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Dissertations / Theses on the topic 'Transcription factors'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Yao, Ya-Li. "Regulation of yy1, a multifunctional transciption [sic] factor /." [Tampa, Fla.] : University of South Florida, 2001. http://purl.fcla.edu/fcla/etd/SFE0000626.

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2

Zandvakili, Arya. "The Role of Affinity and Arrangement of Transcription Factor Binding Sites in Determining Hox-regulated Gene Expression Patterns." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535708748728472.

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3

Elzi, David John. "Transcriptional properties of the Kaiso class of transcription factors /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5027.

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4

Bidon, Baptiste. "Mediator and NER factors in transcription initiation." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ093/document.

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La synthèse d’ARN messagers résulte d’une cascade d’évènements temporellement et spatialement orchestrée. Au moment de l’initiation de la transcription, divers facteurs tels que les facteurs généraux de transcription, le complexe Médiateur, des co-activateurs, des facteurs de remodelage de la chromatine ainsi que l’ARN polymérase II sont recrutés au niveau de la région promotrice du gène. Certains facteurs de la voie NER de réparation de l’ADN sont également recrutés. En utilisant des cellules de patients porteurs de mutations dans les gènes MED12 (sous-unité du Médiateur) ou XPC (facteur init

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5

Brunkhorst, Adrian. "A study on the TFIID subunit TAF4 /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-206-3/.

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6

Dennis, Jonathan Hancock. "Transcriptional regulation by Brn 3 POU domain containing transcription factors." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249684.

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7

Greberg, Maria Hellqvist. "Cloning and characterization of FREACs, human forkhead transcription factors." Göteborg : Dept. of Cell and Molecular Biology, Göteborg University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39751934.html.

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8

Chanapai, Seni. "Photocontrol of artificial transcription factors." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/58014/.

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The design of a photoswitchable homeodomain artificial transcription factor (PATF), modelled on an engrailed homeodomain, for the purpose of controlling DNA binding affinity and controlling the transcription process in cells using light has been investigated. This study was conducted using a 3,3’-bis(sulfo)- 4,4’bis(chloroacetamino)azobenzene crosslinker, alkylated between two cysteine residues with different spacings (i, i+4, i, i+7 and i, i+11) and either a rigid or flexible linker domain. In previous studies, basic leucine zipper transcription activators have been photocontrolled in living

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9

Mekala, Vijaya Krishna Wysocka-Diller Joanna. "Isolation and characterization of Scarecrow suppressor mutants in Arabidopsis thaliana." Auburn, Ala, 2008. http://repo.lib.auburn.edu/EtdRoot/2008/FALL/Biological_Sciences/Thesis/Mekala_Vijaya_18.pdf.

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10

Ching, Chi-yun Johannes, and 程子忻. "Transcriptional regulation of p16INK4a expression by the forkhead box transcription factor FOXM1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29466192.

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11

Pinacho, Garcia Raquel. "SP Transcription factors in psychotic disorders." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/327025.

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Psychotic disorders including bipolar disorder and schizophrenia are a leading cause of disability across the world but the underlying pathophysiological mechanisms remain poorly understood. Available treatments are inadequate for some sets of symptoms as is the case for negative symptoms in schizophrenia. Alterations in brain connectivity, synaptic plasticity, N-methyl D aspartate receptor (NMDAR) signalling and calcium homeostasis have been suggested to contribute to these disorders. However, the particular transcriptional programmes altered in these disorders are not fully characterised. Pr

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12

Müller, Susanne. "Transcription factors regulating the Btk promoter /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2717-0.

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13

Paik, Elizabeth Jae-Eun. "Caudal Transcription Factors in Hematopoietic Development." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10254.

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During embryogenesis, hematopoietic cells arise from the lateral plate mesoderm (LPM) following gastrulation. The transcriptional program required for this LPM to blood switch is not fully understood. Previous work on a zebrafish mutant with a deletion in the cdx4 gene demonstrated the importance of this caudal transcription factor in the LPM to blood transition. To explain how cdx4 regulates embryonic hematopoiesis, two main approaches were taken in this thesis. The first part of the thesis describes a chemical genetics screen that identified cdx4 interacting pathways. To find small molecules

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14

Costanzo, Federico. "Role of NER factors in transcription." Thesis, Strasbourg, 2017. http://www.theses.fr/2017STRAJ099.

