Log in

Relevant bibliographies by topics / Usp gene / Journal articles

To see the other types of publications on this topic, follow the link: Usp gene.

Journal articles on the topic 'Usp gene'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Usp gene.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Alieh, Lotfi Nejad Mansour Amin Shekoofeh Sadat Etemadzadeh Mohammad Hossein Rezaeian. "DISTRIBUTION OF THE USP GENE IN UROPATHOGENIC ESCHERICHIA COLI FROM PATIENTS WITH URINARY TRACT INFECTION AND INVESTIGATION OF ANTIBIOTIC RESISTANCE." Indo American Journal of Pharmaceutical Sciences 04, no. 10 (2017): 3451–57. https://doi.org/10.5281/zenodo.1001732.

Full text

Abstract:

Urinary tract infection (UTI) is one of the most frequent infectious diseases around the world that caused by uropathogenic Escherichia coli (UPEC). Uropathogenic-specific protein (usp) is homologous to the Vibrio cholerae zonula occludens toxin gene wich is found in all common serogroups of UPEC. this study was performed to detect the distribution of usp and antibiotic resistance properties in E. coli strains isolated from patients with UTIs. For this purpose, samples were collected from patients and the strains which were biochemically confirmed as E. coli- positive used for detection of usp

APA, Harvard, Vancouver, ISO, and other styles

2

Lai, Yun Mei, Myo Thura Zaw, Shamsul Bahari Shamsudin, and Zaw Lin. "Evaluation of PAIusp subtyping to characterize uropathogenic E. coli isolates." Journal of Infection in Developing Countries 10, no. 10 (2016): 1053–58. http://dx.doi.org/10.3855/jidc.6944.

Full text

Abstract:

Introduction: Uropathogenic virulence factors have been identified by comparing the prevalence of these among urinary tract isolates and environmental strains. The uropathogenic-specific protein (USP) gene is present on the pathogenicity island (PAI) of uropathogenic Escherichia coli (UPEC) and, depending on its two diverse gene types and the sequential patterns of three open reading frame units (orfUs) following it, there is a method to characterize UPEC epidemiologically called PAIusp subtyping. Methodology: A total of 162 UPEC isolates from Sabah, Malaysia, were tested for the presence of t

APA, Harvard, Vancouver, ISO, and other styles

3

Kato, Yasuhiko, Kaoru Kobayashi, Shigeto Oda, Norihisa Tatarazako, Hajime Watanabe, and Taisen Iguchi. "Cloning and characterization of the ecdysone receptor and ultraspiracle protein from the water flea Daphnia magna." Journal of Endocrinology 193, no. 1 (2007): 183–94. http://dx.doi.org/10.1677/joe-06-0228.

Full text

Abstract:

cDNAs encoding the ecdysone receptor (EcR) and ultra spiracle (USP) protein were cloned from the water flea Daphnia magna (Crustacea: Cladocera). The deduced EcR and USP amino acid sequences showed a high degree of homology to those of other crustaceans as well as insects. We isolated three isoforms of EcR that differ in the A/B domain. Quantitative PCR analysis indicated differing temporal expression patterns of the EcR isoforms during the molting period and demonstrated that the expression of one subtype correlated well with the timing of molt. Using cDNAs encoding EcR and USP, we constructe

APA, Harvard, Vancouver, ISO, and other styles

4

Isokpehi, Raphael D., Shaneka S. Simmons, Angela U. Makolo, et al. "Insights into Functions of Universal Stress Proteins Encoded by Genomes of Gastric Cancer Pathogen Helicobacter pylori and Related Bacteria." Pathogens 14, no. 3 (2025): 275. https://doi.org/10.3390/pathogens14030275.

Full text

Abstract:

The genes that encode the universal stress protein (USP) family domain (pfam00582) aid the survival of bacteria in specific host or habitat-induced stress conditions. Genome sequencing revealed that the genome of Helicobacter pylori, a gastric cancer pathogen, typically contains one USP gene, while related helicobacters have one or two distinct USP genes. However, insights into the functions of Helicobacteraceae (Helicobacter and Wolinella) USP genes are still limited to inferences from large-scale genome sequencing. Thus, we have combined bioinformatics and visual analytics approaches to cond

APA, Harvard, Vancouver, ISO, and other styles

5

BERGMAN, Thomas, Vincent C. HENRICH, Uwe SCHLATTNER, and Markus LEZZI. "Ligand control of interaction in vivo between ecdysteroid receptor and ultraspiracle ligand-binding domain." Biochemical Journal 378, no. 3 (2004): 779–84. http://dx.doi.org/10.1042/bj20031302.

Full text

Abstract:

Ecdysteroids (Ecs) enhance the formation of Ec receptor–ultraspiracle protein (EcR–USP) heterodimers which regulate gene transcription. To study EcR–USP heterodimerization, fusion proteins were constructed from the LBDs (ligand-binding domains) of Drosophila EcR or USP and the activation or DNA-binding region of GAL4 respectively. Reporter gene (lacZ) activation was fully dependent on the co-expression of the two fusion proteins and thus constitutes a reliable measure for the interaction in vivo between the two LBDs in the yeast cell. To identify structures involved in heterodimerization, a to

APA, Harvard, Vancouver, ISO, and other styles

6

Lan, Que, Kiyoshi Hiruma, Xiao Hu, Marek Jindra, and Lynn M. Riddiford. "Activation of a Delayed-Early Gene Encoding MHR3 by the Ecdysone Receptor Heterodimer EcR-B1–USP-1 but Not by EcR-B1–USP-2." Molecular and Cellular Biology 19, no. 7 (1999): 4897–906. http://dx.doi.org/10.1128/mcb.19.7.4897.

