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Dissertations / Theses on the topic 'Transcription factor genes'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

Riaño-Pachón, Diego Mauricio. "Identification of transcription factor genes in plants." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2008/2700/.

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In order to function properly, organisms have a complex control mechanism, in which a given gene is expressed at a particular time and place. One way to achieve this control is to regulate the initiation of transcription. This step requires the assembly of several components, i.e., a basal/general machinery common to all expressed genes, and a specific/regulatory machinery, which differs among genes and is the responsible for proper gene expression in response to environmental or developmental signals. This specific machinery is composed of transcription factors (TFs), which can be grouped int
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2

Harris, Robert. "The regulation of the embryonic transcription factor Pax-3." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342629.

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3

Kannangara, Rubini Maya. "Identification of transcription factor target genes in Arabidopsis thaliana." Thesis, University of York, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444343.

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4

Wiseman, Elizabeth Fiona. "Novel FOXM1 transcription factor target genes in oesophageal cancer." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/novel-foxm1-transcription-factor-target-genes-in-oesophageal-cancer(24278706-fa41-41b9-bf59-1902b1c4ba3d).html.

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The prognosis of oesophageal cancer remains poor, with <10% 5-year survival. Delineating the molecular pathogenesis of oesophageal cancer could inform future research into targeted therapies and may uncover novel biomarkers to aid management decisions. As a transcription factor with important roles in the control of cell cycle transcription, FOXM1 regulates cellular proliferation and chromosome stability. FOXM1 is frequently overexpressed in human cancers and this has recently been described in oesophageal adenocarcinoma (OAC) tissues. We have sought to identify novel gene targets of FOXM1 to
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5

Wang, Tianyuan. "Identifying Transcription Factor Targets and Studying Human Complex Disease Genes." NCSU, 2009. http://www.lib.ncsu.edu/theses/available/etd-03132009-120540/.

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Transcription factors (TFs) have been characterized as mediators of human complex disease processes. The target genes of TFs also may be associated with disease. Identification of potential TF targets could further our understanding of gene-gene interactions underlying complex disease. We focused on two TFs, USF1 and ZNF217, because of their biological importance, especially their known genetic association with coronary artery disease (CAD), and the availability of chromatin immunoprecipitation microarray (ChIP-chip) results. First, we used USF1 ChIP-chip data as a training dataset to develop
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6

Nickel, Gabrielle Celeste. "Positive Selection in Transcription Factor Genes Along the Human Lineage." Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1220370670.

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7

Ellison, Jason. "Identification of target genes of PEA3, an ETS family transcription factor /." *McMaster only, 2001.

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8

Wang, Dongfang, Changqing Zhang, David Hearn, et al. "Identification of transcription-factor genes expressed in the Arabidopsis female gametophyte." BioMed Central, 2010. http://hdl.handle.net/10150/610082.

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BACKGROUND:In flowering plants, the female gametophyte is typically a seven-celled structure with four cell types: the egg cell, the central cell, the synergid cells, and the antipodal cells. These cells perform essential functions required for double fertilization and early seed development. Differentiation of these distinct cell types likely involves coordinated changes in gene expression regulated by transcription factors. Therefore, understanding female gametophyte cell differentiation and function will require dissection of the gene regulatory networks operating in each of the cell types.
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9

Parmar, Vipulkumar Mohanlal. "Transcriptional regulation of metabolic genes by the basic leucine zipper transcription factor Hac1ip and nutrient stimuli." Thesis, Durham University, 2012. http://etheses.dur.ac.uk/3415/.

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Saccharomyces cerevisiae cells respond to nutrients in their environment by altering their metabolic and transcriptional state in order to optimise the use of available nutrients and decide which of the several developmental pathways to pursue. In the yeast S. cerevisiae, meiosis and pseudohyphal growth are two major differentiation outcomes in response to nitrogen starvation. A central component of unfolded protein response pathway, the bZIP transcription factor Hac1ip, negatively regulates meiosis and pseudohyphal growth. The present study investigates this negative regulatory mechanism at e
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10

Fung, Khe Cheong Frederic, and 馮啟昌. "Upregulation of PITX2 transcription factor is associated with ovarian tumorigenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B45988183.

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11

Webber, Aaron. "Transcriptional co-regulation of microRNAs and protein-coding genes." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/transcriptional-coregulation-of-micrornas-and-proteincoding-genes(f5b601b2-33f3-4608-9ae8-b7d5a0c6beaf).html.

