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Dissertations / Theses on the topic 'Viral antigen'

Author: Grafiati

Published: 1 April 2023

Last updated: 31 July 2025

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1

Clayton, Anne-Louise. "Immunoassays for viral antigen detection in clinical specimens." Thesis, Open University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254677.

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2

Kučinskaitė-, Kodzė Indrė. "Production, Characterization And Application Of New Monoclonal Antibodies Against Viral Antigens." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2011. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2011~D_20110630_104940-67693.

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The dissertation describes development and characterization of monoclonal antibodies against recombinant yeast-expressed antigens: nucleocapsid (N) proteins of human parainfluenza virus type 3, Menangle virus, hantavirus and rabies virus. The newly developed antibodies were investigated by different immunochemical assays for their specificity, affinity and ability to recognize native viruses in infected cells. It was determined that the antibodies raised against recombinant yeast-expressed viral proteins are suitable to identify virusinfected cells. These data confirmed that recombinant yeast-

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3

Nastke, Maria-Dorothea. "T-cell epitopes from viral and tumor associated antigens induction and analysis of antigen-specific T cells /." [S.l. : s.n.], 2005. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB12168223.

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4

Chen, Yun-Chi. "Control of immune response and pathogenesis by antigen during viral infection." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413974.

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5

Glew, Elizabeth Jane. "The interaction of bovine viral diarrhoea virus with antigen presenting cells." Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312578.

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6

Biswas, Sumi. "Prime boost vaccination with viral vectors targeting apical membrane antigen 1." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:a17ab4e4-9b81-4ab3-b02f-41d9da36c6ab.

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Apical membrane antigen 1 (AMA1) is a leading candidate vaccine antigen against blood stage malaria and several clinical trials using mostly protein-in-adjuvant vaccines have shown limited success. This thesis describes the development of recombinant adenoviral (AdHu5) and poxviral (MVA) vectors encoding AMA1 from Plasmodium chabaudi murine parasites. In this murine malaria model, AdHu5 and MVA encoding AMA1 when used in a heterologous prime boost regime showed excellent immunogenicity, both humoral and cellular. The vaccination regime was protective against blood stage challenge and both anti

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7

Wong, Hiu-ling Beatrice. "Development of antibody and antigen detection assays and vaccines for SARS associated coronavirus." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B39634024.

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8

Wong, Hiu-ling Beatrice, and 黃曉靈. "Development of antibody and antigen detection assays and vaccines for SARS associated coronavirus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634024.

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9

Bhati, Anubhuti. "EXPRESSION OF HEPATITIS C VIRAL NON-STRUCTURAL 3 ANTIGEN IN TRANSGENIC CHLOROPLASTS." Master's thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3076.

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Hepatitis C viral infection is the major cause of acute hepatitis and chronic liver disease and remains the leading cause of liver transplants (NIH). An estimated 180 million people are infected globally (WHO). There is no vaccine available to prevent hepatitis C. The treatment with antiviral drugs is expensive, accompanied with various side effects and is limited only to those at risk of developing advanced liver disease. The treatment is also effective in only about 30% to 50% of treated patients and still a high percentage of patients are resistant to therapy. Therefore, there is an urgent

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10

Lee, Sang-Ryul. "Bovine viral diarrhea virus infections affect professional antigen presentation in bovine monocytes." Diss., Mississippi State : Mississippi State University, 2007. http://library.msstate.edu/etd/show.asp?etd=etd-10222007-092315.

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11

Rao, Ankit Rohit. "Engineering an improved dendritic cell vaccine expressing whole antigen following non-viral transfection." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3622/.

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Dendritic cells are efficient antigen-presenting-cells that can be used in tumour-antigen specific vaccination for malignant disease. Melanoma patients were recently treated with a dendritic cell vaccine expressing gp100 and Melan-A antigens after non-viral (CL22 peptide) transfection. Although clinical and immunological responses were noted, there was no correlation between responses and whole antigen expression levels in the vaccine cells that varied widely. Here, it is established that patient cells expressed detectable levels of Class I restricted epitopes from both antigens, although ther

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12

Umami, Rifqiyah Nur. "Effect of Viral and Host Factors on Hepatitis B Virus Surface Antigen Secretion." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29753.

