaming is the entertainment of the masses nowadays as it entertains hundreds of millions of players around the world on daily basis. Along with the popularity of online gaming, phenomenon of toxic behavior has also taken root in those games. Toxic behavior is strongly present in current day online games and very few people are spared from it nowadays. The purpose of this study was to take a closer look into the toxic behavior and how it affects those who actively play online games. This study started by conducting literature review to identify the various different aspects that surroun
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Romeo, Gino Anthony. "Dechlorination of toxic chlorinated compounds." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/289024.

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It was discovered in our laboratory that the bimetallic system palladium on iron (palladized-iron, Pd/Fe) rapidly and completely hydrodechlorinates aqueous solutions of ubiquitous chlorinated aliphatic and aromatic environmental contaminants such as TCE (trichloroethylene), chlorophenols and PCBs (polychlorobiphenyls) at room temperature and atmospheric pressure. When TCE comes in contact with the Pd/Fe surface, it forms ethane as the major gaseous product. Chlorophenols are converted to phenol and PCBs are converted to biphenyl. It was also discovered that through a series of redox reactions
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Guttenberg, Gregor [Verfasser], and Manfred [Akademischer Betreuer] Jung. "Clostridiale Glukosylierende Toxine: Untersuchungen zur Autoprozessierung von Clostridium sordellii Letalem Toxin und Clostridium novyi alpha-Toxin sowie funktionelle Charakterisierung von Clostridium perfringens TpeL-Toxin." Freiburg : Universität, 2012. http://d-nb.info/1123467994/34.

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MacMaster, Kayleigh A. "Characterization of Cellular Pathways and Potency of Shiga Toxin on Endothelial Cells." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439304438.

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Zhou, Ting. "Isoniazid hepatotoxicity." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29456.

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Isoniazid (INH), one of the most effective agents in the treatment and prophylaxis of tuberculosis associated with a mild increase in liver transaminases in up to 20% of treated patients and severe hepatotoxicity in up to 2% of treated patients. Since the 1970's, a number of studies have been reported on the mechanism of INH-induced hepatotoxicity. The original studies in rats suggested that the hepatotoxic effect of INH was due to the microsomal metabolism of acetylhydrazine (AcHz, a metabolite of INH) to a reactive intermediate. More recently other workers have been unable to reproduce the
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Fong, Yin-shan. "Harmful Algal Blooms (HABs) in coastal waters and their management /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25436247.

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Herrera, Alfa. "Staphylococcus aureus TSST-1 and Beta-toxin contribute to infective endocarditis via multiple mechanisms." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/5775.

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Staphylococcus aureus is a gram positive bacterium asymptomatically colonizing 30-40% of the human population. S. aureus causes a variety of infections including superficial skin lesions, toxic shock syndrome, and infective endocarditis (IE). There are 100,000 cases of IE each year in the United States. IE is a life threatening infection of native/prosthetic valves and the lining of the heart. It is characterized by the formation of vegetations, “cauliflower-like” structures composed of bacteria and host factors. S. aureus is the most commonly identified pathogen (up to 40%) in patients with I
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Rystedt, Alma. "Botulinum Toxin : Formulation, Concentration and Treatment." Doctoral thesis, Uppsala universitet, Neurologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181667.

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Botulinum toxin (BTX) is used in various fields of medicine, including the treatment of hyperhidrosis and cervical dystonia. Botox®, Dysport®, Xeomin® and NeuroBloc® are commercially available BTX products, which are formulated differently and their dosing units are unique. Dosage and concentration of the prepared solution for injection varies considerably among studies comparing the products. Improved guidelines on concentration and dosing when changing from one product to another are warranted. This would ensure the use of the lowest effective doses for good effect, minimal risk of antibody
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