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Journal articles on the topic 'Uricosuria'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Turaeva, Nazira Yuldashevna, and Feruza Khamidovna Mamatkulova. "PREMORBIDE FEATURES OF INTERSTITIAL NEPHRITIS CURRENT IN CHILDREN WITH PURINE DYSMETABOLISM (CLINICAL-LABORATORY ASPECTS)." Multidisciplinary Journal of Science and Technology 4, no. 6 (2024): 201–5. https://doi.org/10.5281/zenodo.11652270.

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Purpose of the study. To study the clinical-laboratory features of the current interstitial nephritis in children developed against the background of hyperuricosuria and hyperuricosuria. Materials and methods. Examined 82 patients with a diagnosis interstitial nephritis of dysmetabolic genesis against uricosuria background of more than 1mg of uric acids per 1ml of urine. The metabolic status of patients was evaluated according to a special program, including genealogical analysis, screening tests and quantitative biochemicall Studies. Urichemy was defined as the main biochemical marker (>32

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2

Abraham, Paul A., Charles E. Halstenson, John A. Opsahl, Gary R. Matzke, and William F. Keane. "Suprofen-Induced Uricosuria." American Journal of Nephrology 8, no. 2 (1988): 90–95. http://dx.doi.org/10.1159/000167564.

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3

Gresser, U., U. Kronawitter, O. Adjan, and N. Zöllner. "Rapid onset of uricosuria after oral administration of irtemazole, an uricosuric substance." Klinische Wochenschrift 67, no. 20 (1989): 1058–60. http://dx.doi.org/10.1007/bf01727008.

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4

Golovanov, S. A., M. Yu Prosyannikov, A. V. Sivkov, N. V. Anokhin, D. A. Voytko, and V. V. Drozhzheva. "Metabolic risk factors and urinary stones formation. VII: Uricosuria lithogenic features in men and women." Experimental and Сlinical Urology 16, no. 3 (2023): 154–64. http://dx.doi.org/10.29188/2222-8543-2023-16-3-154-164.

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Introduction. Hyperuricosuria usually considered as the main metabolic factor in the formation of uric acid stones, but this issue remains unclear. Gender differences in the prevalence of urolithiasis (UL) indicate the need for a more detailed study of the lithogenic properties of uricosuria and its role in the development of various metabolic types of UL. In this study, was investigated the effect of varying degrees of uricosuria in men and women with UL on metabolic parameters and the frequency of detection of urinary stones of different chemical composition. Materials and methods. A total o

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P., Randrianavony, Reboza A.M., Quansah N., and Randimbivololona F. "Hypouricemic Activity of Pentopetia Androsaemifolia Decne. (Apocynaceae) Hydro Alcoholic Extract in Mice." European Scientific Journal, ESJ 13, no. 36 (2017): 340. http://dx.doi.org/10.19044/esj.2017.v13n36p340.

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The aim of this work was to investigate the uricemic and uricosuric activity of the hydro alcoholic extract of Pentopetia androsaemifolia in experimentally induced hyperuricemic mice. Hyperuricemia was induced in the mice by intraperitoneal injection of potassium oxonate. Oral administration of the extract at doses 50 to 200 mg/kg reduce hyperuricemia from 218.78 ± 7.50 to 72.29 ± 16.88 mg/l (P< 0. 05). The same doses of 50 to 200 mg/kg of the extract also reduce uricosuria from 125.4 ± 4.4 to 70 ± 12.6 mg/l (p< 0.05). A direct correlation exists between plasma uric acid concentration an

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6

Bombushkar, Igor. "Metabolic accompaniments of variants of uric acid exchange." Journal of Education, Health and Sport 12, no. 12 (2022): 373–90. http://dx.doi.org/10.12775/jehs.2022.12.12.054.

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Background. During the implementation of the project "Physiological activity of uric acid", our group discovered four variants of the combination of levels of uricemia and uricosuria in patients with chronic pyelonephritis in the remission phase, which are accompanied by characteristic constellations of parameters of the autonomic nervous, endocrine, and immune systems, the levels of which correlate with uricemia and/or uricosuria. The aim of this study is to clarify the relationship between parameters of exchange of uric acid and other metabolites. Materials and methods. Under an observations

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Zapf, Ava M., and Owen M. Woodward. "SGLT2 Inhibitors and Uric Acid Homeostasis." Gout, Urate, and Crystal Deposition Disease 2, no. 2 (2024): 157–72. http://dx.doi.org/10.3390/gucdd2020014.

