Relevant bibliographies by topics / Viral Vector Technology

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Viral Vector Technology'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Viral Vector Technology"

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Metzner, Christoph, and Marianne Zaruba. "On the Relationship of Viral Particles and Extracellular Vesicles: Implications for Viral Vector Technology." Viruses 13, no. 7 (2021): 1238. http://dx.doi.org/10.3390/v13071238.

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Gene therapy vectors derived from different viral species have become a fixture in biomedicine, both for direct therapeutic intervention and as tools to facilitate cell-based therapies, such as chimeric antigen receptor-based immunotherapies. On the contrary, extracellular vesicles have only recently gained a massive increase in interest and, concomitantly, knowledge in the field has drastically risen. Viral infections and extracellular vesicle biology overlap in many ways, both with pro- and antiviral outcomes. In this review, we take a closer look at these interactions for the most prominent
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Stone, D., A. David, F. Bolognani, PR Lowenstein, and MG Castro. "Viral vectors for gene delivery and gene therapy within the endocrine system." Journal of Endocrinology 164, no. 2 (2000): 103–18. http://dx.doi.org/10.1677/joe.0.1640103.

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The transfer of genetic material into endocrine cells and tissues, both in vitro and in vivo, has been identified as critical for the study of endocrine mechanisms and the future treatment of endocrine disorders. Classical methods of gene transfer, such as transfection, are inefficient and limited mainly to delivery into actively proliferating cells in vitro. The development of viral vector gene delivery systems is beginning to circumvent these initial setbacks. Several kinds of viruses, including retrovirus, adenovirus, adeno-associated virus, and herpes simplex virus, have been manipulated f
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Sizemore, Rachel J., Sonja Seeger-Armbruster, Stephanie M. Hughes, and Louise C. Parr-Brownlie. "Viral vector-based tools advance knowledge of basal ganglia anatomy and physiology." Journal of Neurophysiology 115, no. 4 (2016): 2124–46. http://dx.doi.org/10.1152/jn.01131.2015.

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Viral vectors were originally developed to deliver genes into host cells for therapeutic potential. However, viral vector use in neuroscience research has increased because they enhance interpretation of the anatomy and physiology of brain circuits compared with conventional tract tracing or electrical stimulation techniques. Viral vectors enable neuronal or glial subpopulations to be labeled or stimulated, which can be spatially restricted to a single target nucleus or pathway. Here we review the use of viral vectors to examine the structure and function of motor and limbic basal ganglia (BG)
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Koshimizu, Yoshinori, Kaoru Isa, Kenta Kobayashi, and Tadashi Isa. "Double viral vector technology for selective manipulation of neural pathways with higher level of efficiency and safety." Gene Therapy 28, no. 6 (2021): 339–50. http://dx.doi.org/10.1038/s41434-020-00212-y.

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AbstractPathway-selective gene delivery would be critical for future gene therapy against neuropsychiatric disorders, traumatic neuronal injuries, or neurodegenerative diseases, because the impaired functions depend on neural circuits affected by the insults. Pathway-selective gene delivery can be achieved by double viral vector techniques, which combine an injection of a retrograde transport viral vector into the projection area of the target neurons and that of an anterograde viral vector into their somas. In this study, we tested the efficiency of gene delivery with different combinations o
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Hosseinkhani, Hossein, Abraham J. Domb, Ghorbanali Sharifzadeh, and Victoria Nahum. "Gene Therapy for Regenerative Medicine." Pharmaceutics 15, no. 3 (2023): 856. http://dx.doi.org/10.3390/pharmaceutics15030856.

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The development of biological methods over the past decade has stimulated great interest in the possibility to regenerate human tissues. Advances in stem cell research, gene therapy, and tissue engineering have accelerated the technology in tissue and organ regeneration. However, despite significant progress in this area, there are still several technical issues that must be addressed, especially in the clinical use of gene therapy. The aims of gene therapy include utilising cells to produce a suitable protein, silencing over-producing proteins, and genetically modifying and repairing cell fun
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Kreppel, Florian, and Claudia Hagedorn. "Episomes and Transposases—Utilities to Maintain Transgene Expression from Nonviral Vectors." Genes 13, no. 10 (2022): 1872. http://dx.doi.org/10.3390/genes13101872.