Full text

Abstract:

ABSTRACT MHR3, a homolog of the retinoid orphan receptor (ROR), is a transcription factor in the nuclear hormone receptor family that is induced by 20-hydroxyecdysone (20E) in the epidermis of the tobacco hornworm, Manduca sexta. Its 2.7-kb 5′ flanking region was found to contain four putative ecdysone receptor response elements (EcREs) and a monomeric (GGGTCA) nuclear receptor binding site. Activation of this promoter fused to a chloramphenicol acetyltransferase (CAT) reporter by 2 μg of 20E per ml inManduca GV1 cells was similar to that of endogenous MHR3, with detectable CAT by 3 h. When th

APA, Harvard, Vancouver, ISO, and other styles

7

Galant, Christine, Joel Marchandise, Maria S. Stoenoiu та ін. "Overexpression of ubiquitin-specific peptidase 15 in systemic sclerosis fibroblasts increases response to transforming growth factor β". Rheumatology 58, № 4 (2019): 708–18. http://dx.doi.org/10.1093/rheumatology/key401.

Full text

Abstract:

Abstract Objective Ubiquitination of proteins leads to their degradation by the proteasome, and is regulated by ubiquitin ligases and substrate-specific ubiquitin-specific peptidases (USPs). The ubiquitination process also plays important roles in the regulation of cell metabolism and cell cycle. Here, we found that the expression of several USPs is increased in SSc tenosynovial and skin biopsies, and we demonstrated that USP inhibition decreases TGF-β signalling in primary fibroblast cell lines. Methods High-density transcriptomic studies were performed using total RNA obtained from SSc tenos

APA, Harvard, Vancouver, ISO, and other styles

8

Rihtar, Erik, Darja Žgur Bertok, and Zdravko Podlesek. "The Uropathogenic Specific Protein Gene usp from Escherichia coli and Salmonella bongori is a Novel Member of the TyrR and H-NS Regulons." Microorganisms 8, no. 3 (2020): 330. http://dx.doi.org/10.3390/microorganisms8030330.

Full text

Abstract:

The Escherichia coli PAIusp is a small pathogenicity island encoding usp, for the uropathogenic specific protein (Usp), a genotoxin and three associated downstream imu1-3 genes that protect the producer against its own toxin. Bioinformatic analysis revealed the presence of the PAIusp also in publically available Salmonella bongori and Salmonella enterica subps. salamae genome sequences. PAIusp is in all examined sequences integrated within the aroP-pdhR chromosomal intergenic region. The focus of this work was identification of the usp promoter and regulatory elements controlling its activity.

APA, Harvard, Vancouver, ISO, and other styles

9

Hall, B. L., and C. S. Thummel. "The RXR homolog ultraspiracle is an essential component of the Drosophila ecdysone receptor." Development 125, no. 23 (1998): 4709–17. http://dx.doi.org/10.1242/dev.125.23.4709.

Full text

Abstract:

Pulses of the steroid hormone ecdysone function as key temporal signals during insect development, coordinating the major postembryonic developmental transitions, including molting and metamorphosis. In vitro studies have demonstrated that the EcR ecdysone receptor requires an RXR heterodimer partner for its activity, encoded by the ultraspiracle (usp) locus. We show here that usp exerts no apparent function in mid-third instar larvae, when a regulatory hierarchy prepares the animal for the onset of metamorphosis. Rather, usp is required in late third instar larvae for appropriate developmenta

APA, Harvard, Vancouver, ISO, and other styles

10

Brodu, Véronique, Bruno Mugat, Jean-Yves Roignant, Jean-Antoine Lepesant, and Christophe Antoniewski. "Dual Requirement for the EcR/USP Nuclear Receptor and the dGATAb Factor in an Ecdysone Response inDrosophila melanogaster." Molecular and Cellular Biology 19, no. 8 (1999): 5732–42. http://dx.doi.org/10.1128/mcb.19.8.5732.

Full text

Abstract:

ABSTRACT The EcR/USP nuclear receptor controls Drosophilametamorphosis by activating complex cascades of gene transcription in response to pulses of the steroid hormone ecdysone at the end of larval development. Ecdysone release provides a ubiquitous signal for the activation of the receptor, but a number of its target genes are induced in a tissue- and stage-specific manner. Little is known about the molecular mechanisms involved in this developmental modulation of the EcR/USP-mediated pathway. Fbp1 is a good model of primary ecdysone response gene expressed in the fat body for addressing thi

APA, Harvard, Vancouver, ISO, and other styles

11

Cakouros, Dimitrios, Tasman J. Daish, and Sharad Kumar. "Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues." Journal of Cell Biology 165, no. 5 (2004): 631–40. http://dx.doi.org/10.1083/jcb.200311057.

Full text

Abstract:

The steroid hormone ecdysone regulates moulting, cell death, and differentiation during insect development. Ecdysone mediates its biological effects by either direct activation of gene transcription after binding to its receptor EcR–Usp or via hierarchical transcriptional regulation of several primary transcription factors. In turn, these transcription factors regulate the expression of several downstream genes responsible for specific biological outcomes. DRONC, the Drosophila initiator caspase, is transcriptionally regulated by ecdysone during development. We demonstrate here that the dronc

APA, Harvard, Vancouver, ISO, and other styles

12

Williams, Baraka S., Raphael D. Isokpehi, Andreas N. Mbah, et al. "Functional Annotation Analytics of Bacillus Genomes Reveals Stress Responsive Acetate Utilization and Sulfate Uptake in the Biotechnologically Relevant Bacillus megaterium." Bioinformatics and Biology Insights 6 (January 2012): BBI.S7977. http://dx.doi.org/10.4137/bbi.s7977.

