Relevant bibliographies by topics / Viability of organs as well as tissues

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Viability of organs as well as tissues'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Viability of organs as well as tissues"

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Sobko, I. V. "The use of infrared thermography for abdominal gunshot wounds." Zaporozhye Medical Journal 26, no. 3 (2024): 258–64. http://dx.doi.org/10.14739/2310-1210.2024.3.298580.

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Aim. To determine the effectiveness of infrared thermography to identify tissue debris of parenchymal organs and in the wound edges of hollow organs to be removed as well as for the surgical treatment of gunshot wounds of the anterior abdominal wall. Materials and methods. The results of the infrared thermography use in the provision of surgical care to 67 wounded at the second level of medical care in the conditions of the Forward Surgical Group of the Military Mobile Hospital were analyzed. Results. Clinical examples and results of the infrared thermography use for the diagnosis and treatmen
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Kumar, Manav Sree, Payal Varma, and Balasubramanian Kandasubramanian. "From lab to life: advances in in-situ bioprinting and bioink technology." Biomedical Materials 20, no. 1 (2024): 012004. https://doi.org/10.1088/1748-605x/ad9dd0.

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Abstract Bioprinting has the potential to revolutionize tissue engineering and regenerative medicine, offering innovative solutions for complex medical challenges and addressing unmet clinical needs. However, traditional in vitro bioprinting techniques face significant limitations, including difficulties in fabricating and implanting scaffolds with irregular shapes, as well as limited accessibility for rapid clinical application. To overcome these challenges, in-situ bioprinting has emerged as a groundbreaking approach that enables the direct deposition of cells, biomaterials, and bioactive fa
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Ostróżka-Cieślik, Aneta. "The Effect of Antioxidant Added to Preservation Solution on the Protection of Kidneys before Transplantation." International Journal of Molecular Sciences 23, no. 6 (2022): 3141. http://dx.doi.org/10.3390/ijms23063141.

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Ischemia–reperfusion injury is a key clinical problem of transplantology. Current achievements in optimizing organ rinse solutions and storage techniques have significantly influenced the degree of graft damage and its survival after transplantation. In recent years, intensive research has been carried out to maintain the viability of tissues and organs outside the integral environment of the body. Innovative solutions for improving the biochemical functions of the stored organ have been developed. The article discusses directions for modifying preservation solutions with antioxidants. Clinica
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Panconesi, Rebecca, Mauricio Flores Carvalho, Matteo Mueller, et al. "Viability Assessment in Liver Transplantation—What Is the Impact of Dynamic Organ Preservation?" Biomedicines 9, no. 2 (2021): 161. http://dx.doi.org/10.3390/biomedicines9020161.

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Based on the continuous increase of donor risk, with a majority of organs classified as marginal, quality assessment and prediction of liver function is of utmost importance. This is also caused by the notoriously lack of effective replacement of a failing liver by a device or intensive care treatment. While various parameters of liver function and injury are well-known from clinical practice, the majority of specific tests require prolonged diagnostic time and are more difficult to assess ex situ. In addition, viability assessment of procured organs needs time, because the development of the
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Gubareva, E. A., E. V. Kuevda, A. Kh Kade, et al. "Quality assessment of decellularization and recellularization of tissue-engineering constructions by the chemiluminescence method." Доклады Академии наук 484, no. 6 (2019): 764–67. http://dx.doi.org/10.31857/s0869-56524846764-767.

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It has been established that indicators of the intensity of chemiluminescence in the native and muscle cellized tissues of rat muscular organs, as well as in their decellularized matrices, can serve as one of the express criteria that allows, along with ultrastructural analysis, to quantify the viability of cell structures in biological samples of the diaphragm.
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Glyantsev, S. P. "Condition of the problem of organ transplantation in the USSR in 1970–1971 and ways to solve it (Yu.M. Lopukhin, A.G. Lapchinsky, V.P. Demikhov)." Transplantologiya. The Russian Journal of Transplantation 15, no. 4 (2023): 541–58. http://dx.doi.org/10.23873/2074-0506-2023-15-4-541-558.

