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Dissertations / Theses on the topic 'Valproic acid therapeutic use'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Conceição, Erika Christina Gouveia da. "Análise observacional de aquisições motoras em crianças portadoras de Amiotrofia Espinal Tipo I submetidas à intervenção medicamentosa com ácido valpróico." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-04082008-111025/.

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A amiotrofia espinal (AEP) é a mais freqüente das doenças neuromusculares (DNM) responsáveis pela Síndrome da Criança Hipotônica (SCH), causada pela degeneração das células do corno anterior da medula espinhal. O comprometimento neurológico se estabelece de forma rápida e intensa nos primeiros meses de vida de tal maneira que, em pouco tempo, a única atividade motora voluntária persistente pode ser a motricidade ocular. O Ácido Valpróico é um medicamento de fácil aquisição e administração, demonstrou-se eficaz em evitar a deleção do exon 7, o que prolongaria ainda mais a sobrevivência dos neur

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2

Pawlish, Gerald Joseph. "TAILORING DRUG-CARRIER INTERACTIONS IN POLY(SIALIC ACID) MICELLES FOR USE AS CANCER THERAPEUTIC CARRIERS." Diss., Temple University Libraries, 2018. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/519673.

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Bioengineering<br>Ph.D.<br>Although great progress has been made, cancer still remains one of the most prevalent maladies plaguing mankind. New treatment methodologies using nanoparticles have come to the forefront by allowing for enhanced delivery of therapeutics to the tumor site. The design of the nanoparticle should allow for long circulation times, tumor-specific targeting and efficient release at the site of action. This requires that both the external shell and internal core of the nanoparticle be carefully selected to meet the maximal criteria of each of these steps. Poly(sialic acid)

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3

Mohamad, Bustaman Ahmad Fahmi. "The effectiveness of intra-articular hyaluronic acid in temporomandibular disorders." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44661150.

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4

Liang, Wanling, and 梁婉玲. "Formulation of nucleic acid with pH-responsive amphipathic peptides for pulmonary delivery." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/207996.

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5

Jetson, Rachael Rene. "Design and Development of Potential Therapeutic Agents for Use in Hormone Responsive Cancers." University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1384270219.

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6

Potter, Kathleen. "The effects of long-term homocysteine-lowering treatment with folic acid, vitamin B6 and Vitamin B12 on vascular structure and function in stroke." University of Western Australia. School of Medicine and Pharmacology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0020.

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[Truncated abstract] An elevated total plasma homocysteine concentration (tHcy) is associated with an increased risk of myocardial infarction and ischemic stroke. Folic acid, vitamin B6 and B12 supplements significantly reduce tHcy even in people who are not overtly vitamin deficient. If homocysteine is a causal risk factor for atherothrombotic events, treatment with B-vitamins might prove a simple and cost-effective means to reduce cardiovascular risk. However, it remains unclear whether elevated tHcy causes atherosclerosis or is simply a risk marker. To prove that homocysteine is a modifiabl

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7

Xie, Lixia. "Effects of salvianolic acid B against apoptosis and adhesion molecules expression in the vascular endothelial cells." HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1082.

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8

Péraudeau, Elodie. "Évaluation et optimisation de l'efficacité de conjugués anticancéreux ciblant les récepteurs de l'acide folique." Thesis, Poitiers, 2016. http://www.theses.fr/2016POIT2309/document.

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En dépit des progrès réalisés ces dernières décennies, le cancer demeure un problème majeur de santé publique. La plupart des chimiothérapies conventionnelles exploitent les propriétés cytotoxiques d'agents non sélectifs qui affectent les cellules à division rapide, qu'elles soient cancéreuses ou non, ce qui peut aboutir à une toxicité importante et de sévères effets secondaires. Pour pallier à ce problème, l'utilisation de ligands de ciblage pour délivrer spécifiquement l'agent cytotoxique aux cellules malignes tout en épargnant les tissus sains est une approche prometteuse. Parmi les différe

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9

Müller, Adrienne Carmel. "An investigation into the neuroprotective properties of acyclovir." Thesis, Rhodes University, 2006. http://hdl.handle.net/10962/d1003254.

