Relevant bibliographies by topics / Transcription regulation model

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Transcription regulation model'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Transcription regulation model"

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Geng, Yuncong, Christopher Herrick Bohrer, Nicolás Yehya, et al. "A spatially resolved stochastic model reveals the role of supercoiling in transcription regulation." PLOS Computational Biology 18, no. 9 (2022): e1009788. http://dx.doi.org/10.1371/journal.pcbi.1009788.

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In Escherichia coli, translocation of RNA polymerase (RNAP) during transcription introduces supercoiling to DNA, which influences the initiation and elongation behaviors of RNAP. To quantify the role of supercoiling in transcription regulation, we developed a spatially resolved supercoiling model of transcription. The integrated model describes how RNAP activity feeds back with the local DNA supercoiling and how this mechanochemical feedback controls transcription, subject to topoisomerase activities and stochastic topological domain formation. This model establishes that transcription-induced
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Asada, Ryuta, and Kouji Hirota. "Multi-Layered Regulations on the Chromatin Architectures: Establishing the Tight and Specific Responses of Fission Yeast fbp1 Gene Transcription." Biomolecules 12, no. 11 (2022): 1642. http://dx.doi.org/10.3390/biom12111642.

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Transcriptional regulation is pivotal for all living organisms and is required for adequate response to environmental fluctuations and intercellular signaling molecules. For precise regulation of transcription, cells have evolved regulatory systems on the genome architecture, including the chromosome higher-order structure (e.g., chromatin loops), location of transcription factor (TF)-binding sequences, non-coding RNA (ncRNA) transcription, chromatin configuration (e.g., nucleosome positioning and histone modifications), and the topological state of the DNA double helix. To understand how thes
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Carrera, Javier, Guillermo Rodrigo, and Alfonso Jaramillo. "Model-based redesign of global transcription regulation." Nucleic Acids Research 37, no. 5 (2009): e38-e38. http://dx.doi.org/10.1093/nar/gkp022.

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MJOLSNESS, ERIC. "ON COOPERATIVE QUASI-EQUILIBRIUM MODELS OF TRANSCRIPTIONAL REGULATION." Journal of Bioinformatics and Computational Biology 05, no. 02b (2007): 467–90. http://dx.doi.org/10.1142/s0219720007002874.

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Mechanistic models for transcriptional regulation are derived using the methods of equilibrium statistical mechanics, to model equilibrating processes that occur at a fast time scale. These processes regulate slower changes in the synthesis and expression of transcription factors that feed back and cooperatively regulate transcription, forming a gene regulation network (GRN). We rederive and extend two previous quasi-equilibrium models of transcriptional regulation, and demonstrate circumstances under which they can be approximated at each transcription complex by feed-forward artificial neura
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Akberdin, I. R., A. Yu Vertyshev, S. S. Pintus, D. V. Popov, and F. A. Kolpakov. "A Mathematical Model Linking Ca2+-Dependent Signaling Pathway and Gene Expression Regulation in Human Skeletal Muscle." Mathematical Biology and Bioinformatics 15, no. 1 (2020): 20–39. http://dx.doi.org/10.17537/2020.15.20.

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The physiological adaptation to aerobic endurance exercises is provided by activation of signaling pathways in skeletal muscle cells. Training-induced activation of specific signaling pathways results in significant transcriptional responses. Despite the ongoing endeavours to experimentally investigate regulatory mechanisms and signal transduction pathways involved in the contraction-induced adaptation, quantitative contribution of certain signal molecules in expression regulation of genes responsible for intracellular response has not been studied comprehensively yet. The paper presents novel
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Jackson, Kelly A., Ruth A. Valentine, Lisa J. Coneyworth, John C. Mathers, and Dianne Ford. "Mechanisms of mammalian zinc-regulated gene expression." Biochemical Society Transactions 36, no. 6 (2008): 1262–66. http://dx.doi.org/10.1042/bst0361262.

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Mechanisms through which gene expression is regulated by zinc are central to cellular zinc homoeostasis. In this context, evidence for the involvement of zinc dyshomoeostasis in the aetiology of diseases, including Type 2 diabetes, Alzheimer's disease and cancer, highlights the importance of zinc-regulated gene expression. Mechanisms elucidated in bacteria and yeast provide examples of different possible modes of zinc-sensitive gene regulation, involving the zinc-regulated binding of transcriptional activators and repressors to gene promoter regions. A mammalian transcriptional regulatory mech
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Murray, Philip J., Eleonore Ocana, Hedda A. Meijer, and Jacqueline Kim Dale. "Auto-Regulation of Transcription and Translation: Oscillations, Excitability and Intermittency." Biomolecules 11, no. 11 (2021): 1566. http://dx.doi.org/10.3390/biom11111566.

