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Dissertations / Theses on the topic 'Viral Encephalitis And Viral Meningitis'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Nunes, Cristina Freitas. "Etiologia das encefalites e meningites de líquor claro." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/99/99131/tde-27112018-144215/.

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Infecções no sistema nervoso central (SNC) causadas por microrganismos desencadeiam sintomas de moderados a severos, dependendo da região atingida, podendo ser designadas como encefalites ou meningites. Os vírus são os agentes mais comuns nestas infecções. Os agentes virais responsáveis por essas enfermidades que apresentam maior incidência na população mundial são certos herpesvírus, flavivírus, influenza A, enterovírus e vírus da caxumba. Entretanto, essa prevalência varia de acordo com a população, estado imunológico do indivíduo, idade e região estudada. Embora existam dados bem estabeleci

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2

Michael, Benedict. "Detection and diagnosis of acute viral encephalitis." Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2003409/.

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Introduction Acute viral encephalitis is a severe form of brain inflammation due to sporadic infection, typically with herpes simplex virus, or epidemic/pandemic infections. Epidemiological data are particularly important for pandemic viruses. Although new reporting approaches are often considered, no real-time clinical data collection tool has been developed. These data are dependent on diagnosis of individual cases. However, the aspects of management that result in delays and missed diagnoses are not clear and it is not known if interventions can improve sample collection and diagnosis. Whil

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3

Raza, Muhammad Waqar. "Viral infections as predisposing factors for bacterial meningitis." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/20135.

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Epidemiological data suggest that viral infections might be predisposing factors for bacterial meningitis and carriage of type b <i>Haemophilus influenzae</i> (Hib), <i>Neisseria meningitidis</i> or <i>Streptococcus pneumoniae</i>, the three pathogens most commonly associated with bacterial meningitis. Non-secretors of ABO blood group antigens are over-represented among patients with bacterial meningitis and in populations affected by some outbreaks. The first objective of the study was to examine the hypothesis that non-secretors were also over-represented among patients with respiratory vira

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4

Pajek, Daniela. "Identifying chemokine receptors as plausible therapeutic targets in viral encephalitis." Thesis, University of Glasgow, 2013. http://theses.gla.ac.uk/4764/.

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Background: There are a large number of viruses spread by mosquitoes, many of which cause debilitating, often fatal, neurological disease such as acute encephalitis. In this study we have used two different neurotropic viruses: Semliki Forest virus (SFV), and West Nile virus (WNV), both of which can cause severe panencephalitis in the mouse. The influx of leukocytes into the infected tissues is mediated by chemokines and is believed to be important for virus clearance. To date, we have only limited insights into the precise nature of chemokine involvement, and an improved understanding of thes

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5

Alshaikh, Sana. "A novel and sensitive molecular method for nucleic acid discovery in CSF samples." Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/a-novel-and-sensitive-molecular-method-for-nucleic-acid-discovery-in-csf-samples(65c2353b-40c2-4856-8af6-c64d86773e3e).html.

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Encephalitis is a matter for serious public health concern because of the high morbidity and mortality associated with many cases. Epidemiological studies have shown that viral encephalitis (VE) is more common than the sum of encephalitis caused by all other pathogens. However, more than 95% of cases have no known cause. Thus, there is a significant need to develop a sensitive method for the diagnosis of these unknown cases. Previous sequence independent amplification (SIA) assays have proved successful in detecting new viruses in many biological samples but not in CSF samples. This may be due

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6

Cox, Darren Anthony. "Modulation of Murine Haematopoietic Responses During Viral Encephalitis and Other Inflammatory Diseases." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21381.

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During homeostatic conditions replenishment of the hematopoietic system occurs through the constitutive release of differentiated cells from the bone marrow to the circulatory system. Depletion of these mature immune cells during an immune response results in a compensatory haematopoietic response that can involve suppression or amplification of haematopoiesis as well as phenotypical and functional variation of progenitor cells. However, in many cases lymphopoiesis is often suppressed and is usually concomitant with amplification of myelo and granulopoiesis in a process known as “emergency gr

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7

Goldhardt, Joseph L. "Role of the Japanese Encephalitis Virus Envelope Glycoprotein E in Viral Pathogenicity." DigitalCommons@USU, 2019. https://digitalcommons.usu.edu/etd/7707.