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Accumulating evidence suggests that quinolinic acid has a role to play in disorders involving impairment of learning and memory. In the present study, the effect of the guanosine analogue antiherpetic, acyclovir, on quinolinic acid-induced spatial memory deficits was investigated, as well as some of the mechanisms which underlie this effect. Behavioural studies using a Morris water maze show that post-treatment of rats with acyclovir significantly improves spatial memory deficits induced by intrahippocampal injections of quinolinic acid. Histological analysis of the hippocampi show that the ef

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10

Xu, Zheyang (Kevin). "Pomegranate flower ameliorates fatty liver in an animal model of type 2 diabetes and obesity : upregulation of hepatic expression of genes responsible for fatty acid oxidation." Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28956.

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Pomegranate flower (PGF) has been prescribed in Unani and Ayurvedic medicines for the treatment of diabetes. It has been demonstrated that PGF extract activates peroxisome proliferator-activated receptor (PPAR) -or and -y to improve glucose tolerance, hyperlipidemia and excess cardiac triglyceride (TG) accumulation in Zucker diabetic fatty (ZDF) rats. Fatty liver (hepatic steatosis), the most common cause of abnormal liver function tests, is strongly associated with insulin resistance. The effect and its underlying mechanism of PGF on fatty liver was investigated in ZDF rats and in huma

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11

Demasi, Maryanne. "The effects of hypoxia on cyclooxygenase-2 expression and eicosanoid synthesis /." Title page, table of contents and summary only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phd3729.pdf.

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Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine and Royal Adelaide Hospital, Rheumatology Unit, 2004.<br>Includes list of publications arising from this thesis. Erratum attached to inside back cover. "25/03/2004." Includes bibliographical references (leaves 185-257).

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12

Vesna, Vasić. "Folna kiselina u terapiji depresivnog poremećaja." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2014. http://www.cris.uns.ac.rs/record.jsf?recordId=87827&source=NDLTD&language=en.

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Cilj ovog istraživanja je bio da se utvrdi nivo folne kiseline u serumu (fiziolo&scaron;ka vrednost je od 16,31 do 34,88 nmol/l) i proceni težina kliničke slike instrumentima kliničke procene (HAMD 17 i 21, MADRS i CGI skala) u populaciji bolnički lečenih pacijenata, koji boluju od te&scaron;ke depresivne epizode, ili rekurententog depresivnog poremećaja, i njihov odgovor na inicijalnu antidepresivnu terapiju sprovođenu prema smernicama nacionalnog vodiča. Odgovor na antidepresivnu terapiju je određivan nakon četiri i osam nedelja lečenja u odnosu na nivo folne kiseline i prema nadoknadi folne

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13

Du, Toit Joe-Lin. "The modulation of various signal transduction pathways in colorectal carcinoma cells by docosahexaenoic acid." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/17350.

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Thesis (MSc)--University of Stellenbosch, 2006.<br>ENGLISH ABSTRACT: Introduction: The ability of different polyunsaturated fatty acids (PUFAs), especially n-3 PUFAs, to prevent the development of cancer has been under intense investigation the past three decades. Numerous studies have shown that these fatty acids can kill cancer cells in vitro as well as in vivo whilst normal cells remain unaffected. Unfortunately, the cellular and molecular mechanisms responsible for this phenomenon are still poorly understood. This study investigated the signalling pathways modulated by docosahexaenoi

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14

Hawkes, Joanna Susan. "N-3 fatty acids, eicosanoids and control of inflammation /." Title page, contents and summary only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phh392.pdf.

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Thesis (Ph. D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, and Rheumatology Unit, Royal Adelaide Hospital, 1994.<br>Errata slip inserted. Includes bibliographical references (leaves 178-199).

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15

Haddad, Alessandra [UNIFESP]. "Luz intensa pulsada e ácido 5 aminolevulínico no tratamento de queratoses actínicas e fotoenvelhecimento facial." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9790.

