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Journal articles on the topic 'Trauma hemorrhagic shock'

Author: Grafiati

Published: 7 July 2024

Last updated: 31 July 2025

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1

Horton, J. W. "Cardiac contractile effects of ethanolism and hemorrhagic shock." American Journal of Physiology-Heart and Circulatory Physiology 262, no. 4 (1992): H1096—H1103. http://dx.doi.org/10.1152/ajpheart.1992.262.4.h1096.

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Moderate ethanol consumption, associated with cardiac depression, occurs in greater than 50% of trauma. Hemorrhagic shock, a significant component of trauma in the clinical setting, causes intrinsic cardiac contractile dysfunction. In this study, we used an isolated heart model to determine whether acute ethanolism increases the cardiovascular risk associated with hemorrhagic shock. We hypothesized that hemorrhagic shock in the acutely intoxicated subject would cause significantly greater cardiac dysfunction compared with that observed in a nonintoxicated subject. A total of 116 guinea pigs wa

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D'Alessandro, Angelo, Hunter B. Moore, Ernest E. Moore, et al. "Early hemorrhage triggers metabolic responses that build up during prolonged shock." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 308, no. 12 (2015): R1034—R1044. http://dx.doi.org/10.1152/ajpregu.00030.2015.

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Metabolic staging after trauma/hemorrhagic shock is a key driver of acidosis and directly relates to hypothermia and coagulopathy. Metabolic responses to trauma/hemorrhagic shock have been assayed through classic biochemical approaches or NMR, thereby lacking a comprehensive overview of the dynamic metabolic changes occurring after shock. Sprague-Dawley rats underwent progressive hemorrhage and shock. Baseline and postshock blood was collected, and late hyperfibrinolysis was assessed (LY30 >3%) in all of the tested rats. Extreme and intermediate time points were collected to assay the dynam

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GODINHO, MAURICIO, PEDRO PADIM, PAULO ROBERTO B. EVORA, and SANDRO SCARPELINI. "Curbing Inflammation in hemorrhagic trauma: a review." Revista do Colégio Brasileiro de Cirurgiões 42, no. 4 (2015): 273–78. http://dx.doi.org/10.1590/0100-69912015004013.

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Trauma is one of the world's leading causes of death within the first 40 years of life and thus a significant health problem. Trauma accounts for nearly a third of the lost years of productive life before 65 years of age and is associated with infection, hemorrhagic shock, reperfusion syndrome, and inflammation. The control of hemorrhage, coagulopathy, optimal use of blood products, balancing hypo and hyperperfusion, and hemostatic resuscitation improve survival in cases of trauma with massive hemorrhage. This review discusses inflammation in the context of trauma-associated hemorrhagic shock.

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Laserna, Anna Karen Carrasco, Yiyang Lai, Guihua Fang, et al. "Metabolic Profiling of a Porcine Combat Trauma-Injury Model Using NMR and Multi-Mode LC-MS Metabolomics—A Preliminary Study." Metabolites 10, no. 9 (2020): 373. http://dx.doi.org/10.3390/metabo10090373.

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Profiles of combat injuries worldwide have shown that penetrating trauma is one of the most common injuries sustained during battle. This is usually accompanied by severe bleeding or hemorrhage. If the soldier does not bleed to death, he may eventually succumb to complications arising from trauma hemorrhagic shock (THS). THS occurs when there is a deficiency of oxygen reaching the organs due to excessive blood loss. It can trigger massive metabolic derangements and an overwhelming inflammatory response, which can subsequently lead to the failure of organs and possibly death. A better understan

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Liu, Fu-Chao, Chih-Wen Zheng, and Huang-Ping Yu. "Maraviroc-Mediated Lung Protection following Trauma-Hemorrhagic Shock." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/5302069.

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Objectives.The peroxisome proliferator-activated receptor gamma (PPARγ) pathway exerts anti-inflammatory effects in response to injury. Maraviroc has been shown to have potent anti-inflammatory effects. The aim of this study was to investigate whether PPARγplays an important role in maraviroc-mediated lung protection following trauma-hemorrhage.Methods.Male Sprague-Dawley rats underwent trauma-hemorrhage (mean blood pressure maintained at approximately 35–40 mmHg for 90 minutes), followed by fluid resuscitation. During resuscitation, a single dose of maraviroc (3 mg/kg, intravenously) with and

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Napolitano, Lena M. "Resuscitation following trauma and hemorrhagic shock." Critical Care Medicine 23, no. 5 (1995): 795–97. http://dx.doi.org/10.1097/00003246-199505000-00001.

