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Journal articles on the topic 'Undergoes stress'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Tanaka, Arowu R., Fumi Kano, Kazumitsu Ueda, and Masayuki Murata. "The ABCA1 Q597R mutant undergoes trafficking from the ER upon ER stress." Biochemical and Biophysical Research Communications 369, no. 4 (2008): 1174–78. http://dx.doi.org/10.1016/j.bbrc.2008.03.018.

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2

Karyappa, Rahul B., Shivraj D. Deshmukh, and Rochish M. Thaokar. "Breakup of a conducting drop in a uniform electric field." Journal of Fluid Mechanics 754 (August 11, 2014): 550–89. http://dx.doi.org/10.1017/jfm.2014.402.

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AbstractA conducting drop suspended in a viscous dielectric and subjected to a uniform DC electric field deforms to a steady-state shape when the electric stress and the viscous stress balance. Beyond a critical electric capillary number $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}\mathit{Ca}$, which is the ratio of the electric to the capillary stress, a drop undergoes breakup. Although the steady-state deformation is indepen

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Shuaib, Abdulla, and Lokesh Singh. "Power and Stress Analysis of a Wind Turbine Blade under Various Wind Conditions." Key Engineering Materials 1008 (March 10, 2025): 93–104. https://doi.org/10.4028/p-likn6k.

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Wind Turbine Blade plays a significant role in the efficiency and durability of the wind turbine. As such it is important to identify different ways how the blade performance can be improved. One of the key variables that affects the blade performance is the stress the blade undergoes over time. This paper describes the stress characteristics of a Horizontal Axis Wind Turbine Blade subject to Aerodynamic Forces under normal operating conditions. The stress and deflection that the blade undergoes when subject to rated wind loads are analysed. The simulation results show that most of the stress

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Zgajnar, Nadia R., Cristina Daneri-Becerra, Ana Cauerhff, and Mario D. Galigniana. "The Scaffold Immunophilin FKBP51 Is a Phosphoprotein That Undergoes Dynamic Mitochondrial-Nuclear Shuttling." Cells 11, no. 23 (2022): 3771. http://dx.doi.org/10.3390/cells11233771.

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The immunophilin FKBP51 forms heterocomplexes with molecular chaperones, protein-kinases, protein-phosphatases, autophagy-related factors, and transcription factors. Like most scaffold proteins, FKBP51 can use a simple tethering mechanism to favor the efficiency of interactions with partner molecules, but it can also exert more complex allosteric controls over client factors, the immunophilin itself being a putative regulation target. One of the simplest strategies for regulating pathways and subcellular localization of proteins is phosphorylation. In this study, it is shown that scaffold immu

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Son, Kiho, Mike Small, Roma Sehmi, and Luke Janssen. "The eosinophil actin cytoskeleton undergoes rapid rearrangement in response to fluid shear stress." Journal of Leukocyte Biology 108, no. 1 (2020): 129–37. http://dx.doi.org/10.1002/jlb.1ma0320-349rr.

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Das, Rajdeep, and Oishee Chakrabarti. "Mitochondrial hyperfusion: a friend or a foe." Biochemical Society Transactions 48, no. 2 (2020): 631–44. http://dx.doi.org/10.1042/bst20190987.

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The cellular mitochondrial population undergoes repeated cycles of fission and fusion to maintain its integrity, as well as overall cellular homeostasis. While equilibrium usually exists between the fission–fusion dynamics, their rates are influenced by organellar and cellular metabolic and pathogenic conditions. Under conditions of cellular stress, there is a disruption of this fission and fusion balance and mitochondria undergo either increased fusion, forming a hyperfused meshwork or excessive fission to counteract stress and remove damaged mitochondria via mitophagy. While some previous re

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7

Dr., V. Saravanan. "A Study on Impact of Work Stress on Entrepreneurs - "With Special Reference to Cottage Industries." International Journal of Trend in Scientific Research and Development 2, no. 3 (2018): 2472–75. https://doi.org/10.31142/ijtsrd12786.

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The new modernization world have been faced various kinds of problems especially business men Facing large level of problems through their work environment, around the world each and every day changes new technologies, new trend of life, new information etc. these factors creates heavy competitions among the business men, especially affects the new entrepreneurs, the new entrepreneurs having lots of dreams and expectations for their business field, however to day business field creates high level of depression and stress , due to various unanticipated problems issues and challenges. Dr. V. Sar

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Arkles, Barry, Kevin King, and Keith Pannell. "Hydroxymethylsilanetriol – A Simple Analog of Silicic Acid." Silicon 5, no. 3 (2013): 187–97. https://doi.org/10.1007/s12633-013-9146-2.

