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Dissertations / Theses on the topic 'Vasodilators'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

D'Oyley, Heather M. "Vasodilators and venous tone." Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/27871.

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The objective of these experiments was to investigate the effects of various membrane receptor-mediated and receptor-independent vasodilators on the resistance and capacitance vessels of conscious, unrestrained rats by measuring mean arterial pressure (MAP) and mean circulatory filling pressure (MCFP), an index of total body venous tone. ln the first set of experiments the dose-response effects of the directly-acting vasodilators nitroglycerin, sodium nitroprusside and hydralazine were determined in intact rats as well as in rats treated with the ganglionic blocker, hexamethonium. The effects

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2

Siddons, Thomas Edward. "The use of pulsed inhaled nitric oxide in the investigation and treatment of chronic disease affecting the pulmonary circulation." Thesis, University of Sheffield, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274966.

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3

Talbot, Nicola Maria. "Metal nitrosyl and organic nitrates as novel vasodilators." Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385724.

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4

Weldon, Hazel. "The synthesis of novel nitric oxide donors as potential vasodilators." Thesis, University of Exeter, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307295.

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5

Lo, Sze-man Irene. "A comparison of the vasoactive metabolites in the interstitial space of oxidative or glycolytic muscles in anaesthetised rats /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21790838.

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6

HYNES, MICHAEL RAY. "ENDOTHELIUM-DEPENDENT RELAXATION OF BLOOD VESSELS." Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184134.

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Dilation of blood vessels in response to a large number of agents has been shown to be dependent on an intact vascular endothelium. The present studies examine some aspects of endothelium-dependent vasodilation in blood vessels of the rabbit and rat. Using the rabbit ear artery and the subtype-selective muscarinic antagonist pirenzepine, muscarinic receptors of the endothelium and smooth muscle cells were shown to be of the low affinity M₂ subtype. Inhibition of [³H](-)quinuclidinyl benzilate was used to determine affinity for the smooth muscle receptors while antagonism of methacholine induce

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7

Reeves, Katherine Ann. "The cardiovascular actions of the isopropyl ester and other synthetic derivatives of palmitoyl carnitine." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.260252.

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8

Joseph, Emlyn Clive. "Pathogenesis of arteriopathy induced by PDE III inhibitors in the rat and dog." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307684.

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9

Firkin, Catherine R. "A biomimetic approach to the synthesis of xestospongin A." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389208.

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10

羅詩敏 and Sze-man Irene Lo. "A comparison of the vasoactive metabolites in the interstitial space of oxidative or glycolytic muscles in anaesthetised rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31223138.

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11

Wier, S. W. "A study of the action of some vasodilators in the rat and guinea-pig." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374572.

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12

McLeod, Janet Leigh, and janet mcleod@deakin edu au. "The natriuretic peptides and their receptors in the brain of the amphibian, Bufo marinus." Deakin University. School of Biological and Chemical Sciences, 1999. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20071024.112730.

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The natriuretic peptides, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP) are members of a family of hormones that play an important role in mammalian fluid and electrolyte balance. In the periphery, natriuretic peptides reduce blood volume and subsequently blood pressure by increasing renal natriuresis and diuresis and relaxation of vascular smooth muscle. The actions of natriuretic peptides are mediated via two membrane-linked guanylate cyclase receptors (NPR-GC); natriuretic peptide receptor-A (NPR-A) which has a high affinity for ANP a

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13

Heeneman, Sylvia. "Structural alterations in peripheral arteries during experimental heart failure opposing effects of vasoconstrictors and vasodilators /." Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 1997. http://arno.unimaas.nl/show.cgi?fid=5813.

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14

Finch, Michael Brendan. "Haemodynamic effects of some peripheral vasodilators in normal man and in patients with Reynauds's syndrome." Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328044.

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15

Schrage, William. "Effects of hindlimb unweighting on soleus muscle resistance artery endothelial function and eNOS expression." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3013020.

