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Dissertations / Theses on the topic 'Treatment resistance depression'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Draganov, Metodi. "Neurobiological factors associated with treatment response and resistance in Major Depression." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671083.

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La depressió és una malaltia heterogènia que afecta una part substancial de la població mundial en algun moment determinat de la seva vida. En els casos lleus, la gent pot sentir tristesa i apatia durant diversos dies per les coses que li agradava fer a la vida quotidiana, mentre que en els casos greus la persona pot necessitar una combinació d’antidepressius i psicoteràpia durant diversos anys. En aquests darrers casos, iniciar el tractament tard, per diversos factors com ara un diagnòstic poc clar, pot dificultar les possibilitats futures d’èxit. Fins el moment, el diagnòstic es basa en un e

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2

Garriock, Holly Ann. "Genetics of Major Depressive Disorder in Treatment Resistance and Tryptophan Depletion." Diss., Tucson, Arizona : University of Arizona, 2006. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1462%5F1%5Fm.pdf&type=application/pdf.

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3

de, la Salle Sara. "Electrophysiological Correlates and Predictors of the Antidepressant Response to Repeated Ketamine Infusions in Treatment-Resistant Depression." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41551.

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Traditional antidepressants, which act on the serotonin, dopamine, and norepinephrine systems, require many weeks to produce a therapeutic effect and are not effective for every patient. A sub-anesthetic dose of the anesthetic agent ketamine, a glutamate N-methyl-D-aspartate receptor antagonist, has been shown to produce a rapid and robust antidepressant effect in treatment-resistant major depressive disorder (MDD). As depressive symptoms typically return after one week following a single infusion, recent work has begun to focus on methods for prolonging the effects. Repeated infusions on a sp

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4

Kemp, David E. "Use of Insulin Sensitizers as a Novel Treatment for Major Depressive Disorder: A Pilot Study of Pioglitazone for Major Depression Accompanied by Abdominal Obesity." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1275567223.

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5

Rizzo, S. "Role of cytokines in treatment-resistant depression." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1387201/.

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The exact pathophysiology of major depressive disorder (MDD) has yet to be fully elucidated. The belief that depression is strictly a disorder of monoaminergic consequences is undergoing great reconsideration due to the lack of efficacy of the current pharmacotherapeutics. There is compelling clinical literature implicating a role for cytokines in the pathophysiology of MDD. IL-6 and IL-1β are pleiotropic inflammatory cytokines that have been reported to be elevated in patients with MDD. The present studies were undertaken to investigate the relationship between IL-6 and IL-1β in animal models

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6

Blom, Emma-Clara. "Ketamine for treatment-resistant depression : Moving away from conventional antidepressants." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20177.

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An increasing amount of research suggests Ketamine in subanaesthetic doses to be an effective antidepressant for Major Depressive Disorder (MDD) and Treatment-Resistant Disorder (TRD). After the finding that NMDA-receptor antagonists may hold antidepressant effect, several studies have suggested Ketamine to have great effect in relief of depressive symptoms. A time lag between biological and behavioural effects have been shown in currently available antidepressants and are not guaranteed to be efficient; only 30% of patients reach adequate response. The aim for this thesis is to systematically

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7

Wigmore, Eleanor May. "Regional brain volumes and antidepressant treatment resistance in major depressive disorder." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31291.

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Major depressive disorder (MDD) is a heritable and highly debilitating condition with antidepressants, first-line treatment, demonstrating low to modest response rates. No current biological mechanism substantially explains MDD but both neurostructural and neurochemical pathways have been suggested. Further explication of these may aid in identifying subgroups of MDD that are better defined by their aetiology. Specifically, genetic stratification provides an array of tools to do this, including the intermediate phenotype approach which was applied in this thesis. This thesis explores genetic o

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8

Cuomo, Alessandro. ""TREATMENT-RESISTANT DEPRESSION" AND USE OF INTRAVENOUS KETAMINE AND INTRANASAL ES-KETAMINE." Doctoral thesis, Università di Siena, 2021. http://hdl.handle.net/11365/1148507.

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Treatment-Resistant Depression (TRD) is defined as major depression characterized by the unsatisfactory response of two or more antidepressant therapies (adequate for dosage and duration), associated with a high incidence of comorbidities, with more marked impairment of functioning socio-occupational and greater risks of relapse, recurrence and suicidality. The high incidence of TRD has advanced scientific research towards the study of molecules with antidepressant action and with different mechanisms of action than those based on the monoaminergic theory. Ketamine is one of these molecules. A

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9

Abel, Anna Lucy. "Examining the process of change in cognitive behaviour therapy for treatment resistant depression." Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/15276.

