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1

Pilipenko, M. V. "Peptic ulcer." Spravočnik vrača obŝej praktiki (Journal of Family Medicine), no. 12 (November 30, 2023): 68–73. http://dx.doi.org/10.33920/med-10-2312-07.

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Peptic ulcer is a chronic relapsing disease that occurs with alternating periods of exacerbation and remission, the leading manifestation of which is the formation of a defect (ulcer) in the wall of the stomach and duodenum. It has been shown that 11-14% of men and 8-11% of women may develop peptic ulcer disease during their lifetime. Peptic ulcer localized in the duodenum occurs 4 times more frequently than peptic ulcer in the stomach. Among patients with duodenal ulcers, men predominate over women, while among patients with gastric ulcers, the ratio of men and women is approximately the same
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2

Kumari, Nitu, Vikas Mishra, and Priyanka. "An Anatomical Study of Pittadhara Kalaw.s.r Duodenal Ulcer -A Review." International Research Journal of Ayurveda & Yoga 06, no. 06 (2023): 118–21. http://dx.doi.org/10.47223/irjay.2023.6619.

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Ayurvedahas played important key role in Alternative Medicine, Traditional Ayurvedascience. In Ayurvedabasic principles like Tridosha, Panchmahabhuta,Dravyagunaare explained briefly. Acharyasushrutahas explained KalaSharirin 4thChapter of SharirasthanaGharbhashariramadhyaya. Total seven kala are present in the Human body and these are the limiting membranes between Dhatuand Aashaya. PittdharaKalais sixth in order, situated in between Pakwashayaand Amashya(i.e.Pakwaamashya). Pittdharakalacan be correlated with mucous membrane of small intestine. Upper part of small intestine is known as duodenu
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3

Vladimirova, Elizaveta, Lyubov Tveritneva, Era Beresneva, et al. "Diagnosis of perforation from the penetrating ulcer of the posterior wall of the duodenum." Hirurg (Surgeon), no. 5-6 (June 1, 2020): 38–52. http://dx.doi.org/10.33920/med-15-2003-02.

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The article is devoted to the problem of emergency surgery for abdominal organs – perforated ulcer of the posterior duodenal wall (duodenum). 140 patients with perforated duodenal ulcer were treated at the N.V. Sklifosovsky Research Institute for Emergency Medicine between 2016 and 2019. Eight patients had perforation from the penetrating ulcer of the posterior duodenal wall. The average age of patients with perforation from the penetrating ulcers in the posterior duodenal wall was 62.25 years (27 to 78 years). Most of the cases were found in men – 87.5%. 7 patients had surgery at the Institut
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4

Kharitonov, D. V., V. G. Sapozhnikov, and L. A. Kharitonova. "About the constitutional features of gastric and duodenal ulcer in children." Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) 67, no. 6 (2023): 63–67. http://dx.doi.org/10.21508/1027-4065-2022-67-6-63-67.

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Peptic ulcer disease is a fairly rare pathology of childhood. Therefore, it is important to analyze some features of peptic ulcer of the stomach and duodenum in children, depending on the body type.Purpose. To analyze some features of peptic ulcer of the stomach and duodenum in children, depending on the body type.Material and methods. We examined 58 children aged 12–18 years with a diagnosis of peptic ulcer of the stomach and/or duodenum, who underwent endoscopic examination, H. pylori was detected in the biopsy and aero test.Results. Peptic ulcer disease was more often detected in asthenic c
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5

Vakhrushev, Ya M., M. S. Busygina, and D. V. Opolonsky. "Treatment of patients with a duodenal ulcer with disorders of the motor evacuator function of the stomach and duodenal." Experimental and Clinical Gastroenterology, no. 3 (June 22, 2020): 47–53. http://dx.doi.org/10.31146/1682-8658-ecg-175-3-47-53.

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Aim. The study of disorders of the motor-evacuation function of the stomach and duodenum (duodenum) in patients with duodenal ulcer and their use in choosing effective therapy.Materials and methods. The study included 107 patients with ulcerous duodenal ulcer with the presence of motor-evacuation disorders of the gastroduodenal zone — group I and 99 patients with ulcerous duodenal ulcer without a violation of motor-evacuation function of the stomach and duodenum — group II. Anamnestic and physical data, results of X-ray and endoscopic examinations were used in verification of the ulcer. Assess
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6

Al Abri, MD, Maather, Ghaitha Al Mahruqi, MD, and Hani Al Qadhi, FRCSC. "Recurrent Peptic Ulcer Perforation: A Case Report." International Journal of Innovative Research in Medical Science 7, no. 01 (2022): 62–65. http://dx.doi.org/10.23958/ijirms/vol07-i01/1329.

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Background: Refractory peptic ulcers are ulcers in the stomach or duodenum that do not heal after eight to twelve weeks of medical/surgical treatment or those that are associated with complications despite medical tssreatment. We herein present a case of a 44 year old man with a recurrent perforated duodenal ulcer requiring emergent surgical intervention.
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7

Kharitonov, D. V., V. G. Sapozhnikov, and L. A. Kharitonova. "About the constitutional features of gastric and duodenal ulcer in children." Experimental and Clinical Gastroenterology, no. 6 (November 21, 2022): 36–40. http://dx.doi.org/10.31146/1682-8658-ecg-202-6-36-40.

