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Journal articles on the topic 'Whole-brain map'

Author: Grafiati

Published: 10 March 2023

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1

Brittin, Christopher A., Steven J. Cook, David H. Hall, Scott W. Emmons, and Netta Cohen. "A multi-scale brain map derived from whole-brain volumetric reconstructions." Nature 591, no. 7848 (2021): 105–10. http://dx.doi.org/10.1038/s41586-021-03284-x.

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Lee, Dongha, and Hae-Jeong Park. "A populational connection map for the whole brain white matter." IBRO Reports 6 (September 2019): S153. http://dx.doi.org/10.1016/j.ibror.2019.07.486.

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3

Bernat, James L. "THE BIOPHILOSOPHICAL BASIS OF WHOLE-BRAIN DEATH." Social Philosophy and Policy 19, no. 2 (2002): 324–42. http://dx.doi.org/10.1017/s0265052502192132.

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Notwithstanding these wise pronouncements, my project here is to characterize the biological phenomenon of death of the higher animal species, such as vertebrates. My claim is that the formulation of “whole-brain death” provides the most congruent map for our correct understanding of the concept of death. This essay builds upon the foundation my colleagues and I have laid since 1981 to characterize the concept of death and refine when this event occurs. Although our society's well-accepted program of multiple organ procurement for transplantation requires the organ donor first to be dead, the

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Shi, Yuhang, S. Johanna Vannesjo, Karla L. Miller, and Stuart Clare. "Template-based field map prediction for rapid whole brain B0 shimming." Magnetic Resonance in Medicine 80, no. 1 (2017): 171–80. http://dx.doi.org/10.1002/mrm.27020.

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Jung, Youjin, Raymond P. Viviano, Sanneke van Rooden, Jeroen van der Grond, Serge A. R. B. Rombouts, and Jessica S. Damoiseaux. "White Matter Hyperintensities and Apolipoprotein E Affect the Association Between Mean Arterial Pressure and Objective and Subjective Cognitive Functioning in Older Adults." Journal of Alzheimer's Disease 84, no. 3 (2021): 1337–50. http://dx.doi.org/10.3233/jad-210695.

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Background: White matter hyperintensities (WMH) show a robust relationship with arterial pressure as well as objective and subjective cognitive functioning. In addition, APOE ɛ4 carriership may influence how arterial pressure affects cognitive functioning. Objective: To determine the role of region-specific WMH burden and APOE ɛ4 carriership on the relationship between mean arterial pressure (MAP) and cognitive function as well as subjective cognitive decline (SCD). Methods: The sample consisted of 87 cognitively unimpaired middle-aged to older adults aged 50–85. We measured WMH volume for the

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Morone, Flaviano, Kevin Roth, Byungjoon Min, H. Eugene Stanley, and Hernán A. Makse. "Model of brain activation predicts the neural collective influence map of the brain." Proceedings of the National Academy of Sciences 114, no. 15 (2017): 3849–54. http://dx.doi.org/10.1073/pnas.1620808114.

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Efficient complex systems have a modular structure, but modularity does not guarantee robustness, because efficiency also requires an ingenious interplay of the interacting modular components. The human brain is the elemental paradigm of an efficient robust modular system interconnected as a network of networks (NoN). Understanding the emergence of robustness in such modular architectures from the interconnections of its parts is a longstanding challenge that has concerned many scientists. Current models of dependencies in NoN inspired by the power grid express interactions among modules with

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Deleo, Francesco, Seok-Jun Hong, Fatemeh Fadaie, et al. "Whole-brain multimodal MRI phenotyping of periventricular nodular heterotopia." Neurology 95, no. 17 (2020): e2418-e2426. http://dx.doi.org/10.1212/wnl.0000000000010648.

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ObjectiveTo test the hypothesis that in periventricular nodular heterotopia (PVNH) structure and function of cortical areas overlying the heterotopic gray matter are preferentially affected.MethodsWe studied a group of 40 patients with PVNH and normal-appearing cortex and compared their quantitative MRI markers of brain development, structure, and function to those of 43 age- and sex-matched healthy controls. Inspired by models of neocortical development suggesting that neuronal migration follows a curvilinear path to preserve topologic correspondence between the outer ventricular zone and the

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Tao, Jingshan, Yong Cai, Yisheng Dai, Yingdi Xie, Hailing Liu, and Xiaojin Zang. "Value of 4D CT Angiography Combined with Whole Brain CT Perfusion Imaging Feature Analysis under Deep Learning in Imaging Examination of Acute Ischemic Stroke." Computational Intelligence and Neuroscience 2022 (June 13, 2022): 1–9. http://dx.doi.org/10.1155/2022/2286413.