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16

Yin, Ning [Verfasser]. "Inhaled vasodilators as a new treatment strategy in pulmonary hypertension with left heart disease / Ning Yin." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023580365/34.

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17

Tsoporis, Jim. "Effects of arterial vasodilators on cardiovascular hypertrophy and sympathetic activity in normotensive Wistar and spontaneously hypertensive rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ66241.pdf.

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18

Gómez, Ortiz Edna Mireya [UNESP]. "Avaliação cardíaca de cães com degeneração valvar mixomatosa durante o emprego de enalapril, losartana, furosemida e suas combinações." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/89198.

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Made available in DSpace on 2014-06-11T19:23:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2011-02-22Bitstream added on 2014-06-13T20:11:36Z : No. of bitstreams: 1 gomezortiz_em_me_jabo.pdf: 655486 bytes, checksum: c6735fb13135ba2645745a2e60a3ec5e (MD5)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>A degeneração valvar mixomatosa (DVM) é a afecção cardíaca mais comum em cães. O tratamento da insuficiência cardíaca congestiva (ICC) decorrente da DVM baseia-se no uso de inibidores da enzima conversora de angiotensina - ECA. Antagonistas dos receptores de ang

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19

Wathen, Christopher George. "Studies of the cardiovascular effects of inotropic agents and vasodilators on the pulmonary and systemic circulation in man." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/27032.

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20

Gomez, Ortiz Edna Mireya. "Avaliação cardíaca de cães com degeneração valvar mixomatosa durante o emprego de enalapril, losartana, furosemida e suas combinações /." Jaboticabal : [s.n.], 2011. http://hdl.handle.net/11449/89198.

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Orientador: Aparecido Antonio Camacho<br>Banca: Mirela Tinucci Costa<br>Banca: Wagner Luis Ferreira<br>Resumo: A degeneração valvar mixomatosa (DVM) é a afecção cardíaca mais comum em cães. O tratamento da insuficiência cardíaca congestiva (ICC) decorrente da DVM baseia-se no uso de inibidores da enzima conversora de angiotensina - ECA. Antagonistas dos receptores de angiotensina II - ARAs promovem o bloqueio completo da angiotensina II, e são usados no tratamento de ICC em humanos, mas não é comum em cães. O objetivo desta pesquisa foi comparar as respostas clínicas de cães com DVM tratados c

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21

Kulczynska, Agnieszka. "N-hydroxyguanidines and related compounds as nitric oxide donors." Thesis, University of St Andrews, 2009. http://hdl.handle.net/10023/957.

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The design of new, improved NO-donor drugs is an important pharmacological objective due to the biological importance of nitric oxide. N-Hydroxyguanidines represent a useful class of NO donors where the mechanism of action is based on the biosynthetic pathway for NO. Thirty new N-arylalkyl-N’-hydroxyguanidines were synthesized and their vasodilatation activity examined by myography in rat aortic rings. The observed relaxations were reversed by ODQ, which is an inhibitor of the guanylate cyclase, implying that this was an NO dependent vasodilatation. The most active compounds were also tested i

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22

Lunkes, Daniéle Sausen. "Interferência de vasodilatadores na hidrólise de nucleotídeos da adenina em plaquetas de pacientes hipertensos." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/11097.

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The thrombogenic process that affects the hypertensive patient is associated with regulatory mechanisms present in the vascular endothelium. These mechanisms involve the release of a endothelium-derived relaxing factor, ectonucleotidases and calcium ions. Considering that vasodilators act both on blood pressure and on homeostasis, we evaluated the interference of different vasodilators on platelet NTPDase activity in hypertensive and healthy patients, with the objective of verifying patient sensitivity to vasodilators. In addition, the kinetic behavior of NTPDase was determined in the presence

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23

Mauro, Maria Fernanda Zuliani. "Análise volumétrica da hiperplasia intimal intra-stent farmacológico em pacientes diabéticos tratados com ou sem cilostazol." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/98/98131/tde-04102013-090756/.

