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1

Dr, Cooper David N., and Lemoine Nicholas R, eds. Gene therapy. Bios Scientific Publishers, 1996.

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2

Arslanoglu, Alper. Studies of the adenovirus 5 L1 gene aimed at developing L1 gene deficiencies for use in gene therapy vectors. typescript, 1999.

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3

Miller, Davin Philip. Characterisation of the entomopoxvirus spheroidin gene promoter and its use in heterologous gene expression. Oxford Brookes University, 1995.

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4

1959-, Rolland Alain, and Sullivan Sean M, eds. Pharmaceutical gene delivery systems. M. Decker, 2003.

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5

A, Lidbury Brett, and Mahalingam Suresh, eds. Gene profiling in drug design. Taylor & Francis, 2008.

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6

I, Mahato Ram, and Kim Sung Wan, eds. Pharmaceutical perspectives of nucleic acid-based therapeutics. Taylor & Francis, 2002.

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7

Great Britain. Gene Therapy Advisory Committee. Report on the potential use of gene therapy in utero. Department of Health, 1998.

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8

Rho, Jong M. Epilepsy: Mechanisms, models, and translational perspectives. CRC Press, 2010.

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9

R, Bertolotti, and Ozawa Keiya 1953-, eds. Autologous and cancer stem cell gene therapy. World Scientific, 2008.

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10

J, Ferretti Joseph, American Society for Microbiology, International Association of Biological Standardization., and International ASM Conference on Streptococcal Genetics (4th : 1994 : Santa Fe, N.M.), eds. Genetics of streptococci, enterococci, and lactococci: Santa Fee [i.e. Fe], NM, USA, May 15-18, 1994. Karger, 1995.

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11

Stoltenberg, Scott F., ed. Genes and the Motivation to Use Substances. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-0653-6.

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12

Geza, Hrazdina, ed. Use of agriculturally important genes in biotechnology. IOS Press, 2000.

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13

1947-, Scanlon Kevin J., and Kashani-Sabet Mohammed, eds. Ribozymes in the gene therapy of cancer. R.G. Landes Co., 1998.

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14

A, Findeis Mark, ed. Nonviral vectors for gene therapy: Methods and protocols. Humana Press, 2001.

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15

R, Lemoine Nicholas, and Epenetos A. A, eds. Mutant oncogenes: Targets for therapy. Chapman & Hall Medical, 1993.

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16

Brenner, Malcolm K., and Mien-chie Hung. Cancer gene therapy by viral and non-viral vectors. Wiley Balckwell, 2014.

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17

S, Onaivi Emmanuel, ed. Biology of marijuana: From gene to behavior. Taylor & Francis, 2002.

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18

M, Rho Jong, Sankar Raman, and Stafstrom Carl Ernest, eds. Epilepsy: Mechanisms, models, and translational perspectives. Taylor & Francis, 2010.

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19

Kole, Ryszard, Adrian Krainer, and Bruce Sullenger. Abstracts of papers presented at the 2010 meeting on RNA & oligonucleotide therapeutics: April 7-April 10, 2010. Cold Spring Harbor Laboratory, 2010.

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20

Baruah, Dhani Ram. It was a distant dream now it is the reality in the entire planet of diseased and unhealthy human genome. Dr. Dhani Ram Baruah Heart City & City of Human Genome, The Institute of Applied Human Genetic Engineering, 2010.

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21

C, Taylor Jessica, and Williams Amelia J, eds. Research progress in antisense elements (genetics). Nova Science, 2008.

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22

Mouldy, Sioud, ed. siRNA and miRNA gene silencing: From bench to bedside. Humana Press, 2009.

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23

A, Liu Margaret, Hilleman Maurice R. 1942-, and Kurth Reinhard 1942-, eds. DNA vaccines: A new era in vaccinology. New York Academy of Sciences, 1995.

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24

Devlin, Keith J. The maths gene: Why everyone has it, but most people don't use it. Weidenfeld & Nicolson, 2000.

