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Journal articles on the topic 'Valproic acid therapeutic use'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Bruserud, Øystein, Galina Tsykunova, Maria Hernandez-Valladares, Hakon Reikvam, and Tor Henrik Anderson Tvedt. "Therapeutic Use of Valproic Acid and All-Trans Retinoic Acid in Acute Myeloid Leukemia—Literature Review and Discussion of Possible Use in Relapse after Allogeneic Stem Cell Transplantation." Pharmaceuticals 14, no. 5 (2021): 423. http://dx.doi.org/10.3390/ph14050423.

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Even though allogeneic stem cell transplantation is the most intensive treatment for acute myeloid leukemia (AML), chemo-resistant leukemia relapse is still one of the most common causes of death for these patients, as is transplant-related mortality, i.e., graft versus host disease, infections, and organ damage. These relapse patients are not always candidates for additional intensive therapy or re-transplantation, and many of them have decreased quality of life and shortened expected survival. The efficiency of azacitidine for treatment of posttransplant AML relapse has been documented in se

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Gelbard, Amos. "Valproic Acid in Parkinson's Disease: A Friend or Foe?" British Journal of Healthcare & Medical Research 12, no. 03 (2025): 238–40. https://doi.org/10.14738/bjhr.1203.18873.

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There have been several reports of Parkinson's disease like symptoms being a side effect of Valproic Acid use. Valproic Acid is a drug prescribed for Epileptic seizures and also as a mood stabilizer. Despite the said reports of Parkinson's like side effects, several other studies had shown it to in fact be neuroprotective and perhaps therapeutic against PD in vivo. This review will center around these few studies, bring their results and ask for more experimentation to solve this issue of whether Valproic Acid triggers Parkinson's or perhaps triggers a healing from it. I would hypothesize in t

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Vázquez, Marta, Pietro Fagiolino, Cecilia Maldonado, et al. "Hyperammonemia Associated with Valproic Acid Concentrations." BioMed Research International 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/217269.

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Valproic acid, a branched short-chain fatty acid, has numerous action mechanisms which turn it into a broad spectrum anticonvulsant drug and make its use possible in some other pathologies such as bipolar disorder. It is extensively metabolized in liver, representingβ-oxidation in the mitochondria one of its main metabolic route (40%). Carnitine is responsible for its entry into the mitochondria as any other fatty acid. Long-term high-dose VPA therapy or acute VPA overdose induces carnitine depletion, resulting in high levels of ammonia in blood. As a high correlation between salivary valproic

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Sari, Dini Permata, and Winda Septyani Sianipar. "Pemantauan Kadar Obat Antiepilepsi dalam Darah terhadap Clinical Outcome pada Pasien Epilepsi di RSPAD Gatot Soebroto dengan Pendekatan Farmakokinetika." Pharmaceutical and Biomedical Sciences Journal (PBSJ) 6, no. 2 (2024): 124–35. https://doi.org/10.15408/pbsj.v6i2.38924.

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The use of antiepileptic drugs requires monitoring of blood drug levels because antiepileptics are drugs with a narrow therapeutic index. This study was conducted to determine the relationship between the accuracy of blood antiepileptic drug levels and clinical outcomes in epilepsy patients at RSPAD Gatot Soebroto using a pharmacokinetic approach. This study is an analytical observational study with a retrospective cross-sectional study of epilepsy patients using antiepileptic drugs from January 2023 to January 2024 at RSPAD Gatot Soebroto Jakarta. The results of this study showed that the mos

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Rasiani, Salma. "The impact of valproic acid administration: Effects on the growth of tongue cancer cells." Asian Journal of Toxicology, Environmental, and Occupational Health 2, no. 1 (2024): 13–26. http://dx.doi.org/10.61511/ajteoh.v2i1.2024.939.

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Background: Tongue cancer represents the predominant malignancy within the oral cavity (25-40% of squamous cell carcinoma), necessitating treatment modalities such as surgery, radiotherapy, and chemotherapy. Valproic acid, an antiepileptic medication, functions as a histone deacetylase inhibitor or activator of anti-tumor signaling pathways. Objective: To deepen our understanding of the effects of valproic acid on the viability, cytotoxicity, proliferation, and migration capabilities of HSC-3 cells. Method: This study employed an in vitro laboratory approach, exposing HSC-3 cells to valproic a

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Bidzan, Leszek. "USE OF VALPROIC ACID FOR THE TREATMENT OF NEUROPSYCHIATRIC SYMPTOMS IN ACQUIRED BRAIN INJURIES." Acta Neuropsychologica 18, no. 3 (2020): 357–66. http://dx.doi.org/10.5604/01.3001.0014.3876.

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Acquired brain injuries are often accompanied by a series of neuropsychiatric disorders. A wide range of pharmacological agents are used to treat neuropsychiatric symptoms. However, a more indepth review of the agents used indicates that there are in fact relatively few procedures recommended for use. Anticonvulsants including valproic acid, are of particular interest. This research aimed to assess the efficacy and safety of valproic acid, as based on a naturalistic observation of patients with various forms of acquired brain injury and who had displayed neuropsychiatric symptoms. The study gr

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Yee, Jennie L., David Wong, and Thomas M. Ormiston. "Encephalopathy and Hyperammonemia Associated with Valproic Acid." Journal of Pharmacy Technology 21, no. 6 (2005): 348–50. http://dx.doi.org/10.1177/875512250502100607.