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Made available in DSpace on 2015-07-22T20:50:24Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-04-28<br>INTRODUÇÃO: Rejuvenescimento fotodinâmico refere-se ao tratamento do fotoenvelhecimento e das queratoses actínicas. OBJETIVO: Avaliar a eficácia da terapia fotodinâmica com ácido aminolevulínico a 20% (ALA) ¾ tópico e luz intensa pulsada no tratamento das queratoses actínicas e do fotoenvelhecimento facial. MÉTODOS: Quarenta e três pacientes com idade média 71,3 anos, fototipos de pele I e IV divididos em: Controle (aplicação LIP/18J); Tratamento-I (ALA incubado por duas horas; at

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16

Furlan, Carla Barbosa Muraro. "O impacto de reúso de dialisadores nos marcadores de estresse oxidativo e inflamatórios em pacientes em hemodiálise." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5148/tde-09062014-101133/.

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A morbimortalidade dos pacientes em hemodiálise permanece alta apesar da evolução tecnológica do procedimento, sendo que os eventos cardiovasculares são a sua principal causa. Estes desencadeados pela alta prevalência de fatores de risco tradicionais, fatores relacionados ao procedimento dialítico e estresse oxidativo. Considerando o procedimento dialítico e o estresse oxidativo, foi avaliado o quanto a habitual prática de reuso de dialisadores/RD (difundida nas Américas e amparada principalmente por questões econômicas) e uso único de dialisadores, influenciam nos marcadores inflamatórios e d

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17

Meski, Ana Paula Gomes. "Estudo comparativo da pele pré- e pós-quimioabrasão para tratamento de rítides da região perioral: avaliação clínica e imuno-histoquímica." Universidade de São Paulo, 2005. http://www.teses.usp.br/teses/disponiveis/5/5133/tde-19032007-093446/.

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Atualmente existem vários tratamentos para melhorar a aparência da pele com fotoenvelhecimento. A quimioabrasão é uma dessas técnicas, consiste na associação de esfoliação química com ácido tricloroacético a 35%, seguida por dermabrasão. O ácido tricloroacético facilita a dermabrasão por promover coagulação das proteínas da pele, tornando-a mais friável. Além disto, produz um branqueamento na pele que está relacionado ao seu grau de penetração, auxiliando a uniformização da profundidade atingida com a dermabrasão. A técnica de dermabrasão utilizada neste estudo, foi manual com lixas d?água, po

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18

Refifi, Jihen. "Extraction de la silice à partir d'un composé H₂SiF₆ pour la fabrication d'un bioverre." Thesis, Rennes 1, 2020. http://www.theses.fr/2020REN1S066.

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L'acide fluorosilicique (FSA) est la principale eau usée générée par la fabrication d'acide phosphorique en Tunisie. Actuellement, Une énorme quantité de cet acide est générée comme sous-produit de l'industrie des engrais phosphatés. En plus des pertes économiques, le rejet de cette industrie dans la mer, entraine également un véritable danger dans le cadre écologique pour le domaine marin. Par conséquent, notre attention s'est portée sur le développement d'un procédé de traitement par extraction de la silice de ces déchets fluorés, qui peut être utilisée dans plusieurs applications intéressan

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19

Wang, Hsin-Hui, and 王馨慧. "Evaluation of therapeutic effect of valproic acid in polyglutamine-expanded cell and animal models." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/77622933757810065060.

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碩士<br>國立臺灣師範大學<br>生命科學研究所<br>95<br>Autosomal dominant spinocerebellar ataxias (SCAs) are a clinically and genetically heterogeneous group of neurodegenerative disorders primarily affecting the cerebellum. Valproic acid (VPA) has been reported as an effective molecule in neurodegenerative disease models such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) mouse models. In vitro studies have also shown that VPA can reduce polyglutamine (polyQ) toxicity and suppress neuron death. Considering these studies, it is possible to ameliorate symptoms of polyQ-mediated SCAs throu

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20

Deveau, Adam. "USING A TRANSGENIC ZEBRAFISH MODEL TO IDENTIFY DOWNSTREAM THERAPEUTIC TARGETS IN HIGH-RISK, NUP98-HOXA9-INDUCED MYELOID DISEASE." 2013. http://hdl.handle.net/10222/36250.

