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Journal articles on the topic 'White Blood Cell Interaction'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Campbell, James E., Richard N. Garrison, and El Rasheid Zakaria. "Clinical peritoneal dialysis solutions modulate white blood cell–intestinal vascular endothelium interaction." American Journal of Surgery 192, no. 5 (2006): 610–16. http://dx.doi.org/10.1016/j.amjsurg.2006.08.016.

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Keating, Friederike K., Saulius Butenas, Mark K. Fung, and David J. Schneider. "Platelet-white blood cell (WBC) interaction, WBC apoptosis, and procoagulant activity in stored red blood cells." Transfusion 51, no. 5 (2010): 1086–95. http://dx.doi.org/10.1111/j.1537-2995.2010.02950.x.

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3

Allick, Aliyah, Emily Rao, James F. Casella, et al. "Global White Matter Changes and Associations with Cognition in Pediatric Sickle Cell Disease." Blood 142, Supplement 1 (2023): 1146. http://dx.doi.org/10.1182/blood-2023-181143.

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Introduction: Sickle cell disease (SCD) is a genetic blood disorder affecting multiple organ systems, particularly the brain (Pinto, V.M. et al 2019). Neurocognitive deficits can occur in the presence or absence of overt brain injury, such as stroke or silent cerebral infarction (SCI). Using diffusion tensor imaging (DTI) metrics, multiple studies have identified widespread white matter alterations in individuals with SCD. DTI abnormalities, such as decreased fractional anisotropy (FA) and increased mean diffusivity (MD), have been associated with decreased processing speed in this population

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Hernáez, Álvaro, Camille Lassale, Sara Castro-Barquero, et al. "Mediterranean Diet and White Blood Cell Count—A Randomized Controlled Trial." Foods 10, no. 6 (2021): 1268. http://dx.doi.org/10.3390/foods10061268.

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We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × 109 leukocytes/L), mild leukopenia (<4.5 × 109 leukocytes/L), or severe leukopenia (<3.5 × 109 leukocytes/L) in individuals without the condition at baseline (n

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Köhler, Ole, Louisa G. Sylvia, Charles L. Bowden, et al. "White blood cell count correlates with mood symptom severity and specific mood symptoms in bipolar disorder." Australian & New Zealand Journal of Psychiatry 51, no. 4 (2016): 355–65. http://dx.doi.org/10.1177/0004867416644508.

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Objective: Immune alterations may play a role in bipolar disorder etiology; however, the relationship between overall immune system functioning and mood symptom severity is unknown. Methods: The two comparative effectiveness trials, the Clinical and Health Outcomes Initiatives in Comparative Effectiveness for Bipolar Disorder Study (Bipolar CHOICE) and the Lithium Treatment Moderate-Dose Use Study (LiTMUS), were similar trials among patients with bipolar disorder. At study entry, white blood cell count and bipolar mood symptom severity (via Montgomery-Aasberg Depression Rating Scale and Bipola

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Gangaraju, Radhika, Insu Koh, Marguerite R. Irvin, et al. "Peripheral Blood Cytopenia and Subsequent Risk of Cardiovascular Disease and Mortality." Blood 134, Supplement_1 (2019): 5002. http://dx.doi.org/10.1182/blood-2019-125956.

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INTRODUCTION: African-Americans (blacks) have higher risk of stroke and coronary heart disease (CHD) - collectively referred to here as cardiovascular disease (CVD), than Caucasian-Americans (whites). Though partly explained by traditional cardiovascular risk factors, half of the excess risk in blacks is not explained by known risk factors. Recent data suggest increased risk of CVD and mortality in individuals with clonal hematopoiesis, which often presents as cytopenia. Using peripheral blood cytopenia as a marker of clonal hematopoiesis, we examined the association between cytopenia and risk

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Sharma, Prerna, Moolchand Sharma, Divij Gupta, and Nimisha Mittal. "Detection of white blood cells using optimized qGWO." Intelligent Decision Technologies 15, no. 1 (2021): 141–49. http://dx.doi.org/10.3233/idt-200055.

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This paper presents an optimized quantum Grey Wolf Optimization algorithm (qGWO), which is an enhanced version of the Grey Wolf optimization algorithm for feature selection of blood cells, which can further used for the detection of WBCs. White blood cells count in the human body determines the immune system of the human body. A deviation in the count of WBCs from the normal cell count in the human body may indicate an abnormal condition. The proposed model uses a quantum grey wolf optimization algorithm for the detection of White Blood cells among the dataset of various types of blood cells.

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Ayoola, M. O., A. O. Oguntunji, and A. T. Babalola. "Variation in hematological, biochemical parameters and physiological adaptation of cockerel strains to transportation density in a hot tropical environment." Journal of Animal Science and Veterinary Medicine 5, no. 2 (2020): 72–79. http://dx.doi.org/10.31248/jasvm2019.156.

