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Journal articles on the topic 'WNT/planar cell polarity'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Barrow, Jeffery R. "Wnt/planar cell polarity signaling." Organogenesis 7, no. 4 (2011): 260–66. http://dx.doi.org/10.4161/org.7.4.19049.

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2

Andre, Philipp, Qianyi Wang, Na Wang, et al. "The Wnt Coreceptor Ryk Regulates Wnt/Planar Cell Polarity by Modulating the Degradation of the Core Planar Cell Polarity Component Vangl2." Journal of Biological Chemistry 287, no. 53 (2012): 44518–25. http://dx.doi.org/10.1074/jbc.m112.414441.

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3

Funato, Yosuke, Tatsuo Michiue, Takeshi Terabayashi, et al. "Nucleoredoxin regulates the Wnt/planar cell polarity pathway inXenopus." Genes to Cells 13, no. 9 (2008): 965–75. http://dx.doi.org/10.1111/j.1365-2443.2008.01220.x.

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4

Yu, Joyce J. S., Aude Maugarny-Calès, Stéphane Pelletier, et al. "Frizzled-Dependent Planar Cell Polarity without Secreted Wnt Ligands." Developmental Cell 54, no. 5 (2020): 583–92. http://dx.doi.org/10.1016/j.devcel.2020.08.004.

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5

Kim, Sun K., Siwei Zhang, Michael E. Werner, et al. "CLAMP/Spef1 regulates planar cell polarity signaling and asymmetric microtubule accumulation in the Xenopus ciliated epithelia." Journal of Cell Biology 217, no. 5 (2018): 1633–41. http://dx.doi.org/10.1083/jcb.201706058.

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Most epithelial cells polarize along the axis of the tissue, a feature known as planar cell polarity (PCP). The initiation of PCP requires cell–cell signaling via the noncanonical Wnt/PCP pathway. Additionally, changes in the cytoskeleton both facilitate and reflect this polarity. We have identified CLAMP/Spef1 as a novel regulator of PCP signaling. In addition to decorating microtubules (MTs) and the ciliary rootlet, a pool of CLAMP localizes at the apical cell cortex. Depletion of CLAMP leads to the loss of PCP protein asymmetry, defects in cilia polarity, and defects in the angle of cell di

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6

Miyagi, Chiemi, Susumu Yamashita, Yusuke Ohba, Hisayoshi Yoshizaki, Michiyuki Matsuda, and Toshio Hirano. "STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension." Journal of Cell Biology 166, no. 7 (2004): 975–81. http://dx.doi.org/10.1083/jcb.200403110.

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Zebrafish signal transducer and activator of transcription 3 (STAT3) controls the cell movements during gastrulation. Here, we show that noncell-autonomous activity of STAT3 signaling in gastrula organizer cells controls the polarity of neighboring cells through Dishevelled-RhoA signaling in the Wnt-planar cell polarity (Wnt-PCP) pathway. In STAT3-depleted embryos, although all the known molecules in the Wnt-PCP pathway were expressed normally, the RhoA activity in lateral mesendodermal cells was down-regulated, resulting in severe cell polarization defects in convergence and extension movemen

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7

Yang, Yingzi, and Marek Mlodzik. "Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)." Annual Review of Cell and Developmental Biology 31, no. 1 (2015): 623–46. http://dx.doi.org/10.1146/annurev-cellbio-100814-125315.

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8

Goggolidou, Paraskevi. "Wnt and planar cell polarity signaling in cystic renal disease." Organogenesis 10, no. 1 (2013): 86–95. http://dx.doi.org/10.4161/org.26766.

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9

Daulat, Avais M., and Jean-Paul Borg. "Wnt/Planar Cell Polarity Signaling: New Opportunities for Cancer Treatment." Trends in Cancer 3, no. 2 (2017): 113–25. http://dx.doi.org/10.1016/j.trecan.2017.01.001.

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10

Ganner, Athina, Soeren Lienkamp, and Gerd Walz. "Planar cell polarity (PCP) and Wnt signaling in renal disease." Drug Discovery Today: Disease Mechanisms 10, no. 3-4 (2013): e159-e166. http://dx.doi.org/10.1016/j.ddmec.2013.12.001.