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Aim. The article examines and analyzes the state of the problem of organ transplantation in the USSR in the early 1970s and ways to solve it with the participation of three prominent transplantologists of the Soviet Union – Yu.M. Lopukhin, A.G. Lapchinsky and V.P. Demikhov, as well as some world achievements in this field.Material and methods. Available printed works on the history of Russian and world transplantology in the 1970s, the analysis of which was carried out by historical-genetic and comparative-analytical methods.Results. Developed by Yu.M. Lopukhin together with leading surgeons a
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Tran, Douglas, John Vandenberge, Nancy Kim, Zhongjun Wu, and Bartley Griffith. "431 Allogeneic recellularized lung orthotopic (ARLO) transplant research: A short-term non-survival model." Journal of Clinical and Translational Science 9, s1 (2025): 129. https://doi.org/10.1017/cts.2024.1036.

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Objectives/Goals: This study assesses the feasibility of a human-to-swine lung transplant model for the evaluation of bioengineered organs. Given the critical organ shortage, this research explores bioengineered organs as a potential solution by evaluating early lung function, immune responses, and technical aspects to develop a model for bioengineered lungs. Methods/Study Population: The study employs a non-survival human-to-swine left lung transplant model in an immunosuppressed Yorkshire swine. A combination of cobra venom factor pretreated with methylprednisolone and Benadryl with schedule
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Atia, Gamal Abdel Nasser, Hany K. Shalaby, Naema Goda Ali, et al. "New Challenges and Prospective Applications of Three-Dimensional Bioactive Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review." Pharmaceuticals 16, no. 5 (2023): 702. http://dx.doi.org/10.3390/ph16050702.

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Regenerative medicine, and dentistry offers enormous potential for enhancing treatment results and has been fueled by bioengineering breakthroughs over the previous few decades. Bioengineered tissues and constructing functional structures capable of healing, maintaining, and regenerating damaged tissues and organs have had a broad influence on medicine and dentistry. Approaches for combining bioinspired materials, cells, and therapeutic chemicals are critical in stimulating tissue regeneration or as medicinal systems. Because of its capacity to maintain an unique 3D form, offer physical stabil
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Pospelov, Anton D., Olga M. Kutova, Yuri M. Efremov, et al. "Breast Cancer Cell Type and Biomechanical Properties of Decellularized Mouse Organs Drives Tumor Cell Colonization." Cells 12, no. 16 (2023): 2030. http://dx.doi.org/10.3390/cells12162030.

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Tissue engineering has emerged as an indispensable tool for the reconstruction of organ-specific environments. Organ-derived extracellular matrices (ECM) and, especially, decellularized tissues (DCL) are recognized as the most successful biomaterials in regenerative medicine, as DCL preserves the most essential organ-specific ECM properties such as composition alongside biomechanics characterized by stiffness and porosity. Expansion of the DCL technology to cancer biology research, drug development, and nanomedicine is pending refinement of the existing DCL protocols whose reproducibility rema
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Biru, Elena Iuliana, Madalina Ioana Necolau, Adriana Zainea, and Horia Iovu. "Graphene Oxide–Protein-Based Scaffolds for Tissue Engineering: Recent Advances and Applications." Polymers 14, no. 5 (2022): 1032. http://dx.doi.org/10.3390/polym14051032.

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The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. This review critically focuses on opportunities to employ protein–graphene oxide structures either as nanocomposites or as biocompl
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Dissertations / Theses on the topic "Viability of organs as well as tissues"

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Brites, Alice Dantas. "Monitoramento dos efeitos ecológicos e socioeconômicos da comercialização de produtos florestais não madereiros." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/90/90131/tde-24032011-215203/.