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Objective: The present studies aimed to examine temporal patterns of symptom change over the course of cognitive behavioural therapy (CBT) in individuals with treatment-resistant depression (TRD) and evaluate their relationship to outcomes. They further sought to investigate whether case-conceptualisation competence, client hope and processing were associated with therapeutic change. Method: Participants were 156 individuals with TRD receiving 12-18 sessions of CBT as part of a randomised controlled trial. Depressive severity was assessed at each session. Audio-recordings of therapy sessions p

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10

Alkhateeb, Hebah, Gregory A. Ordway, W. Drew Gill, et al. "PARP1 inhibition produces unique antidepressant effects in an animal model of treatment-resistant depression." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/49.

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Major depressive disorder (MDD) is a prevalent and enervating mental illness affecting millions globally. Unfortunately, a significant proportion of patients do not receive clinical benefit from existing antidepressant medications. The limited effectiveness of currently available antidepressant drugs emphasizes the need to identify more effective medications for individuals who are treatment-resistant. We have previously reported abnormally elevated poly (ADP-ribose) polymerase-1 (PARP1) gene expression levels in the postmortem brain from MDD brain donors. PARP1 is a DNA damage repair enzyme t

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11

Ordway, Gregory A., W. D. Gill, J. B. Coleman, Hui Wang-Heaton, and Russell W. Brown. "Anti-Inflammatory PARP Inhibitor Demonstrates Antidepressant Activity in Animal Model of Treatment Resistant Depression." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/8643.

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Background: Major depressive disorder is associated with elevated levels of DNA oxidation, DNA damage, and gene expression of DNA repair enzymes including poly (ADP-ribose) polymerase-1 (PARP1). Elevated PARP1 activity is directly linked to neuroinflammation and PARP inhibitors are anti-inflammatory and neuroprotective. We previously showed that PARP inhibitors produce antidepressant-like effects equivalent to fluoxetine in rodent models. Here, we examined whether the PARP inhibitor 3-aminobenzamide (3AB) is effective in a rat model of treatment-resistant depression. Methods: Treatment-resis

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12

Angamia, Shareeka. "Longitudinal neuropsychological outcomes of deep brain stimulation for treatment resistant depression : a retrospective review." Diss., University of Pretoria, 2015. http://hdl.handle.net/2263/53414.

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The purpose of this study was to review the neuropsychological outcomes of bed nucleus of the stria terminalis (BNST) deep brain stimulation (DBS) for treatment resistant depression (TRD). In addition, this study would report the mood outcomes of the treatment. Previous research endeavours have explored the safety and efficacy of available treatment methods for TRD as well as the clinical outcomes. Studies have observed antidepressant effects in patients treated with DBS for TRD. However, limited research exists regarding neuropsychological outcomes. In this study a brief history of the patien

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13

Ferri, Giovanni. "Study on hippocampal brain volumes in treatment resistant depression during vagal nerve stimulation (VNS)." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421693.

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BACKGROUND: Volumetric changes in mood-relevant distributed limbic/paralimbic neurocircuitry have been reported in the recent literature on the course of Major Depression (MD). A decrease in hippocampal gray matter volumes is one of the possible mechanisms involved in pathogenesis of depression [Nifosì et al. 2010]. Converging evidences suggest that a reduced neurogenesis may occur in this area in recurrent depression and its positive modulation is fundamental for antidepressive action. Neurogenesis is stimulated both by plasticity-inducing stimuli (such as environmental enrichment, exercise,

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14

Hyde, Molly. "The Combined and Differential Effects of Monophasic and Biphasic Repetitive Transcranial Magnetic Stimulation on ERP-Indexed Attentional Processing in Treatment-Resistant Depression." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39932.

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In addition to low mood, major depressive disorder (MDD) is characterized by persistent cognitive deficits that impair daily functioning and resist improvement with conventional pharmacotherapies. Repetitive transcranial magnetic stimulation (rTMS) holds promise as an efficacious alternative, offering better outcomes than medication for patients with treatment-resistant depression (TRD). Yet, current rTMS protocols that administer sinusoidal biphasic pulses achieve remission in less than the majority. However, monophasic pulses may yield higher success rates based on greater cortical excitatio

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15

Symonds, Catherine. "The hypothalamic-pituitary-adrenal axis in depression : a focus on the hippocampus." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-hypothalamic--pituitary--adrenal-axis-in-depression-a-focus-on-the-hippocampus(65f9eca0-f831-4bf0-a934-0f3d21b8856c).html.

