Relevant bibliographies by topics / Visceral Leishmaniasis (VL) elimination

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Academic literature on the topic 'Visceral Leishmaniasis (VL) elimination'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Visceral Leishmaniasis (VL) elimination"

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Chakravarty, Jaya, Amartya Seth, and Shyam Sundar. "Visceral leishmaniasis: Recent updates." Annals of Medical Science & Research 4, Suppl 1 (2025): S53—S59. https://doi.org/10.4103/amsr.amsr_57_24.

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Abstract Visceral leishmaniasis (VL), a severe neglected tropical disease, presents a substantial global health burden, with an estimated 1 million new cases annually. Although cutaneous leishmaniasis (CL) is more prevalent, VL is the deadliest form, particularly in regions such as the Indian subcontinent, East Africa, and Brazil. The disease is caused by Leishmania donovani and transmitted through infected sandflies. Advances in VL management have significantly reduced the number of cases, particularly in India, Nepal, and Bangladesh. However, challenges persist due to human immunodeficiency
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Deepak, Kuldeep Singh, Monal Trisal, Jyoti Mishra, and Ashish Sinha. "Community-based active case detection of hidden visceral leishmaniasis and post-kala-azar dermal leishmaniasis cases to support the elimination of visceral leishmaniasis in Bihar, India." MGM Journal of Medical Sciences 12, no. 2 (2025): 259–66. https://doi.org/10.4103/mgmj.mgmj_65_25.

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Abstract Background: Visceral leishmaniasis (VL), commonly known as kala azar, remains a serious parasitic disease and a critical public health concern in India. Bihar alone accounts for nearly 70% of the global VL burden. Despite sustained elimination efforts, the disease persists, primarily due to underreporting and undiagnosed cases, particularly post-kala-azar dermal leishmaniasis (PKDL), which serves as a concealed reservoir for continued transmission. Methods: Between February 2016 and February 2019, the Government of Bihar, in collaboration with multiple partners, implemented a proactiv
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Singh, Om Prakash, and Shyam Sundar. "Developments in Diagnosis of Visceral Leishmaniasis in the Elimination Era." Journal of Parasitology Research 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/239469.

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Visceral leishmaniasis (VL) is the most devastating parasitic infection worldwide causing high morbidity and mortality. Clinical presentation of VL ranges from asymptomatic or subclinical infection to severe and complicated symptomatic disease. A major challenge in the clinical management of VL is the weakness of health systems in disease endemic regions. People affected by VL mostly present to primary health care centers (PHCs), often late in their therapeutic itinerary. PHC physicians face a major challenge: they do not deal with a single disease issue but with patients presenting with compl
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SUNDAR, SHYAM, and ANUP SINGH. "Chemotherapeutics of visceral leishmaniasis: present and future developments." Parasitology 145, no. 4 (2017): 481–89. http://dx.doi.org/10.1017/s0031182017002116.

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SUMMARYTreatment of Visceral Leishmaniasis (VL), a neglected tropical disease, is very challenging with few treatment options. Long duration of treatment and drug toxicity further limit the target of achieving VL elimination. Chemotherapy remains the treatment of choice. Single dose of liposomal amphotericin B (LAmB) and multidrug therapy (LAmB + miltefosine, LAmB + paromomycin (PM), or miltefosine + PM) are recommended treatment regimen for treatment of VL in Indian sub-continent. Combination therapy of pentavalent antimonials (Sbv) and PM in East Africa and LAmB in the Mediterranean region/S
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Martschew, Eva, Ahmed Asa’ad Al-Aghbari, Anand Ballabh Joshi, et al. "Visceral leishmaniasis in new foci areas of Nepal: Sources and extent of infection." Journal of Vector Borne Diseases 60, no. 4 (2023): 414–20. http://dx.doi.org/10.4103/0972-9062.383637.

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Background & objectives: The successful elimination program of visceral leishmaniasis (VL) in Nepal decreased the incidence to less than 1 per 10,000 population leading to the consolidation phase. However, new VL cases have been recorded from new districts, threatening the elimination goal. This study monitors the geographical spread of VL and identifies potential risk factors. Methods: VL data of 2017–2020 were obtained from the Epidemiology and Disease Control Division (EDCD) of Nepal and mapped. Telephonic interviews with 13 VL patients were conducted. Results: The incidence maps indica
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Deb, Rinki M., Michelle C. Stanton, Geraldine M. Foster, et al. "Visceral leishmaniasis cyclical trends in Bihar, India – implications for the elimination programme." Gates Open Research 2 (February 21, 2018): 10. http://dx.doi.org/10.12688/gatesopenres.12793.1.