Full text

Abstract:

Bacillus species form an heterogeneous group of Gram-positive bacteria that include members that are disease-causing, biotechnologically-relevant, and can serve as biological research tools. A common feature of Bacillus species is their ability to survive in harsh environmental conditions by formation of resistant endospores. Genes encoding the universal stress protein (USP) domain confer cellular and organismal survival during unfavorable conditions such as nutrient depletion. As of February 2012, the genome sequences and a variety of functional annotations for at least 123 Bacillus isolates

APA, Harvard, Vancouver, ISO, and other styles

13

Martínez-Ramírez, Rachell, Valeria Toro-Díaz Toro-Díaz, Pearl Akamine, Kimberly Ruiz-Rosado, Ignacio Pino, and Abel Baerga-Ortiz. "Abstract 713: Monoclonal antibodies for the detection of the uropathogenic specific protein (USP): A bacterial genotoxin linked to colorectal cancer." Cancer Research 82, no. 12_Supplement (2022): 713. http://dx.doi.org/10.1158/1538-7445.am2022-713.

Full text

Abstract:

Abstract The Uropathogenic Specific Protein (USP) is an E. coli genotoxin nuclease primarily associated with urinary tract infections. Previous efforts in our laboratory found the USP gene in stool samples; more frequently found in stool samples from adenoma and CRC patients than in samples from healthy individuals. New efforts in our laboratory aim to find the USP protein in the same population of patient samples and this may require anti-USP antibodies, which at present are not commercially available. In this work, we report the first anti-USP monoclonal antibodies (mAbs) for the detection o

APA, Harvard, Vancouver, ISO, and other styles

14

Kozlova, Tatiana, and Carl S. Thummel. "Spatial patterns of ecdysteroid receptor activation during the onset ofDrosophilametamorphosis." Development 129, no. 7 (2002): 1739–50. http://dx.doi.org/10.1242/dev.129.7.1739.

Full text

Abstract:

Ecdysteroid signaling in insects is transduced by a heterodimer of the EcR and USP nuclear receptors. In order to monitor the temporal and spatial patterns of ecdysteroid signaling in vivo we established transgenic animals that express a fusion of the GAL4 DNA binding domain and the ligand binding domain (LBD) of EcR or USP, combined with a GAL4-dependent lacZ reporter gene. The patterns of β-galactosidase expression in these animals indicate where and when the GAL4-LBD fusion protein has been activated by its ligand in vivo. We show that the patterns of GAL4-EcR and GAL4-USP activation at the

APA, Harvard, Vancouver, ISO, and other styles

15

Tran, HT, S. Shaaban, HB Askari, PG Walfish, AS Raikhel, and TR Butt. "Requirement of co-factors for the ligand-mediated activity of the insect ecdysteroid receptor in yeast." Journal of Molecular Endocrinology 27, no. 2 (2001): 191–209. http://dx.doi.org/10.1677/jme.0.0270191.

Full text

Abstract:

In insects, a steroid hormone 20-hydroxyecdysone has an important role in regulating critical events such as development and reproduction. The action of 20-hydroxyecdysone is mediated by its binding to the ecdysteroid receptor (EcR), which requires a heterodimeric partner, ultraspiracle protein (USP), a homologue of the retinoid X receptor (RXR). The EcR-USP heterodimer represents a functional receptor complex capable of initiating transcription of early genes. Our goal was to establish a ligand-dependent transactivation system in yeast utilizing an insect EcR-USP heterodimer. This has been ac

APA, Harvard, Vancouver, ISO, and other styles

16

Samanta, Sintu, Priyanka Biswas, Arka Banerjee, et al. "A universal stress protein in Mycobacterium smegmatis sequesters the cAMP-regulated lysine acyltransferase and is essential for biofilm formation." Journal of Biological Chemistry 295, no. 6 (2019): 1500–1516. http://dx.doi.org/10.1074/jbc.ra119.011373.

Full text

Abstract:

Universal stress proteins (USPs) are present in many bacteria, and their expression is enhanced under various environmental stresses. We have previously identified a USP in Mycobacterium smegmatis that is a product of the msmeg_4207 gene and is a substrate for a cAMP-regulated protein lysine acyltransferase (KATms; MSMEG_5458). Here, we explored the role of this USP (USP4207) in M. smegmatis and found that its gene is present in an operon that also contains genes predicted to encode a putative tripartite tricarboxylate transporter (TTT). Transcription of the TTT-usp4207 operon was induced in t

APA, Harvard, Vancouver, ISO, and other styles

17

Isokpehi, Raphael D., Dominique S. McInnis, Antoinette M. Destefano, et al. "Bioinformatics Investigations of Universal Stress Proteins from Mercury-Methylating Desulfovibrionaceae." Microorganisms 9, no. 8 (2021): 1780. http://dx.doi.org/10.3390/microorganisms9081780.