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Japanese encephalitis virus (JEV) is the causative agent of Japanese encephalitis (JE), the leading cause of vaccine-preventable neurological disease. JEV is a flavivirus that is primarily transmitted through the bite of infected mosquitoes, similar to dengue virus (DENV), St. Louis encephalitis virus (SLEV), West Nile virus (WNV), and Zika virus (ZIKV). The two viral characteristics that dictate virulence are (1) neuroinvasiveness, the ability of the virus to invade the central nervous system(CNS), and (2) neurovirulence, the capacity of the virus to kill resident cells in the CNS. The clinic

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8

Bush, Victoria Louise. "The interaction of Neisseria meningitidis with host cells." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361473.

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9

Golovljova, Irina. "Viral zoonoses in Estonia : hantaviruses and tick-borne encephalitis virus : identification, prevalence, serological and genetic relationships /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-664-6/.

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10

Ashhurst, Thomas Myles. "Mobilisation of the murine haematopoietic system in the bone marrow during viral encephalitis." Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21393.

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Viral infection of the central nervous system (CNS) with West Nile virus (WNV) or Zika virus (ZIKV) results in a rapid influx of monocyte-derived macrophages, that ultimately induce fatal pathology in the mouse. Whilst these cells are suspected to originate from the bone marrow (BM), little is known about the kinetic and migratory events that might mobilise BM monocytes and their progenitors in response to CNS infection. In this study we conducted comprehensive mapping of the murine central nervous system (CNS) and haematopoietic system in the BM using high-dimensional 29-parameter flow cytome

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11

Trócoli, Maria Graziela Cavalcanti. "Epidemiologia das meningites bacterianas e virais agudas ocorridas no Instituto Estadual de infectologia Säo Sebastiäo (IEISS) - Rio de Janeiro - Período 11.11.96 a 10.06.97." reponame:Repositório Institucional da FIOCRUZ, 1998. https://www.arca.fiocruz.br/handle/icict/4650.

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Made available in DSpace on 2012-09-06T01:11:04Z (GMT). No. of bitstreams: 2 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 99.pdf: 2691977 bytes, checksum: 3fa2eff2b005ba0c1d8204b7a0ffaf2c (MD5) Previous issue date: 1998<br>Descreve um estudo de Coorte Descritivo Retrospectivo, realizado com dados obtidos através de prontuários de pacientes internados no Instituto Estadual de Infectologia Säo Sebastiäo, no período de 11/96 a 06/97, que tiveram diagnóstico definitivo de meningite bacteriana ou viral. Procedeu-se às estimativas das gravidade e letalidade, de amba

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Oliveira, Bruna Rezende Silva Martins de. "Expressão gênica de mediadores associados a neuropatogênse causada pelo BHV5 /." Araçatuba, 2018. http://hdl.handle.net/11449/154957.

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Orientador: Tereza Cristina Cardoso Silva<br>Banca: Roberto Gameiro de Carvalho<br>Banca: Andréa Fontes Garcia<br>Banca: Ana Carolina Borsanelli<br>Banca: Jamila Cristina Baptistella<br>Resumo: O herpes vírus bovino 5 (HVB-5) é um agente infeccioso pertencente a família Herpesviridae, sub-família Alphaherpesvirinae e gênero Varicellovirus. É um vírus neurotrópico que causa doenças neurológicas principalmente em animais jovens em todo mundo, especialmente nos países Sul-americanos, resultado em significantes perdas econômicas. A infecção pelo herpesvírus bovino 5 em gado jovemestá associado a d

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13

Коленко, Фаіна Григорівна, Фаина Григорьевна Коленко, Faina Hryhorivna Kolenko, Т. Л. Головашова та І. М. Головашова. "Лікування наслідків перенесеного вірусного енцефаліту - лицьового геміспазму". Thesis, Видавництво СумДУ, 2008. http://essuir.sumdu.edu.ua/handle/123456789/3699.

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14

Al-Sulaiman, Abdulrahman. "Serological array for the diagnosis of viral infection of the central nervous system." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/serological-array-for-the-diagnosis-of-viral-infection-of-the-central-nervous-system(5c23bcf7-0679-437a-9617-342fc53e96d7).html.