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A comercialização de produtos florestais não madeireiros (PFNMs) popularizou-se como atividade promotora do desenvolvimento socioeconômico de comunidades florestais com baixo impacto ambiental. Há evidências, contudo, de que a exploração possa produzir efeitos ecológicos e socioeconômicos negativos, sugerindo que é necessário monitorar tais iniciativas. A comercialização frequentemente ocorre em áreas remotas e em contextos de pobreza, como é o caso de muitas daquelas da Amazônia brasileira. Desta forma, é necessário que o monitoramento restrinja-se a avaliar os efeitos evidenciados como mais
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Naidoo, Prabashni. "Development of explants potentially suitable for cryopreservation of the recalcitrant-seeded species Theobroma cacao L. and Barringtonia racemosa (L.) roxb." Thesis, 2008. http://hdl.handle.net/10413/1179.

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The two species investigated in this study were Theobroma cacao and Barringtonia racemosa. Theobroma cacao has worldwide economic importance, as cocoa (the main ingredient in chocolate) is produced from the seeds of this tree; while B. racemosa has several applications in herbal medicine. The seeds of both T. cacao and B. racemosa are highly recalcitrant and therefore not amenable to storage for any significant periods. The long-term conservation of the germplasm of these species may only be feasible via cryopreservation. The aims of the present study were to: 1) optimize in vitro regeneration
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Books on the topic "Viability of organs as well as tissues"

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Yoshio, Yamaoka, ed. Living related donor liver transplantation: Assessment of graft viability based on the redox theory. Karger, 1994.

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Marzok, Mohamed Ahmed Tony Ahmed. Detection of genetically modified soybeans and maize in Egypt as well as comparative nutritional safety investigations of isogenic and transgenic (Bt) maize in broiler nutrition: Broiler performance, degradation and metabolic fate of maize DNA in some tissues and organs. Mensch & Buch Verlag, 2004.

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Mohamed Ahmed Tony Ahmed Marzok. Detection of genetically modified soybeans and maize in Egypt as well as comparative nutritional safety investigations of isogenic and transgenic (Bt) maize in broiler nutrition: Broiler performance, degradation and metabolic fate of maize DNA in some tissues and organs. Mensch & Buch Verlag, 2004.

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Bykov, Yuri, Roman Bekker, and Mikhail Grigoriev. PEPTIDOLOGY, PEPTIDOMICS AND PEPTIDE MEDICINE — HISTORY AND PERSPECTIVES. Publishing Center RIOR, 2024. http://dx.doi.org/10.29039/02144-6.

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The book is devoted to both history and modern theory and practice of medical and veterinary use of peptides, their isolation in pure form, their laboratory chemical synthesis, as well as history of the study of the properties of various peptide substances. First it were extracts or hydrolysates from animal tissues and organs. Later it were pure peptide hormones and mediators, cytokines, antibiotics, etc. The book is intended primarily for students who are in the process of getting higher medical education in the disciplines “General Medicine”, “Pediatrics”, “Pharmacy”, “Medical Biochemistry”,
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Tyukavin, Aleksandr, Andrey Vasil'ev, Nikolay Arseniev, et al. Physiology with the basics of anatomy. INFRA-M Academic Publishing LLC., 2023. http://dx.doi.org/10.12737/1904329.

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The textbook presents modern ideas about the structure and functions of the human body in accordance with the curriculum of the discipline "Physiology with the basics of anatomy".
 The morphofunctional features of living systems and basic physiological processes that manifest themselves at the level of cells, tissues, organs and the body as a whole are highlighted. The main genomic and epigenomic mechanisms of regulation of intracellular processes, as well as molecular mechanisms of adaptation of cells to the action of environmental factors are presented. The structure and precision neuro
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Yang, Jingduan, and Daniel A. Monti. Physiology of the Internal Organs. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190210052.003.0004.

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This chapter provides a detailed description of the concepts of internal human organs from a Chinese medicine perspective, including two additional organs: Pericardium and San Jiao (cavities of chest, abdomen, and pelvic). It describes in detail the manifestation (Xiang) of physiological functions of solid organs (Zang) such as the Heart, Liver, Lungs, Spleen, Kidneys, and Pericardium, and hollow organs (Fu) such as Small Intestine, Larger Intestine, Gallbladder, Bladder, Stomach, and San Jiao. It teaches the functions that overlap largely with modern medical physiology as well as the addition
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van der Burg, Jorien M. M., N. Ahmad Aziz, and Maria Björkqvist. Peripheral Pathology. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199929146.003.0014.