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One hundred and eight 8 weeks old Harco (black) and Nera (white) cockerel strains were randomly allotted in 2 x 3 factorial design experiment to investigate the response of cockerel strains transported at different densities in hot humid ecological zone of Nigeria. Birds were transported in two ventilated wooden cages with a motorbike on a rough road at 30 km/hr for 2 hours at three densities [Low density (LD) = 0.86 m2, Medium density (MD) = 0.64 m2, and High density (HD) = 0.48 m2] and each replicated three times. Blood samples were collected pre and post transportation. Physiological indice

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Kizhakayil, Dhanya, Abbirami Sathappan, Giusy Gentilcore, et al. "B-T Cell Interactions in GRAFT-Versus-Host Disease." Blood 136, Supplement 1 (2020): 38. http://dx.doi.org/10.1182/blood-2020-141277.

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Cytotoxic T cells (CTLs) and B cells engage distinct interactions in GVHD patients' blood and tissues, detectable in regular flow-cytometry screenings, by size and by double positive CD19-CD8 antibody markers (Deola, BMT 2017). B-CTL couplets are formed by alpha-betaTCR+ CD8+ CTLs preferentially targeting CD27+ CD19+ cells displaying an activated CD80 and CD86 phenotype. Interactions may last from 5 minutes to roughly 1 hour, and release a pattern of T cell attracting chemokines, as IP10, MIG, ITAC, which are also known GVHD biomarkers. To further unravel the mechanism of this cell interaction

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Adrianzen Herrera, Diego, Insu Koh, Radhika Gangaraju, Tomi Akinyemiju, and Neil A. Zakai. "Peripheral Blood Cytopenia and Risk of Cancer Mortality." Blood 138, Supplement 1 (2021): 177. http://dx.doi.org/10.1182/blood-2021-144793.

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Abstract Introduction: Unexplained peripheral blood cytopenia remains a challenge in clinical practice which requires sorting through an array of etiologies from transient abnormalities to premalignant conditions. Clonal hematopoiesis has established an association between cytopenia and hematologic cancer, likely caused by inflammatory responses leading to hematopoietic stress. Similar mechanisms may occur in other organ systems and lead to neoplasia as the link between inflammation and solid tumors is well known. Thus, cytopenia may represent an early marker of serious conditions, including m

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Margos, Gabriele, Sandra Navarette, Geoff Butcher, et al. "Interaction between Host Complement and Mosquito-Midgut-Stage Plasmodium berghei." Infection and Immunity 69, no. 8 (2001): 5064–71. http://dx.doi.org/10.1128/iai.69.8.5064-5071.2001.

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ABSTRACT After ingestion by mosquitoes, gametocytes of malaria parasites become activated and form extracellular gametes that are no longer protected by the red blood cell membrane against immune effectors of host blood. We have studied the action of complement onPlasmodium developmental stages in the mosquito blood meal using the rodent malaria parasite Plasmodium berghei and rat complement as a model. We have shown that in the mosquito midgut, rat complement components necessary to initiate the alternative pathway (factor B, factor D, and C3) as well as C5 are present for several hours follo

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Ukolova, A. V., D. V. Bykov, M. A. Akimushkina, et al. "Using an artificial neural network to recognize sturgeon blood cells in microscopic images." Timiryazev Biological Journal 2, no. 4 (2025): 83–93. https://doi.org/10.26897/2949-4710-2024-2-4-83-93.

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The article considers the labor intensity of the process of determining the white blood cell count of fish, which is simultaneously being highly significant and necessary in terms of monitoring the health of individuals. The authors present an approach to automating the compilation of the white blood cell count of fish (using sturgeon as an example) using a convolutional neural network model capable of recognizing and identifying cells in a microscopic blood image. The general scheme of hematopoiesis and standards for hematological parameters of sturgeon are considered. The procedure for prepa

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Delshad, Belal, Hamed Abadijoo, Hossein Simaee, et al. "Role of Post-Intraoperative Radiation Therapy Wound Fluids in Interaction with White Blood Cells on Cancer Cell Growth." Archives of Breast Cancer 11, no. 1 (2024): 89–95. http://dx.doi.org/10.32768/abc.20241189-95.

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Background: Intraoperative radiation therapy (IORT), is a motivating method which has been widely applied in breast cancer lumpectomy to exclude or reduce the requirement of external beam radiotherapy. Although its effect on destructing remaining vital cancer cells in tumor bed was approved, maintaining or draining post intraoperative radiation therapy wound fluids (PIWFs) is challenging. Moreover, the roles of immune cells in interaction with PIWFs (either in favor or against of therapeutic approaches) haven’t been studied before which is the main investigation of this paper. Methods: Surgica

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Härtl, Roger, Max B. Medary, Maximilian Ruge, Karl E. Arfors, and Jam Ghajar. "Early White Blood Cell Dynamics after Traumatic Brain Injury: Effects on the Cerebral Microcirculation." Journal of Cerebral Blood Flow & Metabolism 17, no. 11 (1997): 1210–20. http://dx.doi.org/10.1097/00004647-199711000-00010.