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Encephalitis caused by the alphaherpes viruses HSV 1, HSV 2 and VZV can be devastating and rapid, accurate diagnosis is required. Whilst existing molecular techniques are invaluable in diagnosing acute disease, detection of antibody is needed to confirm infection and to make a diagnosis after the acute stage or during post-infectious encephalitis. Current immunoassays are limited by the volume of sample required. The aim of this project was to develop a rapid, accurate, low sample volume assay to improve diagnosis using Luminex technology.The immunodominant proteins of HSV and VZV, glycoprotei

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15

Aronsson, Fredrik. "Neurotropic influenza A virus infection in the mouse brain : targeting, persistence and functional effects /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-662-6/.

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16

McLean, Brendan Norbert. "The detection of viral antigen in the cerebrospinal fluid of patients with herpes simplex virus encephalitis." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/26759.

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A highly sensitive capture sandwich antibody assay was developed for the detection of Herpes Simplex Virus alkaline nuclease in cerebrospinal fluid. Chemiluminescence, using Isoluminol labelled antibody and p-Iodophenol enhanced Horse-Radish Peroxidase catalysed Luminol, was compared with Horse-Radish Peroxidase colorimetric detection in the assay. Luminol was superior to Isoluminol based chemiluminescence, but this was no more sensitive than colorimetric detection. In vitro the final optimised colorimetric assay had a sensitivity of 20 plaque forming units of Herpes Simplex Virus. A method fo

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17

Passoni, Gabriella. "Unraveling viral encephalitis in vivo : dynamic imaging of neuro-invasion and neuro inflammation processes in the zebrafish." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066644/document.

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Le danio zébré est un modèle bien établi pour étudier la biologie du développement des vertébrés. Ses larves transparentes sont favorables à des approches de microscopie non invasive, qui permettent de réaliser des observations à l’échelle d’un individu entier à des niveaux de résolution cellulaire et subcellulaire. Ces atouts font du danio zébré un excellent modèle pour étudier les infections virales in vivo. Au cours de mon projet, j’ai etudié l’entrée et la colonisation du système nerveux central (SNC) par le virus Sindbis (SINV) dans le modèle danio zébré. Mon projet présentait p

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Passoni, Gabriella. "Unraveling viral encephalitis in vivo : dynamic imaging of neuro-invasion and neuro inflammation processes in the zebrafish." Electronic Thesis or Diss., Paris 6, 2015. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2015PA066644.pdf.

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Le danio zébré est un modèle bien établi pour étudier la biologie du développement des vertébrés. Ses larves transparentes sont favorables à des approches de microscopie non invasive, qui permettent de réaliser des observations à l’échelle d’un individu entier à des niveaux de résolution cellulaire et subcellulaire. Ces atouts font du danio zébré un excellent modèle pour étudier les infections virales in vivo. Au cours de mon projet, j’ai etudié l’entrée et la colonisation du système nerveux central (SNC) par le virus Sindbis (SINV) dans le modèle danio zébré. Mon projet présentait p

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19

Caligiuri, Kyle. "Investigation of the deregulated miRNome identified during acute viral infections in a murine model of HSV-1 encephalitis." Springer Science+Business Media, LLC, 2013. http://hdl.handle.net/1993/23926.

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Herpes simplex virus type 1 (HSV-1) is a double stranded DNA virus that causes epithelial skin infections and persists through the life of the host by infecting neurons, where it can switch to a latent state to evade an immune response. In rare cases during primary infection or after reactivation, instead of undergoing lytic infection at the epithelial surface, it instead travels to the brain and causes herpes simplex virus encephalitis (HSVE) which can have a ≥70% mortality rate if untreated. As the virus takes over its host cell, it gains control of the host cell machinery and manipulates

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20

Rosario, Wenzel Ileana del. "Anatomical localization and kinetics of expression of HSV and MHC antigens during viral encephalitis in a mouse model /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487842372895558.

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21

Torres, Vitor Félix. "Receptor desencadeador expresso nas células mielóides Tipo 1 (TREM-1) no diagnóstico e prognóstico na meningite bacteriana em crianças." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/129631.

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Base teórica: A meningite bacteriana é uma causa importante de morbidade e mortalidade na infância. Análise do líquido cefalorraquidiano (LCR) continua a ser a ferramenta de diagnóstico padrão ouro, porém novos biomarcadores para o diagnóstico e prognóstico ainda são necessários. Receptor Desencadeador Expresso nas Células Mielóides Tipo 1 (TREM-1) é um receptor transmembrana expresso em neutrófilos e monócitos, que desempenha um papel importante na modulação da resposta inflamatória. A sua fração solúvel (sTREM-1) também é aumentada na infecção, inflamação ou doenças imunológicas. Neste estud

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22

Kindberg, Elin. "Host genetic risk factors to viral diseases - a double-edged sword : Studies of norovirus and tick-borne encephalitis virus." Doctoral thesis, Linköpings universitet, Molekylär virologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-54923.