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11

Gajos-Michniewicz, Anna, and Malgorzata Czyz. "WNT Signaling in Melanoma." International Journal of Molecular Sciences 21, no. 14 (2020): 4852. http://dx.doi.org/10.3390/ijms21144852.

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WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: β-catenin-dependent signaling (canonical pathway) and β-catenin-independent signaling (non-canonical pathway), the latter can be further divided into WNT/planar cell polarity (PCP) and calcium pathways. WNT ligands are considered as unique directional growth factors that contribute to both cell proliferation and polarity. Origin of cancer can be div

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12

Najarro, Elvis Huarcaya, Jennifer Huang, Adrian Jacobo, Lee A. Quiruz, Nicolas Grillet, and Alan G. Cheng. "Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea." Development 147, no. 19 (2020): dev191981. http://dx.doi.org/10.1242/dev.191981.

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ABSTRACTPlanar cell polarity (PCP) proteins localize asymmetrically to instruct cell polarity within the tissue plane, with defects leading to deformities of the limbs, neural tube and inner ear. Wnt proteins are evolutionarily conserved polarity cues, yet Wnt mutants display variable PCP defects; thus, how Wnts regulate PCP remains unresolved. Here, we have used the developing cochlea as a model system to show that secreted Wnts regulate PCP through polarizing a specific subset of PCP proteins. Conditional deletion of Wntless or porcupine, both of which are essential for secretion of Wnts, ca

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13

Vladar, Eszter K., and Melanie Königshoff. "Noncanonical Wnt planar cell polarity signaling in lung development and disease." Biochemical Society Transactions 48, no. 1 (2020): 231–43. http://dx.doi.org/10.1042/bst20190597.

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The planar cell polarity (PCP) signaling pathway is a potent developmental regulator of directional cell behaviors such as migration, asymmetric division and morphological polarization that are critical for shaping the body axis and the complex three-dimensional architecture of tissues and organs. PCP is considered a noncanonical Wnt pathway due to the involvement of Wnt ligands and Frizzled family receptors in the absence of the beta-catenin driven gene expression observed in the canonical Wnt cascade. At the heart of the PCP mechanism are protein complexes capable of generating molecular asy

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14

Wang, Yingqun. "Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy." Molecular Cancer Therapeutics 8, no. 8 (2009): 2103–9. http://dx.doi.org/10.1158/1535-7163.mct-09-0282.

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15

Chen, Y., R. J. W. Stump, F. J. Lovicu, and J. W. McAvoy. "A role for Wnt/planar cell polarity signaling during lens fiber cell differentiation?" Seminars in Cell & Developmental Biology 17, no. 6 (2006): 712–25. http://dx.doi.org/10.1016/j.semcdb.2006.11.005.

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16

Artus, Cédric, Fabienne Glacial, Kayathiri Ganeshamoorthy, et al. "The Wnt/Planar Cell Polarity Signaling Pathway Contributes to the Integrity of Tight Junctions in Brain Endothelial Cells." Journal of Cerebral Blood Flow & Metabolism 34, no. 3 (2013): 433–40. http://dx.doi.org/10.1038/jcbfm.2013.213.

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Wnt morphogens released by neural precursor cells were recently reported to control blood–brain barrier (BBB) formation during development. Indeed, in mouse brain endothelial cells, activation of the Wnt/ β-catenin signaling pathway, also known as the canonical Wnt pathway, was shown to stabilize endothelial tight junctions (TJs) through transcriptional regulation of the expression of TJ proteins. Because Wnt proteins activate several distinct β-catenin-dependent and independent signaling pathways, this study was designed to assess whether the noncanonical Wnt/Par/aPKC planar cell polarity (PC

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17

Guillabert-Gourgues, Aude, Beatrice Jaspard-Vinassa, Marie-Lise Bats, et al. "Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity–signaling pathway." Molecular Biology of the Cell 27, no. 6 (2016): 941–53. http://dx.doi.org/10.1091/mbc.e14-08-1332.