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The goal of research. To analyze some features of peptic ulcer of the stomach and duodenum in children, depending on the type of constitution. Material and methods of research. We examined 58 children aged 12-18 years with a diagnosis of peptic ulcer of the stomach and/or duodenum, who underwent endoscopic examination, Hp was detected in the biopsy and aero test. Results. Peptic ulcer disease was more often detected in asthenic children (67.2%), less often in hypersthenic (17.3%) and normosthenics (15.5%). Various research methods in asthenic children (97.4%) revealed the presence of Hp more o
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8

SAKHABETDINOVA, KAMILIA N., BULAT A. SAKHABETDINOV, and NAIL B. AMIROV. "COMORBIDITY AS A FACTOR OF GASTRODUODENAL ULCER DEVELOPMENT IN ELDERLY AND SENILE PATIENTS." Bulletin of Contemporary Clinical Medicine 17, no. 6 (2024): 84–96. https://doi.org/10.20969/vskm.2024.17(6).84-96.

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Introduction. Peptic ulcer disease is a chronic recurrent multifactorial disease that takes its course with alternating exacerbations and remissions and is manifested by ulcerative defects in the mucous membrane of the stomach and duodenum, which is based on an imbalance of aggressive and protective factors with a predominance of ВЕСТНИК СОВРЕМЕННОЙ КЛИНИЧЕСКОЙ МЕДИЦИНЫ 2024 Том 17, вып. 6 85ОБЗОРЫ the former ones. Of particular interest is the comparative characteristics of gastric and duodenal ulcers in the patients of senile and elderly age groups due to their pathogenetic features and sing
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9

Arava Vidyadhari, Thatiparthi Siva prasad, Mangala Teja Divya, et al. "To study the Helicobacter pylori infection in peptic ulcer." World Journal of Advanced Research and Reviews 22, no. 1 (2024): 1801–8. http://dx.doi.org/10.30574/wjarr.2024.22.1.1098.

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Helicobacter pylori is a gram negative bacterium which causes chronic gastritis and plays important roles in peptic ulcer disease, gastric carcinoma, and gastric lymphoma. Its major in the human pathogen that produces inflammation of the stomach and etiologically related to the duodenal ulcer, gastric ulcer, gastric cancer and mucosa-lymphoid tissue. It is weakens the protective mucous coating of the stomach and duodenum, thus allowing acid to get through to the sensitive lining beneath. Both the acid and the bacteria irritate the lining and cause a sore, or ulcer. Helicobacter treated with a
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10

Arava, Vidyadhari, Siva prasad Thatiparthi, Teja Divya Mangala, et al. "To study the Helicobacter pylori infection in peptic ulcer." World Journal of Advanced Research and Reviews 22, no. 1 (2024): 1801–8. https://doi.org/10.5281/zenodo.14237951.

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Helicobacter pylori is a gram negative bacterium which causes chronic gastritis and plays important roles in peptic ulcer disease, gastric carcinoma, and gastric lymphoma. Its major in the human pathogen that produces inflammation of the stomach and etiologically related to the duodenal ulcer, gastric ulcer, gastric cancer and mucosa-lymphoid tissue. It is weakens the protective mucous coating of the stomach and duodenum, thus allowing acid to get through to the sensitive lining beneath. Both the acid and the bacteria irritate the lining and cause a sore, or ulcer. Helicobacter treated with a
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11

Anand, Shubham, Namrata Mishra, Namrata Mishra, Manoj Kumar Bajhaiya, and Nisha Verma. "A comprehensive review of the mechanism of action in peptic ulcer pathogenesis." Future Journal of Pharmaceuticals and Health Sciences 4, no. 4 (2024): 1–9. http://dx.doi.org/10.26452/fjphs.v4i4.656.

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Up to 10% of people worldwide suffer from peptic ulcer disease, making it a common yet serious chronic condition. Peptic ulcers develop when stomach juice pH is high and mucosal defenses are weakened. The infection with Helicobacter pylori (H.) and nonsteroidal anti-inflammatory medicines (NSAIDs) have been linked to decreased mucosal resilience to damage. Internal gastrointestinal (GI) disruption due to the production of gastric acid or pepsin is what defines peptic ulcer disease (PUD). The stomach and the first part of the duodenum are common sites for the phenomenon. The jejunum, distal duo
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12

RaviKKumar, V. R., Sanjesh Rathi, Shubham Singh, et al. "A Comprehensive Review on Ulcer and Their Treatment." Chinese Journal of Applied Physiology 39 (2023): e20230006. http://dx.doi.org/10.62958/j.cjap.2023.006.

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A peptic ulcer is a lesion (sore) on the stomach lining, or duodenum. Peptic ulcers are probably a twentieth-century condition. The ulcer disease continues to be a significant source of worldwide morbidity and mortality. The Gastrointestinal ulcers and duodenal ulcers are considered the two most extreme types of peptic ulcers. Peptic ulcers are found to be caused by an excess of violent factors including Hydrochloric acid (HCL) pepsin, refluxed bile leukotrienes (LT), reactive oxygen species (ROS) and protective factors, these include mucus-bicarbonate barrier functions, prostaglandins (PGs),
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13

Aslam, Hamid Khan Mohd Altaf Dar Mashooq Ahmad Mir. "Gastric Ulcer: An overview." International Journal of Current Research in Physiology and Pharmacology (IJCRPP) 7, no. 3 (2023): 1–7. https://doi.org/10.5281/zenodo.7820641.