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It is today well known that the outcome of a certain infection depends on factors of both the host and the pathogen. Studies of host genetic susceptibility to infectious diseases aim to increase the understanding of why some individuals are more susceptible than others, to a certain infection. Knowledge of genetic susceptibility to a viral disease may be used in development of new therapeutic means, and also to recognize individuals who are at increased risk of severe symptoms if infected with a pathogen. It seems however that a risk factor for one disease may play a protective role in another

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Pedraza-Ordóñez, Francisco Javier [UNESP]. "Resposta celular no encéfalo de coelhos experimentalmente inoculados com herpesvírus bovino 5 (BoHV-5)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/104612.

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Made available in DSpace on 2014-06-11T19:33:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-01-30Bitstream added on 2014-06-13T19:44:12Z : No. of bitstreams: 1 pedrazaordonez_fj_dr_jabo.pdf: 707975 bytes, checksum: 9868dbb427049fb448644457810a5e65 (MD5)<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>O BoHV-5 é um alfa herpesvírus neurovirulento, que causa meningoencefalite fatal em bezerros. A morbidade é baixa contrastando com uma alta mortalidade, embora alguns animais possam-se recuperar. Varias pesquisas tem sido desenvolvidas para determinar a pato

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Trandem, Kathryn Rydze. "The anti-inflammatory response in mice with coronavirus-induced encephalomyelitis." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3002.

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Infections in the central nervous system pose a considerable challenge to the host. On one hand, a quick and rapid immune response is important to control the infection, while on the other hand, too robust a response can damage the CNS, which has poor regenerative properties. Therefore, nowhere else in the body is such a balance between pro- and anti-inflammatory mediators as important. Mice infected with the coronavirus, mouse hepatitis virus strain J2.2-V-1, are a useful model for understanding the two sides of the immune system. In

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Vasconcelos, Rosemeri de Oliveira [UNESP]. "Participação da glia nas alterações morfológicas do cérebro e na produção de beta-quimiocinas na encefalite experimental pelo vírus da estomatite vesicular em camundongos." Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/104671.

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Made available in DSpace on 2014-06-11T19:33:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2003-02-18Bitstream added on 2014-06-13T19:44:14Z : No. of bitstreams: 1 vasconcelos_ro_dr_jabo.pdf: 1349333 bytes, checksum: 7eaa9b531ee75109ac659bcca081d17c (MD5)<br>A compreensão do comportamento da microglia frente a uma injúria viral contribui para o entendimento da dimensão da rede de comunicação celular, durante um processo degenerativo ou inflamatório no SNC. Pesquisas que utilizam modelos experimentais com o vírus da estomatite vesicular (VEV) têm colaborado com informações importantes

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Silva, Danilo Rezende e. "Detecção molecular de herpesvírus bovino tipo-1 e herpesvírus bovino tipo-5 em amostras de encéfalos bovinos incluídos em parafina." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/5337.

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Submitted by Cássia Santos (cassia.bcufg@gmail.com) on 2016-03-15T12:49:24Z No. of bitstreams: 2 Dissertação - Danilo Rezende e Silva - 2014.pdf: 795804 bytes, checksum: 70571f234568a148006646c85383db05 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-03-16T11:26:10Z (GMT) No. of bitstreams: 2 Dissertação - Danilo Rezende e Silva - 2014.pdf: 795804 bytes, checksum: 70571f234568a148006646c85383db05 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5

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Lauer, Katharina. "A multipathogen vaccine for rabies, hepatitis B, Japanese encephalitis and enterovirus 71." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/a-multipathogen-vaccine-for-rabies-hepatitis-b-japanese-encephalitis-and-enterovirus-71(f489f961-317e-4430-becc-0474cae79268).html.