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Hepatitis B virus (HBV) is the etiological cause of chronic hepatitis B (CHB), a leading cause of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Despite the availability of prophylactic vaccines, CHB remains incurable due to the persistence of covalently closed circular DNA (cccDNA) which continuously produces viral transcripts. Therefore, new strategies for CHB treatment are needed. One of these strategies is to reduce HBsAg, a hallmark of CHB. High levels of HBsAg inhibit the antiviral immune response. Thus, reduction of HBsAg levels in blood will ultimately allow recovery of

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13

Janbazian, Loury. "Effect of antigen load and viral sequence diversification on HIV-specific CD8+ T cells." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86806.

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Virus-specific CD8+ T cells have been implicated in the control of acute HIV and SIV infections. Although present in chronic HIV-1 infection, CD8+ T cells exhibit impaired functions due to unidentified molecular signatures. This has urged researchers to revisit parameters that define efficacious CD8+ T cell responses in HIV-1. To this date, polyfunctionality has emerged as the key feature of CD8+ T cell efficacy in chronic infection. Moreover, it is established that T-cell Receptor (TCR) diversity in HIV-specific CD8+ T cells plays a critical role in controlling viremia. Although TCR repertoir

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14

Liu, Mengya. "NanoAPC deliver antigen, IL-2 and co-stimulatory molecules to antigen specific T cells and activate viral specific T cells in chronic infections." Thesis, Brunel University, 2011. http://bura.brunel.ac.uk/handle/2438/6413.

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The study of the immune system has provided insight in the mechanism of protection induced by vaccination; primarily that most clinically protective vaccines are potent in generating neutralizing antibody responses. However, vaccination fails to protect against a wide range of acquired chronic infections caused by viruses, such as HIV, HBV and HCV. One of the major reasons for weak responses to therapeutic vaccine is the impaired function of effector T cells resulting from viral persistence. Although IL-2 can potently increase effect function of viral specific T cells, systemic administration

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15

Wang, Weiping. "SV40 large T antigen helicase roles of the hydrophilic channels and a newly identified unwinding activity /." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 152 p, 2009. http://proquest.umi.com/pqdweb?did=1833646471&sid=7&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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16

Peng, Yu-Cai. "Interactions between polyomavirus large T antigen and the viral replication origin DNA, how and why." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0028/NQ50235.pdf.

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17

Peng, Yu-Cai 1965. "Interactions between polyomavirus large T antigen and the viral replication origin DNA : how and why." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=35927.

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Polyomavirus large T antigen is the major regulatory protein in the polyomavirus life cycle. It binds to multiple G(A/G)GGC pentanucleotide sequences in sites 1/2, A, B, and C within and adjacent to the origin of viral DNA replication on the polyomavirus genome. The nature of interactions between large T antigen and the viral origin of DNA replication is not fully understood. We set out to produce large T antigen protein in the methylotropic yeast Pichia pastoris by placing the large T antigen gene downstream of the strong alcohol oxidase (AOX1) promoter. Large T antigen was purified by immuno

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18

Dubosq, Ming-Celine. "The non-viral production of Chimeric Antigen Receptor T-cells for B-cell haematological malignancies." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23170.

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Chimeric antigen receptor (CAR) T-cells are genetically engineered to express a synthetic receptor which redirects their specificity and effector functions to a tumour associated antigen. They have induced unsurpassed clinical responses in patients with relapsed and refractory CD19-positive haematological malignancies who hitherto had limited treatment options. Currently, all commercially available CAR T-cell products are manufactured using viral vectors for transduction, an efficient but highly costly and complex process. Thus, access to CAR T-cell therapy is inequitable. Historically, the

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19

張紀忠 and Jizhong Zhang. "Conformational antigenic determinants of the HEV CAPSID." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31241360.