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Chu, Xiaogang, Kumar Subramani, Marie Warren, and Raghavan Pillai Raju. "Innate immune response in acute lung injury following hemorrhagic shock." Journal of Immunology 198, no. 1_Supplement (2017): 70.9. http://dx.doi.org/10.4049/jimmunol.198.supp.70.9.

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Abstract Trauma is the major cause of death for Americans under the age of 46 years. Hemorrhagic shock accounts for up to 40% of trauma-related deaths. Hemorrhagic shock evokes an acute, non-specific, systemic inflammatory response syndrome (SIRS) resulting in the damage to multiple organs. Acute lung injury (ALI) is one of the most serious complications in traumatic patients, however, the immunological mechanisms in ALI are still not well understood. Recently studies suggest that mitochondria play an important role in physical injury, leading to the onset of the SIRS. In order to address the

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Gauss, Tobias, Justin E. Richards, Costanza Tortù, et al. "Association of Early Norepinephrine Administration With 24-Hour Mortality Among Patients With Blunt Trauma and Hemorrhagic Shock." JAMA Network Open 5, no. 10 (2022): e2234258. http://dx.doi.org/10.1001/jamanetworkopen.2022.34258.

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ImportanceHemorrhagic shock is a common cause of preventable death after injury. Vasopressor administration for patients with blunt trauma and hemorrhagic shock is often discouraged.ObjectiveTo evaluate the association of early norepinephrine administration with 24-hour mortality among patients with blunt trauma and hemorrhagic shock.Design, Setting, and ParticipantsThis retrospective, multicenter, observational cohort study used data from 3 registries in the US and France on all consecutive patients with blunt trauma from January 1, 2013, to December 31, 2018. Patients were alive on admission

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Schneider, Christian P., Martin G. Schwacha, T. S. Anantha Samy, Kirby I. Bland та Irshad H. Chaudry. "Androgen-mediated modulation of macrophage function after trauma-hemorrhage: central role of 5α-dihydrotestosterone". Journal of Applied Physiology 95, № 1 (2003): 104–12. http://dx.doi.org/10.1152/japplphysiol.00182.2003.

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Androgens have been implicated as the causative factor for the postinjury immune dysfunction in males; however, it remains unknown whether androgens directly affect macrophages. To study this, male mice were sham operated or subjected to trauma (i.e., midline laparotomy) and hemorrhagic shock (mean arterial pressure, 30 ± 5 mmHg for 90 min and then resuscitated). The mice received the 5α-reductase inhibitor 4-hydroxyandrostenedione (4-OHA) before resuscitation. Plasma TNF-α, IL-6, and IL-10 levels were elevated after trauma-hemorrhage and normalized by 4-OHA. TNF-α and IL-6 production by splen

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Salvo, Nicholas, Angel M. Charles, and Alicia M. Mohr. "The Intersection of Trauma and Immunity: Immune Dysfunction Following Hemorrhage." Biomedicines 12, no. 12 (2024): 2889. https://doi.org/10.3390/biomedicines12122889.

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Hemorrhagic shock is caused by rapid loss of a significant blood volume, which leads to insufficient blood flow and oxygen delivery to organs and tissues, resulting in severe physiological derangements, organ failure, and death. Physiologic derangements after hemorrhage are due in a large part to the body’s strong inflammatory response, which leads to severe immune dysfunction, and secondary complications such as chronic immunosuppression, increased susceptibility to infection, coagulopathy, multiple organ failure, and unregulated inflammation. Immediate management of hemorrhagic shock include

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Fishman, Jordan E., Gal Levy, Vamsi Alli, Sharvil Sheth, Qu Lu, and Edwin A. Deitch. "Oxidative modification of the intestinal mucus layer is a critical but unrecognized component of trauma hemorrhagic shock-induced gut barrier failure." American Journal of Physiology-Gastrointestinal and Liver Physiology 304, no. 1 (2013): G57—G63. http://dx.doi.org/10.1152/ajpgi.00170.2012.

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Recent studies demonstrate that mechanisms underlying gut barrier failure include systemic processes and less studied luminal processes. We thus tested the hypothesis that mucus layer oxidation is a component of trauma/hemorrhagic shock-induced gut injury and dysfunction. Male Sprague-Dawley rats underwent trauma/hemorrhagic shock. Controls underwent trauma only. Mucus from the terminal 30 cm of the ileum was collected, processed, and analyzed for reactive nitrogen intermediates (RNI)-mediated damage, reactive oxygen species (ROS)-induced damage, and total antioxidant capacity. The distal ileu

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Rushing, G. D., R. C. Britt, J. N. Collins, F. J. Cole, L. J. Weireter, and L. D. Britt. "Adrenal Insufficiency in Hemorrhagic Shock." American Surgeon 72, no. 6 (2006): 552–54. http://dx.doi.org/10.1177/000313480607200619.