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A relationship between metabolic disorders and hyperuricemia is well established. The nature of the relationship—risk factor, causal agent, or byproduct—remains unclear. Recent studies of sodium–glucose transporter 2 inhibitors (SGLT2i’s) have established that this pharmacological intervention is beneficial to patients with hyperglycemia and type 2 diabetes mellitus (T2D) and also against the common cardio and renal comorbidities associated with diabetes. Hyperuricemia, or high plasma uric acid levels, is one of the comorbidities mitigated with SGLT2i treatment, raising the potential for using

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8

Mukiy, Yu V., D. I. Bogomaz, and O. A. Pavlova. "Nephrolithiasis and uricosuria diagnostics in dogs." BIO Web of Conferences 66 (2023): 09004. http://dx.doi.org/10.1051/bioconf/20236609004.

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Nephrolithiasis and hyperuricosuria is a common pathology in dogs of various breeds. The problem of breeding lies in the fact that the diagnostic methods used: X-ray examination, determination of lipid composition in the blood and the urogenital microbiome, do not allow early diagnostics in young dogs before the onset of clinical changes, as well as to identify animals carrying mutant alleles of disease candidate genes. We have developed a test system for nephrolithiasis and uricosuria diagnostics in dogs, including primers and allele-selective probes. A control plasmid solution was used as a

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9

Bombushkar, Igor, Igor Popovych, and Walery Zukow. "Relationships between the parameters of uric acid exchange and electroencephalograms in humans." Journal of Education, Health and Sport 13, no. 3 (2023): 458–85. http://dx.doi.org/10.12775/jehs.2023.13.03.055.

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Background. During the implementation of the project "Physiological activity of uric acid", our group discovered four variants of the combination of levels of uricemia and uricosuria both in healthy rats and in people with chronic pyelonephritis and cholecystitis in the remission phase, which are accompanied by characteristic constellations of parameters of the autonomic nervous, endocrine, and immune systems, as well as the exchange of nitrogenous metabolites and electrolytes, the levels of which correlate with uricemia and/or uricosuria. The aim of this study is to clarify the relationship b

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Bombushkar, Igor, Anatoliy Gozhenko, Inna Korda, Nataliya Badiuk, Walery Zukow, and Igor Popovych. "Features of the exchange of electrolytes and nitrogenous metabolites under different options of uric acid exchange in healthy female rats." Journal of Education, Health and Sport 10, no. 4 (2020): 405–15. http://dx.doi.org/10.12775/jehs.2020.10.04.043.

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Background. We previously identified 4 variants-clusters of uricemia and uricosuria both in rats and in humans. It was shown that the clusters differ from each other in the constellation of immune, autonomic and endocrine parameters, which correlate with uricemia and uricosuria. The aim of this study was to identify the electrolytes and nitrogenous metabolites, the combination of which differentiates previously formed quantitative and qualitative variants of uric acid metabolism in rats. Materials and Methods. Experiment was performed on 60 healthy female Wistar rats 220-300 g. The plasma and

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Popovych, Igor, Igor Bombushkar, Xawery Żukow, and Halyna Kovalchuk. "Uric acid, neuroendocrine-immune complex and metabolism: relationships." Journal of Education, Health and Sport 36, no. 1 (2023): 135–59. http://dx.doi.org/10.12775/jehs.2023.36.01.013.

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Background. During the implementation of the project "Physiological activity of uric acid", our group discovered four variants of the combination of levels of uricemia and uricosuria in patients with chronic pyelonephritis in the remission phase, which are accompanied by characteristic constellations of parameters of the central and autonomic nervous, endocrine, and immune systems, as well as the exchange of nitrogenous metabolites and electrolytes, the levels of which correlate with uricemia and/or uricosuria. The aim of this study is to clarify the relationship between parameters of uric aci

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12

Shah, Palak A., and Gaurang B. Shah. "Uricosuric activity of Tinospora cordifolia." Bangladesh Journal of Pharmacology 10, no. 4 (2015): 884. http://dx.doi.org/10.3329/bjp.v10i4.25160.

