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Dissertations / Theses on the topic 'WNT/planar cell polarity'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Mei, Xue. "Wnt/planar cell polarity mechanisms in epilepsy and interactions with ciliopathy." Diss., University of Iowa, 2014. https://ir.uiowa.edu/etd/4695.

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The Wnt signaling network has critical roles in embryonic development and is implicated in human disease. One of the outputs of the Wnt network, called the planar cell polarity (PCP) pathway, regulates tissue polarity and directs cell migration. Core PCP components (Frizzled, Dishevelled, Prickle, Vangl, Celsr) localize asymmetrically in polarized cells and establish polarity across the tissue through protein interactions between adjacent cells. The core PCP component activate tissue-specific "effectors" which translate the signal into morphological changes. PCP is related to several disease c

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2

Watson, Julia Alice. "Investigating the role of Wnt/Planar cell polarity (PCP) in Neuromesodermal Progenitors (NMPs)." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31193.

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Neuromesodermal progenitors (NMPs) are bipotent progenitors, located at the caudal end of the embryo and are essential for axis formation. These stem cell-like progenitors possess the ability to self-renew and differentiate to both mesodermal and neural lineages, such as skeletal muscle and spinal cord derivatives. These progenitors arise at E8.5 and are localised in the caudal lateral epiblast (CLE), a posterior region of the embryo near the primitive streak. Later in development, they reside in the tail bud until cessation of axial elongation at E13.5. Throughout these stages NMPs are charac

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3

Schenkelaars, Quentin. "Origine et évolution des voies Wnt chez les métazoaires : étude comparée de diverses espèces d'éponges." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4014.

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Les éponges (Porifera) sont l'une des premières lignées d'animaux à avoir émergé. De ce fait, elles sont considérées comme des espèces clés pour retracer l’origine et l'évolution des gènes et des voies de signalisation qui ont sous-tendu l'apparition de la pluricellularité chez les métazoaires. Entre autres, les voies Wnt ont été décrites comme des cascades génétiques essentielles du control de nombreux mécanismes cellulaires (prolifération, communication, adhésion, motilité, etc.) au cours du développement précoce des bilatériens et des cnidaires. C’est pourquoi, l'étude de ces voies, chez le

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4

Schäfer, Simon Thomas [Verfasser]. "ATP6AP2 is critically involved in adult hippocampal neurogenesis and reveals stage-specific functions for Wnt/ß-Catenin and Wnt/Planar Cell Polarity (PCP) signaling / Simon Thomas Schäfer." Greifswald : Universitätsbibliothek Greifswald, 2015. http://d-nb.info/1069389331/34.

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5

Wu, Mingfu. "A novel non-canonical WNT pathway regulates the asymmetric b cell division in Caenorhabditis elegans." Diss., Kansas State University, 2005. http://hdl.handle.net/2097/355.

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Doctor of Philosophy<br>Department of Biology<br>Michael A. Herman<br>The polarities of several cells that divide asymmetrically during C. elegans development are controlled by Wnt signaling. LIN-44/Wnt and LIN-17/Fz control the polarities of cells in the tail of developing C. elegans larvae, including the male-specific blast cell, B, which divides asymmetrically to generate a larger anterior daughter and a smaller posterior daughter. We determined that the canonical Wnt pathway components are not involved in the control of B cell polarity. However, POP-1/Tcf is involved and asymmetrically dis

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6

Barrott, Jared James. "Wnt5a Signaling Independently of the Planar Cell Polarity Pathway Resulting in Convergent Extension and Neural Tube Closure During Vertebrate Development." Diss., CLICK HERE for online access, 2008. http://contentdm.lib.byu.edu/ETD/image/etd2612.pdf.

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7

Nagy, I. I. (Irina I. ). "Wnt-11 signaling roles during heart and kidney development." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526204666.