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Les mutations dans les gènes codant pour les facteurs NER donnent lieu à des maladies autosomiques récessives telles que Xeroderma pigmentosum (XP), le syndrome de Cockayne (CS) et la trichothiodystrophie (TTD). Les phénotypes associés à ces syndromes génétiques se caractérisent par une sensibilité extrême à la lumière UV, avec prédisposition accrue à certains cancers (pour XP et XP / CS combiné, principalement), ainsi qu’un retard mental et des signes de progeria (pour CS et XP / CS combiné). Si on peut admettre une corrélation entre réparation de l'ADN endommagé et sensibilité aux UV / cance

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15

Grossman, Sharon R. (Sharon Rachel). "Combinatorial gene regulation by transcription factors." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/128406.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2019<br>Cataloged from PDF of thesis. "The Table of Contents does not accurately represent the page numbering"--Disclaimer page.<br>Includes bibliographical references.<br>Combinatorial gene regulation is encoded in enhancers and promoters in the form of binding sites for transcription factors (TFs), which collaboratively recruit the transcriptional machinery and drive gene expression. Using high-throughput and quantitative technologies developed by our lab and others, we studied TF binding sites in enhancers from nu

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16

Montelius, Andreas. "Role of transcription factors in sensory neuron specification /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-115-9/.

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17

Jadlowsky, Julie Kendal. "Dual control of HIV transcription elongation virus-specific negative control by NELF-E is counterbalanced by positive transcription factor P-TEFb /." Cleveland, Ohio : Case Western Reserve University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1228234927.

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18

Cusack, Martin. "The role of DNA methylation on transcription factor occupancy and transcriptional activity." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:7d0b7fe7-dee1-433f-8656-c9ee2a216d48.

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DNA methylation is an epigenetic mark that is deposited throughout the genome of mammals and plays an important role in the maintenance of transcriptionally repressive states across cell divisions. There are two major mechanisms by which DNA methylation has been proposed to act: one involves the recognition of the mark by protein complexes containing histone deacetylases (HDACs) that can remodel the local chromatin. Alternatively, methylation has been suggested to directly affect the interaction between transcription factors and their cognate binding sequence. The aim of this research was to d

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19

Li, Yuxin. "The DEC1 transcription factor : oncogenic involvement and molecular mechanisms on transcription regulation /." View online ; access limited to URI, 2003. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3115632.

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20

Eustis, Robyn Lynn. "The Role of Pyrococcus furiosus Transcription Factor E in Transcription Iniitiation." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2522.

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All sequenced archaeal genomes encode a general transcription factor, TFE, which is highly conserved and homologous to the alpha subunit of the eukaryotic transcription factor TFIIE. TFE functions to increase promoter opening efficiency during transcription initiation, although the mechanism for this is unclear. The N-terminus of TFE contains a common DNA binding motif, a winged helix. At the tip of this winged helix is a highly conserved region of aromatic amino acids that is close to DNA during initiation. TFE activation can compensate for mutations in another transcription factor, TFB2, whi

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21

SICILIANO, DILETTA. "ANALYSIS OF THE TRANSCRIPTIONAL REGULATION OF MTORC1 ACTIVITY BY MIT/TFE TRANSCRIPTION FACTORS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/607642.

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The mechanistic Target Of Rapamycin Complex 1 (mTORC1) regulates cellular biosynthetic pathways in response to variations in nutrient availability. Activation of mTORC1 is mediated by Rag GTPases, that act as heterodimers and promote mTORC1 recruitment to the lysosome. Many studies have clarified the post-translational control of mTORC1, but little is known about its transcriptional regulation. Our study demonstrates that TFEB, TFE3 and MITF, members of the MiT/TFE family of transcription factors and master regulators of lysosomal and melanosomal biogenesis and autophagy, are nutrient-sensitiv

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22

Ferguson, Laura A. "The insulin promoter." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25965.

