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Journal articles on the topic 'Type-2 development'

Author: Grafiati

Published: 24 June 2021

Last updated: 29 July 2025

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1

Minal, C. Patel, and Singh S.K. "Obesity And Type 2 Diabetes Mellitus In Adolescents - A Review." International Journal of Basic and Applied Physiology 2, no. 1 (2013): 258–67. https://doi.org/10.5281/zenodo.4493768.

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: Obesity is highly prevalent in the modern world and it is associated with the development of a number of serious medical complications, like type 2 diabetes and cardiovascular diseases. Earlier, type 2 diabetes mellitus (T2DM) was regarded as a disease occurring in adults, while type 1 diabetes mellitus (T1DM) occurs in children and adolescents. This is true that T2DM is still more prevalent in adults, but there is increasing evidence that onset of type 2 diabetes in youth is frequently observed. Obesity increases the risk of T2DM by causing insulin resistance and directly or indirectly affe

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2

Jarvis, Blair, and Shelley Elkinson. "Agents in Development for Type 2 Diabetes." Drugs in R & D 2, no. 2 (1999): 95–99. http://dx.doi.org/10.2165/00126839-199902020-00002.

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3

Marott, Sarah C. W., Børge G. Nordestgaard, Anne Tybjærg-Hansen, and Marianne Benn. "Causal Associations in Type 2 Diabetes Development." Journal of Clinical Endocrinology & Metabolism 104, no. 4 (2018): 1313–24. http://dx.doi.org/10.1210/jc.2018-01648.

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Abstract Context Obesity, glucose, insulin resistance [homeostatic model assessment, version 2, for insulin resistance (HOMA2-IR)], and insulin secretion (HOMA2-β) have been associated with type 2 diabetes (T2D) observationally. However, the causal, genetic contribution of each parameter to this risk is largely unknown and important to study because observational data are prone to confounding but genetic, causal data are free of confounding and reverse causation. Objective We examined the causal, genetic contribution of body mass index (BMI), glucose level, C-peptide level, HOMA2-IR, and HOMA2

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4

Abdallah, Albajy Maitham, and Dan Florin Mihailescu. "Mechanisms of development of type 2 diabetes." International Journal of Biology Sciences 5, no. 1 (2023): 198–208. http://dx.doi.org/10.33545/26649926.2023.v5.i1c.187.

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5

Bhartia, Mithun, Abd A. Tahrani, and Anthony H. Barnett. "SGLT-2 Inhibitors in Development for Type 2 Diabetes Treatment." Review of Diabetic Studies 8, no. 3 (2011): 348–54. http://dx.doi.org/10.1900/rds.2011.8.348.

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6

Siva, Rami Reddy E., Parveen Kumar Sharma Dr., and Charanjeet Singh Dr. "Role of Homoeopathic Medicines in Type 2 Diabetes Mellitus." International Journal of Trend in Scientific Research and Development 3, no. 6 (2019): 127–33. https://doi.org/10.5281/zenodo.3587467.

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Diabetes Mellitus is metabolic disorder characterized by hyperglycemia in blood circulation mainly resulting from inadequate insulin secretion, insulin action or both and insulin resistance. Homoeopathic remedies have reported beneficial effect for treating in type 2 diabetes mellitus cases. Siva Rami Reddy E | Dr. Parveen Kumar Sharma | Dr. Charanjeet Singh "Role of Homoeopathic Medicines in Type 2 Diabetes Mellitus" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd

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7

Sayad, Maseera Fathima Arshad Shaik. "Incidence of Type 2 Respiratory Failure in Hypothyroidism." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 173–96. https://doi.org/10.5281/zenodo.14030809.