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Abstract Organogenesis involves precursor cells proliferation, differentiation along with their coordinated organization into precise multicellular arrangements by planar cell polarity (PCP) pathways. The beta-catenin independent/non-canonical type of Wnt-11 signaling has been known as a PCP modulator during development. In this thesis were analyzed the roles of Wnt-11 in heart and kidney development by using in vivo functional genomics technologies. We show that the Wnt-11 gene is important for murine ventricular myocardium development, since Wnt-11 deficiency in early cardiogenesis leads to

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8

Sun, Simon. "Planar Cell Polarity and Neurodevelopment." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3414.

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Planar cell polarity (PCP) is a developmental signaling mechanism that establishes a polarity within the plane of an epithelium. PCP has been shown to play a role in guiding numerous neurodevelopmental processes such as convergent extension, neuron migration, and axon pathfinding. Certain commissural neurons in the dorsal spinal cord make a series of guidance decisions en route to the brain: first, a ventral projection along the D-V axis, followed by a midline crossing, and after exiting the floorplate, a dorso-anterior turn along the A-P axis. Here, we provide in vivo evidence that the axons

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9

Schamberg, Sabine. "Modelling planar cell polarity in Drosophila melanogaster." Thesis, University of Nottingham, 2009. http://eprints.nottingham.ac.uk/12838/.

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During development, polarity is a common feature of many cell types. One example is the polarisation of whole fields of epithelial cells within the plane of the epithelium, a phenomenon called planar cell polarity (PCP). It is widespread in nature and plays important roles in development and physiology. Prominent examples include the epithelial cells of external structures of insects like the fruit fly Drosophila melanogaster, polarised tissue morphogenesis in vertebrates and sensory hair cells in the vertebrate ear. In this work we focus on the wing and the abdomen of Drosophila, where PCP be

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10

Harumoto, Toshiyuki. "Regulation of Noncentrosomal Microtubules in Planar Cell Polarity." 京都大学 (Kyoto University), 2011. http://hdl.handle.net/2433/142444.

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11

Brzoska, H. L. "Planar cell polarity in kidney development and disease." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1558749/.

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Planar cell polarity (PCP) is a signalling pathway regulating epithelial cell alignment and coordinated organisation, processes that are essential for the development and maintenance of healthy organs and tissues. In this thesis, I hypothesised that the core PCP protein, Celsr1 is essential for normal kidney development. Furthermore, I predicted that PCP proteins would be disrupted in a model of renal disease induced by folic acid. Kidneys of mice homozygous for a mutation in Celsr1 (Celsr1Crsh/Crsh) were significantly smaller compared with wild-type littermates and contained a reduced number

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12

Purdy, Ashley Morgan. "Roles of Planar Cell Polarity Proteins in CoPA Axon Pathfinding." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4289.

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In zebrafish, CoPA (Commissural Primary Ascending) is the first among ascending commissural axons to pathfind anteriorly and form the spinal commissure. One pathway that guides their anterior growth is the planar cell polarity (PCP) signaling pathway, but it is not fully known how PCP signaling regulates anterior guidance. We examined CoPA pathfinding in various PCP mutants to determine if anterior-posterior (A-P) guidance of CoPAs is dependent on PCP signaling. We found that certain PCP mutants exhibited anterior pathfinding defects, with approximately half of all affected CoPAs migrating

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13

Suriben, Rowena Mae Obina. "Dact1 functions in the planar cell polarity pathway during vertebrate gastrulation." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390079.

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14

Barbosa, Filipa Carreira de Avelar. "Regulation of gastrulation movements by planar cell polarity genes in zebrafish." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1444345/.

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During vertebrate gastrulation, mesodermal and ectodermal cells undergo convergent extension (CE), a process characterised by cellular rearrangements in which polarised cells intercalate along the medio-lateral axis leading to elongation of the antero-posterior axis. This thesis aims to prove that genes which have been implicated in the establishment of planar cell polarity (PCP) in Drosophila are conserved in the non-canonical Wnt pathway that regulates CE in zebrafish during gastrulation. Firstly, I analyzed functions of Wnt5 and Wnt 11 ligands and of Fz2 and Fz7 receptors in regulating CE m

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15

Lin, Yung-Yao Steven. "Functional analysis of Prickle isoforms in planar cell polarity in Drosophila." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614719.