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Background:Visceral leishmaniasis (VL) is a vector-borne disease of public health importance in India, with the highest burden of disease in the states of Bihar, Jharkhand, West Bengal and Uttar Pradesh. The disease is currently targeted for elimination (annual incidence to less than one per 10,000 population) using indoor residual spraying, active case detection and treatment. Historically the disease trend in India has been regarded as cyclical with case resurgence characteristically occurring every 15 years. Understanding this pattern is essential if the VL elimination gains are to be susta
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Uranw, Surendra, Narayan Raj Bhattarai, Kristien Cloots, et al. "Visceral leishmaniasis in the hills of western Nepal: A transmission assessment." PLOS ONE 19, no. 4 (2024): e0289578. http://dx.doi.org/10.1371/journal.pone.0289578.

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In Nepal, visceral leishmaniasis (VL) has been targeted for elimination as a public health problem by 2026. Recently, increasing numbers of VL cases have been reported from districts of doubtful endemicity including hills and mountains, threatening the ongoing VL elimination program in Nepal. We conducted a multi-disciplinary, descriptive cross-sectional survey to assess the local transmission of Leishmania donovani in seven such districts situated at altitudes of up to 1,764 meters in western Nepal from March to December 2019. House-to-house surveys were performed for socio-demographic data a
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Le Rutte, Epke A., Luc E. Coffeng, Johanna Muñoz, and Sake J. de Vlas. "Modelling the impact of COVID-19-related programme interruptions on visceral leishmaniasis in India." Transactions of The Royal Society of Tropical Medicine and Hygiene 115, no. 3 (2021): 229–35. http://dx.doi.org/10.1093/trstmh/trab012.

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Abstract Background In March 2020, India declared a nationwide lockdown to control the spread of coronavirus disease 2019. As a result, control efforts against visceral leishmaniasis (VL) were interrupted. Methods Using an established age-structured deterministic VL transmission model, we predicted the impact of a 6- to 24-month programme interruption on the timeline towards achieving the VL elimination target as well as on the increase of VL cases. We also explored the potential impact of a mitigation strategy after the interruption. Results Delays towards the elimination target are estimated
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Ranasinghe, Shalindra, Deepika Fernando, Nayana Gunathilaka, Kanchana Mallawaarachchi, and Rajitha Wickremasinghe. "Leishmaniasis in Sri Lanka: Surmounting obstacles toward achieving elimination as a public health problem by 2028." Annals of Medical Science & Research 4, Suppl 1 (2025): S93—S102. https://doi.org/10.4103/amsr.amsr_36_24.

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Abstract In the 1990s, Sri Lanka started reporting cases of cutaneous leishmaniasis (CL), which gradually increased to the current case incidence rate of over 3000/year. The causative strain of CL is Leishmania donovani MON-37, which is genetically different from the visceral leishmaniasis (VL)-causing strain in Sri Lanka. Visceral and mucosal forms are rare in Sri Lanka. The potential vector is Phlebotomus argentipes. Due to increasing CL case numbers, the Anti-Malaria Campaign was identified as the focal point in 2022 by the Ministry of Health (MoH) to control leishmaniasis and a WHO-funded
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Chapman, Lloyd A. C., Simon E. F. Spencer, Timothy M. Pollington, et al. "Inferring transmission trees to guide targeting of interventions against visceral leishmaniasis and post–kala-azar dermal leishmaniasis." Proceedings of the National Academy of Sciences 117, no. 41 (2020): 25742–50. http://dx.doi.org/10.1073/pnas.2002731117.