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To enhance the global control of encephalitis and hepatitis caused by rabies virus (RABV), Japanese encephalitis virus (JEV), enterovirus 71 (EV71) and hepatitis B virus (HBV), novel immunisation strategies are needed. All four diseases particularly affect low income countries with marginal health services – an affordable combined vaccine strategy could alleviate the large burden of disease. Therefore, we aimed to construct a multipathogen vaccine assessing the immunising activity of a recombinant modified vaccinia Ankara (MVA), expressing key antigens (RABV-glycoprotein, JEV pre-membrane & en

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Pedraza-Ordóñez, Francisco Javier. "Resposta celular no encéfalo de coelhos experimentalmente inoculados com herpesvírus bovino 5 (BoHV-5) /." Jaboticabal : [s.n.], 2012. http://hdl.handle.net/11449/104612.

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Orientador: Antonio Carlos Alessi<br>Coorientador: Noeme Sousa Rocha<br>Banca: Gisele Fabrino Machado<br>Banca: Mary Suzan Varaschin<br>Banca: Rosemeri de Oliveira Vasconcelos<br>Banca: Luiz Carlos Marques<br>Resumo: O BoHV-5 é um alfa herpesvírus neurovirulento, que causa meningoencefalite fatal em bezerros. A morbidade é baixa contrastando com uma alta mortalidade, embora alguns animais possam-se recuperar. Varias pesquisas tem sido desenvolvidas para determinar a patogênese deste tipo de doença. No presente trabalho coelhos experimentalmente infectados com o Herpesvírus Bovino 5 (BoHV-5) fo

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Dyachenko, P. A., and A. G. Dyachenko. "Epidemiological analysis of herpesviral lesions of the nervous system." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64796.

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Primary herpesvirus infection usually occurs during childhood and may cause several benign self-limited clinical manifestations, followed by a life-long persistence in a latent state with possible reactivation in case of immunodeficiency. Serious health problems, including CNS lesions can occur as a result of HVs reactivation. Herpesvirus encephalitis (HVE) accounts for up to 40% of all viral encephalitis, and are major causes of mortality and long-term neurological sequelae throughout the world even when using antiviral drugs. Since surveillance and recording of herpesvirus infections (HVI) a

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Santos, Daniela Carvalho dos. "Estabelecimento de métodos moleculares para aplicação no diagnóstico rápido de virus neurotrópicos." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42132/tde-02122009-110053/.

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Diversos agentes virais são causadores de meningites e meningoencefalites. Neste estudo, técnicas moleculares foram utilizadas para detecção de HEV, HHV e HAdV em amostras de líquor colhidas de janeiro de 2005 a março de 2007. Dos três métodos de extração de DNA e RNA testados, o kit DNA Qiablood Qiagen® se mostrou o mais sensível e específico. A nested PCR detectou HEV em 28% das amostras, HSV em 4%, HHV-3 em 1%; HHV-4 em 0,3%, HHV-5 em 0,3%, HHV-6 em 0,7% e HAdV em 13%. Através da PCR em tempo real os HEV foram detectados em 23,3% e HSV em 5,1%. Por neutralização, somente duas amostras fora

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Waltl, Inken [Verfasser]. "The role of brain infiltrating monocytes and resident microglia in a mouse model of viral encephalitis induced acute seizures and epilepsy / Inken Waltl." Hannover : Stiftung Tierärztliche Hochschule Hannover, 2019. http://d-nb.info/1192752376/34.

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Vasconcelos, Rosemeri de Oliveira. "Participação da glia nas alterações morfológicas do cérebro e na produção de "beta"-quimiocinas na encefalite experimental pelo vírus da estomatite vesicular em camundongos /." Jaboticabal : [s.n.], 2003. http://hdl.handle.net/11449/104671.

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Orientador: Antonio Carlos Alessi<br>Banca: Rosangela Zacarias Machado<br>Banca: José Luiz Guerra<br>Banca: João Santana da Silva<br>Banca: Valéria Marçal Felix de Lima<br>Resumo: A compreensão do comportamento da microglia frente a uma injúria viral contribui para o entendimento da dimensão da rede de comunicação celular, durante um processo degenerativo ou inflamatório no SNC. Pesquisas que utilizam modelos experimentais com o vírus da estomatite vesicular (VEV) têm colaborado com informações importantes sobre o comportamento e distribuição do agente no encéfalo, e também sobre o papel da re

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Brito, Glauber da Costa de. "Avaliação imunológica de vacina de polissacarídeo meningocócico C conjugado e encapsulado em lipossomo." Universidade de São Paulo, 2002. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-21122015-154357/.