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25

Falk Symposium (88th 1995 Basel, Switzerland). Molecular diagnosis and gene therapy: Proceedings of the 88th Falk Symposium (part III of the Basel Liver Week), held in Basel, Switzerland, October 22-23, 1995. Kluwer Academic Publishers, 1996.

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26

Louis-Marie, Houdebine, ed. Transgenic animals: Generation and use. Harwood Academic Publishers, 1997.

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27

Matt, Kalaycio, ed. Biologic therapy of leukemia. Humana Press, 2003.

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28

Lombardi, Rocco Anthony. GAG and ENV trans-dominant mutants for use in ANTI-HIV-1 gene therapy. National Library of Canada, 1996.

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29

Walker, Keith J. Chemokines: Types, functions, and structural characteristics. Nova Science Publishers, 2010.

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30

Keller, George H. DNA probes. Macmillan, 1989.

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31

McCann, Shaun R. Molecules, genes, and gene therapy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198717607.003.0009.

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The twenty-first century has brought many innovations in haematology, with improved diagnostic technology, which may inform treatment choices for malignant diseases, and a better understanding of the genetics and/or epigenetics underlying many diseases. Unfortunately, the aetiology of most of these diseases still eludes us, and some common diseases such as sickle cell disease await simple, inexpensive, and widely available curative treatment. For reasons that are often obscure, some diseases have become fashionable and attract large research financial backing, whereas some do not. With the adv
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32

(Editor), Kazunari Taira, Kazunori Kataoka (Editor), and Takuro Niidome (Editor), eds. Non-viral Gene Therapy: Gene Design and Delivery. Springer, 2005.

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33

Joyner, Alexandra, ed. Gene Targeting. Oxford University Press, 1999. http://dx.doi.org/10.1093/oso/9780199637928.001.0001.

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Since the publication of the first edition of Gene Targeting: A Practical Approach in 1993 there have been many advances in gene targeting and this new edition has been thoroughly updated and rewritten to include all the major new techniques. It provides not only tried-and-tested practical protocols but detailed guidance on their use and applications. As with the previous edition Gene Targeting: A Practical Approach 2e concentrates on gene targeting in mouse ES cells, but the techniques described can be easily adapted to applications in tissue culture including those for human cells. The first
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34

Biloshytsky, Vadym, and Roman Cregg. Pioneering use of gene therapy for pain. Edited by Paul Farquhar-Smith, Pierre Beaulieu, and Sian Jagger. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198834359.003.0083.

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The landmark paper discussed in this chapter is ‘Gene therapy for pain: Results of a Phase I clinical trial’, published by Fink et al. in 2011. In this study, the first of its kind, researchers studied the efficacy and safety of a modified herpes simplex virus (HSV) vector used to deliver PENK, which encodes proenkephalin, which is cleaved into the enkephalin peptides Met-enkephalin and Leu-enkephalin, which induce analgesia by acting on opioid receptors. The development of the HSV vector was based in part on results studies in which adenovirus, adeno-associated virus, or non-viral vectors wer
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35

Gene vaccination: Theory and practice. Spring-Verlag, 1998.

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36

Franke, Barbara, and Jan K. Buitelaar. Gene–environment interactions. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198739258.003.0005.

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ADHD is highly heritable, but environmental factors also play significant roles in disease aetiology and outcome. Genetic and environmental influences are likely to show different types of interplay, with gene–environment interactions (G×E) playing a part. Different models of G×E exist, with the most frequently investigated in ADHD up to the present being the diathesis–stress and differential susceptibility models. The most frequently studied have been monoaminergic genes, often based on a single genetic variant. Only a single genome-wide study has been reported thus far. Environmental factors
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37

(Editor), D. Cooper, and N. Lemoine (Editor), eds. GENE THERAPY (Human Molecular Genetics Ser.)). Garland Science, 1996.

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38

Gene profiles in drug design. Taylor & Francis, 2008.

