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Relevant bibliographies by topics / Wound Modulation / Dissertations / Theses

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Dissertations / Theses on the topic 'Wound Modulation'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Sharma, G. U. "Modulation of wound healing after glaucoma surgery." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1527404/.

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Glaucoma is the leading cause of irreversible blindness worldwide. Glaucoma is a progressive eye disorder characterised by atrophy of the optic nerve. In some cases, poor aqueous drainage may cause raised intraocular pressure, which causes damage to the optic nerve, leading to blindness. One of the approaches to lower intraocular pressure is to surgically create a drainage channel for the outflow of aqueous humour. Impaired wound healing and continued scarring response at the site of surgery can lead to suboptimal intraocular pressure control and eventual failure of surgery in many patients. C

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2

Javadi, Hamed H. "Stress induced modulation of edema during cutaneous wound healing." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1413364771.

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3

Muller, Michael John. "Modulation of the response to cutaneous injury /." [St. Lucia, Qld.], 2000. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16146.pdf.

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4

PITTARELLA, PAMELA. "Modulation of cell proliferation and angiogenesis for wound healing acceleration." Doctoral thesis, Università del Piemonte Orientale, 2015. http://hdl.handle.net/11579/115574.

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Wound healing is a complex process consisting of four major phases, namely haemostasis, inflammation, proliferation and tissue remodeling. Nonhealing wounds represent a significant cause of morbidity and mortality for a large portion of the population. Wound healing can be delayed by systemic factors such as age, body type and nutritional status, or by many diseases including coronary artery disease, diabetes mellitus, cancer, and vascular insufficiencies. During my PhD I have dealt with several aspects concerning the proliferative phase of the wound healing process, studying different substa

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5

Rojas-Rudolph, Isolde Gina. "Stress modulation of susceptibility to wound infection : effects on Leukocyte Trafficking and Chemokine Gene Expression during Cutaneous Wound Healing /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486474078047403.

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6

Georgoulas, Stylianos D. "Novel methods for the modulation of wound healing after glaucoma filtration surgery." Thesis, University College London (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522822.

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7

Armstrong, David James. "The role of the thrombospondins in modulation of corneal stromal wound healing." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400305.

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8

Ru, Q. "Development and investigation of implantable tablets for wound healing modulation after trabeculectomy." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1317794/.

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Modulation of wound healing is required to inhibit scar formation after trabeculectomy. Mitomycin C and 5-fluorouracil (5-FU) are the anti-proliferative drugs currently used in the clinic. Their effectiveness is limited due to their toxicity and suboptimal local tissue pharmacokinetics caused by rapid clearance within the subconjunctival space. Therefore, prolonged release of anti-scarring agents is needed. Ilomastat is a matrix metalloproteinase inhibitor that has been shown to moderate favorably the wound healing response after surgery. However, due to rapid local tissue clearance, several i

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9

Shirley, Genah, and Morbidelli Lucia. "Pharmacological modulation of endothelial function during tissue remodeling in physiopathological conditions." Doctoral thesis, Università di Siena, 2022. http://hdl.handle.net/11365/1204012.

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Vascular endothelium plays a pivotal role in the maintenance of many biological functions, including angiogenesis, defined as the formation of new capillaries from pre-existing vasculature. The process is aimed at supplying nutrients and oxygenation to growing or healing tissues following injury and, in the context of wound healing, endothelial cells lining the inner surface of blood vessels, are continuously engaged in a crosstalk with other cell types, immunity cells or fibroblasts, to assure a correct progression in the process of regeneration. Disruption of endothelial functions, which can

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10

Wiik, H. (Heikki). "Inflammatory response following abdominal surgery and its modulation by recombinant human granulocyte colony-stimulating factor (rhG-CSF, filgrastim)." Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514268474.