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23

Bhattarai, Arati. "The orientation of the Pyrococcus furiosus transcription factor TFB2 in the transcription initiation complex." PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/1938.

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The hyperthermophile archaeon, Pyrococcus furiosus encodes two eukaryotic TFIIB family proteins, TFB1 and TFB2. TFB1 is very similar to TFIIB in terms of sequence homology and function, whereas TFB2 is unusual as it is missing highly conserved sequences in its N-terminal domain that are present in TFIIB and TFB1. Despite this, TFB2 is effective in transcription process, albeit with lower efficiency compared to TFB1. Other archaea also contain multiple TFBs, but unlike Pyrococcus furiosus TFB2, these multiple TFBs have higher sequence homology to each other and have similar transcription effici

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24

Tai, C. P. Andrew. "An in vivo analysis of specificity of gene transactivation by SOX proteins." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36906438.

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25

Tai, C. P. Andrew, and 戴賜鵬. "An in vivo analysis of specificity of gene transactivation by SOX proteins." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36906438.

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26

Gueroult, bellone Marion. "Signatures nucléotidiques de l'activité des enhancers développementaux chez l'ascidie Ciona intestinalis." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTS029.

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Les enhancers sont des régulateurs cruciaux de l’expression des gènes pendant le développement embryonnaire. L’ascidie Ciona intestinalis est un organisme-modèle qui se prête à l’étude de ces séquences cis-régulatrices car ses enhancers sont généralement petits et compacts, et le lignage invariant des cellules chez l’embryon permet de visualiser leur activité avec une résolution cellulaire. Deux signatures indépendantes associées à l’activité d’un enhancer avaient été identifiées : la présence de sites de fixation pour des facteurs de transcription spécifiques, et une signature dinucléotidique

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27

Castro-Mondragon, Jaime. "Development of bioinformatics methods for the analysis of large collections of transcription factor binding motifs : positional motif enrichment and motif clustering." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0171.

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Les facteurs transcriptionnels (TF) sont des protéines qui contrôlent l'expression des gènes. Leurs motifs de liaison (TFBM, également appelés motifs) sont généralement représentés sous forme de matrices de scores spécifiques de positions (PSSM). L'analyse de motifs est utilisée en routine afin de découvrir des facteurs candidats pour la régulation d'un jeu de séquences d'intérêt. L'avénement des méthodes à haut débit a permis de détecter des centaines de motifs, qui sont disponibles dans des bases de données. Durant ma thèse, j'ai développé deux nouvelles méthodes et implémenté des outils log

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28

Koo, Sonya Janet. "Downstream targets of motor neuron transcription factors /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3190171.

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29

Kinyanjui, Margaret. "Targeting Th2 transcription factors in experimental asthma." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18717.

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Antigen specific CD4+ T cells adoptively transfer airway inflammation comprised mainly of lymphocytes and eosinophils. The ability of these transferred T cells to induce inflammation is dependent on the cytokines they express particularly Th2 cytokines. In order to better understand the mechanism by which adoptively transferred T cells induce airway inflammation, we chose to modulate the expression (GATA-3) and activity (STAT-6) of two key regulators of Th2 cytokine production. To modify expression of GATA-3, we used a bicistronic retroviral vector encoding GATA-3 and enhanced green fluorescen

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30

Ali, Asif. "Transcription factors in parathyroid development and embryology." Thesis, Open University, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489906.

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The roles of two transcription factors, GATA3 and PARAFIBROMIN, that are involved in parathyroid function have been studied. Thus, loss of function mutations of the dual zinc finger transcription factor GATA3 result in hypoparathyroidism-deafness-renal dysplasia (HDR) syndrome; whilst loss of function mutations of PARAFIBROMIN which is a nuclear protein with a likely role in the RNA polymerase complex, lead to the hyperparathyroidism-jaw tumour (HPT-JT) syndrome.