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Objective: To discuss the case of a patient who experienced an altered level of consciousness secondary to hyperammonemia associated with valproic acid who had normal drug concentrations and liver function tests. Case Summary: A 48-year-old man with a history of seizure disorder treated with valproic acid presented with an altered level of consciousness. An extensive workup revealed only an increased ammonia level. His medications were withheld. Within 24 hours, the ammonia level returned to normal and he was able to be aroused. His antiseizure medication was changed to gabapentin. All of his

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Chateauvieux, Sébastien, Franck Morceau, Mario Dicato, and Marc Diederich. "Molecular and Therapeutic Potential and Toxicity of Valproic Acid." Journal of Biomedicine and Biotechnology 2010 (2010): 1–18. http://dx.doi.org/10.1155/2010/479364.

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Valproic acid (VPA), a branched short-chain fatty acid, is widely used as an antiepileptic drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of Gamma Amino Butyrate (GABA) transaminobutyrate and of ion channels. VPA was recently classified among the Histone Deacetylase Inhibitors, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. VPA is a widely used drug, particularly for children suffering from epilepsy. Due to the increasing number of clinical trials involving VPA, and

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Memon, Madeeha, Chetan Das, Shazia, Ayesha Almas, Shahjan, and Touseef. "FREQUENCY OF VALPROIC INDUCED THROMBOCYTOPENIA AND SERUM VALPROIC ACID LEVEL IN EPILEPTIC PATIENTS PRESENTING AT CIVIL HOSPITAL (LUMHS), HYDERABAD." Insights-Journal of Health and Rehabilitation 3, no. 2 (Health & Rehab) (2025): 109–15. https://doi.org/10.71000/ha45ba86.

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Background: Valproic acid is a widely prescribed broad-spectrum antiepileptic drug used in the management of various seizure disorders. Despite its efficacy, its use is associated with multiple adverse effects, including thrombocytopenia, which can increase the risk of bleeding complications. The identification and monitoring of valproic acid-induced thrombocytopenia are essential to ensuring safe and effective treatment. However, limited local data exist on the prevalence of this adverse effect, necessitating further investigation to establish appropriate monitoring and management strategies

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Boonlue, Tuanthon, Papitchaya Sitsuer, Wasinee Phosri, and Warisara Jinatongthai. "Factors associated with subtherapeutic levels of valproic acid in hospitalized patients with epilepsy: A retrospective cohort study." Medicine 103, no. 45 (2024): e40488. http://dx.doi.org/10.1097/md.0000000000040488.

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Valproic acid (VPA) is a commonly used anti-seizure medication, owing to its efficacy and cost-effectiveness. However, maintaining appropriate serum levels is crucial due to the narrow therapeutic window, as subtherapeutic levels can lead to treatment failure or adverse outcomes. This study aimed to identify the factors associated with subtherapeutic serum levels of valproic acid in patients undergoing treatment. This retrospective cohort study was performed at a tertiary care hospital and involved inpatients aged ≥ 18 years who were receiving valproic acid for epilepsy treatment. Data were ob

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Alvarez, Vincent, Jean-Marie Januel, Bernard Burnand, and Andrea O. Rossetti. "Second-line status epilepticus treatment: comparison of phenytoin, valproate, and levetiracetam." Epilepsia 52, no. 7 (2011): 1292–96. https://doi.org/10.1111/j.1528-1167.2011.03056.x.

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PURPOSE: Phenytoin (PHT), valproic acid (VPA), or levetiracetam (LEV) are commonly used as second-line treatment of status epilepticus (SE), but comparative studies are not available. METHODS: Among 279 adult SE episodes identified prospectively in our tertiary care hospital over 4 years, we retrospectively identified 187 episodes in which PHT, VPA, or LEV were given after benzodiazepines. Patients with postanoxic SE were not included. Demographics, clinical SE features, failure of second-line treatment to control SE, new handicap, and mortality at hospital discharge were assessed. Uni- and mu

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Al-Quteimat, Osama, and Alla Laila. "Valproate Interaction With Carbapenems: Review and Recommendations." Hospital Pharmacy 55, no. 3 (2019): 181–87. http://dx.doi.org/10.1177/0018578719831974.

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Introduction: Valproic acid is a commonly used antiepileptic drug. Combining valproate derivatives with carbapenem antibiotics is associated with a potential drug interaction that decreases serum concentration of valproate and may expose the patient to uncontrolled seizure risk from valproate subtherapeutic concentration. Raising awareness of this drug interaction among health care providers including emergency department physicians, neurologists, and pharmacists is highly needed. The aim of this article was to review the current literature about the potential drug interaction resulting from c

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Schönfeldt-Lecuona, C., B. J. Connemann, R. W. Freudenmann, C. Hiemke, and M. M. Schmid. "Liver failure under valproic acid." European Psychiatry 26, S2 (2011): 1282. http://dx.doi.org/10.1016/s0924-9338(11)72987-x.

