Relevant bibliographies by topics / Trudeau Institute

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Academic literature on the topic 'Trudeau Institute'

Author: Grafiati
Published: 26 July 2024

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Journal articles on the topic "Trudeau Institute"

1

Wooley, Charles F. "Florence Rena Sabin (1871–1953), William Osler (1849–1919) and Tuberculosis." Journal of Medical Biography 13, no. 3 (August 2005): 162–69. http://dx.doi.org/10.1177/096777200501300311.

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Florence Rena Sabin received her MD from the Johns Hopkins University in 1900. She was one of the first women to become a medical intern at Johns Hopkins and worked for the year of her internship (1900–01) under William Osler. At Johns Hopkins from y>1902 to 1925, Sabin studied embryology and histology with mentor Franklin Mall. She became the first woman professor of histology at an American school. Recruited to the Rockefeller Institute (1925), she focused on tuberculosis immunology, tubercle-bacillus biochemistry and haematology. She was the first woman department head at the Rockefeller and, in 1925, the first woman elected to the National Academy of Sciences. Settling in Colorado in 1938, she entered public health, emphasizing tuberculosis control. She received the Trudeau Award in 1945 and the Lasker Award in 1951. Her experience with tuberculosis under Osler's tutelage defined the shape of her work in basic tuberculosis research and in public health.
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Tsukamoto, Hirotake, Karen Clise-Dwyer, Gail E. Huston, Amanda L. Buck, Debra K. Duso, Laura Haynes, and Susan L. Swain. "The Lifespan of Naïve CD4 T cells is a Critical Determinant for the Cellular Aging in Periphery (46.2)." Journal of Immunology 182, no. 1_Supplement (April 1, 2009): 46.2. http://dx.doi.org/10.4049/jimmunol.182.supp.46.2.

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Abstract Cell intrinsic functional defect in aged naive CD4 T cells is a key cause of an age-associated increase in susceptibility to infectious diseases. However the causes of the CD4 T cell defects and how they develop are largely unknown. We have suggested that many defects develop during the sojourn of the naïve CD4 T cells in the periphery. We report here that aged naïve CD4 T cells have a longer lifespan than young cells even when transferred to young intact hosts. In vitro studies suggest that their increased longevity is regulated by an intrinsic property for survival. Consistent with this, aged naïve CD4 T cells express reduced level of a pro-apoptotic molecule, Bim, and the reduction of Bim in naïve CD4 T cells is sufficient for longer lifespan in vivo. This longer lifespan of aged naïve T cells could contribute to the maintenance of T cell homeostasis in aged mice. On the other hand, shutdown of new T cell emigration from the thymus by thymectomy leads to long-term persistence of remaining naïve T cells in the periphery and accelerates development both of the functional defects and of increased lifespan in naive CD4 T cells. Neither of these is observed when new naïve T cells are derived from aged hematopoietic stem cells. Thus, these results suggest that development of functional defects in aged naive CD4 T cells is associated with long-term persistence of aged naïve T cells due to their increased lifespan in periphery. The authors have no financial conflict of interest. This work was supported by National Institutes of Health Grants AG025805, AG021600 and the Trudeau Institute.
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Hamada, Hiromasa, Maria de la Luz Garcia-Hernandez, Joyce B. Reome, Sara K. Misra, and Richard W. Dutton. "The mechanism of protection against influenza by transfer of Tc17, an IL-17 secreting CD8 T cell subset. (46.5)." Journal of Immunology 182, no. 1_Supplement (April 1, 2009): 46.5. http://dx.doi.org/10.4049/jimmunol.182.supp.46.5.