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Adrenal insufficiency during sepsis is well documented. The association between hemorrhagic shock and adrenal insufficiency is unclear and may be related to ischemia, necrosis, or resuscitation. This study was designed to determine the incidence of relative adrenal insufficiency in hemorrhagic shock. A retrospective review of a prospectively gathered database for patients admitted to the trauma intensive care unit with hemorrhagic shock was undertaken. A random serum cortisol of <25 mcg/dL defined relative adrenal insufficiency. All of the cortisol levels were drawn within the first 24 hour

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Larraga-García, Blanca, Aurora Pérez-Jiménez, Santiago Ros-Dopico, Javier Rubio-Bolívar, Manuel Quintana-Diaz, and Álvaro Gutiérrez. "Design and Development of a Hemorrhagic Trauma Simulator for Lower Limbs: A Pilot Study." Sensors 21, no. 11 (2021): 3816. http://dx.doi.org/10.3390/s21113816.

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One of the main preventable leading causes of death after a trauma injury is the hemorrhagic shock. Therefore, it is extremely important to learn how to control hemorrhages. In this paper, a hemorrhagic trauma simulator for lower limb has been developed and a pilot study has been accomplished to trail the simulator. Four different bleeding scenarios have been tested per participant, gathering information about the manual pressure exerted to control the bleeding. Data, altogether, from 54 hemorrhagic scenarios managed by final year medical students and doctors were gathered. Additionally, a pos

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Ba, Zheng F., Joachim F. Kuebler, Loring W. Rue, Kirby I. Bland, Ping Wang, and Irshad H. Chaudry. "Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function." American Journal of Physiology-Heart and Circulatory Physiology 284, no. 6 (2003): H2162—H2169. http://dx.doi.org/10.1152/ajpheart.00724.2002.

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Proestrous female rodents are protected from the deleterious effects of trauma-hemorrhage that are observed in males. We hypothesized that the gender dimorphic outcome after trauma-hemorrhage might be related to gender differences in endothelial function and organ perfusion under such conditions. Male and cycle-matched proestrous female Sprague-Dawley rats underwent a midline laparotomy, hemorrhagic shock (40 mmHg for ∼90 min), and resuscitation (Ringer lactate, 4× shed blood volume over 60 min). Various parameters were measured 2 h after completion of resuscitation. In the first set of animal

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15

Lee, Gil Jae. "The meaning and principles of damage control surgery." Journal of the Korean Medical Association 67, no. 12 (2024): 732–36. https://doi.org/10.5124/jkma.2024.67.12.732.

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Background: Trauma, especially hemorrhagic injury, remains a leading cause of morbidity and mortality worldwide. Prompt and effective management of these injuries is essential to improve patient outcomes.Current Concepts: Damage control surgery (DCS) has become a crucial approach for managing patients with severe traumatic hemorrhagic shock. DCS prioritizes physiological stabilization rather than definitive anatomical repair, initially focusing on controlling the hemorrhage and preventing further complications. This strategy is pertinent in patients with polytrauma, in which immediate surgical

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Hoen, Sophie, Karim Asehnoune, Sylvie Brailly-Tabard, et al. "Cortisol Response to Corticotropin Stimulation in Trauma Patients." Anesthesiology 97, no. 4 (2002): 807–13. http://dx.doi.org/10.1097/00000542-200210000-00010.

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Background An abnormal adrenocortical function and a vasopressor dependency have been demonstrated during septic shock. Because trauma and hemorrhage are the leading causes of noninfectious inflammatory syndromes, the goal of this study was to assess the adrenal reserve of trauma patients and its relation with clinical course. Methods Cortisol response to an intravenous corticotropin bolus was obtained in 34 young trauma patients (Injury Severity Score =29.1 +/- 7.3) at the end of the resuscitative period ("early phase") and at the end of the first posttraumatic week ("late period"). Cortisol

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Mileski, W. J., R. K. Winn, J. M. Harlan, and C. L. Rice. "Sensitivity to endotoxin in rabbits is increased after hemorrhagic shock." Journal of Applied Physiology 73, no. 3 (1992): 1146–49. http://dx.doi.org/10.1152/jappl.1992.73.3.1146.

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The immunoinflammatory response following trauma and hemorrhage may predispose to the development of sepsis and multiple-organ failure syndrome. Cardiac output (CO), arterial pressure, arterial PO2, and pulmonary permeability index were measured. We examined the sensitivity of rabbits to infusions of lipopolysaccharide (LPS) after hemorrhagic shock. Shock was produced by reducing CO to 40% of baseline for 90 min, followed by resuscitation with shed blood and then with lactated Ringer solution to maintain CO near baseline. Animals were assigned to three groups: 1) hemorrhagic shock only, 2) LPS

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Karavdić, K., A. Firdus, L. Kapetanović-Zametica, et al. "Hemorrhagic Shock Caused by Mesenteric Injury - Ski Pediatric Blunt Abdominal Trauma case report." Journal of Clinical Surgery and Research 3, no. 3 (2022): 01–08. http://dx.doi.org/10.31579/2768-2757/040.