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20

Zhang, Jizhong. "Conformational antigenic determinants of the HEV CAPSID /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2207918X.

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21

McMurtrey, Curtis Paul. "Human leukocyte antigen class I presentation and immune recognition of West Nile virus peptide epitopes." Oklahoma City : [s.n.], 2009.

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22

Rodríguez, Plata Mª Teresa. "Dendritic Cells and HIV-1: Molecular Mechanisms Involved in Viral Capture, Trans-infection and Antigen Presentation." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/120537.

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Les cèl·lules dendrítiques (CD) són les cèl·lules presentadores d’antigen més potents del sistema immuntari, enllaçant la immunitat innata i la immunitat adquirida. No obstant això, les CD poden contribuir a la disseminació del Virus de la Immuno-deficiència Humana tipus 1 (VIH-1) mentre intenten induir una resposta adaptativa contra la infecció viral. El paradigma immunològic clàssic sobre la funció de les CD indica que les CD immadures principalment capturen patògens, mentre que les CD madures indueixen una resposta adaptativa contra el patogen capturat. Però, la maduració de les CD amb lipo

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23

McLean, Brendan Norbert. "The detection of viral antigen in the cerebrospinal fluid of patients with herpes simplex virus encephalitis." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/26759.

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A highly sensitive capture sandwich antibody assay was developed for the detection of Herpes Simplex Virus alkaline nuclease in cerebrospinal fluid. Chemiluminescence, using Isoluminol labelled antibody and p-Iodophenol enhanced Horse-Radish Peroxidase catalysed Luminol, was compared with Horse-Radish Peroxidase colorimetric detection in the assay. Luminol was superior to Isoluminol based chemiluminescence, but this was no more sensitive than colorimetric detection. In vitro the final optimised colorimetric assay had a sensitivity of 20 plaque forming units of Herpes Simplex Virus. A method fo

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24

Mahauad, Fernandez Wadie Daniel. "Role of bone marrow stromal antigen 2 (BST-2) in viral pathogenesis and breast cancer progression." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/6191.

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Bone marrow stromal antigen 2 (BST-2/tetherin) is a type II transmembrane protein that plays various roles, including protective and detrimental roles in the host. Cellular responses to BST-2 expression or the lack thereof, may be cell type and context-dependent and may vary with time. When protective, BST-2 functions as an antiviral factor, renowned for its ability to tether budding enveloped viruses to the membrane of infected cells. Tethering of budding virions prevents their release into the extracellular milieu limiting infection of naïve cells. The antiviral role of BST-2 has been predom

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25

Nastke, Maria-Dorothea [Verfasser], and Hans-Georg [Akademischer Betreuer] Rammensee. "T-cell epitopes from viral and tumor associated antigens : induction and analysis of antigen-specific T cells / Maria-Dorothea Nastke ; Betreuer: Hans-Georg Rammensee." Tübingen : Universitätsbibliothek Tübingen, 2005. http://d-nb.info/1162199148/34.

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26

Meei-Yun, Lin. "Evolution of the T Cell Receptor Repertoire during and after Viral Infection: a Dissertation." eScholarship@UMMS, 1999. https://escholarship.umassmed.edu/gsbs_diss/244.

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The overall goal of this thesis is to examine how the T cell receptor (TCR) repertoire evolves during and after viral infections. Previous studies had examined TCR usage of selected virus-specific T cell clones, but little was known about how a diverse T cell repertoire changes during the transition between an acute infection and a memory response. It was also unclear how the T cell repertoire evolves under conditions of persistent infections associated with clonal exhaustion. To address these issues I used as a model system the lymphocytic choriomeningitis virus (LCMV) infection of

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27

Cho, Uhn-Soo. "Structural studies of protein phosphatase 2A, simian virus 40 small t antigen, and the PhoQ sensor domain /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5677.