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This study was aimed at investigating the application of deep learning 4D computed tomography angiography (CTA) combined with whole brain CT perfusion (CTP) imaging in acute ischemic stroke (AIS). A total of 46 patients with ischemic stroke were selected from the hospital as the research objects. Image quality was analyzed after the 4D CTA images were obtained by perfusion imaging. The results showed that whole brain perfusion imaging based on FCN can achieve automatic segmentation. FCN segmentation results took a short time, an average of 2-3 seconds, and the Dice similarity coefficient (DSC)

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Jehl, Markus, Ekaterina Mikhaylova, Valerie Treyer, et al. "Attenuation Correction Using Template PET Registration for Brain PET: A Proof-of-Concept Study." Journal of Imaging 9, no. 1 (2022): 2. http://dx.doi.org/10.3390/jimaging9010002.

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NeuroLF is a dedicated brain PET system with an octagonal prism shape housed in a scanner head that can be positioned around a patient’s head. Because it does not have MR or CT capabilities, attenuation correction based on an estimation of the attenuation map is a crucial feature. In this article, we demonstrate this method on [18F]FDG PET brain scans performed with a low-resolution proof of concept prototype of NeuroLF called BPET. We perform an affine registration of a template PET scan to the uncorrected emission image, and then apply the resulting transform to the corresponding template at

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Yang, Hsiao T., and Kevin J. Cummings. "Brain stem serotonin protects blood pressure in neonatal rats exposed to episodic anoxia." Journal of Applied Physiology 115, no. 12 (2013): 1733–41. http://dx.doi.org/10.1152/japplphysiol.00970.2013.

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In neonatal rodents, a loss of brain stem serotonin [5-hydroxytryptamine (5-HT)] in utero or at birth compromises anoxia-induced gasping and the recovery of heart rate (HR) and breathing with reoxygenation (i.e., autoresuscitation). How mean arterial pressure (MAP) is influenced after an acute loss of brain stem 5-HT content is unknown. We hypothesized that a loss of 5-HT for ∼1 day would compromise MAP during episodic anoxia. We injected 6-fluorotryptophan (20 mg/kg ip) into rat pups (postnatal days 9–10 or 11–13, n = 22 treated, 24 control), causing a ∼70% loss of brain stem 5-HT. Pups were

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Nadig, Ajay, Jakob Seidlitz, Cassidy L. McDermott, et al. "Morphological integration of the human brain across adolescence and adulthood." Proceedings of the National Academy of Sciences 118, no. 14 (2021): e2023860118. http://dx.doi.org/10.1073/pnas.2023860118.

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Brain structural covariance norms capture the coordination of neurodevelopmental programs between different brain regions. We develop and apply anatomical imbalance mapping (AIM), a method to measure and model individual deviations from these norms, to provide a lifespan map of morphological integration in the human cortex. In cross-sectional and longitudinal data, analysis of whole-brain average anatomical imbalance reveals a reproducible tightening of structural covariance by age 25 y, which loosens after the seventh decade of life. Anatomical imbalance change in development and in aging is

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Wild, J. M., H. Reinke, and S. M. Farabaugh. "A non-thalamic pathway contributes to a whole body map in the brain of the budgerigar." Brain Research 755, no. 1 (1997): 137–41. http://dx.doi.org/10.1016/s0006-8993(97)00026-7.

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Kaboodvand, Neda, Martijn P. van den Heuvel, and Peter Fransson. "Adaptive frequency-based modeling of whole-brain oscillations: Predicting regional vulnerability and hazardousness rates." Network Neuroscience 3, no. 4 (2019): 1094–120. http://dx.doi.org/10.1162/netn_a_00104.

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Whole-brain computational modeling based on structural connectivity has shown great promise in successfully simulating fMRI BOLD signals with temporal coactivation patterns that are highly similar to empirical functional connectivity patterns during resting state. Importantly, previous studies have shown that spontaneous fluctuations in coactivation patterns of distributed brain regions have an inherent dynamic nature with regard to the frequency spectrum of intrinsic brain oscillations. In this modeling study, we introduced frequency dynamics into a system of coupled oscillators, where each o

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Li, Xiangning, Bin Yu, Qingtao Sun, et al. "Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons." Proceedings of the National Academy of Sciences 115, no. 2 (2017): 415–20. http://dx.doi.org/10.1073/pnas.1703601115.