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Valproic acid (VPA, 2-propylvaleric acid) is originally an antiepileptic drug, which has been in use for more than 30 years in over 100 countries. The clinical application of VPA has expanded in the last years. Approval has been granted by the FDA for treatment of migraine and cluster headache in 1996, and for treatment of mania and long-term prophylaxis of bipolar affective disorder in 1995. In ongoing studies, VPA has been reported to inhibit growth of several types of cancer cells; in addition, effects on neurodegeneration, and on virus replication in HIV infection have been demonstrated po

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Suryoputri, Masita W., Nialiana E. Endriastuti, and Dewi L. Ilma. "Effects of Antiepileptic Drug Levels on Clinical Outcomes in Pediatric Patients Using Pharmacokinetics Approach." Indonesian Journal of Clinical Pharmacy 10, no. 4 (2021): 272–88. http://dx.doi.org/10.15416/ijcp.2021.10.4.272.

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The high prevalence of antiepileptic drug use in pediatrics increases the risk of side and toxic effects; therefore, it is necessary to monitor drug levels. Therapeutic drug monitoring is conducted through pharmacokinetics by calculating blood drug levels based on respondents' dose and frequency of therapy. This study aimed to determine the pharmacokinetics of antiepileptic drug levels and the correlation with clinical outcomes using descriptive observational design. Furthermore, the Indonesian Epilepsy Community collected respondents' data from June to July 2020 through online and telephone i

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Guest, Ian, Harpal S. Buttar, Susan Smith, and Daya R. Varma. "Evaluation of the rat embryo culture system as a predictive test for human teratogens." Canadian Journal of Physiology and Pharmacology 72, no. 1 (1994): 57–62. http://dx.doi.org/10.1139/y94-010.

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Ingestion of the anticonvulsant drag valproic acid and of the angiotensin converting enzyme inhibitor captopril during pregnancy has been associated with abnormal fetal outcome in humans. In contrast, the use of the antiinflammatory drug ibuprofen and the antihistamine diphenhydramine has not been documented to be embryotoxic in humans. We evaluated the rat embryo culture system as a predictive model of teratogenesis, using these four drugs as test agents. Valproic acid, ibuprofen, and diphenhydramine were embryotoxic, inducing concentration-dependent decreases in growth and a significant incr

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Kozlovsky, V. L., and A. S. Zbrodina. "Valproic acid: historical background and prospects for use in urgent psychiatric practice." Medical alphabet, no. 2 (March 28, 2025): 52–55. https://doi.org/10.33667/2078-5631-2025-2-52-55.

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The expansion of indications for the use of valproic acid (VK) has been noted since the end of the 20th century. On the one hand, this is due to the pharmacodynamics of the drug and the favorable profile of its clinical action, and on the other hand, the emergence of modern dosage forms that determine the ease of use. By analogy with carbamazepine, the therapeutic activity of VK began to be studied in mental disorders. Along with the thymostabilizing effect similar to lithium, VK began to be used for the treatment of not only affective fluctuations, but also for the prevention of secondary exa

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Moses H., Mugo. "Exploring the Therapeutic Potential of Valproic Acid in the Management of Diabetes Mellitus." IDOSR JOURNAL OF SCIENTIFIC RESEARCH 9, no. 3 (2024): 54–59. http://dx.doi.org/10.59298/idosrjsr/2024/9.3.545900.

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Diabetes mellitus, encompassing Type 1 (T1DM) and Type 2 Diabetes Mellitus (T2DM), represents a significant global health challenge characterized by chronic hyperglycemia resulting from insulin dysfunction. This review explores the therapeutic potential of Valproic Acid (VPA), traditionally used in epilepsy and mood disorders, in managing diabetes. VPA has demonstrated various beneficial effects, including the protection of pancreatic β-cells from apoptosis, enhancement of insulin sensitivity, and modulation of glucose and lipid metabolism. Preclinical studies indicate VPA’s capability to impr

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Louro de Hollanda, Marcos, João Pedro do Valle Varela, Maria Victória Bahia Silva, et al. "VALPROIC ACID INTERFERENCE IN ABDOMINAL WALL TISSUE REPAIR." Health and Society 5, no. 03 (2025): 74–84. https://doi.org/10.51249/hs.v5i03.2543.

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Valproic acid (AVP) is widely used in the treatment of epilepsy and mood disorders, but recent studies suggest that its epigenetic action may negatively interfere in tissue regeneration and healing processes. Repair of the abdominal wall, essential for the success of procedures such as herniorrhaphy and laparotomy, depends on a cascade of inflammatory, cellular and molecular events that can be modulated by systemic drugs such as AVP. The aim of this study was to analyze the interference of valproic acid in abdominal wall healing, considering its possible effects on collagen synthesis, fibrobla

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Sanivarapu, Raghavendra, Robin Sharma, and Jagadish Akella. "Thinking out of the box: management of valproic acid toxicity with carbapenems." BMJ Case Reports 14, no. 3 (2021): e240140. http://dx.doi.org/10.1136/bcr-2020-240140.