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The efficient delivery and stable transgene expression are critical for applications in gene therapy. While carefully selected and engineered viral vectors allowed for remarkable clinical successes, they still bear significant safety risks. Thus, nonviral vectors are a sound alternative and avoid genotoxicity and adverse immunological reactions. Nonviral vector systems have been extensively studied and refined during the last decades. Emerging knowledge of the epigenetic regulation of replication and spatial chromatin organisation, as well as new technologies, such as Crispr/Cas, were employed
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Zhu, Zihe. "Overview of CRISPR/Cas Gene Editing System and Its Carrier System." Highlights in Science, Engineering and Technology 73 (November 29, 2023): 406–12. http://dx.doi.org/10.54097/hset.v73i.14030.

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The CRISPR/Cas9 system, which is currently extensively employed in gene editing-related engineering, is a flexible immune system in bacteria and archaea that reacts to viruses, bacteriophages, and foreign DNA. Cas proteins can cut foreign DNA into small molecule fragments, which are then integrated into CRISPR arrays; When the relevant DNA invades again, it can be accurately identified and cut off. The discovery of the CRISPR system is a major breakthrough in biology because it operates more efficiently and concisely than the previous two generations of technology, providing a powerful tool fo
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Schnödt, Maria, Marco Schmeer, Barbara Kracher, et al. "DNA Minicircle Technology Improves Purity of Adeno-associated Viral Vector Preparations." Molecular Therapy - Nucleic Acids 5 (2016): e355. http://dx.doi.org/10.1038/mtna.2016.60.

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Saadi, Hogir. "Gene Therapy Approaches." Qubahan Academic Journal 1, no. 1 (2021): 52–56. http://dx.doi.org/10.48161/qaj.v1n1a35.

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Gene therapy can be described broadly as the transfer of genetic material to control a disease or at least to enhance a patient's clinical status. The transformation of viruses into genetic shuttles is one of the core principles of gene therapy, which will introduce the gene of interest into the target tissue and cells. To do this, safe strategies have been invented, using many viral and non-viral vector delivery. Two major methods have emerged: modification in vivo and modification ex vivo. For gene therapeutic approaches which are focused on lifelong expression of the therapeutic gene, retro
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Santos, Lana C., Antônio Márcio Santana Fernandes, Izabel Almeida Alves, et al. "Trends in Viral Vector-Based Vaccines for Tuberculosis: A Patent Review (2010–2023)." Vaccines 12, no. 8 (2024): 876. http://dx.doi.org/10.3390/vaccines12080876.

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Tuberculosis (TB) is an ancient global public health problem. Several strategies have been applied to develop new and more effective vaccines against TB, from attenuated or inactivated mycobacteria to recombinant subunit or genetic vaccines, including viral vectors. This review aimed to evaluate patents filed between 2010 and 2023 for TB vaccine candidates. It focuses on viral vector-based strategies. A search was carried out in Espacenet, using the descriptors “mycobacterium and tuberculosis” and the classification A61K39. Of the 411 patents preliminarily identified, the majority were related
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Dissertations / Theses on the topic "Viral Vector Technology"

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Ditto, Andrew. "DNA-LPEI complexes encapsulated in LTP nanospheres as a non-viral gene therapy vector." Akron, OH : University of Akron, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1165596983.

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Thesis (M.S.)--University of Akron, Dept. of Biomedical Engineering, 2006.<br>"December, 2006." Title from electronic thesis title page (viewed 12/31/2008) Advisor, Yang Yun; Committee members, Stephanie Lopina, Steven Schmidt; Department Chair, Daniel Sheffer; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
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Brugada, Vilà Pau. "Boosting intravenous administration of therapeutic viral vectors using an oligopeptide-modified poly(β-aminoester)s-based coating technology". Doctoral thesis, Universitat Ramon Llull, 2018. http://hdl.handle.net/10803/664008.

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En els últims anys, l’ús terapèutic de virus pel tractament de malalties genètiques i càncer ha esdevingut una realitat. La millor demostració és l’aprovació regulatoria, la comercialització i l’ús clínic d’alguns productes basats en virus. No obstant, encara no s’ha aconseguit desplegar tot el seu potencial. La inherent promiscuïtat dels virus per infectar cèl·lules indesitjades, la seva alta immunogenicitat i la alta seroprevalença de la població ha limitat el seu ús a tractaments administrats localment per garantir la seva seguretat i eficàcia. S’han explorat moltes estratègies per tal de s
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Books on the topic "Viral Vector Technology"

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Medeiros, Mauricio, Beatriz Fialho, Priscila Soares, and Daniel Lacerda, eds. A primeira vacina 100% brasileira contra a Covid-19: a conquista de Bio-Manguinhos/Fiocruz. Fundação Oswaldo Cruz / Bio-Manguinhos, 2022. http://dx.doi.org/10.35259/vacinacovid.2022_52830.