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Several members of the Hes/Her family, conserved targets of the Notch signalling pathway, encode transcriptional repressors that dimerise, bind DNA and self-repress. Such autoinhibition of transcription can yield homeostasis and, in the presence of delays that account for processes such as transcription, splicing and transport, oscillations. Whilst previous models of autoinhibition of transcription have tended to treat processes such as translation as being unregulated (and hence linear), here we develop and explore a mathematical model that considers autoinhibition of transcription together w
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TUĞRUL, MURAT, and ALKAN KABAKÇIOĞLU. "ROBUSTNESS OF TRANSCRIPTIONAL REGULATION IN YEAST-LIKE MODEL BOOLEAN NETWORKS." International Journal of Bifurcation and Chaos 20, no. 03 (2010): 929–35. http://dx.doi.org/10.1142/s0218127410026228.

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We investigate the dynamical properties of the transcriptional regulation of gene expression in the yeast Saccharomyces Cerevisiae within the framework of a synchronously and deterministically updated Boolean network model. With a dynamically determinant subnetwork, we explore the robustness of transcriptional regulation as a function of the type of Boolean functions used in the model that mimic the influence of regulating agents on the transcription level of a gene. We compare the results obtained for the actual yeast network with those from two different model networks, one with similar in-d
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Huang, Gang, Shannon Elf, Xiaomei Yan, et al. "Previously Unknown Interactions Between AML1 and MLL Provide Epigenetic Regulation of Gene Expression in Normal Hematopoiesis and in Leukemia." Blood 112, no. 11 (2008): 282. http://dx.doi.org/10.1182/blood.v112.11.282.282.

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Abstract In all organisms, the fundamental process of transcriptional regulation requires transcription factors, which bind to DNA in response to extra-cellular signals and regulate transcription of target genes. In eukaryotes, this process also involves epigenetic regulation, which includes DNA and histone modifications. Hematopoiesis and leukemia are excellent model systems for studying the higher eukaryotic regulations of gene expression and for identifying important molecules involved in genetic and epigenetic transcriptional regulation. The Mixed-Lineage Leukemia (MLL) protein, a Set1-lik
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Ahmed, Mahmoud, Trang Huyen Lai, Trang Minh Pham, et al. "Hierarchical regulation of autophagy during adipocyte differentiation." PLOS ONE 17, no. 1 (2022): e0250865. http://dx.doi.org/10.1371/journal.pone.0250865.

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We previously showed that some adipogenic transcription factors such as CEBPB and PPARG directly and indirectly regulate autophagy gene expression in adipogenesis. The order and effect of these events are undetermined. In this study, we modeled the gene expression, DNA-binding of transcriptional regulators, and histone modifications during adipocyte differentiation and evaluated the effect of the regulators on gene expression in terms of direction and magnitude. Then, we identified the overlap of the transcription factors and co-factors binding sites and targets. Finally, we built a chromatin
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Dissertations / Theses on the topic "Transcription regulation model"

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Dunham, Lee. "Dynamic regulation of growth hormone gene transcription." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/dynamic-regulation-of-growth-hormone-gene-transcription(62354b9b-c755-43b6-a3f0-d108c32232c9).html.

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Many genes demonstrate highly dynamic pulsatile expression, with characteristic bursts of activity. Dynamic expression of the human prolactin (hPrl) gene in pituitary cells has previously been investigated identifying key temporal characteristics, influenced by the process of chromatin remodelling. Earlier work on the related pituitary human growth hormone (hGH) proximal promoter (-496/+1bp) indicated that it displayed similar dynamic behaviour. The human GH gene contains an extensive long-distance regulatory sequence, including a locus control region (-14/-32kbp) that has been shown to regula
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Amiott, Elizabeth Anne. "A model for the carbon source regulation of yeast mitochondrial transcription /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 100-113). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
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Lloréns, Rico Verónica 1989. "Integrative understanding of transcription in a minimal cell model." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/459003.

