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Journal articles on the topic 'Transcription factors'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Wilson, Nicola K., Fernando J. Calero-Nieto, Rita Ferreira, and Berthold Göttgens. "Transcriptional regulation of haematopoietic transcription factors." Stem Cell Research & Therapy 2, no. 1 (2011): 6. http://dx.doi.org/10.1186/scrt47.

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2

Geng, Yanbiao, Peter Laslo, Kevin Barton, and Chyung-Ru Wang. "Transcriptional Regulation ofCD1D1by Ets Family Transcription Factors." Journal of Immunology 175, no. 2 (2005): 1022–29. http://dx.doi.org/10.4049/jimmunol.175.2.1022.

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3

Senecal, Adrien, Brian Munsky, Florence Proux, et al. "Transcription Factors Modulate c-Fos Transcriptional Bursts." Cell Reports 8, no. 1 (2014): 75–83. http://dx.doi.org/10.1016/j.celrep.2014.05.053.

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4

BARNES, P. J., and I. M. ADCOCK. "Transcription factors." Clinical Experimental Allergy 25, s2 (1995): 46–49. http://dx.doi.org/10.1111/j.1365-2222.1995.tb00421.x.

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5

Hawkins, R. "Transcription Factors." Journal of Medical Genetics 33, no. 12 (1996): 1054. http://dx.doi.org/10.1136/jmg.33.12.1054-a.

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6

Papavassiliou, Athanasios G. "Transcription Factors." New England Journal of Medicine 332, no. 1 (1995): 45–47. http://dx.doi.org/10.1056/nejm199501053320108.

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7

Locker, J. "Transcription Factors." Biomedicine & Pharmacotherapy 52, no. 1 (1998): 47. http://dx.doi.org/10.1016/s0753-3322(97)86247-6.

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8

Locker., J. "Transcription Factors." Journal of Steroid Biochemistry and Molecular Biology 64, no. 5-6 (1998): 316. http://dx.doi.org/10.1016/s0960-0760(96)00245-2.

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9

Handel, Malcolm L., and Laila Girgis. "Transcription factors." Best Practice & Research Clinical Rheumatology 15, no. 5 (2001): 657–75. http://dx.doi.org/10.1053/berh.2001.0186.

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10

Parker, C. S. "Transcription factors." Current Opinion in Cell Biology 1, no. 3 (1989): 512–18. http://dx.doi.org/10.1016/0955-0674(89)90013-6.

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11

Zhang, Yuli, and Linlin Hou. "Alternate Roles of Sox Transcription Factors beyond Transcription Initiation." International Journal of Molecular Sciences 22, no. 11 (2021): 5949. http://dx.doi.org/10.3390/ijms22115949.

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Sox proteins are known as crucial transcription factors for many developmental processes and for a wide range of common diseases. They were believed to specifically bind and bend DNA with other transcription factors and elicit transcriptional activation or repression activities in the early stage of transcription. However, their functions are not limited to transcription initiation. It has been showed that Sox proteins are involved in the regulation of alternative splicing regulatory networks and translational control. In this review, we discuss the current knowledge on how Sox transcription f

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12

Bloor, Adrian, Ekaterina Kotsopoulou, Penny Hayward, Brian Champion, and Anthony Green. "RFP represses transcriptional activation by bHLH transcription factors." Oncogene 24, no. 45 (2005): 6729–36. http://dx.doi.org/10.1038/sj.onc.1208828.

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13

Zhang, Lang, Haoyue Yu, Pan Wang, Qingyang Ding, and Zhao Wang. "Screening of transcription factors with transcriptional initiation activity." Gene 531, no. 1 (2013): 64–70. http://dx.doi.org/10.1016/j.gene.2013.07.054.

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14

Thiel, Gerald, Lisbeth A. Guethlein, and Oliver G. Rössler. "Insulin-Responsive Transcription Factors." Biomolecules 11, no. 12 (2021): 1886. http://dx.doi.org/10.3390/biom11121886.

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The hormone insulin executes its function via binding and activating of the insulin receptor, a receptor tyrosine kinase that is mainly expressed in skeletal muscle, adipocytes, liver, pancreatic β-cells, and in some areas of the central nervous system. Stimulation of the insulin receptor activates intracellular signaling cascades involving the enzymes extracellular signal-regulated protein kinase-1/2 (ERK1/2), phosphatidylinositol 3-kinase, protein kinase B/Akt, and phospholipase Cγ as signal transducers. Insulin receptor stimulation is correlated with multiple physiological and biochemical f

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15

Yamada, Yasuyuki, and Fumihiko Sato. "Transcription Factors in Alkaloid Engineering." Biomolecules 11, no. 11 (2021): 1719. http://dx.doi.org/10.3390/biom11111719.