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28

Wang, Xiaoting Z. "Organ-Dependent and Epitope-Dependent Repertoire Usage and Apoptosis of Antigen-Specific T Cells in Viral Infections: a Dissertation." eScholarship@UMMS, 2004. http://escholarship.umassmed.edu/gsbs_diss/285.

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During virus infections, activation of CD8 T cells takes place in secondary lymphoid organs including spleen and lymph nodes. The kinetics of the T cell response in lymphoid tissues has been clearly studied. However, a large number of virus-specific T cells disseminate into various nonlymphoid tissues. As reservoirs for effector and memory cells, nonlymphoid organs play an important role for defending against infections. T cell responses in nonlymphoid organs may differ from lymphoid organs. T cell repertoire usage in lymphoid and nonlymphoid tissues was studied in an acute lymphocytic choriom

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29

Novak, Erik Joseph. "Tracking antigen-specific immune responses in human infection and disease /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5084.

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30

Zarozinski, Christopher C. "T Cell Receptor-Dependent and Independent Events During Potent Anti-Viral T Cell Responses." eScholarship@UMMS, 1998. http://escholarship.umassmed.edu/gsbs_diss/175.

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The relative contribution of T cell receptor-dependent stimulation versus TcR-independent bystander stimulation in the massive increase in the number of activated proliferating CD8+ T cells seen during acute many acute viral infections is unclear. To determine if this increase was the result of TcR-independent bystander activation and proliferation, anti-viral cytotoxic T lymphocytes were induced in vivo via DNA immunization so that the anti-viral immune response could be examined in the absence of the high levels of cytokines generated during acute infection. After a single immunization with

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31

Carlsson, Björn. "Adoptive T Cell Therapy of Viral Infection and Cancer : Ex vivo Expansion of Cytomegalovirus- and Prostate Antigen-specific T Cells." Doctoral thesis, Uppsala University, Clinical Immunology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4821.

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<p>The main focus of my thesis has been to develop protocols for generating antigen-specific cytotoxic T lymphocytes (CTLs) and T helper cells (T<sub>H</sub>) for adoptive transfer to treat cytomegalovirus (CMV) disease and prostate cancer. CMV viremia is a severe complication in immunocompromised stem cell transplanted patients. Prostate cancer is a leading cause of death for men in Western countries. Although different in nature, CMV-infected cells and prostate cancer cells can both be eliminated through specific activation of the adaptive immune system. </p><p>To generate CMV pp65-specific

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32

Abeywickrama, Samarakoon Natali. "Small hepatitis Delta antigen mimics a histone H3 epitope to facilitate the remodeling of the Hepatitis D virus (HDV) viral ribonucleoprotein." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1193.

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Le virus de l'hépatite Delta (HDV) est un agent infectieux transmissible satellite du virus de l'hépatite B (HBV), induisant des maladies du foie plus sévères que la mono–infection par le HBV. Aucun traitement totalement efficace n'est disponible contre l'HDV et les 15 millions de personnes infectées par le HDV dans le monde sont exposées a un risque élevé de cirrhose et de carcinome hépatocellulaire. HDV est un virus unique qui ne code pas pour une polymérase virale contrairement aux autres virus a ARN. La réplication de l'ARN HDV s'effectue par un double mécanisme de cercle roulant générant

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33

Catamo, Eulalia. "Genetic variation in hla-g: its influence in autoinflammatory autoimmune and viral diseases." Doctoral thesis, Università degli studi di Trieste, 2014. http://hdl.handle.net/10077/9982.