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One of the major challenges of biology is to understand how entire cells or organisms behave in homeostasis and in response to perturbations. Whole-cell modeling promotes this understanding by integrating different cellular processes in a single model that is able to predict emergent cellular behaviors. In this thesis, we have developed the first whole-cell model of the genome-reduced bacterium Mycoplasma pneumoniae, which encodes for less than 700 protein-coding genes. This model follows the structure of the previously described model in Mycoplasma genitalium. However, the lack of comprehensi
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Ilsley, Garth Robert. "A statistical model relating transcription factor concentrations to positional information in the early Drosophila embryo." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/236115.

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The idea of morphogen gradients encoding positional information for a developing organism has long been discussed in the field of developmental biology, but only recently have quantitative models been proposed that relate measured transcription factor concentrations to enhancer activity. However, successful models are typically computationally time-consuming, thus limiting full exploration and interpretation of the data. This thesis addresses these problems using standard statistical techniques applied to a comprehensive data set with the even skipped (eve) locus as a test case. The first part
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Thompson, Dorothea Kathleen. "Regulation of gene transcription in the archaeon haloferax volcanii using the heat shock response as a model system /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487948807587033.

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Andersson, Patrik. "Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-469-0/.

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Ozolins, Terence Robert Stanislavs. "Regulation of the transcription factor activator protein-1 (AP-1) in the whole rat embryo culture model in response to oxidative stress." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0015/NQ44545.pdf.

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Kuo, Yen-Ping. "In vivo characterization of archaeal transcription termination signals, and, characterization of a Haloferax volcanii heat shock gene: A model for gene regulation /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487945015616366.

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Kennedy, Brian Alexander. "Developing the Cis-Regulatory Association Model (CRAM) to Identify Combinations of Transcription Factors in ChIP-Seq Data." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1291138540.

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Zonta, Eleonora. "Implications of RNA helicases ddx5 (p68) and ddx17 (p72) in alternative splicing regulation and mRNA export in a mammary tumor model." Paris 7, 2012. http://www.theses.fr/2012PA077104.

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Les ARN hélicases ddx5 (p68) et ddx17 (p72) sont deux protéines multifonctionnelles très similaires connues pour jouer un rôle dans la transcription comme co-régulateurs de divers facteurs de transcription, dans la maturation des miARNs et des mARNs, en particulier dans l'épissage. Il a été également montré que ces deux hélicases sont impliquées dans le développement et dans différents types de cancers. Afin de mieux comprendre les mécanismes par lesquels ddx5 et ddx17 contrôlent l'expression génique, j'ai dans un premier temps examiné le rôle de ddx5 dans la régulation de c-fos, un gène cible
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Books on the topic "Transcription regulation model"

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Jeffrey, Wilusz, ed. Post-transcriptional gene regulation. Humana Press, 2008.

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Wilusz, Jeffrey. Post-Transcriptional Gene Regulation. Humana Press, 2010.

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Book chapters on the topic "Transcription regulation model"

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Muley, Vijaykumar Yogesh. "Mathematical Linear Programming to Model MicroRNAs-Mediated Gene Regulation Using Gurobi Optimizer." In Modeling Transcriptional Regulation. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1534-8_19.

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Spelsberg, T. C., M. Horton, K. Fink, et al. "A NEW MODEL FOR STEROID REGULATION OF GENE TRANSCRIPTION USING CHROMATIN ACCEPTOR SITES AND REGULATORY GENES AND THEIR PRODUCTS." In Recent Advances in Steroid Hormone Action, edited by V. K. Moudgil. De Gruyter, 1987. http://dx.doi.org/10.1515/9783110850260-003.

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Thormann, Verena, Marina Borschiwer, and Sebastiaan H. Meijsing. "Transcriptional Regulation: When 1+1≠2." In Dynamics of Mathematical Models in Biology. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-45723-9_1.

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Raveh-Sadka, Tali, Michal Levo, and Eran Segal. "Incorporating Nucleosomes into Thermodynamic Models of Transcription Regulation." In Lecture Notes in Computer Science. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02008-7_15.

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Lawrence, Neil, Magnus Rattray, Antti Honkela, and Michalis Titsias. "Gaussian Process Inference for Differential Equation Models of Transcriptional Regulation." In Handbook of Statistical Systems Biology. John Wiley & Sons, Ltd, 2011. http://dx.doi.org/10.1002/9781119970606.ch19.

