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Journal articles on the topic 'Various parameters that affect colon delivery'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Shikha, Jakhotiya, and Gajendra Singh Rathore Dr. "Approach on Colon-Targeted Drug Delivery Systems." Pharmaceutical and Chemical Journal 10, no. 3 (2023): 94–101. https://doi.org/10.5281/zenodo.13995565.

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Colon-specific drug delivery systems (CDDS) can be used to treat a variety of colon-related issues, including ulcerative colitis, colon cancer, Crohn's disease, irritable bowel syndrome, and chronic pancreatitis. Many medications used to treat conditions other than colon problems may also be absorbed systemically through the colon. If drugs like proteins and peptides—which are known to disintegrate in the excessive gastric pH—are transported to the colon intact, colonic mucosa can ingest them and absorb them systemically. The intended delivery mechanism must particularly target the

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Alfaleh, Mohamed A., Anwar M. Hashem, Turki S. Abujamel, et al. "Apigenin Loaded Lipoid–PLGA–TPGS Nanoparticles for Colon Cancer Therapy: Characterization, Sustained Release, Cytotoxicity, and Apoptosis Pathways." Polymers 14, no. 17 (2022): 3577. http://dx.doi.org/10.3390/polym14173577.

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Colon cancer (CC) is one of major causes of mortality and affects the socio-economic status world-wide. Therefore, developing a novel and efficient delivery system is needed for CC management. Thus, in the present study, lipid polymer hybrid nanoparticles of apigenin (LPHyNPs) was prepared and characterized on various parameters such as particle size (234.80 ± 12.28 nm), PDI (0.11 ± 0.04), zeta potential (−5.15 ± 0.70 mV), EE (55.18 ± 3.61%), etc. Additionally, the DSC, XRD, and FT-IR analysis determined drug entrapment and affinity with the selected excipient, demonstrating a promising drug a

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Ren, Shuqiang, Yan Hui, Karina Obelitz-Ryom, et al. "Neonatal gut and immune maturation is determined more by postnatal age than by postconceptional age in moderately preterm pigs." American Journal of Physiology-Gastrointestinal and Liver Physiology 315, no. 5 (2018): G855—G867. http://dx.doi.org/10.1152/ajpgi.00169.2018.

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Preterm infants have immature organ functions that predispose them to gut and immune disorders. Developmental delays at preterm birth may affect various organs differently at term-corrected age. We hypothesized that gut and immune maturation in moderately preterm neonates depends more on birth and postnatal factors than on advancing postconceptional age (PCA). Using preterm pigs as models, we investigated how gut and immune parameters develop until term-corrected age and how these differ from those in term counterparts. Preterm ( n = 43, 106 days of gestation) and term pigs ( n = 41, 116 days

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De Anda-Flores, Yubia, Elizabeth Carvajal-Millan, Alma Campa-Mada, et al. "Polysaccharide-Based Nanoparticles for Colon-Targeted Drug Delivery Systems." Polysaccharides 2, no. 3 (2021): 626–47. http://dx.doi.org/10.3390/polysaccharides2030038.

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Polysaccharide biomaterials have gained significant importance in the manufacture of nanoparticles used in colon-targeted drug delivery systems. These systems are a form of non-invasive oral therapy used in the treatment of various diseases. To achieve successful colonic delivery, the chemical, enzymatic and mucoadhesive barriers within the gastrointestinal (GI) tract must be analyzed. This will allow for the nanomaterials to cross these barriers and reach the colon. This review provides information on the development of nanoparticles made from various polysaccharides, which can overcome multi

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Rana, Ritik Singh, Yogita Ale, Pankaj Pant, Neha Kukreti, and Vikash Jakhmola. "Advancements in formulations and technologies for colon-targeted drug delivery." Journal of Applied Pharmaceutical Research 13, no. 2 (2025): 55–72. https://doi.org/10.69857/joapr.v13i2.825.

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Background: Colonic administration of drugs may enhance drug absorption, reduce adverse reactions, and facilitate delivery to specific therapeutic targets. Objective: Delivering pharmaceuticals to the colon poses challenges that require innovative formulation strategies. Methodology: Various formulation approaches have been explored for colon-targeted drug delivery systems. These approaches target the colon using formulation components that interact with GI physiology parameters such as pH, colonic flora, and enzymes. Result and Discussion: The article discussed the various research studies co

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Kaur, Veerpal, Amandeep Singh Amandeep Singh, Kirandeep Kaur, and Goutam Rath. "Targeted Based Drug Delivery System for Colon Cancer." Journal of Drug Delivery and Therapeutics 10, no. 1 (2020): 111–22. http://dx.doi.org/10.22270/jddt.v10i1.3831.

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Regardless of so many advancements in the treatment, colon cancer still stands third in cancer-related deaths worldwide. Toxicity associated with conventional drugs is one of the major problems associated with chemotherapy. Targeted delivery works by concentrating the medication in the tissues of interest and reducing the concentration in remaining tissues. This delivery system helps the drug molecule to reach preferably to the desired site. The targeting will lower the requirement of a higher dose of the drug thus reducing the dosage frequency. The present review focuses on the various parame

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G. Ingle, Tushar Kumar, Shrikant D. Pande, Sandeep Atram, Nishant Bobade, and Vikrant Wankhede. "Formulation and Evaluation of Microspheres for Colon Targeted Drug Delivery Using Anthelminthics Drugs." Asian Journal of Pharmaceutical Research and Development 11, no. 4 (2023): 36–45. http://dx.doi.org/10.22270/ajprd.v11i4.1283.