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Clinicians and researchers have previously focused on the neurologic and psychiatric aspects of Huntington’s disease (HD). However, it is becoming evident that many neurodegenerative disorders are also complicated by pathology in tissues outside the brain. Although many clinical features of HD can be ascribed to neuronal loss and dysfunction, there is accumulating evidence indicating a role for the pathology of non-neuronal tissues in the disease process. Mutant huntingtin is expressed throughout the body and may induce pathology in parallel in both the brain and other organs. Insights into pe
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Burton, Derek, and Margaret Burton. Integration and control: hormones. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198785552.003.0010.

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Fish, and other vertebrates, possess both a neural control system and a hormonal one dependent on the circulation. Fish hormones may be secreted by well-defined endocrine glands or by diffuse tissue and can have profound effects on the function of target tissues or organs which possess receptor molecules recognized by specific hormones. Some endocrine activities in fish are not relevant to mammals, and vice versa. Thus fish can have chromatophores controlled hormonally to change skin colour, the same hormones having different roles in mammals. Likewise, ‘prolactin’ in fish cannot regulate lact
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Microplastics and Fertility. Exon Publications, 2024. https://doi.org/10.36255/microplastics-fertility.

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Microplastics and Fertility explores the impact of microplastics on human reproductive health, highlighting their potential to disrupt male and female fertility.The article begins with an abstract that provides a brief overview of how microplastics infiltrate human tissues and the risks they pose to reproductive health. The introduction outlines the growing problem of plastic pollution and its connection to fertility decline. It explains how microplastics enter the human body through ingestion, inhalation, and skin contact, allowing them to accumulate in vital organs and reproductive tissues.
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O’Connell, Sue. Lyme borreliosis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0009.

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Lyme borreliosis is the most common vector-borne bacterial infection in the temperate northern hemisphere. In the United States of America over 35,000 confirmed or probable cases were reported by state health departments to the Centers for Disease Control and Prevention (CDC) in 2008. It is likely that well over 100,000 cases occur in Europe each year. Lyme borreliosis is caused by several genospecies of Borrelia burgdorferi sensu lato, which are transmitted by ticks of the Ixodes ricinus complex. The infection occurs most commonly in forested, woodland and heathland habitats that support the
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Book chapters on the topic "Viability of organs as well as tissues"

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Sminia, Peter, Olivier Guipaud, Kristina Viktorsson, et al. "Clinical Radiobiology for Radiation Oncology." In Radiobiology Textbook. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-18810-7_5.

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AbstractThis chapter is focused on radiobiological aspects at the molecular, cellular, and tissue level which are relevant for the clinical use of ionizing radiation (IR) in cancer therapy. For radiation oncology, it is critical to find a balance, i.e., the therapeutic window, between the probability of tumor control and the probability of side effects caused by radiation injury to the healthy tissues and organs. An overview is given about modern precision radiotherapy (RT) techniques, which allow optimal sparing of healthy tissues. Biological factors determining the width of the therapeutic w
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Ahire, Vidhula, Niloefar Ahmadi Bidakhvidi, Tom Boterberg, et al. "Radiobiology of Combining Radiotherapy with Other Cancer Treatment Modalities." In Radiobiology Textbook. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-18810-7_6.

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AbstractIn this chapter, we address the role of radiation as treatment modality in the context of oncological treatments given to patients. Physical aspects of the use of ionizing radiation (IR)—by either photons, neutrons, or charged (high linear energy transfer) particles—and their clinical application are summarized. Information is also provided regarding the radiobiological rationale of the use of conventional fractionation as well as alternative fractionation schedules using deviating total dose, fraction size, number of fractions, and the overall treatment time. Pro- and contra arguments
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Wallhult, Elisabeth, Michelle Kenyon, and Barry Quinn. "Early and Acute Complications and the Principles of HSCT Nursing Care." In The European Blood and Marrow Transplantation Textbook for Nurses. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-23394-4_10.