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Hydroxymethyltriethoxysilane and hydroxymethyltrimethoxysilane, precursors by hydrolysis to a simple analog of silicic acid, hydroxymethylsilanetriol, were prepared. Hydroxymethyltrialkoxysilanes undergo condensation to form silmethyleneoxide oligomers and dimeric 2,2,5,5-tetraalkoxy-2,5-disila-1,4-dioxanes. Hydroxymethylsilanetriol undergoes condensation reactions similar to silicic acid and readily forms organosilicate structures by sol–gel processing techniques which may be converted at relatively low temperatures to silicon dioxide. Hydroxmethylsilanetriol derived gels were subject t

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9

Yin, Hua, Hong Zhang, and Rui Zhang. "Measurement and Simulation Analysis of Vertical Cross Longitudinal Settlement between Turning Shield and Foundation Pit." Advances in Civil Engineering 2021 (May 22, 2021): 1–14. http://dx.doi.org/10.1155/2021/6698268.

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Using numerical simulation technology, the dynamic three-dimensional model of the turning shield and the foundation pit under the condition of vertical intersection is established. The disturbance law of the longitudinal settlement of the foundation pit under the condition of shield construction is studied, and the stress path in the soil is analyzed. The results show that with the gradual advance of the turning shield construction, the settlement mode of the foundation pit changes with the shield construction. During the construction of the turning shield, when the tunnel face is located in f

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10

Bin Yusof, Mustafa, and Mohammad Amirul Affiz Bin Afripin. "Effect of Beam Profile Size on Bus Superstructure Strength Having Rollover Crash." Applied Mechanics and Materials 372 (August 2013): 620–29. http://dx.doi.org/10.4028/www.scientific.net/amm.372.620.

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This paper deals with structural analysis of bus superstructure undergoes rollover event. Bus superstructure with varying beam profile size will undergo rollover simulations analysis. The purpose of this work is to analyze structural response of bus superstructure in terms of deformation, stress and strain under several loadings and constraining conditions. These rollover simulations were run according to United Nation Economic Commission of Europe Regulation 66 (UNECE R66). Validation procedure using simple box modeled undergoes rollover have been done to ensure the results are synchronized w

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Leza, Juan. "Editorial [Hot Topic: How Brain Faces Stressors, Regulates Stress Response and Undergoes Stress Consequences (Guest Editor: Juan C. Leza)]." CNS & Neurological Disorders - Drug Targets 5, no. 5 (2006): 481–83. http://dx.doi.org/10.2174/187152706778559291.

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12

Verma, Vishnu, A. K. Ghosh, and H. S. Kushwaha. "Temperature Distribution and Thermal Stress Analysis of Ball-Tank Subjected to Solar Radiation." Journal of Pressure Vessel Technology 127, no. 2 (2005): 119–22. http://dx.doi.org/10.1115/1.1858920.

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The ball tank of the research reactor CIRUS is exposed to solar radiation. The ambient temperature undergoes seasonal and diurnal variation. The resulting thermal stress could be significant for the large structure. The temperature distribution has been obtained by the finite element method. The paper presents temperature distribution and the resulting thermal stress.

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13

Locke, Marius, and Earl G. Noble. "Stress Proteins: The Exercise Response." Canadian Journal of Applied Physiology 20, no. 2 (1995): 155–67. http://dx.doi.org/10.1139/h95-011.

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A class of proteins that undergoes preferential synthesis following a variety of stressors has been demonstrated to carry out important cellular functions under both stressed and nonstressed conditions. These so-called heat shock (HSP) or stress (SP) proteins have been termed "molecular chaperones" and play important roles in cellular transportation, assembly/degradation, and cell survival. This review provides a basic introduction to the function and regulation of these proteins. Emphasis is placed on members of the HSP 70 family of proteins (especially HSP 72) and their role in cellular prot

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Theuss, H., K. Elian, M. Fink, et al. "Mechanical Stress Impact of Assembly Processes onto a Stress-sensitive Testchip." International Symposium on Microelectronics 2011, no. 1 (2011): 000619–26. http://dx.doi.org/10.4071/isom-2011-wa5-paper3.

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A semiconductor die typically undergoes a variety of assembly processes, each of them influencing the mechanical stress environment of the chip. We report on a stress-sensitive testchip and its application to measure and characterize the respective stress distributions across the die. Particularly in the field of MEMS and sensor devices, even low stresses might deteriorate the electrical performance of a device significantly, while higher stress levels may even cause cracks and irreversible damage. This is why the present methodology has a high potential to develop into a useful tool in the fi

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Sun, Lihua, Rongxuan Zhou, Guiqin Li, Jianing Li, and Peter Mitrouchev. "Simulation Research on Residual Stress of Swage Autofrettage-processed High-Pressure Cylinder." Journal of Physics: Conference Series 2587, no. 1 (2023): 012088. http://dx.doi.org/10.1088/1742-6596/2587/1/012088.