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The objective of this study was to develop sustained release microspheres for colon-targeted drug delivery system to enhance therapeutic efficacy while minimizing systemic side effects. The controlled and prolonged release of drugs in the colon can significantly improve the treatment outcomes for various colon-related diseases. Microspheres, small spherical particles with sizes ranging from 1 to 1000 micrometers, were formulated using biodegradable polymers and natural materials to ensure biocompatibility and controlled drug release. The formulation process involved the selection of appropriat

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Pravin, Suruse, Godbole Mangesh, Bhamre Kumudini, and Shivhare Umesh. "Formulation and Evaluation of Colon Targeted Drug Delivery System." Indo Global Journal of Pharmaceutical Sciences 12 (2022): 115–21. http://dx.doi.org/10.35652/igjps.2022.12011.

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Purpose:The objective of the present study was to develop colon targeted drug delivery system of Metronidazole using guar gum as the carrier.Methods:Matrix tablets containing various proportions of guar gum were prepared by direct compression technique. Rapidly disintegrating Metronidazole core tablets were prepared and compression coated with guar gum and 20% of microcrystalline cellulose. The tablets were evaluated for hardness, thickness, drug uniformity and subjected to in vitro drug release studies under conditions mimicking mouth to colon transit. Results and Conclusions: The FTIR study

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Gonekar, Rinku, and Mohan Lal Kori. "Preparation and characterization of azathioprine microspheres for colon specific delivery." Journal of Drug Delivery and Therapeutics 9, no. 2 (2019): 97–101. http://dx.doi.org/10.22270/jddt.v9i2.2519.

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The objective of the present study is to develop colon targeted drug delivery system using dextrin (polysaccharide) as a carrier for Azathioprine. Microspheres containing azathioprine, dextrin and various excipients were prepared by solvent evaporation technique. The prepared microsphere were evaluated by different methods parameters like particle size, drug entrapment efficiency, percentage yield, shape and surface morphology and in vitro drug release study. Drug release profile was evaluated in simulated gastric, intestinal fluid and simulated colonic fluid. Best formulation was decided on t

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Vivekanandan, K. 1. *. Dr. Gunasekaran V. 2. "DEVELOPMENT OF COLON TARGETED SUSTAINED RELEASE MATRIX TABLETS OF PREDNISOLONE." Journal of Pharma Research 7, no. 9 (2018): 210–15. https://doi.org/10.5281/zenodo.1421240.

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<strong><em>ABSTARCT</em></strong> <strong><em>I</em></strong><em>n the present research work sustained release matrix formulation of prednisolone targeted to colon by using various polymers developed. </em><em>Various eudragit polymers were employed as polymers. Prednisolone dose was fixed as 20 mg. Total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 30, 60 and 90 mg concentration. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was eviden

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Prasad, Garrepally. "Design and Optimization of Metformin Hcl of Colon Targeted Drug Delivery System." Journal of Clinical and Medical Case Reports and Reviews 1, no. 1 (2021): 1–4. http://dx.doi.org/10.59468/2837-469x/001.

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The aim of the present study was to develop colon targeted matrix tablets of Metformin HCl using various conc. of selected polymers such as HPMC, Ethyl Cellulose Guar gum and combination of the same. Tablets were prepared by direct compression method and both pre- compression and post- compression parameters for all batches shows in the acceptable ranges.Short term accelerated stability studies was performed according to ICH guidelines temperature of 400±20 and relative humidity of 75%±5% RH to study any physical changesand chemical decomposition of drug, no formulation shown any physical or c

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Tambe, Srushti, and Namita Desai. "Development and Evaluation of Bioresponsive Tablets of a Selective COX-2 Inhibitor for Colonic Delivery." Drug Delivery Letters 10, no. 1 (2020): 72–83. http://dx.doi.org/10.2174/2210303109666190828095726.

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Background: We report the effectiveness of a targeted delivery system containing Meloxicam using polysaccharides for the treatment of colorectal cancer. We also propose a novel biorelevant dissolution method to overcome drawbacks of existing dissolution methodologies of polysaccharidebased systems. The proposed method includes a mixture of probiotics cultured under anaerobic conditions in the presence of prebiotic in the in vitro dissolution study to surrogate colonic conditions. Polysaccharide- based system can be simple, safe and effective drug delivery system to target drugs to colon. Metho

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Khan, Samiullah, and Naveed Anwar. "Highly Porous pH-Responsive Carboxymethyl Chitosan-Grafted-Poly (Acrylic Acid) Based Smart Hydrogels for 5-Fluorouracil Controlled Delivery and Colon Targeting." International Journal of Polymer Science 2019 (February 14, 2019): 1–15. http://dx.doi.org/10.1155/2019/6579239.