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Acute myeloid leukemia (AML) is a genetic disease whereby sequential genetic aberrations alter essential white blood cell development leading to differentiation arrest and hyperproliferation. Pertinent animal models serve as essential intermediaries between in vitro molecular studies and the use of new agents in clinical trials. We previously generated a transgenic zebrafish model expressing human NUP98-HOXA9 (NHA9), a fusion oncogene found in high-risk AML. This expression yields a pre-leukemic state in both embryos and adults. Using this model, we have identified the overexpression of dnmt1

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"Effects of nicotinic acid with laropiprant in Chinese patients with dyslipidaemia: phenotypic and genotypic determinants." 2013. http://library.cuhk.edu.hk/record=b5884289.

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Yang, Yaling.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 187-207).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstracts also in Chinese.

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22

Farelo, Mafalda de Arrábida. "The role of KDAC inhibitors in nitrogen metabolism: the therapeutic challenges for liver disease and hepatocelular carcinoma." Master's thesis, 2015. http://hdl.handle.net/10451/25010.

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Tese de mestrado, Ciências Biofarmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2015<br>Lysine deacetylases inhibitors (KDACi) are compounds that interfere with the activity of Lysine deacetylases, enzymes that mediate removal of acetyl groups from protein lysine residues. Modulation of acetylation status may alter the activity of many proteins of intermediary metabolism. KDACi became promising drugs for cancer therapy, where valproic acid (VPA) is one example. VPA is associated with mitochondrial dysfunction, although its multifactorial effects still need further research, especia

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"Growth inhibitory effect of docosahexaenoic acid on human melanoma A375 cells." 2007. http://library.cuhk.edu.hk/record=b5896766.

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Tong, Kit Fong.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 91-104).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Acknowledgements --- p.vi<br>Table of Contents --- p.vii<br>List of Figures --- p.x<br>List of Tables --- p.xii<br>List of Abbreviations --- p.xiii<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Cancer --- p.2<br>Chapter 1.1.1 --- Tumor development --- p.2<br>Chapter 1.1.2 --- Cell cycle --- p.4<br>Chapter 1.1.3 --- Apoptosis --- p.9<br>Chapter 1.1.3.1 --- The extrinsic pathwa

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"Studies on the anti-tumor activities of conjugated linolenic acid on human neuroblastoma cells." 2009. http://library.cuhk.edu.hk/record=b5894102.

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Ho, Lai Ying.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2009.<br>Includes bibliographical references (leaves 213-238).<br>Abstract also in Chinese.<br>Abstract --- p.i<br>Abstract in Chinese (摘要） --- p.iv<br>Acknowledgements --- p.vii<br>List of abbreviations --- p.ix<br>Table of contents --- p.xiv<br>Chapter Chapter One: --- General Introduction_ --- p.1<br>Chapter 1.1 --- Neuroblastoma --- p.2<br>Chapter 1.1.1 --- An overview on neuroblastoma --- p.2<br>Chapter 1.1.2 --- Classification of neuroblastoma --- p.4<br>Chapter 1.1.3 --- Epidemiology of neuroblastoma --- p.7<b

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"Modulatory effects of conjugated linolenic acid (CLN) on the proliferation and apoptosis of human myeloid leukemia cells." 2007. http://library.cuhk.edu.hk/record=b5896735.

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Yip, Wai Ki.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.<br>Includes bibliographical references (leaves 203-228).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGMENTS --- p.i<br>ABBREVIATIONS --- p.iii<br>ABSTRACT --- p.x<br>撮要 --- p.xiv<br>TABLE OF CONTENTS --- p.xvii<br>Chapter CHAPTER 1: --- GENERAL INTRODUCTION<br>Chapter 1.1 --- Hematopoiesis and Leukemia<br>Chapter 1.1.1 --- An Overview on Hematopoiesis Development --- p.1<br>Chapter 1.1.1.1 --- Hematopoietic Growth Factors --- p.4<br>Chapter 1.1.1.2 --- Site Switching of Hematopoiesis --- p.5<br>Chapter 1.1.2

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"The antioxidant and hypolipidemic effect of conjugated linoleic acid (CLA)." 1999. http://library.cuhk.edu.hk/record=b5890145.