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Plants produce a large variety of low-molecular-weight and specialized secondary compounds. Among them, nitrogen-containing alkaloids are the most biologically active and are often used in the pharmaceutical industry. Although alkaloid chemistry has been intensively investigated, characterization of alkaloid biosynthesis, including biosynthetic enzyme genes and their regulation, especially the transcription factors involved, has been relatively delayed, since only a limited number of plant species produce these specific types of alkaloids in a tissue/cell-specific or developmental-specific man

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16

Bakshi, Madhunita, and Ralf Oelmüller. "WRKY transcription factors." Plant Signaling & Behavior 9, no. 2 (2014): e27700. http://dx.doi.org/10.4161/psb.27700.

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17

Massague, J. "Smad transcription factors." Genes & Development 19, no. 23 (2005): 2783–810. http://dx.doi.org/10.1101/gad.1350705.

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18

Steinke, John, and Larry Borish. "Beyond Transcription Factors." Allergy & Clinical Immunology International - Journal of the World Allergy Organization 16, no. 01 (2004): 20–27. http://dx.doi.org/10.1027/0838-1925.16.1.20.

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19

Engelkamp, Dieter. "Pathological transcription factors." Trends in Genetics 16, no. 5 (2000): 233–34. http://dx.doi.org/10.1016/s0168-9525(99)01963-0.

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20

Yeh, Jennifer E., Patricia A. Toniolo, and David A. Frank. "Targeting transcription factors." Current Opinion in Oncology 25, no. 6 (2013): 652–58. http://dx.doi.org/10.1097/01.cco.0000432528.88101.1a.

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21

Wolffe, A. "Architectural transcription factors." Science 264, no. 5162 (1994): 1100–1101. http://dx.doi.org/10.1126/science.8178167.

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22

Rushton, Paul J., Imre E. Somssich, Patricia Ringler, and Qingxi J. Shen. "WRKY transcription factors." Trends in Plant Science 15, no. 5 (2010): 247–58. http://dx.doi.org/10.1016/j.tplants.2010.02.006.

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23

Warren, Alan J. "Eukaryotic transcription factors." Current Opinion in Structural Biology 12, no. 1 (2002): 107–14. http://dx.doi.org/10.1016/s0959-440x(02)00296-8.

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24

Tan, Song, and Timothy J. Richmond. "Eukaryotic transcription factors." Current Opinion in Structural Biology 8, no. 1 (1998): 41–48. http://dx.doi.org/10.1016/s0959-440x(98)80008-0.

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25

Reese, Joseph C. "Basal transcription factors." Current Opinion in Genetics & Development 13, no. 2 (2003): 114–18. http://dx.doi.org/10.1016/s0959-437x(03)00013-3.

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26

Wolberger, Cynthia. "Combinatorial transcription factors." Current Opinion in Genetics & Development 8, no. 5 (1998): 552–59. http://dx.doi.org/10.1016/s0959-437x(98)80010-5.

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27

Struhl, Kevin. "Yeast transcription factors." Current Opinion in Cell Biology 5, no. 3 (1993): 513–20. http://dx.doi.org/10.1016/0955-0674(93)90018-l.

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28

Crunkhorn, Sarah. "Targeting transcription factors." Nature Reviews Drug Discovery 18, no. 1 (2018): 18. http://dx.doi.org/10.1038/nrd.2018.231.

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29

D'Arcangelo, Gabriel la, and Tom Curran. "Smart transcription factors." Nature 376, no. 6538 (1995): 292–93. http://dx.doi.org/10.1038/376292a0.

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30

Latchman, D. S. "Eukaryotic transcription factors." Biochemical Journal 270, no. 2 (1990): 281–89. http://dx.doi.org/10.1042/bj2700281.

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31

Latchman, David S. "Inhibitory transcription factors." International Journal of Biochemistry & Cell Biology 28, no. 9 (1996): 965–74. http://dx.doi.org/10.1016/1357-2725(96)00039-8.

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32

Carter, Matthew E., and Anne Brunet. "FOXO transcription factors." Current Biology 17, no. 4 (2007): R113—R114. http://dx.doi.org/10.1016/j.cub.2007.01.008.