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Increasing clinical and experimental evidence suggests that traumatic brain injury (TBI) elicits an acute inflammatory response. In the present study we investigated whether white blood cells (WBC) are activated in the cerebral microcirculation early after TBI and whether WBC accumulation affects the posttraumatic cerebrovascular response. Twenty-four anesthetized rabbits had chronic cranial windows implanted 3 weeks before experimentation. Animals were divided into four experimental groups and were studied for 7 hours (groups I, IIa, and III) or 2 hours (group IIb). Intravital fluorescence vi

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Buckley, Paul R., Melek Akay, Esme Carpenter, et al. "Abstract C142: Differential single-cell spatial immune cell profiles and immune cell interactions identified within lymph nodes metastases of black and white women diagnosed with triple negative breast cancers." Cancer Epidemiology, Biomarkers & Prevention 33, no. 9_Supplement (2024): C142. http://dx.doi.org/10.1158/1538-7755.disp24-c142.

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Abstract Ethnic disparities in breast cancer (BC) outcomes have been reported, with lower survival rates among black women compared to white. Additionally, the unfavorable triple negative (TNBC) sub-type is more prevalent in black women and within this population, risk of mortality is again higher compared to white women. Biological contributors to this disparity are less clearly understood than socio-economic factors. Recent studies recognize different breast tumour immune microenvironments between black and white BC patients, necessitating further research into ethnicity-related differences

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Fay, Meredith E., David R. Myers, Amit Kumar, et al. "White Blood Cell Mechanics Mediate Glucocorticoid- and Catecholamine-Induced Demargination." Blood 122, no. 21 (2013): 3459. http://dx.doi.org/10.1182/blood.v122.21.3459.3459.

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Abstract After treatment with glucocorticoids (e.g. dexamethasone) or catecholamines (e.g. epinephrine), the white blood cell (WBC) count substantially increases. This is primarily due to WBCs shifting from the marginated to circulating pools (Nakagawa et al., Circulation, 2008) and is traditionally attributed to down-regulation of adhesion molecule expression (Weber et al., J Leukoc Biol, 2004).Recent research has described how mechanical properties determine the radial position of blood cells within the intravascular space (Reasor et. al, Ann Biomed Eng., 2013). In addition, because WBC dema

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Huang, Chao-Hsin, Chieh-Yu Hsieh, Chih-Wen Wang, et al. "Associations and Interactions between Heavy Metals with White Blood Cell and Eosinophil Count." International Journal of Medical Sciences 19, no. 2 (2022): 331–37. http://dx.doi.org/10.7150/ijms.68945.

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18

Fabron Junior, Antonio, José Orlando Bordin, Hélio Moraes-Souza, Edna FreyMüller, and Eliana Lages-Silva. "Removal of Trypanosoma cruzi by white cell-reduction filters: an electronmicroscopic study." Revista da Sociedade Brasileira de Medicina Tropical 32, no. 3 (1999): 223–27. http://dx.doi.org/10.1590/s0037-86821999000300001.

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White cell (WBC)-reduction filters have been shown to be effective in removing infectious agents from infected blood products. In this study, the mechanisms of Trypanosoma cruzi (T. cruzi) retention by WBC-reduction filters were assessed. Human packed red blood cell (PRBC) and platelet concentrate (PC) samples were contaminated with T. cruzi organisms (Y strain; 3.4 x 10(6)/ml), and then filtered using WBC-reduction experimental filters that provided about 3 log10 WBC removal. Transmission electron microscopy sections showed that T. cruzi parasites were removed from contaminated PRBC and PC sa

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Hünig, T. R. "The ligand of the erythrocyte receptor of T lymphocytes: expression on white blood cells and possible involvement in T cell activation." Journal of Immunology 136, no. 6 (1986): 2103–8. http://dx.doi.org/10.4049/jimmunol.136.6.2103.

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Abstract We have recently described a monoclonal antibody (mAb) to sheep erythrocytes, termed L180/1, that blocks the formation of E rosettes between human or sheep T lymphocytes and sheep red blood cells. The cell surface glycoprotein (GP) of 42,000 apparent m.w. recognized by mAb L180/1 was given the preliminary name T11 target structure or T11TS. In the present report, it is shown that T11TS is also expressed on sheep white blood cells, notably on activated T lymphocytes, that are shown to actively synthesize this cell surface GP. In addition, the mixed lymphocyte reaction between outbred s

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Yan, Xiao-Qiang, Ulla Sarmiento, Yu Sun, et al. "A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer." Blood 98, no. 13 (2001): 3793–99. http://dx.doi.org/10.1182/blood.v98.13.3793.

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Abstract Notch receptors mediate cell-fate decisions through interaction with specific ligands during development. The biological role of a novel Notch ligand, Dll4, in mice was explored by reconstituting lethally irradiated mice with bone marrow (BM) cells transduced with Dll4 retroviral vector. White blood cell and lymphocyte counts in Dll4-overexpressing mice were reduced at the early stage of reconstitution but increased significantly at approximately 10 weeks after BM transplantation. BM, spleen, lymph nodes, and peripheral blood ofDll4-overexpressing mice contained predominantly CD4+CD8+

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Sladkova, Evgeniya A. "Influence of the Purinergic Signalling System on the Properties of Human Blood Cells at Ageing." Journal of Medical and Biological Research, no. 1 (February 10, 2021): 51–57. http://dx.doi.org/10.37482/2687-1491-z043.

