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Relevant bibliographies by topics / Urinary kynurenine

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Academic literature on the topic 'Urinary kynurenine'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "Urinary kynurenine"

1

Saito, Kuniaki, Suwako Fujigaki, Melvyn P. Heyes, et al. "Mechanism of increases in l-kynurenine and quinolinic acid in renal insufficiency." American Journal of Physiology-Renal Physiology 279, no. 3 (2000): F565—F572. http://dx.doi.org/10.1152/ajprenal.2000.279.3.f565.

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Marked increases in metabolites of thel-tryptophan-kynurenine pathway, l-kynurenine and quinolinic acid (Quin), were observed in serum and cerebrospinal fluid (CSF) of both the rat and human with renal insufficiency. The mechanisms responsible for their accumulation after renal insufficiency were investigated. In patients with chronic renal insufficiency, elevated levels of serum l-kynurenine and Quin were reduced by hemodialysis. In renal-insufficient rats, Quin andl-kynurenine levels in serum, brain, and CSF were also increased parallel to the severity of renal insufficiency. Urinary excreti

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2

Noakes, Rowland R. "Effects of Tranilast on the Urinary Excretion of Kynurenic and Quinolinic Acid under Conditions of L Tryptophan Loading." International Journal of Tryptophan Research 6 (January 2013): IJTR.S12797. http://dx.doi.org/10.4137/ijtr.s12797.

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The pathogenesis of morphea and other cutaneous sclerosing disorders remain poorly understood. Although they are considered to be autoimmune disorders, abnormal tryptophan metabolism may be involved. Current therapy is directed to supressing the autoimmune response. Demonstration of a therapeutic response to manipulation of the kynurenine pathway would both support a role for abnormal tryptophan metabolism and offer additional targets for therapy. Tranilast is a 3-hydroxyanthranilic acid derivative known to target the kynurenine pathway. The aim of this study was to see if tranilast lowered th

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3

Chojnacki, Cezary, Tomasz Popławski, Jan Chojnacki, Michał Fila, Paulina Konrad, and Janusz Blasiak. "Tryptophan Intake and Metabolism in Older Adults with Mood Disorders." Nutrients 12, no. 10 (2020): 3183. http://dx.doi.org/10.3390/nu12103183.

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The role of serotonin in the pathogenesis of depression is well-documented, while the involvement of other tryptophan (TRP) metabolites generated in the kynurenine pathway is less known. The aim of this study was to assess the intake and metabolism of TRP in elderly patients with mood disorders. Ninety subjects in three groups, 30 subjects each, were enrolled in this study: controls (healthy young adults, group I) and elderly individuals without (group II) or with (group III) symptoms of mild and moderate depression, as assessed by the Hamilton Depression Rating Scale (HAM-D) and further refer

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4

Polyák, Helga, Zsolt Galla, Cecilia Rajda, Péter Monostori, Péter Klivényi, and László Vécsei. "Plasma and Visceral Organ Kynurenine Metabolites Correlate in the Multiple Sclerosis Cuprizone Animal Model." International Journal of Molecular Sciences 26, no. 3 (2025): 976. https://doi.org/10.3390/ijms26030976.

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The cuprizone (CPZ) model of multiple sclerosis (MS) is excellent for studying the molecular differences behind the damage caused by poisoning. Metabolic differences in the kynurenine pathway (KP) of tryptophan (TRP) degradation are observed in both MS and a CPZ mouse model. Our goal was to analyze the kynurenine, serotonin, and indole pathways of TRP degradation on the periphery, in the neurodegenerative processes of inflammation. In our study, mice were fed with 0.2% CPZ toxin for 5 weeks. We examined the metabolites in the three pathways of TRP breakdown in urine, plasma, and relevant visce

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5

de Vries, Laura V., Isidor Minović, Casper F. M. Franssen, et al. "The tryptophan/kynurenine pathway, systemic inflammation, and long-term outcome after kidney transplantation." American Journal of Physiology-Renal Physiology 313, no. 2 (2017): F475—F486. http://dx.doi.org/10.1152/ajprenal.00690.2016.