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A tecnologia de conjugação melhorou a imunogeniddade de vacinas constituídas de polissacarídeo, especialmente em crianças. Polissacarídeos conjugados a proteínas carregadoras, como o toxóide tetânico, induzem resposta imunológica dependente de célula T e memória imunológica de longa duração. No entanto, esta tecnologia apresenta custo elevado. Assim, foi investigada a capaddade dos lipossomos de aumentar a resposta imunológica ao polissacarídeo C de Neisseria meningitidis (PSC). Camundongos foram imunizados com Iipossomos contendo PSC, conjugado toxóide tetânico-PSC ou PSC livre como controle,

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Khumalo, Jermaine. "The use of molecular diagnostic methods to improve the detection of the common bacterial and viral causes of community acquired meningitis in children in South Africa." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/15539.

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With conventional methods of diagnosis, substantial overlaps are common due to an absence of the expected CSF findings clearly aligning to bacterial or viral infection. Reduced sensitivity is commonly observed chiefly due to empiric antibiotic treatment leading to bacterial culture negative results. This leads to costly hospital admissions and unnecessarily prolonged treatment for the unexplained aetiology, further compounded by routine viral diagnostics not being commonly implemented for meningitis diagnosis. We developed and validated in-house quantitative real-time (qPCR) multiplex assays t

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Коленко, Оксана Іванівна, Оксана Ивановна Коленко, Oksana Ivanivna Kolenko та Л. Є. Бражник. "Вірусні енцефаліти з атиповим перебігом". Thesis, Видавництво СумДУ, 2008. http://essuir.sumdu.edu.ua/handle/123456789/3702.

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Атиповість випадків енцефаліту дає можливість прийти до висновку, що поряд з симптомами ураження головного мозку розвиваються прогресуючі міастенічні розлади. Психопатологічна симптоматика дебютувала без запального анамнезу і неврологічного дефіциту. Раннє обстеження хворих дає можливість своєчасно діагностувати вірусні енцефаліти. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/3702

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Miller, James A. C. "Expression of potential vaccine antigens in plants." Thesis, Queensland University of Technology, 2001.

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Volle, Romain. "Pathogénie des entérovirus : étude de la charge virale au cours de méningites et de la permissivité des cellules endothéliales microvasculaires cérébrales humaines." Thesis, Clermont-Ferrand 1, 2014. http://www.theses.fr/2014CLF1MM05/document.

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Les entérovirus humains (EV) constituent un groupe de virus à ARN d'une grande diversité génétique. Ils sont responsables d'infections cérébrales graves mais rares et de méningites bénignes mais fréquentes. Les évènements conduisant à l'entrée des EVs dans le système nerveux central (SNC), l'importance de la charge virale dans le liquide céphalo rachidien (LCR) et sa corrélation éventuelle avec l'intensité du processus inflammatoire réactionnel restent peu explorés. Comme de nombreux génotypes d'EV sont associés à des manifestations neurologiques semblables, des processus pathologiques communs

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Silva, Marcia Cristina da. "Neuropatologia da cinomose canina." Universidade Federal de Santa Maria, 2009. http://repositorio.ufsm.br/handle/1/4037.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Canine distemper is one of the most prevalent viral diseases of dogs. Several cases are diagnosed in a daily basis in private practices and veterinary hospitals around the country. Most cases of neurological manifestation of canine distemper are fatal and the diagnosis confirmation by histopathology is often necessary. Canine distemper encephalitis is the main cause of death or reason for euthanasia in dogs necropsied at the Laboratório de Patologia Veterinária (LPV) of the Universidade Federal de Santa Maria (UFSM). Consequently t

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Lalande, Alexandre. "Agrégation et fibrillation des facteurs de virulence W et V des virus Hendra et Nipah." Electronic Thesis or Diss., Lyon 1, 2024. http://www.theses.fr/2024LYO10223.