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Yeung Chi Hang, Thomas.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1999.<br>Includes bibliographical references (leaves 126-146).<br>Abstracts in English and Chinese.<br>Table of content<br>ACKNOWLEDGEMENT --- p.i<br>ABSTRACT --- p.ii<br>LIST OF ABBREVIATION --- p.vi<br>TABLE OF CONTENTS --- p.vii<br>Chapter Chapter1 --- General Introduction<br>Chapter 1.1 --- INTRODUCTION --- p.1<br>Chapter 1.2 --- FORMATION OF CLA --- p.1<br>Chapter 1.3 --- OCCURRENCE OF CLA IN FOODS --- p.5<br>Chapter 1.4 --- PHYSIOLOGICAL EFFECTS OF CLA --- p.8<br>Chapter 1.4.1 --- Anticarcinogenic Effec

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Jiang, Zhi-dong. "Novel oxylipins and heterocycles from the Rhodophyta and Cyanophyta." Thesis, 1992. http://hdl.handle.net/1957/36329.

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Baier, Jennie Melinda. "Hyaluronic acid hydrogel biomaterials for soft tissue engineering applications." Thesis, 2003. http://wwwlib.umi.com/cr/utexas/fullcit?p3116256.

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"Studies on the anti-tumor activity of conjugated linoleic acid against myeloid leukemia." 2005. http://library.cuhk.edu.hk/record=b5892533.

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Lui Oi Lan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves [216]-240).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGEMENTS --- p.i<br>ABBREVIATIONS --- p.ii<br>ABSTRACT --- p.vii<br>撮要 --- p.x<br>PUBLICATIONS --- p.xiii<br>TABLE OF CONTENTS --- p.xiv<br>Chapter CHAPTER 1: --- GENERAL INTRODUCTION<br>Chapter 1.1 --- Hematopoiesis and Leukemia --- p.1<br>Chapter 1.1.1 --- An Overview on Hematopoietic Development --- p.1<br>Chapter 1.1.2 --- Leukemia --- p.8<br>Chapter 1.1.2.1 --- General Diagnostic Tests for Leukemia ---

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"Towards regeneration: hyaluronan, a modulator of cutaneous wound healing." Thesis, 2009. http://library.cuhk.edu.hk/record=b6074800.

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HA (Hyaluronan, hyaluronic acid) is a predominant component of the extracellular matrix and plays diverse roles in the process of wound healing. The major significance of the biological functions of HA in wound healing arise from early studies showing that rich and prolonged existence of HA is associated with the fetal scarless wound healing. It has been hypothesized that adult wound healing can be modulated by the application of exogenous HA to make the process of wound repair more like regeneration.<br>In this thesis, the effects of molecular weight and concentration of HA on the biological

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Dillard, Alice Clare. "The mechanism by which retinol decreases β-catenin protein in retinoic acid-resistant colon cancer cells". Thesis, 2007. http://hdl.handle.net/2152/3028.

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Kavimandan, Nikhil Jayant. "In vitro and in vivo behavior of insulin delivery systems based on poly(ethylene glycol)-grafted poly(methacrylic acid) hydrogels." Thesis, 2005. http://hdl.handle.net/2152/1588.

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"Induction and modulation of apoptosis in pancreatic cancer cells by eicosapentaenoic acid and the expression of a novel marker of apoptosis." 1998. http://library.cuhk.edu.hk/record=b6073122.

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by Lai Bo San Paul.<br>"April 1997."<br>"Revised May 1998."<br>Thesis (M.D.)--Chinese University of Hong Kong, 1998.<br>Includes bibliographical references (p. 175-228).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstract in Chinese.

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"Effect of ascorbic acid on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced toxicity in the brain of balb/c mouse." 2004. http://library.cuhk.edu.hk/record=b6073677.