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The cholinergic system in the brain plays crucial roles in regulating sensory and motor functions as well as cognitive behaviors by modulating neuronal activity. Understanding the organization of the cholinergic system requires a complete map of cholinergic neurons and their axon arborizations throughout the entire brain at the level of single neurons. Here, we report a comprehensive whole-brain atlas of the cholinergic system originating from various cortical and subcortical regions of the mouse brain. Using genetically labeled cholinergic neurons together with whole-brain reconstruction of o

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Ruggieri, Serena, Fulvia Fanelli, Letizia Castelli, Nikolaos Petsas, Laura De Giglio, and Luca Prosperini. "Lesion symptom map of cognitive–postural interference in multiple sclerosis." Multiple Sclerosis Journal 24, no. 5 (2017): 653–62. http://dx.doi.org/10.1177/1352458517701313.

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Objective: To investigate the disease-altered structure–function relationship underlying the cognitive–postural interference (CPI) phenomenon in multiple sclerosis (MS). Methods: We measured postural sway of 96 patients and 48 sex-/age-matched healthy controls by force platform in quiet standing (single-task (ST)) while performing the Stroop test (dual-task (DT)) to estimate the dual-task cost (DTC) of balance. In patient group, binary T2 and T1 lesion masks and their corresponding lesion volumes were obtained from magnetic resonance imaging (MRI) of brain. Normalized brain volume (NBV) was al

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Kirstein, Marina, and Rolien Kunz. "A Whole Brain® learning approach to an undergraduate auditing initiative – an exploratory study." Meditari Accountancy Research 24, no. 4 (2016): 527–44. http://dx.doi.org/10.1108/medar-02-2014-0029.

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Purpose Individual students have different learning styles, and lecturers can no longer afford to ignore this. Lecturers have a responsibility to accommodate students’ different learning styles by including learning style flexibility in the offered learning opportunities. The purpose of this study is to map a teaching case study against the Herrmann Whole Brain® model to determine whether learning style flexibility has been incorporated in the teaching case study. Design/methodology/approach A teaching case study was developed and delivered as part of an undergraduate level course at a South A

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Fu, Jia-Yu, Xiao-Dan Yu, Yi Zhu, et al. "Whole-Brain Map of Long-Range Monosynaptic Inputs to Different Cell Types in the Amygdala of the Mouse." Neuroscience Bulletin 36, no. 11 (2020): 1381–94. http://dx.doi.org/10.1007/s12264-020-00545-z.

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AbstractThe amygdala, which is involved in various behaviors and emotions, is reported to connect with the whole brain. However, the long-range inputs of distinct cell types have not yet been defined. Here, we used a retrograde trans-synaptic rabies virus to generate a whole-brain map of inputs to the main cell types in the mouse amygdala. We identified 37 individual regions that projected to neurons expressing vesicular glutamate transporter 2, 78 regions to parvalbumin-expressing neurons, 104 regions to neurons expressing protein kinase C-δ, and 89 regions to somatostatin-expressing neurons.

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Sun, Qingtao, Xiangning Li, Miao Ren, et al. "A whole-brain map of long-range inputs to GABAergic interneurons in the mouse medial prefrontal cortex." Nature Neuroscience 22, no. 8 (2019): 1357–70. http://dx.doi.org/10.1038/s41593-019-0429-9.

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Duan, Zhuonan, Anan Li, Hui Gong, and Xiangning Li. "A Whole-brain Map of Long-range Inputs to GABAergic Interneurons in the Mouse Caudal Forelimb Area." Neuroscience Bulletin 36, no. 5 (2020): 493–505. http://dx.doi.org/10.1007/s12264-019-00458-6.

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Jonas, Jacques, Corentin Jacques, Joan Liu-Shuang, et al. "A face-selective ventral occipito-temporal map of the human brain with intracerebral potentials." Proceedings of the National Academy of Sciences 113, no. 28 (2016): E4088—E4097. http://dx.doi.org/10.1073/pnas.1522033113.

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Human neuroimaging studies have identified a network of distinct face-selective regions in the ventral occipito-temporal cortex (VOTC), with a right hemispheric dominance. To date, there is no evidence for this hemispheric and regional specialization with direct measures of brain activity. To address this gap in knowledge, we recorded local neurophysiological activity from 1,678 contact electrodes implanted in the VOTC of a large group of epileptic patients (n = 28). They were presented with natural images of objects at a rapid fixed rate (six images per second: 6 Hz), with faces interleaved a

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Buchsbaum, Bradley R., Sabrina Lemire-Rodger, Candice Fang, and Hervé Abdi. "The Neural Basis of Vivid Memory Is Patterned on Perception." Journal of Cognitive Neuroscience 24, no. 9 (2012): 1867–83. http://dx.doi.org/10.1162/jocn_a_00253.