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Valproic acid (VPA) is commonly used medication to treat seizure disorder and as prophylaxis for bipolar disorder. Acute VPA toxicity can cause varied symptoms ranging from mild drowsiness to severe cerebral oedema and coma. The therapeutic level of VPA is around 50–100 µg/mL and most of it is protein bound. It is mainly metabolised by liver and is eliminated via bile. The metabolites of VPA interfere with urea cycle and cause deficiency in carnitine leading to increase in ammonia levels. The use of carnitine to treat VPA toxicity is well known but it is still unclear if it lowers VPA levels.

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Mishra, Manish Kumar, Samiksha Kukal, Priyanka Rani Paul, et al. "Insights into Structural Modifications of Valproic Acid and Their Pharmacological Profile." Molecules 27, no. 1 (2021): 104. http://dx.doi.org/10.3390/molecules27010104.

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Valproic acid (VPA) is a well-established anticonvulsant drug discovered serendipitously and marketed for the treatment of epilepsy, migraine, bipolar disorder and neuropathic pain. Apart from this, VPA has potential therapeutic applications in other central nervous system (CNS) disorders and in various cancer types. Since the discovery of its anticonvulsant activity, substantial efforts have been made to develop structural analogues and derivatives in an attempt to increase potency and decrease adverse side effects, the most significant being teratogenicity and hepatotoxicity. Most of these c

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Subbiah, Ishwaria Mohan, Vivek Subbiah, Aung Naing, et al. "Targeted therapies in early-phase trials for the treatment of advanced fibrolamellar hepatocellular carcinoma." Journal of Clinical Oncology 31, no. 4_suppl (2013): 232. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.232.

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232 Background: Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare primary liver malignancy, affecting young adults w/o chronic liver disease. Limited data exists on the novel therapeutics for this disease. Methods: Given its rarity, we evaluated the characteristics, outcomes and performed molecular analysis for targetable pathways in patients with FLHCC enrolled on phase I trials with an emphasis on targeted therapies. Results: Ten FLHCC patients (8 female, 2 male; median age 23yrs) were evaluated in the Phase I Clinic. Eight had recurrence from prior resections. Eight patients enrolled

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Rinaldi, Victoria Elisa, Giuseppe Di Cara, Elisabetta Mencaroni, and Alberto Verrotti. "Therapeutic Options for Childhood Absence Epilepsy." Pediatric Reports 13, no. 4 (2021): 658–67. http://dx.doi.org/10.3390/pediatric13040078.

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Childhood absence epilepsy (CAE) is a common pediatric generalized epileptic syndrome. Although it is traditionally considered as a benign self-limited condition, the apparent benign nature of this syndrome has been revaluated in recent years. This is mainly due to the increasing evidence that children with CAE can present invalidating neuropsychological comorbidities that will affect them up to adulthood. Moreover, a percentage of affected children can develop drug-resistant forms of CAE. The purpose of this review is to summarize the most recent studies and new concepts concerning CAE treatm

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Grynkiv, Ia O., O. B. Blavatska, and O. M. Zalis'ka. "Cost analysis of epilepsy pharmacotherapy by valproic acid and carbamazepine." Farmatsevtychnyi zhurnal, no. 2 (August 14, 2018): 21–29. http://dx.doi.org/10.32352/0367-3057.2.17.03.

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The prevalence of epilepsy in Ukraine in 2009 was 68.7, and the incidence – 5.7 per 100 thousand population. According to statistics in 2014, the incidence of epilepsy in Lviv region was 19.0 patients per 100 thousand population. The purpose of research was to process information about the prices for medicines based on valproic acid and carbamazepine of different manufacturers in different dosages and release forms in drugstores Lviv by searching service «GeoApteka». The object of investigation was the information from the site «State Register of Medical Products of Ukraine», prici

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Zierath, Dannielle, Stephanie Mizuno, and Melissa Barker-Haliski. "Frontline Sodium Channel-Blocking Antiseizure Medicine Use Promotes Future Onset of Drug-Resistant Chronic Seizures." International Journal of Molecular Sciences 24, no. 5 (2023): 4848. http://dx.doi.org/10.3390/ijms24054848.

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The mechanisms of treatment-resistant epilepsy remain unclear. We have previously shown that frontline administration of therapeutic doses of lamotrigine (LTG), which preferentially inhibits the fast-inactivation state of sodium channels, during corneal kindling of mice promotes cross-resistance to several other antiseizure medicines (ASMs). However, whether this phenomenon extends to monotherapy with ASMs that stabilize the slow inactivation state of sodium channels is unknown. Therefore, this study assessed whether lacosamide (LCM) monotherapy during corneal kindling would promote future dev

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El, Fellah Sara, Imane Adali, and Fatiha Manoudi. "Balancing the mind: The critical role of carbamazepine as a mood stabilizer in bipolar and schizoaffective disorders." World Journal of Advanced Research and Reviews 22, no. 2 (2024): 1063–66. https://doi.org/10.5281/zenodo.14607732.