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In the present investigation, new formulations of CMCS/AA hydrogels with varying composition of Carboxymethyl chitosan, acrylic acid, and ethylene glycol dimethacrylate (EGDMA) were prepared by free radical polymerization technique using benzoyl peroxide as catalyst. The bioavailability of 5-FU through the oral route is very limited owing to its rapid metabolism and clearance from the general circulation. Current work was aimed at increasing the bioavailability of 5-FU via smart hydrogels and at investigating their potential in delivering 5-FU to target colon cancer. Swelling studies were carr

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Chime, Salome A., Paul A. Akpa, and Anthony A. Attama. "The Utility of Lipids as Nanocarriers and Suitable Vehicle in Pharmaceutical Drug Delivery." Current Nanomaterials 4, no. 3 (2019): 160–75. http://dx.doi.org/10.2174/2405461504666191016091827.

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Lipid based excipients have gained popularity recently in the formulation of drugs in order to improve their pharmacokinetic profiles. For drugs belonging to the Biopharmaceutics Classification System (BCS) class II and IV, lipid excipients play vital roles in improving their pharmacokinetics properties. Various nanocarriers viz: Solid lipid nanoparticles, nanostructured lipid carriers, selfnanoemulsifying drug delivery systems (SNEDDS), nanoliposomes and liquid crystal nanoparticles have been employed as delivery systems for such drugs with evident successes. Lipid-based nanotechnology have b

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Wang, Guipu, Jianyu Yang, and Fangtang Xu. "Analyzing Express Revenue Spatial Association Network’s Characteristics and Effects: A Case Study of 31 Provinces in China." Sustainability 15, no. 1 (2022): 276. http://dx.doi.org/10.3390/su15010276.

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In recent years, China’s express delivery industry has experienced significant regional differences in income, which may endanger the sustainable development of the economy and affect the sustainable development of society. To study the development setup and influencing factors of the express delivery industry in various regions of China, based on the income data of provincial express delivery, we constructed a spatial correlation network of provincial express revenue in China using the social network analysis method and analyzed its network characteristics and evolution rules. Additionally, t

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S, Subimol, and Amjadkhan A. Pathan. "Formulation And In Vitro, In Vivo Evaluation of Colon Targeted Drug Delivery System Of 5-Fluorouracil." International Journal of Membrane Science and Technology 10, no. 3 (2023): 3753–67. http://dx.doi.org/10.15379/ijmst.v10i3.3636.

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Colon-targeted drug delivery systems can provide therapeutic benefits including better patient compliance and lower costs. The present investigation is aimed to design a colon specific microbially triggered system using biodegradable co-polymer mixtures. The calibration curves of 5-FU were measured in distilled water, 0.1N HCl and phosphate buffer of pH 6.8 and 7.4 which showed good linearity. Compatibility study of pure drugs, excipients and their physical mixtures were evaluated and passed as per standards. Solubility determination was carried out in different solvents. Satisfactory results

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17

Gorodetsky, Raphael, Astar Lazmi Hailu, Evgenia Volinsky, Boaz Adani, Orit Pappo, and Eran Israeli. "The Use of Potent Populations of Expanded Fetal Human Placental Stromal Cells for the Treatment of Dextran Sodium Sulfate-Induced Colitis in a Mouse Model." International Journal of Molecular Sciences 26, no. 7 (2025): 3222. https://doi.org/10.3390/ijms26073222.

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Inflammatory Bowel Disease (IBD) is a multifactorial gastrointestinal condition encompassing two major forms of intestinal inflammation: Crohn’s disease (CD) and ulcerative colitis (UC). Both conditions are linked to auto-inflammatory reactions and genetic predispositions. Various drug therapies and biological treatments proposed to reduce IBD-associated inflammation. We induced IBD in a mouse model by stimulating bowel inflammation with an oral dextran sodium sulfate (DSS) beverage. Our novel cell therapy approach for IBD involves intramuscular (IM) and intraperitoneal (IP) delivery of non-ma

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18

Desai, Preshita P., Sanyat S. Mapara, and Vandana B. Patravale. "Crystal Engineering: Upcoming Paradigm for Efficacious Pulmonary Drug Delivery." Current Pharmaceutical Design 24, no. 21 (2018): 2438–55. http://dx.doi.org/10.2174/1381612824666180518080948.

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Background and objective: Pulmonary drug delivery has transformed over a past few decades from being a platform for local pulmonary disease treatment to systemic drug delivery opportunities. In case of pulmonary delivery systems, particle properties are critical as they affect inhalation efficacy, pulmonary deposition, drug delivery and overall performance. With this in view, particle engineering has emerged as an advanced science that helps in designing of efficacious pulmonary delivery systems. Among various particle engineering branches, crystal engineering is being extensively explored as

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Tripathi, Thapa, Maharjan, and Jeong. "Current State and Future Perspectives on Gastroretentive Drug Delivery Systems." Pharmaceutics 11, no. 4 (2019): 193. http://dx.doi.org/10.3390/pharmaceutics11040193.