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AbstractHaematopoietic stem cell transplantation (HSCT) generally includes preparative or conditioning regimens containing combinations of chemotherapy and/or radiotherapy and sometimes immunotherapy. These regimens, as well as other treatments before and after HSCT such as immunosuppressive drugs to prevent graft-versus-host disease (GvHD) (see Chap. 11), may affect the patient’s organs and tissues and cause both early and long-term complications. In the evolving field of stem cell therapies, some complications that traditionally have been regarded as early complications are now, due to chang
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Svoren, Martin, Elena Camerini, Merijn van Erp, Feng Wei Yang, Gert-Jan Bakker, and Katarina Wolf. "Approaches to Determine Nuclear Shape in Cells During Migration Through Collagen Matrices." In Cell Migration in Three Dimensions. Springer US, 2023. http://dx.doi.org/10.1007/978-1-0716-2887-4_7.

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AbstractFibrillar collagen is an abundant extracellular matrix (ECM) component of interstitial tissues which supports the structure of many organs, including the skin and breast. Many different physiological processes, but also pathological processes such as metastatic cancer invasion, involve interstitial cell migration. Often, cell movement takes place through small ECM gaps and pores and depends upon the ability of the cell and its stiff nucleus to deform. Such nuclear deformation during cell migration may impact nuclear integrity, such as of chromatin or the nuclear envelope, and therefore
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Morton, Timothy. "Objects as Temporary Autonomous Zones." In continent. Year 1. punctum books, 2012. https://doi.org/10.21983/p3.0016.1.10.

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Autonomy means that although something is part of something else, or related to it in some way, it has its own “law” or “tendency” (Greek, no-mos). In their book on life sciences, Medawar and Medawar state, “Organs and tissues [...] are composed of cells which [...] have a high measure of autonomy.” Autonomy also has ethical and political valences. De Grazia writes, “In Kant’s enormously influential moral philosophy, autonomy, or free-dom from the causal determinism of nature, became prominent in justifying the human use of animals.” One of the oldest uses of autonomy in English is a descripti
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Katiyar, Soumya, Shikha Kumari, Ritika Singh, et al. "Recent Advances in the Application of Nano-Biosensor in Tissue Engineering." In Recent Advances in Biosensor Technology. BENTHAM SCIENCE PUBLISHERS, 2023. http://dx.doi.org/10.2174/9789815123739123010009.

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Nanotechnology has a profound influence on environmental research, infrastructure, energy, food standards, information technology, and medicine. In biomedicine, nanotechnology primarily aims to provide solutions for preventive care, diagnosis, and therapy. Biosensors have significantly revolutionized the medical sector by offering on-site diagnostic capabilities. Since 1962, the combination of biosensors with nanotechnology has made a significant contribution to therapeutics and tissue engineering. Biosensors are diagnostic devices that monitor biochemical interactions and translate them into
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Şahin, Fikrettin, Batuhan Turhan Bozkurt, Derya Sağraç, et al. "Rejeneratif Biyoloji ve Kök Hücre Uygulamaları." In Moleküler Biyoloji ve Genetik. Türkiye Bilimler Akademisi, 2023. http://dx.doi.org/10.53478/tuba.978-625-8352-48-1.ch22.

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Regenerative medicine is the field of returning tissues or organs that lost their function due to aging or illness to a healthy status. It entails the use of stem cells, biocompatable scaffolds, and agents that modulate cellular viability, such as cytokines. This chapter will cover the purpose and the scope of regenerative medicine, the applications of stem cells, tissue engineering and other in regenerative medicine, and their clinical applications.
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Fortune, Farida. "Endocrine disorders and disorders of bone metabolism." In Human disease for dentistry. Oxford University PressNew York, NY, 2004. http://dx.doi.org/10.1093/oso/9780192631633.003.0014.

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Abstract The pituitary gland produces hormones which regulate the function of the endocrine organs such as the thyroid gland, the adrenal cortex, the breast, and the gonads, as well as targeting non-endocrine organs and tissues. Each pitu- itary hormone is regulated by hypothalamic-derived substances as well as regulated in a negative-feedback loop by substances produced by its target organs. Negative feedback occurs at both hypothalamic and pituitary levels.
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Ma, Qing-Ping. "Toward Eradicating All Diseases." In Advances in Human and Social Aspects of Technology. IGI Global, 2021. http://dx.doi.org/10.4018/978-1-7998-6772-2.ch014.