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This case study explores the therapeutic application and associated challenges of using carbamazepine as a mood stabilizer in the management of schizoaffective disorder. The patient, a 42-year-old male with a history of schizoaffective disorder, exhibited acute manic symptoms exacerbated by substance use and non-compliance with medication. The introduction of carbamazepine initially showed promise in stabilizing mood and reducing psychotic symptoms. However, the treatment course was complicated by a significant adverse dermatological reaction. This necessitated a switch to valproic acid, which

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Boone, Dayany Leonel, Emanuelle Ferreira Barreto, Felipe Sales Parreira, Henrique Carneiro de Campos, and Lucas Roquim e. Silva. "Warfarin in the treatment of refractory chronic cluster headache: a case report and review in therapeutic options." Headache Medicine 13, no. 2 (2022): 133–36. http://dx.doi.org/10.48208/headachemed.2022.9.

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Cluster headache is the most common of trigeminal autonomic cephalalgia, with variable prevalence. It can be episodic or chronic, with few remission and high therapeutic failure. The case refers to a 55-year-old female patient, hypertensive and diabetic, with a history of migraine without aura with pain management. In 2014, the patient began to present a new headache pattern, with a diagnosis of Chronic Cluster Headache. Pain management to nasal sumatriptan as an acute treatment. For the prophylactic treatment, she presented therapeutic failure to several medications, with pain management with

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Makbul, Firshan, and Ardhi Rahman Ahani. "Assessing the Potential of Valproic Acid as an Adjuvant Agent among Various Histological Subtypes of Thyroid Cancer: A Systematic Review." Indonesian Journal of Cancer 18, no. 4 (2024): 507–16. https://doi.org/10.33371/ijoc.v18i4.1169.

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Background: Valproic acid (VPA) has gained attention as an anticonvulsant drug with potential anti-cancer effects, including in thyroid cancer. It hampers the viability of cancer cells by blocking their cell cycle progression, specifically in the G1 or sub-G1 phases. However, the clinical role of VPA as an adjuvant agent, in addition to the thyroid cancer primary treatment, remains an area of investigation.Methods: We conducted a comprehensive systematic literature review from the first publication available to July 2021. We comprised clinical trials and preclinical investigations that explore

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Watson, Amanda, Pankil Shah, Doug Lee, et al. "Valproic acid use is associated with diminished risk of contracting COVID-19, and diminished disease severity: Epidemiologic and in vitro analysis reveal mechanistic insights." PLOS ONE 19, no. 8 (2024): e0307154. http://dx.doi.org/10.1371/journal.pone.0307154.

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The SARS-CoV-2 pandemic has caused unprecedented worldwide infections from persistent mutant variants with various degrees of infectivity and virulence. The elusiveness of a highly penetrant, worldwide vaccination strategy suggests that the complete eradication of SARS-CoV-2 is unlikely. Even with the advent of new antiviral agents, the disease burden worldwide continues to exceed current preventative and therapeutic strategies. Greater interest has been placed towards the development of affordable,broadly effective antiviral therapeutics. Here, we report that the small branched-chain fatty ac

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El Fellah Sara, Adali Imane, and Manoudi Fatiha. "Balancing the mind: The critical role of carbamazepine as a mood stabilizer in bipolar and schizoaffective disorders." World Journal of Advanced Research and Reviews 22, no. 2 (2024): 1063–66. http://dx.doi.org/10.30574/wjarr.2024.22.2.1328.

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This case study explores the therapeutic application and associated challenges of using carbamazepine as a mood stabilizer in the management of schizoaffective disorder. The patient, a 42-year-old male with a history of schizoaffective disorder, exhibited acute manic symptoms exacerbated by substance use and non-compliance with medication. The introduction of carbamazepine initially showed promise in stabilizing mood and reducing psychotic symptoms. However, the treatment course was complicated by a significant adverse dermatological reaction. This necessitated a switch to valproic acid, which

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Gupta, Varun, Kanchan Gupta, Gagandeep Singh, and Sandeep Kaushal. "An Analytical Study to Correlate Serum Levels of Levetiracetam with Clinical Course in Patients with Epilepsy." Journal of Neurosciences in Rural Practice 07, S 01 (2016): S031—S036. http://dx.doi.org/10.4103/0976-3147.196445.

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ABSTRACT Introduction: With the advancement of therapeutics, newer antiepileptic drugs (AEDs) like Levetiracetam (LEV), with good therapeutic efficacy and tolerability are available. But unfortunately, therapeutic drug monitoring is not routinely done in India for these drugs. Objectives: The objective of this study is to determine the range of serum levels of LEV in patients at stabilized doses and correlate them with their clinical course. Materials and Methods: Patients with epilepsy and started on LEV were enrolled from the Neurology Department after the Ethics Committee approval. Serum le

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Abid, Momina, FNU javairia, and Abdul Basit. "The Valproic Acid Dilemma: Safe Alternatives for Pregnant Women and women of childbearing age with Epilepsy." Journal of the Pakistan Medical Association 73, no. 11 (2023): 2302. http://dx.doi.org/10.47391/jpma.10077.