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The study investigates the incidence of Type 2 Respiratory Failure (T2RF) in hypothyroidism among 200 patients, exploring various parameters including age, gender, symptoms, exposure history, and comorbidities. T2RF, characterised by inadequate oxygenation of blood and retention of carbon dioxide, is a critical respiratory condition often associated with underlying medical disorders. Hypothyroidism, a common endocrine disorder resulting from decreased thyroid hormone production, can predispose individuals to respiratory complications, including T2RF, due to metabolic and respiratory muscle dys

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8

Lu, Da-Yong, Jin-Yu Che, Nagendra Sastry Yarla, et al. "Type 2 Diabetes Treatment and Drug Development Study." Open Diabetes Journal 8, no. 1 (2018): 22–33. http://dx.doi.org/10.2174/1876524601808010022.

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The causality and etio-pathologic risks for patients with Type 2 Diabetes (T2DM) are important areas in modern medicine. Disease complications are largely unpredictable in patients with T2DM. In the future, we welcome therapeutics of both cutting-edge and traditional for anti-diabetic treatments and management with higher efficiency and less cost. Expanding medical knowledge, behavior/life-style notification in healthcare, modern genetic/bioinformatics diagnostic promotion, clinical developments (Traditional Chinese Medicine and personalized medicine) and new drug developments - including cand

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9

MacKinnon, Neil J., Nicole R. Hartnell, Emily K. Black, et al. "Development of clinical indicators for type 2 diabetes." Canadian Pharmacists Journal 141, no. 2 (2008): 120–28. http://dx.doi.org/10.3821/1913-701x(2008)141[120:docift]2.0.co;2.

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10

Elizabeth, Miranda-Perez, Bentham Science Publisher Alarcon-Aguilar, Francisco J., Ortega-Camarillo Clara, Bentham Science Publisher Escobar-Villanueva та Maria Carmen. "Pancreatic β-Cells and Type 2 Diabetes Development". Current Diabetes Reviews 13, № 2 (2017): 108–21. http://dx.doi.org/10.2174/1573399812666151020101222.

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11

Li, Kejia, Xin Liao, Kuan Wang, et al. "Myonectin Predicts the Development of Type 2 Diabetes." Journal of Clinical Endocrinology & Metabolism 103, no. 1 (2017): 139–47. http://dx.doi.org/10.1210/jc.2017-01604.

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12

GOTOU, Naofumi, Shunsuke MIYAKE, and Toshiaki KANEMOTO. "506 Development of Yawing Type Hydroelectric Unit(2)." Proceedings of the Fluids engineering conference 2006 (2006): _506–1_—_506–4_. http://dx.doi.org/10.1299/jsmefed.2006._506-1_.

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13

ISHIHARA, Hiroaki, Naofumi GOTO, and Toshiaki KANEMOTO. "806 Development of Yawing Type Hydroelectric Unit(2)." Proceedings of the Fluids engineering conference 2007 (2007): _806–1_—_806–4_. http://dx.doi.org/10.1299/jsmefed.2007._806-1_.

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14

Leiherer, Andreas, Axel Muendlein, Thomas Plattner, et al. "Ceramides predict the development of type 2 diabetes." Atherosclerosis 395 (August 2024): 118016. http://dx.doi.org/10.1016/j.atherosclerosis.2024.118016.

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15

Brooks-Worrell, Barbara, Heba Ismail, Michael Wotring, et al. "Autoimmune Development in Phenotypic Type 2 Diabetes Patients." Clinical Immunology 123 (2007): S66—S67. http://dx.doi.org/10.1016/j.clim.2007.03.367.

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16

Meier, Juris J., and Michael A. Nauck. "Incretins and the development of type 2 diabetes." Current Diabetes Reports 6, no. 3 (2006): 194–201. http://dx.doi.org/10.1007/s11892-006-0034-7.

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17

Fernandes, P., C. Peixoto, V. M. Santiago, E. J. Kremer, A. S. Coroadinha, and P. M. Alves. "Bioprocess development for canine adenovirus type 2 vectors." Gene Therapy 20, no. 4 (2012): 353–60. http://dx.doi.org/10.1038/gt.2012.52.