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Abstract Interleukin (IL) -17 secreting CD4 T (Th)17 and CD8 T (Tc)17 effector cells are found in the lung following primary challenge with influenza A and blocking antibody to IL-17 increases weight loss and reduces survival. Tc17 effectors can be generated in vitro using naïve CD8 T cells from OT-1 T cell receptor (TcR) transgenic mice. T cell numbers expand 20 fold and a majority secretes IL-17, but little IFN-γ. Tc17 effectors are negative for granzyme B, for perforin message and lack cytolytic activity in vitro, in contrast to Tc1 effectors. Many of the Tc17 effectors become IFN-γ/IL-17 double producers after adoptive transfer and kill targets by a Fas dependent, perforin independent, pathway in an in vivo CTL assay. Adoptively transferred Tc17 cells expand greatly after transfer to naïve recipients following challenge and can protect them against lethal influenza infection. Transfer of Tc17 effector cell enhances the infiltration of neutrophils and monocytes to lung after influenza infection and protects against the development of respiratory distress much more effectively than transfer of equivalent numbers of Tc1 effectors. Additional mechansims of protection are being explored. This work was supported by NIH AI046530 and the Trudeau Institute.
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Kohlmeier, Jacob E., Shannon C. Miller, Tres Cookenham, Alan D. Roberts, and David L. Woodland. "Type I interferon-dependent regulation of granzyme B protein expression by memory CD8+ T cells during the early stages of a respiratory virus challenge (130.13)." Journal of Immunology 182, no. 1_Supplement (April 1, 2009): 130.13. http://dx.doi.org/10.4049/jimmunol.182.supp.130.13.

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Abstract Memory T cells established following the resolution of influenza and parainfluenza virus infections provide robust protection from a secondary virus challenge. Recently, we demonstrated that the rapid recruitment of circulating memory CD8+ T cells to the lung airways during the early stages of a secondary challenge is crucial for limiting early viral replication. In the course of these studies, we observed that the cytolytic protein granzyme B (gzmB) was highly expressed by virus-specific memory CD8+ T cells recruited to the lung airways. However, the mechanism by which gzmB protein is up-regulated in these cells was unclear. In the current study, we demonstrate that challenge with a disparate virus is sufficient to up-regulate the expression of gzmB protein, suggesting that this process is antigen-independent. To discern the mechanism of gzmB protein expression, we employed a mixed bone marrow chimera model to directly compare wild-type and gene-deficient virus-specific memory CD8+ T cells within the same host. These studies demonstrate that the antigen-independent expression of gzmB protein was dependent on STAT1, and requires signaling through the IFNα/β receptor. Thus, type I interferons act directly on memory CD8+ T cells to increase gzmB protein expression during the early stages of a secondary virus challenge. This work is supported by funds from the NIH and the Trudeau Institute.
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Jelley-Gibbs, Dawn M., K. Kai McKinstry, John P. Dibble, Alan D. Roberts, David L. Woodland, and Susan L. Swain. "CD4 memory T cells regulate mediators of lung damage during respiratory infections (130.8)." Journal of Immunology 182, no. 1_Supplement (April 1, 2009): 130.8. http://dx.doi.org/10.4049/jimmunol.182.supp.130.8.

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Abstract Activated T cells play a central role in controlling respiratory virus infections. However, these T cells also mediate considerable pulmonary immunopathology and lung damage. The level of immunopathology tends to be much less in secondary compared to primary infections, but the underlying reasons for this difference are unclear. To determine if CD4 memory T cells regulate pulmonary immunopathology, we transferred influenza-specific CD4 memory T cells into naïve mice challenged with influenza virus and assessed (i) inflammation, (ii) antigen presentation, and (iii) de novo T cell stimulation in the lung environment. The presence of CD4 memory T cells during influenza infection greatly reduced the expression of pro-inflammatory cytokines and chemokines in the lungs, as well as the ability of alveolar macrophages and pulmonary dendritic cells to stimulate naïve CD4 and CD8 T cell responses directly ex vivo. CD4 memory T cells also inhibited the accumulation of newly primed CD4 and CD8 T cells in the lungs, without reducing virus titers or de novo T cell responses in the periphery. We propose that CD4 memory T cells are capable of limiting pulmonary immunopathology by preventing the influx and retention of newly primed T cells in the lungs during respiratory infections. We are currently assessing whether the effective induction of CD4 memory populations through vaccination protects against excessive pulmonary immunopathology and secondary bacterial pneumonia. Funded by NIH AI057158 NBC-Lipkin and Trudeau Institute.
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Brown, Deborah M., and Anna T. Lampe. "Combined CpG and MPL as vaccine adjuvants improve immunity and heterosubtypic protection against lethal viral challenge in single dose and prime/boost regimens." Journal of Immunology 208, no. 1_Supplement (May 1, 2022): 64.19. http://dx.doi.org/10.4049/jimmunol.208.supp.64.19.