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16

Yates, Laura Louise. "The role of the planar cell polarity pathway in branching morphogenesis." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:65200972-a024-4b68-bfd3-a857ec8d99d8.

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The development of organs such as the lung and kidney occurs by branching morphogenesis. Changes in the cytoskeletal architecture, cell-cell adhesion and cell polarity are necessary for the formation of new branches. Interactions and reciprocal signalling between epithelial and mesenchymal cells mediate these organised cell movements that give rise to a complex system of tubes suitable for the transport of gas or fluids. Mutations that disrupt formation of either the correct number, or shape of epithelial branches, affect lung function. This, in turn, can lead to congenital abnormalities such

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17

Tsuji, Takuya. "Long-term preservation of planar cell polarity in reversed tracheal epithelium." Kyoto University, 2018. http://hdl.handle.net/2433/232475.

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18

Freeman, Emily. "Crosstalk Between the Planar Cell Polarity and Hedgehog Signaling Pathways Influences Satellite Cell Fate." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38707.

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Our laboratory has identified two secreted proteins, Wnt7a and Sonic hedgehog (Shh), that regulate satellite cell (SC) fate, during muscle differentiation. While Wnt7a stimulates symmetric SC division through the planar cell polarity (PCP) pathway, Shh activates Myf5 expression in the committed SC following asymmetric division through cilia-mediated Hedgehog (Hh) signaling. Crosstalk between these pathways has been well characterized during development, and is likely to be conserved in muscle regeneration. Indeed, accumulating evidence suggests the PCP pathway influences primary cilia formatio

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19

Rocque, Brittany. "Role of planar cell polarity gene vangl2 in kidney development and disease." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=123086.

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The Planar Cell Polarity (PCP) signaling pathway is crucial for tissue morphogenesis. Vangl2 protein is central in the PCP pathway: its loss is embryonic lethal causing neural tube defects in mice and humans. In the kidney, PCP signaling is thought to be important for the organization of glomerular epithelial cells, podocytes, along the glomerular basement membrane. Podocyte cell protrusions, foot processes (FPs), are critical for kidney filtration functions; loss of FP architecture results in proteinuria and, in severe cases, focal segmental glomerulosclerosis (FSGS). Additionally, an effect

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20

Pryor, S. E. "Planar cell polarity signalling and development of the early mammalian nervous system." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1401159/.

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The vertebrate planar cell polarity (PCP) pathway is an evolutionarily conserved signalling cascade which regulates numerous developmental processes. This thesis investigates the role of PCP signalling in two events, mammalian spinal neurulation and neural crest (NC) cell migration. In mouse embryos PCP signalling is required for initiation of neural tube closure, via regulation of midline convergent extension (CE). In this thesis, a genetic modifying role for the loop-tail (Vangl2Lp) mutation is shown to also predispose to failure of low spinal neurulation. Mutations in the core PCP gene Vang

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21

Shafer, Jeong Deok Beth. "Planar cell polarity pathway and axon guidance in the developing spinal cord." Diss., [La Jolla] : University of California, San Diego, 2010. http://wwwlib.umi.com/cr/ucsd/fullcit?p3397199.

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Thesis (Ph. D.)--University of California, San Diego, 2010.<br>Title from first page of PDF file (viewed March 23, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 95-105).

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22

Tan, Rui Zhen. "Phenomenological Models in Biological Physics: Cell Polarity and rDNA Transcription." Thesis, Harvard University, 2011. http://dissertations.umi.com/gsas.harvard:10000.

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Mathematical modeling has been important in the study of biology. Two main challenges with modeling biological problems are the lack of quantitative data and the complexity of biological problems. With the invention of new techniques, like single molecule transcript counting, very quantitative gene expression measurements at the level of single transcript in individual cells can now be obtained. Biological systems are very complex, involving many reactions and players with unknown reaction rates. To reduce the complexity, scientists have often proposed simplified phenomenological models that a

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23

Pietra, Stefano. "Characterization of New Players in Planar Polarity Establishment in Arabidopsis." Doctoral thesis, Umeå universitet, Institutionen för fysiologisk botanik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-87838.