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When we have a rich and vivid memory for a past experience, it often feels like we are transported back in time to witness once again this event. Indeed, a perfect memory would exactly mimic the experiential quality of direct sensory perception. We used fMRI and multivoxel pattern analysis to map and quantify the similarity between patterns of activation evoked by direct perception of a diverse set of short video clips and the vivid remembering, with closed eyes, of these clips. We found that the patterns of distributed brain activation during vivid memory mimicked the patterns evoked during s

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Norris, Scott A., Aimee E. Morris, Meghan C. Campbell, et al. "Regional, not global, functional connectivity contributes to isolated focal dystonia." Neurology 95, no. 16 (2020): e2246-e2258. http://dx.doi.org/10.1212/wnl.0000000000010791.

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ObjectiveTo test the hypothesis that there is shared regional or global functional connectivity dysfunction in a large cohort of patients with isolated focal dystonia affecting different body regions compared to control participants. In this case-control study, we obtained resting-state MRI scans (three or four 7.3-minute runs) with eyes closed in participants with focal dystonia (cranial [17], cervical [13], laryngeal [18], or limb [10]) and age- and sex-matched controls.MethodsRigorous preprocessing for all analyses was performed to minimize effect of head motion during scan acquisition (dys

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Ogoh, Shigehiko, Mads K. Dalsgaard, Chie C. Yoshiga, et al. "Dynamic cerebral autoregulation during exhaustive exercise in humans." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 3 (2005): H1461—H1467. http://dx.doi.org/10.1152/ajpheart.00948.2004.

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We investigated whether dynamic cerebral autoregulation is affected by exhaustive exercise using transfer-function gain and phase shift between oscillations in mean arterial pressure (MAP) and middle cerebral artery (MCA) mean blood flow velocity ( Vmean). Seven subjects were instrumented with a brachial artery catheter for measurement of MAP and determination of arterial Pco2 (PaCO2) while jugular venous oxygen saturation (SvO2) was determined to assess changes in whole brain blood flow. After a 10-min resting period, the subjects performed dynamic leg-cycle ergometry at 168 ± 5 W (mean ± SE)

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Liu, Sa, Jun Nie, Yusha Li, Tingting Yu, Dan Zhu, and Peng Fei. "Three-dimensional, isotropic imaging of mouse brain using multi-view deconvolution light sheet microscopy." Journal of Innovative Optical Health Sciences 10, no. 05 (2017): 1743006. http://dx.doi.org/10.1142/s1793545817430064.

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We present a three-dimensional (3D) isotropic imaging of mouse brain using light-sheet fluorescent microscopy (LSFM) in conjunction with a multi-view imaging computation. Unlike common single view LSFM is used for mouse brain imaging, the brain tissue is 3D imaged under eight views in our study, by a home-built selective plane illumination microscopy (SPIM). An output image containing complete structural information as well as significantly improved resolution ([Formula: see text]4 times) are then computed based on these eight views of data, using a bead-guided multi-view registration and deco

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Hashemi, Meysam, Anirudh N. Vattikonda, Viktor Sip, et al. "On the influence of prior information evaluated by fully Bayesian criteria in a personalized whole-brain model of epilepsy spread." PLOS Computational Biology 17, no. 7 (2021): e1009129. http://dx.doi.org/10.1371/journal.pcbi.1009129.

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Individualized anatomical information has been used as prior knowledge in Bayesian inference paradigms of whole-brain network models. However, the actual sensitivity to such personalized information in priors is still unknown. In this study, we introduce the use of fully Bayesian information criteria and leave-one-out cross-validation technique on the subject-specific information to assess different epileptogenicity hypotheses regarding the location of pathological brain areas based on a priori knowledge from dynamical system properties. The Bayesian Virtual Epileptic Patient (BVEP) model, whi

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Shi, Zilun, Chris Dawson, Stephen L. W. On, and Malik Altaf Hussain. "Partial Proteome Map of Campylobacter Jejuni Strain Nctc11168 by Gel-Free Proteomics Analysis." International Journal of Applied Sciences and Biotechnology 2, no. 4 (2014): 464–77. http://dx.doi.org/10.3126/ijasbt.v2i4.11253.

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A proteome map of the foodborne pathogen Campylobacter jejuni NCTC11168 was analyzed using a state-of-the-art gel-free proteomic approach for the first time. A whole cell protein extract was prepared from the C. jejuni strain NCTC11168 grown in brain heart infusion (BHI) broth at 42°C under microaerobic conditions. A gel-free technique using isobaric tags for relative and absolute quantitation (iTRAQ) was employed to create a protein expression profile of the strain. Liquid chromatography-mass spectrometry (LC-MS/MS) was used to identify the proteins. Protein functionalities were searched to c

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Ustinin, M. N., S. D. Rykunov, A. I. Boyko, and O. A. Maslova. "Reconstruction of the Human Brain Functional Structure Based on the Electroencephalography Data." Mathematical Biology and Bioinformatics 15, no. 1 (2020): 106–17. http://dx.doi.org/10.17537/2020.15.106.