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Gastric ulcers are breaks in the mucosa of the stomach lining that penetrate through the muscularis mucosa and extend more than 5 mm in diameter. When alterations occur to the defense mechanisms of the stomach, it can cause changes in the gastric mucosa, eventually resulting in erosion and then ulceration. Non-steroidal anti-inflammatory drugs (NSAIDs) and Helicobacter pylori (H. pylori) infection are the two major factors disrupting mucosal resistance to injury. Gastric ulcers are characterized by discontinuation in the inner lining of the gastrointestinal (GI) tract because of gastric acid s
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14

Buzdugan, I., V. Potochniak, M. Melnychuk, and Y. Mohyla. "ASSESSMENT OF THE PROPERTIES OF AIR ON THE STATE OF THE MUCOUS MEMBRANE OF THE DUODENUM IN PATIENTS WITH PEPTIC ULCER WITH ARTERIAL HYPERTENSION AND DIABETES TYPE 2." Znanstvena misel journal, no. 78 (May 29, 2023): 44–46. https://doi.org/10.5281/zenodo.7980651.

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The article highlights the changes in the mucous membrane of the duodenum in patients with peptic ulcer with arterial hypertension and diabetes type 2, namely a decrease in the secretion of protective mucus. Given the healing properties of air, it can be said that air is an additional remedy in the treatment of duodenal ulcers.
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15

Kohda, K., K. Tanaka, Y. Aiba, M. Yasuda, T. Miwa, and Y. Koga. "Role of apoptosis induced by Helicobacter pylori infection in the development of duodenal ulcer." Gut 44, no. 4 (1999): 456–62. http://dx.doi.org/10.1136/gut.44.4.456.

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BACKGROUNDHelicobacter pylori affects gastric epithelium integrity by acceleration of apoptosis. However, it remains unclear what product of the bacteria causes apoptosis, or whether or not the apoptosis is involved in the development of ulcers.AIMSTo elucidate the factor from H pylori that causes acceleration of apoptosis and the role of apoptosis in the development of duodenal ulcer in H pylori infection.PATIENTSFiveH pylori negative healthy volunteers, 47H pylori positive patients with duodenal ulcer, and 35 H pylori positive patients with gastric ulcer.METHODSAn endoscopic examination was
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16

Bhagwan, Raghunath Korde, and Ganeshrao Patil Kapildev. "Clinical Study on Patients with Duodenal Perforation." International Journal of Toxicological and Pharmacological Research 13, no. 11 (2023): 1–5. https://doi.org/10.5281/zenodo.10995579.

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<strong>Background:&nbsp;</strong>Due to patient delays, surgical delays, and a shortage of antibiotics, perforated duodenal ulcers, the most serious consequence, used to have a high death rate. According to several writers, during the previous three decades, there has been a decrease in the incidence of peptic ulcer illness and perforation. The treatment of peptic ulcer disease has changed, and surgery has become less necessary as a result of advancements in the use of a variety of medications in medical therapy. Males are more likely to experience perforation in their third and fourth decade
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17

Hien, Dang Thi Thu, Dinh Thi Thu Trang, Do Linh Quyen, et al. "Evaluation of the protective effect of agar-hp hard capsule for peptic ulcer in experimental animals." Tạp chí Nghiên cứu Y học 161, no. 12E11 (2023): 135–42. http://dx.doi.org/10.52852/tcncyh.v161i12e11.1181.

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Imbalance between exogenous damaging agents and protective factors in the gastro-duodenum tract can lead to peptic ulcer disease. Herbal medicines could be an effective treatment to human gastric ulcers. This study aimed to investigate the protective effect of AGAR-HP hard capsules on cysteamine-induced gastric-duodenal ulcers in experimental rats. The animals were divided into five treatment groups: Group 1 (control) and group 2 (model) were treated with distilled water, group 3 received esomeprazole at 10 mg/kg, group 4 received AGAR-HP at 0.074 g/kg, and group 5 received AGAR-HP at 0.221 g/
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18

Triantafyllou, Tania, Kokoroskos Nikolaos, Papailiou Joanna, Linardoutsos Dimitrios, Zografos Georgios, and Theodorou Dimitrios. "Double Perforated Kissing Ulcers of Duodenum: A Brief Report." International Surgery 103, no. 1-2 (2019): 36–39. http://dx.doi.org/10.9738/intsurg-d-15-00280.1.

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Helicobactor pylori infection has been associated with peptic ulcer disease and is currently treated with proton pump inhibitors (PPIs), which have reduced the complications of the disease. Perforation of either a gastric or duodenal ulcer is rarely treated with surgery. We report the case of double-perforated synchronous duodenal ulcers, which is an extremely infrequent condition. To our knowledge, no English case reports have yet been published. Therefore, awareness of the physician in the field of diagnosis and treatment of this peptic ulcer is required. We report the case of a 46-year-old
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19

Lutenco, Valerii, Adrian Beznea, Raul Mihailov, Ioana Anca Stefanopol, Valentin Bulza, and Liliana Baroiu. "Review of Toxic Chemical Factors Influence in Gastric and Duodenal Ulcers." ARS Medica Tomitana 29, no. 2 (2023): 112–16. http://dx.doi.org/10.2478/arsm-2023-0017.