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In recent years, many attempts have been made to enhance the drug bioavailability and therapeutic effectiveness of oral dosage forms. In this context, various gastroretentive drug delivery systems (GRDDS) have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. In this review, we discuss the physiological state of the stomach and various factors that affect GRDDS. Recently applied gastrointestinal technologies such as expandable, superporous hydrogel; b

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Surutha Lakshmi L., Vinu, Syed Shahid Raza, and Praveen Gujjar. "AN ANALYTICS APPROACH TO STUDYING THE IMPACT OF ONLINE FOOD DELIVERY PARTNERS ON CUSTOMER SATISFACTION AT RESTAURANTS." International Journal of Advanced Research 12, no. 04 (2024): 40–45. http://dx.doi.org/10.21474/ijar01/18514.

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The emergence of digital meal delivery platforms has completely changed the restaurant business and the way customers eat. This thesis looks into how online meal delivery partners affect restaurant patron satisfaction levels using an analytics-driven methodology. The studys objectives are to identify the critical elements that influence customer happiness and determine how delivery services affect a restaurants overall performance. The study technique makes use of a variety of datasets to conduct a multidimensional examination. The foundation of the analytical framework is made up of survey da

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Dibaji, Seyed Ahmad Reza, Berk Oktem, Lee Williamson, et al. "Characterization of aerosols generated by high-power electronic nicotine delivery systems (ENDS): Influence of atomizer, temperature and PG:VG ratios." PLOS ONE 17, no. 12 (2022): e0279309. http://dx.doi.org/10.1371/journal.pone.0279309.

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The aerosol characteristics of electronic nicotine delivery systems (ENDS) are important parameters in predicting health outcomes since parameters such as aerosol particle size correlate strongly to aerosol delivery and deposition efficiency. However, many studies to date do not account for aerosol aging, which may affect the measurement of ultra-fine particles that typically coagulate or agglomerate during puff development. To reduce aerosol aging, we herein present a unique instrumentation method that combines a) positive pressure ENDS activation and sample collection, b) minimization of bot

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Subhani, Saima, Viera Lukacova, Chaejin Kim, et al. "Leveraging Physiologically Based Modelling to Provide Insights on the Absorption of Paliperidone Extended-Release Formulation under Fed and Fasting Conditions." Pharmaceutics 15, no. 2 (2023): 629. http://dx.doi.org/10.3390/pharmaceutics15020629.

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Paliperidone was approved by the US FDA in 2006 as an extended-release (ER) tablet (Invega®) for the once-daily treatment of schizophrenia. This osmotic-controlled release oral delivery system (OROS) offers advantages, such as the prevention of plasma concentration fluctuation and reduced dosing frequency. The administration of the ER after a high-fat/high-calorie meal leads to increased maximum plasma concentration and area under the curve values by 60% and 54%, respectively. Food has various effects on gastrointestinal (GI) physiology, including changed transit times, changed volumes, altere

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Melocchi, Alice, Marco Uboldi, Francesco Briatico-Vangosa, et al. "The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM)." Pharmaceutics 13, no. 5 (2021): 759. http://dx.doi.org/10.3390/pharmaceutics13050759.

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The pulsatile-release Chronotopic™ system was conceived of as a drug-containing core surrounded by a coat made of swellable/soluble hydrophilic polymers, the latter being able to provide a programmable lag phase prior to drug liberation. This system was also proposed in a colon-targeting configuration, entailing a gastroresistant film to prevent early interaction of the inner coat with gastric fluids and enabling the attainment of a lag phase matching the small intestinal transit time. Over the years, various multiple-step manufacturing processes have been tested for the fabrication of the Chr

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Loomba, Rohit S., Fabio Savorgnan, Sebastian Acosta, et al. "Clinical Interventions and Hemodynamic Monitoring in the Setting of Left Ventricular Systolic Heart Failure in Children: Insights From a Physiologic Simulator." American Journal of Therapeutics 31, no. 5 (2024): e531-e540. http://dx.doi.org/10.1097/mjt.0000000000001711.

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Background: In pediatric critical care, vasoactive/inotropic support is widely used in patients with heart failure, but it remains controversial because the influence of multiple medications and the interplay between their inotropic and vasoactive effects on a given patient are hard to predict. Robust evidence supporting their use and quantifying their effects in this group of patients is scarce. Study Question: The aim of this study was to characterize the effect of vasoactive medications on various cardiovascular parameters in pediatric patient with decreased ejection fraction. Study Design:

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Saroj, Neetishwar, Preeti Rawat, Priyanka Rathour, Lokesh Mani Saroj, and Rajesh Kumar. "Preparation and Evaluation of Sustained Release Colon Targeted Micropellets of Lornoxicam." Pharmaceutical Methods 8, no. 2 (2017): 75–80. https://doi.org/10.5281/zenodo.14856396.

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The aim of the present work was to develop and evaluate sustained release colon targeted micropellets of lornoxicam in order to achieve release of the drug at colon which could result in enhanced local absorption and thereby improved bio-availability. The present worker prepared micropellets of lornoxicam in nine batches using pure drug, DCP, PVPK-30 and different ratios of HPMCK-4M taking into account the direct pelletization technique. Resulted micropellets were fiilled in capsules and coated with eudragit S-100 to achieve colon targeted release. Compatibility studies were by using FTIR and

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Kumar, Mohit, Devesh Kumar, Shubham Singh, Shruti Chopra, Syed Mahmood, and Amit Bhatia. "Quality by Design Perspective for Designing Foam-based Formulation: Current State of Art." Current Pharmaceutical Design 30, no. 6 (2024): 410–19. http://dx.doi.org/10.2174/0113816128289965240123074111.