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New method for the data analysis was proposed, making it possible to transform multichannel time series into the spatial structure of the system under study. The method was successfully used to investigate biological and physical objects based on the magnetic field measurements. In this paper we further develop this method to analyze the data of the experiments where the electric field is measured. The brain activity in the state of subject “eyes closed” was registered by the 19-channel electric encephalograph, using the 10-20 scheme. The electroencephalograms were obtained in resting state an

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Gatica, Marilyn, Fernando E. Rosas, Pedro A. M. Mediano, et al. "High-order functional redundancy in ageing explained via alterations in the connectome in a whole-brain model." PLOS Computational Biology 18, no. 9 (2022): e1010431. http://dx.doi.org/10.1371/journal.pcbi.1010431.

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The human brain generates a rich repertoire of spatio-temporal activity patterns, which support a wide variety of motor and cognitive functions. These patterns of activity change with age in a multi-factorial manner. One of these factors is the variations in the brain’s connectomics that occurs along the lifespan. However, the precise relationship between high-order functional interactions and connnectomics, as well as their variations with age are largely unknown, in part due to the absence of mechanistic models that can efficiently map brain connnectomics to functional connectivity in aging.

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Fields, Melanie E., Kristin P. Guilliams, Dustin K. Ragan, et al. "Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease." Neurology 90, no. 13 (2018): e1134-e1142. http://dx.doi.org/10.1212/wnl.0000000000005194.

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ObjectiveTo determine mechanisms underlying regional vulnerability to infarction in sickle cell disease (SCD) by measuring voxel-wise cerebral blood flow (CBF), oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen utilization (CMRO2) in children with SCD.MethodsParticipants underwent brain MRIs to measure voxel-based CBF, OEF, and CMRO2. An infarct heat map was created from an independent pediatric SCD cohort with silent infarcts and compared to prospectively obtained OEF maps.ResultsFifty-six participants, 36 children with SCD and 20 controls, completed the study evaluation

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Fields, Melanie E., Kristin P. Guilliams, Dustin Ragan, et al. "Elevations in MR Measurements of Whole Brain and Regional Cerebral Blood Flow and Oxygen Extraction Fraction Suggest Cerebral Metabolic Stress in Children with Sickle Cell Disease Unaffected By Overt Stroke." Blood 126, no. 23 (2015): 69. http://dx.doi.org/10.1182/blood.v126.23.69.69.

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Abstract Positron emission tomography (PET) studies have shown that the brain increases cerebral blood flow (CBF) and oxygen extraction fraction (OEF, the fraction of oxygen brain tissue extracts from blood) when oxygen delivery is compromised in adult ischemic stroke. Children with sickle cell disease (SCD) have higher CBF compared to healthy children, suggesting that autoregulatory mechanisms, compensating for compromised oxygen delivery, may underlie the pathophysiology of ischemic stroke in SCD. Until now, evaluation of cerebral oxygen metabolism in children with SCD has been limited to me

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Liu, Bin, Yuan Feng, Ming Yang, et al. "Functional Connectivity in Patients With Sensorineural Hearing Loss Using Resting-State MRI." American Journal of Audiology 24, no. 2 (2015): 145–52. http://dx.doi.org/10.1044/2015_aja-13-0068.

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Purpose This study was undertaken to evaluate whole-brain functional connectivity changes related to auditory cortex in patients with left-sided sensorineural hearing loss (SNHL) using resting-state functional connectivity magnetic resonance imaging. Method Imaging was performed in 19 patients with left-sided SNHL and 35 individuals in the control group without SNHL. Data were collected and analyzed to map functional connectivity using the left/right primary auditory cortex as the region of interest to identify global differences between patients with SNHL and the control group. Results In com

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Favre, Hugues, Mathieu Pernot, Mickael Tanter, and Clément Papadacci. "Boosting transducer matrix sensitivity for 3D large field ultrasound localization microscopy using a multi-lens diffracting layer: a simulation study." Physics in Medicine & Biology 67, no. 8 (2022): 085009. http://dx.doi.org/10.1088/1361-6560/ac5f72.

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Abstract Mapping blood microflows of the whole brain is crucial for early diagnosis of cerebral diseases. Ultrasound localization microscopy (ULM) was recently applied to map and quantify blood microflows in 2D in the brain of adult patients down to the micron scale. Whole brain 3D clinical ULM remains challenging due to the transcranial energy loss which significantly reduces the imaging sensitivity. Large aperture probes with a large surface can increase both resolution and sensitivity. However, a large active surface implies thousands of acoustic elements, with limited clinical translation.