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Coordinated polarity and differentiation of cells in the plane of a tissue layer are essential to the development of multicellular organisms. Arabidopsis thaliana root hairs and trichomes provide model systems to study the pathways that control planar polarity and cell fate specification in plants. A concentration gradient of the plant hormone auxin provides an instructive cue that coordinates polar assembly of signalling complexes at plasma membranes of root epidermal cells; however, knowledge about additional players and cytoskeletal effectors driving cell polarization prior to hair emergenc

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24

Panzica, Domenico Alessio. "The roles of planar cell polarity signalling in maintaining the adult corneal epithelium." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=227224.

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Cells of the stratified adult corneal epithelium undergo centripetal migration throughout adult life from the edge of the cornea to the centre. To date nothing is known about the mechanism underpinning the oriented cellular migration. Failure to replenish apoptotic cells lost by desquamation from the superficial layer of the corneal epithelium leads to severe pathological conditions that may result in blindness. In this study we investigated the role of planar cell polarity (PCP) core proteins as the guidance cue for centripetal migration in the cornea. Cre-mediated conditional deletion of flo

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25

Visanuvimol, Jiravat. "The Role of vang-1/Van Gogh in Neuronal Polarity in Caenorhabditis elegans." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22762.

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During neuronal development, the axonal and dendritic projections are polarized and oriented along specific body axis. To further explore the molecular basis of neuritogenesis in vivo, we used the nematode Caenorhabditis elegans as a developmental model and performed a forward genetic screen to identify genes that specify the polarity of neurite outgrowth. We examined the VC4 and VC5 neurons, members of the six VC motor neurons using the Pcat-1::gfp transgene cyIs4. The VC motor neurons are ventrally located neurons that extend two processes. VC1, VC2, VC3, and VC6 extend axons along the a

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26

Classen, Anne-Kathrin. "Hexagonal packing of Drosophila wing epithelial cells by the Planar Cell Polarity pathway." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2006. http://nbn-resolving.de/urn:nbn:de:swb:14-1157034530833-40169.

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The mechanisms that order cellular packing geometry are critical for the functioning of many tissues, but are poorly understood. Here we investigate this problem in the developing wing of Drosophila. The surface of the wing is decorated by hexagonally packed hairs that are uniformly oriented towards the distal wing tip. They are constructed by a hexagonal array of wing epithelial cells. We find that wing epithelial cells are irregularly arranged throughout most of development but become hexagonally packed shortly before hair formation. During the process, individual cell junctions grow and shr

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27

Godfrey, Grayland W. II. "Characterizing the Role of Key Planar Cell Polarity Pathway Components in Axon Guidance." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4841.

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An essential process to the development of the neural network of the nervous system is axon guidance. The noncanonical Wnt/Planar Cell Polarity pathway has been identified as an integral component in controlling the projection of axons during axon guidance. Prickle, ROR1 and ROR2 are PCP related proteins that do not have clearly defined roles in the process. This study aims to use zebrafish CoPA neurons as a model to study the roles of Prickle, ROR1, and ROR2 in axon guidance. Using in situ hybridization, morpholino knockdown, and CRISPR/Cas9 loss of function experiments were able to identify

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Meneghini, Marc D. "A MAP kinase-related pathway functions with the Wnt pathway to regulate anterior-posterior polarity in C. elegans /." view abstract or download file of text, 2000. http://wwwlib.umi.com/cr/uoregon/fullcit?p9977911.

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Thesis (Ph. D.)--University of Oregon, 2000.<br>Typescript. Includes vita and abstract. Includes bibliographical references (leaves 76-79). Also available for download via the World Wide Web; free to University of Oregon users.