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by Chan Tak Yee Bonita.<br>"July 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 121-137).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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"The anti-cancer activities of paeoniae radix extracts on human hepatocellular carcinoma cell-line HepG2 and multidrug resistant human hepatocellular carcinoma cell-line R-HepG2 and their action mechanisms." 2004. http://library.cuhk.edu.hk/record=b6073630.

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Li Lok Yee Mandy.<br>"June 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 155-165).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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"Development of an immunoassay for tartrate-resistant acid phosphatase and its use in the monitoring of bone metabolism." Chinese University of Hong Kong, 1993. http://library.cuhk.edu.hk/record=b5887784.

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Chi Keung Cheung.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1993.<br>Includes bibliographical references (leaves 219-251).<br>Chapter CHAPTER I --- LITERATURE REVIEW<br>Chapter 1 --- The structure of bone --- p.2<br>Chapter 1.1. --- The cortical bone --- p.3<br>Chapter 1.2. --- The cancellous bone --- p.3<br>Chapter 2 --- The composition of bone --- p.3<br>Chapter 2.1. --- Bone minerals --- p.4<br>Chapter 2.2. --- The organic matrix --- p.4<br>Chapter 2.3. --- The bone cells --- p.9<br>Chapter 2.3.1. --- The osteoblast and the osteocyte --- p.9<br>Chapter 2.3.2. --- The osteo

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Dlamini, Immaculate Nonkululeko. "Effects of plants-derived oleanolic acid in an in-vitro model hyperglycaemia-induced oxidative stress." Thesis, 2010. http://hdl.handle.net/10413/5894.

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Diabetes mellitus (DM) has become a global threat in developing and developed countries, where diabetic patients are more prone to cardiovascular complications, a condition called diabetic cardiomyopathy. Studies have shown a direct link between hyperglycaemia and an increase in the production of reactive oxygen species in cardiac cells leading to diabetic cardiomyopathy. This study tests oleanolic acid, a bioactive compound from the plant Syzigium aromaticum as an antioxidant which could have a potential role in management of DM. Aims i) To extract Oleanolic acid (OA) from Syzigium aromaticim

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Wang, Xinyu 1974 Aug 12. "Amelioration of oxidative stress in human endothelial cells by caffeic acid phenethyl ester (CAPE) and fluorinated derivatives (FCAPES) and pharmacokinetic characterization of CAPE and FCAPE in rats." Thesis, 2007. http://hdl.handle.net/2152/3716.

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Tissue ischemia is a major cause of morbidity contributing to disease processes such as cardiovascular diseases, stroke, cancer, and traumatic injury and may lead to death. Failure to quickly reestablish flow to ischemic tissue results in tissue death. However, even timely return to normal flow has a downside in that the reintroduction of oxygen to ischemic tissue results in ischemia/reperfusion (I/R) injury that produces an oxidant stress. This pathological process requires new therapeutic strategies and agents to reduce the personal, social and economic loss. One of the most generally accept

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Moghaddam, Mehran Fallah. "Structural and biosynthetic studies on marine eicosanoids and other oxylipins." Thesis, 1991. http://hdl.handle.net/1957/36535.

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Machado, André da Costa. "Utilização terapêutica de ácido valpróico e sua quantificação em fluidos biológicos." Master's thesis, 2019. http://hdl.handle.net/10284/7685.

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A epilepsia é uma patologia que afeta o sistema nervoso, caracterizada pela recorrência de crises epiléticas espontâneas (não provocadas). Esta condição condiciona diretamente a qualidade de vida do indivíduo afetado, com consequências neurobiológicas, cognitivas e sociais. Atualmente existem mais de cinquenta milhões de pessoas em todo o mundo a sofrer de epilepsia, sendo que cerca de um terço destas não demonstra uma resposta satisfatória a nenhuma das opções terapêuticas disponíveis. O tratamento desta doença centra-se na administração de fármacos antiepiléticos, os quais devem ser escolhi

