Relevant bibliographies by topics / Various parameters that affect colon delivery

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Academic literature on the topic 'Various parameters that affect colon delivery'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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Journal articles on the topic "Various parameters that affect colon delivery"

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Shikha, Jakhotiya, and Gajendra Singh Rathore Dr. "Approach on Colon-Targeted Drug Delivery Systems." Pharmaceutical and Chemical Journal 10, no. 3 (2023): 94–101. https://doi.org/10.5281/zenodo.13995565.

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Colon-specific drug delivery systems (CDDS) can be used to treat a variety of colon-related issues, including ulcerative colitis, colon cancer, Crohn's disease, irritable bowel syndrome, and chronic pancreatitis. Many medications used to treat conditions other than colon problems may also be absorbed systemically through the colon. If drugs like proteins and peptides—which are known to disintegrate in the excessive gastric pH—are transported to the colon intact, colonic mucosa can ingest them and absorb them systemically. The intended delivery mechanism must particularly target the
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Alfaleh, Mohamed A., Anwar M. Hashem, Turki S. Abujamel, et al. "Apigenin Loaded Lipoid–PLGA–TPGS Nanoparticles for Colon Cancer Therapy: Characterization, Sustained Release, Cytotoxicity, and Apoptosis Pathways." Polymers 14, no. 17 (2022): 3577. http://dx.doi.org/10.3390/polym14173577.

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Colon cancer (CC) is one of major causes of mortality and affects the socio-economic status world-wide. Therefore, developing a novel and efficient delivery system is needed for CC management. Thus, in the present study, lipid polymer hybrid nanoparticles of apigenin (LPHyNPs) was prepared and characterized on various parameters such as particle size (234.80 ± 12.28 nm), PDI (0.11 ± 0.04), zeta potential (−5.15 ± 0.70 mV), EE (55.18 ± 3.61%), etc. Additionally, the DSC, XRD, and FT-IR analysis determined drug entrapment and affinity with the selected excipient, demonstrating a promising drug a
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Ren, Shuqiang, Yan Hui, Karina Obelitz-Ryom, et al. "Neonatal gut and immune maturation is determined more by postnatal age than by postconceptional age in moderately preterm pigs." American Journal of Physiology-Gastrointestinal and Liver Physiology 315, no. 5 (2018): G855—G867. http://dx.doi.org/10.1152/ajpgi.00169.2018.

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Preterm infants have immature organ functions that predispose them to gut and immune disorders. Developmental delays at preterm birth may affect various organs differently at term-corrected age. We hypothesized that gut and immune maturation in moderately preterm neonates depends more on birth and postnatal factors than on advancing postconceptional age (PCA). Using preterm pigs as models, we investigated how gut and immune parameters develop until term-corrected age and how these differ from those in term counterparts. Preterm ( n = 43, 106 days of gestation) and term pigs ( n = 41, 116 days
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De Anda-Flores, Yubia, Elizabeth Carvajal-Millan, Alma Campa-Mada, et al. "Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems." Polysaccharides 2, no. 3 (2021): 626–47. http://dx.doi.org/10.3390/polysaccharides2030038.

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Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multi
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Rana, Ritik Singh, Yogita Ale, Pankaj Pant, Neha Kukreti, and Vikash Jakhmola. "Advancements in formulations and technologies for colon-targeted drug delivery." Journal of Applied Pharmaceutical Research 13, no. 2 (2025): 55–72. https://doi.org/10.69857/joapr.v13i2.825.

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Background: Colonic administration of drugs may enhance drug absorption, reduce adverse reactions, and facilitate delivery to specific therapeutic targets. Objective: Delivering pharmaceuticals to the colon poses challenges that require innovative formulation strategies. Methodology: Various formulation approaches have been explored for colon-targeted drug delivery systems. These approaches target the colon using formulation components that interact with GI physiology parameters such as pH, colonic flora, and enzymes. Result and Discussion: The article discussed the various research studies co
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Kaur, Veerpal, Amandeep Singh Amandeep Singh, Kirandeep Kaur, and Goutam Rath. "Targeted Based Drug Delivery System for Colon Cancer." Journal of Drug Delivery and Therapeutics 10, no. 1 (2020): 111–22. http://dx.doi.org/10.22270/jddt.v10i1.3831.

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Regardless of so many advancements in the treatment, colon cancer still stands third in cancer-related deaths worldwide. Toxicity associated with conventional drugs is one of the major problems associated with chemotherapy. Targeted delivery works by concentrating the medication in the tissues of interest and reducing the concentration in remaining tissues. This delivery system helps the drug molecule to reach preferably to the desired site. The targeting will lower the requirement of a higher dose of the drug thus reducing the dosage frequency. The present review focuses on the various parame
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G. Ingle, Tushar Kumar, Shrikant D. Pande, Sandeep Atram, Nishant Bobade, and Vikrant Wankhede. "Formulation and Evaluation of Microspheres for Colon Targeted Drug Delivery Using Anthelminthics Drugs." Asian Journal of Pharmaceutical Research and Development 11, no. 4 (2023): 36–45. http://dx.doi.org/10.22270/ajprd.v11i4.1283.