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The Covid-19 pandemic is a unique event in the modern history of humanity, which has generated great challenges and, at the same time, valuable opportunities for public health. A number of examples of them are found in the more than three hundred pages of this book. In each chapter it is possible to understand how a vaccine for Covid-19 was developed in record time - due to the urgency of an antidote that would allow us to deal with this terrible disease - through the acceleration, compliance and improvement of all labor criteria, production, evaluation, timely release, and security. This enti
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Book chapters on the topic "Viral Vector Technology"

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Sendresen, Cecilia, D. Fassnacht, C. Benati, and Ray Pörtner. "Possible Strategies for the Production of Viral Vector: The Role of Engineering Design." In Animal Cell Technology: From Target to Market. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0369-8_127.

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Müller, Katja, and Manfred Wirth. "A General Method for the On-Line RT-PCR Detection of Retrovirus Contamination in Cell Lines Used for Protein and Viral Vector Production." In Animal Cell Technology: From Target to Market. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0369-8_117.

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Babiuk, Shawn. "Emerging Viral-Vectored Technology: Future Potential of Capripoxvirus and African Swine Fever Virus as Viral Vectors." In Viral Vectors in Veterinary Vaccine Development. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-51927-8_14.

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Vasi, J., R. Morenweiser, K. Eriksson, R. Lemmens, and S. Herzer. "Ion-Exchange Chromatography Based Strategies for Purification of Viral Vectors." In Animal Cell Technology Meets Genomics. Springer Netherlands, 2005. http://dx.doi.org/10.1007/1-4020-3103-3_66.

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Hanff, C., B. Fuhr, T. Johnson, and Matthew Caple. "Medium for Gene Therapy: Improved Protein-Free Media for Growth and Production of Viral Vectors for Use in Gene Therapy." In Animal Cell Technology: From Target to Market. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0369-8_130.

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Zaharia C.N. and Cristea Al. "A micropopulational modelling of a viral epidemic by using a special neural network." In Studies in Health Technology and Informatics. IOS Press, 1999. https://doi.org/10.3233/978-1-60750-912-7-682.

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A general forward neural network was adapted for a simulation of viral epidemics. This involves the introduction of a strongly dependence upon history, upon the cumulated values of the corresponding neuron (individual) activations (states of infection) specifying the activation (health) states of the contaminated individuals, represented by the activated neurons and the dynamic parameters of the neural network: the matrix of the synaptic connection and the vector of the activation thresholds (corresponding to the matrix of the viral transfers between the various individuals and to the vector o
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L.G. Mahoney, Alexandra, Najah T. Nassif, Bronwyn A. O’Brien, and Ann M. Simpson. "Viral Vectors in Gene Therapy and Clinical Applications." In Molecular Cloning [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102559.

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Developments in gene therapy, coupled with advances in genome sequencing and a greater understanding of DNA sequences, have given rise to an exciting area of research. The use of viral vectors in gene therapy has become a very promising and fast-emerging technology over the past few decades. Despite previous setbacks, the approval of viral vector therapies worldwide, with many in late-stage clinical trials has led to a significant increase in research in this area of gene therapy. Retroviral, adenoviral, adeno-associated viral, and lentiviral vectors are all key vectors currently being researc
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Mushtaq, Iqra, Ammara Chaudhry, and Muhammad Sajjad Sarwar. "Wolbachia: From Natural Variation to Genetic Engineering – Exploring Gene-Level Approaches for Next-Generation Dengue Control." In Viral Replication and Production [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.1009796.

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Dengue fever poses a significant global health challenge, particularly in tropical and subtropical regions. Current control strategies, heavily reliant on vector control, face limitations due to insecticide resistance and logistical challenges in large urban areas. This book chapter explores the innovative potential of Wolbachia bacteria as a biocontrol agent against dengue. Wolbachia infection in Aedes aegypti mosquitoes, the primary dengue vector, has demonstrated promising results in reducing both viral replication within the mosquito and onward transmission to humans. This chapter examines
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Richardson, J. H., and A. M. L. Lever. "Vectors based on HIV." In HIV. Oxford University PressOxford, 1995. http://dx.doi.org/10.1093/oso/9780199634934.003.0006.

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Abstract Retroviral vectors based on murine and avian retroviruses are widely used as an efficient method of gene transfer into mitotic cells (1). They have the advantages of: stable, single copy gene insertion into a host cell chromosome minimal toxicity and cytopathicity targeted gene transfer into cells bearing the appropriate viral receptor suitability for use in vivo Recently, retroviral vector technology has been taken into clinical use with Moloney murine leukaemia virus (M-MuLV) vectors being used as the mode of gene delivery in the first trials of human gene therapy. Vectors derived f
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Friedmann, Theodore. "Genetics—from a descriptive to a manipulative science." In The Origin and Development of Genetic Therapies. Oxford University PressNew York, 2025. https://doi.org/10.1093/med/9780197689974.003.0014.