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Angiogenesis involves the coordinated growth and migration of endothelial cells (ECs) toward a proangiogenic signal. The Wnt planar cell polarity (PCP) pathway, through the recruitment of Dishevelled (Dvl) and Dvl-associated activator of morphogenesis (Daam1), has been proposed to regulate cell actin cytoskeleton and microtubule (MT) reorganization for oriented cell migration. Here we report that Kif26b—a kinesin—and Daam1 cooperatively regulate initiation of EC sprouting and directional migration via MT reorganization. First, we find that Kif26b is recruited within the Dvl3/Daam1 complex. Usi

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18

Hikasa, Hiroki, Mikihito Shibata, Ichiro Hiratani, and Masanori Taira. "TheXenopusreceptor tyrosine kinase Xror2 modulates morphogenetic movements of the axial mesoderm and neuroectoderm via Wnt signaling." Development 129, no. 22 (2002): 5227–39. http://dx.doi.org/10.1242/dev.129.22.5227.

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The Spemann organizer plays a central role in neural induction, patterning of the neuroectoderm and mesoderm, and morphogenetic movements during early embryogenesis. By seeking genes whose expression is activated by the organizer-specific LIM homeobox gene Xlim-1 in Xenopusanimal caps, we isolated the receptor tyrosine kinase Xror2. Xror2 is expressed initially in the dorsal marginal zone, then in the notochord and the neuroectoderm posterior to the midbrain-hindbrain boundary. mRNA injection experiments revealed that overexpression of Xror2 inhibits convergent extension of the dorsal mesoderm

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19

Eisenberg, Leonard M., and Carol A. Eisenberg. "Evaluating the Role of Wnt Signal Transduction in Promoting the Development of the Heart." Scientific World JOURNAL 7 (2007): 161–76. http://dx.doi.org/10.1100/tsw.2007.71.

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Wnts are a family of secreted signaling proteins that are encoded by 19 distinct genes in the vertebrate genome. These molecules initiate several signal transduction pathways: the canonical Wnt, Wnt/Ca2+, and Wnt/planar cell polarity pathways. Wnt proteins have major impact on embryonic development, tumor progression, and stem cell differentiation. Wnt signal transduction also influences the formation of the heart, yet many issues concerning the involvement of Wnt regulation in initiating cardiac development remain unresolved. In this review, we will examine the published record to discern (a)

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20

Cong, Feng, Liang Schweizer та Harold Varmus. "Casein Kinase Iε Modulates the Signaling Specificities of Dishevelled". Molecular and Cellular Biology 24, № 5 (2004): 2000–2011. http://dx.doi.org/10.1128/mcb.24.5.2000-2011.2004.

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ABSTRACT Wnt signaling is critical to many aspects of development, and aberrant activation of the Wnt signaling pathway can cause cancer. Dishevelled (Dvl) protein plays a central role in this pathway by transducing the signal from the Wnt receptor complex to the β-catenin destruction complex. Dvl also plays a pivotal role in the planar cell polarity pathway that involves the c-Jun N-terminal kinase (JNK). How functions of Dvl are regulated in these two distinct pathways is not clear. We show that deleting the C-terminal two-thirds of Dvl, which includes the PDZ and DEP domains and is essentia

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21

Walczyńska, Katarzyna S., Ling Zhu, and Yujun Liang. "Insights into the role of the Wnt signaling pathway in the regeneration of animal model systems." International Journal of Developmental Biology 67, no. 3 (2023): 65–78. http://dx.doi.org/10.1387/ijdb.220144yl.

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Regeneration enables the regrowth and restoration of missing body parts. It is a common phenomenon among animals. However, only some species exhibit remarkable regeneration capabilities and can regenerate organs such as limbs, lenses or hearts. Regeneration has been widely studied, thereby giving rise to new fields, such as regenerative medicine. Furthermore, regeneration has the potential to be applied to the human body. However, the molecular mechanisms governing this process should be elucidated first. Recent advancements in research methods have led to the identification of numerous signal

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22

HE, PING, SHUHENG JIANG, MINGZE MA, et al. "Trophoblast glycoprotein promotes pancreatic ductal adenocarcinoma cell metastasis through Wnt/planar cell polarity signaling." Molecular Medicine Reports 12, no. 1 (2012): 503–9. http://dx.doi.org/10.3892/mmr.2015.3412.