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Les virus Hendra et Nipah sont des pathogènes zoonotiques émergents à potentiel épidémique et pandémique. Leur haute virulence chez l’Homme, leur léthalité, l’absence de traitement et de vaccin, et le danger bioterroriste qu’ils pourraient représenter en font des virus de niveau maximal de biosécurité. Ces paramyxovirus sont responsables de syndromes respiratoires sévères et d’encéphalites pouvant atteindre des taux de létalité supérieures à 90%. Leur pathogénicité est sous-tendue notamment par l’expression de leurs facteurs de virulence W et V, des protéines virales spécialisées pour l’inhibi

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Mathews, Laure. "Vers une meilleure compréhension du risque de transmission alimentaire du virus de l'encéphalite à tiques par la consommation de produits laitiers non pasteurisés en France." Electronic Thesis or Diss., Maisons-Alfort, École nationale vétérinaire d'Alfort, 2024. http://www.theses.fr/2024ENVA0003.

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Le virus de l'encéphalite à tiques (TBEV) - genre Orthoflavivirus - est l'arbovirus le plus fréquent en Europe. Le sous-type européen affecte le système nerveux central chez l'homme et peut être fatal dans 0,5 à 2% des cas. L'homme s'infecte soit par la piqûre d'une tique infectée soit par l'ingestion de produits laitiers contaminés non pasteurisés, principalement de chèvre. Le virus circule naturellement entre la tique Ixodes ricinus et les rongeurs forestiers. La distribution du TBEV en France, plus restreinte que celle de son vecteur, est à ce jour méconnue et peut être plus importante que

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Driouich, Jean-Sélim. "Caractérisation de méthodes de génétique inverse innovantes et application au développement de vaccins vivants atténués de nouvelle génération du virus de l’encéphalite à tiques." Thesis, Aix-Marseille, 2019. http://theses.univ-amu.fr.lama.univ-amu.fr/191219_DRIOUICH_406oje214ynbzpg327elrge719ju_TH.pdf.

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Dans le contexte actuel, où l’émergence et la réémergence de pathogènes viraux, notamment d’arbovirus (virus transmis par des arthropodes), ne cessent de croître et constituent un problème majeur de santé publique, le développement de nouveaux outils thérapeutiques est indispensable. Parmi ces outils, les vaccins, notamment ceux vivants atténués, restent le meilleur moyen prophylactique face à ces menaces. Les techniques d’atténuation des vaccins actuellement commercialisés ne sont pas applicables à l’ensemble des pathogènes viraux. C’est ainsi que de nouvelles méthodes d’atténuation sont à l’

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Weng, Chia-Chen, and 翁嘉珍. "Viral replication analysis of Japanese encephalitis virus and discovery of RT-primer-independent amplification of viral cDNA." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/99395086874571100151.

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碩士<br>國立東華大學<br>生物技術研究所<br>95<br>Japanese encephalitis virus (JEV) possesses a single positive- stranded RNA genome of 10,976 nucleotides in length. Previous studies in our laboratory have reported the abundant accumulation of a 3'-terminal 521- to 523-nucleotides genome fragment named small RNA, representing the highly conserved region of the 3'-untranslated region, in JEV-infected cells. To address possible functions of the small RNA during viral replication, unit-length (i.e. 523-nt) sense- and antisense-small RNA were separately transfected into JEV-infected cells and the effects on plus

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Lu, Kai-Zen, and 呂鎧任. "Anti-viral activity of Pericarpium granati against Japanese encephalitis virus." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/47098277033892540449.

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碩士<br>中國醫藥大學<br>醫學檢驗生物技術學系碩士班<br>99<br>Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus with positive-sense single-stranded RNA genome. JEV infection is asymptomatic, only few cases have headache, fever, encephalitis, coma and even death. Treatment for JE is supportive and still lack of efficacy. Water extrats of Pericarpium granati (PG) is an traditional herbal therapeutic with antiviral activities. It was shown to inhibit influenza A virus replication in chicken embryos and herpes simplex viruses in cell culture. In this study, we intend to investigate the anti-JEV activities

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Lee, Eva. "Location of antigenic determinants and expression of the envelope glycoprotein of Murray Valley encephalitis virus." Phd thesis, 1990. http://hdl.handle.net/1885/143182.

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Addis, Siti Nor Khadijah. "Genetic and functional analysis of the proteolytic cleavage at the junction of the NS1 and NS2A proteins of Murray Valley encephalitis virus." Phd thesis, 2011. http://hdl.handle.net/1885/151244.