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ABSTRACT Peptic ulcer is a lesion most often located in the stomach or the proximal duodenum. The incidence, the hospitalization rate and the associated mortality in the last decades is decreasing due to modern therapy and hygiene measures. Approximately half of the population is colonized by H. Pylori, which is one of the main causes of ulcers. Other contributing factors are diet and stress. Non-steroidal anti-inflammatories cause damage to the gastro-duodenal mucosa by inhibiting cyclooxygenase-1. Concomitant consumption of proton pump inhibitors can be a solution. Natural evolution can lead
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20

Shishido, Yutaka, Eisei Mitsuoka, Yuma Tanigawa, et al. "Duodenal ulcer bleeding from a branch of the middle colic artery: A case report." Medicine 102, no. 44 (2023): e35955. http://dx.doi.org/10.1097/md.0000000000035955.

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Rationale: Duodenal ulcer bleeding is a potentially life-threatening condition commonly caused by the erosion of the duodenal arteries. Patient concerns: A 55-year-old male was referred to our hospital with abdominal pain for the past 3 days. Contrast-enhanced computed tomography of the abdomen revealed wall thickening in the descending part of the duodenum and a cystic lesion (27 × 19 mm) contiguous with the duodenum, with an accumulation of fluid. An esophagogastroduodenoscopy showed the significantly stenotic duodenum, which prevented passage of the endoscope and evaluation of the main lesi
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Marsh, Amanda M., Ayman Almousa, Thomas Genuit, David Forcione, and Karin Blumofe. "Bile Leak following Laparoscopic Cholecystectomy due to Perforated Duodenal Ulcer in Patient with Roux-en-Y Gastric Bypass." Case Reports in Surgery 2021 (August 3, 2021): 1–4. http://dx.doi.org/10.1155/2021/6662433.

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Perforated ulcers of the excluded stomach or duodenum are exceedingly rare in patients who have undergone Roux-en-Y gastric bypass surgery. The diagnosis of perforated ulcer after Roux-en-Y gastric bypass remains challenging as there is often absence of free air or contrast extravasation from the biliopancreatic limb. We present a patient with signs and symptoms of acute cholecystitis. Laparoscopic cholecystectomy was complicated by postoperative bile leak. EDGE procedure was performed to access the remnant stomach and endoscopic evaluation revealed a perforated ulcer in the posterior duodenal
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22

Barannikov, S. V., E. F. Cherednikov, G. V. Polubkova, et al. "First experience of using alginate polymer polysaccharide hemostatic hydrogel in complex endoscopic treatment of unstable gastroduodenal ulcer bleeding: Clinical cases." Kuban Scientific Medical Bulletin 31, no. 3 (2024): 73–92. http://dx.doi.org/10.25207/1608-6228-2024-31-3-73-92.

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Background. Gastroduodenal ulcer bleeding continues to be a serious problem in modern emergency surgery. Early intensive therapy combined with endoscopic hemostasis remains crucial for successful treatment of patients with ulcerative hemorrhages. The problem of recurrent bleeding, which is recorded in 12–33% of cases, even when using combined methods of endoscopic hemostasis, is still the most difficult challenge in the treatment of patients with ulcerative bleeding. The search for new approaches in the endoscopic treatment of bleeding gastroduodenal ulcers is considered to be highly relevant.
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Maksymchuk, D., V. Mamchych, and V. Maksymchuk. "Surgical treatment of complicated duodenal ulcers with different variants of their localization." Journal of Education, Health and Sport 11, no. 9 (2021): 773–80. http://dx.doi.org/10.12775/jehs.2021.11.09.093.

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Purpose: To analyze and highlight the most effective methods of surgical treatment of complicated duodenal ulcer (DU) depending on its location. Material and methods. 86 patients underwent surgery for complicated combined pyloroduodenal ulcers. All patients with signs of gastrointestinal bleeding and perforation were examined according to clinical protocols. Patients were operated on by various surgical techniques depending on the location of DU. Further the analysis of different methods of surgical treatment of the pathology under study at its various localizations was carried out. Results. I
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Herrod, PJJ, D. Kamali, and SCB Pillai. "Triple-ostomy: management of perforations to the second part of the duodenum in patients unfit for definitive surgery." Annals of The Royal College of Surgeons of England 93, no. 7 (2011): e122-e124. http://dx.doi.org/10.1308/147870811x602320.

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Peptic ulcers in the second part of the duodenum are a rare occurrence and present challenging management. Conventional surgical operations are associated with life threatening complications. We describe a case of a perforated duodenal ulcer in a medically unstable patient who was deemed unfit for lengthy definitive surgery. An emergency laparotomy and ’triple-ostomy’ was performed. We recommend this procedure as an alternative for the emergency repair of D2 ulcers, especially in patients with multiple co-morbidities.
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Strömberg, E., A. Edebo, A. M. Svennerholm, and C. Lindholm. "Decreased Epithelial Cytokine Responses in the Duodenal Mucosa of Helicobacter pylori-Infected Duodenal Ulcer Patients." Clinical Diagnostic Laboratory Immunology 10, no. 1 (2003): 116–24. http://dx.doi.org/10.1128/cdli.10.1.116-124.2003.