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23

Kestler, Hans A., and Michael Kühl. "From individual Wnt pathways towards a Wnt signalling network." Philosophical Transactions of the Royal Society B: Biological Sciences 363, no. 1495 (2008): 1333–47. http://dx.doi.org/10.1098/rstb.2007.2251.

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Wnt proteins play important roles during vertebrate and invertebrate development. They obviously have the ability to activate different intracellular signalling pathways. Based on the characteristic intracellular mediators used, these are commonly described as the Wnt/β-catenin, the Wnt/calcium and the Wnt/Jun N-terminal kinase pathways (also called planar cell polarity pathway). In the past, these different signalling events were mainly described as individual and independent signalling branches. Here, we discuss the possibility that Wnt proteins activate a complex intracellular signalling ne

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24

Zheng, Chaogu, Margarete Diaz-Cuadros, and Martin Chalfie. "Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans." Proceedings of the National Academy of Sciences 112, no. 43 (2015): 13243–48. http://dx.doi.org/10.1073/pnas.1518686112.

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Wnt proteins regulate axonal outgrowth along the anterior–posterior axis, but the intracellular mechanisms that modulate the strength of Wnt signaling in axon guidance are largely unknown. Using the Caenorhabditis elegans mechanosensory PLM neurons, we found that posteriorly enriched LIN-44/Wnt acts as a repellent to promote anteriorly directed neurite outgrowth through the LIN-17/Frizzled receptor, instead of controlling neuronal polarity as previously thought. Dishevelled (Dsh) proteins DSH-1 and MIG-5 redundantly mediate the repulsive activity of the Wnt signals to induce anterior outgrowth

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25

Sheldahl, Laird C., Diane C. Slusarski, Petra Pandur, Jeffrey R. Miller, Michael Kühl, and Randall T. Moon. "Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos." Journal of Cell Biology 161, no. 4 (2003): 769–77. http://dx.doi.org/10.1083/jcb.200211094.

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Wnt ligands and Frizzled (Fz) receptors have been shown to activate multiple intracellular signaling pathways. Activation of the Wnt–β-catenin pathway has been described in greatest detail, but it has been reported that Wnts and Fzs also activate vertebrate planar cell polarity (PCP) and Wnt–Ca2+ pathways. Although the intracellular protein Dishevelled (Dsh) plays a dual role in both the Wnt–β-catenin and the PCP pathways, its potential involvement in the Wnt–Ca2+ pathway has not been investigated. Here we show that a Dsh deletion construct, XDshΔDIX, which is sufficient for activation of the

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26

Macheda, Maria L., Willy W. Sun, Kumudhini Kugathasan, et al. "The Wnt Receptor Ryk Plays a Role in Mammalian Planar Cell Polarity Signaling." Journal of Biological Chemistry 287, no. 35 (2012): 29312–23. http://dx.doi.org/10.1074/jbc.m112.362681.

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27

Descamps, Betty, Raj Sewduth, Nancy Ferreira Tojais, et al. "Frizzled 4 Regulates Arterial Network Organization Through Noncanonical Wnt/Planar Cell Polarity Signaling." Circulation Research 110, no. 1 (2012): 47–58. http://dx.doi.org/10.1161/circresaha.111.250936.

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28

Kurolap, A., C. Chai Gadot, O. Eshach Adiv, et al. "236 Wnt/planar cell polarity impairment and the genetics of yellow nail syndrome." Journal of Investigative Dermatology 144, no. 12 (2024): S269. http://dx.doi.org/10.1016/j.jid.2024.10.244.

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29

Ahmad, Samar, and Liliana Attisano. "Wnt5a Promotes Axon Elongation in Coordination with the Wnt–Planar Cell Polarity Pathway." Cells 13, no. 15 (2024): 1268. http://dx.doi.org/10.3390/cells13151268.