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<p class="Abstract">Uricosuric activity of different extracts of <em>Tinospora cordifolia</em> was studied in hyperuricemia induced in albino Wistar rat using potassium oxonate. The uric acid level in serum and urine were measured. Uricosuric activity was also evaluated using phenol red dye excretion model. Phenol red levels were measured in blood. In potassium oxonate induced hyperuricemia, probenecid, aqueous, hydro-alcoholic, dichloromethane extract and galo satwa (starch of <em>T. cordifolia</em>) significantly lowered the serum uric acid levels. All the extra

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Popovych, Igor, Igor Bombushkar, Nataliya Badiuk, Inna Korda, Walery Zukow, and Anatoliy Gozhenko. "Features of the state of neuro-endocrine factors of adaptation under different options of uric acid metabolism in healthy female rats." Journal of Education, Health and Sport 10, no. 3 (2020): 352–62. http://dx.doi.org/10.12775/jehs.2020.10.03.038.

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Background. As part of the project "Physiological activity of uric acid", we previously identified 4 variants-clusters of uricemia and uricosuria both in rats and in humans. It was shown that the clusters differ from each other in the constellation of immunity parameters, which to one degree or another correlate with uricemia and uricosuria. The aim of this study was to identify autonomic and endocrine adaptogenic factors, the combination of which differentiates previously formed quantitative and qualitative variants of uric acid metabolism in rats. Materials and Methods. Experiment was perfor

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14

Jeevanandam, M., Y. C. Hsu, L. Ramias, and W. R. Schiller. "Mild orotic aciduria and uricosuria in severe trauma victims." American Journal of Clinical Nutrition 53, no. 5 (1991): 1242–48. http://dx.doi.org/10.1093/ajcn/53.5.1242.

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15

Bjornstad, Petter, Carlos Roncal, Tamara Milagres, et al. "Hyperfiltration and uricosuria in adolescents with type 1 diabetes." Pediatric Nephrology 31, no. 5 (2015): 787–93. http://dx.doi.org/10.1007/s00467-015-3299-8.

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16

Landau, D., D. Tovbin, and H. Shalev. "Pediatric urolithiasis in southern Israel: the role of uricosuria." Pediatric Nephrology 14, no. 12 (2000): 1105–10. http://dx.doi.org/10.1007/s004670000328.

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17

Addanki, Raja Narendra Divakar, and Anjali Srikanth Mannava. "Role of silica nanoparticles in pathogenesis of Mesoamerican nephropathy." International Journal of Research in Medical Sciences 11, no. 10 (2023): 3945–46. http://dx.doi.org/10.18203/2320-6012.ijrms20233068.

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The authors have done an excellent job in shedding light on Mesoamerican nephropathy (MeN), a lesser-known variant of chronic kidney disease that affects agricultural workers in rural areas especially regions with hot climates like Central America, etc. The inclusion of social factors in the pathogenesis and highlighting the risks posed by nephrotoxic drugs and heat stress leading to subclinical rhabdomyolysis and uricosuria are crucial contributions to the understanding of MeN.

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18

Bombushkar, Igor. "Features of the state of the neuroendocrine-immune complex and electrolyte-nitrogenous exchange under different variations of uric acid metabolism in female rats." Journal of Education, Health and Sport 10, no. 5 (2020): 410–21. http://dx.doi.org/10.12775/jehs.2020.10.05.044.

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Background. This article concludes the experimental part of the project "Physiological activity of uric acid". Our group previously identified 4 variants-clusters of uricemia and uricosuria both in rats and in humans. It was shown that the clusters differ from each other in the constellation of immune, autonomic and endocrine parameters as well as plasma and urine electrolytes and nitrogenous parameters, which to one degree or another correlate with uricemia and uricosuria. Because the autonomic, endocrine and immune parameters interact with each other within the neuro-endocrine-immune complex

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19

SUGINO, Haruko, and Hideyo SHIMADA. "Intravenous Infusion of Diltiazem Causes Uricosuria with Concomitant Hypouricemia in Rats." Biological & Pharmaceutical Bulletin 19, no. 4 (1996): 627–29. http://dx.doi.org/10.1248/bpb.19.627.

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20

Frajewicki, Victor, Daniel Kushnir, and Amnon Gil. "WCN24-1932 THE ASSOCIATION OF RENAL FUNCTION DETERIORATION WITH BASELINE URICOSURIA." Kidney International Reports 9, no. 4 (2024): S95. http://dx.doi.org/10.1016/j.ekir.2024.02.203.