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Abstract Current Influenza A virus (IAV) vaccines show poor efficacy, often 40–60%. A strategy to improve effectiveness of IAV vaccines is to include adjuvants to activate innate immunity. We examined the potential of combined pattern recognition receptor agonists CpG and MPL to increase IAV vaccine induced protection. When administered in a single, low dose intramuscular hemagglutinin (HA) protein vaccine, mice receiving MPL + CpG experienced less morbidity after homologous challenge compared to mice receiving single agonists. In experiments analyzing heterosubtypic protection, vaccines containing MPL delivered intramuscularly (i.m.) showed increased protection against weight loss while the addition of CpG enhanced antibody responses but not survival. To determine if MPL and CpG have combinatory effects at different sites, HA and NP were delivered with MPL i.m. while HA and NP were simultaneously delivered with CpG intranasally (i.n.). Data demonstrate that combination MPL i.m. + CpG i.n. abrogated morbidity, but did not improve survival compared to MPL + CpG i.m. Further, mice given MPL + CpG produced IgG antibodies that were cross-reactive to H1N1 virus, yet magnitude of antibody responses did not correlate with protective efficacy. Finally, comparison of MPL i.m. + CpG i.n. in a prime/boost regimen, followed by heterosubtypic challenge, showed that weight loss was significantly lowered in mice that received prime/boost vaccination compared to mice that received prime only. Higher antibody responses induced by a second dose of vaccine did not correlate with protective capacity, suggesting that antibody levels, while indicators of vaccine immunogenicity, do not directly correlate with ability to protect mice from severe disease. Supported by Trudeau Institute and Clarkson University.
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Brown, Deborah M., Jenna Briere, Hoi Lam Cheang, Dylan Custer, William C. Reiley, and Ethan Laferriere. "Combination adjuvants and antigens provide heterosubtypic protection against lethal influenza infection." Journal of Immunology 210, no. 1_Supplement (May 1, 2023): 223.20. http://dx.doi.org/10.4049/jimmunol.210.supp.223.20.

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Abstract Influenza A virus (IAV) is a negative strand RNA virus that undergoes antigenic drift and shift, leading to serologically distinct strains that can cause tens of thousands of deaths annually in the US. The wide variety of hemagglutinin (HA) and neuraminidase (NA) proteins necessitates yearly reformulation of the vaccine to protect against novel seasonal and pandemic strains. Current IAV vaccines do not contain adjuvants, however, immune modulators such as pattern recognition receptor (PRR) agonists may enhance antigen presentation to T cells and provide broader protection against IAV strains that differ in HA and NA outer coat proteins. We set out to investigate whether TLR4 (lipopolysaccharide) and TLR3 (poly IC) agonists in combination with HA (H3N2) and nucleoprotein (NP) or NP and matrix (M1) proteins could provide protection against lethal challenge with mismatched IAV strain H1N1. Mice given H3 and NP with LPS + pIC in a prime/boost strategy demonstrated 80% survival after heterosubtypic H1N1 challenge while H3 + NP in PBS showed 20% survival. Similar results were seen using LPS + pIC in combination with NP and M1 protein with 90% survival. High endpoint titers of anti-NP antibodies (that also bound H1N1 virus) correlated with heterosubtypic protection suggesting a role for non-neutralizing antibodies in promoting survival. In addition, LPS and pIC enhanced dendritic cell (DC) function in vitro and increased migratory monocyte DC in the lymph node in vivo, coupled with early upregulation of T cell marker CD69. This strategy may provide increased efficacy over current IAV vaccines by inducing non-neutralizing antibodies and enhanced T cell responses to internal proteins. Supported by Trudeau Institute and Clarkson University.
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8

Aragão, Gilbraz De Souza. "TENORIO MACIEL, Creômenes. «Pâque du Christ dans la Pâque du peuple, Pâque du peuple dans la Pâque du Christ: une lecture de l’oeuvre de l’inculturation liturgique de Jacques Trudel». Paris, 2017. Dissertação (Mestrado em Teologia) – Faculté de Théologie et de Sciences Religieuses, Institut Catholique de Paris, 2017." Revista de Teologia e Ciências da Religião da UNICAP 7, no. 2 (February 21, 2018): 317. http://dx.doi.org/10.25247/2237-907x.2017v7n2.p317-321.