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Background: The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the aetiopathology of depression, and the incidence of HPA dysfunction tends to increase with the severity of treatment resistance. In healthy volunteers (HV), both acute and chronic hypercortisolaemia causes cognitive impairment, including emotional memory. The exact mechanism of this remains unclear; however the action of cortisol on corticosteroid receptors in the hippocampus appears to be crucial and this may also be important in the aetiopathology of depression. The aim of this thesis was to investigate acute

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16

Kalmus, Margot. "The prevalence of Comorbid conditions in a primary care sample of people with treatment resistant depression." Thesis, University of Essex, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517411.

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17

Kirby, Julia. "Neurobiological Bases of the Use of Atypical Antipsychotics in Treatment-Resistant Major Depressive Disorder." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/37242.

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Only one third of depressed patients experience a beneficial therapeutic effect after using a first-line medication, leaving two-thirds of patients without effective treatment. It has been shown that a combination of two drugs with different modes of action result in an increase in the number of patients responding to treatment. One of the most effective strategies is the addition of low doses of an atypical antipsychotic. In depth evaluation of the neurobiological properties of atypical antipsychotics have revealed that these agents produce antidepressant effects and enhance the therapeutic r

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18

Bauer, Michael, Mazda Adli, Tom Bschor, et al. "Lithium’s Emerging Role in the Treatment of Refractory Major Depressive Episodes: Augmentation of Antidepressants." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-134618.

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Background: The late onset of therapeutic response and a relatively large proportion of nonresponders to antidepressants remain major concerns in clinical practice. Therefore, there is a critical need for effective medication strategies that augment treatment with antidepressants. Methods: To review the available evidence on the use of lithium as an augmentation strategy to treat depressive episodes. Results: More than 30 open-label studies and 10 placebo-controlled double-blind trials have demonstrated substantial efficacy of lithium augmentation in the acute treatment of depressive episodes.

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19

Coleman, Joshua B., Wesley Drew Gill, Allee C. Maxwell, and Russell W. Brown. "Analysis of a Poly(ADP-ribose) Polymerase (PARP) Inhibitor in a Treatment-resistant Depression Model in the Rat." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/53.

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Over 16 million people in the US suffer from major depressive disorder (MDD) each year. Approximately 1/3rd of MDD patients (~5 million) obtain only partial remission or no benefit after trials with multiple drugs or drug combinations. Recently, Ordway and colleagues have reportedelevated levels of DNA oxidation and upregulated gene expression of the base excision repair enzyme poly(ADP-ribose) polymerase-1 (PARP1) in postmortem brain from donors who had MDD at the time of death, as compared to age-matched psychiatrically normal control donors. This study was designed to test whether an inhibi

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20

Arildsson, Mathilda. "Har ketamin effekt mot terapiresistent depression?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-81676.

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Depression är ett syndrom som drabbar mer än 300 miljoner människor i världen. Tillståndet förekommer i individuella variationer men vanliga symtom är nedstämdhet, energiförlust, störningar av sömn och aptit samt känslor av skuld och skam. En svår depression kan innebära lidande och stor funktionsförlust för den drabbade. Idag används både psykologisk och farmakologisk behandling, men det finns en problematik kring att det kan dröja veckor eller månader innan klinisk effekt ses av antidepressiva läkemedel. Därutöver blir en tredjedel av patienterna inte tillräckligt hjälpta av den behandling s

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21

Bauer, Michael, Mazda Adli, Tom Bschor, et al. "Lithium’s Emerging Role in the Treatment of Refractory Major Depressive Episodes: Augmentation of Antidepressants." Karger, 2010. https://tud.qucosa.de/id/qucosa%3A27581.

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Background: The late onset of therapeutic response and a relatively large proportion of nonresponders to antidepressants remain major concerns in clinical practice. Therefore, there is a critical need for effective medication strategies that augment treatment with antidepressants. Methods: To review the available evidence on the use of lithium as an augmentation strategy to treat depressive episodes. Results: More than 30 open-label studies and 10 placebo-controlled double-blind trials have demonstrated substantial efficacy of lithium augmentation in the acute treatment of depressive episodes.