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Fundamentos: Ensaios prévios reunindo pacientes em series consecutivas ou randomicas sem cegamento evidenciaram beneficio da adição do cilostozol à terapia antiplaquetária em diabéticos submetidos ao implante de stents coronários farmacológicos com redução nas taxas de reestenose binária, perda tardia intra-stent e revascularização tardia da lesão alvo. Objetivos: O objetivo primário deste estudo foi verificar se a adição do cilostazol à dupla terapia antiplaquetária, proporcionaria uma redução adicional da hiperplasia intimal em diabéticos após o implante de stent farmacológico, mensurada por

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24

Cunha, Patrícia Santos. "Efeito vasorelaxante dos isômeros (+) e (-)-linalol em artéria mesentérica de rato." Pós-Graduação em Ciências Fisiológicas, 2013. https://ri.ufs.br/handle/riufs/3972.

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Linalool is a monoterpene can be biosynthesized by some plants in the racemic form, ( })-linalool, or in the form of enantiomers, (+)-linalool or (-)-linalool. The evaluation the activity of pure isomers has become important in the discovery of new drugs with improved therapeutic potential and a lower rate of adverse effects. So, the objective of the present study was to evaluate the vasorelaxant action induced by the enantiomers, (+) and (-)-linalool in rat superior mesenteric artery, besides seeks to elucidate the mechanisms of action involved in this effect. For both, male Wistar rats (200

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25

Martorana, M. G. "Vasodilator aspects of some cardiac inotropic agents." Thesis, University of Strathclyde, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372098.

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26

McGinn, Jennifer Sarah. "The vasodilatory and antioxidant activities of polyphenolic substances." Thesis, University of Glasgow, 2002. http://theses.gla.ac.uk/1583/.

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This project was designed to determine the effect of a wide range of grape and tea based extracts and green tea catechins on vascular tension in vitro, further determine the relationship between their vasodilatory and antioxidant activities and identify the major polyphenols present in green and black tea. Grape and tea based extracts were examined for their vasodilator activity in vitro using standard organ bath pharmacology. All extracts evoked biphasic concentration-dependent relaxation in rabbit aortic vessels. Grape based extracts were significantly better vasodilators than tea based extr

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27

Reis, Lais Vissotto Garchet Santos. "Efeito da cafeína na detecção de isquemia à cintilografia de perfusão miocárdica associada ao estresse com adenosina." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-01022011-162926/.

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A utilização da cintilografia de perfusão miocárdica (CPM) estava limitada a pacientes que podiam realizar algum tipo de exercício, para ampliarmos a disponibilidade clínica da CPM, vários protocolos com estresses farmacológicos foram desenvolvidos. A adenosina fármaco amplamente utilizado, potente vasodilatador coronariano, apresenta uma importante interação com outras substâncias que anatagonizam seus efeitos, o dipiridamol, alimentos com cafeína e derivados de xantinas. O tempo de suspensão de cafeína da dieta para o uso exógeno da adenosina na realização da CPM ainda não está definido. Par

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28

Shi, Yun. "KATP Channel Phosphorylation: Mechanisms and Contribution to Vascular Tone Regulation by Vasodilating and Vasoconstricting Hormones and Neurotransmitters." unrestricted, 2007. http://etd.gsu.edu/theses/available/etd-11302007-150810/.

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Thesis (Ph. D.)--Georgia State University, 2007.<br>Title from file title page. Chun Jiang, committee chair; Teryl Frey, Deborah Baro, Delon Barfuss, committee members. Electronic text (168 p. : ill. (some col.)) : digital, PDF file. Description based on contents viewed Jan. 30, 2008. Includes bibliographical references (p. 146-151).

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29

Drake, W. M. "Desensitisation of calcitonin gene-related peptide of adrenomedullin receptors in vascular smooth muscle of SK-N-MC cells." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275192.