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18

Leiherer, Andreas, Axel Muendlein, Thomas Plattner, et al. "CERAMIDES PREDICT THE DEVELOPMENT OF TYPE 2 DIABETES." Journal of the American College of Cardiology 83, no. 13 (2024): 2026. http://dx.doi.org/10.1016/s0735-1097(24)04016-6.

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19

SULLIVAN, MICHELE G. "Type 2 Diabetes Linked to Development of Parkinson's." Clinical Endocrinology News 2, no. 5 (2007): 5. https://doi.org/10.1016/s1558-0164(07)70278-x.

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20

Aknazarova, Komila Azamat kizi, Marjona Khairulla kizi Saifullaeva, Durdona Murod kizi Bakhrillaeva, and Avaz Eshmamatovich Kodirov. "Type 2 diabetes mellitus." Research and implementation 2, no. 10 (2024): 49–53. https://doi.org/10.5281/zenodo.14011118.

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The article discusses the features of type 2 diabetes mellitus, its causes, risk factors and clinical manifestations. An analysis of the literature on the prevalence of the disease, factors influencing its development, and methods of prevention and treatment is provided. Particular attention is paid to the role of lifestyle and diet in reducing the risk of complications.

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21

Khalid Iqbal, Rana. "Type 2 Diabetes and its Treatment." Diabetes & Obesity International Journal 4, no. 3 (2019): 1–3. http://dx.doi.org/10.23880/doij-16000208.

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Type 2 diabetes is chronic disease that is spreading all over the world. In type 2 diabetes mainly there is less insulin production. It can be diet-induced and may also be associated with obesity. The body weight of a person increases due to more energy taken by the food, also the physical activity with less workout may lead to abdominal adiposity and finally the insulin resistance. Insulin resistance leads to the development of type 2 diabetes. The ratio of diabetic patients is increasing day by day. 90% of the total diabetic patients have type 2 diabetes. The risk of developing type 2diabete

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22

Timchenko, Lubov. "Development of Therapeutic Approaches for Myotonic Dystrophies Type 1 and Type 2." International Journal of Molecular Sciences 23, no. 18 (2022): 10491. http://dx.doi.org/10.3390/ijms231810491.

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Myotonic Dystrophies type 1 (DM1) and type 2 (DM2) are complex multisystem diseases without disease-based therapies. These disorders are caused by the expansions of unstable CTG (DM1) and CCTG (DM2) repeats outside of the coding regions of the disease genes: DMPK in DM1 and CNBP in DM2. Multiple clinical and molecular studies provided a consensus for DM1 pathogenesis, showing that the molecular pathophysiology of DM1 is associated with the toxicity of RNA CUG repeats, which cause multiple disturbances in RNA metabolism in patients’ cells. As a result, splicing, translation, RNA stability and t

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23

Sodikovna, Abdurazakova Dilbar, Yusupova Shahnoza Kadirjanovna, SaidjonovaFeruza Latifjonovna, and Jabbarov Ibrohimjon Adhamjon O’gli. "PREVENTION OF TYPE 2 DIABETES MELLITUS." American Journal Of Biomedical Science & Pharmaceutical Innovation 4, no. 3 (2024): 44–51. http://dx.doi.org/10.37547/ajbspi/volume04issue03-06.

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Prevention of type 2 diabetes mellitus and complications is an urgent problem in modern medicine. In patients with a body mass index (BMI) above 25 kg/m2, indicators of markers of carbohydrate metabolism (serum glucose -fasting and postprandial glycemia, glycosylated hemoglobin and urine glucose) and lipid metabolism -total cholesterol (TC), triglycerides (TG), lipidogram (low-density lipoprotein cholesterol -LDL cholesterol, atherogenic index -AI is significantly higher, and high-density lipoprotein cholesterol -HDL cholesterol is significantly lower than in patients with normal body mass ind

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24

Antonijevic, Zoran, Martin Kimber, David Manner, Carl-Fredrik Burman, José Pinheiro, and Klas Bergenheim. "Optimizing Drug Development Programs: Type 2 Diabetes Case Study." Therapeutic Innovation & Regulatory Science 47, no. 3 (2013): 363–74. http://dx.doi.org/10.1177/2168479013480501.