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Progress in biomedical sciences and engineering will take mankind closer to a world without disease. The objective of this chapter is to review and forecast research and technologies that contribute to eliminating all diseases. In addition to improved traditional therapeutics such as medicinal chemicals, antibiotics, vaccines, and antibodies, DNA and RNA therapeutics will play key roles in addressing genetic, infectious, and chronic diseases by decreasing disease facilitating proteins or increasing disease suppressing proteins. Nanorobots will find and treat thrombosis and vascular stenosis ca
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K, Dr Jai Kiran, and Dr Manjusha D. "SCAFFOLDS USED IN TISSUE ENGINEERING AND THEIR APPLICATIONS IN MEDICINE AND DENTISTRY." In Futuristic Trends in Medical Sciences Volume 3 Book 17. Iterative International Publisher, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bgms17ch16.

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Tissue engineering and regenerative medicine are promising trailblazing applications that necessitate the creation of biomaterials in order to create functional structures that replace, preserve, or enhance damaged tissues or whole organs. The primary focus in these fields is on developing biomaterials which replicate the physicochemical microenvironments of cells and tissues. By creating functioning replacements for damaged organs and tissues, like cartilage and osseous tissue, as well as cardiac and lung tissues, this branch of medicine has the potential to remarkably enhance the quality of
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Conference papers on the topic "Viability of organs as well as tissues"

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Hubel, A., N. Bidault, and B. Hammer. "Transport Characteristics of Glycerol and Propylene Glycol in an Engineered Dermal Replacement." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-32557.

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The ability to cryopreserve engineered tissues is important for the clinical application of therapies based on living cells. Cryopreservation facilitates the manufacture, transport and safety of cell-based therapies. The cryopreservation of cells and tissues had typically required the use of specialized solutions containing cryoprotective agents (CPAs). The addition of a CPA to the freezing solution may result in damage if it is not done properly. Tissues and intact organs can exhibit reduced cellular viability when exposed to sufficiently large step changes in external osmolarity resulting fr
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Quigley, Connor, Slesha Tuladhar, and Md Ahasan Habib. "A Bio-Printing Strategy to Fabricate Geometrically Accurate 3d Scaffolds." In ASME 2022 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/imece2022-95300.

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Abstract 3D bioprinting is a promising field in regenerating patient-specific tissues and organs due to its inherent capability of releasing biocompatible materials encapsulating living cells in a predefined location. Due to the diverse characteristics of tissues and organs in terms of microstructures and cell types, a multi-nozzle extrusion-based 3D bioprinting system has gained popularity. The investigations on interactions between various biomaterials and cell-to-material can provide relevant information about the scaffold geometry, cell viability, and proliferation. Natural hydrogels are f
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Seawright, Angela, and Bumsoo Han. "Effects of Freezing on Cytoskeletal Structure of Fibroblasts in Engineered Tissues." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53105.

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Successful preservation of functional cells and tissues are critical to cell/tissue engineering and regenerative medicines. One of the most reliable methods of cell/tissue preservation is cryopreservation; in which cells and tissues are frozen before storage and thawed when needed. Since the cellular viability and the microstructure of extracellular matrix (ECM) directly correspond to the functionality of a tissue, successful cryopreservation should maintain the extracellular matrix (ECM) microstructure as well as cellular viability post-thaw. A few recent studies [1,2] reported that complex c
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Yoshimori, Takashi, Masaki Fukagawa, and Hiroshi Takamatsu. "Effect of Cell-to-Surface Interaction on Freeze Tolerance and Osmotic Response of Cells." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192404.