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Lee, Dongha, and Hae-Jeong Park. "A populational connection distribution map for the whole brain white matter reveals ordered cortical wiring in the space of white matter." NeuroImage 254 (July 2022): 119167. http://dx.doi.org/10.1016/j.neuroimage.2022.119167.

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Baracho, Nilo César do Vale, Guilherme Pedrosa Guizelli, Beatriz Leone Carmello, et al. "Cardiovascular and hematologic effects produced by chronic treatment with etoricoxib in normotensive rats." Acta Cirurgica Brasileira 24, no. 3 (2009): 206–10. http://dx.doi.org/10.1590/s0102-86502009000300008.

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PURPOSE: Evaluate the cardiovascular and hematological effects produced by chronic treatment with two dosis of etoricoxib in Wistar normotensive rats. METHODS: Thirty rats have been used and divided into one control group and two etoricoxib (10mg/kg and 30mg/kg) treatments groups for 60 days. The mean arterial pressure (MAP) was taken during the whole experimental period and at the end of this period, under anesthesia blood samples were taken, and further the withdrawn of the aorta, heart, brain, liver, and kidneys for the anatomopathologic study. RESULTS: The treatment with etoricoxib (30mg/K

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Hiroki, Masahiko, Naofumi Kajimura, Takeshi Uema, et al. "Effect of Benzodiazepine Hypnotic Triazolam on Relationship of Blood Pressure and Paco2 to Cerebral Blood Flow During Human Non-Rapid Eye Movement Sleep." Journal of Neurophysiology 95, no. 4 (2006): 2293–303. http://dx.doi.org/10.1152/jn.00114.2005.

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We sought to clarify the effect of short-acting benzodiazepine hypnotic on the relationship of arterial blood pressure and arterial partial pressure of carbon dioxide (Paco2) to regional cerebral blood flow (rCBF) during human non-rapid-eye-movement (non-REM) sleep. Nine young normal volunteers were treated in a randomized, crossover design with triazolam or placebo and underwent positron emission tomography at night. During wakefulness and stage 2 and slow wave (stages 3 and 4) sleep, we measured mean arterial blood pressure (MAP), Paco2, and absolute CBF. With triazolam compared to placebo,

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Zhang, Weiguo, Bing S. Huang, and Frans H. H. Leenen. "Brain renin-angiotensin system and sympathetic hyperactivity in rats after myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 276, no. 5 (1999): H1608—H1615. http://dx.doi.org/10.1152/ajpheart.1999.276.5.h1608.

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Blockade of brain “ouabain” prevents the sympathetic hyperactivity and impairment of baroreflex function in rats with congestive heart failure (CHF). Because brain “ouabain” may act by activating the brain renin-angiotensin system (RAS), the aim of the present study was to assess whether chronic treatment with the AT1-receptor blocker losartan given centrally normalizes the sympathetic hyperactivity and impairment of baroreflex function in Wistar rats with CHF postmyocardial infarction (MI). After left coronary artery ligation (2 or 6 wk), rats received either intracerebroventricular losartan

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Englund, Erin K., Maria A. Fernández-Seara, Ana E. Rodríguez-Soto, et al. "Calibrated fMRI for dynamic mapping of CMRO2 responses using MR-based measurements of whole-brain venous oxygen saturation." Journal of Cerebral Blood Flow & Metabolism 40, no. 7 (2019): 1501–16. http://dx.doi.org/10.1177/0271678x19867276.

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Functional MRI (fMRI) can identify active foci in response to stimuli through BOLD signal fluctuations, which represent a complex interplay between blood flow and cerebral metabolic rate of oxygen (CMRO2) changes. Calibrated fMRI can disentangle the underlying contributions, allowing quantification of the CMRO2 response. Here, whole-brain venous oxygen saturation ( Y v) was computed alongside ASL-measured CBF and BOLD-weighted data to derive the calibration constant, M, using the proposed Y v-based calibration. Data were collected from 10 subjects at 3T with a three-part interleaved sequence c

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De-Giorgio, Fabio, Gabriele Ciasca, Gennaro Fecondo, et al. "Post mortem computed tomography meets radiomics: a case series on fractal analysis of post mortem changes in the brain." International Journal of Legal Medicine 136, no. 3 (2022): 719–27. http://dx.doi.org/10.1007/s00414-022-02801-5.

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AbstractEstimating the post-mortem interval is a fundamental, albeit challenging task in forensic sciences. To this aim, forensic practitioners need to assess post-mortem changes through a plethora of different methods, most of which are inherently qualitative, thus providing broad time intervals rather than precise determinations. This challenging problem is further complicated by the influence of environmental factors, which modify the temporal dynamics of post-mortem changes, sometimes in a rather unpredictable fashion. In this context, the search for quantitative and objective descriptors

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Bueichekú, Elisenda, Maite Aznárez-Sanado, Ibai Diez, et al. "Central neurogenetic signatures of the visuomotor integration system." Proceedings of the National Academy of Sciences 117, no. 12 (2020): 6836–43. http://dx.doi.org/10.1073/pnas.1912429117.