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The objective of this study was to develop sustained release microspheres for colon-targeted drug delivery system to enhance therapeutic efficacy while minimizing systemic side effects. The controlled and prolonged release of drugs in the colon can significantly improve the treatment outcomes for various colon-related diseases. Microspheres, small spherical particles with sizes ranging from 1 to 1000 micrometers, were formulated using biodegradable polymers and natural materials to ensure biocompatibility and controlled drug release. The formulation process involved the selection of appropriat
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Pravin, Suruse, Godbole Mangesh, Bhamre Kumudini, and Shivhare Umesh. "Formulation and Evaluation of Colon Targeted Drug Delivery System." Indo Global Journal of Pharmaceutical Sciences 12 (2022): 115–21. http://dx.doi.org/10.35652/igjps.2022.12011.

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Purpose:The objective of the present study was to develop colon targeted drug delivery system of Metronidazole using guar gum as the carrier.Methods:Matrix tablets containing various proportions of guar gum were prepared by direct compression technique. Rapidly disintegrating Metronidazole core tablets were prepared and compression coated with guar gum and 20% of microcrystalline cellulose. The tablets were evaluated for hardness, thickness, drug uniformity and subjected to in vitro drug release studies under conditions mimicking mouth to colon transit. Results and Conclusions: The FTIR study
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Gonekar, Rinku, and Mohan Lal Kori. "Preparation and characterization of azathioprine microspheres for colon specific delivery." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 97–101. http://dx.doi.org/10.22270/jddt.v9i2.2519.

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The objective of the present study is to develop colon targeted drug delivery system using dextrin (polysaccharide) as a carrier for Azathioprine. Microspheres containing azathioprine, dextrin and various excipients were prepared by solvent evaporation technique. The prepared microsphere were evaluated by different methods parameters like particle size, drug entrapment efficiency, percentage yield, shape and surface morphology and in vitro drug release study. Drug release profile was evaluated in simulated gastric, intestinal fluid and simulated colonic fluid. Best formulation was decided on t
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Vivekanandan, K. 1. *. Dr. Gunasekaran V. 2. "DEVELOPMENT OF COLON TARGETED SUSTAINED RELEASE MATRIX TABLETS OF PREDNISOLONE." Journal of Pharma Research 7, no. 9 (2018): 210–15. https://doi.org/10.5281/zenodo.1421240.

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<strong><em>ABSTARCT</em></strong> <strong><em>I</em></strong><em>n the present research work sustained release matrix formulation of prednisolone targeted to colon by using various polymers developed. </em><em>Various eudragit polymers were employed as polymers. Prednisolone dose was fixed as 20 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 30, 60 and 90 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was eviden
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Book chapters on the topic "Various parameters that affect colon delivery"

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Mohammad, Nemati, Ahmadian Zainab, Mohammadi Zahra, and Adeli Mohsen. "Stimuli-responsive Systems for Wound Healing." In Carrier-mediated Gene and Drug Delivery for Dermal Wound Healing. Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671540-00215.

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Skin lesions and reducing their healing times are important health issues that require more efficient treatments and improvements to the current therapies. A wound is any type of rupture in the cohesion of layers of skin (epidermis, dermis and hypodermis) or subcutaneous tissue that can be caused by physical or chemical factors. Wounds can be classified as acute or chronic. Acute wounds refer to a group of wounds that are usually superficial and heal completely within 6 to 12 weeks, but chronic wounds require more than 12 weeks to be healed. Wound healing takes place through a complex and adva
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Singh, Hasandeep, Brahmjot Singh, Ankita Rajput, et al. "Chemomodulatory Potential of Lutein Derived from Dietary Sources." In Functional Foods for Health Maintenance: Understanding their Role in Cancer Prevention. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815179217123010013.

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The mortality rate from various types of cancer is unacceptably high till date. Although, there is a huge advancement in understanding the diverse mechanisms of carcinogenesis and the development of potential drug leads, still there are massive mortality rates. The consumption of various green/yellow vegetables and fruits can help in reducing the risk of cancer. There is a plethora of potential anticancer compounds present in green leafy vegetables, which have been extensively evaluated in cancer. Various anticancer leads include dietary agents in which carotenoids are very significant in comb
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Sethi, Srinivas, and Sai Sruti. "Cloud Security Issues and Challenges." In Advances in Systems Analysis, Software Engineering, and High Performance Computing. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-1721-4.ch004.

