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1

1948-, Extein Irl, ed. Treatment of tricyclic-resistant depression. American Psychiatric Press, 1989.

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2

D, Amsterdam Jay, Hornig Mady 1957-, and Nierenberg Andrew A. 1955-, eds. Treatment-resistant mood disorders. Cambridge University Press, 2001.

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3

Kasper, S., and S. A. Montgomery. Treatment-resistant depression. Wiley-Blackwell, 2013.

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4

Kasper, Siegfried, and Stuart Montgomery. Treatment-resistant Depression. John Wiley & Sons, 2013. http://dx.doi.org/10.1002/9781118556719.

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5

Mädy, Hornig-Rohan, and Amsterdam Jay D, eds. Treatment-resistant depression. Saunders, 1996.

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6

Greden, John F. Treatment resistant depression: A roadmap for effective care. American Psychiatric Pub., 2011.

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7

Mathew, Sanjay J., and Carlos A. Zarate,, eds. Ketamine for Treatment-Resistant Depression. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-42925-0.

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8

McIntyre, Roger S., and André F. Carvalho. Treatment-resistant mood disorders. Oxford University Press, 2015.

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9

United States. Congress. Senate. Committee on Finance, ed. Committee staff report to the chairman and ranking member: Review of the FDA's approval process for the vagus nerve stimulation therapy system for treatment-resistant depression. U.S. G.P.O., 2006.

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10

Selek, Salih, Ives Cavalcante Passos, and Jair C. Soares. The management of treatment-resistant bipolar disorder. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0023.

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Treatment-resistant bipolar disorder is a challenging area in clinical psychiatry and both defining treatment resistance and managing it is difficult despite new emerging pharmacological and non-pharmacological treatments. This chapter revisits the definition in treatment resistance in bipolar and summarizes the general recommendations in treatment-resistant bipolar disorder by taking revision of the guidelines to ‘pole position’. Manic and depressive episodes are covered in different subtitles. A short description of the complementary and alternative treatments is also mentioned. Special cond
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11

Howland, Robert H. Multidisciplinary Treatments and Medications for Depressive Disorders and Comorbidity. Edited by C. Steven Richards and Michael W. O'Hara. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199797004.013.008.

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Compared with episodic depression, chronic depression and treatment resistant depression have higher rates of comorbidity, more persistent social and vocational disability, an increased risk of suicide, greater medical morbidity and mortality, and greater health care utilization and costs. A large number of antidepressant medications and other psychotropic drugs, depression-focused psychotherapies, and neuromodulation therapies are available for the treatment of depression. Many drugs or psychotherapies are used for the treatment of other psychiatric disorders or medical conditions, and they s
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12

Kasper, Siegfried, and Stuart A. Montgomery. Treatment-Resistant Depression. Wiley & Sons, Incorporated, John, 2013.

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13

Treatment-resistant depression. Saunders, 1996.

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14

Treatment-Resistant Depression. Elsevier, 2023.

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15

Kasper, Siegfried, and Stuart A. Montgomery. Treatment-Resistant Depression. Wiley & Sons, Incorporated, John, 2013.

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16

Cheng, Chih-Ming, and Cheng-Ta Li. Treatment-Resistant Depression. Elsevier, 2023.

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17

Kasper, Siegfried, and Stuart A. Montgomery. Treatment-Resistant Depression. Wiley & Sons, Incorporated, John, 2013.

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18

Kasper, Siegfried, and Stuart A. Montgomery. Treatment-Resistant Depression. Wiley & Sons, Limited, John, 2013.

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19

Posse, Patricio Riva, and William V. Bobo. Managing Treatment-Resistant Depression. Elsevier Science & Technology, 2022.

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20

Quevedo, Joao Luciano de, Patricio Riva Posse, and William V. Bobo. Managing Treatment-Resistant Depression. Elsevier Science & Technology Books, 2022.

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21

Amsterdam, Jay D., Andrew A. Nierenberg, and Mady Hornig. Treatment-Resistant Mood Disorders. Cambridge University Press, 2011.

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22

Amsterdam, Jay D., Andrew A. Nierenberg, and Mady Hornig. Treatment-Resistant Mood Disorders. Cambridge University Press, 2010.

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23

Pharmacotherapy for Depression and Treatment-Resistant Depression. World Scientific Publishing Co Pte Ltd, 2010.

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24

Pharmacotherapy for Depression and Treatment-Resistant Depression. World Scientific Publishing Co Pte Ltd, 2010.