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This thesis was presented by Aaron Webber on the 4th December 2013 for the degree of Doctor of Philosophy from the University of Manchester. The title of this thesis is ‘Transcriptional co-regulation of microRNAs and protein-coding genes’. The thesis relates to gene expression regulation within humans and closely related primate species. We have investigated the binding site distributions from publically available ChIP-seq data of 117 transcription regulatory factors (TRFs) within the human genome. These were mapped to cis-regulatory regions of two major classes of genes,  20,000 genes encodi
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12

Lestari, Retno. "Functional analysis in Hevea brasiliensis of the HbERF-IXc4 and HbERF-IXc5 genes, two potential orthologs Arabidopsis ERF1 gene." Thesis, Montpellier, SupAgro, 2016. http://www.theses.fr/2016NSAM0042/document.

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Le caoutchouc naturel (CN), a cis-1,4-polyisoprene, est produit principalement par Hevea brasiliensis. Le CN est un matériau très important pour l’industrie du transport et médicale. La demande en CN augmente d’année en année. Le CN est obtenu à partir du latex. Le latex s’écoule des laticifères après saignée de l’écorce des hévéas. L’éthéphon, un libérateur d’éthylène, peut être appliqué sur certains clones d’hévéa pour stimuler la production de latex. La saignée et la stimulation à l’éthéphon sont des stress de récolte conduisant à la production de métabolites secondaires et par conséquence
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13

Borisevich, Igor. "Analysis of target genes of the transcription factor CREM during mouse spermatogenesis." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=96206257X.

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14

McDade, Donna Marie. "Identification of novel target genes for the plasticity-related transcription factor Zif268." Thesis, University of Glasgow, 2007. http://theses.gla.ac.uk/28/.

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Activity based alterations in synaptic connectivity are thought to underlie the processes involved in learning and memory. Measurable changes in neuronal activation by long-term potentiation (LTP) are widely investigated as a possible cellular correlate of this phenomenon, as it can be induced quickly to elicit long-lasting modifications. These long-term changes in the activity of neuronal circuits are sustained by an altered pattern of gene expression and protein synthesis. The inducible transcription factor Zif268 has been implicated in almost all models of neuronal plasticity. Downstream ta
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15

Glover-Cutter, Kira Marina. "Integration of POL II transcription with pre-MRNA processing on human genes /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado Denver, 2008.<br>Typescript. Includes bibliographical references (leaves 185-214). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
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16

Bolotin, Eugene Leonidovich. "Investigation of transcription factor binding sequences and target genes using protein binding microarrays." Diss., [Riverside, Calif.] : University of California, Riverside, 2010. http://proquest.umi.com/pqdweb?index=0&did=2019822801&SrchMode=2&sid=3&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1274203752&clientId=48051.

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Thesis (Ph. D.)--University of California, Riverside, 2010.<br>Includes abstract. Available via ProQuest Digital Dissertations. Title from first page of PDF file (viewed May 18, 2010). Includes bibliographical references. Also issued in print.
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17

Zhou, Adele. "Imprinting Pattern of Type I Mads-box Transcription-Factor Genes in Arabidopsis Endosperm." Thesis, The University of Arizona, 2011. http://hdl.handle.net/10150/145126.

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18

Jim, Hau Ling. "Identification of target genes of an erythroid transcription factor complex containing SCL (TAL1)." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611270.

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19

Ogo, Ogo Agbor. "Cellular responses to zinc involving the transcription factor ZNF658 and its target genes." Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2752.

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Zinc is an essential trace element that plays a crucial role in catalytic, structural and regulatory functions of many proteins including enzymes and transcription factors; thus maintenance of zinc balance is critical for normal cellular function. Cellular mechanisms that maintain zinc balance include the regulation of genes coding for proteins that play vital roles in zinc homeostasis. These proteins include zinc transporters belonging to the ZIP (SLC39A) and ZnT (SLC30A) families as well as the zinc-binding metallothionein proteins. In contrast to bacterial and yeast systems, a transcription
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20

Persad, Ramona. "Clade A1 heat shock transcription factor genes for environmental stress tolerance in plants." Thesis, University of Essex, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701426.

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Heat shock transcription factors (HSFs) play an important role in providing plants with tolerance or resistance to various environmental stresses. It was proposed that the Clade A1 HSF group may encode the "master regulator(s)" of both the abiotic and biotic stress response, and they were also implicated in growth and development. The number of HSF genes within the Cia de A1 group is highly variable between species, with Arabidopsis having four members compared to Oryza having one equivalent homo log. Previous studies suggested that the Arabidopsis Clade A1 group may have redundant roles in bo
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21

Yagi, Kasumi. "Studies on function of Zic family transcription factor genes in early ascidian embryos." 京都大学 (Kyoto University), 2004. http://hdl.handle.net/2433/147859.