Full text

Abstract:

The presence of methylmercury in aquatic environments and marine food sources is of global concern. The chemical reaction for the addition of a methyl group to inorganic mercury occurs in diverse bacterial taxonomic groups including the Gram-negative, sulfate-reducing Desulfovibrionaceae family that inhabit extreme aquatic environments. The availability of whole-genome sequence datasets for members of the Desulfovibrionaceae presents opportunities to understand the microbial mechanisms that contribute to methylmercury production in extreme aquatic environments. We have applied bioinformatics r

APA, Harvard, Vancouver, ISO, and other styles

18

Antoniewski, C., M. Laval, A. Dahan, and J. A. Lepesant. "The ecdysone response enhancer of the Fbp1 gene of Drosophila melanogaster is a direct target for the EcR/USP nuclear receptor." Molecular and Cellular Biology 14, no. 7 (1994): 4465–74. http://dx.doi.org/10.1128/mcb.14.7.4465-4474.1994.

Full text

Abstract:

The transcription of the Drosophila melanogaster Fbp1 gene is induced by the steroid hormone 20-hydroxyecdysone and restricted to the late-third-instar fat body tissue. In a previous study we showed that the -68 to -138 region relative to the transcription start site acts as an ecdysone-dependent third-instar fat body-specific enhancer in a transgenic assay. Here we report that seven nucleoprotein complexes are formed in vitro on this enhancer when a nuclear extract from late-third-instar fat body is used in a gel shift assay. Accurate mapping of the binding sites of the complexes revealed a r

APA, Harvard, Vancouver, ISO, and other styles

19

Antoniewski, C., M. Laval, A. Dahan, and J. A. Lepesant. "The ecdysone response enhancer of the Fbp1 gene of Drosophila melanogaster is a direct target for the EcR/USP nuclear receptor." Molecular and Cellular Biology 14, no. 7 (1994): 4465–74. http://dx.doi.org/10.1128/mcb.14.7.4465.

Full text

Abstract:

The transcription of the Drosophila melanogaster Fbp1 gene is induced by the steroid hormone 20-hydroxyecdysone and restricted to the late-third-instar fat body tissue. In a previous study we showed that the -68 to -138 region relative to the transcription start site acts as an ecdysone-dependent third-instar fat body-specific enhancer in a transgenic assay. Here we report that seven nucleoprotein complexes are formed in vitro on this enhancer when a nuclear extract from late-third-instar fat body is used in a gel shift assay. Accurate mapping of the binding sites of the complexes revealed a r

APA, Harvard, Vancouver, ISO, and other styles

20

Berra, Marta, Emma L. Williams, Barbara Muroni та ін. "Recognition of 5α-reductase-2 deficiency in an adult female 46XY DSD clinic". European Journal of Endocrinology 164, № 6 (2011): 1019–25. http://dx.doi.org/10.1530/eje-10-0930.

Full text

Abstract:

ContextThe late presentation of steroid 5α-reductase-2 (SRD5A2) deficiency in females is poorly characterised. The ratios of 5α/5β-reduced metabolites of adrenal steroids in a urine steroid profile (USP) can give an indication of SRD5A2 deficiency, although the diagnostic cut-off for 5α/5β ratios are not clearly defined in genetically confirmed cases.ObjectiveThe aim of this study was to establish the frequency of SRD5A2 deficiency in an adult clinic for disorders of sexual development (DSD) focussing on 46XY partially virilised adult female subjects. We investigated the relationship between U

APA, Harvard, Vancouver, ISO, and other styles

21

Dela Cruz, FE, DR Kirsch, and JN Heinrich. "Transcriptional activity of Drosophila melanogaster ecdysone receptor isoforms and ultraspiracle in Saccharomyces cerevisiae." Journal of Molecular Endocrinology 24, no. 2 (2000): 183–91. http://dx.doi.org/10.1677/jme.0.0240183.

Full text

Abstract:

The Drosophila melanogaster ecdysone receptor (EcR) is produced in three isoforms, which mediate developmental processes such as metamorphosis. These isoforms were expressed in Saccharomyces cerevisiae to elucidate aspects of receptor transcription activity in a highly defined genetic model system. All three EcR isoforms showed ligand-independent transcriptional activation of an ecdysone reporter gene and the amount of activation correlated with the size of the N-terminal A/B (transactivation) domain present in the isoform: EcR-B1>EcR-A>>EcR-B2. Upon co-expression with ultraspiracle (

APA, Harvard, Vancouver, ISO, and other styles

22

Murali, Preethi, B. Kavitha, and Malathi Narasimhan. "Overexpression of deubiquitinase (usp 36) in oral squamous cell carcinoma." Journal of Oral and Maxillofacial Pathology 27, no. 4 (2023): 623–28. http://dx.doi.org/10.4103/jomfp.jomfp_311_23.

Full text

Abstract:

Aim: Oral cancer is one of the top three types of cancer and is of significant public health importance in India. A common post-translational modification in cells is ubiquitination/deubiquitination, and its dysregulation is closely associated with the development of cancer. Studies on the role of ubiquitination in oral squamous cell carcinoma (OSCC) are lacking. Increased expression of usp36 has been observed in various types of cancer, and this study aimed to check the gene expression of usp36 in OSCC patients. In this study, we analyzed the expression of ubiquitin-specific proteases (USPs)

APA, Harvard, Vancouver, ISO, and other styles

23

Nachin, Laurence, Ulf Nannmark, and Thomas Nyström. "Differential Roles of the Universal Stress Proteins of Escherichia coli in Oxidative Stress Resistance, Adhesion, and Motility." Journal of Bacteriology 187, no. 18 (2005): 6265–72. http://dx.doi.org/10.1128/jb.187.18.6265-6272.2005.