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Trauma is the leading cause of pediatric mortality and abdominal injury is a significant contributor to morbidity. Abdominal trauma in the population of injured children, is the third leading cause of death in this population, after head and thoracic injuries. It is the most common cause of death owing to unrecognized injury. They most often occur in traffic accidents, games and sports. The clinical presentation depends on the severity of the injury, the injured organ and the associated injuries. Mesenteric injury from blunt abdominal trauma is uncommon and can be difficult to diagnose. It is

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Xu, Ying Xin, Alfred Ayala, and Irshad H. Chaudry. "Prolonged Immunodepression after Trauma and Hemorrhagic Shock." Journal of Trauma: Injury, Infection, and Critical Care 44, no. 2 (1998): 335–41. http://dx.doi.org/10.1097/00005373-199802000-00018.

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Heckbert, Susan R., Nicholas B. Vedder, Wilma Hoffman, et al. "Outcome after Hemorrhagic Shock in Trauma Patients." Journal of Trauma: Injury, Infection, and Critical Care 45, no. 3 (1998): 545–49. http://dx.doi.org/10.1097/00005373-199809000-00022.

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Alencar, Wellington Douglas Santos de, Jármison Luciano Pinheiro, Lara Beatriz Amorim Barbosa, et al. "ABORDAGEM INTEGRADA NO CHOQUE HIPOVOLÊMICO TRAUMÁTICO: RELATO DE CASO." Revista ft 29, no. 144 (2025): 45–46. https://doi.org/10.69849/revistaft/ni10202503231045.

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Hypovolemic shock is characterized by the acute loss of intravascular volume, compromising tissue perfusion and triggering a systemic inflammatory response. Among its subtypes, traumatic hemorrhagic shock stands out, in which acute hemorrhage and the release of inflammatory mediators contribute to the rapid progression of hemodynamic instability. A structured initial approach, such as that recommended by the Advanced Trauma Life Support (ATLS) protocol, is essential to minimize the morbidity and mortality associated with this condition. This study presents a clinical case report of a polytraum

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DEITCH, EDWIN A. "THE ROLE OF GENDER ON GUT BARRIER FUNCTION FOLLOWING TRAUMA-HEMORRHAGI TRAUMA-HEMORRHAGIC SHOCK." Shock 21, Supplement (2004): 74. http://dx.doi.org/10.1097/00024382-200403001-00293.

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Franco, Derek F., and Steven M. Zangan. "Interventional Radiology in Pelvic Trauma." Seminars in Interventional Radiology 37, no. 01 (2020): 044–54. http://dx.doi.org/10.1055/s-0039-3401839.

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AbstractTraumatic pelvic injuries are associated with high injury severity scores and significant morbidity and mortality. As fractures and ligamentous disruption result in increased pelvic volume, retroperitoneal hemorrhage can spiral and progress to hemorrhagic shock. Due to the extensive collateral supply and limitations of surgery for pelvic hematomas, angiographic treatment is at the forefront of pelvic trauma management. This article will discuss typical injuries seen in pelvic trauma, treatment modalities available to the interventional radiologist, and common angiographic treatment str

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Marjanović, Vesna, and Ivana Budić. "Fluid Resuscitation and Massive Transfusion Protocol in Pediatric Trauma." Acta Facultatis Medicae Naissensis 33, no. 2 (2016): 91–99. http://dx.doi.org/10.1515/afmnai-2016-0010.

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Summary Trauma is the leading cause of morbidity and mortality in children due to the occurrence of hemorrhagic shock. Hemorrhagic shock and its consequences, anemia and hypovolemia, decrease oxygen delivery, due to which appropriate transfusion and volume resuscitation are critical. Guidelines for massive transfusion, in the pediatric trauma, have not been defined yet. Current data indicate that early identification of coagulopathy and its treatment with RBSs, plasma and platelets in a 1:1:1 unit ratio, and limited use of crystalloids may improve survival in pediatric trauma patients.

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van Wessem, Karlijn J. P., and Luke P. H. Leenen. "Does Liberal Prehospital and In-Hospital Tranexamic Acid Influence Outcome in Severely Injured Patients? A Prospective Cohort Study." World Journal of Surgery 45, no. 8 (2021): 2398–407. http://dx.doi.org/10.1007/s00268-021-06143-y.