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Abstract In 1972, Friedmann and Roblin proposed applications for the emerging field of recombinant DNA technology to develop virus-vector approaches to human gene therapy. The following years witnessed the development of gene transfer vectors based on recombinant engineered retroviruses, lentiviruses, adenoviruses, adeno-associated viruses, enteroviruses, foamy viruses, herpes viruses and a variety of other mammalian viruses that showed various degrees of gene transfer efficiency and safety in preclinical studies. Of all these viral transducing agents, recombinant retro- and lentiviruses and a
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Conference papers on the topic "Viral Vector Technology"

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Inose, Tomoko. "Plasmonic nanowire based intracellular material delivery." In JSAP-Optica Joint Symposia. Optica Publishing Group, 2024. https://doi.org/10.1364/jsapo.2024.16p_b4_1.

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The technology for introducing biomolecules such as proteins and DNA into cells is widely used as a method to artificially control cell functions, ranging from basic biology to the pharmaceutical field. Methods employing liposomes, viral vectors, and the electroporation have been currently widely used, although these methods show low introduction efficiency or cell toxicity to some cell types. Another method for introducing biomolecules into cells is microinjection.1) This method physically introduces micro/nano needles directly into the cells, ensuring that biomolecules are reliably delivered
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Mintaev, R. R., D. V. Glazkova, O. V. Orlova, F. A. Urusov, G. A. Shipulin, and E. V. Bogoslovskaya. "DEVELOPMENT OF THE TECHNOLOGY PLATFORM BASED ON THE MODIFIED VACCINIA ANKARA FOR RAPID PRODUCTION OF VECTOR VACCINES." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-194.

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Infectious diseases, including viral diseases, are a major cause of death and disability. Vaccination is the most effective means of protection, but the efficacy and safety of vaccines are often unsatisfactory. The aim of this study is to develop methods for the rapid production of immunogenic MVA-based vector vaccines against RNA viruses. We created candidate vaccines against influenza virus and against dengue virus based on MVA vector.
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Dias, Heike Felipe Rangel, Rennyson Siqueira do Amaral, Marina Rosan Costa, Fernanda Melo Oliveira, José Henrique Amaral dos Santos, and Gabriela Capalbo Garrote. "Advances in gene therapy for neuromuscular diseases." In III Seven International Medical and Nursing Congress. Seven Congress, 2024. http://dx.doi.org/10.56238/iiicongressmedicalnursing-041.

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Gene therapy has shown significant potential in the treatment of neuromuscular diseases such as Duchenne muscular dystrophy and spinal muscular atrophy. Advances in viral vector technology and gene editing techniques such as CRISPR-Cas9 have opened up new therapeutic possibilities. This paper explores the main advances, clinical outcomes and challenges associated with the application of this therapeutic approach. The literature review is based on recent studies on innovations in the field of gene therapy.
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Chaudhari, Parag, Purushottam Gangsar, Nitin Dharmadhikari, Sachin Pawar, and Devendra Mandke. "Intelligent Diagnosis for Fuel Line Fault of Diesel Engine Based on Vibration Signatures." In Symposium on International Automotive Technology. SAE International, 2024. http://dx.doi.org/10.4271/2024-26-0221.

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&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Early fault detection is vital in maintaining system stability and to decrease the cost associated with maintenance. This paper presents an approach to identify the fuel line failure for a diesel engine based on vibration signals and machine learning. Vibration measurements are performed on the fuel line of the engine for both normal and faulty conditions for engine ramp up condition. After acquiring the time domain vibration signals, various features were extracted and have been analyzed in time and time-frequency domai
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Roy, Vishnu, Anurag Pandey, Amit Saxena, and Shivanjali Sharma. "Assessment of Machine Learning Techniques for Real-Time Prediction of Equivalent Circulating Density." In Offshore Technology Conference Asia. OTC, 2022. http://dx.doi.org/10.4043/31523-ms.

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Abstract The equivalent circulating density (ECD) is crucial in avoiding fluid losses or kicks while drilling. It's more critical in wells where the pore pressure gradient is close to the fracture pressure gradient. The conservation of mass and momentum determine the ECD, but this method does not account for other factors like torque, rotating speed, weight on bit, etc. These may affect the ECD directly or indirectly. The aim of this study is a practicality to predict the ECD using various machine learning techniques and to determine their effectiveness. The complete drilling dataset of an oil
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BuKhamseen, N. Y., M. Maucec, A. Aneddame, and H. H. Mohammadi. "Machine Learning-Enabled Classification System to Screen and Rank Horizontal Wells by Sidetracking Success Criteria." In International Petroleum Technology Conference. IPTC, 2024. http://dx.doi.org/10.2523/iptc-24355-ea.