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Abstract: Foam-based delivery systems contain one or more active ingredients and dispersed solid or liquid components that transform into gaseous form when the valve is actuated. Foams are an attractive and effective delivery approach for medical, cosmetic, and pharmaceutical uses. The foams-based delivery systems are gaining attention due to ease of application as they allow direct application onto the affected area of skin without using any applicator or finger, hence increasing the compliance and satisfaction of the patients. In order to develop foam-based delivery systems with desired qual

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Geraili, Armin, and Kibret Mequanint. "Systematic Studies on Surface Erosion of Photocrosslinked Polyanhydride Tablets and Data Correlation with Release Kinetic Models." Polymers 12, no. 5 (2020): 1105. http://dx.doi.org/10.3390/polym12051105.

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Photocrosslinkable polyanhydrides that undergo surface erosion are suitable materials for controlled-release drug delivery systems. Investigating the impact of different parameters on their erosion behavior is essential before use in drug delivery systems. Although their synthesis is well-established, parameters that may substantially affect the erosion of thiol-ene polyanhydrides including temperature and pH of the media, the geometry of the polymers, and the media shaking rate (the convective force for the polymer erosion), have not yet been studied. This study explores the effects of differ

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Biswas, Monalisa, Allabhakshu Shaik, and Krishnananda Prabhu. "Does serum Vitamin D affect lipid profile?" Biomedicine 41, no. 4 (2021): 787–92. http://dx.doi.org/10.51248/.v41i4.908.

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Introduction and Aim: Vitamin D, besides its classical physiological functions, exerts effects on brain, prostate, breast, colon, pancreas, and immune cells due to the ubiquitous presence of its receptors. Hypovitaminosis D predisposes individuals to various micro and macro vascular complications of metabolic syndrome and diabetes mellitus. Despite speculations regarding implications of its deficiency on the cardio metabolic health of general/ susceptible population, its role remains underexplored in the Indian population. Materials and Methods: This cross-sectional study carried out in Bioche

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Tincu, Robert, Mirela Mihaila, Marinela Bostan, Daniela Istrati, Nicoleta Badea, and Ioana Lacatusu. "Hybrid Albumin-Decorated Lipid-Nanocarrier-Mediated Delivery of Polyphenol-Rich Sambucus nigra L. in a Potential Multiple Antitumoural Therapy." International Journal of Molecular Sciences 25, no. 20 (2024): 11206. http://dx.doi.org/10.3390/ijms252011206.

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The current research attempted to address the suitability of bioactive Sambucus nigra extract entrapped in albumin-decorated nanostructured lipid carriers (NLCs) as a promising “adjuvant” in improving tumour penetration for multiple antitumour therapy. The new hybrid albumin-decorated NLCs were characterised based on, e.g., the particle size, zeta electrokinetic potential, SambucusN entrapment efficiency, and fluorescence spectroscopy and tested for different formulation parameters. The antioxidant activity of NLC-SambucusN was significantly enhanced by a bovine serum albumin (BSA) polymer coa

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Alshraim, Mohammed, Sibghatullah Sangi, Gamaleldin Harisa, Abdullah Alomrani, Osman Yusuf, and Mohamed Badran. "Chitosan-Coated Flexible Liposomes Magnify the Anticancer Activity and Bioavailability of Docetaxel: Impact on Composition." Molecules 24, no. 2 (2019): 250. http://dx.doi.org/10.3390/molecules24020250.

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Flexible liposomes (FLs) were developed as promising nano-carriers for anticancer drugs. Coating them with chitosan (CS) could improve their drug delivery properties. The aim of this study was to investigate the physicochemical characteristics, pharmacokinetics behavior, and cytotoxic efficacy of docetaxel (DTX)-loaded CS-coated FLs (C-FLs). DTX-loaded FLs and C-FLs were produced via thin-film evaporation and electrostatic deposition methods, respectively. To explore their physicochemical characterization, the particle size, zeta potential, encapsulation efficiency (EE%), morphology, and DTX r

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Labelle, Marc-André, Pompilia Ispas-Szabo, Salma Tajer, Yong Xiao, Benoît Barbeau, and Mircea Alexandru Mateescu. "Anionic and Ampholytic High-Amylose Starch Derivatives as Excipients for Pharmaceutical and Biopharmaceutical Applications: Structure-Properties Correlations." Pharmaceutics 15, no. 3 (2023): 834. http://dx.doi.org/10.3390/pharmaceutics15030834.

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Many chemical modifications of starch are realized in organic (mostly methanol) phase, allowing high degrees of substitution (DS). Some of these materials are used as disintegrants. To expand the usage of starch derivative biopolymers as drug delivery system, various starch derivatives obtained in aqueous phase were evaluated with the aim to identify materials and procedures which would generate multifunctional excipients providing gastro-protection for controlled drug delivery. Chemical, structural and thermal characteristics of anionic and ampholytic High Amylose Starch (HAS) derivatives und

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Ratne, Nandini, Shankar Gavaroji, Samriti Vohra, et al. "Formulation and Assessment of Prednisolone Matrix Tablets with a Blend of Natural Polysaccharides: Colon-Specific Drug Delivery Via Wet Granulation Approach." Journal of Neonatal Surgery 14, no. 7S (2025): 331–46. https://doi.org/10.52783/jns.v14.2414.