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Abstract Background Early hemorrhage control is important in trauma-related death prevention. Tranexamic acid (TXA) has shown to be beneficial in patients in hemorrhagic shock, although widespread adoption might result in incorrect TXA administration leading to increased morbidity and mortality. Methods A 7-year prospective cohort study with consecutive trauma patients admitted to a Level-1 Trauma Center ICU was performed to investigate administration of both pre- and in-hospital TXA and its relation to morbidity and mortality. Indication for prehospital and in-hospital TXA administration was

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Rajani, Ravi R., Chad G. Ball, David V. Feliciano, and Gary A. Vercruysse. "Vasopressin in Hemorrhagic Shock: Review Article." American Surgeon 75, no. 12 (2009): 1207–12. http://dx.doi.org/10.1177/000313480907501212.

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Trauma with resultant hypovolemic shock remains both prevalent and difficult to treat. Standard strategies using volume resuscitation and catecholamine support have historically yielded poor results. Vasopressin has emerged as a possible pharmacologic adjunct, particularly in patients with shock refractory to the administration of fluids and catecholamines. Much of the data regarding vasopressin is extrapolated from its usefulness in cases of nonhypovolemic human shock, which are supported by convincing animal studies. It is true that humans show a deficiency in vasopressin minutes after signi

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Angele, Martin K., Alfred Ayala, William G. Cioffi, Kirby I. Bland, and Irshad H. Chaudry. "Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage." American Journal of Physiology-Cell Physiology 274, no. 6 (1998): C1530—C1536. http://dx.doi.org/10.1152/ajpcell.1998.274.6.c1530.

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Studies indicate that, whereas immune functions in males are depressed, they are enhanced in females after trauma hemorrhage. Moreover, castration of male mice (i.e., androgen depletion) before trauma hemorrhage prevented the depression of cell-mediated immunity. Nonetheless, it remains unknown whether or not testosterone per se is responsible for producing the immune depression. To study this, female C3H/HeN mice ( n = 7 animals/group) were pretreated with 5α-dihydrotestosterone (DHT) or vehicle for 19 days, then subjected to laparotomy (e.g., trauma) and hemorrhagic shock (blood pressure 35

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Schmand, Jochen F., Alfred Ayala, Mary H. Morrison, and Irshad H. Chaudry. "Effects of hydroxyethyl starch after trauma-hemorrhagic shock." Critical Care Medicine 23, no. 5 (1995): 806–14. http://dx.doi.org/10.1097/00003246-199505000-00006.

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Gonzalez, E., E. E. Moore, M. V. Wohlauer, et al. "The Acute Endothelial Response to Trauma/Hemorrhagic Shock." Journal of Surgical Research 172, no. 2 (2012): 326–27. http://dx.doi.org/10.1016/j.jss.2011.11.593.

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Franchin, Marilyn, Daniel Jost, Hugues Lefort, Stephane Travers, and Jean-Pierre Tourtier. "Utility of shock index calculation in hemorrhagic trauma." American Journal of Emergency Medicine 33, no. 7 (2015): 978. http://dx.doi.org/10.1016/j.ajem.2015.04.001.

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Wohlauer, Max, Ernest E. Moore, Miguel Fragoso, et al. "Isoflurane suppresses inflammation following trauma and hemorrhagic shock." Journal of the American College of Surgeons 211, no. 3 (2010): S47. http://dx.doi.org/10.1016/j.jamcollsurg.2010.06.122.

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Caldwell, Nicole W., Mithun Suresh, Tricia Garcia-Choudary, and Christopher A. VanFosson. "CE: Trauma-Related Hemorrhagic Shock: A Clinical Review." AJN, American Journal of Nursing 120, no. 9 (2020): 36–43. http://dx.doi.org/10.1097/01.naj.0000697640.04470.21.

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Kumar, Manoj, and Sanjeev Bhoi. "Impaired hematopoietic progenitor cells in trauma hemorrhagic shock." Journal of Clinical Orthopaedics and Trauma 7, no. 4 (2016): 282–85. http://dx.doi.org/10.1016/j.jcot.2016.05.013.

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Kuebler, Joachim F., Balazs Toth, Yukihiro Yokoyama, Kirby I. Bland, Loring W. Rue, and Irshad H. Chaudry. "Alpha1-acid-glycoprotein protects against trauma-hemorrhagic shock." Journal of Surgical Research 119, no. 1 (2004): 21–28. http://dx.doi.org/10.1016/j.jss.2003.07.007.

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R. Doelle, Morrison, and Benjamin M. Predmore. "SARM1mediates TLR9-induced vascular hyperpermeability following hemorrhagic shock." American Journal of BioMedicine 6, no. 3 (2018): 264–79. http://dx.doi.org/10.18081/2333-5106/015-10/644-657.