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Cryopreservation of tissues and organs, including artificial organs, could be one of the important steps in the medical service that brings the progress in the tissue engineering to realization. In this case, high viability of cryopreserved cells is critical to recovery after transplantation. In contrast, in the cryosurgery, which is expected to expand its application as a minimally invasive treatment of cancer, malignant cells should be destructed completely to prevent from recurrence. The appropriate freeze-thaw protocol is therefore needed to be established for cryopreservation or cryosurge
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Zhang, Yahui, Howard Chen, and Ibrahim T. Ozbolat. "Characterization of Printable Micro-Fluidic Channels for Organ Printing." In ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-85622.

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Organ printing is a complex and challenging process in execution due to the lack of fundamental understanding of tissue and organ formation, and problems associated with giving the organ-conforming 3D shapes. One of the major challenges is the inclusion of blood vessel-like channels between layers to support cell viability in terms of nutrients and oxygen transport. Tissue scaffolds have been widely used in generation of replacement tissue by providing mechanical support and fluid nutrients, but complications with scaffold degradation and the corresponding adverse effects on extra cellular mat
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Choi, Jeunghwan, and John C. Bischof. "Attachment State Shifts Viability Versus Cooling Rate (Inverted U Curve) During Freezing for Human Dermal Fibroblasts." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53156.

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A large number of studies in cryobiology have focused on understanding the underlying biophysics at the cellular level to help predict survival outcome after cryopreservation or cryosurgery. While this behavior is increasingly well studied and understood in cells gaps remain in our understanding of how cells in tissues behave which can hamper freezing applications in tissues. This study compares freezing behavior in cells in suspension vs. attached (a model tissue) state to investigate any differences in cellular behavior in these two states.
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Nelson, Cartwright, Slesha Tuladhar, and MD Ahasan Habib. "Developing Hybrid Hydrogels for Full-Scale Scaffold Fabrication Using Extrusion-Based Bioprinting Process." In ASME 2022 17th International Manufacturing Science and Engineering Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/msec2022-85372.

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Abstract Three-dimensional (3D) bioprinting is a technology that has the power to positively change the medical and pharmaceutical fields in a new and more intuitive way. The goal of this rapidly growing field is to recreate functional tissues, but the process requires the ability to achieve large full-scale scaffolds that replicate human organs. There are many challenges when attempting to print large scaffolds ensuring proper internal and external geometric fidelity that is also suitable for the living cells that undergo the printing process. In order to fabricate a larger and more structura
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Yu, Yin, and Ibrahim T. Ozbolat. "Bioprinting Induced Cell Damage in Cellular Micro-Fluidic Channel Fabrication." In ASME 2013 International Manufacturing Science and Engineering Conference collocated with the 41st North American Manufacturing Research Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/msec2013-1081.

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Bioprinting, or layer by layer additive tissue fabrication, is a revolutionary concept recently emerged as an interdisciplinary effort to produce three-dimensional living organ for clinical application. Among many challenges, it was agreed that inclusion of vascular system is critical for maintaining the viability and functionality of relatively thick 3D bioprinted tissue constructs. Our previous research addressed the printability of novel vessel-like micro-fluidic channels with alginate hydrogel and co-axial nozzles. Here, we further investigated the influence of bioprinting parameters on ca
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Seawright, Angela, Altug Ozcelikkale, J. Craig Dutton, and Bumsoo Han. "Role of Cells in Freezing-Induced Cell-Fluid Matrix Interactions Within Engineered Tissues." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80531.

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Cryopreservation can provide long-term storage of various biological tissues, which has significant impact on tissue engineering and regenerative medicine. For successful cryopreservation of tissues, tissue functionality must be maintained including physical properties such as mechanical, optical, and transport properties, as well as cellular viability. Such properties are associated with the extracellular matrix (ECM) microstructure. Thus, the preservation of the ECM microstructure may lead to successful cryopreservation [1,2]. Yet, there is still very little known about changes in the ECM mi
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Rabin, Yoed, Justin S. G. Feig, Alexander C. Williams, Christopher C. Lin, and Chandrajit Thaokar. "Cryomacroscopy in 3D: A Device Prototype for the Study of Cryopreservation." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80527.