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22

Phillips, Jennifer. "Effects of Remission and Genetic Variation on Brain Structure in Treatment-Resistant Major Depressive Disorder: A Prospective, Longitudinal Imaging Study." Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32102.

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Previous magnetic resonance imaging (MRI) studies have demonstrated brain atrophy in major depressive disorder (MDD) that is progressive with continuing illness and may be reversible with antidepressant treatment. What remains unclear is whether brain structure can be positively affected by pharmacological intervention even if patients fail to remit on the treatment. The primary aim of this thesis was to prospectively track changes in brain structure in patients with treatment-resistant depression while they underwent pharmacotherapy with the goal of attaining remission. There is evidence that

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23

Scott, Janine. "Chronic primary major depression : an exploratory analysis of factors associated with onset and outcome in patients with chronic treatment-resistant illness." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309034.

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24

Merolla, Aneliya B. "A study of the relationship between borderline-dysregulated personality and treatment-resistant depression in the course of the TADS randomised controlled trial." Thesis, University of Essex, 2017. http://repository.essex.ac.uk/19360/.

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Aim: This research project explored the relationship between borderline personality disorder, difficult to treat depression and treatment outcome. Method: The study used data collected in the course of the Tavistock Adult Depression Study (TADS). The TADS was a randomised controlled trial comparing Long Term Psychodynamic Psychotherapy (LTPP) to Treatment as Usual (TAU) for 129 patients whose depression has not been successfully treated by at least two previous interventions. The author of this project took part in rating all patients with the Shedler-Westen Assessment Profile (SWAP-II) – a 20

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25

Kiehl, Esther. "Evaluating the psychometric properties of the quality of life and enjoyment and satisfaction questionnaire in a primary care sample of individuals woth treatmet-resistant depression." Thesis, University of Essex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510505.

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26

Pert, Brian Daniel. "A systematic review of psychological therapies for treatment resistant depression and an investigation into the utility of family liaison meetings within an adult mental health rehabilitation and recovery setting." Thesis, Cardiff University, 2017. http://orca.cf.ac.uk/107855/.

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This thesis has been written in the format of three papers: a systematic review, an empirical paper and a critical reflection paper. Paper one presents a systematic review into the effectiveness of psychological treatments for treatment resistant depression in adults. Paper two presents a qualitative study aimed to explore utility of family liaison meetings in an adult mental health rehabilitation and recovery unit. Paper three presents a critical reflection on the process of conducting the research contained in this thesis and as such is not intended for publication. The implications of the r

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27

Mekiri, Maryam. "réponse, non-réponse et résistance aux traitements antidépresseurs monoaminergiques. Etude des marqueurs neurogéniques et moléculaires dans un modèle animal d'anxiété-dépression." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS051/document.

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Environ 30% des patients ne répondent pas de manière adéquate à un traitement antidépresseur. Cette absence de rémission, voire aggravation de l’état dépressif après la mise en place du traitement est qualifiée de non-réponse au traitement. La résistance au traitement est caractérisée lorsque cet échec thérapeutique est récurrent pour différentes stratégies thérapeutiques de mécanisme d’action différents. Afin d’améliorer les stratégies thérapeutiques visant à traiter les patients résistants, une meilleure compréhension des mécanismes biologiques associés à la non-réponse/résistance est nécess

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Delcourte, Sarah. "Potentialisation de la réponse antidépressive par la lumière : étude préclinique." Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1068/document.

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Le traitement de la dépression reste insatisfaisant. Avec un tiers des patients ne répondant à aucun traitement proposé, un délai d’action long, et des effets secondaires non négligeables, la nécessité de développer de nouvelles stratégies thérapeutiques devient urgente. La luminothérapie, traitement de choix de la dépression saisonnière, a été montrée depuis une trentaine d’années comme présentant également un intérêt pour le traitement des dépressions non saisonnières, unipolaires comme bipolaires. Cependant, les mécanismes d’actions sous-tendant l’effet antidépresseur de la lumière restent

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Devaux, Damien. "Le rôle de l'information visuelle dans la catégorisation émotionnelle au sein de deux psychopathologies." Thesis, Clermont-Ferrand 2, 2013. http://www.theses.fr/2013CLF20030.