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21

Roncal-Jimenez, Carlos A., Ramon García-Trabanino, Catharina Wesseling, and Richard J. Johnson. "Mesoamerican Nephropathy or Global Warming Nephropathy?" Blood Purification 41, no. 1-3 (2016): 135–38. http://dx.doi.org/10.1159/000441265.

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Background: An epidemic of chronic kidney disease (CKD) of unknown cause has emerged along the Pacific Coast of Central America. The disease primarily affects men working manually outdoors, and the major group affected is sugarcane workers. The disease presents with an asymptomatic rise in serum creatinine that progresses to end-stage renal disease over several years. Renal biopsies show chronic tubulointerstitial disease. While the cause remains unknown, recent studies suggest that it is driven by recurrent dehydration in the hot climate. Potential mechanisms include the development of hypero

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22

Bauzá, Jose Luis, Paula Calvó, Francesca Julià, et al. "Relationship between Urinary Parameters and Double-J Stent Encrustation." Journal of Clinical Medicine 12, no. 15 (2023): 5149. http://dx.doi.org/10.3390/jcm12155149.

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(1) Background: This study aimed to determine the relationship between metabolic urine conditions and the formation, severity, and composition of encrustations in ureteral stents. (2) Methods: Ninety stone-former patients requiring a double-J stent were prospectively enrolled. We collected 24 h metabolic urine samples and demographic data, including indwelling time and previous stone composition. The total deposit weight was obtained, and a macroscopic classification according to the degree of encrustation (null, low, moderate, and high) was created, allowing for intergroup comparisons. Stereo

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23

Lytvyn, Yuliya, Marko Škrtić, Gary K. Yang, Paul M. Yip, Bruce A. Perkins, and David Z. I. Cherney. "Glycosuria-mediated urinary uric acid excretion in patients with uncomplicated type 1 diabetes mellitus." American Journal of Physiology-Renal Physiology 308, no. 2 (2015): F77—F83. http://dx.doi.org/10.1152/ajprenal.00555.2014.

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Plasma uric acid (PUA) is associated with metabolic, cardiovascular, and renal abnormalities in patients with type 2 diabetes but is less well understood in type 1 diabetes (T1D). Our aim was to compare PUA levels and fractional uric acid excretion (FEUA) in patients with T1D vs. healthy controls (HC) during euglycemia and hyperglycemia. PUA, FEUA, blood pressure (BP), glomerular filtration rate (GFR-inulin), and effective renal plasma flow (ERPF-paraaminohippurate) were evaluated in patients with T1D ( n = 66) during clamped euglycemia (glucose 4–6 mmol/l) and hyperglycemia (9–11 mmol/l), and

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Quereda, C., L. Orte, J. Sabater, J. Navarro-Antolin, J. J. Villafruela, and J. Ortuño. "Urinary calcium excretion in treated and untreated essential hypertension." Journal of the American Society of Nephrology 7, no. 7 (1996): 1058–65. http://dx.doi.org/10.1681/asn.v771058.

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A high prevalence of hypercalciuria has been reported in patients with essential hypertension. Nevertheless, the clinical and therapeutic implications of this finding have scarcely been studied. This study was designed to determine the prevalence of hypercalciuria in an unselected population with essential hypertension and to analyze the relationship between the urinary calcium and the clinical and therapeutic status of these patients. This article presents a prospective study of 112 patients with essential hypertension and 49 healthy normotensive control subjects. Urinary excretion rates of c

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Gozhenko, Anatoliy I., Vadym S. Smagliy, Inna V. Korda, et al. "Relationships between changes in uric acid parameters metabolism and parameters of immunity and microbiota in patients with neuroendocrine-immune complex dysfunction." Journal of Education, Health and Sport 10, no. 2 (2020): 212–22. https://doi.org/10.5281/zenodo.4562975.

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<strong>Gozhenko Anatoliy I., Smagliy Vadym S., Korda Inna V., Badiuk Nataliya S., Zukow Walery, Kovbasnyuk Marta M.</strong>, <strong>Popovych Igor L. </strong><strong>Relationships between changes in uric acid parameters metabolism and parameters of immunity </strong><strong>and microbiota </strong><strong>in patients with neuroendocrine-immune complex dysfunction</strong><strong>. Journal of Education, Health and Sport. 2020;10(</strong><strong>2</strong><strong>):</strong><strong>212</strong><strong>-</strong><strong>222</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi

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Gozhenko, Anatoliy I., Vadym S. Smagliy, Inna V. Korda, Nataliya S. Badiuk, Walery Zukow, and Igor L. Popovych. "Features of immune status in different states of uric acid metabolism in female rats." Journal of Education, Health and Sport 9, no. 12 (2019): 167–80. https://doi.org/10.5281/zenodo.3632130.