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This study presents a new device prototype for visualization of physical effects associated with large-scale cryopreservation—the preservation of tissues at very low temperatures. Cryopreservation represents the only method for long-term preservation of biomaterials. While techniques for cryopreservation of single cells and small tissue structures are well established, cryopreservation techniques for bulky tissues and organs are still at the developmental stage. Critical to the success of cryopreservation is the control of ice formation—the cornerstone of cryoinjury. One of the most promising
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Reports on the topic "Viability of organs as well as tissues"

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Kizilbash, Insia, Zonghu Han, Srivasupradha Ramesh, et al. Toxicity Measurements for Human-Scale Organ Vitrification CPAs. Journal of Young Investigators, 2025. https://doi.org/10.22186/jyi.28.6.1.1.

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Vitrification is a cryopreservation method that employs high concentrations of cryoprotective agents (CPA) to preserve organ viability indefinitely. Achieving vitrification typically requires CPA concentrations of 8–9M to effectively permeate tissues or organs; however, these levels are associated with significant toxicity. The CPA toxicity rate (k) quantifies the rate at which CPAs induce cytotoxic effects, influenced by CPA formulation, concentration and temperature. CPAs such as VM3 (8.46M), M22-PVP (9.34M) and M22 (9.35M) are currently under investigation for large organ cryopreservation.
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Ginzberg, Idit, Richard E. Veilleux, and James G. Tokuhisa. Identification and Allelic Variation of Genes Involved in the Potato Glycoalkaloid Biosynthetic Pathway. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593386.bard.

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Steroidal glycoalkaloids (SGAs) are secondary metabolites being part of the plant defense response. The two major SGAs in cultivated potato (Solanum tuberosum) are α-chaconine and α-solanine, which exhibit strong cellular lytic properties and inhibit acetylcholinesterase activity, and are poisonous at high concentrations for humans. As SGAs are not destroyed during cooking and frying commercial cultivars have been bred to contain low levels, and their content in tubers should not exceed 20 mg/100 g fresh weight. However, environmental factors can increase tuber SGA content above the safe level
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Sisler, Edward C., Raphael Goren, and Akiva Apelbaum. Controlling Ethylene Responses in Horticultural Crops at the Receptor Level. United States Department of Agriculture, 2001. http://dx.doi.org/10.32747/2001.7580668.bard.

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Ethylene is a plant hormone that controls many plant responses, such as growth, senescence, ripening, abscission and seed germination. Recently, 1-methy- cyclopropene (1-MCP), was shown to bind to ethylene receptor for a certain period of time and prevent ethylene action. The objectives of this research were to synthesize analogues of 1-MCP and test their potency to block the ethylene receptor and inhibit ethylene action. During the course of this project, procedures for synthesis and shipment of the cyclopropene compounds were developed as well assay procedures for each compound were worked o
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Bercovier, Herve, and Ronald P. Hedrick. Diagnostic, eco-epidemiology and control of KHV, a new viral pathogen of koi and common carp. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695593.bard.

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Original objectives and revisions-The proposed research included these original objectives: field validation of diagnostic tests (PCR), the development and evaluation of new sensitive tools (LC-PCR/TaqManPCR, antibody detection by ELISA) including their use to study the ecology and the epidemiology of KHV (virus distribution in the environment and native cyprinids) and the carrier status of fish exposed experimentally or naturally to KHV (sites of virus replication and potential persistence or latency). In the course of the study we completed the genome sequence of KHV and developed a DNA arra
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Lichter, Amnon, David Obenland, Nirit Bernstein, Jennifer Hashim, and Joseph Smilanick. The role of potassium in quality of grapes after harvest. United States Department of Agriculture, 2015. http://dx.doi.org/10.32747/2015.7597914.bard.

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Objectives: The objectives of the proposal were to study how potassium (K) enters the berry and in what tissues it accumulates, to determine what is the sensitive phenological stage that is responsive to K, to study the influence of K on sugar translocation, to determine if K has effects on expression of genes in source and sink organs and to study applied aspects of the responses to K at the vineyard level. During the research it was realized that K acts externally so a major part of the original objectives had to be deserted and new ones, i.e. the role of K in enhancing water loss from the b
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