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25

Marshall, J. A., and D. H. Bessesen. "Dietary Fat and the Development of Type 2 Diabetes." Diabetes Care 25, no. 3 (2002): 620–22. http://dx.doi.org/10.2337/diacare.25.3.620.

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26

Tachibana, Kimiyasu. "Development of Tubular Type SOFC by Wet Process (2)." ECS Proceedings Volumes 1995-1, no. 1 (1995): 208–15. http://dx.doi.org/10.1149/199501.0208pv.

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27

Verma, Subodh, Abhinav Sharma, Naresh Kanumilli, and Javed Butler. "Predictors of heart failure development in type 2 diabetes." Current Opinion in Cardiology 34, no. 5 (2019): 578–83. http://dx.doi.org/10.1097/hco.0000000000000647.

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28

Reagan, L. P., M. Theveniau, X. D. Yang, et al. "Development of polyclonal antibodies against angiotensin type 2 receptors." Proceedings of the National Academy of Sciences 90, no. 17 (1993): 7956–60. http://dx.doi.org/10.1073/pnas.90.17.7956.

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29

Hoshino, Kazumi, Steven H. Zarit, and Makoto Nakayama. "Development of the Gerotranscendence Scale Type 2: Japanese Version." International Journal of Aging and Human Development 75, no. 3 (2012): 217–37. http://dx.doi.org/10.2190/ag.75.3.b.

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30

Quinn, Laurie. "Mechanisms in the Development of Type 2 Diabetes Mellitus." Journal of Cardiovascular Nursing 16, no. 2 (2002): 1–16. http://dx.doi.org/10.1097/00005082-200201000-00002.

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31

Xie, Xi-tao, Qiang Liu, Jie Wu, and Makoto Wakui. "Impact of cigarette smoking in type 2 diabetes development." Acta Pharmacologica Sinica 30, no. 6 (2009): 784–87. http://dx.doi.org/10.1038/aps.2009.49.

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32

Pinney, Sara E., and Rebecca A. Simmons. "Epigenetic mechanisms in the development of type 2 diabetes." Trends in Endocrinology & Metabolism 21, no. 4 (2010): 223–29. http://dx.doi.org/10.1016/j.tem.2009.10.002.

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33

Weiss, Ram, Sara E. Taksali, and Sonia Caprio. "Development of type 2 diabetes in children and adolescents." Current Diabetes Reports 6, no. 3 (2006): 182–87. http://dx.doi.org/10.1007/s11892-006-0032-9.

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34

Hampton, Tracy. "Cilia Dysfunction May Promote Development of Type 2 Diabetes." JAMA 313, no. 1 (2015): 20. http://dx.doi.org/10.1001/jama.2014.17620.

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35

Loering, Svenja, Guy J. M. Cameron, Malcolm R. Starkey, and Philip M. Hansbro. "Lung development and emerging roles for type 2 immunity." Journal of Pathology 247, no. 5 (2019): 686–96. http://dx.doi.org/10.1002/path.5211.

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36

Hardman, Timothy Colin, and Simon William Dubrey. "Development and potential role of type-2 sodium-glucose transporter inhibitors for management of type 2 diabetes." Diabetes Therapy 2, no. 3 (2011): 133–45. http://dx.doi.org/10.1007/s13300-011-0004-1.

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37

Asfandiyarova, N. S. "TYPE 2 DIABETES MELLITUS – AN AUTOIMMUNE DISEASE?" Russian Journal of Immunology 23, no. 1 (2020): 9–18. http://dx.doi.org/10.46235/1028-7221-001-tdm.