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<strong>Gozhenko Anatoliy I, Smagliy Vadym S, Korda Inna V, Badiuk Nataliya S, </strong><strong>Zukow</strong> <strong>Walery, Popovych</strong> <strong>Igor L</strong><strong>. </strong><strong>Features of immune status in different states of uric acid metabolism in female rats</strong><strong>. </strong><strong>Journal of Education, Health and Sport. 2019;9(12):</strong><strong>167</strong><strong>-</strong><strong>180</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2019.09.12.01</strong><strong>9</strong> <strong>https://apcz.umk.pl/czasopis

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Gozhenko, Anatoliy I., Vadym S. Smagliy, Inna V. Korda, et al. "Relationships between parameters of uric acid exchange and immunity as well as microbiota in patients with neuroendocrine-immune complex dysfunction." Journal of Education, Health and Sport 10, no. 1 (2020): 165–75. https://doi.org/10.5281/zenodo.3733478.

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<strong>Gozhenko Anatoliy I., Smagliy Vadym S., Korda Inna V., Badiuk Nataliya S., Zukow Walery,</strong><strong> Kovbasnyuk</strong> <strong>Marta M.</strong>, <strong>Popovych Igor L.</strong> <strong>Relationships between parameters of uric acid exchange and immunity as well as microbiota in patients with neuroendocrine-immune complex dysfunction</strong><strong>. Journal of Education, Health and Sport. 2020;10(1):</strong><strong>1</strong><strong>65</strong><strong>-</strong><strong>1</strong><strong>75</strong><strong>. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.o

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Syniachenko, O. V., T. B. Bevzenko, O. O. Diadyk, M. V. Iermolaieva, E. D. Iegudina, and D. V. Pomazan. "CLINICAL AND MORPHOLOGICAL COMPARISON AT NEPHROPATHY IN PATIENTS WITH MICROSCOPIC POLYANGIITIS." Ukrainian Journal of Nephrology and Dialysis, no. 3(47) (August 25, 2015): 30–34. http://dx.doi.org/10.31450/ukrjnd.3(47).2015.07.

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Introduction. Morphological signs of renal pathology in microscopic polyangiitis, their connection with extrarenal manifestations of the disease and urine laboratory parameters, as well as the pathogenesis of such nephropathy remain insufficiently studied, what became the purpose and objectives of this study. Material and methods. Nephrobiopsy was made 12 patients. The study was performed on microscope «OlumpusBX40», «Olumpus - C3030 - ADU», «Olympus DP - Soft», «Olympus - AX70», «Olympus - DP50». Results and discussion. Damage of glomeruli, stroma, tubules and vessels was detected

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Bouchama, A., A. Cafege, W. Robertson, S. al-Dossary, and A. el-Yazigi. "Mechanisms of hypophosphatemia in humans with heatstroke." Journal of Applied Physiology 71, no. 1 (1991): 328–32. http://dx.doi.org/10.1152/jappl.1991.71.1.328.

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Hypophosphatemia is common in heatstroke, but little is known about its mechanism. We investigated 10 consecutive patients with heatstroke (mean age 58 +/- 2 yr) whose mean rectal temperature at admission was 42.3 +/- 0.2 degrees C. Eight patients presented with hypophosphatemia [0.48 +/- 0.08 mmol/l, normal range (NR) 0.8–1.4 mmol/l], associated with increased fractional excretion of phosphate (19.8 +/- 6.4%, NR 6–20%) relative to plasma phosphate levels and reduced renal threshold for phosphate (0.55 +/- 0.08 mmol/l glomerular filtrate, NR 0.8–1.4 mmol/l). Plasma parathyroid hormone (75.0 +/

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GIL, A., and V. Frajewicki. "POS-460 THE PREVALENCE OF HYPERURICEMIA IN PATIENTS WITH URINARY STONES AND HYPERURICOSURIA OR NORMAL URICOSURIA." Kidney International Reports 7, no. 2 (2022): S204. http://dx.doi.org/10.1016/j.ekir.2022.01.489.