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ABSTRACT Helicobacter pylori colonizes the human stomach and areas of gastric metaplasia in the duodenum, but only a minority of those that are infected develop symptoms, e.g., peptic ulcers. Although most ulcers occur in the duodenum, almost all studies of mucosal immune responses against the infection have been limited to responses in the stomach. In the present study we evaluated whether there are differences in the levels of proinflammatory cytokines as well as immunoregulatory cytokines in the duodenal mucosa of duodenal ulcer (DU) patients and asymptomatic (AS) carriers which may be rela
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Ibatova, Sh.M. Islamova D.S. Rakhmonov Yu.A. "CLINIC, DIAGNOSTICS AND TREATMENT OF DUODENAL ULCER IN CHILDREN." EURASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES 3, no. 6 (2023): 216–19. https://doi.org/10.5281/zenodo.8049991.

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The following factors play a role in the development of duodenal ulcer in children: neuropsychic, endocrine, hereditary and constitutional factors, drug and toxic effects, food allergies, malnutrition and the infectious agent Helicobacter pylori is of paramount importance in the formation of ulcers. Often the disease occurs with frequent prolonged exacerbations and in a more severe form, which contributes to the development of complications. Peptic ulcer of the duodenum in adolescents has its own age characteristics and determines the need for a differentiated approach to the treatment of pati
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Sivakumar, Aran, and Benjamin Stubbs. "Peptic ulcer disease." InnovAiT: Education and inspiration for general practice 14, no. 6 (2021): 372–78. http://dx.doi.org/10.1177/17557380211005791.

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Peptic ulcer disease (PUD) is defined as a disruption in the innermost lining of the gastrointestinal tract, due to the secretion of gastric acid or pepsin. The disruption is in the gastric epithelial layer, specifically the muscularis mucosae. PUD normally affects the stomach along with the first and second parts of the duodenum, although it is not limited to these areas. Typically, gastric ulcers induce upper abdominal pain within 30 minutes of eating, whereas duodenal ulcers cause discomfort much later. Endoscopic and histological investigations are the key to early identification and treat
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Tukhbatullin, M. G. "Possibilities of gastric ultrasound." Kazan medical journal 77, no. 3 (1996): 218–19. http://dx.doi.org/10.17816/kazmj104457.

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Indications for gastric ultrasound are peptic ulcer and duodenal ulcer, benign and malignant neoplasms of the stomach, gastrointestinal dyskinesia, gastritis, monitoring the effectiveness of the ongoing therapy and clarification of the diagnosis in various diseases of the stomach and duodenum, refusal of the patient fibrogastroscopy.
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Kartheek, Chegu* Innaiah Nallaboina Divya Billi Ajay Babu Palaparthi. "A REVIEW ON SOME HOME REMEDIES ACT AS GASRTOPROTECTIVE ACTIVITY." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 02 (2019): 4640–43. https://doi.org/10.5281/zenodo.2581500.

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<em>Ulcer is a common gastrointestinal disorder which is seen among many people. It is basically an inflamed break in the skin or the mucus membrane lining the alimentary tract.</em><em> Peptic ulcers include Gastric ulcers&nbsp;that occur on the inside of the stomach and duodenal ulcers&nbsp;that occur on the inside of the upper portion of your small intestine (duodenum). The most common causes of peptic ulcers are infection with the bacterium Helicobacter pylori (H. pylori) and long-term use of aspirin and certain other painkillers, such as ibuprofen and naproxen sodium. The most common pept
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Lim, Jung-Hyun, Jongbeom Shin, and Jin-Seok Park. "Effect of a Proton Pump Inhibitor on the Duodenum Microbiome of Gastric Ulcer Patients." Life 12, no. 10 (2022): 1505. http://dx.doi.org/10.3390/life12101505.

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The gut microbiota are regarded as a functional organ that plays a substantial role in human health and disease. Proton pump inhibitors (PPIs) are widely used in medicine but can induce changes in the overall gut microbiome and cause disease-associated dysbiosis. The microbiome of the duodenum has not been sufficiently studied, and the effects of PPIs on the duodenal microbiome are poorly understood. In this study, we investigated the effect of PPI administration on duodenum microbiota in patients with a gastric ulcer. A total of 12 gastric ulcer patients were included, and PPI (Ilaprazole, No
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Tundis, Rosa, Monica R. Loizzo, Marco Bonesi, et al. "Natural Products as Gastroprotective and Antiulcer Agents: Recent Developments." Natural Product Communications 3, no. 12 (2008): 1934578X0800301. http://dx.doi.org/10.1177/1934578x0800301234.

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Peptic ulcer, one of the most common gastrointestinal diseases, is a chronic inflammatory disease characterized by ulceration in the regions of the upper gastrointestinal tract where parietal cells are found and where they secrete hydrochloric acid and pepsin. The anatomical sites where ulcer occurs commonly are stomach and duodenum, causing gastric and duodenal ulcer, respectively. Physiopathology of ulcer is due to an imbalance between aggressive factors, such as acid, pepsin, Helicobacter pylori and non-steroidal anti-inflammatory agents, and local mucosal defensive factors, such as mucus b
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32

Peregudov, Sergey I., and Son T. Luong. "Complicated postbulbar duodenal ulcers: peculiar clinical features, diagnosis and treatment." Bulletin of the Russian Military Medical Academy 26, no. 3 (2024): 447–60. http://dx.doi.org/10.17816/brmma630920.