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30

Barker, Diana May. "Investigations of the vasodilator actions of corticotrophin-releasing factor." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299182.

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31

Abu-Kishk, Rabee Awni. "Vasodilator mechanisms and the intracellular control of renin secretion." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292931.

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32

Stride, Ann Elizabeth. "Mechanisms underlying the metabolic and vasodilator effects of insulin." Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4297/.

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Insulin causes uptake of glucose into cells and also causes increases in skeletal muscle blood flow by vasodilatation. In order for insulin to act at receptors on the skeletal muscle membrane, it must move through the capillary endothelium. In conditions associated with insulin resistance, insulin-induced glucose uptake and vasodilatation are often blunted and disordered transport across endothelium has been suggested. Firstly, studies were conducted using the hyperinsulinaemic euglycaemic (HE) clamp in rats to assess the relationship between insulin-induced muscle vasodilatation and glucose u

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33

Love, Alastair I. "Factors affecting nerve regeneration and function in experimental diabetes." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241877.

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Rats with streptozotocin-induced diabetes exhibit both a reduction in nerve conduction velocity (NCV) and an impaired regenerative response after nerve injury. Nerve blood flow is also reduced in diabetic rats. Vasodilator treatment normalized the deficit in maximum regeneration distance after nerve injury. This strongly suggests a role for endoneurial hypoxia in the impaired regenerative response associated with diabetes. Inhibition of polyol pathway hyperactivity in diabetic rats corrects the deficit in nerve regeneration. Compensation for impaired essential fatty acid metabolism with evenin

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34

Al-Hamidi, Abdulaziz Abdullah Abdulrahman. "Purification and characterization of prokallikrein from bovine pancreas." Thesis, University of Essex, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278522.

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35

Yang, Yang. "Vascular KATP Channel Modulation by S-Glutathionylation: A Novel Mechanism for Cellular Response to Oxidative Stress." Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/biology_diss/97.

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The KATP channels play an important role in the membrane excitability and vascular tone regulation. Previous studies indicate that the function of KATP channels is disrupted in oxidative stress seen in a variety of cardiovascular diseases, while the underlying mechanism remains unclear. Here, we demonstrate S-glutathionylation to be a modulation mechanism underlying the oxidant-mediated vascular KATP channel inhibition, the molecular basis for the channel inhibition and the alleviation of the channel inhibition by vasoactive intestinal peptide (VIP). We found that an exposure of isolated mesen

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36

Crail, Susan Margaret. "Studies of the function and regulation of vasodilator-stimulated phosphoprotein." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433088.

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37

Southerton, J. S. "Studies on the mechanisms of action of some smooth muscle relaxants." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237287.

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38

Patel, Hanif M. S. "Studies on the nitrosation of thiols in relation to vasodilatory action." Thesis, Durham University, 1989. http://etheses.dur.ac.uk/6728/.

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A kinetic study of the nitrosation of L-cysteine, L-cysteine methyl and ethyl esters, N-acetyl-L-cysteine and glutathione by isopropyl nitrite in acid solution at 25 C was undertaken. The thiols exhibited identical rate laws and in all cases the observed rate constant was reduced by added isopropyl alcohol. The results were found to be consistent with the mechanism in which a rapid reversible acid-catalysed hydrolysis of isopropyl nitrite occurs to give nitrous acid, which then in its protonated form effects nitrosation. The third-order rate constant for the nitrosation of the thiols by isopro

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39

Sletten, Nathan Robert. "Effects of high-intensity interval exercise on vasodilator function in children." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/62809.