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This study aimed to evaluate the formulation and characterization of matrix tablets using a natural polysaccharide blend of Angelica sinensis polysaccharide and Tamarind Seed Polysaccharide (AT-P). The blend was prepared in a 1:1 ratio and assessed for its potential as a binding agent in controlled-release tablet formulations. Preformulation studies, including pH, viscosity, bulk density, tapped density, and compressibility index, were conducted to ensure compatibility and stability. Five matrix tablet formulations (TF1 to TF5) were developed using wet granulation with Prednisolone as the acti

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Weng, Jiaqi, Alain Durand, and Stéphane Desobry. "Chitosan-Based Particulate Carriers: Structure, Production and Corresponding Controlled Release." Pharmaceutics 15, no. 5 (2023): 1455. http://dx.doi.org/10.3390/pharmaceutics15051455.

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The state of the art in the use of chitosan (CS) for preparing particulate carriers for drug delivery applications is reviewed. After evidencing the scientific and commercial potentials of CS, the links between targeted controlled activity, the preparation process and the kinetics of release are detailed, focusing on two types of particulate carriers: matrix particles and capsules. More precisely, the relationship between the size/structure of CS-based particles as multifunctional delivery systems and drug release kinetics (models) is emphasized. The preparation method and conditions greatly i

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Kostenko, V. V., A. A. Boyko, M. V. Grechikhina, O. V. Ovsyanikova, and A. M. Sapozhnikov. "Expression of membrane HSP70 on tumor cells during cultivation in 3D cultures." Medical Immunology (Russia) 26, no. 4 (2024): 657–62. http://dx.doi.org/10.15789/1563-0625-eom-16750.

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Heat shock proteins of the 70 kDa family (HSP70) are intracellular chaperones necessary for the cell to maintain protein homeostasis. In the cytosol, under normal conditions, these proteins promote the correct folding of proteins, preventing their aggregation, and are involved in protein transport and cell survival. Among the HSP70, there is a pool of stress-inducible proteins Hsp70, which significantly increases in response to a number of stress factors and facilitates cell recovery after stress. Tumor cells, unlike normal, are characterized by the ability to present Hsp70 on the surface of t

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Borcan, Florin, Ramona Carmen Albulescu, and Nicoleta Ioana Andreescu. "Modelling Study on Parameters Influencing Binding Affinity in Drug-Polyurethane Nanoparticle Assembly." Materiale Plastice 59, no. 4 (2001): 135–43. http://dx.doi.org/10.37358/mp.22.4.5632.

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Polyurethanes are widely used in different industries, as insulators, coating or adhesive agents. Several of their medical applications include various implants, artificial heart valves, surgical instruments or catheters. The versatility and biocompatibility of these polymer products lead to their application as drug or genetic material delivery systems. We aim to evaluate different parameters that affect the encapsulation efficiency of polyurethanes, using a computational approach, in order to improve the transmembrane transfer and the bioavailability of an active agent loaded inside a drug d

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Islam, Ansa, Iram Sarwar Sarwar, Azmat Ali Shah Shah, Mujahid ul Islam Islam, Humaira JAdoon JAdoon, and Attiya Bibi Bibi. "EPIDEMIOLOGICAL PROFILE AND FETO-MATERNAL OUTCOME OF TWIN PREGNANCY: A PROSPECTIVE OBSERVATIONAL STUDY." Journal of Ayub Medical College Abbottabad 36, no. 1 (2024): 68–71. https://doi.org/10.55519/jamc-01-12859.

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Background: Twin pregnancies are complex and have often been associated with various complications affecting both mother and baby. Understanding the different maternal and foetal outcomes can provide crucial insights for healthcare practitioners. The aim was to determine the maternal and foetal outcomes of twin pregnancies and understand the factors influencing these outcomes. Methods: A prospective observational study was conducted with women experiencing twin pregnancies of more than 28 weeks gestation. Patients were followed up until 7 days postnatally and the outcomes were analyzed against

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Ascenção, Kelly, Nahzli Dilek, Karim Zuhra, Katalin Módis, Toshiro Sato, and Csaba Szabo. "Sequential Accumulation of ‘Driver’ Pathway Mutations Induces the Upregulation of Hydrogen-Sulfide-Producing Enzymes in Human Colonic Epithelial Cell Organoids." Antioxidants 11, no. 9 (2022): 1823. http://dx.doi.org/10.3390/antiox11091823.

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Recently, a CRISPR-Cas9 genome-editing system was developed with introduced sequential ‘driver’ mutations in the WNT, MAPK, TGF-β, TP53 and PI3K pathways into organoids derived from normal human intestinal epithelial cells. Prior studies have demonstrated that isogenic organoids harboring mutations in the tumor suppressor genes APC, SMAD4 and TP53, as well as the oncogene KRAS, assumed more proliferative and invasive properties in vitro and in vivo. A separate body of studies implicates the role of various hydrogen sulfide (H2S)-producing enzymes in the pathogenesis of colon cancer. The curren

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Jumayev, Sherzod, Sakijan Khudayberganov, Oybek Achilov, and Munira Allamuratova. "Assessment criteria for optimization of parameters affecting to local wagon-flows at railway sites." E3S Web of Conferences 264 (2021): 05022. http://dx.doi.org/10.1051/e3sconf/202126405022.