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Domestic and foreign studies have examined the clinical manifestations, diagnosis, and surgical treatment of patients with complicated bulbous duodenal ulcers. Elibrary.ru, the Russian National Library, and PubMed were searched for relevant scientific medical literature published between 1926 and 2023. The search focused on literature data on evidence-based medicine. Bulbous peptic ulcers occurred in 3.6–17% with duodenal ulcers. It often has an atypical clinical course and is at risk of severe complications such as ulcerative bleeding, decompensated duodenal stenosis, and ulceration. Surgical
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Ahtshamullah, Chaudhr, Morton Cuthrell Kimberly, and R. Thornton Owen. "Peptic Ulcer Disease; Stomach and Gastric Ulcers, a Concise Review." International Research Journal of Gastroenterology and Hepatology 6, no. 1 (2023): 30–39. https://doi.org/10.5281/zenodo.7737740.

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The most prevalent condition affecting the stomach and duodenum is peptic ulcer disease (PUD), which is linked to Helicobacter pylori (H. pylori) infection. Esophageal, duodenal, and stomach ulcers are all parts of peptic ulcer disease (PUD). Epigastric discomfort is the PUD symptom that commonly occurs. Proton Pump Inhibitors (PPI), Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), and antibiotics are widely used to treat PUD, which is caused by an imbalance between offensive and defensive forces. Abdominal discomfort, nausea, vomiting, weight loss, and bleeding or perforation with the complicat
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Ahtshamullah, Chaudhry, Morton Cuthrell Kimberly, and R. Thornton Owen. "Peptic Ulcer Disease; Stomach and Gastric Ulcers, a Concise Review." International Research Journal of Gastroenterology and Hepatology 6, no. 1 (2023): 30–39. https://doi.org/10.59283/IRJGH.

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The most prevalent condition affecting the stomach and duodenum is peptic ulcer disease (PUD), which is linked to Helicobacter pylori (H. pylori) infection. Esophageal, duodenal, and stomach ulcers are all parts of peptic ulcer disease (PUD). Epigastric discomfort is the PUD symptom that commonly occurs. Proton Pump Inhibitors (PPI), Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), and antibiotics are widely used to treat PUD, which is caused by an imbalance between offensive and defensive forces. Abdominal discomfort, nausea, vomiting, weight loss, and bleeding or perforation with the complicat
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35

Sharapov Ilkhomberdi Kamalovich. "Modern Methods of Surgical Treatment of Gastric Ulcer and Duodenal Ulcer." Texas Journal of Medical Science 15 (December 14, 2022): 91–95. http://dx.doi.org/10.62480/tjms.2022.vol15.pp91-95.

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More than a century has passed since the production of the first perforating ulcer suturing operation in world practice. During this period, many researchers have put a lot of work into finding ways to reduce mortality and postoperative complications in perforated ulcers of the stomach and duodenum.
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Sharapov, Ilkhomberdi Kamalovich. "MODERN METHODS OF SURGICAL TREATMENT OF GASTRIC ULCER AND DUODENAL ULCER." EURASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES 3, no. 1 (2023): 42–48. https://doi.org/10.5281/zenodo.7512271.

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More than a century has passed since the production of the first perforating ulcer suturing operation in world practice. During this period, many researchers have put a lot of work into finding ways to reduce mortality and postoperative complications in perforated ulcers of the stomach and duodenum.
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37

Wani, Sajad A., Gowhar N. Mufti, Nisar A. Bhat, Aejaz A. Baba, and Sheikh Khursheed. "Duodenal ulcer complicated with choledochoduodenal fistula and pneumobilia in a young child: A very rare case report." Journal of Medical Research 1, no. 6 (2015): 156–57. http://dx.doi.org/10.31254/jmr.2015.1601.

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Spontaneous pneumobilia is the disease of elderly, usually results from abnormal biliary-enteric communication mostly as a consequence of cholelithiasis related gall bladder perforation in to the normal duodenum. Pneumobilia due to choledochoduodenal fistula (CDF) from duodenal ulcer is quite rare nowadays due to the low prevalence of peptic ulcer disease and has not been reported in children. We reported a case of duodenal ulcer related CDF with pneumobilia in a young child. Medical management is effective in such cases and surgery is indicated in cases of poorly controlled symptoms or compli
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Abdullaevich, Berdiev Ergash, Atakov Sarvar Sultanbaevich, Faizullaev Tajiddin Sulaymonovich, Kasimov Ulugbek Korkmasovich, and Mukhidinov Abdulla Umidilloevich. "POSSIBILITIES OF TREATING PERFORMATIVE ULCERS OF THE STOMACH AND DUODENUM BY MEANS OF ENDOVIDEOSURGERY." International Journal of Medical Sciences And Clinical Research 4, no. 2 (2024): 59–63. http://dx.doi.org/10.37547/ijmscr/volume04issue02-08.