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Com muito gosto lemos a dissertação de Creômenes Tenorio Maciel, intitulada «Pâque du Christ dans la Pâque du peuple, Pâque du peuple dans la Pâque du Christ: une lecture de l’oeuvre de l’inculturation liturgique de Jacques Trudel». Foi aprovada pelo Júri das Licenças Canônicas do Theologicum (Faculté de Théologie et de Sciences Religieuses - Institut Superieur de Liturgie) do Instituto Católico de Paris, neste ano de 2017, tendo como primeiro leitor J. L. Souletie e segundo leitor Philippe Barras. Creômenes é um jovem jesuíta brasileiro que prossegue seus estudos na França, mas busca desenvolver uma teologia cristã a partir da experiência religiosa do povo e tendo em vista a práxis, sobretudo litúrgica, das nossas comunidades de fé.
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9

Kabytov, Petr, Nadezhda Kabytova, and Ekaterina Barinova. "History of the Ufa nobility in the scientific works of M.I. Rodnov." OOO "Zhurnal "Voprosy Istorii" 2022, no. 3-2 (March 1, 2022): 121–30. http://dx.doi.org/10.31166/voprosyistorii202203statyi43.

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The article presents an analysis of the monographs of the leading researcher at the Institute of History, Language and Literature of the Ufa Federal Research Center of the Russian Academy of Sciences, doctor of sciences M. I. Rodnov, which he published in the 2010s. It has been proved that the reconstruction of the history of the Ufa nobility by the researcher was carried out as part of the longite period of 1861-1917, in which he identifies three stages. The scientific significance of published studies aimed at identifying the factors that caused the inefficiency of the economic activity of nobles in a market economy is shown. Discussion issues were outlined, it was proved that the noble elite, clinging by inertia to the past, was doomed to extinction.
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Wallace, Donald C. "Policy-Making and Canadian Intergovernmental RelationsECONOMIC RESURGENCE AND THE CONSTITUTIONAL AGENDA: THE CASE OF THE EAST COAST FISHERIES. A. Paul Pross and Susan McCorquodale. Kingston: Institute of Intergovernmental Relations, Queen’s University, 1987.TUG OF WAR: OTTAWA AND THE PROVINCES UNDER TRUDEAU AND MULRONEY. David A. Milne. Toronto: Lorimer, 1986.FEDERAL STATE, NATIONAL ECONOMY. Peter M. Leslie. Toronto: University of Toronto Press, 1987.CANADA: THE STATE OF THE FEDERATION 1986. Ed. Peter M. Leslie. Kingston: Institute of Intergovernmental Relations, Queens University, 1987." Journal of Canadian Studies 23, no. 3 (August 1988): 150–60. http://dx.doi.org/10.3138/jcs.23.3.150.

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Dissertations / Theses on the topic "Trudeau Institute"

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Valenzuela, Pilar M. "BARBARA TRUDELL. Más allá del aula bilingüe. Comunidades y Culturas Peruanas Nº 26. Ministerio de Educación-Instituto Lingüístico de Verano: Lima: ILV, 1995; 192 pp." Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/103113.

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Orellana, Basaletti Roxana Fiorangela. "Estudio comparativo de características morfofuncionales, sintomáticas y de autopercepción de fracturas de cóndilo mandibular, tratadas quirúrgica versus ortopédicamente, en Instituto Traumatológico y Hospital Barros Lucco Trudeau durante el período enero 2008-diciembre 2013, Santiago, Chile." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/131949.