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DeWitt, David L., Stacey A. Kraemer, and Elizabeth A. Meade. "A Model for the Transcriptional Regulation of a Mouse PGH Synthase Gene." In Prostaglandins, Leukotrienes, Lipoxins, and PAF. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-0727-1_3.

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Qi, Jianlong, Tom Michoel, and Gregory Butler. "Applying Linear Models to Learn Regulation Programs in a Transcription Regulatory Module Network." In Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-20389-3_4.

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Alinikula, Jukka, Olli Lassila, and Kalle-Pekka Nera. "DT40 mutants: a model to study transcriptional regulation of B cell development and function." In Subcellular Biochemistry. Springer Netherlands, 2006. http://dx.doi.org/10.1007/978-1-4020-4896-8_11.

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Cattini, Peter A., and Mary Lynn Duckworth. "Fo Transgenics for Studies of Transcriptional Control in vivo Tissue and Developmental—Specific Regulation of the Human and Rat Growth Hormone/Prolactin/Placental Lactogen Gene Family." In Transgenic Models in Endocrinology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1633-0_5.

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Tsong, Annie E., Brian B. Tuch, and Alexander D. Johnson. "Rewiring Transcriptional Circuitry: Mating-Type Regulation in Saccharomyces cerevisiae and Candida albicans as a Model for Evolution." In Sex in Fungi. ASM Press, 2014. http://dx.doi.org/10.1128/9781555815837.ch5.

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Conference papers on the topic "Transcription regulation model"

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Kononov, V. A. "Analysis of multiple transcription factors binding in the model plant genomes." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-014.

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Kononov, V. A. "Analysis of multiple transcription factors binding in the model plant genomes." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/bgrs/sb-2022-014.

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Mohbeddin, Abeer, Nawar Haj Ahmed, and Layla Kamareddine. "The use of Drosophila Melanogaster as a Model Organism to study the effect of Innate Immunity on Metabolism." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0224.

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Apart from its traditional role in disease control, recent body of evidence has implicated a role of the immune system in regulating metabolic homeostasis. Owing to the importance of this “immune-metabolic alignment” in dictating a state of health or disease, a proper mechanistic understanding of this alignment is crucial in opening up for promising therapeutic approaches against a broad range of chronic, metabolic, and inflammatory disorders like obesity, diabetes, and inflammatory bowel syndrome. In this project, we addressed the role of the Janus kinase/signal transducer and activator of tr
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Lambers, Christopher, Bernhard Burian, Bruno Robibaro, et al. "Distinct Regulation Of The Etareceptor Mrna Transcription And Proliferation Using An In Vitro Model Of Pulmonary Arterial Hypertension." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a3462.

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Дергилев, А. И., О. Б. Добровольская, Н. Г. Орлова, and Ю. Л. Орлов. "STUDY OF TRANSCRIPTIONAL REGULATORY CIRCUITS AND CLUSTERS OF TRANSCRIPTION FACTOR BINDING SITES IN PLANT GENOMES ACCORDING TO CHIP-SEQ DATA." In Биотехнология в растениеводстве, животноводстве и сельскохозяйственной микробиологии. Crossref, 2021. http://dx.doi.org/10.48397/arriab.2021.21.xxi.005.

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С развитием технологий высокопроизводительного геномного секвенирования, в том числе иммунопреципитации хроматина с последующим секвенированием ChIP-seq, появляется возможность исследовать сайты связывания транскрипционных факторов в масштабе генома для многих модельных организмов, включая растения, имеющие биотехнологическое значение. Объёмы данных об экспериментально определенных сайтах связывания продолжают расти, и это приводит к появлению всё новых и новых качественных задач биоинформатики, среди которых: определение параметров регуляции экспрессии генов транскрипционными факторами, опред
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Lillian, Todd D. "An Elastic Rod Representation for the LacI-DNA Loop Complex." In ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/detc2011-47407.

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The well-recognized Lac repressor protein (LacI) regulates transcription by bending DNA into a loop. In addition to the known role of DNA flexibility, there is accumulating evidence suggesting that the flexibility of LacI also plays a role in this gene regulation. Here we extend our elastic rod model for DNA (previously used to model DNA only) to represent LacI. Specifically, we represent sites of concentrated flexibility in the protein with flexible elastic rod domains; and we represent relatively rigid domains of the protein with stiff elastic rod domains. Our analysis shows the sensitivity
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"Reconstruction of mathematical frame models of bacterial transcription regulation based on transcriptional regulatory networks." In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-120.