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Cloud computing refers to the basic setup for an emerging model of service delivery, that has the advantage of decreasing the cost by sharing computing, infrastructure including storage resources. This can be combined with on-demand delivery mechanism relying on a pay-per-use model. Cloud computing offers an added level of risk because of essential services provided by it to a third party, which makes it difficult to maintain data privacy and security. Security in cloud computing is a critical aspect, which has various issues and challenges related to it. Cloud service providers/ brokers and t
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Sethi, Srinivas, and Sai Sruti. "Cloud Security Issues and Challenges." In Cyber Security and Threats. IGI Global, 2018. http://dx.doi.org/10.4018/978-1-5225-5634-3.ch005.

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Cloud computing refers to the basic setup for an emerging model of service delivery, that has the advantage of decreasing the cost by sharing computing, infrastructure including storage resources. This can be combined with on-demand delivery mechanism relying on a pay-per-use model. Cloud computing offers an added level of risk because of essential services provided by it to a third party, which makes it difficult to maintain data privacy and security. Security in cloud computing is a critical aspect, which has various issues and challenges related to it. Cloud service providers/ brokers and t
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Baxi, Bhavya, and Jigna Shah. "Association of Pre-Pregnancy Body Mass Index and Gestational Weight Gain with Preterm Delivery in Pregnant Women." In Caesarean Section [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96922.

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The perinatal mortality rate, which is one of the important adverse pregnancy outcome and includes stillbirths and infant death within first week of life is estimated to be nearly 40 deaths per 1,000 pregnancies in Gujarat. Also the infant mortality rates have been estimated to be 50 deaths before age of one year per 1,000 pregnancies. It is stated that children whose mothers are illiterate or belong to low socio-economic class have two and half times more chances to die within 1 year of their birth compared to those whose mothers have completed atleast 10 years of education or belong to high
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Verma, Dr Garima, Dr Ajay Kumar Shukla, and Dr Vimal Kumar Yadav. "DOSAGE FORM DESIGN." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 7. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bapn7p1ch1.

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The design of dosage forms plays a critical role in the development and delivery of pharmaceutical products. It involves the careful selection and combination of excipients, drug substances, and manufacturing processes to create safe, effective, and patient-friendly dosage forms. This abstract provides an overview of the key considerations and principles involved in the design of dosage forms. The design process begins with a thorough understanding of the physicochemical properties of the drug substance, such as solubility, stability, and bioavailability. This knowledge guides the selection of
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Conference papers on the topic "Various parameters that affect colon delivery"

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V, Padmasri, Vikraman Vellandi, Raghupathi Sundaram, Ram Krishnan Singh, Praveen P, and Santhosh Chittibabu. "A Parametric Analysis of Relationship between Tyre and Braking Performances in Electric Vehicle." In 11th SAEINDIA International Mobility Conference (SIIMC 2024). SAE International, 2024. https://doi.org/10.4271/2024-28-0180.

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&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Sports Utility Vehicles (SUVs) Braking performance is a critical parameter, and it is described by the measure of stopping distance &amp;amp; stability of the vehicle at a specified speed. When it comes to electric vehicles, balancing tyre performance parameters like RRc, traction, wear, ride and handling, weight and NVH is challenging due to higher axle weights, higher moment of inertia and high instant torque delivery. This study presents the braking performances of EV-intended tyres at various contact surfaces in both
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Zhou, Alan X. L., Victor Cabrejo, and David Yu. "Pressure Surge Relief Options in Terminal Design." In 2014 10th International Pipeline Conference. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/ipc2014-33488.

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Terminals are an integral part of a pipeline system. Typically, petroleum products are transported from an initiating terminal to various delivery terminals along the pipeline. Operation safety is paramount in transporting petroleum products in the pipeline industry. Safety can affect the performance and economics of a pipeline system. While effective operation safety requires well-trained operators, operational procedures, and compliance with regulatory requirements, the best way to ensure operation safety is to implement safety systems during the design stage of the pipeline system. A pressu
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Donald, J. Adam, Erik Wielemaker, Chris Holmes, and Tom Neville. "WELLSITE FULL WAVEFORM SONIC INTERPRETATION." In 2021 SPWLA 62nd Annual Logging Symposium Online. Society of Petrophysicists and Well Log Analysts, 2021. http://dx.doi.org/10.30632/spwla-2021-0022.

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Sonic data are now acquired in most wellbores for a variety of applications including seismic tie, porosity evaluation, lithology determination, fracture detection, gas detection, and geomechanics modeling. The industry is also more aware of the impacts of intrinsic (fractures, layering), extrinsic (stress), and borehole effects that may affect the basic measurements of compressional and shear slownesses. Any advanced interpretation of sonic data has historically been done days to weeks after the acquisition, and the value of the measurement can be diminished due to the time of delivery of the
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