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The article presents the results of treatment of gastric and duodenal ulcer perforation and its complications in 35 children aged 12 to 18 years. Cases of videolaparoscopic removal of gastric and duodenal ulcers performed in these patientsIn 27 (77.2%) cases, it was successfully completed, and in 3 (8.6%) cases, conversion occurred. Traditional "open" surgical interventions were performed in 5 (14.2%) patients. The information content of ultrasound and X-ray methods of preoperative diagnosis was evaluated. In particular, the specific course of the disease and the results of diagnosis and treat
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39

International, Journal of Medical Science and Advanced Clinical Research (IJMACR). "Comparative Study of Laparoscopic vs Conventional Duodenal Ulcer Perforation Surgery." International Journal of Medical Science and Advanced Clinical Research (IJMACR) 8, no. 1 (2025): 187–200. https://doi.org/10.5281/zenodo.15228504.

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<strong>Abstract</strong> <strong>Introduction: </strong>Duodenal perforation is a common complication of duodenal ulcer. Duodenal ulcers are part of a broader disease state categorized as peptic ulcer disease. Peptic ulcer disease refers to the clinical presentation and disease state that occurs when there is a disruption in the mucosal surface at the level of the stomach or first part of the small intestine, the duodenum. The present study was conducted to determine whether the minimal access approach by laparoscopy was equally feasible as the open method. <strong>Aims and Objectives: </stro
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Başak, Ahmet, and Turgut Anuk. "Non-Traumatic Full-Thickness Duodenal Perforation: a Case Report." Ağrı Tıp Fakültesi Dergisi 2, no. 2 (2024): 71–74. http://dx.doi.org/10.61845/agrimedical.1409939.

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Duodenal perforation is a life-threatening condition with high mortality and morbidity. In this study, we aim to present a case of spontaneous duodenal perforation that was detected and treated. The 66-year-old male patient, who applied to the emergency clinic with complaints of malaise, fever, weakness and shortness of breath, had no additional disease other than Chronic obstructive pulmonary disease and dementia. Pneumonia was diagnosed based on physical examination and imaging findings, and he was admitted to the pulmonology clinic and treated. During follow-ups, the patient developed sepsi
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Sagdati, S., and S. Milinić. "HELICOBACTER PYLORI INFECTION AND ASSOCIATED DISEASE AT DIFFERENT AGES AND SEX." Praxis medica 38, no. 1 (2010): 87–90. http://dx.doi.org/10.70949/pramed201001333s.

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&amp;lt;p&amp;gt;The discovery of Helicobacter pylori (Hp) and the causal relationship between Helicobacter pylori infection with chronic gastritis, gastric and duodenal ulcers and gastric cancer is an epochal event in recent times. The aim of this study was to examine the prevalence of Hp infection and prove the connection between Helicobacter pylori infection and gastric and duodenal diseases in different age and gender categories. Study included 250 subjects of both sexes, different age groups selected random sample. All respondents were subjected to Hp urease test from biopsy specimens of
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Wei, Hualin, Wei Han, Xianbo Zhang, and Ming Zhang. "Gastroscopic observation and dose-volume histogram parameter study on gastrointestinal mucous injury for pancreatic cancer treated with TOMO." Medicine 103, no. 25 (2024): e38469. http://dx.doi.org/10.1097/md.0000000000038469.

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To explore the relationships between gastrointestinal radiation injuries of pancreatic cancer patients treated with TOMO and dose-volume histogram parameters prospectively. Seventy patients with pancreatic cancer who underwent TOMO were enrolled in this prospective study from February 2015 to May 2020. The clinical and dose-volume histogram parameters of the patients were collected. The optimal dose parameters for gastrointestinal radiation ulcers were confirmed based on the receiver operating characteristic curve (ROC) and the area below the ROC curve. Acute gastrointestinal tract toxic and s
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Kadyrov, D. M., Z. V. Tabarov, F. D. Kodirov, Sh Sh Saidaliev, and V. Sh Sharipov. "Multiple complications of postbulbar parapapillary ulcer combined with arteriomesenteric compression of the duodenum." Health care of Tajikistan, no. 3 (November 13, 2022): 83–89. http://dx.doi.org/10.52888/0514-2515-2022-354-3-83-89.

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The article explores a clinical observation of a giant postbulbar parapapillary duodenal ulcer with multiple combined complications in the form of penetration into the pancreas, acute gastroduodenal bleeding and subcompensated stenosis occurred against the background of arterio-mesenteric compression of the duodenum in the subcompensation stage. The long course of the disease contributed to the development of alimentary dystrophy, cachexia and severe anemia. After stopping the bleeding, carrying out adequate preoperative preparation, the patient underwent Roux-en-Y gastric resection to “turn o
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Belokonev, V. I., S. Yu Pushkin, K. P. Yadav, and A. A. Serov. "Current trends in the treatment of complications in patients with gastric and duodenal ulcer disease (review of foreign literature)." Bulletin of the Medical Institute "REAVIZ" (REHABILITATION, DOCTOR AND HEALTH) 14, no. 6 (2025): 67–72. https://doi.org/10.20340/vmi-rvz.2024.6.clin.3.

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Relevance. Peptic ulcer disease is a common disease that occurs in 5–10 % of the world population. Despite the sharp decrease in morbidity and hospitalization rates of patients with peptic ulcer disease of the stomach and duodenum, for the last 30 years lethality in such patients remains at a high level, and complications occur with a frequency of 10–20 %. Purpose: to present the literature review of foreign researchers devoted to the modern trends of complications treatment in patients with peptic ulcer and duodenal ulcer disease. Material and methods. Literature sources in English on this to
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Santos-Rancaño, Rocio, Esteban Martín Antona, and José Vicente Méndez Montero. "A Challenging Case of a Large Gastroduodenal Artery Pseudoaneurysm after Surgery of a Peptic Ulcer." Case Reports in Surgery 2015 (2015): 1–3. http://dx.doi.org/10.1155/2015/370937.