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Various methods can be used to obtain the most reliable results in optimizing the parameters that directly affect the acceleration of the local wagon-flows at railway sites. First of all, to use these methods, it is necessary to create a multidimensional criterion for evaluating the parameters. Assessment criteria include overtime of trains at intermediate stations, excessive costs associated with the delivery of wagons, irrationality of the geographical location of freight facilities at intermediate stations, variability of hauling and carrying capacity of hauls, processing of trains at techn

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Gurba-Bryśkiewicz, Lidia, Wioleta Maruszak, Damian A. Smuga, Krzysztof Dubiel, and Maciej Wieczorek. "Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery." Biomedicines 11, no. 10 (2023): 2752. http://dx.doi.org/10.3390/biomedicines11102752.

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The successful development of nonviral delivery systems for nucleic acids has been reported extensively over the past years. Increasingly employed to improve the delivery efficiency and therapeutic efficacy of RNA are lipid nanoparticles (LNPs). Many of the various critical formulation parameters can affect the quality attributes and effectiveness of these nano-formulations. Therefore, the systematic drug development approach (QbD) and multivariate design and statistical analysis (DOE) can be very helpful and recommended for the optimization of the composition and production of RNA–LNPs. This

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Malasiya, Rahul, and Tarkeshwar P. Shukla. "Formulation development and evaluation of gastroretentive mucoadhesive tablets of glimepiride using natural polymers." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 153–59. http://dx.doi.org/10.22270/jddt.v10i4-s.4264.

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Glimepiride, a third-generation sulfonylurea is poorly soluble anti-diabetic drug. Currently, the use of natural gums and mucilage is of increasing importance in pharmaceutical formulations as valuable drug excipients. Natural plant-based materials are economic, free of side effects, biocompatible and biodegradable. The development of mucoadhesive sustained release drug delivery system is recommended in order to enhance the bioavailability. A mucoadhesive tablets were developed using the natural polymer sodium alginate and gum tragacanth. Mucoadhesion is a complex phenomenon which involves wet

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Huanbutta, Kampanart, Tanikan Sangnim, Sontaya Limmatvapirat, Jurairat Nunthanid, and Pornsak Sriamornsak. "Factors Affecting Physical Properties of Prednisolone Loaded Nanoparticles Fabricated by Eletrohydrodynamic Atomization Technique." Advanced Materials Research 1060 (December 2014): 103–6. http://dx.doi.org/10.4028/www.scientific.net/amr.1060.103.

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Recently, nanoparticulate system has been applied to deliver drug to colon because this system can increase drug absorption, prolong drug staying in gastrointestinal tract and also minimize chance of dose dumping effect. In this study, nanoparticles (NPs) developed for colonic drug delivery were fabricated via electrohydrodynamic atomization (EHDA) to find suitable formulation and preparation conditions. The NPs were prepared by dissolving prednisolone (model drug) and Eudragit® S100 (EDS100) in methanol, ethanol, isopropanol, butanol and mixtures of ethanol with purified water in various drug

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Moustafine, R. I. "Intermacromolecular interactions with Eudragit® copolymers as a new principle of the microparticulate oral drug delivery systems development." Kazan medical journal 97, no. 1 (2016): 142–47. http://dx.doi.org/10.17750/kmj2016-142.

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The main trends of combining the chemically complementary types of (meth)acrylic copolymers of pharmaceutical-grade - Eudragit® in oral microparticulate systems with modified release (spheres, granules, capsules, etc.) - and the technological methods used in their manufacture, including various types of coating (single-layer, multi-layered, combined) are considered. It is noted that the processes that control the drugs release are based on pH-dependent intermacromolecular interaction of reactive groups between a pair of opposite charged Eudragit® copolymers both inside of spherical micro-matri

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Teymuri, Benyamin, Reza Serati, Nikolaos Athanasios Anagnostopoulos, and Mehdi Rasti. "LP-MAB: Improving the Energy Efficiency of LoRaWAN Using a Reinforcement-Learning-Based Adaptive Configuration Algorithm." Sensors 23, no. 4 (2023): 2363. http://dx.doi.org/10.3390/s23042363.

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In the Internet of Things (IoT), Low-Power Wide-Area Networks (LPWANs) are designed to provide low energy consumption while maintaining a long communications’ range for End Devices (EDs). LoRa is a communication protocol that can cover a wide range with low energy consumption. To evaluate the efficiency of the LoRa Wide-Area Network (LoRaWAN), three criteria can be considered, namely, the Packet Delivery Rate (PDR), Energy Consumption (EC), and coverage area. A set of transmission parameters have to be configured to establish a communication link. These parameters can affect the data rate, noi

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Garge, Lajri Vasant, and Ravindranath Saudagar. "Ophthalmic pH Sensitive In-Situ Gel: A Review." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 682–89. http://dx.doi.org/10.22270/jddt.v9i2-s.2734.