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25

Ketamine for Treatment-Resistant Depression. Elsevier, 2021. http://dx.doi.org/10.1016/c2019-0-02581-2.

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26

Treatment-Resistant Depression Part B. Elsevier, 2023.

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27

Treatment-Resistant Depression Part B. Elsevier, 2023.

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28

Lam, Raymond W. Depression. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198804147.001.0001.

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Depression, Third Edition provides a succinct clinical guide for the recognition, diagnosis, management, and modalities of treatment of depressive disorders. This new edition includes the DSM-5 diagnostic criteria, updates the latest neurobiological and psychological findings, and summarizes the Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder. The initial chapters deal with the epidemiology, pathogenesis, clinical features, and diagnosis of depression. Basic principles of clinical management are prov
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29

Steinberg, Martin. Treatment of Depression. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199959549.003.0006.

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Most depression in the elderly can be effectively treated in the primary care setting. Psychiatric referral should be considered in the setting of severe depression, suicidal ideation, prior suicide attempts, multiple risk factors, psychotic symptoms, bipolar disorder, poor response to prior treatment, or high medical comorbidity. Combining pharmacological and psychosocial interventions is most likely to be effective. Available antidepressants include serotonin-specific reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, novel mechanism agents, tricyclic antidepressants, and mon
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30

Demitrack, Mark A., and Sarah H. Lisanby. Methodological issues in clinical trial design for TMS. Edited by Charles M. Epstein, Eric M. Wassermann, and Ulf Ziemann. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0039.

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This article explores the emergence of transcranial magnetic stimulation (TMS) as a new therapeutic approach and the implications of this technology for the study and treatment of neuropsychiatric disorders, with a focus on major depression. Relapse, chronicity, and varying degrees of treatment resistance characterize major depression. A substantial number of patients are not effectively treated with pharmacology or medications alone. It is proposed that TMS, along with other device-based therapies emerging in psychiatry, may define a potential new treatment platform, with existing therapeutic
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31

Vazquez, Gustavo H., Carlos A. Zarate, and Elisa Brietzke. Ketamine for Treatment-Resistant Depression: Neurobiology and Applications. Elsevier Science & Technology Books, 2020.

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32

Extein, Irl L. Treatment of Tricyclic Resistant Depression (Progress in Psychiatry). Cambridge University Press, 1990.

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33

Murrough, James. Therapies for Treatment-Resistant Depression: Neuropharmacology and Neurostimulation. Elsevier Science & Technology Books, 2024.

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34

Riba, Michelle B., John F. Greden, Melvin G. McInnis, and University of Michigan Comprehensive Depression Center. Treatment Resistant Depression: A Roadmap for Effective Care. American Psychiatric Association Publishing, 2011.

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35

Ketamine for Treatment-Resistant Depression: Neurobiology and Applications. Elsevier Science & Technology, 2020.

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36

Murrough, James. Therapies for Treatment-Resistant Depression: Neuropharmacology and Neurostimulation. Elsevier Science & Technology, 2024.

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37

Mathew, Sanjay J., and Carlos A. Zarate Jr. Ketamine for Treatment-Resistant Depression: The First Decade of Progress. Adis, 2016.

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38

Mathew, Sanjay J., and Carlos A. Zarate Jr. Ketamine for Treatment-Resistant Depression: The First Decade of Progress. Adis, 2018.

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39

Mathew, Sanjay J., Carlos A. Zarate, and Zarate Carlos A. Jr. Ketamine for Treatment-Resistant Depression: The First Decade of Progress. Adis International, Limited, 2016.

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40

Krystal, John H., and Dennis S. Charney. Current Treatments for Depression. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0031.

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Depression is among the most common and disabling medical disorders worldwide. Pharmacotherapy plays an important role in its treatment, although only half of all depressed patients show full remission with currently available therapies. This chapter reviews the most common pharmacotherapies with respect to their mechanisms of action, efficacy, tolerability, and safety. It also considers pharmacologic approaches to treatment-resistant symptoms of depression including adjunctive pharmacotherapies and the emerging rapid-acting antidepressants. An important focus of current research is to devise
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41

Lebovitz, Harold E., and Shlomo Ben-Haim. Novel technologies: What does gastric electrical stimulation offer to the patient with type 2 diabetes and depression? Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789284.003.0014.