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Understanding of spatiotemporal transmission of infectious diseases has improved significantly in recent years. Advances in Bayesian inference methods for individual-level geo-located epidemiological data have enabled reconstruction of transmission trees and quantification of disease spread in space and time, while accounting for uncertainty in missing data. However, these methods have rarely been applied to endemic diseases or ones in which asymptomatic infection plays a role, for which additional estimation methods are required. Here, we develop such methods to analyze longitudinal incidence
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Dissertations / Theses on the topic "Visceral Leishmaniasis (VL) elimination"

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Bunn, Patrick. "Immune Regulation during Experimental Visceral Leishmaniasis." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/366039.

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Visceral Leishmaniasis (VL) is a chronic infectious disease caused by the protozoan parasites Leishmania donovani and L. infantum (chagasi) responsible for significant morbidity and mortality in the developing world. Transmitted by sand fly vectors, Leishmania parasites preferentially infect host macrophages throughout the viscera. Experimental L. donovani infection in genetically susceptible mice elicits a highly organ-specific outcome that mirrors much of the immunopathology observed in human VL patients. In this context, the liver is a site of an acute, resolving infection whereas parasite
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Lim, DaJull [Verfasser], Ursula [Akademischer Betreuer] Wittwer-Backofen, and Franz-Josef [Akademischer Betreuer] Brüggemeier. "Barriers of visceral leishmaniasis reporting and surveillance in Nepal : : comparison of governmental VL-program districts with non-program districts." Freiburg : Universität, 2017. http://d-nb.info/1158495188/34.

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Tai, Nahla Omer Ahmed El. "Molecular approaches to direct diagnosis and characterization of Leishmania donovani in clinical isolates." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2003. http://dx.doi.org/10.18452/14845.

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Die vorliegende Studie wurde in einer Gruppe von Dörfern im Ostsudan, Gedaref State, durchgeführt. Bei 100 Patienten mit der Verdachtsdiagnose Kala Azar- oder Post-Kala Azar- Leishmaniose war der Erregernachweis mit der PCR direkt in klinischen Proben, die auf Filterpapier aufgebracht worden waren, ohne vorherige Kultivierung erfolgreich. In dieser PCR wurden die ribosomalen, internal transcribed spacer (ITS1 & ITS2) amplifiziert, weil sie sehr variabel sind, eine klare Speziesidentifizierung gestatten und bei weiterführenden Analysen der PCR-Produkte auch der Nachweis stammspezifischer Unters
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Beshah, Abate Mulugeta. "Clinical manifestations and anthropometric profiles of visceral leishmaniasis in selected centres in Ethiopia." Diss., 2011. http://hdl.handle.net/10500/8607.

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Visceral leishmaniasis is a severe systemic illness and early case management is important for the avoidance complications and control of the disease. Improving health workers’ knowledge on leishmaniasis is essential in improving the control programme. A quantitative, retrospective study of patient records and descriptive, explorative study of health care professionals’ knowledge on leishmaniasis were conducted. Data was collected from patient records (n=299) using a structured audit tool and from health care professionals (n=55) by means of a structured questionnaire. The study finding
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"Mathematical Modeling of Systematic Treatment Implementation and Dynamics of Neglected Tropical Diseases: Case Studies of Visceral Leishmaniasis & Soil-Transmitted Helminths." Doctoral diss., 2020. http://hdl.handle.net/2286/R.I.57414.

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abstract: Neglected tropical diseases (NTDs) comprise of diverse communicable diseases that affect mostly the developing economies of the world, the “neglected” populations. The NTDs Visceral Leishmaniasis (VL) and Soil-transmitted Helminthiasis (STH) are among the top contributors of global mortality and/or morbidity. They affect resource-limited regions (poor health-care literacy, infrastructure, etc.) and patients’ treatment behavior is irregular due to the social constraints. Through two case studies, VL in India and STH in Ghana, this work aims to: (i) identify the additional and potentia
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Books on the topic "Visceral Leishmaniasis (VL) elimination"

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National strategic guideline on Kala-azar elimination program in Nepal 2010. Epidemiology and Disease Control Division, 2010.

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Book chapters on the topic "Visceral Leishmaniasis (VL) elimination"

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Salotra, Poonam, Himanshu Kaushal, and V. Ramesh. "Containing Post Kala-Azar Dermal Leishmaniasis (PKDL): Pre-requisite for Sustainable Elimination of Visceral Leishmaniasis (VL) from South Asia." In Kala Azar in South Asia. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-47101-3_2.