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Tryptophan is metabolized along the kynurenine pathway, initially to kynurenine, and subsequently to cytotoxic 3-hydroxykynurenine. There is increasing interest in this pathway because of its proinflammatory nature, and drugs interfering in it have received increasing attention. We aimed to investigate whether serum and urinary parameters of the tryptophan/kynurenine pathway, and particularly cytotoxic 3-hydroxykynurenine, are associated with systemic inflammation and long-term outcome in renal transplant recipients (RTR). Data were collected in outpatient RTR with a functioning graft for >

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6

Landfried, Karin, Wentao Zhu, Magdalena C. Waldhier, et al. "Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase." Blood 118, no. 26 (2011): 6971–74. http://dx.doi.org/10.1182/blood-2011-06-357814.

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Abstract Induction of indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme in tryptophan degradation along the kynurenine pathway, acts as a potent immunoregulatory loop. To address its role in human allogeneic stem cell transplantation, we measured major tryptophan metabolites, such as quinolinic acid and kynurenine, in serial urine specimens from 51 patients by liquid chromatography-tandem mass spectrometry. Samples were collected between admission and day 90 after transplantation, and metabolite levels were correlated with early clinical events and outcome. In selected patients, IDO

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7

Marfella, A., R. A. Satriano, C. Polese, M. Perna, and M. Pisani. "Urinary Neopterin and Kynurenine in Herpes gestationis." Dermatology 183, no. 1 (1991): 56. http://dx.doi.org/10.1159/000247636.

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8

Engin, Ayse Basak, Bensu Karahalil, Ali Esat Karakaya, and Atilla Engin. "Exposure to Helicobacter pylori and Serum Kynurenine to Tryptophan Ratio in Patients with Gastric Cancer." Pteridines 21, no. 1 (2010): 110–20. http://dx.doi.org/10.1515/pteridines.2010.21.1.110.

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Abstract In Helicobacter pylori seropositive individuals, the subsequent risk of non-cardia gastric cancer development is frequently attributed to the infection agent. Although the link between inflammation and gastric cancer is formally recognized, the molecular basis of evading mechanisms of Helicobacter pylori from host immune system remains unclear. The aim of this study was to determine the effect of systemic factors in gastric cancer patients such as serum kynurenine to tryptophan ratios, neopterin, nitric oxide and urinary biopterin levels which may sustain the persistence of Helicobact

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9

Chojnacki, Cezary, Aleksandra Błońska, Paulina Konrad, Marcin Chojnacki, Marcin Podogrocki, and Tomasz Poplawski. "Changes in Tryptophan Metabolism on Serotonin and Kynurenine Pathways in Patients with Irritable Bowel Syndrome." Nutrients 15, no. 5 (2023): 1262. http://dx.doi.org/10.3390/nu15051262.

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(1) Background: L-tryptophan is a substrate for the synthesis of many biological compounds through the serotonin and kynurenine pathways. These compounds have a significant influence on gastrointestinal functions and mental processes. The aim of the study was to evaluate the urinary excretion of selected tryptophan metabolites in patients with constipation-predominant and diarrhoea-predominant irritable bowel syndrome (IBS-C and IBS-D, respectively), related to somatic and mental symptoms. (2) Methods: 120 people were included in the study and three groups were distinguished, with 40 individua

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10

Chojnacki, Marcin, Aleksandra Błońska, Aleksandra Kaczka, et al. "Assessment of the Gut Microbiome in Patients with Coexisting Irritable Bowel Syndrome and Chronic Fatigue Syndrome." Nutrients 17, no. 13 (2025): 2232. https://doi.org/10.3390/nu17132232.

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Background: The gut microbiome is a key modulator of the gut–brain axis and may contribute to the pathophysiology of both gastrointestinal and systemic disorders. This study aimed to evaluate gut microbiota composition and tryptophan/phenylalanine metabolism in women with unclassified irritable bowel syndrome (IBS-U), with or without coexisting chronic fatigue syndrome (CFS). Methods: Eighty women were enrolled and divided into two groups: IBS-U without CFS (Group I, n = 40) and IBS-U with coexisting CFS (Group II, n = 40). Microbial composition and diversity were assessed using the GA-map™ Dy

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Books on the topic "Urinary kynurenine"

1

Naleem, Wazeer A. A study of urinary kynurenine metabolites in pre-pubertal, pubertal and post-pubertal male offsprings of families with family history negative and family history positive of alcoholism. University of Surrey, 1995.

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