Full text

Abstract:

ABSTRACT The universal stress protein (UspA) superfamily encompasses a conserved group of proteins that are found in bacteria, archaea, and eukaryotes. Escherichia coli harbors six usp genes—uspA, -C, -D, -E, -F, and -G—the expression of which is triggered by a large variety of environmental insults. The uspA gene is important for survival during cellular growth arrest, but the exact physiological role of the Usp proteins is not known. In this work we have performed phenotypic characterization of mutants with deletions of the six different usp genes. We report on hitherto unknown functions of

APA, Harvard, Vancouver, ISO, and other styles

24

Bakkar, Mohamad, Sara Khalil, Komal Bhayekar, et al. "Ubiquitin-Specific Protease Inhibitors for Cancer Therapy: Recent Advances and Future Prospects." Biomolecules 15, no. 2 (2025): 240. https://doi.org/10.3390/biom15020240.

Full text

Abstract:

Cancer management has traditionally depended on chemotherapy as the mainstay of treatment; however, recent advancements in targeted therapies and immunotherapies have offered new options. Ubiquitin-specific proteases (USPs) have emerged as promising therapeutic targets in cancer treatment due to their crucial roles in regulating protein homeostasis and various essential cellular processes. This review covers the following: (1) the structural and functional characteristics of USPs, highlighting their involvement in key cancer-related pathways, and (2) the discovery, chemical structures, mechani

APA, Harvard, Vancouver, ISO, and other styles

25

Zhang, Yan, Kui-Ting Ding, Nian-Wan Yang, et al. "Juvenile Hormone and Ecdysteroids Facilitate the Adult Reproduction Through the Methoprene-Tolerant Gene and Ecdysone Receptor Gene in the Female Spodoptera frugiperda." International Journal of Molecular Sciences 26, no. 5 (2025): 1914. https://doi.org/10.3390/ijms26051914.

Full text

Abstract:

Insects, as the most diverse and numerous group in the animal kingdom, are at least partly dependent on the reproduction process, which is strictly regulated by the ‘classic’ insect hormones: juvenile hormone (JH), and 20-hydroxyecdysone (20E). However, the regulatory mechanism governing the reproduction of JH and 20E in Spodoptera frugiperda remains unclear. In this study, ovarian development and ovulation in female S. frugiperda were assessed through dissection of the ovaries following treatment with JH analog (JHA) and 20E. Moreover, the expression patterns of the JH-signal and 20E-signal-r

APA, Harvard, Vancouver, ISO, and other styles

26

Antoniewski, C., B. Mugat, F. Delbac, and J. A. Lepesant. "Direct repeats bind the EcR/USP receptor and mediate ecdysteroid responses in Drosophila melanogaster." Molecular and Cellular Biology 16, no. 6 (1996): 2977–86. http://dx.doi.org/10.1128/mcb.16.6.2977.

Full text

Abstract:

The steroid hormone 20-hydroxyecdysone plays a key role in the induction and modulation of morphogenetic events throughout Drosophila development. Previous studies have shown that a heterodimeric nuclear receptor composed of the EcR and USP proteins mediates the action of the hormone at the transcriptional through binding to palindromic ecdysteroid mediates the action of the hormone at the transcriptional level through binding to palindromic ecdysteroid response elements (EcREs) such as those present in the promoter of the hsp27 gene or the fat body-specific enhancer of the Fbp1 gene. We show

APA, Harvard, Vancouver, ISO, and other styles

27

Xu, Tao, Tianchi Chen, Tianye Zhang, et al. "Genome-Wide Identification and Characterization of USP Gene Family in Grapes (Vitis vinifera L.)." Horticulturae 8, no. 11 (2022): 1024. http://dx.doi.org/10.3390/horticulturae8111024.

Full text

Abstract:

With the frequent occurrence of extreme natural disasters, unfavorable growth environment is a common phenomenon in the life cycle of plants. In recent years, universal stress proteins (USPs) have attracted extensive attention in the field of plant science for their expression patterns and functional analysis. However, the characterization of the USP family remains unclear in grape. In this study, we identified 30 VvUSPs in the grape genome, which could be divided into three classes according to their encoded protein sequences, and this classification was reflected by the distribution of conse

APA, Harvard, Vancouver, ISO, and other styles

28

Perrimon, Norbert, Lee Engstrom, and Anthony P. Mahowald. "DEVELOPMENTAL GENETICS OF THE 2C-D REGION OF THE DROSOPHILA X CHROMOSOME." Genetics 111, no. 1 (1985): 23–41. http://dx.doi.org/10.1093/genetics/111.1.23.

Full text

Abstract:

ABSTRACT We have conducted a genetic and developmental analysis of genes within the 2C-D area of the X chromosome. Phenotypes of 33 mutations representing nine adjacent complementation groups including eight recessive lethals and one visible homeotic mutation (polyhomeotic) are described. Germline clonal analysis of the eight zygotic lethals has revealed three types of gene requirements: (1) normal activity at two pupal lethal loci (corkscrew and C204) and one larval lethal locus (ultraspiracle) is required for normal embryogenesis; (2) normal activity at three larval lethal loci (DF967, VE651

APA, Harvard, Vancouver, ISO, and other styles

29

Boes, Nelli, Kerstin Schreiber, and Max Schobert. "SpoT-Triggered Stringent Response Controls usp Gene Expression in Pseudomonas aeruginosa." Journal of Bacteriology 190, no. 21 (2008): 7189–99. http://dx.doi.org/10.1128/jb.00600-08.