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Flaviviruses are a group of positive-strand RNA viruses of global significance. The flavivirus RNA genome encodes a single open reading frame that is directly translated into a single polyprotein and cleaved by host and virally encoded proteases prior to protein maturation. Hence, the proteolytic cleavage events play a central role in the process of viral gene expression in flaviviruses. Despite the importance of these events, the mechanism of proteolytic cleavage leading to the generation of the two non-structural proteins, NS1 and NS2A is poorly defined. Sequence comparisons among the flaviv

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Bhandari, Prakash. "Host Gene Expression Profiling of Japanese Encephalitis Virus Infected cells : Identification of Novel Pro- and Anti-viral Genes." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/2806.

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Japanese encephalitis virus (JEV), a mosquito-borne flavivirus is the causative agent of Japanese encephalitis (JE). The disease affects mostly children and around 30000– 50000 cases of JE and up to 15000 deaths are reported annually. No anti-viral drugs have been discovered against JE so far, but advances in our knowledge of the molecular biology of flaviviruses is propelling flaviviral drug research at an expeditious pace. Since JEV has a small genome which encodes for only ten proteins, there is dearth of potential drug targets. Researchers are now focusing on cellular interactomes, a compl

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Bhandari, Prakash. "Host Gene Expression Profiling of Japanese Encephalitis Virus Infected cells : Identification of Novel Pro- and Anti-viral Genes." Thesis, 2013. http://etd.iisc.ernet.in/handle/2005/2806.

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Japanese encephalitis virus (JEV), a mosquito-borne flavivirus is the causative agent of Japanese encephalitis (JE). The disease affects mostly children and around 30000– 50000 cases of JE and up to 15000 deaths are reported annually. No anti-viral drugs have been discovered against JE so far, but advances in our knowledge of the molecular biology of flaviviruses is propelling flaviviral drug research at an expeditious pace. Since JEV has a small genome which encodes for only ten proteins, there is dearth of potential drug targets. Researchers are now focusing on cellular interactomes, a compl

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Eckert, Isabel. "Untersuchungen zu Aquaporin 1 und Aquaporin 4 im Liquor von Patienten mit bakterieller und viraler Meningitis im Vergleich zu einer Kontrollgruppe." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-8825-9.

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Hintergrund: Die bakterielle Meningitis hat eine Letalität von 10-20%. Das Hirnödem stellt bei ca. 14 % der Erkrankten eine prognosebestimmende Komplikation dar. Ein aktueller Forschungsansatz umfasst die Bedeutung der Aquaporine für die Entwicklung, Aufrechterhaltung und Resorption der verschiedenen Hirnödemformen, insbesondere des zytotoxischen und des vasogenen Hirnödems. In dieser Arbeit wird untersucht, ob Aquaporin 1 und Aquaporin 4 im Liquor von Patienten mit bakterieller und viraler Meningitis, im Vergleich zu einer gesunden Kontrollgruppe, nachweisbar sind. Zudem sollte geklärt werden

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Shwetank, *. "Infection of Human Cell Lines by Japanese Encephalitis Virus : Increased Expression and Release of HLA-E, a Non-classical HLA Molecule." Thesis, 2013. http://etd.iisc.ac.in/handle/2005/3457.

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Japanese encephalitis virus (JEV) causes viral encephalitis in new born and young adults that is prevalent in different parts of India and other parts of South East Asia with an estimated 6000 deaths per year. JEV is a single stranded RNA virus that belongs to the Flavivirusgenus of the family Flaviviridae. It is a neurotropic virus which infects the central nervous system (CNS). The virus follows a zoonotic life-cycle involving mosquitoes and vertebrates, chiefly pigs and ardeid birds, as amplifying hosts. Humans are dead end hosts. After entry into the host following a mosquito bite, JEV inf

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Shwetank, *. "Infection of Human Cell Lines by Japanese Encephalitis Virus : Increased Expression and Release of HLA-E, a Non-classical HLA Molecule." Thesis, 2013. http://etd.iisc.ernet.in/2005/3457.

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Abstract:

Japanese encephalitis virus (JEV) causes viral encephalitis in new born and young adults that is prevalent in different parts of India and other parts of South East Asia with an estimated 6000 deaths per year. JEV is a single stranded RNA virus that belongs to the Flavivirusgenus of the family Flaviviridae. It is a neurotropic virus which infects the central nervous system (CNS). The virus follows a zoonotic life-cycle involving mosquitoes and vertebrates, chiefly pigs and ardeid birds, as amplifying hosts. Humans are dead end hosts. After entry into the host following a mosquito bite, JEV inf

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