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Un contenu visuel flou peut-il être efficace pour traiter de l’information émotionnelle ? Récemment, les travaux psychologiques en traitement émotionnel de l’information visuelle font état d’un lien particulier avec l’information de basses fréquences spatiales (BFS), grossière et floue mais rapide, qui permettrait la transmission très rapide de signaux au système émotionnel par rapport à une information de hautes fréquences spatiales (HFS) plus complexe et détaillée. En outre, l’information BFS serait primordiale dans la détection d’un danger potentiel de l’environnement et par conséquent enve

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Rothärmel, Maud. "La résistance pharmacologique dans les pathologies psychiatriques : Exemple de la dépression, la schizophrénie et l'autisme. Identification of potential genetic risk factors for bipolar disorder by whole-exome sequencing Les traitements pharmacologiques dans les troubles du spectre de l’autisme Troubles de l’humeur ? Quand recourir à la stimulation magnétique transcrânienne ? Repeated transcranial magnetic stimulation (rTMS) to improve electroconvulsive therapy (ECT) in TReatment-Resistant Depression : a report of two cases." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR125.

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Le problème de la pharmacorésistance est un phénomène courant en médecine et qui n’épargne pas la psychiatrie. Au même titre qu’on parle « d’épilepsie résistante », on parle de « dépression ou de schizophrénie résistante ». L’autisme est une situation un peu différente dans la mesure où il n’existe pas de traitement de référence pour les troubles du neurodéveloppement. Ces trois troubles, néanmoins, constituent des enjeux majeurs de santé publique tant du point de vue économique que sociétal, avec d’importantes répercussions fonctionnelles pour les patients. Après nous être interrogés dans une

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Richieri, Raphaëlle. "Substrats neuro-fonctionnels de la stimulation magnétique transcrânienne répétitive dans la dépression pharmaco-résistante." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5026.

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La pharmaco-résistance est une complication évolutive fréquente de l'épisode dépressif majeur. La rTMS est une technique de stimulation cérébrale innovante dont l'efficacité antidépressive est maintenant établie.Le premier objectif de notre travail de thèse a été de caractériser les substrats fonctionnels de la dépression pharmaco-résistante à l'aide de la technique TEMP, afin d'identifier des patterns d'anomalies cérébrales qui leur sont propres. Dans un second temps, et sur la base des travaux existant sur les mécanismes d'action de la rTMS, nous avons étudié la valeur prédictive de marqueur

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Blumberger, Daniel. "A Randomized Double Blind Sham-controlled Comparison of Bilateral and Unilateral Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Major Depression." Thesis, 2011. http://hdl.handle.net/1807/32917.

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Objectives: High frequency left-sided (HFL) and low frequency right-sided (LFR) unilateral repetitive transcranial magnetic stimulation (rTMS) are efficacious in treatment-resistant major depression (TRD). Similar benefit has been suggested for sequential bilateral rTMS (LFR then HFL). Therefore, this study evaluated the efficacy of HFL and sequential bilateral rTMS compared to sham in TRD. Methods: Seventy-four subjects between the ages of 18 and 85 with TRD and a 17-item Hamilton Depression Rating Scale (HDRS) greater than 21 were randomized to receive unilateral, bilateral, or sham rTMS

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Sousa, Ana Sofia Pereira de. "Neuro- and chronobiology of depression coupled to genetic polymorphisms of enzymes determine disease evolution and drug resistance?" Master's thesis, 2019. http://hdl.handle.net/10316/88399.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>A depressão é a principal causa de incapacidade, afetando mais de 300 milhões de pessoas em todo o mundo. Apesar do seu crescente impacto na saúde global, indivíduos com depressão apresentam, frequentemente, resistência aos tratamentos farmacológicos disponíveis, denominada de depressão resistente ao tratamento. Deste modo, uma das prioridades ao nível da saúde pública contempla a tentativa de aumentar os níveis de remissão. Neste contexto, o principal objetivo desta monografia consiste

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Nosrat, Sanaz. "Acute Effects of Resistance Exercise Intensity in a Depressed HIV Sample: The Exercise for People Who Are Immunocompromised (EPIC) Study." Thesis, 2018. https://doi.org/10.7916/D8VT38GS.