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31

Young, Neville Jonathan. "The role of transcription factors in odontogenesis." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393692.

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32

Friedrich, Dhana. "Oscillatory transcription factors and stochastic gene expression." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/22053.

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Transkriptionsfaktoren (TFs) empfangen Signale in Signaltransduktionskaskaden und übersetzen diese in eine zelluläre Antwort. Dadurch ermöglichen sie es Zellen, Organen und Organismen sich an verändernde Umgebungsbedingungen anzupassen. In früheren Studien wurde gezeigt, dass viele TFs nach Aktivierung Oszillationen im Zellkern aufweisen. Ein Beispiel dafür ist p53. Als zentrales Protein im Rahmen der zellulären Stressantwort reguliert es nach DNA Schaden die Expression hunderter Zielgene die das Zellschicksal steuern. Anomalien in der Aktivität von p53 stehen im Zusammenhang mit schwerwiegend

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33

Gillis, William Joseph. "The evolution of metazoan GATA transcription factors /." Connect to title online (Scholars' Bank) Connect to title online (ProQuest), 2008. http://hdl.handle.net/1794/8568.

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Thesis (Ph. D.)--University of Oregon, 2008.<br>Typescript. Includes vita and abstract. "This dissertation includes both ... previously published and unpublished co-authored material"--P. v. Includes bibliographical references (leaves 120-135). Also available online in Scholars' Bank; and in ProQuest, free to University of Oregon users.

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34

Gillis, William Joseph 1981. "The evolution of metazoan GATA transcription factors." Thesis, University of Oregon, 2008. http://hdl.handle.net/1794/8568.

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xiii, 135 p. ; ill. (some col.) A print copy of this title is available through the UO Libraries. Search the library catalog for the location and call number.<br>This thesis explores the origin and evolution of animal germ layers via evolutionary-developmental analyses of the GATA family of transcription factors. GATA factors identified via a conserved dual zinc-finger domain direct early germ layer specification across a wide variety of animals. However, most of these developmental roles are characterized in invertebrate models, whose rapidly evolved sequences make it difficult to reconstruct

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35

Kiosses, Theodore. "DNA binding specificity and transcriptional regulation of Six4 : a myotonic dystrophy associated transcription factor." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3948.

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Attaining an understanding of the mechanisms underpinning development has been amongst the cardinal scientific challenges of our age. The transition from a single cell organism to the level of complexity evidenced in higher eukaryotes has been facilitated by the advent of intricate developmental networks involving a plethora of factors that synergise to allow for precise spatio-temporal expression of the proteins present in higher organisms. Development is often portrayed as a domino like cascade of events stemming from relatively uncomplicated origins that go on to branch out and form associa

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36

Roberts, Karen. "Regulation of melanocyte-specific transcription by the transcription factors BRN-2 and microphthalmia." Thesis, Institute of Cancer Research (University Of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286144.

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37

Jahangiri, Leila. "Combinatorial gene regulation by T-domain transcription factors." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610328.

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38

Ferrara, Giovanni Antonio. "Studies of transcriptional regulation by the vitamin D3 receptor and cAMP-responsive transcription factors." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69734.

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Cells of complex organisms communicate with each other by sending molecular signals. These signals can be classified by their solubility properties. Hydrophilic signals, in the form of peptides or small hydrophilic molecules, interact with extracellular receptors located on the surface of target cells. Binding of ligand to its receptor leads to transduction of an intracellular signal via a second messenger. Lipophilic signals (steroids, vitamin D$ sb3$, thyroid hormone, and retinoids) traverse the plasma membrane and bind to specific intracellular proteins, known collectively as nuclear recept

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39

Immarigeon, Clément. "Role of mediator complex subunits in transcriptional regulation by GATA and FOG transcription factors during Drosophila development." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2654/.