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Ahmad, Salma, Hanan Nazar, Nouralhuda Alatieh, et al. "Validation of Novel Transcriptional Targets that Underpin CD44-promoted breast cancer cell invasion." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0153.

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Introduction: Breast cancer (BC) is the most common cancer worldwide, and metastasis is its worst aspect and the first cause of death. Metastasis is a multistep process, where an invasion is a recurring event. The process of BC cell invasion involves three major factors, including cell adhesion molecules (CAM), proteinases and Growth factors.CD44, a family of CAM proteins and the hyaluronic acid (HA) cell surface receptor, acts as cell differentiation, cell migration/invasion and apoptosis regulator. Rationale: We have previously established a tetracycline (Tet)-OFF-regulated expression system
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Giaretta, A. "A Minimal Stochastic Model of Transcriptional and Splicing Regulation." In 2020 42nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) in conjunction with the 43rd Annual Conference of the Canadian Medical and Biological Engineering Society. IEEE, 2020. http://dx.doi.org/10.1109/embc44109.2020.9176735.

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Cacace, Filippo, Lorenzo Farina, Alfredo Germani, and Pasquale Palumbo. "Discrete-time models for gene transcriptional regulation networks." In 2010 49th IEEE Conference on Decision and Control (CDC). IEEE, 2010. http://dx.doi.org/10.1109/cdc.2010.5717984.

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Reports on the topic "Transcription regulation model"

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Pichersky, Eran, Alexander Vainstein, and Natalia Dudareva. Scent biosynthesis in petunia flowers under normal and adverse environmental conditions. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7699859.bard.

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The ability of flowering plants to prosper throughout evolution, and for many crop plants to set fruit, is strongly dependent on their ability to attract pollinators. To that end many plants synthesize a spectrum of volatile compounds in their flowers. Scent is a highly dynamic trait that is strongly influenced by the environment. However, with high temperature conditions becoming more common, the molecular interplay between this type of stress and scent biosynthesis need to be investigated. Using petunia as a model system, our project had three objectives: (1) Determine the expression pattern
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Barg, Rivka, Erich Grotewold, and Yechiam Salts. Regulation of Tomato Fruit Development by Interacting MYB Proteins. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7592647.bard.

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Background to the topic: Early tomato fruit development is executed via extensive cell divisions followed by cell expansion concomitantly with endoreduplication. The signals involved in activating the different modes of growth during fruit development are still inadequately understood. Addressing this developmental process, we identified SlFSM1 as a gene expressed specifically during the cell-division dependent stages of fruit development. SlFSM1 is the founder of a class of small plant specific proteins containing a divergent SANT/MYB domain (Barg et al 2005). Before initiating this project,
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Ohad, Nir, and Robert Fischer. Regulation of Fertilization-Independent Endosperm Development by Polycomb Proteins. United States Department of Agriculture, 2004. http://dx.doi.org/10.32747/2004.7695869.bard.

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Arabidopsis mutants that we have isolated, encode for fertilization-independent endosperm (fie), fertilization-independent seed2 (fis2) and medea (mea) genes, act in the female gametophyte and allow endosperm to develop without fertilization when mutated. We cloned the FIE and MEA genes and showed that they encode WD and SET domain polycomb (Pc G) proteins, respectively. Homologous proteins of FIE and MEA in other organisms are known to regulate gene transcription by modulating chromatin structure. Based on our results, we proposed a model whereby both FIE and MEA interact to suppress transcri
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Eshed-Williams, Leor, and Daniel Zilberman. Genetic and cellular networks regulating cell fate at the shoot apical meristem. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7699862.bard.

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The shoot apical meristem establishes plant architecture by continuously producing new lateral organs such as leaves, axillary meristems and flowers throughout the plant life cycle. This unique capacity is achieved by a group of self-renewing pluripotent stem cells that give rise to founder cells, which can differentiate into multiple cell and tissue types in response to environmental and developmental cues. Cell fate specification at the shoot apical meristem is programmed primarily by transcription factors acting in a complex gene regulatory network. In this project we proposed to provide si
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Whitham, Steven A., Amit Gal-On, and Victor Gaba. Post-transcriptional Regulation of Host Genes Involved with Symptom Expression in Potyviral Infections. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593391.bard.