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Abstract The vital component of the high-pressure pump is the high-pressure cylinder, which undergoes pulsating cyclic loads during operation. This exposure can lead to fatigue cracking and limit the pump’s overall performance. To address this issue, a swage autofrettage treatment method for the high-pressure cylinder is proposed based on the principles of autofrettage technology. The structure parameters of the mandrel are designed to optimize its role in the treatment process. Subsequently, a swage autofrettage simulation model is established, considering the Bauschinger effect to analyze th

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Stauffer, Bobbiejane, and Ted Powers. "Target of rapamycin signaling mediates vacuolar fission caused by endoplasmic reticulum stress in Saccharomyces cerevisiae." Molecular Biology of the Cell 26, no. 25 (2015): 4618–30. http://dx.doi.org/10.1091/mbc.e15-06-0344.

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The yeast vacuole is equivalent to the mammalian lysosome and, in response to diverse physiological and environmental stimuli, undergoes alterations both in size and number. Here we demonstrate that vacuoles fragment in response to stress within the endoplasmic reticulum (ER) caused by chemical or genetic perturbations. We establish that this response does not involve known signaling pathways linked previously to ER stress but instead requires the rapamycin-sensitive TOR Complex 1 (TORC1), a master regulator of cell growth, together with its downstream effectors, Tap42/Sit4 and Sch9. To identi

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Zhou, Haoyang, Qinxiang Xia, Chengxiu Quan, and Gangfeng Xiao. "Research on the deformation characteristics of small module tooth during current-assisted splitting spinning of small module tooth-shaped part." MATEC Web of Conferences 401 (2024): 04006. http://dx.doi.org/10.1051/matecconf/202440104006.

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Aiming at the problems such as low material utilization, poor strength and toughness of workpiece during manufacturing of small module tooth-shaped parts (SMTSPs) by traditional gear hobbing and shaping method, a current-assisted splitting spinning forming (CASSF) method was proposed to form SMTSPs with high performance requirements. A coupled electrical-thermal-mechanical finite element (FE) model was established based on the ABAQUS software, and the distribution of equivalent stress and equivalent strain, and deformation characteristics of small module tooth were investigated. The results sh

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18

Kaur, Navpreet, and Pramod Kaitheri Kandoth. "Tomato bZIP60 mRNA undergoes splicing in endoplasmic reticulum stress and in response to environmental stresses." Plant Physiology and Biochemistry 160 (March 2021): 397–403. http://dx.doi.org/10.1016/j.plaphy.2021.01.033.

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Kaur, Amandeep, Mohammad A. Haghighatbin, Conor F. Hogan, and Elizabeth J. New. "A FRET-based ratiometric redox probe for detecting oxidative stress by confocal microscopy, FLIM and flow cytometry." Chemical Communications 51, no. 52 (2015): 10510–13. http://dx.doi.org/10.1039/c5cc03394b.

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A FRET-based, ratiometric redox probe undergoes a fluorescence colour change upon reduction, and can be used to study cellular oxidative capacity using confocal microscopy, fluorescence lifetime imaging and flow cytometry.

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20

Adrian, D. W., and A. J. Giacomin. "The Transition to Quasi-Periodicity for Molten Plastics in Large Amplitude Oscillatory Shear." Journal of Engineering Materials and Technology 116, no. 4 (1994): 446–50. http://dx.doi.org/10.1115/1.2904311.

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Large amplitude oscillatory shear (LAOS) experiments on three grades of LLDPE including one commercial film blowing resin showed an interesting transition in the shear stress response to LAOS. The shear stress response is initially a nonsinusoidal standing wave which then undergoes a transition to quasi-periodicity. Many line-broadened odd and even harmonics were found in the shear stress amplitude spectra of the quasi-periodic responses. The transition time depends on shear strain amplitude and frequency, but it did not correlate with the weight average molecular weight of the LLDPE’s.

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Santos, Ronaldo Silva, Gabriel Martins-Silva, Adrián Adolfo Álvarez Padilla, et al. "Transcriptional and Post-Translational Roles of Calcineurin in Cationic Stress and Glycerol Biosynthesis in Cryptococcus neoformans." Journal of Fungi 10, no. 8 (2024): 531. http://dx.doi.org/10.3390/jof10080531.