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The establishment of neuronal polarity, involving axon specification and outgrowth, is critical to achieve the proper morphology of neurons, which is important for neuronal connectivity and cognitive functions. Extracellular factors, such as Wnts, modulate diverse aspects of neuronal morphology. In particular, non-canonical Wnt5a exhibits differential effects on neurite outgrowth depending upon the context. Thus, the role of Wnt5a in axon outgrowth and neuronal polarization is not completely understood. In this study, we demonstrate that Wnt5a, but not Wnt3a, promotes axon outgrowth in dissoci

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30

Gao, Bo, Hai Song, Kevin Bishop, et al. "Wnt Signaling Gradients Establish Planar Cell Polarity by Inducing Vangl2 Phosphorylation through Ror2." Developmental Cell 20, no. 2 (2011): 163–76. http://dx.doi.org/10.1016/j.devcel.2011.01.001.

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31

Shami Shah, Adnan, Alex G. Batrouni, Dongsung Kim, et al. "PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling." Cell Reports 27, no. 7 (2019): 2157–70. http://dx.doi.org/10.1016/j.celrep.2019.04.060.

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32

Ewen-Campen, Ben, Typhaine Comyn, Eric Vogt, and Norbert Perrimon. "No Evidence that Wnt Ligands Are Required for Planar Cell Polarity in Drosophila." Cell Reports 32, no. 10 (2020): 108121. http://dx.doi.org/10.1016/j.celrep.2020.108121.

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33

He, Chun-Wei, Chien-Po Liao, and Chun-Liang Pan. "Wnt signalling in the development of axon, dendrites and synapses." Open Biology 8, no. 10 (2018): 180116. http://dx.doi.org/10.1098/rsob.180116.

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Wnts are a highly conserved family of secreted glycoproteins that play essential roles in the morphogenesis and body patterning during the development of metazoan species. In recent years, mounting evidence has revealed important functions of Wnt signalling in diverse aspects of neural development, including neuronal polarization, guidance and branching of the axon and dendrites, as well as synapse formation and its structural remodelling. In contrast to Wnt signalling in cell proliferation and differentiation, which mostly acts through β-catenin-dependent pathways, Wnts engage a diverse array

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34

Yamamoto, Shinji, Osamu Nishimura, Kazuyo Misaki, et al. "Cthrc1 Selectively Activates the Planar Cell Polarity Pathway of Wnt Signaling by Stabilizing the Wnt-Receptor Complex." Developmental Cell 15, no. 1 (2008): 23–36. http://dx.doi.org/10.1016/j.devcel.2008.05.007.

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35

Kraft, Bianca, Corinna D. Berger, Veronika Wallkamm, Herbert Steinbeisser, and Doris Wedlich. "Wnt-11 and Fz7 reduce cell adhesion in convergent extension by sequestration of PAPC and C-cadherin." Journal of Cell Biology 198, no. 4 (2012): 695–709. http://dx.doi.org/10.1083/jcb.201110076.

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Wnt-11/planar cell polarity signaling polarizes mesodermal cells undergoing convergent extension during Xenopus laevis gastrulation. These shape changes associated with lateral intercalation behavior require a dynamic modulation of cell adhesion. In this paper, we report that Wnt-11/frizzled-7 (Fz7) controls cell adhesion by forming separate adhesion-modulating complexes (AMCs) with the paraxial protocadherin (PAPC; denoted as AMCP) and C-cadherin (denoted as AMCC) via distinct Fz7 interaction domains. When PAPC was part of a Wnt-11–Fz7 complex, its Dynamin1- and clathrin-dependent internaliza

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36

Lin, Jianqiong, and Zhicao Yue. "Coupling of apical-basal polarity and planar cell polarity to interpret the Wnt signaling gradient in feather development." Development 145, no. 17 (2018): dev162792. http://dx.doi.org/10.1242/dev.162792.

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37

Ahmad, Samar, Tania Christova, Melanie Pye, et al. "Small Extracellular Vesicles Promote Axon Outgrowth by Engaging the Wnt-Planar Cell Polarity Pathway." Cells 14, no. 1 (2025): 56. https://doi.org/10.3390/cells14010056.