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In recent years, the association of type 2 diabetes mellitus (DM) to autoimmune diseases has been discussed. Participation of innate immunity in the development of inflammation in obesity and insulin resistance, which determine the development of type 2 DM is well known. These changes, along with gluco- and lipotoxicity, lead to the destruction of the pancreatic β cells, emergence of autoantigens and development both humoral and cell type autoimmune reactions. The effectiveness of drugs used in the treatment of autoimmune diseases also leads some authors to the conclusion that type 2 diabetes

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38

Browne, Jessica L., Adriana D. Ventura, Kylie Mosely, and Jane Speight. "Measuring the Stigma Surrounding Type 2 Diabetes: Development and Validation of the Type 2 Diabetes Stigma Assessment Scale (DSAS-2)." Diabetes Care 39, no. 12 (2016): 2141–48. http://dx.doi.org/10.2337/dc16-0117.

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39

Saisho, Y. "Glycated Albumin: A More Sensitive Predictor of Cardiovascular Disease than Glycated Hemoglobin?" International Journal of Diabetology & Vascular Disease Research 1, no. 4e (2013): 1–2. https://doi.org/10.19070/2328-353X- 130004e.

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Type 2 diabetes is an established risk factor for cardiovascular disease (CVD). Compared to non-diabetic subjects, patients with type 2 diabetes have a 2 to 4-fold increased risk of development of CVD. Intensive glycemic control aiming at HbA1c below 7% has been shown to reduce the risk of development of microvascular disease in patients with type 2 diabetes; however, its effect on CVD was rather modest.

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40

Lu, Da-Yong, Jin-Yu Che, Nagendra Sastry Yarla, et al. "Type 2 Diabetes Study, Introduction and Perspective." Open Diabetes Journal 8, no. 1 (2018): 13–21. http://dx.doi.org/10.2174/1876524601808010013.

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Background:The prevalence of Type 2 Diabetes Mellitus (T2DM) continues to rise globally. The T2DM prevalence is not only in developing countries, but also in developed countries now. Correspondingly, the therapeutics of T2DM calls for a change (higher efficiency) due to growing number of patients and increasing economic burdens globally. Entering into this millennium, both piecemeal pathways (idea driven) and exponential growth of human genomic study are developing quickly. Genetypic-phenotypic translation, modern diagnostics, pharmacology, drug developments, traditional Chinese medicine, pers

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41

Ageeva, O. V., and M. V. Gatsu. "Macular telangiectasia type 2." Fyodorov journal of ophthalmic surgery, no. 3S (December 7, 2023): 102–8. http://dx.doi.org/10.25276/0235-4160-2023-3s-102-108.

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Purpose. To summarize the data on the etiology, pathogenesis, diagnostic methods, and treatment of macular telangiectasia type 2 (MacTel 2) currently known. Material and methods. For this review, a search was conducted on PubMed and eLIBRARY resources, covering scientific publications by domestic and foreign authors from 1980 to 2021. The primary focus of the search was on the topic of MacTel 2. Results. Based on the current understanding of the disease process, it is recognized that dysfunction or loss of Muller cells represents an early stage that contributes to the development of MacTel 2.

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42

William, G. Wuenstel, A. Johnson James, Humphries James, and Samuel Cheryl. "Ethnicity, Obesity, and Type 2 Diabetes of Adults in Urban Populations of Central America." International Journal of Public Health Science (IJPHS) 6, no. 1 (2017): 28~33. https://doi.org/10.11591/.v6i1.6529.

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The purpose of this meta-analysis was to examine the impact of ethnicity and obesity as it relates to Type-2 Diabetes (T2D) in specific Central American countries. A meta-analysis was conducted to determine the association of ethnicity, obesity, and T2D. Four studies that qualified for inclusion were identified by searching MEDLINE and PubMed databases. The studies on the association of ethnicity and T2D had a combined population resulted in 265,858 study participants. Two studies on the association of obesity and T2D had 197,899 participants. An analysis of the data was conducted utilizing th

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43

Kiseleva, T. A., F. V. Valeeva, and D. R. Islamova. "Personalized therapy of type 2 diabetes mellitus." Perm Medical Journal 40, no. 5 (2023): 73–79. http://dx.doi.org/10.17816/pmj40573-79.