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Visuomotor impairments characterize numerous neurological disorders and neurogenetic syndromes, such as autism spectrum disorder (ASD) and Dravet, Fragile X, Prader–Willi, Turner, and Williams syndromes. Despite recent advances in systems neuroscience, the biological basis underlying visuomotor functional impairments associated with these clinical conditions is poorly understood. In this study, we used neuroimaging connectomic approaches to map the visuomotor integration (VMI) system in the human brain and investigated the topology approximation of the VMI network to the Allen Human Brain Atla

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Tonn, Bruce. "Will Psychological Disorders Afflict Uploaded Personalities?" World Futures Review 3, no. 4 (2011): 25–34. http://dx.doi.org/10.1177/194675671100300404.

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Uploading human minds into computer systems is an intriguing concept. Will this process become part of our evolutionary future? This paper begins by arguing that successfully replicating human minds in virtual environments will require more than computing power and the ability to transfer the information content of neural connections into computer memory. Virtual minds must also be equipped with certain properties of the human biological mind that may prove to be not easily transferable. These include psychological motivations and even our collective unconsciousness. Lacking these, virtual min

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Hori, Yuki, Justine C. Cléry, Janahan Selvanayagam, et al. "Interspecies activation correlations reveal functional correspondences between marmoset and human brain areas." Proceedings of the National Academy of Sciences 118, no. 37 (2021): e2110980118. http://dx.doi.org/10.1073/pnas.2110980118.

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The common marmoset has enormous promise as a nonhuman primate model of human brain functions. While resting-state functional MRI (fMRI) has provided evidence for a similar organization of marmoset and human cortices, the technique cannot be used to map the functional correspondences of brain regions between species. This limitation can be overcome by movie-driven fMRI (md-fMRI), which has become a popular tool for noninvasively mapping the neural patterns generated by rich and naturalistic stimulation. Here, we used md-fMRI in marmosets and humans to identify whole-brain functional correspond

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Alderman, Sarah L., та Mathilakath M. Vijayan. "11β-Hydroxysteroid dehydrogenase type 2 in zebrafish brain: a functional role in hypothalamus-pituitary-interrenal axis regulation". Journal of Endocrinology 215, № 3 (2012): 393–402. http://dx.doi.org/10.1530/joe-12-0379.

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The type 2, 11β-hydroxysteroid dehydrogenase (Hsd11b2) converts active glucocorticoids to their inactive derivatives (e.g. cortisol to cortisone). In most vertebrates, Hsd11b2 is essential for conferring aldosterone-specific actions in mineralocorticoid target tissues and for protecting glucocorticoid-sensitive tissues during stress. However, teleosts do not synthesize aldosterone, and the function of Hsd11b2 is poorly defined. The distribution of Hsd11b2 in nonmammalian brain is also largely unexplored. We tested the hypothesis that modulation of brain Hsd11b2 activity is involved in stressor

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Lindhe, Örjan, Per Almqvist, Matts Kågedal, et al. "Autoradiographic Mapping of 5-HT1B/1D Binding Sites in the Rhesus Monkey Brain Using [carbonyl-11C]zolmitriptan." International Journal of Molecular Imaging 2011 (October 12, 2011): 1–6. http://dx.doi.org/10.1155/2011/694179.

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Zolmitriptan is a serotonin 5-HT1B/1D receptor agonist that is an effective and well-tolerated drug for migraine treatment. In a human positron emission tomography study, [11C]zolmitriptan crossed the blood-brain barrier but no clear pattern of regional uptake was discernable. The objective of this study was to map the binding of [11C]zolmitriptan in Rhesus monkey brain using whole hemisphere in vitro autoradiography with [11C]zolmitriptan as a radioligand. In saturation studies, [11C]zolmitriptan showed specific (90%) binding to a population of high-affinity binding sites (Kd 0.95–5.06 nM). T

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Dise, Joseph, Christopher Abraham, Douglas Caruthers, Sasa Mutic, and Clifford Robinson. "RADI-19. EVALUATION OF BRAIN METASTASIS LOCAL CONTROL POST RADIOSURGERY VIA MACHINE LEARNING AND RADIOMICS." Neuro-Oncology Advances 1, Supplement_1 (2019): i25. http://dx.doi.org/10.1093/noajnl/vdz014.111.