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Adenosine triphosphate (ATP) molecules and nucleotide derivatives contribute to a wide range of cellular reactions through the activation of A2 and P2 purinergic receptors located on the cell surface. Almost any type of cells expresses such receptors, including red blood cells and white blood cells. The study of purinergic transmission of signals mediating calcium mobilization, actin polymerization, chemotaxis, release of mediators, tissue oxygenation, cell maturation, cytotoxicity, cell death and cell–cell interactions in dynamics at different stages of ontogenesis is an important issue in bi

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Fukui, Sayato, Akihiro Inui, Mizue Saita, Daiki Kobayashi, and Toshio Naito. "Clinical prediction rule for bacteremia with pyelonephritis and hospitalization judgment: chi-square automatic interaction detector (CHAID) decision tree analysis model." Journal of International Medical Research 50, no. 1 (2022): 030006052110656. http://dx.doi.org/10.1177/03000605211065658.

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Objective This study was performed to identify predictive factors for bacteremia among patients with pyelonephritis using a chi-square automatic interaction detector (CHAID) decision tree analysis model. Methods This retrospective cross-sectional survey was performed at Juntendo University Nerima Hospital, Tokyo, Japan and included all patients with pyelonephritis from whom blood cultures were taken. At the time of blood culture sample collection, clinical information was extracted from the patients’ medical charts, including vital signs, symptoms, laboratory data, and culture results. Factors

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Zhang, Xiaotian, Margaret Goodell, Mira Jeong, Haley Gore, and Wanding Zhou. "A Gene Depleted DNA Methylation Canyon Maintains Hematopoietic Stem Cell Self-Renewal and NPM1c+ Leukemia By Regulating the Gene Expression of HOXA Cluster." Blood 132, Supplement 1 (2018): 649. http://dx.doi.org/10.1182/blood-2018-99-112962.

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Abstract DNA methylation Canyons (DMC in short, also referred to as DNA methylation Valleys) are long unmethylated regions (UMR) over 3.5kb, in the mammalian genome. DMCs are associated with homeotic genes and can be classified into active DMCs marked by H3K4me3 and repressive DMCs marked by H3K27me3. We performed high resolution in situ HiC on human hematopoietic stem and progenitor cells (HSPC) and differentiated red blood cell (RBC) progenitors derived from HSPC. We found that DMCs over 7.3kb form significant 3D micro-compartment interactions with each other. These interactions are extremel

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Rajalakshmi, T., and C. Senthilkumar. "Red Deer Optimization with Deep Learning based Robust White Blood Cell Detection and Classification Model." International Journal on Recent and Innovation Trends in Computing and Communication 11, no. 8 (2023): 107–24. http://dx.doi.org/10.17762/ijritcc.v11i8.7929.

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The use of deep learning techniques for White Blood Cell (WBC) classification has garnered significant attention on medical image analysis due to its potential to automate and enhance the accuracy of WBC classification, which is critical for disease diagnosis and infection detection. Convolutional neural networks (CNNs) have revolutionized image analysis tasks, including WBC classification effectively capturing intricate spatial patterns and distinguishing between different cell types. A key advantage of deep learning-based WBC classification is its capability to handle large datasets, enablin

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Boisseau, M. R., T. Khodabandehlou, and C. Le Dévéhat. "Fibrinolytic and biochemical factors in patients with venous insufficiency." Phlebology: The Journal of Venous Disease 19, no. 1 (2004): 7–13. http://dx.doi.org/10.1258/026835504773042211.

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Long-term metabolic changes in vein tissue of the limbs and feet have been reported in the course of chronic venous insufficiency (CVI). Low fibrinolytic potential was first demonstrated using fibrin-embedded vein rings (Todd's biopsy), then in blood via increased euglobulin lysis time. This defect is especially pronounced when blood is taken from foot veins of patients with grades 5 and 6 of CVI or skin lesions. Haemorrheological disorders such as increased blood viscosity and red cell aggregation, related mainly to high fibrinogen levels, have also been shown in patients with CVI. Such disor

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Song, Qingxiao, Xiaoning Wang, Xiwei Wu, et al. "Tolerogenic anti–IL-2 mAb prevents graft-versus-host disease while preserving strong graft-versus-leukemia activity." Blood 137, no. 16 (2021): 2243–55. http://dx.doi.org/10.1182/blood.2020006345.

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Abstract Donor T cells mediate both graft-versus-leukemia (GVL) activity and graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (allo-HCT). Development of methods that preserve GVL activity while preventing GVHD remains a long-sought goal. Tolerogenic anti–interleukin-2 (IL-2) monoclonal antibody (JES6-1) forms anti–IL-2/IL-2 complexes that block IL-2 binding to IL-2Rβ and IL-2Rγ on conventional T cells that have low expression of IL-2Rα. Here, we show that administration of JES6 early after allo-HCT in mice markedly attenuates acute GVHD while preserving GVL

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Ezekekwu, Chinedu A., Taiwo R. Kotila, Chinonso Chiemeka Anyanwu-Yeiya, Titilola S. Akingbola, and Bamidele Tayo. "The Interaction of Sickle Cell Trait and Anticardiolipin Antibodies in Venousthromboembolism." Blood 138, Supplement 1 (2021): 4261. http://dx.doi.org/10.1182/blood-2021-151564.