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Awazu, Midori, Mie Arai, Shoko Ohashi, Hirotaka Takahashi, Takashi Sekine, and Kazushige Ikeda. "Tubular Dysfunction Mimicking Dent’s Disease in 2 Infants Born with Extremely Low Birth Weight." Case Reports in Nephrology and Dialysis 7, no. 1 (2017): 13–17. http://dx.doi.org/10.1159/000455828.

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Two preterm infants, with extremely low birth weight born at gestational weeks 24 and 25, showed generalized proximal tubular dysfunction during their stay in the neonatal intensive care unit, including glucosuria, low molecular weight proteinuria, phosphaturia, uricosuria, enzymuria (elevated urine N-acetyl-β-D-glucosaminidase), panaminoaciduria, and hypercalciuria, associated with renal calcification. Renal tubular acidosis was not present in either patient. DNA mutation analysis for Dent’s disease, performed in patient 1, was negative. Although both patients had rickets of prematurity, tubu

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Nouvenne, A., A. Ticinesi, F. Allegri, et al. "New pharmacologic approach to patients with idiopathic calcium nephrolithiasis and high uricosuria: Febuxostat vs allopurinol. A pilot study." European Journal of Internal Medicine 24 (October 2013): e64. http://dx.doi.org/10.1016/j.ejim.2013.08.155.

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Kanbay, Mehmet, Yalcin Solak, Baris Afsar, et al. "Serum Uric Acid and Risk for Acute Kidney Injury Following Contrast." Angiology 68, no. 2 (2016): 132–44. http://dx.doi.org/10.1177/0003319716644395.

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Contrast-induced acute kidney injury (CI-AKI) is a common cause of hospital-acquired acute kidney injury (AKI). We evaluated the evidence that uric acid (UA) plays a pathogenic role in CI-AKI. Ten studies were eligible for inclusion for meta-analysis. Hyperuricemia predicted risk for cases with AKI in prospective cohort studies. Higher levels of serum UA (SUA), as defined by the authors, were associated with a 2-fold increased risk to develop AKI (pooled odds ratio 2.03; 95% confidence interval [CI] 1.48-2.78). Significant heterogeneity was found in cohort studies ( P = .001, I2 = 85.7%). In 2

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Sriram, Damal Kandadai, Surendran Venkatesan, and Melvin George. "Lesinurad: a novel therapeutic option in the pharmacotherapy of gout." International Journal of Basic & Clinical Pharmacology 6, no. 1 (2016): 214. http://dx.doi.org/10.18203/2319-2003.ijbcp20164783.

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Gout is characterized by painful joint inflammation, most commonly in the first metatarsophalangeal joint, resulting from precipitation of monosodium urate crystals in a joint space. Current therapies for chronic gout include mainly allopurinol and febuxostat. Inspite of the availability of these medications for several years, a significant number of patients do not have adequate control of uric acid levels resulting in acute gout flares. Lesinurad is the most recent drug molecule approved by US FDA & EMA for the treatment of gout in patients with uncontrolled gout along with allopurinol.

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Vidyasagar, Sudha, Shivaram R. Komandla, Naresh K. Monigari, and Muralidhar V. Danturulu. "An Uncommon Cause of Pathological Fracture: Tenofovir-induced Osteomalacia and acquired Fanconi's Syndrome in a Retroviral Patient." Journal of Postgraduate Medicine, Education and Research 50, no. 3 (2016): 156–58. http://dx.doi.org/10.5005/jp-journals-10028-1210.

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ABSTRACT Here we report a 60-year-old female patient with retroviral illness on antiretroviral therapy with tenofovir/emitricitabine/ efavirenz since 4 years, who presented with fracture of the right 4th metatarsal and bone pains and was found to have hypophosphatemia with normal vitamin D, calcium, and parathormone levels. Further testing revealed elevated serum creatinine, phosphaturia, uricosuria, glycosuria, and metabolic acidosis supporting the diagnosis of Fanconi syndrome. Adverse drug reaction was suspected as the patient was on tenofovirbased regimen. Hence, it was stopped and, subseq

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Kuchma, Igor, Mykhaylo Korda, Mykola Klishch, Dariya Popovych, Xawery Żukow, and Igor Popovych. "Role of autonomous and endocrine factors in immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis." Journal of Education, Health and Sport 12, no. 5 (2022): 362–85. http://dx.doi.org/10.12775/jehs.2022.12.05.029.