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39

Ernst, Wagner, Dexi Liu, and Leaf Huang. Nonviral Vectors for Gene Therapy: Lipid- and Polymer-Based Gene Transfer. Elsevier Science & Technology Books, 2014.

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40

Cassidy, Jim, Donald Bissett, Roy A. J. Spence OBE, Miranda Payne, and Gareth Morris-Stiff. Surgical oncology. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199689842.003.0003.

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Cancer is a disease of the genes. In the last two decades new technologies have allowed us to interrogate the genome more efficiently and faster. This has led to new therapies and improved understanding of cancers. It is clear the few cancers are caused by just one gene defect and in these rare cases the defective gene or its product is a target for therapeutic intervention. The bigger challenge now is to use this paradigm against multi-genic cancers which are far more common and more complex in their genetic makeup.
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41

Kim, Sung Wan, and Ram I. Mahato. Pharmaceutical Perspectives of Nucleic Acid-Based Therapeutics. Taylor & Francis Group, 2002.

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42

Brooks, Gavin. Gene Therapy: The Use of DNA as a Drug. Pharmaceutical Press, 2002.

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43

Monteggia, Lisa M., and Wei Xu. Methods for In Vivo Gene Manipulation. Edited by Dennis S. Charney, Eric J. Nestler, Pamela Sklar, and Joseph D. Buxbaum. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190681425.003.0004.

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Recent advances in mouse genetics have opened many new avenues of research in which to explore gene function in the brain, and contributions to the pathophysiology and treatment of psychiatric disorders. The use of the mouse to explore gene function has contributed a better understanding of the role of specific genes in the nervous system including their influence on neural circuits and complex behavior.This chapter explores current approaches to manipulate gene function in a mouse. Genetically modified mice allow for the investigation of a particular gene in vivo. The approaches discussed hig
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44

(Editor), Brett A. Lidbury, and Suresh Mahalingam (Editor), eds. Gene Profiling in Drug Design. CRC, 2008.

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45

(Editor), Mien-Chie Hung, Leaf Huang (Editor), and Ernst Wagner (Editor), eds. Nonviral Vectors for Gene Therapy. Academic Press, 1999.

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46

Ernst, Wagner, Mien-Chie Hung, and Leaf Huang. Nonviral Vectors for Gene Therapy. Elsevier Science & Technology Books, 1999.

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47

(Editor), H. E. Blum, C. H. Wu (Editor), and G. Y. Wu (Editor), eds. Molecular Diagnosis and Gene Therapy (Falk Symposium). Springer, 1996.

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48

Raz, E. Gene Vaccination: Theory and Practice (Principles and Practice). Springer-Verlag Telos, 1998.

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49

Stallings, Michael C., Ian R. Gizer, and Kelly C. Young-Wolff. Genetic Epidemiology and Molecular Genetics. Edited by Kenneth J. Sher. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199381678.013.002.

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The tools of genetic epidemiology—family, adoption, and twin studies—show convincingly that substance use behavior and substance use disorders are influenced by both genetic and familial and extrafamilial environmental factors. Environmental factors appear to play a more influential role in the early stages of substance use, whereas genetic factors become more important in the development of problem use and substance use disorder. Moreover, some genetic effects are likely conditional on conducive environments; research employing both behavior genetic approaches and measured genes point to impo
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50

Wade, Tracey D., and Cynthia Bulik. Genetic Influences on Eating Disorders. Edited by W. Stewart Agras and Athena Robinson. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780190620998.013.5.

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The current chapter reviews our progress in understanding how genes influence eating disorders by addressing the following areas: (1) how recognition of genetic influences on eating disorders emerged; (2) the complexities of gene environment interplay; (3) what twin studies can tell us about gene environment interplay, and (4) the current state of molecular genetic studies. It is concluded that both genes and nonshared environment play a critical role in the explanatory framework for the etiology of eating disorders. Shared environment is likely to contribute to the development of cognition an
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