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2012/2013<br>L'antigene leucocitario umano (HLA)-G presenta, in condizioni fisiologiche, una ristretta espressione tessuto-specifica ed ha funzione immuno-tollerogenica. Però, la presenza della molecola HLA-G è stata associata a diverse patologie autoimmuni e virali. In questo progetto di dottorato di ricerca abbiamo analizzato la possibile associazione tra la varianti genetiche nel gene HLA-G, che si suppone regolino l'espressione di HLA-G, e la suscettibilità allo sviluppo e al decorso della malattia celiaca, del lupus eritematoso sistemico, dell'artrite reumatoide e dell'infezione dal vir

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34

Moetlhoa, Boitumelo. "The preparation of antigen for the generation of polyclonal antibodies against the capsid subunit, VP1, and the viral protease, 3Cpro, of Theiler's murine encephalomyelitis virus (TMEV)." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1013225.

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The Picornaviridae is a family of viruses of economic importance that have a major impact on human and animal health. Some of the major genera found in the Picornaviridae family are Enterovirus which includes Poliovirus (PV) and Human Rhinovirus (HRV), Cardiovirus which includes Theiler’s murine encephalomyelitis virus (TMEV) and Saffold virus (SAFV), Aphthovirus of which the Foot and Mouth disease virus (FMDV) is a member and Hepatovirus which includes Hepatitis A virus (HAV). Picornaviruses have a single stranded, positive sense RNA genome which is approximately 7.5-8.4 kb pairs in size. The

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35

Almqvist, Jenny. "Epstein-Barr virus nuclear antigen 1, Oct & Groucho/TLE in control of promoter regulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-523-2/.

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36

Warnatsch, Annika. "Impact of proteasomal immune adaptation on the early immune response to viral infection." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16775.

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Im Kampf gegen eine Virusinfektion spielen CD8+ T Zellen des adaptiven Immunsystems eine besondere Rolle. Sie patroullieren im Körper und entdecken spezifische Virusepitope, welche mittels MHC Klasse I Molekülen auf der Oberfläche infizierter Zellen präsentiert werden. Wird eine virus-infizierte Zelle erkannt, kann diese schnell und effizient eliminiert. Für die Generierung viraler Peptide, welche auf MHC Klasse I Komplexe geladen werden, ist das Ubiquitin-Proteasom-System von essentieller Bedeutung. Kürzlich wurden weitere Funktionen des Immunoproteasoms aufgedeckt wie zum Beispiel der Schutz

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37

Söderholm, Jonas. "The hepatitis C virus and immune escape : relation between sequence variations and the in vitro and in vivo functionality of the non-structural 3/4A complex /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7357-042-7/.

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38

RIZZO, SERENA. "IDENTIFICATION AND PRODUCTION OF RECOMBINANT ANTIBODIES TARGETING WEST NILE VIRUS THROUGH NAÏVE AND IMMUNIZED PHAGE-DISPLAY LIBRARIES." Doctoral thesis, Università degli Studi di Trieste, 2019. http://hdl.handle.net/11368/2991028.

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West Nile virus (WNV) is a member of the Flavivirus genus, which includes several human pathogens transmitted by arthropod vectors. The maintenance in nature of WNV is possible through a bird-mosquito life cycle, in which mosquitoes act as transmission vectors and birds as virus amplification hosts. Humans are not able to contribute to WNV transmission cycle, therefore are defined accidental or dead end hosts. The 20% of WNV infected patients develop a mild disease with influenza like symptoms known as West Nile fever, while in the 1% of cases the viral infection results in a severe neuroinva

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39

Trujillo, Jonathan Anthony. "T cell responses to S-glutathionylated And heteroclitic viral epitopes and CCl2-mediated immune dysregulation in mice infected with a neurotropic coronavirus." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/4775.

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Mice infected with neurotropic variants of the murine coronavirus, mouse hepatitis virus, (strains JHMV or J2.2–V–1) develop acute and chronic CNS infections, and provide a model system to study the pathogenesis of virus–induced neuroinflammation, mechanisms of virus persistence, and anti–viral immune responses in the CNS. Using the J2.2–V–1 model of CNS infection, we addressed the role of sustained CCL2 production during viral infection using mice in which CCL2 was expressed transgenically in oligodendrocytes. Tonic CCL2 expression in the CNS resulted in delayed kinetics of virus clearance, a

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40

Monjezi, Razieh [Verfasser], and Michael [Gutachter] Hudecek. "Engineering of chimeric antigen receptor T cells with enhanced therapeutic index in cancer immunotherapy using non-viral gene transfer and genome editing / Razieh Monjezi ; Gutachter: Michael Hudecek." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1162062231/34.