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Understanding how RNA viruses cause disease symptoms in their hosts is expected to provide information that can be exploited to enhance modern agriculture. The helper component-proteinase (HC-Pro) protein of potyviruses has been implicated in symptom development. Previously, we demonstrated that symptom expression is associated with binding of duplex small-interfering-RNA (duplex-siRNA) to a highly conserved FRNK amino acid motif in the HC-Pro of Zucchini yellow mosaic virus (ZYMV). This binding activity also alters host microRNA (miRNA) profiles. In Turnip mosaic virus (TuMV), which infects t
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Sionov, Edward, Nancy Keller, and Shiri Barad-Kotler. Mechanisms governing the global regulation of mycotoxin production and pathogenicity by Penicillium expansum in postharvest fruits. United States Department of Agriculture, 2017. http://dx.doi.org/10.32747/2017.7604292.bard.

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The original objectives of the study, as defined in the approved proposal, are: To characterize the relationship of CreA and LaeA in regulation of P T production To understand how PacC modulates P. expansumpathogenicity on apples To examine if other secondary metabolites are involved in virulence or P. expansumfitness To identify the signaling pathways leading to PAT synthesis Penicilliumexpansum, the causal agent of blue mould rot, is a critical health concern because of the production of the mycotoxinpatulin (PAT) in colonized apple fruit tissue. Although PAT is produced by many Penicilliums
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Meir, Shimon, Michael Reid, Cai-Zhong Jiang, Amnon Lers, and Sonia Philosoph-Hadas. Molecular Studies of Postharvest Leaf and Flower Abscission. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7696523.bard.

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Original objectives: Understanding the regulation of abscission competence by exploring the nature and function of auxin-related gene expression changes in the leaf and pedicelAZs of tomato (as a model system), was the main goal of the previously submitted proposal. We proposed to achieve this goal by using microarray GeneChip analysis, to identify potential target genes for functional analysis by virus-induced gene silencing (VIGS). To increase the potential of accomplishing the objectives of the previously submitted proposal, we were asked by BARD to show feasibility for the use of these two
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Yaron, Zvi, Abigail Elizur, Martin Schreibman, and Yonathan Zohar. Advancing Puberty in the Black Carp (Mylopharyngodon piceus) and the Striped Bass (Morone saxatilis). United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7695841.bard.

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Both the genes and cDNA sequences encoding the b-subunits of black carp LH and FSH were isolated, cloned and sequenced. Sequence analysis of the bcFSHb and LHb5'flanking regions revealed that the promoter region of both genes contains canonical TATA sequences, 30 bp and 17 bp upstream of the transcription start site of FSHb and LHb genes, respectively. In addition, they include several sequences of cis-acting motifs, required for inducible and tissue-specific transcriptional regulation: the gonadotropin-specific element (GSE), GnRH responsive element (GRE), half sites of estrogen and androgen
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Chen, Junping, Zach Adam, and Arie Admon. The Role of FtsH11 Protease in Chloroplast Biogenesis and Maintenance at Elevated Temperatures in Model and Crop Plants. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699845.bard.

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specific objectives of this proposal were to: 1) determine the location, topology, and oligomerization of FtsH11 protease; 2) identify the substrate/s of FtsH11 and the downstream components involved in maintaining thermostability of chloroplasts; 3) identify new elements involved in FtsH11 protease regulatory network related to HT adaptation processes in chloroplast; 4) Study the role of FtsH11 homologs from crop species in HT tolerance. Background to the topic: HT-tolerant varieties that maintain high photosynthetic efficiency at HT, and cope better with daily and seasonal temperature fluctu
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Lers, Amnon, and Pamela J. Green. LX Senescence-Induced Ribonuclease in Tomato: Function and Regulation. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7586455.bard.

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Natural leaf senescence, which occurs even when growth conditions are near optimal, has a negative influence on yield. Postharvest induced senescence contributes to the losses of quality in flowers, foliage, and vegetables. Strategies designed to control the senescence process in crop plants could therefore have great applied significance. However, the successful design of such strategies requires a better insight into the senescence machinery and control in higher plants. A main feature of senescence is the hydrolysis of macromolecules by hydrolases of various types such as ribonucleases (RNa
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