Full text

Abstract:

ABSTRACT The universal stress proteins (Usps) UspK (PA3309) and UspN (PA4352) of Pseudomonas aeruginosa are essential for surviving specific anaerobic energy stress conditions such as pyruvate fermentation and anaerobic stationary phase. Expression of the respective genes is under the control of the oxygen-sensing regulator Anr. In this study we investigated the regulation of uspN and three additional P. aeruginosa usp genes: uspL (PA1789), uspM (PA4328), and uspO (PA5027). Anr induces expression of these genes in response to anaerobic conditions. Using promoter-lacZ fusions, we showed that P

APA, Harvard, Vancouver, ISO, and other styles

30

Zhou, Ting, Mingxia Fan, Muhammad Irfan, et al. "Phylogenetic analysis of STK gene family and Usp domain in maize." Molecular Biology Reports 41, no. 12 (2014): 8273–84. http://dx.doi.org/10.1007/s11033-014-3728-y.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Rijavec, Matija, Manca Müller-Premru, Breda Zakotnik, and Darja Žgur-Bertok. "Virulence factors and biofilm production among Escherichia coli strains causing bacteraemia of urinary tract origin." Journal of Medical Microbiology 57, no. 11 (2008): 1329–34. http://dx.doi.org/10.1099/jmm.0.2008/002543-0.

Full text

Abstract:

The aim of the present study was to gain an insight into the role of virulence determinants and biofilm production in bacteraemia of urinary tract origin. For this purpose 105 Escherichia coli isolates from patients with bacteraemia of urinary tract origin, isolated at the Institute of Microbiology and Immunology, University of Ljubljana, Slovenia, were investigated. A total of 88 strains (84 %) were isolated from immunocompromised patients and 17 (16 %) from non-immunocompromised patients. The prevalence of virulence factor (VF)-encoding genes and associations with phylogenetic background, an

APA, Harvard, Vancouver, ISO, and other styles

32

Rusin, A., A. Niedziela-Majka, G. Rymarczyk, and A. Ozyhar. "Expression and purification of 6xHis-tagged DNA binding domains of functional ecdysteroid receptor from drosophila melanogaster." Acta Biochimica Polonica 43, no. 4 (1996): 611–21. http://dx.doi.org/10.18388/abp.1996_4457.

Full text

Abstract:

Two members of the nuclear receptor superfamily, EcR and Ultraspiracle (Usp) heterodimerize to form a functional receptor for 20-hydroxyecdysone-the key ecdysteroid controlling induction and modulation of morphogenetic events through Drosophila development. In order to study aspects of receptor function and ultimately the structural basis of the ecdysteroid receptor-DNA interaction, it is necessary to produce large quantities of purified EcR and Usp DNA-binding domains. Toward this end, we have expressed the EcR DNA-binding domain and the Usp DNA-binding domain as proteins with an affinity tag

APA, Harvard, Vancouver, ISO, and other styles

33

CHEN, JINRU. "uspA of Shigella sonnei." Journal of Food Protection 70, no. 10 (2007): 2392–95. http://dx.doi.org/10.4315/0362-028x-70.10.2392.

Full text

Abstract:

One of the strategies that bacteria utilize to combat environmental stress is to synthesize stress-responding proteins. In Escherichia coli, adverse environmental factors, such as starvation, heat, and the presence of acid, oxidants, heavy metals, and antibiotics, trigger the expression of the universal stress protein (USP). The gene of the USP, uspA, in E. coli K-12 and E. coli O157:H7 has been identified and sequenced. In this study, the nucleotide sequence of uspA in a strain of Shigella sonnei implicated in the 1998 parsley-related outbreak of shigellosis was determined. Within an 800-bp r

APA, Harvard, Vancouver, ISO, and other styles

34

Dabbah, Roger. "Ancillary Products for Cell and Gene Therapy and Tissue Engineering: USP Initiative." BioProcessing Journal 3, no. 4 (2004): 21–22. http://dx.doi.org/10.12665/j34.dabbah.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Wang, Yizhi, Dongkai Zhou, Yang Kong, Qifan Yang, Yuan Ding, and Weilin Wang. "USPs in Pancreatic Ductal Adenocarcinoma: A Comprehensive Bioinformatic Analysis of Expression, Prognostic Significance, and Immune Infiltration." BioMed Research International 2022 (December 20, 2022): 1–21. http://dx.doi.org/10.1155/2022/6109052.

Full text

Abstract:

Pancreatic ductal adenocarcinoma (PDAC), as an intractable malignancy, still causes an extremely high mortality worldwide. The ubiquitin-specific protease (USP) family constitutes the major part of deubiquitinating enzymes (DUBs) which has been reported to be involved in initiation and progression of various malignancies via the function of deubiquitination. However, the biological function and clinical values of USPs in PDAC have not been comprehensively elucidated. In this study, Gene Expression Profiling Interactive Analysis (GEPIA), Gene Expression Omnibus (GEO) datasets, UALCAN database,

APA, Harvard, Vancouver, ISO, and other styles

36

Vengatharajuloo, Vinothienii, Hoe-Han Goh, Maizom Hassan, et al. "Gene Co-Expression Network Analysis Reveals Key Regulatory Genes in Metisa plana Hormone Pathways." Insects 14, no. 6 (2023): 503. http://dx.doi.org/10.3390/insects14060503.

Full text

Abstract:

Metisa plana Walker (Lepidoptera: Psychidae) is a major oil palm pest species distributed across Southeast Asia. M. plana outbreaks are regarded as serious ongoing threats to the oil palm industry due to their ability to significantly reduce fruit yield and subsequent productivity. Currently, conventional pesticide overuses may harm non-target organisms and severely pollute the environment. This study aims to identify key regulatory genes involved in hormone pathways during the third instar larvae stage of M. plana gene co-expression network analysis. A weighted gene co-expression network anal

APA, Harvard, Vancouver, ISO, and other styles

37

Boes, Nelli, Kerstin Schreiber, Elisabeth Härtig, Lothar Jaensch, and Max Schobert. "The Pseudomonas aeruginosa Universal Stress Protein PA4352 Is Essential for Surviving Anaerobic Energy Stress." Journal of Bacteriology 188, no. 18 (2006): 6529–38. http://dx.doi.org/10.1128/jb.00308-06.