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Stress management is an adaptive advantage for survival in adverse environments. Pathogens face this challenge during host colonization, requiring an appropriate stress response to establish infection. The fungal pathogen Cryptococcus neoformans undergoes thermal, oxidative, and osmotic stresses in the environment and animal host. Signaling systems controlled by Ras1, Hog1, and calcineurin respond to high temperatures and osmotic stress. Cationic stress caused by Na+, K+, and Li+ can be overcome with glycerol, the preferred osmolyte. Deleting the glycerol phosphate phosphatase gene (GPP2) prev

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22

Li, Yan Ru, Wan Shan Chen, Zhen Hai Wang, and Hai Bo Jiang. "Calculation of Stretch Stress of Double-Layer Plate Composites." Key Engineering Materials 861 (September 2020): 529–33. http://dx.doi.org/10.4028/www.scientific.net/kem.861.529.

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The stretch stress of each layer of laminate composite undergoes complex changes after being stretched, which significantly affects the stretch strength. In order to determine the magnitude of the change, the paper directly solved the stretch stress using the analytical method through simple assumptions, and obtained the analytical calculation formula. Studies on double-layer plates show that the magnitude of stretch stress is closely related to the elastic modulus, length and thickness dimensions of the plate layer, the shear modulus of the adhesive, the thickness of the adhesive layer, and t

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Xu, Yiwei, Chunjiang Zhao, Chen Wang, et al. "Compression–Shear Specimen Stress-State Response and Distribution Characteristics with Wide Stress Triaxiality." Materials 17, no. 6 (2024): 1424. http://dx.doi.org/10.3390/ma17061424.

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Conventional methods for studying the plastic behavior of materials involve uniaxial tension and uniaxial compression. However, in the metal rolling process, the deformation zone undergoes a complex loading of multidirectional compression and shear. Characterizing the corresponding plastic evolution process online poses challenges, and the existing specimen structures struggle to accurately replicate the deformation-induced loading characteristics. In this study, we aimed to design a compression–shear composite loading specimen that closely mimics the actual processing conditions. The goal was

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Ciornei, M., I. D. Savu, and S. V. Savu. "Metal Alloys for Filaments in 3D Fusion Filament Modelling Printing Process." Annals of Dunarea de Jos University of Galati Fascicle XII Welding Equipment and Technology 31 (December 28, 2020): 65–70. http://dx.doi.org/10.35219/awet.2020.10.

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The paper presents experimental research regarding the application of specific low melting metals in the FDM process. Previous trends in the transfer of the filament from the spool to the hot-end showed that the filament undergoes specific mechanical stress during the transfer. To achieve an appropriate transfer the filament should prove stiffness and resistance to the mechanical actions of the transfer wheels. At the same time, the entrance to the hot-end creates specific resistance to the movement of the filament, and the filament undergoes important deformations. The experimental research u

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Felippa, Carlos A., and Eugenio On˜ate. "Volumetric Constraint Models for Anisotropic Elastic Solids." Journal of Applied Mechanics 71, no. 5 (2004): 731–34. http://dx.doi.org/10.1115/1.1748318.

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We study three “incompressibility flavors” of linearly elastic anisotropic solids that exhibit volumetric constraints: isochoric, hydroisochoric, and rigidtropic. An isochoric material deforms without volume change under any stress system. An hydroisochoric material does so under hydrostatic stress. A rigidtropic material undergoes zero deformations under a certain stress pattern. Whereas the three models coalesce for isotropic materials, important differences appear for anisotropic behavior. We find that isochoric and hydroisochoric models under certain conditions may be hampered by unstable

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Khan, Elaine M., Jill M. Heidinger, Michal Levy, Michael P. Lisanti, Tommer Ravid, and Tzipora Goldkorn. "Epidermal Growth Factor Receptor Exposed to Oxidative Stress Undergoes Src- and Caveolin-1-dependent Perinuclear Trafficking." Journal of Biological Chemistry 281, no. 20 (2006): 14486–93. http://dx.doi.org/10.1074/jbc.m509332200.

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Redmond, Sarah, Erick Biggs, Kasey Blevins, et al. "IgA You Assay? The Correlation between Sleep and Stress." Journal of Immunology 198, no. 1_Supplement (2017): 210.14. http://dx.doi.org/10.4049/jimmunol.198.supp.210.14.

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Abstract The most well known fact about sleep is that humans need it - while we are asleep our metabolic processes slow down and during long periods of sleep our bodies repair the damage that the stress our bodies have undergone throughout the day. Throughout the day our bodies are bombarded by signals from the environment, and undergoes biological changes in response to external and internal stimuli. Sleep is a period of time to restore the body to optimum condition to continue the process all over again the next day. The human body regulates stress by producing glucocorticoid steroid hormone

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Ribeiro, Maysa Ferreira Martins, Ana Luiza Lima Sousa, Luc Vandenberghe, and Celmo Celeno Porto. "Parental stress in mothers of children and adolescents with cerebral palsy." Revista Latino-Americana de Enfermagem 22, no. 3 (2014): 440–47. http://dx.doi.org/10.1590/0104-1169.3409.2435.