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Abstract Introduction Among the risk factors for venous thromboembolism (VTE) are inheritance of the sickle cell gene and antiphospholipid syndrome. Antiphospholipid antibodies are elevated in sickle cell disease but there is little information on its levels in sickle cell trait. The prevalence of anticardiolipin antibodies and association with VTE is equally not known in the Nigerian population. Methods A case control study involving 50 consecutive patients with Doppler confirmed venous thromboembolism at the University College Hospital Ibadan and 50 apparently healthy individuals. Haemoglobi

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Fang, Chunhui, and Henny Heisler Billett. "Race, ABO Blood Type, Gender, Age and Venous Thromboembolism Risk: Not Black and White." Blood 116, no. 21 (2010): 568. http://dx.doi.org/10.1182/blood.v116.21.568.568.

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Abstract Abstract 568 Venous thromboembolism (VTE) prevalence has been noted to be different for different racial groups: Non-Hispanic blacks tend to have a higher risk compared with non-Hispanic whites. Different ABO blood types have also been previously shown to be associated with different risk of VTE, with individuals with O blood type carry the lowest VTE risk. Given that blacks have a higher percentage of O blood type, one would expect to see a lower prevalence of VTE. In order to explain this paradoxical finding, we utilized the Clinical Looking Glass (CLG) system to study the relative

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de Jong, Jill L. O., Alan J. Davidson, Yuan Wang, et al. "Interaction of retinoic acid and scl controls primitive blood development." Blood 116, no. 2 (2010): 201–9. http://dx.doi.org/10.1182/blood-2009-10-249557.

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Abstract Hematopoietic development during embryogenesis involves the interaction of extrinsic signaling pathways coupled to an intrinsic cell fate that is regulated by cell-specific transcription factors. Retinoic acid (RA) has been linked to stem cell self-renewal in adults and also participates in yolk sac blood island formation. Here, we demonstrate that RA decreases gata1 expression and blocks primitive hematopoiesis in zebrafish (Danio rerio) embryos, while increasing expression of the vascular marker, fli1. Treatment with an inhibitor of RA biosynthesis or a retinoic acid receptor antago

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Livnjak, Amela, Nejra imusi, Hans Fuehrer, Bita Barogh, Jovana upi, and Lejla i. "<b>First molecular evidence of hemotropic <i>mycoplasmas</i> in goats from Bosnia and Herzegovina</b>." Open Veterinary Journal 15, no. 1 (2025): 270. https://doi.org/10.5455/ovj.2025.v15.i1.25.

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Background: Hemoplasmas represent the type of bacteria that infect red blood cells, potentially leading to various health impacts, including changes in blood parameters. The close interaction between hemoplasma and red blood cells results in cell damage through immune-related and other unspecified mechanisms. Even with a strong immune response and antibiotic treatment, affected animals are likely to remain chronic carriers once clinical symptoms have subsided. These microorganisms were previously documented in sheep and other small ruminants worldwide. Aim: Since there is a lack of research on

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Mahaney, Michael C., Carlo Brugnara, Loren R. Lease, and Orah S. Platt. "Genetic influences on peripheral blood cell counts: a study in baboons." Blood 106, no. 4 (2005): 1210–14. http://dx.doi.org/10.1182/blood-2004-12-4863.

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AbstractInterperson differences in peripheral blood cell counts in healthy individuals result from genetic and environmental influences. We used multivariate genetic analyses to assess the relative impact of genes and environment on baseline blood cell counts and indices using a pedigreed colony of baboons, an animal with well-documented analogies to human blood physiology. After accounting for age, sex, and weight, we found that genetic influences explain a significant proportion of the remaining variability, ranging from a low of 13.7% for mean corpuscular hemoglobin concentration (MCHC) to

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Hall, Philip D., Sally E. Self, and Rayna Kneuper Hall. "The Interaction of Maintenance Interferon with Cytolytic Cells in Patients with Multiple Myeloma Who Responded to Cytotoxic Chemotherapy." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 17, no. 2 (1997): 248–55. http://dx.doi.org/10.1002/j.1875-9114.1997.tb03706.x.

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Study Objective. To determine the long‐term effects of maintenance interferon on CD56+ and CD3+ cell activity.Design. Prospective phase II trial.Setting. Tertiary medical center and level 2 Veterans Administration hospital.Patients. Seven patients (age 45–74 yrs) with multiple myeloma who had reached the plateau phase from cytotoxic chemotherapy, and seven age‐ and sex‐matched controls.Interventions. All patients were given interferon‐α2b 3 × 106 U/m2 3 times/week.Measurements and Main Results. The CD56+, CD3+, and CD16+ counts were determined by flow cytometry in both peripheral blood and bon

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Abi Rached, Noor Mary, David R. Archer, Jayre A. Jones, Morgan Sterling, and Hyacinth I. Hyacinth. "Contribution of Vascular Cell Adhesion Molecule to Hemodynamics in Sickle Cell Disease." Blood 138, Supplement 1 (2021): 958. http://dx.doi.org/10.1182/blood-2021-153963.