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We report a 48-year-old man in whom a chronic postbulbar duodenal ulcer destroyed much of the back wall of the duodenum and gastroduodenal artery causing pseudoaneurysm. The lesion was found and evaluated by contrast-enhanced computed tomography (that revealed a large pseudoaneurysm of 83 mm×75 mm in diameter) and by angiography and then treated with transcatheter embolization leading to a complete resolution of the lesion. The case is rare and important for several reasons. First, we demonstrate that pseudoaneurysm of the gastroduodenal artery caused by a duodenal ulcer can occur and present
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Vandana1*, Pooja Solanki2 Ankit Dahiya3 Rajashekar Kamalla4 and Varun Kumar Sarkar5. "" Zollinger-Ellison syndrome in dogs "." Trends In Agriculture Science 2, no. 7 (2023): 541–45. https://doi.org/10.5281/zenodo.8184375.

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<strong>Zollinger-Ellison syndrome </strong>is a rare disorder caused by a tumor called a gastrinoma. The tumor secretes the hormone gastrin, which causes excess production of gastric acid, leading to severe recurrent ulcers of the esophagus, stomach, duodenum, and jejunum. The syndrome is characterized by severe peptic ulcer disease caused by gastrin-secreting neuroendocrine tumors, most commonly located in the <strong>duodenum and pancreas</strong>. Frequently gastrinomas are not recognized at initial clinical presentation and are often mistreated. Symptoms that should raise suspicion of a g
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47

Gasimov, N. A., N. I. Mammadov, I. K. Akberova, and A. E. Hajieva. "IMMEDIATE RESULTS OF MINIMALLY INVASIVE SURGERY FOR COMPLICATED PEPTIC ULCERS OF THE STOMACH AND DUODENUM." Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 24, no. 2 (2024): 10–17. http://dx.doi.org/10.31718/2077-1096.24.2.10.

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Objective: To enhance the immediate treatment outcomes of complicated peptic ulcers of the stomach and duodenum through the development and application of video-assisted organ-preserving surgeries. Materials and Methods: This study analyzed the treatment outcomes of 261 patients with complicated gastric and duodenal ulcers. The patients received the treatment in the surgical departments of Azerbaijan State Advanced Training Institute for Doctors named after A. Aliyev, Scientific Surgical Center named after M.A. Topchubashev, and Sabunchi Medical Center from 2015 to 2023. All patients with perf
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Rusyaev, V. Yu, D. A. Sheptulin, N. V. Shulpekova, and Yu O. Shulpekova. "Rabeprazole in the treatment of duodenal ulcer desease and functional dyspepsia." Medical Council, no. 12 (July 29, 2018): 70–76. http://dx.doi.org/10.21518/2079-701x-2018-12-70-76.

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The review aims to provide a contemporary view of the pathogenesis and treatment of the most common duodenum diseases – duodenal ulcer disease (DUD) and functional dyspepsia (FD). Due to its unique structure and functions, the duodenum that anatomically represents the initial section of the small intestine differentiates itself from others. The prevalence of DUD is declining in many Western countries due to the widespread introduction of effective anti-Helicobacter therapy and a significant decrease in the prevalence of H pylori infection. However, the ideas about the poly-biological nature of
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Kumar, Akhilesh, Dhanesh Kumar, Rajendra Kumar, et al. "Peptic Ulcers and their Complications." Journal of Drug Delivery and Therapeutics 10, no. 3-s (2020): 256–61. http://dx.doi.org/10.22270/jddt.v10i3-s.4082.

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Peptic ulcer disease (PUD) is an uncommon disorder of early life. Peptic ulceration of the stomach or duodenum is usually associated with abnormalities of the gastric mucosa such as gastritis and/or gastropathy. Gastritis and ulcers of the stomach and duodenum can be classified into either primary or secondary depending on their aetiologies. The majority of primary or unexplained peptic ulcers are the result of chronic inflammation caused by Helicobacter pylori infection. However, an increasing number of children with PUD without evidence of H. Pylori infection are now being seen. Rarely PUD i
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Pattewar, S.G. Sakhare R. S. Nagoba Shivappa N. Sugave B. K. Moholkar Aparark V. "A REVIEW: TRADITIONAL ANTIULCER COMPOUNDS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 06, no. 01 (2019): 911–17. https://doi.org/10.5281/zenodo.2538342.

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<em>Peptic ulcer is a break in the lining of the stomach, first part of the small intestine, or duodenum. The duodenumis the first part of the small intestine. Incompatible to popular belief, ulcers are not caused by spicy food or stress but other factors causes&rsquo; peptic ulcer main cause of peptic ulcer called H. pylori bacterial infection and long term use of NSAIDS medication. The main goals for treating a peptic ulcer include eliminating the underlying cause (particularly H. pylori infection or use of NSAIDs), NSAIDs inhibit the cyclooxygenase enzyme, Cyclooxygenase stop the secretion
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