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33

Polyanovsky, Oleg L., and Alexander G. Stepchenko. "Eukaryotic transcription factors." BioEssays 12, no. 5 (1990): 205–10. http://dx.doi.org/10.1002/bies.950120503.

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34

Poulat, Francis. "Non-Coding Genome, Transcription Factors, and Sex Determination." Sexual Development 15, no. 5-6 (2021): 295–307. http://dx.doi.org/10.1159/000519725.

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In vertebrates, gonadal sex determination is the process by which transcription factors drive the choice between the testicular and ovarian identity of undifferentiated somatic progenitors through activation of 2 different transcriptional programs. Studies in animal models suggest that sex determination always involves sex-specific transcription factors that activate or repress sex-specific genes. These transcription factors control their target genes by recognizing their regulatory elements in the non-coding genome and their binding motifs within their DNA sequence. In the last 20 years, the

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35

Chávez, Joselyn, Damien P. Devos, and Enrique Merino. "Complementary Tendencies in the Use of Regulatory Elements (Transcription Factors, Sigma Factors, and Riboswitches) in Bacteria and Archaea." Journal of Bacteriology 203, no. 2 (2020): e00413-20. http://dx.doi.org/10.1128/jb.00413-20.

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ABSTRACTIn prokaryotes, the key players in transcription initiation are sigma factors and transcription factors that bind to DNA to modulate the process, while premature transcription termination at the 5′ end of the genes is regulated by attenuation and, in particular, by attenuation associated with riboswitches. In this study, we describe the distribution of these regulators across phylogenetic groups of bacteria and archaea and find that their abundance not only depends on the genome size, as previously described, but also varies according to the phylogeny of the organism. Furthermore, we o

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36

Becskei, Attila. "Tuning up Transcription Factors for Therapy." Molecules 25, no. 8 (2020): 1902. http://dx.doi.org/10.3390/molecules25081902.

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The recent developments in the delivery and design of transcription factors put their therapeutic applications within reach, exemplified by cell replacement, cancer differentiation and T-cell based cancer therapies. The success of such applications depends on the efficacy and precision in the action of transcription factors. The biophysical and genetic characterization of the paradigmatic prokaryotic repressors, LacI and TetR and the designer transcription factors, transcription activator-like effector (TALE) and CRISPR-dCas9 revealed common principles behind their efficacy, which can aid the

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37

WATANABE, A., M. ARAI, N. KOITABASHI, M. YAMAZAKI, K. NIWANO, and M. KURABAYASHI. "Mitochondrial transcription factors regulate SERCA2 gene transcription." Journal of Molecular and Cellular Cardiology 41, no. 6 (2006): 1049. http://dx.doi.org/10.1016/j.yjmcc.2006.08.046.

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38

Pan, Yanyun, Jin Dai, Minwei Jin, Qiujun Zhou, Xiaoliang Jin, and Jinjie Zhang. "Transcription factors in tanshinones: Emerging mechanisms of transcriptional regulation." Medicine 103, no. 47 (2024): e40343. http://dx.doi.org/10.1097/md.0000000000040343.

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Transcription factors play a crucial role in the biosynthesis of tanshinones, which are significant secondary metabolites derived from Salvia miltiorrhiza, commonly known as Danshen. These compounds have extensive pharmacological properties, including anti-inflammatory and cardioprotective effects. This review delves into the roles of various transcription factor families, such as APETALA2/ethylene response factor, basic helix-loop-helix, myeloblastosis, basic leucine zipper, and WRKY domain-binding protein, in regulating the biosynthetic pathways of tanshinones. We discuss the emerging mechan

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39

Gao, T. W., W. W. Zhang, A. P. Song, et al. "Phylogenetic and transcriptional analysis of chrysanthemum GRAS transcription factors." Biologia Plantarum 62, no. 4 (2018): 711–20. http://dx.doi.org/10.1007/s10535-018-0816-1.

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40

Fox, Rebecca M., and Deborah J. Andrew. "Transcriptional regulation of secretory capacity by bZip transcription factors." Frontiers in Biology 10, no. 1 (2014): 28–51. http://dx.doi.org/10.1007/s11515-014-1338-7.

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41

Hampsey, Michael. "Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery." Microbiology and Molecular Biology Reviews 62, no. 2 (1998): 465–503. http://dx.doi.org/10.1128/mmbr.62.2.465-503.1998.