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Hemorrhagic shock (HS) result in multiple organ dysfunction syndrome (MODS) and inflammatory response. It is one of the world's leading causes of death within the first 40 years of life and thus a significant health problem. The exact mechanism is not clear. TLRs are stimulated both by pathogen-associated molecular patterns as well as by damage-associated molecular patterns, including trauma and hemorrhagic shock. In the present study, we investigated whether the SARM1 responsible for mediats-TLR9-induces inflammatory process and vascular hyperpermeability following hemorrhagic shock. Here we

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Smith, Jennifer, Scott Bricker, and Brant Putnam. "Tissue Oxygen Saturation Predicts the Need for Early Blood Transfusion in Trauma Patients." American Surgeon 74, no. 10 (2008): 1006–11. http://dx.doi.org/10.1177/000313480807401027.

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Near-infrared spectroscopy (NIRS) has been used to measure regional tissue oxygen saturation (StO2) in skeletal muscle as an indicator of perfusion in trauma patients. In an effort to prospectively examine the usefulness of StO2 in identifying trauma patients in hemorrhagic shock, we evaluated the need for blood transfusion within 24 hours of injury as a marker of significant hemorrhage. A 6-month prospective, observational study was conducted at a university-affiliated, urban Level I trauma center using a convenience sample of 26 trauma patients thought to be at high risk for hemorrhagic shoc

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Raziya, Begum Sheikh, Akram Rabia, Ampeti Samatha, Shashikala BV Sonam, Srivastava Mansi, and Ravindra Sali Shubham. "Prompt Management of Major Injured Artery in a Young Adult Trauma Patient." medtigo Journal of Emergency Medicine 2, no. 2 (2025): e3092221. https://doi.org/10.63096/medtigo3092221.

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Hemorrhagic shock is a critical emergency condition affected by severe blood loss, leading to inadequate tissue perfusion and oxygen delivery. This report highlights the management of hemorrhagic shock in a 32-year-old female following an automobile accident with suspected femoral artery injury. Upon arrival in the emergency department, she presented with hypotension, tachycardia, and signs of significant blood loss. Immediate interventions included securing the airway, administering oxygen, and performing volume resuscitation with Ringer's lactate solution. A type and crossmatch for blood tra

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Sloan, Edward P., Max Koenigsberg, James M. Clark, and Amol Desai. "The Use of the Revised Trauma Score as an Entry Criterion in Traumatic Hemorrhagic Shock Studies: Data from the DCLHb Clinical Trials." Prehospital and Disaster Medicine 27, no. 4 (2012): 330–44. http://dx.doi.org/10.1017/s1049023x12000970.

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AbstractIntroductionThe Revised Trauma Score (RTS) has been proposed as an entry criterion to identify patients with mid-range survival probability for traumatic hemorrhagic shock studies.Hypothesis/ProblemDetermination of which of four RTS strata (1-3.99, 2-4.99, 1-4.99, and 2-5.99) identifies patients with predicted and actual mortality rates near 50% for use as an entry criterion in traumatic hemorrhagic shock clinical trials.MethodsExisting database analysis in which demographic and injury severity data from two prior international Diaspirin Cross-Linked Hemoglobin (DCLHb) clinical trials

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NOBRE, Karolyne Ernesto Luíz Lopes, Josean Victor Lopes Higino NOBRE, and JUNIOR Pedro Luiz do NASCIMENTO. "SHOCK INDEX AS A PREDICTOR OF SEVERITY IN HEMORRHAGIC SHOCK: A CRITICAL REVIEW." Boletim de Conjuntura (BOCA) 20, no. 60 (2024): 370–95. https://doi.org/10.5281/zenodo.14768748.

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This study aims to critically review the existing literature on the use of the Shock Index (SI) as a predictor of severity in hemorrhagic shock patients, assessing its effectiveness and limitations compared to other clinical indicators. An Integrative Literature Review was conducted, following Joanna Briggs Institute (JBI) guidelines. The research was performed in electronic databases, including PubMed, SciELO, and LILACS, using terms like "Shock Index" and "Hemorrhagic Shock." Studies published between 2019 and 2024 that analyzed the SI in trauma and surgery contexts were included. The qualit

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Angeli, Anastasia Pearl, Soni Sunarso Sulistiawan, Jimmy Yanuar Annas, and Pesta Parulian Maurid Edwar. "The Use of O Universal Profile Within Hemorrhagic Shock Post-partum Bleeding Patients in Dr. Soetomo General Hospital’s Emergency Installation." JAI (Jurnal Anestesiologi Indonesia) 14, no. 1 (2022): 13–18. http://dx.doi.org/10.14710/jai.v0i0.41691.