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Abstract Vaso-occlusive events (VOEs) and pain crises are common clinical features of sickle cell disease (SCD) that result from sickle-shaped erythrocytes and leukocytes blocking blood flow, particularly in small vessels (Kato 2018). Activated endothelium also plays a role in the pathogenesis of VOEs in SCD. For example, VCAM-1 is expressed on blood vessels after activation by chemical and/or mechanical stimulation, which results in cytokine release. Studies have shown that patients with SCD have higher steady-state serum levels of soluble VCAM-1 compared to controls and that these levels are

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de Souza, Wanderley, Tecia Maria Ulisses de Carvalho, and Emile Santos Barrias. "Review onTrypanosoma cruzi: Host Cell Interaction." International Journal of Cell Biology 2010 (2010): 1–18. http://dx.doi.org/10.1155/2010/295394.

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Trypanosoma cruzi, the causative agent of Chagas' disease, which affects a large number of individuals in Central and South America, is transmitted to vertebrate hosts by blood-sucking insects. This protozoan is an obligate intracellular parasite. The infective forms of the parasite are metacyclic and bloodstream trypomastigote and amastigote. Metacyclic trypomastigotes are released with the feces of the insect while amastigotes and bloodstream trypomastigotes are released from the infected host cells of the vertebrate host after a complex intracellular life cycle. The recognition between para

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Pande, Priyanka, SreeNavya Inupala, Sowmya Jagana, Md Rasel Uzzaman, and Mulumebet Worku. "PSIV-28 Evaluation of Possible Interactions Between Platelets and Neutrophil in Cow Blood." Journal of Animal Science 101, Supplement_3 (2023): 358–59. http://dx.doi.org/10.1093/jas/skad281.424.

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Abstract Neutrophils have a central role in the inflammatory response and fight infection. Platelets are essential for hemostasis and thrombosis and fighting vascular damage. Studies in man show that the interaction between these cells can modulate their function. We aimed to assess the effect of possible relationships between the platelet count in whole blood on neutrophil activation. Blood samples (50 mL) from five clinically healthy Holstein Friesian cows at the NC A&T Dairy research unit were collected. Differential white blood cell counts were conducted using a VetScan (Zoetis). Neutr

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Clement, Oluwafemi Osowe, Olanrewaju Ademidun, Adesanya Adu Olufemi, David Oloruntola Olugbenga, and Adinma Chineke Clifford. "Performance, haematological and serum indices of broiler chicken fed fig leaf powder and vitamin c supplemented diets." World Journal of Advanced Research and Reviews 17, no. 3 (2023): 898–906. https://doi.org/10.5281/zenodo.8136035.

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Performance, haematological and serum chemistry of two broiler chicken breeds fed <em>Ficus carica</em> leaf powder and vitamin C supplemented diets were evaluated. Four hundred and eighty day-old broiler chicks (240 Arbor Acre and 240 Cobb 500) were allotted to eight treatments: diets 1 and 2 had no supplementation and fed to Arbor Acre and Cobb 500, respectively; diets 3 and 4 were supplemented with 200mg/kg vitamin C and fed to Arbor Acre and Cobb 500, respectively; diets 5 and 6 were supplemented with 1% <em>Ficus carica</em> leaf powder and fed to Arbor Acre and Cobb 5

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Fiala, Mark A., Tanya M. Wildes, Mark A. Schroeder, Armin Ghobadi, Keith E. Stockerl-Goldstein, and Ravi Vij. "Disparities in Healthcare Resource Utilization for Multiple Myeloma." Blood 132, Supplement 1 (2018): 4793. http://dx.doi.org/10.1182/blood-2018-99-118392.

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Abstract Background: Nearly half of older African-Americans who develop multiple myeloma (MM) do not receive systemic treatment. Those who do are less likely to receive newer treatments, such as novel agents and stem cell transplant, than their peers. In this study, we sought to determine if disparities in resource utilization exist even among patients receiving similar treatment. Methods: All newly diagnosed MM cases from 2007-2013 in the SEER-Medicare dataset were reviewed along with their corresponding claims data through 2014. We excluded cases 1) not enrolled in Medicare Part A, B, and D;

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Brittain, Julia E., Shantres C. Clark, Kenneth I. Ataga, Eugene P. Orringer та Leslie V. Parise. "Aggregates of Reticulocytes, Monocytes and Platelets Exist in Whole Blood of Sickle Cell Patients: Roles for Plasma Fibronectin, α4 Integrins and PSGL-1." Blood 106, № 11 (2005): 2330. http://dx.doi.org/10.1182/blood.v106.11.2330.2330.

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Abstract Leukocyte and platelets are understudied contributors to the overall pathology of sickle cell disease (SCD). Elevated leukocyte counts are common in these patients and correlate inversely with patient lifespan and overall disease severity. For example, a drop in neutrophil count typically predicts a patient’s response to hydroxyurea, while increased monocyte counts correlate directly with increased reporting of pain crises. Moreover, both RBCs and WBCs have been detected as components in vaso-occlusive blockages in mouse models, where adhesive RBCs appear to interact directly with WBC

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Albelda, S. M., P. D. Oliver, L. H. Romer, and C. A. Buck. "EndoCAM: a novel endothelial cell-cell adhesion molecule." Journal of Cell Biology 110, no. 4 (1990): 1227–37. http://dx.doi.org/10.1083/jcb.110.4.1227.