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Trabajo de Investigación Requisito para optar al Título de Cirujano Dentista
Introducción: Las fracturas maxilofaciales generalmente se asocian con una gran morbilidad, pérdida de función, secuelas estéticas y altos costos financieros. La mandíbula es una de las estructuras óseas que con más frecuencia se fractura, donde las fracturas de cóndilo mandibular representan un 25-35% de todas las fracturas mandibulares. La falta de homogenización al clasificar las fracturas de cóndilo mandibular, protocolos poco claros y heterogeneidad en los métodos de medición han generado una multitud de artículos y revisiones en la literatura poco concluyentes y controversiales al momento de elegir entre un tratamiento quirúrgico u ortopédico para rehabilitar dichas fracturas. Chile no escapa a esto por lo cual es de vital importancia ahondar en la realidad clínica hospitalaria para determinar el mejor tratamiento para mejorar tanto sintomática y morfofuncional como la calidad de vida del paciente traumatizado. Material y Método: Se realizó un estudio transversal, observacional, analítico, de tipo cuantitativo en el Hospital Barros Luco Trudeau e Instituto Traumatológico del Dr. Teodoro Gebauer Weisser, consistente en la recolección de datos, citación, evaluación física, radiográfica y de autopercepción en pacientes con diagnóstico de fractura de cóndilo mandibular tratados quirúrgica y ortopédicamente entre enero del año 2008 y diciembre del año 2013. Los datos fueron tabulados, graficados y comparados estadísticamente según los objetivos planteados. Resultados: La muestra fue de 16 pacientes mayoritariamente de sexo masculino, promediaron 37 años de edad y todos pertenecían a FONASA. Pérdida de conocimiento, crisis epilépticas y asaltos fueron las principales etiologías descritas. Los pacientes tratados ortopédicamente sintieron más dolor durante el tratamiento, presentaron más cóndilos irregulares y acortamientos de rama mandibular en comparación a que aquellos quirúrgicamente tratados. Ambos grupos presentaron disfunción mandibular leve. En cuanto a la autopercepción de calidad de vida los ortopédicamente tratados la consideraban “buena” en contraste de los tratados quirúrgicamente quienes la describen como “excelente”. En conclusión, el tratamiento quirúrgico en este tipo de fracturas genera menor sintomatología, apropiadas características morfofuncionales y mejor autopercepción de calidad de vida que el tratamiento ortopédico. Se espera que este estudio sea parte de los cimientos en investigación de este tema en Chile.
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Books on the topic "Trudeau Institute"

1

M, Steinman Ralph, North Robert J. 1935-, and Trudeau Institute, eds. Mechanisms of host resistance to infectious agents, tumors, and allografts: A conference in recognition of the Trudeau Institute centennial. New York: Rockefeller University Press, 1986.

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Bocharov, V. I︠U︡. Sot︠s︡ialʹnyĭ institut naemnogo truda v sovremennoĭ Rossii. Samara: Izd-vo "Samarskiĭ universitet", 2010.

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F, Zubkova A., Beli͡a︡kov N. N, Moiseev A. I͡U︡, and Institut truda Ministerstva truda i sot͡s︡ialʹnogo razvitii͡a︡ RF., eds. Sot͡s︡ialʹnye lʹgoty i garantii: Po materialam "Kruglogo stola" Kluba "Realisty" i Instituta truda Ministerstva truda i sot͡s︡ialʹnogo razvitii͡a︡ RF. Moskva: Klub "Realisty", 1997.

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Bobolev, Vladimir Vasilʹevich. Geroĭ sot︠s︡ialisticheskogo truda SSSR, laureat Stalinskikh premiĭ Vasiliĭ Konstantinovich Bobolev: Sbornik vospominaniĭ i dokumentov ob osnovatele i pervom rukovoditele gazodinamicheskogo sektora No 3 KB-11 i ego uchastii v Atomnoĭ proekte SSSR : k istorii sozdanii︠a︡ Instituta ėksperimentalʹnoĭ gazodinamiki i fiziki vzryva RFI︠A︡T︠S︡-VNIIĖF. Sarov: FGUP "RFI︠A︡T︠S︡-VNIIĖF", 2015.

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Steinman, Ralph M. Mechanisms of Host Resistance to Infectious Agents, Tumors, and Allografts: A Conference in Recognition of the Trudeau Institute Centennial. Paul & Co Pub Consortium, 1986.