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Sánchez-Alvarez, Leticia. "Planar Cell Polarity Genes prkl-1 and dsh-1 Polarize C. Elegans Motorneurons during Organogenesis." Thesis, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23513.

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The correct polarity of a neuron underlies its ability to integrate precise circuitries in the nervous system. The goal of my thesis was to investigate the pathways that establish and maintain neuron polarity/orientation in vivo. To accomplish this, I used bipolar VC4/5 motor neurons, which innervate the C. elegans egg-laying musculature, as a model system. Vulval proximal VC4/5 neurons extend axons in the left-right (LR) orientation, around the vulva; whereas vulval distal VC1-3,6 neurons extend axons along the anterior-posterior (AP) axis. A previous study showed that vang-1, a core planar c

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30

Saavedra, Pedro Almeida Dias Guedes. "Pattern formation and planar cell polarity in Drosophila larval development : insights from the ventral epidermis." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708010.

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31

Zhao, Xuesong. "Role of the drosophila cadherin fat in regulating tissue size and planar cell polarity signaling /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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32

Han, Suhao. "Interaction of centrosomal component SPD-5 with Wnt signals in the control of cell polarity in Caenorhabditis elegans." Diss., Kansas State University, 2012. http://hdl.handle.net/2097/14716.

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Doctor of Philosophy<br>Department of Biology<br>Michael A. Herman<br>All multicellular organisms consist of a variety of cell types. One of the mechanisms to generate this cellular diversity is the asymmetric cell division, which requires the establishment of cell polarity. In Caenorhabditis elegans hermaphrodites, 807 of 949 somatic cell divisions are asymmetric. The centrosome and the Wnt signaling pathway both have been shown to regulate cell polarity and subsequently asymmetric divisions in many model organisms. However, it is not clear whether the Wnt signaling pathway manipulates the ce

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Naillat, F. (Florence). "Roles of Wnt4/5a in germ cell differentiation and gonad development & ErbB4 in polarity of kidney epithelium." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295751.

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Abstract The embryonic urogenital system generates the metanephric kidneys, the gonads and the adrenal glands, and its development is based on sequential and reciprocal cell and tissue interactions. The mechanisms which regulate urogenital ontogeny are still poorly understood. In this thesis, the roles of Wnt-4 and ErbB4 functions in gonad and kidney development were analysed by using in vivo functional genomic technologies. Wnt-4 is crucial in female development since its absence leads to a partial female to male sex reversal. We found that Wnt-4 mediated the interactions between the somatic

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34

Staple, Douglas. "Understanding Mechanics and Polarity in Two-Dimensional Tissues." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-85622.

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During development, cells consume energy, divide, rearrange, and die. Bulk properties such as viscosity and elasticity emerge from cell-scale mechanics and dynamics. Order appears, for example in patterns of hair outgrowth, or in the predominately hexagonal pattern of cell boundaries in the wing of a fruit fly. In the past fifty years, much progress has been made in understanding tissues as living materials. However, the physical mechanisms underlying tissue-scale behaviour are not completely understood. Here we apply theories from statistical physics and fluid dynamics to understand mech

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Crompton, Lucy Annabel. "Investigation into the role of planar cell polarity in axis formation of the early mammalian embryo." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485550.

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In the early mammalian embryo cells undergo differentiation into specific lineages, which are assembled into a blueprint for the matwe body plan. This blueprint consists of is the three definitive embryonic axis, anteriorposterior, dorso-ventral and left-right. The first axis to be established is the anterior-posterior axis. Two critical events in anterior-posterior axis development are the induction and migration of the Anterior Visceral Endoderm (AVE) at 5.5 days post coitum (dpc) and gastrulation at 6.5 dpc. The AVE is a signaling centre.required for anterior specification. Gastrulation is

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Seo, Jung Hwa. "Mutations in the Planar Cell Polarity gene, Fuzzy, are associated with neural tube defects in humans." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106542.