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Ocular Drug Delivery has been a major challenging and interesting field for the pharmaceutical scientist due to unique anatomy and physiology of eye. The eye suffers from various problems like glaucoma, dry eye syndrome, keratitis, endopthalmitis, trachoma and conjunctivitis. To achieve the effective ocular therapy within the eye. An adequate amount of active ingredients must be delivered and maintained at the site of action. The conventional therapy exhibits the poor bioavailability due to the rapid precorneal drug loss. There are some static and dynamic barriers which also affect the bioavai

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Mokhirev, A. P., K. P. Rukomojnikov, P. M. Mazurkin, and N. A. Bragina. "Verification of timber carriers speed models movement depending on natural and production factors." FORESTRY BULLETIN 25, no. 2 (2021): 108–15. http://dx.doi.org/10.18698/2542-1468-2021-2-108-115.

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One of the key production parameters of the forest transport process is the speed of movement of timber carriers when removing wood from the upper warehouse. This speed determines the maximum possible volume of prepared and exported wood. Many natural and industrial factors affect the speed of a timber truck. The speed of transport depends on the traffic conditions on the roads, which are significantly complicated by adverse weather events. Scientists have identified laws in changing the speed modes of moving vehicles based on practical observations of individual road sections. To identify the

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Dsouza, Durant, and Dipasha Sharma. "Online food delivery portals during COVID-19 times: an analysis of changing consumer behavior and expectations." International Journal of Innovation Science 13, no. 2 (2020): 218–32. http://dx.doi.org/10.1108/ijis-10-2020-0184.

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Purpose This study aims to understand the consumer behavior in the context of online food delivery services that has become crucial for all the players in the market to meet their bottom line, especially given the fact that COVID-19 has altered the mindset of consumers. The current perception was addressed and analyzed to understand the trends. So, this study examined various parameters such as e-services quality, food quality (FQ), safety measures (SM), customer satisfaction (CS) and customer loyalty (CL) in correlation to each other. Design/methodology/approach An online survey was conducted

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Abhishek, Jhariya* Nazneen Dubey Shubhangi Nema Bharti Choudhary. "Formulation And Evaluation Of Emulgel For The Treatment Of Psoriasis." International Journal in Pharmaceutical Sciences 2, no. 8 (2024): 3755–71. https://doi.org/10.5281/zenodo.13371575.

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Psoriasis is chronic inflammatory skin disarray that may drastically affect the feature of life of an affected person. Emulgel is a drug delivery systems found effective in topical delivery. Mometasone is a medium-potency synthetic corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties. We used physiochemical properties of drug, and an assessment of the irrelevance to the final formulation, the chemical and physical stability of drug and compatibility of the active with potential excipients. A suitable method of analysis of drug was UV spectrophotometric. Mometaso

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Anisah, Anisah, Rizal Munadi, Yuwaldi Away, Al Bahri, and Andri Novandri. "Analysis of Multi-Node QoS in Shrimp Pond Monitoring System with Fog Computing." Sinkron 9, no. 1 (2024): 346–54. http://dx.doi.org/10.33395/sinkron.v9i1.13205.

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Most of Indonesia’s territory consists of oceans, presenting a significant potential for developing the fisheries sector. Shrimp is among Indonesia’s flagship commodities with substantial export potential. Internationally, Indonesia holds the fourth position as the largest exporter of frozen shrimp globally. However, shrimp cultivation faces various challenges, including declining water quality due to factors such as water sources and weather, which can adversely affect harvest yields. To preempt potential failures, employing smart devices and technology in shrimp cultivation offers an effecti

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Bolla, Pradeep Kumar, Bradley A. Clark, Abhishek Juluri, Hanumanth Srikanth Cheruvu, and Jwala Renukuntla. "Evaluation of Formulation Parameters on Permeation of Ibuprofen from Topical Formulations Using Strat-M® Membrane." Pharmaceutics 12, no. 2 (2020): 151. http://dx.doi.org/10.3390/pharmaceutics12020151.

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Topical drug delivery is an attractive alternative to conventional methods because of advantages such as non-invasive delivery, by-pass of first pass metabolism, and improved patient compliance. However, several factors such as skin, physicochemical properties of the drug, and vehicle characteristics influence the permeation. Within a formulation, critical factors such as concentration of drug, physical state of drug in the formulation, and organoleptic properties affect the flux across the skin. The aim of the study was to develop and investigate topical semisolid preparations (creams and gel

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Jirků, Milan, Zuzana Lhotská, Lucia Frgelecová, et al. "Helminth Interactions with Bacteria in the Host Gut Are Essential for Its Immunomodulatory Effect." Microorganisms 9, no. 2 (2021): 226. http://dx.doi.org/10.3390/microorganisms9020226.

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Colonization by the benign tapeworm, Hymenolepis diminuta, has been associated with a reduction in intestinal inflammation and changes in bacterial microbiota. However, the role of microbiota in the tapeworm anti-inflammatory effect is not yet clear, and the aim of this study was to determine whether disruption of the microflora during worm colonization can affect the course of intestinal inflammation. We added a phase for disrupting the intestinal microbiota using antibiotics to the experimental design for which we previously demonstrated the protective effect of H. diminuta. We monitored the

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