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Un enjeu majeur en Biologie est de comprendre comment les milliers de gènes composant le génome sont contrôlés afin d'être exprimés dans les bonnes cellules au bon moment. Cette régulation a lieu en grande partie à l'étape de pré-initiation de la transcription. Ce processus résulte de l'action concertée de nombreuses protéines, dont le complexe Médiateur (MED, ~30 sous-unités protéiques ou SU, >1,5MDa) qui joue un rôle conservé dans la régulation de la transcription des gènes par l'ARN Polymérase II (PolII), de la levure à l'Homme. Ce complexe se lie simultanément à la PolII et aux facteurs

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40

Ranish, Jeffrey A. "Mechanisms of transcription by RNA Polymerase II /." Thesis, Connect to this title online; UW restricted, 1999. http://hdl.handle.net/1773/5057.

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41

Yang, Shu, and 杨澍. "Co-evolution of transcription factors and their binding sites." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46339863.

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42

Vaidya, Harsh Jayeshkumar. "Investigation of transcriptional regulation of Foxn1 in fetal thymic epithelial progenitor cells." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/21697.

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The thymus in mice and humans originates from the third pharyngeal pouch endoderm. This process is divided into early Foxn1-independent stages and later Foxn1-dependent stages. Foxn1 is indispensible for the differentiation of thymic epithelial progenitor cells (TEPCs) as the development of thymus in Foxn1 mutant mice is arrested around E12.5. The transcriptional changes associated with the developmental of the thymus are poorly understood. In particular, the transcriptional regulation of Foxn1 in the developing thymic rudiment has not been definitively identified. Recently, Pax1, Pax9, Tbx1,

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43

Sites, Emily. "Proposed Roles for Sox Transcription Factors and Growth Factor Receptors in NF1." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1226071241.

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44

Sheffield, Kimberly Kay. "Interplay of Transcription Factor E and Spt4/5 During Transcription Initiation in Pyrococcus furiosus." PDXScholar, 2018. https://pdxscholar.library.pdx.edu/open_access_etds/4444.

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Transcription, the first step in gene expression, is a highly regulated process which relies on a multi-protein complex to occur. Among these proteins are transcription factors, including initiation and elongation factors, which play differing roles in early and late stages of transcription. The mechanisms of transition from transcription initiation to elongation are not well understood in archaea, nor are the structures of the transcription factors involved. For transcription to occur in vitro, transcription factors TATA binding protein (TBP) and Transcription Factor B (TFB) are sufficient to

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45

何明孝 and Ming-how Ho. "Sequence variation and covariation in forkhead domains." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970552.

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46

Ho, Ming-how. "Sequence variation and covariation in forkhead domains." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25155283.

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47

Pang, Ting-kai Ronald. "Transcriptional regulation of the human secretin receptor gene /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25059324.

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48

Zhou, Shengli. "ZNF451 is a novel binding partner of the bHLH transcription factor E₁₂." Connect to full text in OhioLINK ETD Center, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=mco1225219996.

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Thesis (M.S.)--University of Toledo, 2008.<br>"In partial fulfillment of the requirements for the degree of Master of Science in Biomedical Sciences." Title from title page of PDF document. Bibliography: pages 49-62.

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49

Viart, Victoria. "Etude de la régulation transcriptionnelle et post-transcriptionnelle du gène CFTR : identification de facteurs de transcription et de microARNs." Thesis, Montpellier 1, 2011. http://www.theses.fr/2011MON1T031/document.

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Le gène CFTR, impliqué lorsqu'il est muté dans la mucoviscidose, est finement régulé au niveau tissulaire (principalement exprimé dans les organes cibles de la mucoviscidose) et au cours du développement. Par exemple, dans les tissus pulmonaires, l'expression du gène CFTR est plus forte chez le fœtus que chez l'adulte (75:1), où seulement deux copies en moyenne par cellule sont détectées.L'objectif de ce travail était de déterminer les mécanismes moléculaires responsables de cette régulation. Nous avons identifié de nombreux motifs cis-régulateurs au niveau de la région promotrice et de la rég

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50

Towers, Terri L. "Vitamin D3-mediated transcriptional repression : of the granulocyte-macrophage colony stimulating factor gene /." Access full-text from WCMC, 1998. http://proquest.umi.com/pqdweb?did=733066141&sid=3&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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