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OBJECTIVES: to evaluate parental stress of mothers of children and adolescents with cerebral palsy; to verify whether parental stress undergoes variations according to the level of motor compromise, the child's phase of life, and sociodemographic variables.METHOD: a cross-sectional, descriptive study, with 223 mothers of children and adolescents with cerebral palsy.RESULTS: 45.3% of the mothers presented high levels of stress; there were differences in stress between mothers of children with mild and severe motor impairment; mothers of older children were more stressed than mothers of younger

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Wang, Yongshuai, Haodong Wang, Xuanfu He, and Cunxian Wang. "Stress-strain Curve Correction Based on Finite Element Method." Journal of Physics: Conference Series 2535, no. 1 (2023): 012007. http://dx.doi.org/10.1088/1742-6596/2535/1/012007.

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Abstract Necking is a very common phenomenon in uniaxial tensile experiments. It is particularly prominent in materials with high-stress levels. It can be considered a deformation destabilization phenomenon or a localized concentration of deformation. The occurrence of this phenomenon can lead to the failure of the stress-strain curve of the material. Therefore, this paper will examine the problem of stress-strain curve correction in uniaxial tension for materials with high levels of yield stress. Due to the high-stress levels in this class of materials, the material quickly undergoes necking

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Romero Heredia, Nathaly Alejandra, and Andrés Joaquín Guarnizo Chávez. "Psychocutaneous disorder due to university stress-A case study." Journal of Neurology & Stroke 12, no. 1 (2022): 5–7. http://dx.doi.org/10.15406/jnsk.2022.12.00488.

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Psychocutaneous disorders, or allergies exacerbated by psychological factors in adults, are a group of dermatological diseases, where an underlying condition such as atopic dermatitis is triggered by psychological stressors, and whose diagnosis is made by clinical, questioning, and ruling out others most frequent skin pathologies. It is closely linked to certain triggering psychological factors, which can be stress or anxiety. The present article includes a case study of an undergraduate patient, with the classic symptoms of a skin allergy. However, her case undergoes diagnostic trials without

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Ullrich, Susanne, Michael Kube, Sabrina Schübbe, Richard Reinhardt, and Dirk Schüler. "A Hypervariable 130-Kilobase Genomic Region of Magnetospirillum gryphiswaldense Comprises a Magnetosome Island Which Undergoes Frequent Rearrangements during Stationary Growth." Journal of Bacteriology 187, no. 21 (2005): 7176–84. http://dx.doi.org/10.1128/jb.187.21.7176-7184.2005.

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ABSTRACT Genes involved in magnetite biomineralization are clustered in the genome of the magnetotactic bacterium Magnetospirillum gryphiswaldense. We analyzed a 482-kb genomic fragment, in which we identified an approximately 130-kb region representing a putative genomic “magnetosome island” (MAI). In addition to all known magnetosome genes, the MAI contains genes putatively involved in magnetosome biomineralization and numerous genes with unknown functions, as well as pseudogenes, and it is particularly rich in insertion elements. Substantial sequence polymorphism of clones from different su

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Barber, Ross W., Molly E. McFadden, Xiaoran Hu, and Maxwell J. Robb. "Mechanochemically Gated Photoswitching: Expanding the Scope of Polymer Mechanochromism." Synlett 30, no. 15 (2019): 1725–32. http://dx.doi.org/10.1055/s-0037-1611858.

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Mechanophores are molecules that undergo productive, covalent chemical transformations in response to mechanical force. Over the last decade, a variety of mechanochromic mechanophores have been developed that enable the direct visualization of stress in polymers and polymeric materials through changes in color and chemiluminescence. The recent introduction of mechanochemically gated photoswitching extends the repertoire of polymer mechanochromism by decoupling the mechanical activation from the visible response, enabling the mechanical history of polymers to be recorded and read on-demand usin

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Zhao, Huihe, Hongxiang Jiang, and Zijian Wu. "Study on the Mechanism of Mechanical Impact on Heterogeneous Plate Rock." Advances in Computer and Materials Scienc Research 3, no. 1 (2025): 51. https://doi.org/10.70114/acmsr.2025.3.1.p51.