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In neurons, the acquisition of a polarized morphology is achieved upon the outgrowth of a single axon from one of several neurites. Small extracellular vesicles (sEVs), such as exosomes, from diverse sources are known to promote neurite outgrowth and thus may have therapeutic potential. However, the effect of fibroblast-derived exosomes on axon elongation in neurons of the central nervous system under growth-permissive conditions remains unclear. Here, we show that fibroblast-derived sEVs promote axon outgrowth and a polarized neuronal morphology in mouse primary embryonic cortical neurons. Me

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38

Mayor, Roberto, and Eric Theveneau. "The role of the non-canonical Wnt–planar cell polarity pathway in neural crest migration." Biochemical Journal 457, no. 1 (2013): 19–26. http://dx.doi.org/10.1042/bj20131182.

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The neural crest is an embryonic stem cell population whose migratory behaviour has been likened to malignant invasion. The neural crest, as does cancer, undergoes an epithelial-to-mesenchymal transition and migrates to colonize almost all the tissues of the embryo. Neural crest cells exhibit collective cell migration, moving in streams of high directionality. The migratory neural crest streams are kept in shape by the presence of negative signals in their vicinity. The directionality of the migrating neural crest is achieved by contact-dependent cell polarization, in a phenomenon called conta

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39

de Jesus Perez, Vinicio A., Ziad Ali, Tero-Pekka Alastalo, et al. "BMP promotes motility and represses growth of smooth muscle cells by activation of tandem Wnt pathways." Journal of Cell Biology 192, no. 1 (2011): 171–88. http://dx.doi.org/10.1083/jcb.201008060.

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We present a novel cell-signaling paradigm in which bone morphogenetic protein 2 (BMP-2) consecutively and interdependently activates the wingless (Wnt)–β-catenin (βC) and Wnt–planar cell polarity (PCP) signaling pathways to facilitate vascular smooth muscle motility while simultaneously suppressing growth. We show that BMP-2, in a phospho-Akt–dependent manner, induces βC transcriptional activity to produce fibronectin, which then activates integrin-linked kinase 1 (ILK-1) via α4-integrins. ILK-1 then induces the Wnt–PCP pathway by binding a proline-rich motif in disheveled (Dvl) and consequen

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40

Nascone-Yoder, Nanette, and Michael Dush. "Wnt/planar cell polarity signaling controls endoderm cell rearrangements during the morphogenesis of the primitive gut tube." Developmental Biology 331, no. 2 (2009): 450. http://dx.doi.org/10.1016/j.ydbio.2009.05.237.

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41

Yang, Wei, Lisa Garrett, Di Feng, et al. "Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development." Cell Research 27, no. 12 (2017): 1466–84. http://dx.doi.org/10.1038/cr.2017.127.

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42

Sokol, Sergei Y. "Spatial and temporal aspects of Wnt signaling and planar cell polarity during vertebrate embryonic development." Seminars in Cell & Developmental Biology 42 (June 2015): 78–85. http://dx.doi.org/10.1016/j.semcdb.2015.05.002.

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43

Zuriaga, Maria A., Jose J. Fuster, Susan Maclauchlan, Noyan Gokce, and Kenneth Walsh. "Coordinated activation of WNT/planar cell polarity signaling in inflamed visceral fat of obese individuals." Atherosclerosis 263 (August 2017): e8. http://dx.doi.org/10.1016/j.atherosclerosis.2017.06.052.

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44

Lee, Yen-Hua, Koichi Kawakami, Wei-Chun HuangFu, and I.-Hsuan Liu. "Chondroitin sulfate proteoglycan 4 regulates zebrafish body axis organization via Wnt/planar cell polarity pathway." PLOS ONE 15, no. 4 (2020): e0230943. http://dx.doi.org/10.1371/journal.pone.0230943.

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45

Randall, Rachel M., Yvonne Y. Shao, Lai Wang, and R. Tracy Ballock. "Activation of Wnt Planar cell polarity (PCP) signaling promotes growth plate column formation in vitro." Journal of Orthopaedic Research 30, no. 12 (2012): 1906–14. http://dx.doi.org/10.1002/jor.22152.