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Ranjan, Ravi, Shobha Kumari, and Ashish Kumar. "Geographical Distribution of VL and PKDL in India." In Visceral Leishmaniasis and Post-kala-azar Dermal Leishmaniasis. CRC Press, 2025. https://doi.org/10.1201/9781032643120-2.

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Badhwar, Surbhi, Angamuthu Selvapandiyan, and Niti Puri. "Essentials in Leishmaniasis Elimination." In Challenges and Solutions Against Visceral Leishmaniasis. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-6999-9_3.

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Tiwari, Ritesh Kumar, Gaurav Kumar Pandit, and Meenakshi Singh. "Public Health Implications and Challenges of VL and PKDL." In Visceral Leishmaniasis and Post-kala-azar Dermal Leishmaniasis. CRC Press, 2025. https://doi.org/10.1201/9781032643120-13.

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Saxena, Prashant, Madhvi Saxena, Anukrti Mishra, and K. Balashankar. "Review of Existing Control Measures for VL and PKDL." In Visceral Leishmaniasis and Post-kala-azar Dermal Leishmaniasis. CRC Press, 2025. https://doi.org/10.1201/9781032643120-12.

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Coelho, Eduardo A. F., and Myron Christodoulides. "Vaccines for Canine Leishmaniasis." In Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-24355-4_13.

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AbstractVisceral leishmaniasis is a zoonotic disease in many countries and dogs are considered the main domestic reservoir of Leishmania parasites, and the presence of infected animals represents a potential risk for human disease. In this chapter, we review the state-of-the-art of canine visceral leishmaniasis (CanL) vaccines, discussing the properties and problems associated with the few currently licensed and discontinued vaccines and looking forward to the development of new, more effective vaccines. Reducing the incidence of CanL through vaccination will improve canine health and welfare
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Yadav, Alok K., Niharika Gupta, Amogh A. Sahasrabuddhe, and Anuradha Dube. "Feasibility of Therapeutic Vaccine for the Management and Control of VL." In Challenges and Solutions Against Visceral Leishmaniasis. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-6999-9_15.

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Karunaweera, Nadira D., and Rajika Dewasurendra. "Atypical Leishmania donovani Infections in Sri Lanka: Challenges for Control and Elimination." In Challenges and Solutions Against Visceral Leishmaniasis. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-6999-9_8.

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Chauhan, Yogesh, Priyanka Madaan, and Manju Jain. "Emergence of Novel Leishmania Genetic Variants: A New Challenge to the Ongoing Leishmaniasis Elimination Program in the Indian Subcontinent." In Challenges and Solutions Against Visceral Leishmaniasis. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-99-6999-9_7.

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Kumar Mahto, Kaushal, Pooja Prasad, Mohan Kumar, Intzar Ali, Vikram Vohra, and Deepak Kumar Arya. "Visceral Leishmaniasis: An Overview and Integrated Analysis of the Current Status, Geographical Distribution and Its Transmission." In Leishmania Parasites [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.110567.

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Visceral leishmaniasis (VL) is a vector–borne disease transmitted by Phlebotomine sandflies, with up to 350 million people are at risk of developing infection globally. VL has a severe influence on the impoverished and undeveloped populations among several subcontinents. Early and accurate diagnosis and treatment remain crucial to the management of VL, which still depends on vector control. The present chapter objectives are to provide an overview of visceral leishmaniasis and to raise knowledge of the most recent progress in this condition’s management, treatment, and prevention. Additionally
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Conference papers on the topic "Visceral Leishmaniasis (VL) elimination"

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Wilson, JM, F. Chowdhury, S. Hassan, et al. "Prognostic models predicting clinical outcomes in patients diagnosed with visceral leishmaniasis: a systematic review." In MSF Scientific Days International 2024. MSF-USA, 2024. http://dx.doi.org/10.57740/9sthrqk.