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The numerical model for mechanical impact breaking of heterogeneous rocks is established by LS DYNA through secondary development, and the RHT (Riedel Hiermaier Thomas) model is used to characterize the mechanical properties of rocks. The research results indicate that during the process of mechanical impact rock breaking, the rock undergoes multiple changes in compressive-tensile stress, which exacerbates the damage and crack propagation of the rock. There is a phenomenon of interlayer distribution and boundary layer ambiguity in the propagation of stress waves inside heterogeneous rocks

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Stanculescu, Andreea D., Dominic G. Iliescu, Octavian Dragoescu, et al. "Postoperative delirium incidence and oxidative stress in laparoscopic surgery." Romanian Journal of Psychiatry and Psychotherapy 19, no. 2 (2017): 69–73. http://dx.doi.org/10.37897/rjpp.2017.2.7.

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Postoperative delirium is a common complication of all types of surgery, especially in elderly patients (2). Overproduction of free oxygen radicals and decrease of organism defense mechanisms is believed to be involved in multiorgan failure, especially in the brain (4). It is important to determinate the susceptibility, incidence and preventive measures for postoperative delirium (8). Our objective was to identify an oxidative stress indicator that predicts the appearance of postoperative delirium in patients that undergoes laparoscopic renal or gynecological surgery for malignant diseases and

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Mulford, K. E., and J. S. Fassler. "Association of the Skn7 and Yap1 Transcription Factors in the Saccharomyces cerevisiae Oxidative Stress Response." Eukaryotic Cell 10, no. 6 (2011): 761–69. http://dx.doi.org/10.1128/ec.00328-10.

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ABSTRACT Saccharomyces cerevisiae Skn7p is a stress response transcription factor that undergoes aspartyl phosphorylation by the Sln1p histidine kinase. Aspartyl phosphorylation of Skn7p is required for activation of genes required in response to wall stress, but Skn7p also activates oxidative stress response genes in an aspartyl phosphorylation-independent manner. The presence of binding sites for the Yap1p and Skn7p transcription factors in oxidative stress response promoters and the oxidative stress-sensitive phenotypes of SKN7 and YAP1 mutants suggest that these two factors work together.

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Heyer, Babette S., Alasdair MacAuley, Ole Behrendtsen, and Zena Werb. "Hypersensitivity to DNA damage leads to increased apoptosis during early mouse development." Genes & Development 14, no. 16 (2000): 2072–84. http://dx.doi.org/10.1101/gad.14.16.2072.

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Gastrulation in mice is associated with the start of extreme proliferation and differentiation. The potential cost to the embryo of a very rapid proliferation rate is a high production of damaged cells. We demonstrate a novel surveillance mechanism for the elimination of cells damaged by ionizing radiation during mouse gastrulation. During this restricted developmental window, the embryo becomes hypersensitive to DNA damage induced by low dose irradiation (<0.5 Gy) and undergoes apoptosis without cell cycle arrest. Intriguingly, embryonic cells, including germ cell progenitors, but not extr

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Cook, S. J., K. Balmanno, A. Garner, T. Millar, C. Taverner, and D. Todd. "Regulation of cell cycle re-entry by growth, survival and stress signalling pathways." Biochemical Society Transactions 28, no. 2 (2000): 233–40. http://dx.doi.org/10.1042/bst0280233.

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The mitogen-activated and stress-activated protein kinases transduce signals from plasma membrane signalling machinery into the nucleus to modulate gene expression. By regulating the genomic response to environmental cues (growth factors, stresses) these pathways determine whether a cell re-enters the cell cycle, undergoes cell cycle arrest, senescence or apoptosis. We are particularly interested in how these pathways integrate with each other, and interact with the cell cycle machinery to achieve these discrete biological responses.

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Murdza, Andrii, Erland M. Schulson, and Carl E. Renshaw. "Strengthening of columnar-grained freshwater ice through cyclic flexural loading." Journal of Glaciology 66, no. 258 (2020): 556–66. http://dx.doi.org/10.1017/jog.2020.31.

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AbstractSystematic experiments reveal that the flexural strength of freshwater S2 columnar-grained ice loaded normal to the columns increases upon cyclic loading. Specifically, over the range of stress amplitudes 0.1–2.6 MPa the flexural strength increases linearly with increasing stress amplitude. The experiments were conducted upon both reversed and non-reversed cyclic loading over ranges of frequencies from 0.03 to 2 Hz and temperatures from −25 to −3°C. Strengthening can also be imparted through bending-induced creep. The fundamental requirement for strengthening is that the surface that u

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Hadari, Yaron R., Hans U. Haring, and Yehiel Zick. "p75, a Member of the Heat Shock Protein Family, Undergoes Tyrosine Phosphorylation in Response to Oxidative Stress." Journal of Biological Chemistry 272, no. 1 (1997): 657–62. http://dx.doi.org/10.1074/jbc.272.1.657.