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Abstract Stereotactic radiosurgery can be used to treat multiple, surgically inaccessible, metastatic brain lesions in a single, minimally invasive outpatient procedure. For brain metastasis, stereotactic radiosurgery can provide excellent local control depending on the robustness of the treatment plan. Previous studies have been performed correlating key radiation planning factors to higher local control probability such as tumor size and maximum dose. However, a separate non-inferiority study demonstrated that higher prescription isodose lines (in excess of 70% or higher) did not correlate t

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Huang, Jie. "A Holistic Analysis of Individual Brain Activity Revealed the Relationship of Brain Areal Activity with the Entire Brain’s Activity." Brain Sciences 13, no. 1 (2022): 6. http://dx.doi.org/10.3390/brainsci13010006.

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The relationship between brain areal activity and the entire brain’s activity is unknown, and understanding this relationship is imperative for understanding the neural mechanisms of human brain function at systems level. The complex activity of human brains varies from area to area and from time to time across the whole brain. BOLD-fMRI measures this spatiotemporal activity at a large-scale systems level. The BOLD time signal of an area reflects a collective neuronal activity of over one million neurons under that area, and the temporal correlation of this time signal with that of every point

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SCHMIDT, G., G. ZAMORA-LÓPEZ, and J. KURTHS. "SIMULATION OF LARGE SCALE CORTICAL NETWORKS BY INDIVIDUAL NEURON DYNAMICS." International Journal of Bifurcation and Chaos 20, no. 03 (2010): 859–67. http://dx.doi.org/10.1142/s0218127410026149.

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Understanding the functional dynamics of the mammalian brain is one of the central aims of modern neuroscience. Mathematical modeling and computational simulations of neural networks can help in this quest. In recent publications, a multilevel model has been presented to simulate the resting-state dynamics of the cortico-cortical connectivity of the mammalian brain. In the present work we investigate how much of the dynamical behavior of the multilevel model can be reproduced by a strongly simplified model. We find that replacing each cortical area by a single Rulkov map recreates the patterns

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Kaufmann, T., K. C. Skåtun, D. Alnæs, et al. "Disintegration of sensorimotor brain networks in schizophrenia." European Psychiatry 33, S1 (2016): S33—S34. http://dx.doi.org/10.1016/j.eurpsy.2016.01.864.

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A large body of literature reported widespread structural and functional abnormalities throughout the brain in schizophrenia spectrum disorders (SZ). Corresponding with the typical symptomatology in SZ where sensory dysfunctions contribute to the core social and cognitive impairment, converging evidence suggests a disturbed interplay between higher-order (cognitive) and lower-order (sensory) regions. This talk will discuss the results of several recent studies, investigating brain connectivity in SZ using functional magnetic resonance imaging data from large samples. Within-network sensorimoto

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Ustinin, M. N., S. D. Rykunov, A. I. Boyko, O. A. Maslova, K. D. Walton, and R. R. Llinás. "Estimation of the Directions of Alpha Rhythm Elementary Sources Using the Method of Human Brain Functional Tomography Based On the Magnetic Encephalography Data." Mathematical Biology and Bioinformatics 13, no. 2 (2018): 426–36. http://dx.doi.org/10.17537/2018.13.426.

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New method for the magnetic encephalography data analysis was proposed. The method transforms multichannel time series into the spatial structure of the human brain activity. In this paper we further develop this method to determine the dominant direction of the electrical sources of brain activity at each node of the calculation grid. We have considered the experimental data, obtained with three 275-channel magnetic encephalographs in New York University, McGill University and Montreal University. The human alpha rhythm phenomenon was selected as a model object. Magnetic encephalograms of the

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Minejeva, Oļesja, Zigurds Markovics, and Nauris Zdanovskis. "BRAIN CONNECTIONS ANALYSIS USING GRAPH THEORY MEASURES." ENVIRONMENT. TECHNOLOGIES. RESOURCES. Proceedings of the International Scientific and Practical Conference 2 (June 20, 2019): 94. http://dx.doi.org/10.17770/etr2019vol2.4141.

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Brain is a part of the organism’s complex structure that performs many functions, which are responsible for the main human abilities: to talk, to hear, to move, to see, etc. The brain consists of several areas that are not only directly connected with the different body systems, but also depend and may affect each other. Researchers and doctors are trying to summarize and visualize these relationships for an important purpose – to get the information about possible reactions of the body in case of various diseases, possibilities of recovery, risks, etc. important issues. Neurologists are looki

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Liwang, Josephine K., Hannah C. Bennett, Hyun-Jae Pi, and Yongsoo Kim. "Protocol for using serial two-photon tomography to map cell types and cerebrovasculature at single-cell resolution in the whole adult mouse brain." STAR Protocols 4, no. 1 (2023): 102048. http://dx.doi.org/10.1016/j.xpro.2023.102048.

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