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Introduction: In the US, Black/African Americans comprise the largest proportion of People Living with HIV (PLWH). Depressive symptoms and fatigue are highly prevalent among PLWH. Depressive symptoms are linked to progression of HIV disease, and fatigue is linked to severity of depressive symptoms. Resistance exercise is known to have psychological benefits in non-HIV depressed populations, and these benefits are hypothesized to be intensity-dependent. That is, moderate intensity exercise seems to stimulate better psychological outcomes compared to other exercise intensities. To date, no study

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Sun, Yinming. "Deep Brain Stimulation Suppresses Gamma Oscillations in Treatment Resistant Depression." Thesis, 2012. http://hdl.handle.net/1807/35548.

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Background: Major depressive disorder is a debilitating psychiatric condition with high rates of treatment resistance that may be associated with working memory (WM) deficits. For treatment resistant depression (TRD) patients, deep brain stimulation (DBS) is emerging as an effective therapeutic option. Objective: To determine if electroencephalography signals recorded during DBS ON and OFF states while performing WM tasks can serve as biomarkers of therapeutic efficacy for DBS in TRD patients. Results: DBS stimulation suppressed frontal gamma oscillations (30–50Hz) during the ON state relative

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GUPTA, MAYA. "Understanding treatment-resistant depression: The complicated relationships among neurocognition, symptoms, and functioning." Thesis, 2011. http://hdl.handle.net/1974/6704.

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Background: Treatment-resistant depression (TRD) encompasses a segment of individuals with major depressive disorder who are severely ill in terms of chronicity, comorbidity, and prognosis. Although functional impairment is a prominent and costly feature of treatment-resistance, very little is known about the factors that contribute to and maintain functional impairment in TRD. Purpose: This study examined the relationships among neurocognition, symptoms, and functional impairment in TRD. Specifically, I examined the neurocognitive impairments that relate to different symptom domains and t

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Chang, Ting-Yu, and 張廷宇. "Neuromodulation by Theta-Burst Stimulation in Treatment-Resistant Major Depression: an MEG Study." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/91285379560253939351.

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碩士<br>國立陽明大學<br>生物醫學資訊研究所<br>103<br>Background: Theta-burst stimulation (TBS) appears to be a promising treatment alternative for depression. However, little is known about the underlying mechanism of its neuromodulation effect on emotion pathway for major depression. The aim of this study is to investigate the effect of neuromodulation on brain responses to emotional prosody in patients with treatment-resistant major depression by two-week TBS treatment using magnetoencephalography (MEG). Materials and Methods: Fourteen patients with treatment-resistant major depressive disorder (trMDD) and

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Teles, José Manuel Gomes Valinho Alves. "Psilocybin-assisted therapy as an option for treatment-resistant depression : a narrative review." Master's thesis, 2021. http://hdl.handle.net/10451/52520.

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Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2021<br>A Depressão Resistente ao Tratamento é um dos outcomes do Transtorno Depressivo Major e está associada uma baixa qualidade de vida e a um maior uso de cuidados de saúde. Evidência científica demonstrou que a psilocibina, um psicadélico clássico agonista do recetor 2A de serotonina, pode ser usado como uma opção terapêutica no tratamento de diversas doenças psiquiátricas. Este trabalho tem como propósito providenciar uma revisão integrativa da atual evidência científica sobre o uso

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Mota-Pereira, Jorge. "Exercise in the psychosocial rehabilitation of treatment-resistant major depressive disorder patients." Doctoral thesis, 2013. http://hdl.handle.net/1822/24866.

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Tese de doutoramento em Psicologia (área de especialização Psicologia do Desporto)<br>Major Depressive Disorder (MOD) is extremely incapacitating and difficult to manage, with high rates of non-remission with antidepressants, resulting in diverse functional impairment s. In order to achieve clinical remission multiple strategies are recommended, and exercise has been suggested as an effective augmentation therapy in addition to pharmacotherapy. However, studies performed to date have shown several methodological limitations, which hamper the implementation of these exercise programs. The m

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Chen, Mu-Hong, and 陳牧宏. "Low-dose ketamine infusion in treatment-resistant depression: a clinical, neurocognitive, inflammatory and neuroimaging study." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/x3z32x.

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博士<br>國立陽明大學<br>腦科學研究所<br>107<br>Increasing evidence supports a rapid antidepressant effect of a low-dose of ketamine infusion for Caucasian patients with treatment-resistant depression (TRD), a tremendous mental disorder resulting in the severe clinical and societal consequence, such as suicidality and loss of work function. Previous studies suggest the role of brain derived neurotrophic factor (BDNF) in the antidepressant effect of ketamine infusion. However, compared with Caucasian populations with higher prevalence of any Val allele of Val66Met BDNF polymorphism, Taiwanese people exhibit a

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Hsueh-IMou and 牟學懿. "Comparative Hospitalization and All-Cause Mortality Risk of Antipsychotic Augmentation in Aging Patients with Treatment-Resistant Depression." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/589k24.