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INTRODUCTION Visceral leishmaniasis (VL) is a neglected tropical disease prevalent in populations affected by poverty, war, and famine. Without effective treatment, death is the norm. Prognostic models, as used by Médecins Sans Frontières (MSF) in East Africa, are used to identify high-risk patients for intensive management, including hospital admission, treatment with liposomal amphotericin B, broad-spectrum antibiotics, and blood transfusions. We provide a comprehensive and objective resource for policymakers, healthcare providers, and investigators, by identifying, summarising, and appraisi
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Polesca, Helielton Júnior Martins, Josué Silva Aguiar, Luiz Felipe da Cruz Couto, and César Augusto da Silva. "Visceral Leishmaniasis and HIV co-infection: Epidemiological data in the Pernambuco - Bahia health network, 2007-2022." In IV Seven International Congress of Health. Seven Congress, 2024. http://dx.doi.org/10.56238/homeivsevenhealth-029.

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Visceral Leishmaniasis (VL) is a chronic systemic infection caused by the protozoan Leishmania, transmitted by the bite of the Lutzomyia longipalpis mosquito. VL-HIV co-infection, which results from the combination with the human immunodeficiency virus, is considered an emerging disease. This study presents epidemiological data on VL-HIV co-infection in the PEBA Network, from 2007 to 2022, based on records from the Notifiable Diseases Information System (SINAN). Sixty-two confirmed cases of co-infection were analyzed, most of them in men, concentrated mainly in Pernambuco and Bahia. The Juazei
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Lopes, Carllos Eduardo Ferreira, Eduardo Lisboa, Yanka Ribeiro, and Fabiane Queiroz. "A Patch-based Microscopic Image Analysis for Visceral Leishmaniasis Screening Using a Deep Metric Learning Approach." In Simpósio Brasileiro de Computação Aplicada à Saúde. Sociedade Brasileira de Computação - SBC, 2024. http://dx.doi.org/10.5753/sbcas.2024.2117.

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Human Visceral Leishmaniasis (VL) is a fatal disease in over 95% of untreated cases and predominantly affects populations with limited access to healthcare. Parasitological techniques are the gold standard for diagnosing VL. It involves the direct microscopic examination of the parasite amastigotes approximately 2–4µ m in diameter. However, this process can be time-consuming and labor-intensive, necessitating a high level of expertise. We propose a novel approach to the detection of these amastigotes by combining deep metric learning with supervised classification techniques. We outperform the
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Muhammed Hassan, Ghuffran, and Amjed Qays Ibrahim Alqaisi. "Effect of Cocos nucifera oil on Iraqi strains of Leishmania in-vitro." In X INTERNATIONAL CONGRESS OF PURE AND APPLIED TECHNOLOGICAL SCIENCES. Rimar Academy, 2023. http://dx.doi.org/10.47832/minarcongress10-3.

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Leishmaniasis is a disease spread by sand-fly vectors of Phlebotomus spp. It is classified as one of the 17 Neglected Tropical Diseases (NTDs) by the World Health Organization (WHO). It is considered a major invasive parasite among immunocompromised individuals. Leishmaniasis presents in various forms, including cutaneous leishmaniasis (CL), visceral leishmaniasis (VL), and mucocutaneous leishmaniasis (MCL). The rate of manifestation is contingent upon the species implicated and the immunological response elicited by the infection .To investigate the impact of different concentrations of Mediu
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Solomos, A., AM Musa, J. Mbui, et al. "Efficacy and safety of 14-day treatment with paromomycin and miltefosine for primary visceral leishmaniasis in eastern Africa: non-inferiority trial." In MSF Scientific Day International 2023. MSF-USA, 2023. http://dx.doi.org/10.57740/y4z2-pq54.

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INTRODUCTION The parasitic disease visceral leishmaniasis (VL) is most commonly caused by Leishmania donovani in eastern Africa, currently the region with highest burden worldwide. Current treatment for VL comprises the combination of sodium stibogluconate and paromomycin, SSG/PM; this is toxic, painful, and requires hospitalisation and daily injections. Treatments are urgently needed that are safe, effective, and appropriate for use in remote areas. METHODS We conducted a phase III open-label randomised non-inferiority trial in Ethiopia, Kenya, Sudan, and Uganda. The trial used a parallel-arm
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Schallig, Henk, Norbert van Dijk, Dawit Hagos, et al. "OA-62 Improved molecular diagnosis of visceral leishmaniasis (VL) using the mini direct on blood PCR Nucleic Acid Lateral Flow Immunoassay (dbPCR-NALFIA)." In Abstracts of The Eleventh EDCTP Forum, 7–10 November 2023. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/bmjgh-2023-edc.4.

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