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Background. We have previously shown that nitrogenous metabolites have immunomodulatory effects in healthy rats and humans as well as patients with dysfunction of neuroendocrine-immune complex, encephalopatia and chronic pyelonephritis. The purpose of this study is clarification of the role of neuro-endocrine factors in their immunotropic activity in patients with chronic pyelonephritis. Materials and Methods. The object of observation were 17 men (aged 24-70 years) with chronic pyelonephritis in remission. The plasma levels and urinary excretion of nitrogenous metabolites as well as parameter

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Sánchez-Briales, Paula, María Marques Vidas, Paula López-Sánchez, et al. "The Uricosuric Effect of SGLT2 Inhibitors Is Maintained in the Long Term in Patients with Chronic Kidney Disease and Type 2 Diabetes Mellitus." Journal of Clinical Medicine 13, no. 5 (2024): 1360. http://dx.doi.org/10.3390/jcm13051360.

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(1) Background: Sodium–glucose co-transporter 2 inhibitors (SGLT2is) increase uric acid excretion. The intensity of uricosuria is linked to glycosuria. (2) Methods: We aim to analyze the effect of SGLT2 inhibitors on urinary fractional excretion (FE) of uric acid and glucose in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) in a single-center retrospective study with patients with T2DM and CKD who started on treatment with SGLT2is. Patients on renal replacement therapy or with glucagon-like peptide-1 (GLP1) analogs were excluded. Subgroup analysis was performed

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Jaiswal, Dr Pritesh, and Dr Archana Dachewar. "A Systemic Literature Review of Vatarakta and Its Management through Ayurveda w.s.r. to Gout." Sanjeevani Darshan National - Journal of Ayurveda & Yoga 01, no. 02 (2023): 35–41. http://dx.doi.org/10.55552/sdnjay.2023.1205.

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In Ayurveda health means the state of Doshsamya, Agnisamya & Dhatusamya as well as wellness of Atma, Indriya & Mana. Acharya Charaka says that the man desirous of the happiness should observe rule which is related with the prevention of unborn disease and the cure of those which are already exist. Now a day, due to change in life style , people are enforced to undergo “Hetusevan “. Occurrence of Vatarakta on large scale is one of the outcomes of this modification. Vatarakta (Gout) is vata associated with Rakta which consist of swelling including burning pain in metatarsophalangeal join

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Roy, Ajitesh, Amarta Shankar Chowdhury, Arindam Ray, et al. "Diagnostic approach to rickets: an Endocrine Society of Bengal (ESB) consensus statement." Annals of Pediatric Endocrinology & Metabolism 29, no. 5 (2024): 284–307. http://dx.doi.org/10.6065/apem.2448044.022.

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Rickets, one of the leading causes of bony deformities and short stature, can be calciopenic (inciting event is defective intestinal calcium absorption) or phosphopenic (inciting event is phosphaturia). Early diagnosis and timely treatment of rickets are crucial for correction of the limb deformities. Guidelines exist for nutritional rickets, but the diagnosis and management of the relatively uncommon forms of rickets are complex. This consensus aims to formulate a simplified diagnostic approach for rickets, especially in resource-limited settings. The consensus statement has been formulated b

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Aslan, Gamze, Baris Afsar, Alan A. Sag, et al. "The Effect of Urine pH and Urinary Uric Acid Levels on the Development of Contrast Nephropathy." Kidney and Blood Pressure Research 45, no. 1 (2019): 131–41. http://dx.doi.org/10.1159/000504547.

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Background: Hyperuricemia may cause acute kidney injury by activating inflammatory, pro-oxidative and vasoconstrictive pathways. In addition, radiocontrast causes an acute uricosuria, potentially leading to crystal formation. We therefore aimed to investigate the effect of urine acidity and urine uric acid level on the development of contrast-induced nephropathy (CIN) in patients undergoing elective coronary angiography. Methods: We enrolled 175 patients who underwent elective coronary angiography. CIN was defined as a >25% increase in the serum creatinine levels relative to basal values 48

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Somasekhar, Bandi, Kaipa Vanaja, and Veeram Anjali. "Pharmacological Review on Uricosuric activity." Indian Journal of Pharmaceutical and Biological Research 6, no. 04 (2018): 38–42. http://dx.doi.org/10.30750/ijpbr.6.4.8.