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Currently, the contribution of genetic factors to the development of type 2 diabetes is becoming more obvious. Despite the available nine classes of hypoglycemic drugs, only 35–40 % of patients achieve an adequate glycemic control. One the reasons may be the genetic heterogeneity of diabetes mellitus. An increasing number of studies indicates that an individual set of gene polymorphisms can determine the therapeutic response to a particular drug and cause the development of undesirable effects. The article presents an overview of a new direction in the diagnosis and treatment of diabetes melli

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44

Kelly, Shona J., and Mubarak Ismail. "Stress and Type 2 Diabetes: A Review of How Stress Contributes to the Development of Type 2 Diabetes." Annual Review of Public Health 36, no. 1 (2015): 441–62. http://dx.doi.org/10.1146/annurev-publhealth-031914-122921.

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45

Langin, D. "The role of uncoupling protein 2 in the development of type 2 diabetes." Drugs of Today 39, no. 4 (2003): 287. http://dx.doi.org/10.1358/dot.2003.39.4.737960.

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46

Tahrani, Abd A., and Anthony H. Barnett. "Dapagliflozin: a sodium glucose cotransporter 2 inhibitor in development for type 2 diabetes." Diabetes Therapy 1, no. 2 (2010): 45–56. http://dx.doi.org/10.1007/s13300-010-0007-3.

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47

Katamadze, N., T. Kandashvili, and M. Noniashvili. "INFLUENCE OF DYSBACTERIOSIS ON DYSPEPSIA IN TYPE 2 DIABETIC PATIENTS." POLISH JOURNAL OF SCIENCE, no. 74 (May 15, 2024): 21–25. https://doi.org/10.5281/zenodo.11195231.

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The gastrointestinal tract is currently considered one of the large organs of the endocrine system. Although entero-endocrine cells make up only 1% of the total population of epithelial cells, unlike other cells, it produces more than 20 hormones. It was found that about 80% of the body's immune system is localized in the gastrointestinal tract. The ecosystem composition of the microbial community is dynamic and its composition depends on many factors. The intestinal barrier/permeability plays a critical role in the development of obesity and type 2 diabetes. The aim of our study was to determ

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48

Kos, K., and JPH Wilding. "New treatments for type 2 diabetes." Journal of the Royal College of Physicians of Edinburgh 39, no. 3 (2009): 227–30. https://doi.org/10.1177/1478271520093903020.

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Controlling blood glucose in type 2 diabetes remains challenging. All existing drugs have significant limitations and side effects, with some causing weight gain and thereby exacerbating the condition. This short review looks at new groups of drugs on the market and under development, and discusses their potential in the management of type 2 diabetes.

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49

Mamillapalli, Chaitanya, Ramesh Tentu, Nitesh Kumar Jain, and Ramanath Bhandari. "COPD and Type 2 Diabetes." Current Respiratory Medicine Reviews 15, no. 2 (2019): 112–19. http://dx.doi.org/10.2174/1573398x15666190211155640.

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COPD and Type 2 diabetes are two highly prevalent global health conditions associated with high mortality and morbidity. The connection between these two common diseases is complex, and more research is required for further understanding of these conditions. COPD is being increasingly recognized as a risk factor for the development of type2 diabetes through different mechanisms including systemic inflammation, obesity, hypoxia and use of corticosteroids. Also, hyperglycemia in diabetes patients is linked to the adverse impact on lung physiology, and a possible increase in the risk of COPD. In

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50

Loza, Matthew J., and Bice Perussia. "Peripheral Immature CD2−/lowT Cell Development from Type 2 to Type 1 Cytokine Production." Journal of Immunology 169, no. 6 (2002): 3061–68. http://dx.doi.org/10.4049/jimmunol.169.6.3061.

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