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Abstract Sidetracking vertical wellbores into horizontal laterals to avoid or delay water coning is a common practice in managing oil reservoirs under water flooding. Accurately predicting if the sidetrack would improve the performance of the well (i.e., reduce water production, increase oil production, or both) represents a vital information to decide whether it is optimal to sidetrack or continue with current vertical hole and withstand the increasing water cut. In this paper, we employ algorithms of predictive analytics and machine learning (ML) on a large synthetic but realistic data set o
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Ghasemzadeh, Pejman, Subharthi Banerjee, Michael Hempel, Hamid Sharif, and Tarek Omar. "Evaluation of Machine Learning-Driven Automatic Modulation Classifiers Under Various Signal Models." In 2020 Joint Rail Conference. American Society of Mechanical Engineers, 2020. http://dx.doi.org/10.1115/jrc2020-8091.

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Abstract Automatic Modulation Classification (AMC) is becoming an essential component in receiver designs for next-generation communication systems, such as Cognitive Radios (CR). AMC enables receivers to classify an intercepted signal’s modulation scheme without any prior information about the signal. This is becoming increasingly vital due to the combination of congested frequency bands and geographically disparate frequency licensing for the railroad industry across North America. Thus, a radio technology is needed that allows train systems to adapt automatically and intelligently to changi
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Verma, Chaman, Zoltan Illes, and Veronika Stoffova. "NATION-WISE AFFILIATION PREDICTION FOR THE REAL-TIME." In eLSE 2020. University Publishing House, 2020. http://dx.doi.org/10.12753/2066-026x-20-121.

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To support the real-time prediction of the student demographic features such as gender, age, study level etc., in different type of online surveys and questionnaires machine learning played a vital role. In this paper, the author's applied a five supervised machine learning algorithms to predict the student's association with their home land (native) towards the technology used in their university. For this, a primary dataset has been collected with google form from the two country university (Indian and Hungarian. The present model might be useful to identify the student category based on the
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Lakhan, Mukhtiar Ahmed, Abdul Bari, Duria Sharif, et al. "Data Integrated Analysis of Flexural Attenuation and Sonic P&S Waves Defining the Future Drilling Strategy for an Exploratory Block in Pakistan." In Gas & Oil Technology Showcase and Conference. SPE, 2023. http://dx.doi.org/10.2118/214277-ms.

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Abstract Reservoir or nonreservoir geomechanics is pivotal to drilling safe and fit-for-purpose boreholes that lead to sustainable operations in the well lifecycle. Accordingly, a 1D mechanical earth model (MEM) plays a crucial role in guiding the exploration to production lifecycle with applications ranging from mud-weight optimization to hydraulic fracture designing. While numerous other petrophysical logs are critical inputs to the MEM, sonic compressional (P) and shear (S) slowness play a direct role in model building, as several geomechanics parameters are derived using them. In cased hol
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Jenkins, Michael, Calvin Leather, and Sean Kelly. "Satellite-Assisted Continuous Roving Unmanned IoT/RF Sensor Enhanced Robot (SATCRUISER) for AI Data Generation - Preliminary Findings." In AHFE 2023 Hawaii Edition. AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1004308.

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The proliferation of Internet of Things (IoT) devices has revolutionized the landscape of facility and supply chain security, offering unprecedented opportunities for real-time monitoring, proactive threat detection, and enhanced operational resilience. However, the increasing adoption of IoT devices in the context of facility and supply chain security has resulted in novel implications for safeguarding assets and mitigating risks. The dynamic nature of modern facilities and complex supply chains demands robust security measures to safeguard assets, prevent disruptions, and ensure operational
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Reports on the topic "Viral Vector Technology"

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Mawassi, Munir, and Valerian V. Dolja. Role of the viral AlkB homologs in RNA repair. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7594396.bard.

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AlkB proteins that repair DNA via reversing methylation damage are conserved in a broad range of prokaryotes and eukaryotes including plants. Surprisingly, AlkB-domains were discovered in the genomes of numerous plant positive-strand RNA viruses, majority of which belong to the family Flexiviridae. The major goal of this research was to reveal the AlkB functions in the viral infection cycle using a range of complementary genetic and biochemical approaches. Our hypotheses was that AlkB is required for efficient replication and genetic stability of viral RNA genomes The major objectives of the r
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