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Madam, Valproic acid is a widely used anticonvulsant medication that exerts its therapeutic effects by increasing GABA activity in the brain, making it a first-line therapy for focal and generalized seizures. However, despite its efficacy, the medication is associated with significant adverse effects in pregnant or childbearing-age women, with teratogenicity being the most severe outcome. A Study1 published in Italy raised some serious concerns regarding prenatal exposure to valproic acid, which can affect the prenatal and postnatal intellectual development of the newborn, and the use of alter

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Riiter Muller, Isadora, Lilian de Lima Feltraco Lizot, and Rafael Linden. "METHOD VALIDATION FOR QUANTIFICATION OF CARBAMAZEPINE AND VALPROIC ACID IN CAPILLARY BLOOD COLLECTED BY ONEDRAW." Perspectivas em medicina legal e pericias medicas 7, no. 1 (2022): e221223. http://dx.doi.org/10.47005/221223.

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Introduction: Individuals undergoing treatment for epilepsy may have difficulty adhering to treatment. Among the reasons, forgetfulness and adverse effects caused by medication can be highlighted. With this scenario, it is understood that there is a need to carry out therapeutic monitoring of patients undergoing treatment for epilepsy. The OneDraw device, which allows you to obtain a capillary blood sample from its fixation in the upper part of the arm, eliminates some of the obstacles encountered in collecting capillary blood by the finger, such as pain, discomfort and waiting time. Material

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Podolská, K., D. Mazánková, and M. Göböová. "Retrospective Assessment of the Use of Pharmacotherapeutic Agents in Pregnancy with Potential Impact on Neonatal Health." European Pharmaceutical Journal 69, no. 2 (2022): 17–25. http://dx.doi.org/10.2478/afpuc-2022-0015.

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Abstract This study focuses on the role of a clinical pharmacist in the optimisation of pharmacotherapy in the case of patients during pregnancy and its importance within the hospital sector in Slovakia. Retrospective evaluation of pharmacotherapy in pregnant patients with a focus on teratogenicity and appropriate drug selection was used. The hospital data were collected during 24 months from 22 female patients. The main observed outcome was health condition of the newborn, and it was expressed as healthy newborn, illness of the newborn, any congenital defect or malformation, spontaneous abort

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Charlier, Bruno, Albino Coglianese, Federica De Rosa, et al. "The Effect of Plasma Protein Binding on the Therapeutic Monitoring of Antiseizure Medications." Pharmaceutics 13, no. 8 (2021): 1208. http://dx.doi.org/10.3390/pharmaceutics13081208.

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Epilepsy is a widely diffused neurological disorder including a heterogeneous range of syndromes with different aetiology, severity and prognosis. Pharmacological treatments are based on the use, either in mono- or in polytherapy, of antiseizure medications (ASMs), which act at different synaptic levels, generally modifying the excitatory and/or inhibitory response through different action mechanisms. To reduce the risk of adverse effects and drug interactions, ASMs levels should be closely evaluated in biological fluids performing an appropriate Therapeutic Drug Monitoring (TDM). However, man

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Shaimardanova, Roza M., and Rimma G. Gamirova. "Long-term effectiveness and safety of antiepileptic drugs in children and adults." Reviews on Clinical Pharmacology and Drug Therapy 19, no. 2 (2021): 221–28. http://dx.doi.org/10.17816/rcf192221-228.

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AIM: To conduct a retrospective comparative analysis of the efficacy and safety of epilepsy therapy with antiepileptic drugs. MATERIALS AND METHODS: The analysis of the treatment of 428 patients with epilepsy at the Childrens City Hospital No. 8 in Kazan, receiving antiepileptic drugs. RESULTS: It was found that valproic acid is more effective in the treatment of idiopathic generalized epilepsies compared to focal epilepsies (p = 0.0006). Valproate and carbamazepine were the most effective in the treatment of focal epilepsy with short- and long-term follow-up. Valproic acid is more

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Spina, Edoardo, and Giulio Perugi. "Antiepileptic drugs: indications other than epilepsy." Epileptic Disorders 6, no. 2 (2004): 57–75. http://dx.doi.org/10.1684/j.1950-6945.2004.tb00053.x.

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ABSTRACT Antiepileptic drugs (AEDs) are increasingly used for the treatment of several non‐epileptic neurological conditions and psychiatric disorders. Most of the information available on the use of these agents in clinical disorders outside epilepsy is from case series, uncontrolled studies or small randomised clinical trials, and their apparent efficacy requires confirmation through well designed, large, phase III trials. With regard to neurological conditions other than epilepsy, experimental evidence for the efficacy of AEDs is only available for the treatment of patients with trigeminal

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Martsenkovsky, I. A., I. I. Martsenkovska, and H. V. Makarenko. "Use of antiepileptic drugs in mental disorders." INTERNATIONAL NEUROLOGICAL JOURNAL 20, no. 8 (2025): 454–60. https://doi.org/10.22141/2224-0713.20.8.2024.1129.

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Antiepileptic drugs (AEDs) are quite often used in psychiatric practice and are considered the drugs of choice for mental disorders, primarily recurrent and bipolar depression and mania, behavioral and anxiety disorders with signs of bipolar emotional dysregulation, mental disorders with dependence on psychoactive substances. The level of evidence for the use of AEDs varies, sometimes they are used outside the recommendations of the FDA, EMA, outside the instructions of the Pharmcenter of Ukraine. Currently, mood stabilizers such as valproate, lamotrigine, carbamazepine have the highest level

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Kowacs, Pedro André, Pedro Augusto Sampaio Rocha-Filho, Mário Fernando Prieto Peres, and Lars Edvinsson. "The history and rationale of the development of new drugs for migraine treatment." Arquivos de Neuro-Psiquiatria 81, no. 12 (2023): 1084–97. http://dx.doi.org/10.1055/s-0043-1777723.