Full text

Abstract:

ABSTRACT During infection of the cystic fibrosis (CF) lung, Pseudomonas aeruginosa microcolonies are embedded in the anaerobic CF mucus. This anaerobic environment seems to contribute to the formation of more robust P. aeruginosa biofilms and to an increased antibiotic tolerance and therefore promotes persistent infection. This study characterizes the P. aeruginosa protein PA4352, which is important for survival under anaerobic energy stress conditions. PA4352 belongs to the universal stress protein (Usp) superfamily and harbors two Usp domains in tandem. In Escherichia coli, Usp-type stress p

APA, Harvard, Vancouver, ISO, and other styles

38

Isokpehi, Raphael D., Shaneka S. Simmons, Hari H. P. Cohly, Stephen I. N. Ekunwe, Gregorio B. Begonia, and Wellington K. Ayensu. "Identification of Drought-Responsive Universal Stress Proteins in Viridiplantae." Bioinformatics and Biology Insights 5 (January 2011): BBI.S6061. http://dx.doi.org/10.4137/bbi.s6061.

Full text

Abstract:

Genes encoding proteins that contain the universal stress protein (USP) domain are known to provide bacteria, archaea, fungi, protozoa, and plants with the ability to respond to a plethora of environmental stresses. Specifically in plants, drought tolerance is a desirable phenotype. However, limited focused and organized functional genomic datasets exist on drought-responsive plant USP genes to facilitate their characterization. The overall objective of the investigation was to identify diverse plant universal stress proteins and Expressed Sequence Tags (ESTs) responsive to water-deficit stres

APA, Harvard, Vancouver, ISO, and other styles

39

Wang, Sheng-Fu, Stephen Ayer, William A. Segraves, Daryl R. Williams, and Alexander S. Raikhel. "Molecular Determinants of Differential Ligand Sensitivities of Insect Ecdysteroid Receptors." Molecular and Cellular Biology 20, no. 11 (2000): 3870–79. http://dx.doi.org/10.1128/mcb.20.11.3870-3879.2000.

Full text

Abstract:

ABSTRACT The functional receptor for insect ecdysteroid hormones is a heterodimer consisting of two nuclear hormone receptors, ecdysteroid receptor (EcR) and the retinoid X receptor homologue Ultraspiracle (USP). Although ecdysone is commonly thought to be a hormone precursor and 20-hydroxyecdysone (20E), the physiologically active steroid, little is known about the relative activity of ecdysteroids in various arthropods. As a step toward characterization of potential differential ligand recognition, we have analyzed the activities of various ecdysteroids using gel mobility shift assays and tr

APA, Harvard, Vancouver, ISO, and other styles

40

Seaver, S. "A new United States Pharmacopeia (USP) Chapter 1046: Cell and Gene Therapy Products." Cytotherapy 2, no. 1 (2000): 45–49. http://dx.doi.org/10.1080/146532400539044.

Full text

APA, Harvard, Vancouver, ISO, and other styles

41

Henrich, Vincent C., A. Alex Szekely, Se Jae Kim, et al. "Expression and Function of the ultraspiracle (usp) Gene during Development of Drosophila melanogaster." Developmental Biology 165, no. 1 (1994): 38–52. http://dx.doi.org/10.1006/dbio.1994.1232.

Full text

APA, Harvard, Vancouver, ISO, and other styles

42

Li, Jingjing, Letong Yin, Jingxiu Bi, David Stanley, Qili Feng та Qisheng Song. "The TGF-β Receptor Gene Saxophone Influences Larval-Pupal-Adult Development in Tribolium Castaneum". Molecules 27, № 18 (2022): 6017. http://dx.doi.org/10.3390/molecules27186017.

Full text

Abstract:

The transforming growth factor-β (TGF-β) superfamily encodes a large group of proteins, including TGF-β isoforms, bone morphogenetic proteins and activins that act through conserved cell-surface receptors and signaling co-receptors. TGF-β signaling in insects controls physiological events, including growth, development, diapause, caste determination and metamorphosis. In this study, we used the red flour beetle, Tribolium castaneum, as a model species to investigate the role of the type I TGF-β receptor, saxophone (Sax), in mediating development. Developmental and tissue-specific expression pr

APA, Harvard, Vancouver, ISO, and other styles

43

Przibilla, S., W. W. Hitchcock, M. Szécsi, et al. "Functional studies on the ligand-binding domain of Ultraspiracle from Drosophila melanogaster." Biological Chemistry 385, no. 1 (2004): 21–30. http://dx.doi.org/10.1515/bc.2004.004.

Full text

Abstract:

AbstractThe functional insect ecdysteroid receptor is comprised of the ecdysone receptor (EcR) and Ultraspiracle (USP). The ligand-binding domain (LBD) of USP was fused to the GAL4 DNA-binding domain (GAL4-DBD) and characterized by analyzing the effect of site-directed mutations in the LBD. Normal and mutant proteins were tested for ligand and DNA binding, dimerization, and their ability to induce gene expression. The presence of helix 12 proved to be essential for DNA binding and was necessary to confer efficient ecdysteroid binding to the heterodimer with the EcR (LBD), but did not influence

APA, Harvard, Vancouver, ISO, and other styles

44

Urso, Maria L., Angus G. Scrimgeour, Yi-Wen Chen, Paul D. Thompson, and Priscilla M. Clarkson. "Analysis of human skeletal muscle after 48 h immobilization reveals alterations in mRNA and protein for extracellular matrix components." Journal of Applied Physiology 101, no. 4 (2006): 1136–48. http://dx.doi.org/10.1152/japplphysiol.00180.2006.