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46

Anchesi, Ivan, Federica Betto, Luigi Chiricosta, et al. "Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study." Plants 12, no. 1 (2023): 193. http://dx.doi.org/10.3390/plants12010193.

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Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the Cannabis sativa L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequencing (NGS) technology. Analysis showed the activation of the WNT/planar cell polarity (PCP) pathway and Ephrin-Eph signaling. The results revealed that CBG increases the expression of genes associated with the onset process of cytoskeletal remodeling and axon guidance.

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47

Feng, Di, Jin Wang, Wei Yang, et al. "Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7–mediated Vangl ubiquitination and endoplasmic reticulum–associated degradation." Science Advances 7, no. 20 (2021): eabg2099. http://dx.doi.org/10.1126/sciadv.abg2099.

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The four-pass transmembrane proteins Vangl1 and Vangl2 are dedicated core components of Wnt/planar cell polarity (Wnt/PCP) signaling that critically regulate polarized cell behaviors in many morphological and physiological processes. Here, we found that the abundance of Vangl proteins is tightly controlled by the ubiquitin-proteasome system through endoplasmic reticulum–associated degradation (ERAD). The key ERAD component p97/VCP directly binds to Vangl at a highly conserved VCP-interacting motif and recruits the E3 ligase KBTBD7 via its UBA-UBX adaptors to promote Vangl ubiquitination and ER

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48

Neuhaus, Jochen, Annett Weimann, and Mandy Berndt-Paetz. "Immunocytochemical Analysis of Endogenous Frizzled-(Co-)Receptor Interactions and Rapid Wnt Pathway Activation in Mammalian Cells." International Journal of Molecular Sciences 22, no. 21 (2021): 12057. http://dx.doi.org/10.3390/ijms222112057.

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The differential activation of Wnt pathways (canonical: Wnt/β-catenin; non-canonical: planar cell polarity (PCP), Wnt/Ca2+) depends on the cell-specific availability and regulation of Wnt receptors, called Frizzled (FZD). FZDs selectively recruit co-receptors to activate various downstream effectors. We established a proximity ligation assay (PLA) for the detection of endogenous FZD–co-receptor interactions and analyzed time-dependent Wnt pathway activation in cultured cells. Prostate cancer cells (PC-3) stimulated by Wnt ligands (Wnt5A, Wnt10B) were analyzed by Cy3-PLA for the co-localization

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Feng, Bo, Andiara E. Freitas, Lilach Gorodetski та ін. "Planar cell polarity signaling components are a direct target of β-amyloid–associated degeneration of glutamatergic synapses". Science Advances 7, № 34 (2021): eabh2307. http://dx.doi.org/10.1126/sciadv.abh2307.

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The signaling pathway directly controlling the maintenance of adult glutamatergic synapses has not been well understood. Planar cell polarity (PCP) signaling components were recently shown to play essential roles in the formation of glutamatergic synapses. Here, we show that they are localized in the adult synapses and are essential for their maintenance. Synapse loss at early stages of Alzheimer’s disease is thought to be induced by β-amyloid (Aβ) pathology. We found that oligomeric Aβ binds to Celsr3 and assists Vangl2 in disassembling synapses. Moreover, a Wnt receptor and regulator of PCP

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Lojk, Jasna, and Janja Marc. "Roles of Non-Canonical Wnt Signalling Pathways in Bone Biology." International Journal of Molecular Sciences 22, no. 19 (2021): 10840. http://dx.doi.org/10.3390/ijms221910840.

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The Wnt signalling pathway is one of the central signalling pathways in bone development, homeostasis and regulation of bone mineral density. It consists of numerous Wnt ligands, receptors and co-receptors, which ensure tight spatiotemporal regulation of Wnt signalling pathway activity and thus tight regulation of bone tissue homeostasis. This enables maintenance of optimal mineral density, tissue healing and adaptation to changes in bone loading. While the role of the canonical/β-catenin Wnt signalling pathway in bone homeostasis is relatively well researched, Wnt ligands can also activate se

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