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AbstractMigraine is one of the most prevalent and disabling diseases in the world. Migraine attack treatments and prophylactic treatments of this disease are essential to lessen its individual, social, and economic impact. This is a narrative review of the main drugs used for treating migraine, as well as the experimental models and the theoretical frameworks that led to their development. Ergot derivatives, triptans, non-steroid anti-inflammatory drugs, tricyclic antidepressants, beta-blockers, flunarizine, valproic acid, topiramate, onabotulinumtoxin A, ditans, monoclonal antibodies against

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Salve, Bhumika* Zanjad Aniket Deshmukh Komal Kalamkar Tejas. "A Review on Formulation and Evaluation of BI- Layered Tablet." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4527–36. https://doi.org/10.5281/zenodo.15535200.

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In order to achieve biphasic drug administration, the current review concentrates on the formulation and assessment of a 100 mg bi layered tablet of Divalproex Sodium that combines immediate release (IR) and sustained release (SR) components. A stable combination of sodium valproate and valproic acid, divalproex sodium is used extensively to treat epilepsy, bipolar disorder, and migraine prevention. But because of its brief half-life, frequent administration is required, which may result in noncompliance from patients. An efficient method to get around these restrictions is to use a bilayer pi

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Liakopoulou, E., CA Blau, Q. Li, et al. "Stimulation of fetal hemoglobin production by short chain fatty acids." Blood 86, no. 8 (1995): 3227–35. http://dx.doi.org/10.1182/blood.v86.8.3227.3227.

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Abstract Butyrate, a four-carbon fatty acid, and its two-carbon metabolic product, acetate, are inducers of gamma-globin synthesis. To test whether other short-chain fatty acids share this property, we first examined whether propionic acid, a three-carbon fatty acid that is not catabolized to acetate, induces gamma-globin expression. Sodium propionate increased the frequency of fetal hemoglobin containing erythroblasts and the gamma/gamma + beta mRNA ratios in adult erythroid cell cultures and F reticulocyte production in a nonanemic juvenile baboon. Short-chain fatty acids containing five (pe

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Liakopoulou, E., CA Blau, Q. Li, et al. "Stimulation of fetal hemoglobin production by short chain fatty acids." Blood 86, no. 8 (1995): 3227–35. http://dx.doi.org/10.1182/blood.v86.8.3227.bloodjournal8683227.

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Butyrate, a four-carbon fatty acid, and its two-carbon metabolic product, acetate, are inducers of gamma-globin synthesis. To test whether other short-chain fatty acids share this property, we first examined whether propionic acid, a three-carbon fatty acid that is not catabolized to acetate, induces gamma-globin expression. Sodium propionate increased the frequency of fetal hemoglobin containing erythroblasts and the gamma/gamma + beta mRNA ratios in adult erythroid cell cultures and F reticulocyte production in a nonanemic juvenile baboon. Short-chain fatty acids containing five (pentanoic),

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Cannizzaro, Elvira, Manuela Albisetti, Eva Bergstraesser, et al. "Severe Bleeding Complications during Antiepileptic Treatment with Valproic Acid in Children: A Description of Four Cases." Blood 106, no. 11 (2005): 2155. http://dx.doi.org/10.1182/blood.v106.11.2155.2155.

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Abstract Sodium valproat (VPA) is a commonly used antiepileptic drug in children. It is known to cause a variety of different haematological side effects, including thrombocytopenia, a decrease in plasma fibrinogen, von Willebrand factor (VWF)- and factor XIII, impaired platelet aggregation with ADP and Collagen and prolonged PFA-100 closure times. The mechanisms responsible for such a variety of haematological abnormalities are still poorly understood and controversy exists about their clinical relevance and the risk for significant bleeding. We report on 4 children with severe bleeding compl

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Rodríguez, M., V. Pérez, D. Linares, and S. Jose María. "Approach in a mental health hospitalization unit." European Psychiatry 41, S1 (2017): s798. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1537.

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IntroductionThe mental health hospitalization unit of Torrecárdenas Hospital consist of a team of professional psychologists, psychiatrists, nurses and occupational therapists who perform different approaches to look after the hospitalized patient. The therapeutic Objective of this unit is the containment and implementation of intensive interventions in a crisis situation in which it has not been possible to achieve an improvement or control of the patient's symptoms in external resources.Material and methodsWe performed a descriptive cross-sectional study with patients hospitalized at the men

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Solana, C., S. Nascimento, M. Duarte, and M. Mendes. "Clinical vignette – Aripiprazol long acting injection monotherapy as long-term treatment for bipolar disease." European Psychiatry 41, S1 (2017): S760—S761. http://dx.doi.org/10.1016/j.eurpsy.2017.01.1427.