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The planar cell polarity (PCP) pathway is evolutionally conserved from flies to vertebrate; it controls multiple cellular processes during embryonic development. One of such processes is neurulation, which gives rise to the brain and spinal cord. Mutations in the PCP genes in mice cause a very severe neural tube defect (NTD), called craniorachischisis, establishing that the PCP pathway is an important regulator of neural tube closure. NTDs are the second most common congenital malformation in humans. Since the etiology of NTDs in humans is complex and involves both genetic and environmental fa

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Oteiza, Alvarez Pablo. "Role of the Planar Cell Polarity Pathway in the Morphogenesis of the Laterality Organ in Zebrafish." Tesis, Universidad de Chile, 2009. http://www.repositorio.uchile.cl/handle/2250/110540.

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A pesar de su aparente simetría bilateral, el plan corporal de los vertebrados presenta consitentes asimetrías en localización, estructura y función de diversos órganos internos como el corazón, los intestinos y el cerebro. Los mecanismos mediante los cuales el eje izquierda-derecha se establece durante el desarrollo embrionario han evolucionado desde arreglamientos cito esqueléticos y flujos iónicos tempranos hacia la actividad de estructuras ciliadas transigentes. Se ha propuesto que la actividad de los cilios en estas estructuras (denominadas órganos de lateralidad) genera un flujo extracel

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Low, Keri Lynn. "FGF4 and Wnt5a/PCP signaling promote limb outgrowth by polarizing limb mesenchyme /." Diss., CLICK HERE for online access, 2006. http://contentdm.lib.byu.edu/ETD/image/etd1612.pdf.

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Chen, Wei-Shen. "Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular planar cell polarity signaling in drosophila melanogaster /." May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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Carr, David A. "The Role of Farnesyltransferase β-subunit in Neuronal Polarity in Caenorhabditis Elegans". Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23784.

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Little is known about the molecular components and interactions of the planar cell polarity pathway that regulate neuronal polarity. This study uses a prkl-1 induced backwards locomotion defect as an array to perform a prkl-1 suppressor screen in C. elegans looking for new components of the planar cell polarity pathway involved in the neuronal polarization of VC4 and VC5. The screen discovered twelve new alleles of vang-1, one new allele of fntb-1 and five new mutations in unknown polarity genes. fntb-1 encodes for the worm ortholog of Farnesyltransferase β-subunit and is important for neur

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Tanner, Raymond. "A Role for the Planar Cell Polarity Pathway in Neuronal Positioning Along the AP Axis of C. elegans." Thesis, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31521.

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We sought to investigate the role of the Planar Cell Polarity (PCP) pathway in neuronal positioning along the Anterior-Posterior (AP) axis of C. elegans, and chose the worm’s DD-type motor neurons as a model. The six DD neurons (DD1-DD6) are evenly spaced in the ventral nerve cord of wild type animals. Here we showed that mutations in core PCP genes caused DD neuron spacing and positioning defects. prkl-1 double mutant combinations with vang-1 and fmi-1 showed a suppression of the more severe prkl-1 single mutant defects, which was evidence of genetic interactions between these PCP componen

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Gao, Qian. "A systems biology approach to multi-scale modelling and analysis of planar cell polarity in Drosophila melanogaster wing." Thesis, Brunel University, 2013. http://bura.brunel.ac.uk/handle/2438/7478.

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Systems biology aims to describe and understand biology at a global scale where biological systems function as a result of complex mechanisms that happen at several scales. Modelling and simulation are computational tools that are invaluable for description, understanding and prediction these mechanisms in a quantitative and integrative way. Thus multi-scale methods that couple the design, simulation and analysis of models spanning several spatial and temporal scales is becoming a new emerging focus of systems biology. This thesis uses an exemplar – Planar cell polarity (PCP) signalling – to i

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Organisti, Cristina. "The planar cell polarity regulator Flamingo cooperates with Netrin/Frazzled signaling during axon targeting in the Drosophila embryonic CNS." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-181615.

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Sasselli, V. "The potential role of Rac signalling and the planar cell polarity pathway in wiring of the enteric nervous system." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1318135/.