Full text

Abstract:

We examined the effects of 48 h of knee immobilization on alterations in mRNA and protein in human skeletal muscle. We hypothesized that 48 h of immobilization would increase gene expression and respective protein products for ubiquitin-proteasome pathway (UPP) components. Also, we used microarray analysis to identify novel pathways. Biopsies were taken from the vastus muscle of five men (20.4 ± 0.5 yr) before and after 48-h immobilization. Global changes in gene expression were analyzed by use of Affymetrix GeneChips. Candidate genes were confirmed via quantitative RT-PCR. Western blotting (W

APA, Harvard, Vancouver, ISO, and other styles

45

Diao, Jian, Wei Gu, Zhehui Jiang, et al. "Comprehensive Analysis of Universal Stress Protein Family Genes and Their Expression in Fusarium oxysporum Response of Populus davidiana × P. alba var. pyramidalis Louche Based on the Transcriptome." International Journal of Molecular Sciences 24, no. 6 (2023): 5405. http://dx.doi.org/10.3390/ijms24065405.

Full text

Abstract:

Universal stress proteins (USPs) are typical stress-inducible proteins that function directly in a variety of biotic or abiotic stresses and effectively protect plants from complex, adverse environments. However, the expression patterns of USP genes under pathogen stress and their molecular mechanisms in stress resistance have not been reported in detail. In this study, 46 USP genes were identified from Populus trichocarpa (PtrUSPs), and their biological characteristics were comprehensively analyzed based on phylogeny, physicochemical properties of proteins, and gene structures. The promoter r

APA, Harvard, Vancouver, ISO, and other styles

46

Schreiber, Kerstin, Nelli Boes, Martin Eschbach, et al. "Anaerobic Survival of Pseudomonas aeruginosa by Pyruvate Fermentation Requires an Usp-Type Stress Protein." Journal of Bacteriology 188, no. 2 (2006): 659–68. http://dx.doi.org/10.1128/jb.188.2.659-668.2006.

Full text

Abstract:

ABSTRACT Recently, we identified a pyruvate fermentation pathway in Pseudomonas aeruginosa sustaining anaerobic survival in the absence of alternative anaerobic respiratory and fermentative energy generation systems (M. Eschbach, K. Schreiber, K. Trunk, J. Buer, D. Jahn, and M. Schobert, J. Bacteriol. 186:4596-4604, 2004). Anaerobic long-term survival of P. aeruginosa might be essential for survival in deeper layers of a biofilm and the persistent infection of anaerobic mucus plaques in the cystic fibrosis lung. Proteome analysis of P. aeruginosa cells during a 7-day period of pyruvate ferment

APA, Harvard, Vancouver, ISO, and other styles

47

Hennebry, Jennifer, Douglas Mulholland, Nairi Tchrakian, et al. "Nodular fasciitis: A pseudomalignant clonal neoplasm characterized by USP gene rearrangements and spontaneous regression." International Journal of Case Reports and Images 8, no. 01 (2017): 80. http://dx.doi.org/10.5348/ijcri-201713-cr-10752.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Auhim, Husam Sabah, and Hassan Majeed Rasheed. "Distribution and association of an usp genotoxin gene with biofilm formation in E. coli." Microbial Biosystems 10, no. 2 (2025): 0. https://doi.org/10.21608/mb.2025.352629.1228.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Pianovski, Mara Albonei Dudeque, and Bonald Cavalcante de Figueiredo. "Mutação R337H no gene TP53, frequente no Sul e Sudeste do Brasil, não parece ser suficiente como causa de câncer em crianças e adultos." Revista Brasileira de Cancerologia 63, no. 3 (2019): 219–21. http://dx.doi.org/10.32635/2176-9745.rbc.2017v63n3.144.

Full text

Abstract:

Nesta Edição Temática da “História do Controle do Câncer no Brasil”, registramos o progresso alcançado até o momento no entendimento epidemiológico e vigilância dos tumores adrenocorticais (TCA ) no Estado do Paraná. Esses resultados foram apresentados no Congresso deEndocrinologia Pediátrica realizado em Curitiba, no ano de 2000, e um ano mais tarde, por meio da publicação do mesmo grupo3, confirmada por endocrinologistas da Universidade de São Paulo (USP)4.

APA, Harvard, Vancouver, ISO, and other styles

50

Luo, Dan, Zilin Wu, Qian Bai, et al. "Universal Stress Proteins: From Gene to Function." International Journal of Molecular Sciences 24, no. 5 (2023): 4725. http://dx.doi.org/10.3390/ijms24054725.

Full text

Abstract:

Universal stress proteins (USPs) exist across a wide range of species and are vital for survival under stressful conditions. Due to the increasingly harsh global environmental conditions, it is increasingly important to study the role of USPs in achieving stress tolerance. This review discusses the role of USPs in organisms from three aspects: (1) organisms generally have multiple USP genes that play specific roles at different developmental periods of the organism, and, due to their ubiquity, USPs can be used as an important indicator to study species evolution; (2) a comparison of the struct

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!