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22

Dellett, Margaret. "Study of Nhlh2 transcription factor and its putative target genes in the retina." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492151.

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Chapter 1 provides an overview ofthe basIc helix-loop-helix (bHLH) and homeodomain families oftranscription factors (TFs) and their role in the developing retina, with examples of abnormal phenotypes associated with their targeted deletion or misexpression. The hypothesis ofNhlh2 involvement in retinogenesis is formulated and it will be tested in the following chapters. Chapter 2 describes the experimental methods employed. Chapter 3 reports Nhlh2 expression pattern by in situ hybridisation (ISH) and PCR in the developing and adult murine retina in the inner nuclear layer (INL) and ganglion ce
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23

Lau, Ko-chun Danny. "Evaluation of thyroid transcription factor-1 (TTF1) and homeobox B5 (HOXB5) as Hirschsprung disease (HSCR) susceptibility loci." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36842291.

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24

Ooi, Lezanne. "An analysis of repressor element 1- silencing transcription factor interactions with its target genes." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426832.

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25

Burden, Morwenna J. "The regulation of E2F." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341993.

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26

Weinschutz, Mendes Hellen. "Dlx Genes, Neurogenesis and Regeneration in the Adult Zebrafish Brain." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/40047.

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The Dlx homeobox genes encode homeodomain transcription factors that are involved in multiple developmental aspects. In the brain, these genes take part in neuronal migration and differentiation, more precisely in the migration and differentiation of GABAergic neurons. Dysfunctions in the GABAergic system can lead to various pathological conditions, where impaired inhibitory function is one of the main causes of several neuropathies characterized by neuronal hyperexcitability. The Dlx genes are organized as bi-gene clusters and highly conserved cis-regulatory elements have been previousl
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27

Essack, Magbubah. "Transcription Regulation and Candidate Diagnostic Markers of Esophageal Cancer." Thesis, University of the Western Cape, 2009. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_5306_1267148426.

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<p>This thesis reports on the development of a novel comprehensive database (Dragon Database of Genes Implicated in Esophageal Cancer, DDEC) as an integrated knowledge database aimed at representing a gateway to esophageal cancer related data. More importantly, it illustrates how the biocurated genes in the database may represent a reliable starting point for divulging transcriptional regulation, diagnostic markers and the biology related to esophageal cancer.</p>
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28

Betts, Melania Figueroa. "Identification of New Pathogenicity Genes in Magnaporthe Oryzae through the Construction of an Agrobacterium Tumefacines-Mediated Insertion Mutant Library." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194453.

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An understanding of plant pathogen-host interactions is essential to design efficient strategies to control disease in crops. Magnaporthe oryzae, an ascomyceteous fungus and causal agent of rice blast disease, is a model organism to study host-microbe interactions. The overall aim of this dissertation project was to identify genes involved in pathogenicity through the construction and characterization of a random insertional mutagenesis library. In order to saturate the genome with DNA inserts, a collection of >54,000 insertion lines of the M. oryzae strain 70-15 was generated via two transfor
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29

Park, Jung. "The transcription factor activator protein family of genes in mammary gland development and breast cancer progression." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/5596.

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Breast cancer is currently the second most common form of cancer and the second leading cause of death due to cancer in the United States. Breast cancer itself is subdivided into at least four subtypes, luminal A, luminal B, HER2-enriched, and basal-like, based on genomewide molecular expression patterns. Luminal A is the most common form and typically characterized by high levels of estrogen receptor (ER). HER2-enriched cancers usually, but not always, harbor amplified copies of the HER2 oncogene. Luminal B cancers share characteristics with the luminal A and HER2-enriched subtypes. Finally,
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30

Kalsi, Megha. "THE XENOBIOTIC TRANSCRIPTION FACTOR CAP N COLLAR C REGULATES EXPRESSION OF MULTIPLE INSECTICIDE RESISTANT GENES." UKnowledge, 2017. https://uknowledge.uky.edu/entomology_etds/34.

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Insecticide resistance is a global problem. Insecticide resistance management is very important, considering the time, effort, and cost of discovering and developing a new insecticide. There are diverse resistance mechanisms, but enhanced detoxification through overexpression of cytochrome P450s and target site insensitivity through mutation in insecticide binding site are the two most common mechanisms. The xenobiotic detoxification is divided into three successive phases (I, II and III), which ensures the metabolism and excretion of the detrimental toxins. Each phase comprises of a specific
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31

Ramdayal, Kavisha. "Incidence and Regulatory Implications of Single Nucleotide Polymorphisms among Established Ovarian Cancer Genes." Thesis, Online access, 2009. http://etd.uwc.ac.za/usrfiles/modules/etd/docs/etd_gen8Srv25Nme4_5111_1277754725.pdf.