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The functional development of the enteric nervous system (ENS) requires newly generated neurons and their progenitors to migrate to their appropriate sites, extend neurites, guide axons and dendrites to suitable locations and establish synaptic connections with the appropriate targets. Very little is known about the molecular mechanism underlying these processes. Recent studies have suggested a potential role of Rho GTPases as intracellular regulators of several ENS developmental processes. However, the relative participation of specific members of the family in migration, neurogenesis and axo

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Zanconato, Francesca. "Dissecting TAZ biology: mechanisms and regulations." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3426291.

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The central theme of this thesis is TAZ, a transcriptional co-activator that works - together with its homologue YAP - as transducer of the mammalian Hippo pathway. Since the beginning of my PhD training, I have been involved in the investigation of TAZ function and regulation in breast cancer stem cells. Our findings established TAZ as a molecular determinant of self-renewal and tumorigenic potential in breast cancer cells. Indeed, the vast majority of high grade breast tumors (known to be enriched with cancer stem cells) display a strong positive staining for TAZ, compared with normal mamma

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Gegg, Moritz Verfasser], Angelika [Akademischer Betreuer] [Schnieke, and Heiko [Akademischer Betreuer] Lickert. "Identification and characterization of the novel planar cell polarity gene Flattop (Fltp) / Moritz Gegg. Gutachter: Heiko Lickert ; Angelika Schnieke. Betreuer: Angelika Schnieke." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1060825481/34.

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Organisti, Cristina [Verfasser], and Rüdiger [Akademischer Betreuer] Klein. "The planar cell polarity regulator Flamingo cooperates with Netrin/Frazzled signaling during axon targeting in the Drosophila embryonic CNS / Cristina Organisti. Betreuer: Rüdiger Klein." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1069743720/34.

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Pietilä, I. (Ilkka). "The role of Dkk1 and Wnt5a in mammalian kidney development and disease." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526207216.

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Abstract This thesis focuses on mammalian kidney development and in particular on the question of how two Wnt signalling pathway genes, an antagonistic Dkk1 and an agonistic ligand Wnt5a, regulate the process. Wnts are secreted ligands that are involved in many developmental processes, including gonadal differentiation and kidney development, but also in various diseases and malformations. Wnts form a large signalling family containing 19 different glycoprotein ligands in mammals. Wnt signalling occurs via two different intracellular pathways. A canonical pathway proceeds via beta-catenin, and

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Donati, Antoine. "Planar polarization of a mono-ciliated epithelium : the zebrafish floor-plate." Electronic Thesis or Diss., Sorbonne université, 2019. http://www.theses.fr/2019SORUS078.

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La polarité cellulaire planaire (PCP) des cils motiles permet de générer des flux directionnels dans les cavités corporelles des animaux. Cependant les mécanismes de cette polarisation sont mal compris. Nous utilisons ici le plancher de poisson-zèbre pour étudier ces mécanismes. A l'aide d'échantillons fixés et d'imagerie sur embryon vivant, nous montrons que le positionnement postérieur des cils du plancher est progressif et asynchrone entre cellules voisines. Au cours du développement, les corps basaux (CB, centrioles à la base des cils) passent de plus en plus de temps en contact avec la me

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Delobel, Valentin. "Identification de la protéine "Mutated in Colorectal Cancer" (MCC) comme un nouvel acteur de la voie WNT dans l'organisation polaire du plexus." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0137.

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La signalisation Wnt joue un rôle clé dans le développement d'un plexus vasculaire fonctionnel, assurant ainsi l'homéostasie des tissus. Son dysfonctionnement peut conduire à des pathologies vasculaires telles que les rétinopathies ou les démences. Cependant, les mécanismes moléculaires par lesquels cette voie régule l'architecture vasculaire restent encore mal compris. Dans cette étude, nous avons identifié la protéine « Mutated in Colorectal Cancer » (MCC) comme un nouveau composant de la voie Wnt non canonique de polarité planaire(PCP) dans les cellules endothéliales (CE). In vitro, nous av

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