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Lazaro, Estibaliz. "Impact du sous-type viral et de l’apprêtement antigénique sur la présentation des épitopes du VIH-1 par les molécules HLA de classe I." Thesis, Bordeaux 2, 2010. http://www.theses.fr/2010BOR21776/document.

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Les lymphocytes T cytotoxiques (CTLs) dirigés contre le VIH jouent un rôle essentiel dans la défense anti-virale. L’identification des facteurs impliqués dans la variabilité de ces réponses est indispensable à la mise au point de vaccins efficaces.Nous avons focalisé notre travail sur deux facteurs potentiellement impliqués dans la reconnaissance du virus par le HLA : le sous-type viral et la qualité de l’apprêtement antigénique. L’extrême variabilité du virus avec à ce jour 11 sous-types et 48 formes recombinantes (CRFs) circulant au sein de populations au typage HLA hétérogène implique un po

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42

Xu, Dan. "Cellular Immunity in Recombinant Adeno-Associated Virus Vector Mediated Gene Therapy." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313504203.

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43

Chernyukh, O. G. "Qualitative detection of Ig G antibodies to SARS-CoV-2 coronavirus nucleocapsid antigen in the blood serum of patients who had viral respiratory infection, caused by SARS-CoV-2." Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19534.

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44

Mukherjee, Siddhartha. "The processing and presentation of viral antigens." Thesis, University of Oxford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390538.

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45

Lafon, Monique. "La nucleocapside du virus rabique : une nouvelle cible pour la reponse immunitaire et pour la therapie." Paris 7, 1987. http://www.theses.fr/1987PA077219.

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46

McMahon, Christopher Wolcott. "Structure-function analysis of mouse mammary tumor virus superantigens /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/8342.

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47

Jowett, Jeremy Bryan Mark. "Properties of recombinant HIV and SIV antigens." Thesis, University of Oxford, 1992. http://ora.ox.ac.uk/objects/uuid:5de3119b-4aa1-469a-80b6-f1f28dff4f5c.

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When expressed in Spodoptera frugiperda cells using recombinant baculoviruses, the HIV - 1 gag gene product, p55, self assembles to form immature HIV core like particles that are secreted into the culture medium. Using this system, the gag open reading frame was progressively truncated from the carboxy terminus, and each deleted Gag protein examined for its ability to produce core like particles. Deletions that removed the distal region of the Gag nucleocapsid domain, including both Cys - His motifs thought to function as RNA capture signals, did not disrupt particle formation. Analysis of the

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48

Perry, Sara Jane St John. "Novel delivery systems for SIV antigens." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321085.

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49

MAZZOLENI, ELISA. "Exploration of new techniques for purification and chemo-selective conjugation of bioreagents for immunodiagnostic applications." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2015. http://hdl.handle.net/10281/68468.

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Antigene e anticorpo sono i due reagenti chiave di un saggio immunodiagnostico. L’indagine di nuove tecniche e il miglioramento di processi quali la purificazione e la marcatura sito-specifica di antigeni e anticorpi possono promuovere lo sviluppo di nuovi reagenti più efficienti capaci di migliorare la performance dei saggi immunodiagnostici. La prima parte di questa tesi è stata focalizzata sull’esplorazione di tecniche biotecnologiche innovative nella produzione di antigeni al fine di migliorare i saggi per la rilevazione degli anticorpi IgM e IgG specifici per il virus Epstein-Barr. Il vi

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Stevenson, Philip G. "The immune response to viral antigens in the mouse brain." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364023.

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