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Cell-cell adhesion is controlled by many molecules found on the cell surface. In addition to the constituents of well-defined junctional structures, there are the molecules that are thought to play a role in the initial interactions of cells and that appear at precise times during development. These include the cadherins and cell adhesion molecules (CAMs). Representatives of these families of adhesion molecules have been isolated from most of the major tissues. The notable exception is the vascular endothelium. Here we report the identification of a cell surface molecule designated "endoCAM" (

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Jansa, Rado, Roman Stukelj, Vid Sustar, Apolonija Bedina Zavec, Borut Stabuc, and Veronika Kralj Iglic. "Blood cell-derived nanovesicles as biomarkers of homeostasis in gastrointestinal cancer." Journal of Clinical Oncology 31, no. 4_suppl (2013): 152. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.152.

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152 Background: Nanovesicles (NVs) are membrane-enclosed fragments of cell interior which are pinched off from membranes of cells of all types (including cancer) in the last stage of the budding process. They are involved in cell-cell communication and can promote tumor growth and invasion. Interactions of tumor-derived NVs with blood cells, especially platelets are hypothetically reflected in vesiculability of platelets by means of concentration of NVs in blood isolates. Also we hypothesized that in patients whose plasma mediates stronger attractive interaction between membranes the concentra

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Armes, Wyatt D., Clothilde Villot, Eric Chevaux, et al. "PSVIII-2 Effects of post-ruminal yeast cell wall extract on dry matter intake, gastrointestinal fermentation and permeability, and concentrations of white blood cell types in beef heifers exposed to feed restriction." Journal of Animal Science 102, Supplement_3 (2024): 585–86. http://dx.doi.org/10.1093/jas/skae234.658.

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Abstract The objective of this study was to evaluate whether post-ruminal provision of a yeast cell wall extract (YCW) affected gastrointestinal fermentation characteristics and permeability, and white blood cell concentrations for heifers exposed to feed restriction (FR). Ruminally cannulated beef heifers (n = 8) were used in a 2 × 2 crossover design. Treatments (TRT) included an abomasal infusion of a placebo (PLC; maltodextrin) or YCW derived from Saccharomyces cerevisiae (2 g/dose) infused at 0600 and 1800 h. Heifers were subject to a 5-d baseline period followed by 5 d of FR where dry mat

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Clement Oluwafemi Osowe, Ademidun Olanrewaju, Olufemi Adesanya Adu, Olugbenga David Oloruntola, and Clifford Adinma Chineke. "Performance, haematological and serum indices of broiler chicken fed fig leaf powder and vitamin c supplemented diets." World Journal of Advanced Research and Reviews 17, no. 3 (2023): 898–906. http://dx.doi.org/10.30574/wjarr.2023.17.3.0441.

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Performance, haematological and serum chemistry of two broiler chicken breeds fed Ficus carica leaf powder and vitamin C supplemented diets were evaluated. Four hundred and eighty day-old broiler chicks (240 Arbor Acre and 240 Cobb 500) were allotted to eight treatments: diets 1 and 2 had no supplementation and fed to Arbor Acre and Cobb 500, respectively; diets 3 and 4 were supplemented with 200mg/kg vitamin C and fed to Arbor Acre and Cobb 500, respectively; diets 5 and 6 were supplemented with 1% Ficus carica leaf powder and fed to Arbor Acre and Cobb 500; while diets 7 and 8 were supplemen

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Hashtjin, Yasaman Aghaei, Mahdieh Raeeszadeh, and Ali Parsa Khanghah. "Interaction of Heavy Metals (Cadmium and Selenium) in an Experimental Study on Goldfish: Hematobiochemical Changes and Oxidative Stress." Journal of Xenobiotics 15, no. 2 (2025): 57. https://doi.org/10.3390/jox15020057.

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Background: Heavy metal interactions within aquatic ecosystems significantly affect fish physiology. This study evaluated the protective role of selenium against cadmium-induced hematological, biochemical, and electrophoretic alterations in goldfish. Methods: A total of 120 goldfish individuals were divided into four groups: control, cadmium chloride-treated (2.8 mg/L), sodium selenite-treated (2 mg/L), and a combined cadmium and selenium-treated group. After 14 days, blood samples were collected and analyzed for hematological parameters, biochemical markers, and serum protein electrophoresis.

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Pugsley, Haley Renee, Sherree Friend, Christine Probst, and Phil Morrissey. "Identifying exosome binding and internalization in blood cell subsets by imaging flow cytometry." Journal of Immunology 196, no. 1_Supplement (2016): 197.14. http://dx.doi.org/10.4049/jimmunol.196.supp.197.14.

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Abstract Only recently has the importance of extracellular vesicles as key mediators of intercellular communication been appreciated. Extracellular vesicles are membrane derived structures that include exosomes, microvesicles and apoptotic bodies. Exosomes have been shown to transfer molecules between cells and have the potential to transfer signals between cells. Exosomes are released under normal physiological conditions; however, they are also believed to serve as mediators in the pathogenesis of neurological, vascular, hematological and autoimmune diseases as well as cancer. Quantifying an

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Ueda, Koki, Saori Miura, Tomofumi Misaka, et al. "Interaction between JAK2-Mutated Neutrophils and Platelets Initiates Thrombosis Via Neutrophil Extracellular Traps." Blood 142, Supplement 1 (2023): 740. http://dx.doi.org/10.1182/blood-2023-174584.