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碩士<br>國立成功大學<br>臨床藥學與藥物科技研究所<br>106<br>Antipsychotic augmentation has been proven to pose favorable effects in patients with treatment-resistant depression (TRD). However, it raised a great concern of increased mortality risk in elderly patients receiving antipsychotics. The study aimed to compare the safety and effectiveness between antipsychotics. We analyzed the Taiwan National Health Insurance Research Database from 2001-2013 and identified patients with major depressive disorder aged 55 years and older, newly added on oral antipsychotics. We performed intention-to-treat analysis and follo

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GIRLANDA, Francesca. "LAST-RD STUDY – LITHIUM AND STANDARD THERAPY IN RESISTANT DEPRESSION. RANDOMIZED EVALUATION OF THE EFFECTIVENESS OF LITHIUM IN SUBJECTS WITH TREATMENT-RESISTANT DEPRESSION AND SUICIDE RISK. AN INDEPENDENT, PRAGMATIC, MULTICENTRE, PARALLEL-GROUP, SUPERIORITY TRIAL." Doctoral thesis, 2014. http://hdl.handle.net/11562/707569.

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Introduzione: Nella depressione resistente al trattamento (DRT), le idee autolesive e suicidarie rappresentano sintomi psicopatologici allarmanti. Questi possono portare a gesti autolesivi e tentativi di suicidio e, nel 10 % dei casi, a suicidi completi. Il trattamento conseguente al comportamento suicidario non-fatale è rilevante per la prevenzione del suicidio, perché il rischio di suicidio in seguito a gesti autolesivi è notevole. Obiettivo: L'obiettivo primario dello Studio LAST è valutare se il litio è efficace nel ridurre il rischio di suicidio in soggetti con DRT e rischio di suicidio.

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Slabbert, Francois Naude. "An analysis of antidepressant noncompliance in the private health sector of South Africa / Francois Naude Slabbert." Thesis, 2014. http://hdl.handle.net/10394/15553.

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The main aim of the thesis was to measure antidepressant (AD) non-compliance, to determine which factors are closely associated with AD non-compliance and the consequences of prolonged AD non-compliance in the private health sector of South Africa. The empirical study followed an observational, prospective, cohort study using longitudinal medicine claims data provided by a nationally representative Pharmaceutical Benefit Management company (PBM) from 1 January 2006 to 31 December 2011. Failure to respond to AD treatment and achieving remission has severe neurobiological and clinical consequenc

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Albrecht, Jakub. "Predikce terapeutické odpovědi při léčbě afektivních poruch repetitivní transkraniální magnetickou stimulací." Doctoral thesis, 2021. http://www.nusl.cz/ntk/nusl-448386.

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Prediction of the therapeutic response in the treatment of affective disorders using repetitive transcranial magnetic stimulation MUDr. Jakub Albrecht Summary Background: Transcranial magnetic stimulation (TMS) is an effective and safe neuromodulatory treatment of several neuropsychiatric conditions. Treatment resistant depression (TRD) is becoming the leading cause of morbidity and mortality. The design was narutallistic and observational. Methods: The cohort (2016-2018) contains 39 depressed patients (STAR*D grade ≥3). The parameters of TMS were: 10 days of 10 Hz stimulation with an energy o

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LaGarde, Elise. "La stimulation du nerf vague pour le traitement de la dépression réfractaire : les résultats après un an de suivi." Thèse, 2013. http://hdl.handle.net/1866/10591.

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La stimulation du nerf vague (SNV) a reçu l’approbation de Santé Canada en 2001, comme en Europe, pour le traitement de la dépression réfractaire et en 2005 aux États-Unis. Les études européennes et américaines rapportent un taux de réponse de 50% et de rémission de 30% après un an de traitement. La sélection des patients, encadrée par la recherche de marqueurs biologiques et des critères de résistance, pourrait contribuer à améliorer les taux de réponse. Cette étude décrit le suivi des patients ambulatoires souffrant de dépression réfractaire, d’un spectre unipolaire ou bipolaire (n=13) sous

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