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Background: Hemorrhagic shock is one of the most common types of shock in trauma patients, and it is defined as acute blood volume loss. One of the causes of hemorrhagic shock is post-childbirth bleeding or post-partum bleeding. The most important management for patients who experience post-partum bleeding is blood transfusions. Type-O blood is known as a universal donor, because someone with type- O blood can transfuse theirs to recipients with blood types other than O. Giving blood transfusions to pos-tpartum bleeding patients is expected to extend their life expectancy, however it cannot be

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Carrick, Matthew M., Jan Leonard, Denetta S. Slone, Charles W. Mains, and David Bar-Or. "Hypotensive Resuscitation among Trauma Patients." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/8901938.

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Hemorrhagic shock is a principal cause of death among trauma patients within the first 24 hours after injury. Optimal fluid resuscitation strategies have been examined for nearly a century, more recently with several randomized controlled trials. Hypotensive resuscitation, also called permissive hypotension, is a resuscitation strategy that uses limited fluids and blood products during the early stages of treatment for hemorrhagic shock. A lower-than-normal blood pressure is maintained until operative control of the bleeding can occur. The randomized controlled trials examining restricted flui

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Simovic, Milomir O., James Bynum, Bin Liu, Jurandir J. Dalle Lucca, and Yansong Li. "Impact of Immunopathy and Coagulopathy on Multi-Organ Failure and Mortality in a Lethal Porcine Model of Controlled and Uncontrolled Hemorrhage." International Journal of Molecular Sciences 25, no. 5 (2024): 2500. http://dx.doi.org/10.3390/ijms25052500.

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Uncontrolled hemorrhage is a major preventable cause of death in patients with trauma. However, the majority of large animal models of hemorrhage have utilized controlled hemorrhage rather than uncontrolled hemorrhage to investigate the impact of immunopathy and coagulopathy on multi-organ failure (MOF) and mortality. This study evaluates these alterations in a severe porcine controlled and uncontrolled hemorrhagic shock (HS) model. Anesthetized female swine underwent controlled hemorrhage and uncontrolled hemorrhage by partial splenic resection followed with or without lactated Ringer solutio

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Feth, Maximilian, Felix Hezel, Michael Gröger та ін. "Metabolic Effects of Sodium Thiosulfate During Resuscitation from Trauma and Hemorrhage in Cigarette-Smoke-Exposed Cystathionine-γ-Lyase Knockout Mice". Biomedicines 12, № 11 (2024): 2581. http://dx.doi.org/10.3390/biomedicines12112581.

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Background: Acute and chronic pre-traumatic cigarette smoke exposure increases morbidity and mortality after trauma and hemorrhage. In mice with a genetic deletion of the H2S-producing enzyme cystathione-γ-lyase (CSE−/−), providing exogenous H2S using sodium thiosulfate (Na2S2O3) improved organ function after chest trauma and hemorrhagic shock. Therefore, we evaluated the effect of Na2S2O3 during resuscitation from blunt chest trauma and hemorrhagic shock on CSE−/− mice with pre-traumatic cigarette smoke (CS) exposure. Since H2S is well established as being able to modify energy metabolism, a

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Torres Filho, Ivo P., David Barraza, Kim Hildreth, Charnae Williams, and Michael A. Dubick. "Cremaster muscle perfusion, oxygenation, and heterogeneity revealed by a new automated acquisition system in a rodent model of prolonged hemorrhagic shock." Journal of Applied Physiology 127, no. 6 (2019): 1548–61. http://dx.doi.org/10.1152/japplphysiol.00570.2019.

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Local blood flow/oxygen partial pressure (Po2) distributions and flow-Po2 relationships are physiologically relevant. They affect the pathophysiology and treatment of conditions like hemorrhagic shock (HS), but direct noninvasive measures of flow, Po2, and their heterogeneity during prolonged HS are infrequently presented. To fill this void, we report the first quantitative evaluation of flow-Po2 relationships and heterogeneities in normovolemia and during several hours of HS using noninvasive, unbiased, automated acquisition. Anesthetized rats were subjected to tracheostomy, arterial/venous c

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Akhsan, Alfie Barkah, Nurhayat Usman, and Reno Rudiman. "The Relationship Between Initial Hematocrit and Base Excess For Signs Of Hemorrhagic Shock In Patients With Blunt Abdominal Trauma." Jurnal llmu Bedah Indonesia 45, no. 1 (2020): 3–15. http://dx.doi.org/10.46800/jibi-ikabi.v45i1.38.