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Trudeau Vector. McArthur & Company, 2006.

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Jurjevics, Juris. Trudeau Vector: A Novel. Oldcastle Books, Limited, 2006.

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Jurjevics, Juris. Trudeau Vector: A Novel. Oldcastle Books, Limited, 2006.

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Trudeau Vector: A Novel. Allen & Unwin, 2006.

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Trudeau Vector: A Novel. Oldcastle Books, Limited, 2007.

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Book chapters on the topic "Trudeau Institute"

1

Hedberg Olenina, Ana. "Scores of Movement." In Psychomotor Aesthetics, 105–72. Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780190051259.003.0004.

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Chapter 3 examines the approaches to film actor training developed by the Soviet avant-garde filmmaker Lev Kuleshov in the early 1920s. Inspired by the radical innovations of contemporary theater, Kuleshov’s perspective on film acting relied on Ivan Pavlov’s and Vladimir Bekhterev’s reflexology, as well as psychotechnics and Taylorist labor efficiency training. Based on archival materials, this chapter establishes Kuleshov’s connection to the Central Institute of Labor (Tsentral’nyi Institut Truda) in Moscow, which promoted a utopian program of ingraining effective working skills in the nervous systems of factory workers by optimizing their trajectories of movement. Kuleshov embraced the concepts and techniques popularized by this Institute. He theorized his actors’ ideal performance in terms of energy expenditure and maximal use of the audiences’ attention span. My analysis of Kuleshov’s program for actors’ bodily discipline scrutinizes the training apparatuses he relied on in the hopes of achieving geometrically precise, rhythmical gestures, which he believed could form a legible “ornament” in rapid montage.
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Taber, Douglass F. "Organic Functional Group Interconversion." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0004.

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Gojko Lalic of the University of Washington developed (Angew. Chem. Int. Ed. 2014, 53, 6473) conditions for the preparation of the fluoride 2 by SN2 displacement of the triflate 1. Ross M. Denton of the University of Nottingham showed (Tetrahedron Lett. 2014, 55, 799) that a polymer-bound phosphine oxide activated with oxalyl bromide would convert an alcohol 3 to the bromide 4. The polymer could be filtered off and reactivated directly. Jonas C. Peters and Gregory C. Fu of Caltech devised (J. Am. Chem. Soc. 2014, 136, 2162) a photochemically-activated Cu catalyst that mediated the displacement of the bromide 5 by the amide 6 to give 7. Mark L. Trudell of the University of New Orleans used (Synthesis 2014, 46, 230) an Ir catalyst to couple the amide 9 with the alcohol 8, leading to 10. Tohru Fukuyama of Nagoya University converted (Org. Lett. 2014, 16, 727) the unsaturated aldehyde 11 into the ester 12. As the transformation proceeded via proton­ation of the enolized acyl cyanide, the less stable diastereomer was formed kinetically. Brindaban C. Ranu of the Indian Association for the Cultivation of Science developed (Org. Lett. 2014, 16, 1040) conditions for the coupling of an alkenyl halide 13 with a phenol, leading to the vinyl ether 14. Inter alia, this would be a convenient way to hydrolyze an alkenyl halide to the aldehyde. Vinyl ethers can also be oxidized directly to the ester, and to the unsaturated aldehyde. Pallavi Sharma and John E. Moses of the University of Lincoln observed (Org. Lett. 2014, 16, 2158) that the cyanation of the alkenyl halide 15 delivered 16, with retention of the geometry of the alkene. Jitendra K. Bera of the Indian Institute of Technology Kanpur uncovered (Tetrahedron Lett. 2014, 55, 1444) “on water” conditions for the hydrolysis of a terminal alkyne 17 to the methyl ketone 18. Jiannan Xiang and Weimin He of Hunan University prepared (Eur. J. Org. Chem. 2014, 2668) the keto phosphonate 20 by hydrolysis of the alkynyl phosphonate 19. Ken-ichi Fujita of the National Institute of Advanced Industrial Science and Technology cyclized (Tetrahedron Lett. 2014, 55, 3013) the alkyne 21 with CO₂, leading to 22.
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