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Barney, Jason Phillip 1975. "An in-vitro study evaluating the efficacy of the ultrasonic bypass system™, using different intracanal irrigating solutions." Thesis, 2010. http://hdl.handle.net/1805/2225.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>This in-vitro, prospective, randomized study microscopically compared the debridement efficacy of passive ultrasonic irrigation (PUI) using the Ultrasonic Bypass System and different irrigating protocols. Eighty extracted maxillary anterior teeth were randomly assigned to four groups. Teeth were instrumented using EndoSequence rotary instrument system and treated with passive ultrasonic irrigation with different irrigating regimens for one minute. Group one (control) was treated with hand/rotary instrumentation. Group two was treate

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"Anti-tumor effect of Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid in mouse models of liver cancer and lung cancer". 2009. http://library.cuhk.edu.hk/record=b5896562.

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Leung, Jackie.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2009.<br>Includes bibliographical references (leaves 117-131).<br>Abstract also in Chinese.<br>Abstract --- p.i<br>論文摘要 --- p.iii<br>Acknowledgement --- p.iv<br>List of publications --- p.vi<br>List of Tables --- p.vi<br>List of Figures --- p.vi<br>Table of Contents --- p.ix<br>Chapter Chapter 1: --- Introduction --- p.1<br>Chapter 1.1. --- Liver cancer --- p.1<br>Chapter 1.1.1. --- Hepatocellular Carcinoma (HCC) --- p.2<br>Chapter 1.2. --- Lung Cancer --- p.5<br>Chapter 1.3. --- Pteris semipinnata L --- p.8<br>Ch

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"Effects of IL-27 and uric acid crystal on the activation of fibroblast-like synoviocytes, and the anti-inflammatory activities of sinomenine and liang miao san on TNF-α-activated fibroblast-like synoviocytes in rheumatoid arthritis". Thesis, 2011. http://library.cuhk.edu.hk/record=b6075144.

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Besides the molecular mechanisms regulating activation of FLS mentioned above, we also investigated anti-inflammatory activities of Chinese herbal medicine sinomenine and Liang Miao San on activated human FLS in RA. Sinomenine, an alkaloid isolated from the root of Sinomenium acutum, has been used to alleviate the symptoms of rheumatic diseases. Liang Miao San (LMS), composed of the herbs Rhizoma Atractylodis (Cangzhu) and Cotex Phellodendri (Huangbai), is another traditional Chinese medicine formula for RA treatment. Since the potential anti-inflammatory activities of sinomenine and LMS have

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Kayoka-Kabongo, Prudence Ngalula. "Characterization of mycobacteria SPP. and antimycobacterial activities of plant derived compounds from Anacardiaceae family." Thesis, 2016. http://hdl.handle.net/10500/22719.

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The treatment of tuberculosis (TB) is currently a challenge due to multi- and extensively drug resistant strains of Mycobacterium tuberculosis. Mycobacterium bovis and M. tuberculosis cause clinically indistinguishable tuberculosis in humans. Both M. bovis and M. tuberculosis have been isolated from humans and animals. Plant species contain antimicrobial compounds that may lead to new anti-TB drugs. To conduct in vitro antimycobacterial assays, it is important to include current clinical isolates as new strains of bacteria might be circulating under the ongoing climate change environment. The

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Botha, Lynette Elizabeth. "Investigating the production of secondary metabolites effective in lowering blood glucose levels in Euclea Undulata Thunb. Var Myrtina (Ebenaceae)." Diss., 2016. http://hdl.handle.net/10500/21927.

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Euclea undulata Thunb. var myrtina is a widely distributed shrub in South Africa. The roots are used by traditional healers for the treatment of diabetes. Research indicates that roots contain epicatechin, lupeol as well α-amyrin-3O-β-(5-hydroxy) ferulic acid. It was found that α-amyrin-3O-β-(5-hydroxy) ferulic acid inhibits α-glucosidase while epicatechin lowers glucose levels in the blood. Existing literature also indicates the presence of the naphthoquinone 7-methyl-juglone in the roots, although it was not detected in all cases. Due to its cytotoxic nature, 7-methyl-juglone poses a potenti

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