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SUMMARY Transcription initiation by RNA polymerase II (RNA pol II) requires interaction between cis-acting promoter elements and trans-acting factors. The eukaryotic promoter consists of core elements, which include the TATA box and other DNA sequences that define transcription start sites, and regulatory elements, which either enhance or repress transcription in a gene-specific manner. The core promoter is the site for assembly of the transcription preinitiation complex, which includes RNA pol II and the general transcription fctors TBP, TFIIB, TFIIE, TFIIF, and TFIIH. Regulatory elements bin

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42

Cai, Bin, Cheng-Hui Li, Ai-Sheng Xiong, et al. "DGTF: A Database of Grape Transcription Factors." Journal of the American Society for Horticultural Science 133, no. 3 (2008): 459–61. http://dx.doi.org/10.21273/jashs.133.3.459.

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The database of grape transcription factors (DGTF) is a plant transcription factor (TF) database comprehensively collecting and annotating grape (Vitis L.) TF. The DGTF contains 1423 putative grape TF in 57 families. These TF were identified from the predicted wine grape (Vitis vinifera L.) proteins from the grape genome sequencing project by means of a domain search. The DGTF provides detailed annotations for individual members of each TF family, including sequence feature, domain architecture, expression information, and orthologs in other plants. Cross-links to other public databases make i

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43

Fuhrken, Peter G., Chi Chen, Pani A. Apostolidis, Min Wang, William M. Miller, and Eleftherios T. Papoutsakis. "Gene Ontology-driven transcriptional analysis of CD34+cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis." Physiological Genomics 33, no. 2 (2008): 159–69. http://dx.doi.org/10.1152/physiolgenomics.00127.2007.

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Differentiation of hematopoietic stem and progenitor cells is an intricate process controlled in large part at the level of transcription. While some key megakaryocytic transcription factors have been identified, the complete network of megakaryocytic transcriptional control is poorly understood. Using global gene expression microarray analysis, Gene Ontology-based functional annotations, and a novel interlineage comparison with parallel, isogenic granulocytic cultures as a negative control, we closely examined the mRNA level of transcriptional regulators in megakaryocytes derived from human m

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44

Shih, H. M., C. C. Chang, H. Y. Kuo, and D. Y. Lin. "Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization." Biochemical Society Transactions 35, no. 6 (2007): 1397–400. http://dx.doi.org/10.1042/bst0351397.

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SUMO (small ubiquitin-related modifier) modification is emerging as an important post-translational control in transcription. In general, SUMO modification is associated with transcriptional repression. Although many SUMO-modified transcription factors and co-activators have been identified, little is known about the mechanism underlying SUMOylation-elicited transcriptional repression. Here, we summarize that SUMO modification of transcription factors such as androgen receptor, glucocorticoid receptor, Smad4 and CBP [CREB (cAMP-response-element-binding protein)-binding protein] co-activator re

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45

Seo, Hyungseok, Joyce Chen, Edahí González-Avalos, et al. "TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion." Proceedings of the National Academy of Sciences 116, no. 25 (2019): 12410–15. http://dx.doi.org/10.1073/pnas.1905675116.

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T cells expressing chimeric antigen receptors (CAR T cells) have shown impressive therapeutic efficacy against leukemias and lymphomas. However, they have not been as effective against solid tumors because they become hyporesponsive (“exhausted” or “dysfunctional”) within the tumor microenvironment, with decreased cytokine production and increased expression of several inhibitory surface receptors. Here we define a transcriptional network that mediates CD8+ T cell exhaustion. We show that the high-mobility group (HMG)-box transcription factors TOX and TOX2, as well as members of the NR4A famil

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46

Granadino, B., C. Perez-Sanchez, and J. Rey-Campos. "Fork Head Transcription Factors." Current Genomics 1, no. 4 (2000): 353–82. http://dx.doi.org/10.2174/1389202003351319.

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47

IMAGAWA, Masayoshi. "Transcription Factors in Eukaryotes." Seibutsu Butsuri 33, no. 3 (1993): 154–58. http://dx.doi.org/10.2142/biophys.33.154.

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48

Wilanowski, Tomasz, and Sebastian Dworkin. "Transcription Factors in Cancer." International Journal of Molecular Sciences 23, no. 8 (2022): 4434. http://dx.doi.org/10.3390/ijms23084434.

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49

Rusk, Nicole. "Transcription factors without footprints." Nature Methods 11, no. 10 (2014): 988–89. http://dx.doi.org/10.1038/nmeth.3128.

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50

Williams, Ruth. "Imaging individual transcription factors." Journal of Cell Biology 177, no. 6 (2007): 946a. http://dx.doi.org/10.1083/jcb.1776rr1.

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