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IntroductionOver the last decade a number of effective maintenance treatments for bipolar disorder (BPD) have been developed. Lithium remains the best-established option, but valproic acid, lamotrigine, olanzapine, and quetiapine are also effective maintenance drugs. However, oral administration contributes to lower adherence rates with these drugs. In the United States and Europe, aripiprazole is approved for the acute management of manic and mixed episodes and maintenance in BPD. It presents the advantage of a low risk of metabolic side effects, sexual dysfunction, and sedation, which can fa

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Mandal, Soumitra, Aruna Donepudi, Jabeen Shaik Afshan, and Suryaprabha Turaga. "A drug utilization study of antiepileptic drugs uses in a tertiary care teaching hospital of India." International Journal of Basic & Clinical Pharmacology 10, no. 11 (2021): 1293. http://dx.doi.org/10.18203/2319-2003.ijbcp20214120.

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Background: Epilepsy is a disorder characterized by repeated seizures due to the disorder of the neurons. Epilepsy needs life-long medical therapy. It is managed by polytherapy. Drug utilization studies help to determine rational combinations of drug use in epilepsy. Aims and objectives of the study were to analyses the drug utilization pattern of anti-epileptics and common types of epileptic seizures and to determine the safety of antiepileptic drugs (AEDs).Methods: It was a prospective, cross-sectional, observational study. Patients attending neurology epilepsy OPD with h/o seizures and taki

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Camussi, Diletta, Valentina Naef, Letizia Brogi, et al. "Delving into the Complexity of Valproate-Induced Autism Spectrum Disorder: The Use of Zebrafish Models." Cells 13, no. 16 (2024): 1349. http://dx.doi.org/10.3390/cells13161349.

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Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental condition with several identified risk factors, both genetic and non-genetic. Among these, prenatal exposure to valproic acid (VPA) has been extensively associated with the development of the disorder. The zebrafish, a cost- and time-effective model, is useful for studying ASD features. Using validated VPA-induced ASD zebrafish models, we aimed to provide new insights into VPA exposure effects during embryonic development and to identify new potential biomarkers associated with ASD-like features. Dose–response analyses were

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Shubnikova, E. V., M. A. Darmostukova, T. M. Bukatina, et al. "The Adverse Drug Reactions Registered During the Postmarketing Period." Safety and Risk of Pharmacotherapy 7, no. 1 (2019): 15–22. http://dx.doi.org/10.30895/2312-7821-2019-7-1-15-22.

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Efficacy, safety and biotransformation features of any drug are fully revealed during widely using. Therefore, postmarketing studies of the pharmacological properties of drugs are an integral component of pharmacovigilance. The aim of this study was to evaluate the nature and frequency of drugs adverse reactions that have been reported in the post-marketing period, as well as a review of measures taken by foreign regulatory authorities to ensure the safety of use of these drugs. The results of monitoring the drug safety in the post-marketing period used in clinical practice during various time

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Forthun, Rakel Brendsdal, Emmet McCormack, Tanima Sengupta, et al. "Identification of Molecular Targets of AML by Phosphoproteomic Screening of Valproic Acid Treated BNML and C. Elegans RNAi Validation." Blood 114, no. 22 (2009): 4151. http://dx.doi.org/10.1182/blood.v114.22.4151.4151.

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Abstract Abstract 4151 Disease stabilisation, instead of cure, is proposed as the therapeutic strategy of choice in elderly or chemoresistant acute myeloid leukemia (AML). This approach may also be of particular benefit to patients for whom allogeneic bone marrow (re)transplantation is not an option. Previously, we have clinically investigated the addition of valproic acid (VPA) to various combination chemotherapies with initial results in AML indicating prolonged survival, with follow-up on a predominantly out-patient basis. Consequently, we aimed to identify further molecular targets of VPA,

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Verstegen, Ruud H. J., Iris Cohn, Mark E. Feldman, Daniel Gorman, and Shinya Ito. "Gene-based drug therapy for children and youth treated with psychoactive medications." Paediatrics & Child Health 29, no. 5 (2024): 318–23. http://dx.doi.org/10.1093/pch/pxae029.

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Abstract Psychoactive medications are increasingly used to treat children and youth with mental health conditions, but individual variations in response highlight the need for precision medicine. Pharmacogenetic (PGx) testing is a key component of precision medicine. The number of commercial pharmacogenetic testing companies promoting PGx, with the promise of achieving individualized and effective treatment of mental health conditions, has grown exponentially in recent years. Scientific evidence supporting the use of PGx to manage mental health conditions is limited, especially for paediatric

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Pellegrino, Michele, Elena Ricci, Rosangela Ceraldi, et al. "From HDAC to Voltage-Gated Ion Channels: What’s Next? The Long Road of Antiepileptic Drugs Repositioning in Cancer." Cancers 14, no. 18 (2022): 4401. http://dx.doi.org/10.3390/cancers14184401.

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Cancer is a major health burden worldwide. Although the plethora of molecular targets identified in the last decades and the deriving developed treatments, which significantly improved patients’ outcome, the occurrence of resistance to therapies remains the major cause of relapse and mortality. Thus, efforts in identifying new markers to be exploited as molecular targets in cancer therapy are needed. This review will first give a glance on the diagnostic and therapeutic significance of histone deacetylase (HDAC) and voltage gated ion channels (VGICs) in cancer. Nevertheless, HDAC and VGICs hav

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