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32

Yu, Deli. "Temporal control of muscle gene expression in an ascidian embryo." Kyoto University, 2019. http://hdl.handle.net/2433/242897.

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33

Chanarat, Sittinan. "The Prp19 complex is a novel transcription elongation factor required for TREX occupancy at transcribed genes." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-132497.

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34

Bulcha, Jote Tafese [Verfasser]. "Identification and characterization of ERFIb transcription factor binding motifs and their target genes / Jote Tafese Bulcha." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1038694965/34.

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35

Hartmann, Rico Martin [Verfasser]. "Functional analysis of arbuscular mycorrhiza-related GRAS transcription factor genes of Medicago truncatula / Rico Martin Hartmann." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2018. http://d-nb.info/1165315688/34.

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36

Drane, Emma Louise Antoinette. "Mechanisms of human papillomavirus and host gene transcriptional deregulation in cervical carcinogenesis." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/270255.

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Cervical malignancy is the fourth most common cause of cancer-related mortality in women worldwide; infection with high-risk human papillomavirus (HRHPV) is responsible for over 500,000 cases of cervical carcinoma each year, approximately 90% of which are squamous cell carcinomas (SCCs). Over half of all HPV-positive cervical SCCs are caused by the deregulated expression of HPV16 oncogenes E6 and E7 in proliferating basal cells of the cervical squamous epithelium. The major risk factor associated with cervical neoplastic progression is integration of HRHPV into the host genome, which is detect
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37

Lau, Ko-chun Danny, and 劉高駿. "Evaluation of thyroid transcription factor-1 (TTF1) and homeobox B5 (HOXB5) as Hirschsprung disease (HSCR) susceptibility loci." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B38679851.

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38

Yan, Zejun Jun. "Identification of transcription factors controlling the expression of paclitaxel biosynthesis genes in cambial meristematic cells of Taxus cuspidata." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/11716.

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Paclitaxel is an antitumor diterpene from Taxus spp. that binds tubulin, stabilizes microtubules and induces apoptosis in dividing human cells. It was originally isolated from the bark of Taxus brevifolia and approved for clinic uses by the FDA in 1992. Because of its excellent activity in treatment of various cancers, a significant supply shortage has been created by the enormous demand for this natural product. Thus, researchers have been focusing on the development of effective ways to increase the production of paclitaxel and related bioactive molecules. This shortage was initially solved
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39

Kőszegi, Dávid. "RKD genes : a novel transcription factor family involved in the female gametophyte development of Arabidopsis and wheat." kostenfrei, 2008. http://nbn-resolving.de/urn:nbn:de:gbv:3:4-823.

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40

Shahror, Rami Ahmad Nawaf. "Characterization of the Transcription Factor NF‐Y in the Regulation of Zona Pellucida Genes in Zebrafish Ovary." Thesis, Örebro universitet, Institutionen för naturvetenskap och teknik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-30318.

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Zona pellucida glycoproteins (ZP) are important proteins for maturation of the oocytes in eukaryotes, these proteins are encoded by cluster of zp genes. zp2.3 and zp3.5 genes are expressed during the developing and maturation of the oocytes in zebrafish ovaries. Both of the gens have a CCAAT box in their promoter regions, playing a big role in the expression of the both genes in zebrafish oocytes. The transcription of the genes in the eukaryotes requires transcription factors to initiate and promote the transcription, the transcription factors can bind to the promoter region and initiate the t
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41

Vaughan, Tanya, and n/a. "Identifying Genes Influencing Bone Mineral Density." Griffith University. School of Health Science, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040430.161453.

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Bone mineral density (BMD) is a reflection of the action of osteoblasts compared to osteoclasts. An imbalance in the activity of osteoblasts or osteoclasts, results in bone disease such as osteoporosis caused by overactive osteoclasts. BMD is influenced by genetic and environmental factors as demonstrated through twin studies, association studies and linkage analysis (Ralston, 1999). Several polymorphisms involved in the determination of BMD have been identified, with Vitamin D receptor and Collagen Type 1 showing reproducible associations. To identify genes influencing BMD two distinct st
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42

Andrade, Simone Caixeta de 1977. "Investigação do papel da homeoproteína BARX1 na morfogênese do dente molar em camundongos." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290038.