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Thrombosis is one of the most common complications of myeloproliferative neoplasms with JAK2-V617F mutation. Recently, individuals with clonal hematopoiesis (CH) harboring JAK2-V617F mutation were also shown to have 12-fold higher risk of thrombosis compared to JAK2 non-mutated individuals (N Engl J Med. 2017;377:111-121). The finding that individuals with JAK2-V617F CH do not have altered blood counts suggests the mechanisms other than increases in the hematopoietic cells which induce thrombosis associated with JAK2-V617F hematopoiesis. JAK2-V617F neutrophils are primed to neutrophil extracel

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Cerboni, Cristina, Alessandra Zingoni, Marco Cippitelli, Mario Piccoli, Luigi Frati, and Angela Santoni. "Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis." Blood 110, no. 2 (2007): 606–15. http://dx.doi.org/10.1182/blood-2006-10-052720.

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AbstractRecent evidence indicates that natural killer (NK) cells can negatively regulate T-cell responses, but the mechanisms behind this phenomenon as a consequence of NK–T-cell interactions are poorly understood. We studied the interaction between the NKG2D receptor and its ligands (NKG2DLs), and asked whether T cells expressed NKG2DLs in response to superantigen, alloantigen, or a specific antigenic peptide, and if this rendered them susceptible to NK lysis. As evaluated by FACS, the major histocompatibility complex (MHC) class I chain-related protein A (MICA) was the ligand expressed earli

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Ariens, Robert A. S. "Contribution of Red Blood Cells and Clot Structure to Thrombosis." Blood 126, no. 23 (2015): SCI—15—SCI—15. http://dx.doi.org/10.1182/blood.v126.23.sci-15.sci-15.

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Abstract The blood clot or thrombus is composed of red blood cells, platelets and white cells that interact with the fibrin meshwork produced by the coagulation system. The red blood cells form polyhedrocytes that seal the clot, platelets provide forces for clot contraction, and white cells contribute neutrophil extracellular traps, cytokines and complement activation. The fibrin network contributes clot elasticity and provides the proteinaceous backbone structure that stabilises the clot. Previous studies from our laboratory and others have shown that dense fibrin networks demonstrating small

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Grassinger, Jochen, David N. Haylock, Melonie J. Storan та ін. "Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with α9β1 and α4β1 integrins". Blood 114, № 1 (2009): 49–59. http://dx.doi.org/10.1182/blood-2009-01-197988.

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AbstractOsteopontin (OPN), a multifunctional acidic glycoprotein, expressed by osteoblasts within the endosteal region of the bone marrow (BM) suppresses the proliferation of hemopoietic stem and progenitor cells and also regulates their lodgment within the BM after transplantation. Herein we demonstrate that OPN cleavage fragments are the most abundant forms of this protein within the BM. Studies aimed to determine how hemopoietic stem cells (HSCs) interact with OPN revealed for the first time that murine and human HSCs express α9β1 integrin. The N-terminal thrombin cleavage fragment of OPN t

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Ferrao Blanco, Mauricio Nicolás, Bexultan Kazybay, Olaf Heidenreich, and Josef Vormoor. "Single-Cell Dissection of the B-ALL Niche Reveals Distinct Mesenchymal Stromal Cell Subtypes with Differential Leukemic Cell Support and Relapse Implications." Blood 144, Supplement 1 (2024): 1299. https://doi.org/10.1182/blood-2024-205911.

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Despite the advancements in treatment, relapse remains a major hurdle in B-cell acute lymphoblastic leukemia (B-ALL). The bone marrow microenvironment, particularly the stromal compartment, is implicated in B-ALL progression, yet its cellular heterogeneity and contribution to disease pathogenesis remain elusive. To elucidate these mechanisms, we employed single-cell RNA-sequencing to map the bone marrow landscape in B-ALL patients (n=9). Our analysis revealed 11 distinct cell populations, including leukemic cells, mesenchymal stromal cells (MSCs), and immune cell subsets. In-depth analysis of

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Jiang, Qianli, Yan-yan Ye, Le-zhong Yuan, et al. "Study Of Stem Cell Homing and Donor-Recipient Cellular Interaction In Allogenic Hematopoietic Stem Cell Transplantation Mice Model." Blood 122, no. 21 (2013): 5424. http://dx.doi.org/10.1182/blood.v122.21.5424.5424.

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Abstract Background Allogeneic hematopoietic stem cell transplantation is an effective method for treatment of hematological malignancies, while GVHD and graft rejection are main complications, which seriously affect patients' survival rates and quality of life. Aim Establishing allo-transplantation mice model with mRFP and GFP transgenic mice, to simulate clinical hematopoietic stem cell transplantation and explore the mechanism of stem cell homing and GVHD. Methods 1) Thirteen C57BL/6 GFP transgenic mice, used as recipients, were irradiated with 7 Gy. Each mouse was injected through caudal v

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