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Owing to the epidemiologic dimensions of type 2 diabetes, obesity, and depression, the development of novel and effective treatment options for these conditions is of great importance. One of the major challenges in this field is that many antidiabetic and antidepressive drugs may have disadvantageous metabolic effects by increasing weight and worsening insulin resistance. Novel technologies more effectively considering the pathophysiological changes related to this entity are needed. The DIAMOND electrical stimulation device improves glycaemic control, causes weight loss and decreases systoli
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42

Diaz, Deborah. Treatment-Resistant Depression: Pharmacological Approaches, Challenges and Future Directions. Nova Science Publishers, Incorporated, 2017.

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43

Biernacki, Carolina, Prerna Martin, Pablo H. Goldberg, and Moira A. Rynn. Treatments for Pediatric Depression. Oxford University Press, 2015. http://dx.doi.org/10.1093/med:psych/9780199342211.003.0012.

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Practice guidelines recommend psychosocial interventions for mild or brief cases of pediatric depression. In moderate to severe cases, medication treatment is recommended, with or without cognitive-behavioral therapy (CBT). Fluoxetine and escitalopram are the only antidepressants approved by the U.S. Food & Drug Administration for acute pediatric depression. Among psychosocial interventions, CBT and interpersonal psychotherapy for adolescents (IPT-A) have the largest evidence base for treatment of depressed youth. Combination treatment with CBT and antidepressant medication is superior to
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44

Glick, Ronald, Marie Anne Gebara, and Eric Lenze. Integrative Geriatric Psychiatry. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190466268.003.0019.

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Psychiatric disorders, most prominently anxiety disorders and depression, are common among older adults and are associated with significant morbidity and impact on quality of life. Standard approaches, including pharmacotherapy and psychotherapy, are helpful for many patients, but treatment resistance and incomplete response are common. Complementary and integrative approaches have the potential to augment the response to traditional treatments. This chapter provides a background on the evaluation and management of these disorders. Treatment considerations focus on mind–body and biological app
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45

Tobon, Amalia Londono, and Hanna E. Stevens. Adolescents with SSRI-Resistant Depression. Edited by Ish P. Bhalla, Rajesh R. Tampi, Vinod H. Srihari, and Michael E. Hochman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190625085.003.0008.

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This chapter provides a summary of a landmark study in child and adolescent psychiatry addressing the common clinical experience of an adolescent that does not respond to initial antidepressant treatment. Should adolescents with selective serotonin reuptake inhibitor (SSRI) resistant depression be switched to another SSRI or to venlafaxine with or without cognitive behavioral therapy? Starting with that question, it describes the basics of the study, including funding, study locations, who was studied, how many patients, study design, study interventions, follow-up, endpoints, results, and cri
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46

O'Hara, Michael W., and C. Steven Richards. Epilogue. Edited by C. Steven Richards and Michael W. O'Hara. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199797004.013.037.

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The authors of the chapters in this volume have covered nearly every feature of depression comorbidity with other psychiatric disorders, chronic health conditions, and disturbed close relationships. Treatment implications are addressed both in chapters on individual disorders as well as comprehensively in separate chapters. This volume concludes with the “big picture” provided by Ronald Kessler and his colleagues. Several themes emerge. Depression comorbidity is pervasive. It touches to one degree or another almost every identifiable psychiatric condition, chronic health condition, and disturb
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47

Dutton, Garreth R., and Belinda L. Needham. Obesity. Edited by C. Steven Richards and Michael W. O'Hara. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199797004.013.021.

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Cross-sectional and longitudinal studies indicate a positive association between obesity and depression. While some evidence suggests that depression is a risk factor for obesity, other findings indicate that obesity is a risk factor for depression. Therefore the directionality of this relationship remains unclear. Alternatively, there may be common mediating biological or environmental contributors accounting for this association. Potential biological mediators include dysregulation of the HPA axis, leptin resistance, and inflammatory immune responses. Environmental and psychological mediator
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48

Treatment Resistant Depression, an Issue of Psychiatric Clinics of North America. Elsevier, 2023.

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49

Lam, Raymond W. Somatic treatments. Oxford University Press, 2012. http://dx.doi.org/10.1093/med/9780199692736.003.0008.

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• Wake therapy, exercise and light therapy are non-invasive and clinically useful treatments.• Electroconvulsive therapy remains an effective, safe and well-tolerated treatment for patients with severe, psychotic or medication-resistant depression.• Repetitive transcranial magnetic stimulation is an emerging treatment with evidence for acute efficacy, but with limited data about long-term management....
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50

Harrison, Katherine. Surviving Suicide: How One Woman Overcame Her Treatment Resistant Suicidal Depression and Anxiety Through Depression Hygiene. Independently Published, 2021.

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