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Introduction: Trauma abdominal and pelvic part of the largest causes of death and, if diagnosed early, the deaths could have been prevented. By increasing the capacity for early detection and prompt and appropriate action, will produce a satisfactory outcome. In patients with bleeding, hemodilution appear within a few minutes to obtain a decrease in hematocrit. BE decline is the result of pyruvic acid metabolism occurring anaerobic tissue hypoperfusion due to bleeding unresolved. There is a strong correlation between the decrease in hematocrit and BE with shock because of intra-abdominal haemo

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Tait, S. M., P. Wang, Z. F. Ba, and I. H. Chaudry. "Downregulation of hepatic beta-adrenergic receptors after trauma and hemorrhagic shock." American Journal of Physiology-Gastrointestinal and Liver Physiology 268, no. 5 (1995): G749—G753. http://dx.doi.org/10.1152/ajpgi.1995.268.5.g749.

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Although it is well known that sympathoadrenal activity increases under various adverse circulatory conditions, it is not known whether there are any alterations in hepatic plasma membrane beta-adrenergic receptors after trauma-hemorrhage and crystalloid resuscitation. To study this, rats underwent a 5-cm midline laparotomy (i.e., trauma induced) and were bled to and maintained at a mean arterial pressure of 40 mmHg until 40% of the maximal bleedout (MB) volume was returned in the form of Ringer lactate. The animals were then resuscitated with four times the volume of MB in the form of Ringer

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Do Amor Divino, Louise Amoedo, and Adolfo Savia. "Calcium Role In The Treatment Of Hemorrhagic Shock." South Health and Policy 4 (April 24, 2025): 208. https://doi.org/10.56294/shp2025208.

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Hemorrhagic Shock is a type of Hypovolemic Shock caused by large blood loss, making tissue perfusion difficult. Advanced Trauma Life Support (ATLS) emphasizes the need for a systematic and organized approach to the management of hemorrhagic shock, prioritizing rapid control of hemorrhage and restoration of adequate tissue perfusion through aggressive and timely resuscitation. Due to its effects on coagulation, cardiac function and nerve conduction, in recent years there has been a need to monitor and eventually administer calcium supplements to patients with Hemorrhagic Shock as part of a pack

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Rosenthal, Martin D., Ahsan Raza, Stephanie Markle, Chasen A. Croft, Alicia M. Mohr, and R. Stephen Smith. "The Novel Use of Resuscitative Endovascular Balloon Occlusion of the Aorta to Explore a Retroperitoneal Hematoma in a Hemodynamically Unstable Patient." American Surgeon 83, no. 4 (2017): 337–40. http://dx.doi.org/10.1177/000313481708300418.

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Balloon occlusion of the aorta was first described by C.W. Hughes in 1954, when it was used as a tamponade device for three wounded soldiers during the Korean War suffering from intra-abdominal hemorrhage. Currently, the device is indicated in trauma patients as a surrogate for resuscitative thoracotomy. Brenner et al. reported a case series describing the use of resuscitative endovascular balloon occlusion of the aorta (REBOA) in advanced hemorrhagic shock. Their conclusion was that “it is a feasible method for proximal aortic control.” We describe the novel use of REBOA before retroperitonea

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Nakazawa, Toshiki, Shokei Matsumoto, Natsuho Maekawa, Yudai Kumamoto, and Masayuki Shimizu. "Penetrating Liver Trauma Treated with a Multidisciplinary Approach in the Hybrid Emergency Room: All in One Room." Journal of Acute Care Surgery 14, no. 3 (2024): 130–33. http://dx.doi.org/10.17479/jacs.2024.14.3.130.

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Early diagnosis and management of liver trauma with hemorrhagic shock occasionally necessitates a multidisciplinary approach, involving emergency services, radiology, and the operating room, to control significant hemorrhage. In recent years, the use of all-in-one resuscitation rooms in Japan, known as hybrid emergency rooms (ER), has been expanding for trauma care. We present a case of a 50-year-old man with penetrating liver trauma that was rapidly treated in the hybrid ER from diagnosis to definitive care from surgery to angioembolization without transferring the patient (240 minutes). The

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O’Hollearn, Sean, Randall Schaefer, Cassandra DuBose, Darin Smith, and Carl Goforth. "Low-Titer O-Positive Whole Blood: Lessons From the Battlefield for Civilian Rural Hospitals." Critical Care Nurse 44, no. 5 (2024): 48–52. http://dx.doi.org/10.4037/ccn2024734.

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Low-titer O-positive whole blood was used extensively by the military during operations in Iraq and Afghanistan. Studies have consistently shown that this therapy is feasible, safe, and effective in the management of hemorrhagic shock in trauma patients, and it is now the standard of care across the US military Joint Trauma System. The military’s success in using low-titer O-positive whole blood has renewed the practice in the civilian setting, with recent research confirming its safety and efficacy. In a few short years, use of this treatment for hemorrhagic shock has expanded to more than 80

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