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Wang, Kezhong, Yu Xiong, Sheng Li, Xin Zhou, and Zhikuan Li. "Deformation Characteristics Analysis of Temporary Support in Unsymmetrical Loading Tunnel Excavation under Composite Support." Symmetry 15, no. 4 (2023): 830. http://dx.doi.org/10.3390/sym15040830.

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Based on practical engineering, considering the characteristics of unsymmetrical loading, shallow burying, and weak surrounding rock of the tunnel, MIDAS finite element software is adopted to analyze the influence effect and deformation characteristics of a temporary steel support when the tunnel is excavated by a two-step center diaphragm method (CDM). The simulation results are compared with the field monitoring results. It can be seen that: (1) Affected by the unsymmetrical loading, the settlement of the right spandrel of the tunnel is obvious. The existence of a temporary steel support red

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Chen, X., and John W. Hutchinson. "Herringbone Buckling Patterns of Compressed Thin Films on Compliant Substrates." Journal of Applied Mechanics 71, no. 5 (2004): 597–603. http://dx.doi.org/10.1115/1.1756141.

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A thin metal film vapor deposited on thick elastomer substrate develops an equi-biaxial compressive stress state when the system is cooled due to the large thermal expansion mismatch between the elastomer and the metal. At a critical stress, the film undergoes buckling into a family of modes with short wavelengths characteristic of a thin plate on a compliant elastic foundation. As the system is further cooled, a highly ordered herringbone pattern has been observed to develop. Here it is shown that the herringbone mode constitutes a minimum energy configuration among a limited set of competing

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Cao, Wei, Mingyi Zhang, Nan Wu, et al. "Comparative Transcriptome Analysis Elucidates the Desiccation Stress Adaptation in Sargassum muticum." Genes 16, no. 5 (2025): 587. https://doi.org/10.3390/genes16050587.

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Background/Objectives: Desiccation profoundly influences the distribution and abundance of intertidal seaweeds, necessitating robust molecular adaptations. Sargassum muticum is a brown seaweed inhabiting intertidal rocky substrates. During low tides, this species undergoes periodic aerial exposure. Such environmental conditions necessitate robust physiological mechanisms to mitigate desiccation stress. Yet, the molecular basis of this adaptation remains poorly understood. Methods: To investigate desiccation-responsive genes and elucidate the underlying mechanisms of adaptation, we exposed S. m

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Mina, John G., Anutthaman Parthasarathy, Exequiel O. Porta, Paul W. Denny, and Karunakaran Kalesh. "BONCAT-iTRAQ Labelling Reveals Molecular Markers of Adaptive Responses in Toxoplasma gondii to Pyrimethamine Treatment." Pathogens 13, no. 10 (2024): 879. http://dx.doi.org/10.3390/pathogens13100879.

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We employed a BONCAT-iTRAQ labelling approach to investigate newly synthesised proteins (NSPs) in Toxoplasma gondii subjected to varying concentrations of the antifolate drug pyrimethamine. Our results reveal that numerous NSPs exhibited altered expression levels in response to the drug, with significant upregulation observed at higher concentrations. Key proteins involved in protein synthesis, stress responses, energy metabolism, and cytoskeletal dynamics were identified, indicating that T. gondii undergoes complex adaptive responses to pyrimethamine treatment. While some of the identified pa

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Liu, Jian Xiong, Hui Mian Li, Jun Hong Li, Zheng Yu Wu, and Zhao Lin Zhan. "Research for Transverse Tension Distribution on Steel Strip in Continuous-Annealing Furnace Based on ANSYS." Advanced Materials Research 139-141 (October 2010): 210–13. http://dx.doi.org/10.4028/www.scientific.net/amr.139-141.210.

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The cold rolled strip undergoes great transforming of micro-organization and change in properties in continuous annealing furnace. At the same time, it is acted upon by all kinds of forces, such as tensile and compressive stresses, bending stress, thermal stress. and thus it would affect stability of the steel strip. The finite element model of steel strip and guide rollers are established, and the ANSYS software is used to study the effects on transverse stress distribution under different strip shapes that contains center buckle, double edge wave, compound buckle, quarter buckle and quality

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LUO, Shengzhan, and Amy S. LEE. "Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation." Biochemical Journal 366, no. 3 (2002): 787–95. http://dx.doi.org/10.1042/bj20011802.