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Orientadores: Sergio Roberto Peres Line, Marcelo Rocha Marques<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-20T05:35:08Z (GMT). No. of bitstreams: 1 Andrade_SimoneCaixetade_D.pdf: 127365203 bytes, checksum: 4736aaa809aadf03b1ad27e52dbb8b30 (MD5) Previous issue date: 2012<br>Resumo: A dentição não é somente o maior componente do complexo crânio facial dos mamíferos, mas um modelo útil de desenvolvimento, combinado em um sistema de um único órgão, onde ocorrem fenômenos de organização espacial, simetria,
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Shamsuddin, S. "Biochemical characterization of the interactions between a transcription factor, CTCF and its partners Y-Box binding protein-1, and the large subunit of RNA polymerase II." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269484.

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44

Castro, Arce Johanna de. "RAR beta trans-repression of AP-1 transcription factor in HeLa cervical cancer cells consequences on transcription of viral and cellular AP-1 controlled genes /." [S.l. : s.n.], 2003. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB10806332.

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Rapisarda, Valentina. "Mechanisms of epigenetic regulation in epidermal keratinocytes during skin development : role of p63 transcription factor in the establishment of lineage-specific gene expression programs in keratinocytes via regulation of nuclear envelope-associated genes and polycomb chromatin remodelling factors." Thesis, University of Bradford, 2014. http://hdl.handle.net/10454/7164.

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During tissues development multipotent progenitor cells establish tissue-specific gene expression programmes, leading to differentiation into specialized cell types. It has been previously shown that the transcription factor p63, a master regulator of skin development, controls the expression of adhesion molecules and essential cytoskeleton components. It has also been shown that p63 plays an important role in establishing distinct three-dimensional conformations in the Epidermal Differentiation Complex (EDC) locus (Fessing et al., 2011). Here we show that in p63-null mice about 32% of keratin
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46

Hesse, Katrin [Verfasser]. "Insights into function of transcription factor Ap-2δ: target genes and interaction partners / Katrin Hesse. Mathematisch-Naturwissenschaftliche Fakultät". Bonn : Universitäts- und Landesbibliothek Bonn, 2012. http://d-nb.info/1021444812/34.

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47

Gretton, Svetlana. "Investigation of the functional role of the transcription factor, CTCF, in the regulation of human Bax and p14ARF genes." Thesis, University of Essex, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.589445.

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CTCF (CCCTC-binding factor) is a ubiquitously expressed, multifunctional and conserved ll-Zinc finger transcription factor. CTCF is involved in the regulation of various genes, including those responsible for proliferation and apoptosis, using different mechanisms. One such mechanisms is based on reversible poly(ADP-ribosyl)ation (PARylation) of CTCF at the CTCF target sites (CTSs) and requires cooperation between CTCF and the PARylation enzyme, PARP-l. The main aim of this study was to investigate the role ofCTCF, PARP-l and PARylation in the epigenetic regulation of a pro-apoptotic gene, Bax
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48

Bolt, Sylvia [Verfasser]. "Functional and molecular characterization of the phylogenetically related ERF102 to ERF105 transcription factor genes in Arabidopsis thaliana / Sylvia Bolt." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1149050543/34.

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49

Das, Orpita. "Role of the KNAT7 transcription factor in diurnal regulation of lignin biosynthetic genes and resource allocation in Arabidopsis thaliana." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54027.

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Lignified secondary cell walls in plants represent an irreversibly deposited final metabolic sink for global fixed carbon reserves and synthesis of these walls is an energetically expensive process for the plant; hence it follows that spatial-temporal control of secondary cell wall biosynthesis must be closely co-ordinated with carbon metabolism. The function of the KNOTTED ARABIDOPSIS THALIANA 7 (KNAT7) homeodomain protein, a repressor of transcription and part of the multi-level network of transcription factors regulating secondary cell wall biosynthesis and deposition, was studied to invest
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50

Lombe, Chipampe Patricia. "Analysis, expression profiling and characterization of hsa-miR-5698 target genes as putative dynamic network biomarkers for prostate cancer: a combined in silico and molecular approach." University of the Western Cape, 2019. http://hdl.handle.net/11394/7026.

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Philosophiae Doctor - PhD<br>2018, the International Agency for Research on Cancer (IARC) estimated that prostate cancer (PCa) was the second leading cause of death in males worldwide. The number of deaths are expected to raise by 50 % in the next decade. This rise is attributed to the shortcomings of the current diagnostic, prognostic, and therapeutic biomarkers used in the management of the disease. Therefore, research into more sensitive, specific and effective biomarkers is a requirement. The use of biomarkers in PCa diagnosis and management takes advantage of the genetic alterations and a
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