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The naturally available uricosuric agents are Tinospora cardifolia, Allium sepa, Cajanus Cajan, Piper nigrum etc., Natural medicinal plants having no side effects are more preferred when compared to synthetic medications. Uricosuric agents increase the urinary excretion of uric acid hence the natural uricosuric agent is preferred to prevent many diseases like gout, arthritis, kidney stones etc., without side effect. Uricosuric medications are the substances that increase the excretion of uric acid in urine, thus reducing the concentration of uric acid in blood plasma. Prolonged and untreated h

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Bach, Mary H., and Peter A. Simkin. "Uricosuric drugs." Current Opinion in Rheumatology 26, no. 2 (2014): 169–75. http://dx.doi.org/10.1097/bor.0000000000000035.

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Popovych, Igor L., Anatoliy I. Gozhenko, Igor L. Kuchma, et al. "Immunotropic effects of so-called slag metabolites (creatinine, urea, uric acid and bilirubin) at rats." Journal of Education, Health and Sport 10, no. 11 (2020): 320–36. https://doi.org/10.12775/JEHS.2020.10.11.033.

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<strong>Popovych</strong> <strong>Igor L.</strong><strong>,</strong><strong> Gozhenko</strong> <strong>Anatoliy I., Kuchma Igor L., Zukow Walery, Bilas Volodymyra R.</strong><strong>,</strong><strong> Koval’chuk Galyna Y., Ivasivka Anzhela S.</strong> <strong>Immunotropic effects of so-called slag metabolites (creatinine, urea, uric acid and bilirubin) at rats</strong><strong>.</strong> <strong>Journal of Education, Health and Sport. </strong><strong>2020;10(11):3</strong><strong>20</strong><strong>-3</strong><strong>36</strong><strong>. eISSN 2391-8306

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CHRISTENSEN, FLEMMING. "Uricosuric Effect of Dicoumarol." Acta Medica Scandinavica 175, no. 4 (2009): 461–68. http://dx.doi.org/10.1111/j.0954-6820.1964.tb00594.x.

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Mandal, Asim K., Adriana Mercado, Andria Foster, Kambiz Zandi-Nejad, and David B. Mount. "Uricosuric targets of tranilast." Pharmacology Research & Perspectives 5, no. 2 (2017): e00291. http://dx.doi.org/10.1002/prp2.291.

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Hermanto, Faizal, and Sri Wahyuningsih. "In Vivo Uricosuric Effect of Red Betel Leaves (Piper crocatum RUIZ & PAV) Ethanol Extract." Jurnal Sains dan Kesehatan 6, no. 2 (2024): 269–73. http://dx.doi.org/10.25026/jsk.v6i2.2135.

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Hyperuricemia a condition where a person has high levels of uric acid in the blood. Red betel (Piper crocatum RUIZ & PAV) is a plant empirically used to reduce uric acid levels. This study aimed to determine the effective dose of red betel plant in reducing urinary uric acid levels in male Wistar rats with hyperuricemia. Hyperuricemia condition was obtained by giving chicken liver juice 25 mL/kg orally and potassium oxonate 250 mg/kg intraperitoneally. Red betel extract (RBE) is made by maceration using 50% ethanol. Male Wistar rats were divided into five groups: negative control (CMC-Na 0

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Bardin, Thomas, and Pascal Richette. "Novel uricosurics." Rheumatology 57, suppl_1 (2017): i42—i46. http://dx.doi.org/10.1093/rheumatology/kex433.

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Kuhlbäck, Börje, and Ahti Harjanne. "Zoxazolamine as a Uricosuric Agent." Acta Medica Scandinavica 170, no. 2 (2009): 129–40. http://dx.doi.org/10.1111/j.0954-6820.1961.tb00221.x.

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Hrytsak, Myroslava, Dariya Popovych, Nataliya Badiuk, and Ivanna Hrytsan. "Peculiarities of neuroendocrine and metabolic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats." Journal of Education, Health and Sport 11, no. 9 (2021): 862–75. http://dx.doi.org/10.12775/jehs.2021.11.09.103.

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Background. Earlier we found that the newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have similar neuroendocrine and metabolic effects on healthy old female rats significantly different from daily water. The aim of this study is to elucidate the effects of these mineral waters on the neuroendocrine status and metabolism of these animals. Materials and Methods. Experiment was performed on 50 healthy female Wistar rats. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the control group for 6 days injected a

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Slíva, Jiří. "Allopurinol and uricosurics." Vnitřní lékařství 71, no. 1 (2025): 24–26. https://doi.org/10.36290/vnl.2025.004.

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