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Malfolded protein formation and perturbance of calcium homoeostasis results in the induction of the endoplasmic reticulum (ER) chaperone protein, namely the 78kDa glucose-regulated protein (GRP78)/immunoglobulin heavy-chain binding protein. Various ER stress inducers can activate grp78, but signal transduction mechanisms are not well understood. We report in the present study that the induction of endogenous grp78 mRNA by the amino acid analogue azetidine (AzC) requires the integrity of a signal transduction pathway mediated by p38 mitogen-activated protein kinase (p38 MAPK). In contrast, indu

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Kopecká, Romana, Michaela Kameniarová, Martin Černý, Břetislav Brzobohatý, and Jan Novák. "Abiotic Stress in Crop Production." International Journal of Molecular Sciences 24, no. 7 (2023): 6603. http://dx.doi.org/10.3390/ijms24076603.

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The vast majority of agricultural land undergoes abiotic stress that can significantly reduce agricultural yields. Understanding the mechanisms of plant defenses against stresses and putting this knowledge into practice is, therefore, an integral part of sustainable agriculture. In this review, we focus on current findings in plant resistance to four cardinal abiotic stressors—drought, heat, salinity, and low temperatures. Apart from the description of the newly discovered mechanisms of signaling and resistance to abiotic stress, this review also focuses on the importance of primary and second

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Rahmad, Muhamad Nur, Sutarman Sutarman, Maria Wisnu Kanita, and Yola Kinanthi Wening Utami. "The Relationship Between The Hemodialysis Span and The Stress Level and Sleep Quality of Chronic Kidney Failure Patients In Hemodialysis Room At Tk. III Slamet Riyadi Hospital Surakarta." Journal of Midwifery and Nursing 6, no. 2 (2024): 591–96. http://dx.doi.org/10.35335/jmn.v6i2.4322.

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Hemodialysis will affect stress levels and sleep quality in chronic kidney failure patients. The longer a patient with chronic kidney failure undergoes hemodialysis therapy, the patient's stress level and sleep quality will worsen. The study aimed to analyze the relationship between the term hemodialysis and the stress level and sleep quality of chronic kidney failure patients at Tk.III Slamet Riyadi Hospital, Surakarta. The research adopted a quantitative descriptive analytical design with a cross-sectional approach. The sampling technique used total sampling with 57 respondents. Data collect

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Zhang, Baohong, Fei Xie, Aziz Aziz, et al. "Heat Shock Protein 27 Phosphorylation Regulates Tumor Cell Migration under Shear Stress." Biomolecules 9, no. 2 (2019): 50. http://dx.doi.org/10.3390/biom9020050.

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Heat shock protein 27 (HSP27) is a multifunctional protein that undergoes significant changes in its expression and phosphorylation in response to shear stress stimuli, suggesting that it may be involved in mechanotransduction. However, the mechanism of HSP27 affecting tumor cell migration under shear stress is still not clear. In this study, HSP27-enhanced cyan fluorescent protein (ECFP) and HSP27-Ypet plasmids are constructed to visualize the self-polymerization of HSP27 in living cells based on fluorescence resonance energy transfer technology. The results show that shear stress induces pol

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Liu, Zhoucheng, Jinsheng Ji, Qiang Wang, Xiaohu Guan, Leilei Wang, and Xiaohong Zhan. "Effect of Scanning Strategy on Microstructure Evolution and Stress Control in Laser Cladding Repair of Ti6Al4V Alloy." Metals 14, no. 7 (2024): 805. http://dx.doi.org/10.3390/met14070805.

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Laser cladding provides a cost-effective and high-quality solution for repairing aircraft engines. A finite element model was developed in this study to simulate and analyze the stress distribution during the cladding of a complex curved groove structure made of Ti6Al4V. The mechanism underlying the microstructure at the interface was revealed. The stress concentration locations in the curved groove structure are located at the intersection of the cladding layer and sidewall, as well as at both ends of the cladding layer and the groove bottom. By applying reverse swing scanning, a more consist

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Nakai, Masaaki, Mitsuo Niinomi, Xiao Li Zhao, and Xing Feng Zhao. "Young’s Modulus Changeable Titanium Alloys for Orthopaedic Applications." Materials Science Forum 706-709 (January 2012): 557–60. http://dx.doi.org/10.4028/www.scientific.net/msf.706-709.557.

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A novel biomedical titanium alloy with the ability to undergo self-adjustment in its Young’s modulus was developed. In spinal fixation devices, the Young’s modulus of the metallic implant rod should be sufficiently high to suppress springback for the surgeon, but should also be sufficiently low to prevent stress shielding for the patient. Therefore, deformation-induced ω phase transformation was introduced into β-type titanium alloys so that the Young’s modulus of only the deformed part would increase during operation, while that of the non-deformed part would remain low. The increase in the Y

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