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Purpose: Exercise training can improve vascular function through anti-atherogenic effects on the vascular endothelium, a response which can be discerned following individual bouts of exercise. Although well characterized in adults, the effect of exercise intensity on the acute recovery patterns of vasodilator function is unknown in children. Study Design: Nine children (age = 10.5 ± 1.5 y, 6 girls) completed 1) high-intensity interval exercise (HIIE, six 1-minute sprints at 90% peak power (Wmax), with 1-minute recovery) and 2) moderate-intensity exercise (MIE, 15 minutes at 44% Wmax, total ext

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40

Price, Caroline J. "Molecular interactions and cellular functions of the vasodilator stimulated phosphoprotein (VASP)." Thesis, University of Leicester, 2000. http://hdl.handle.net/2381/29350.

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The vasodilator stimulated phosphoprotein (VASP) is associated with focal adhesions, actin microfilaments and regions of highly dynamic membrane activity in cells. VASP binds to the G-actin-binding protein profilin which regulates actin polymerisation. It also binds to the Listeria monocytogenes surface protein Act A and recruits profilin to the bacterial surface, thereby promoting efficient actin polymerisation for movement of the bacteria. It has been postulated that a cellular homologue of the Act A protein may exist which recruits VASP to cell membrane surfaces. Here, binding of VASP to a

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41

Turcato, Sally. "The role of cyclic AMP and Kâº channels in mediating vasorelaxation induced by prostacyclin analogues and other Gs-coupled receptors." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342235.

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42

Sadigh, Bita. "Analgetic and algetic effects of adenosine in healthy volunteers and patients with coronary artery disease /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-382-5/.

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43

Stewart, Derek C. "Implementing formulary recommendations in primary care : effect on patient outcomes." Thesis, Robert Gordon University, 1998. http://hdl.handle.net/10059/615.

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This research aimed to measure the effect on health outcomes of implementing selected recommendations of the Grampian Joint Drug Formulary in primary care. Antibiotics used in the treatment of uncomplicated lower urinary tract infections (UTIs), ulcer healing agents and peripheral vasodilators were selected for study, thereby reflecting both acute and chronic prescribing. For the UTI study, 12 randomly selected high and low prescribers of trimethoprim, the recommended agent, each agreed to distribute 20 patient questionnaires. Following a period of 18 months and despite repeated contact with t

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44

Dawes, Matthew. "Drug-induced vasodilation in human forearm resistance vasculature." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342326.

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45

Gitlin, Jonathan Max. "Endogenous vasodilator pathways : their interactions and relevance to the vascular effects of ATP." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271969.

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46

Demoncheaux, Eric Arthur Germain. "Physico-chemical properties of nitrogen monoxide : implication for its role as a vasodilator." Thesis, Anglia Ruskin University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264045.

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47

Coppock, Hedley Alan. "Investigation of the receptors and mechanisms of action of the novel vasodilator peptide, adrenomedullin." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327028.

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48

Sugita, Kenichiro, Masato Shibuya, Masakazu Takayasu, et al. "Role of Nitric Oxide in the Cerebral Vasodilatory Responses to Vasopressin and Oxytocin in Dogs." Thesis, Nature Publishing Group, 1993. http://hdl.handle.net/2237/16711.

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49

Lovell, Sharon Lynne. "The role of nitric oxide and endothelin in the regulation of pulmonary arterial pressure in man." Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322648.

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50

Södergren, Anna. "VASODILATORY EFFECTS OF EXOGENOUS NITRIC OXIDE ON THE BROOD PATCH OF THE ZEBRA FINCH (Taeniopygia guttata)." Thesis, Linköping University, Department of Physics, Chemistry and Biology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-56855.

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<p>In birds like the Zebra finch (Taeniopygia guttata) the female, but not the male develop a brood patch upon incubation of eggs. The brood patch functions to increase heat exchange between the bird and the eggs. Development of the brood patch includes de-feathering, increased vascularization and edema formation. The increased vascularization is due to the development of arteriovenous anastomoses, AVA. The AVA are thermoregulatory vessels involved in cold induced vasodilation, CIVD, demonstrated to occur in the brood patch. Nitric oxide, NO, which is a well known vasodilator is a candidate su

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