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Abstract The effects of perioperative filgrastim (rhG-CSF) and surgery per se on the postoperative acute phase reaction were studied by assessing leukocyte functions, cytokine levels and tenascin-C (Tn-C) and procollagen propeptide (PINP, PIIINP) concentrations in different body fluid compartments in patients undergoing gastrointestinal surgery. Thirty consecutive patients were randomized to receive either filgrastim or placebo for five days, starting 12 hours before colorectal surgery. Filgrastim treatment led to marked neutrophilia with decreased neutrophil migration in peripheral blood bu

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11

Brown, Ashley Carson. "Modulation of pulmonary epithelial to mesenchymal transitions through control of extracellular matrix microenvironments." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/44827.

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Epithelial to mesenchymal transition (EMT), the transdifferentation of an epithelial cell into a mesenchymal fibroblast, is a cellular process necessary for embryonic development and wound healing. However, uncontrolled EMT can result in accumulation of myofibroblasts and excessive deposition of ECM, contributing to the pathological progression of fibrotic diseases such as pulmonary fibrosis. The ability to control EMT is important for development of novel therapeutics for fibrotic pathologies and for designing novel biomaterials for tissue engineering applications seeking to promote EMT for

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12

MAGNAVACCA, ANDREA. "BRAZILIAN PROPOLIS: A MULTIFACETED NATURAL PRODUCT WITH HEALING PROPERTIES - A COMPREHENSIVE STUDY ON THE ABILITY TO IMPROVE CUTANEOUS WOUND HEALING THROUGH HIF-1 MODULATION." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/946269.

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La guarigione delle ferite cutanee consiste in un processo dinamico e multifasico, comprendente le quattro fasi parzialmente sovrapposte di emostasi, infiammazione, proliferazione e rimodellamento, che si innesca in risposta ad un danno e richiede l’intervento orchestrato di elementi cellulari e non per ristabilire l’integrità tissutale e l’omeostasi locale. L’esito finale della guarigione è di norma la riparazione, una forma di incompleta rigenerazione che implica fibrosi e la formazione di cicatrici la cui estensione è proporzionale alla durata e intensità della fase infiammatoria. Una preco

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13

Duchesne, Constance. "Cold-atmospheric plasma improves burn injury repair via modulation of angiogenesis, extracellular matrix formation and antibacterial effect." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLX038.

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Les brûlures thermiques affectent plusieurs millions de personnes chaque année dans le monde. Même si le taux de mortalité à diminué, la prise en charge clinique des brûlures sévères a peu évolué depuis plus de 30 ans. De plus, le traitement des grands brûlés demeure une source de séquelles physiques, pathophysiologiques et psychologiques non négligeables.Les plasmas froids (CAP) sont des gaz partiellement ionisés qui ont démontré des propriétés bioactives grâce aux espèces réactives qu’ils produisent. En effet, ils permettent d’améliorer la cicatrisation de plaie cutanée et ont des propriétés

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14

Morand, David-Nicolas. "Modulation de l'inflammation à des fins de régénération parodontale." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAJ040.

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La cicatrisation parodontale est un processus complexe, composé de quatre phases hautement intégrées (hémostase, inflammation, prolifération, remodelage), qui nécessite une interaction complexe entre les différents types tissulaires (épithélium, conjonctif, os) ainsi que la synthèse de médiateurs, tels que les hormones et les facteurs de croissance. La difficulté à pouvoir obtenir une régénération des tissus parodontaux est en partie due à la réponse inflammatoire qui interfère avec le processus de cicatrisation, via la surexpression des cytokines pro-inflammatoires, ainsi qu’à la croissance r

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15

Ghazi, Kamelia. "Etude et modulation du microenvironnement des purinorécepteurs de mort P2X7 par des formulations lipidiques et biopolymères afin de réguler les mécanismes de prolifération et de dégénérescence cellulaire sur des modèles dermatologiques : cicatrisation et mélanome." Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05P655/document.

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Le purinorécepteur P2X7 joue un rôle majeur dans les phénomènes de dégénérescences (Alzheimer, DMLA) et mort cellulaires. Récemment des études ont montré que l’activation basale de ce récepteur est indispensable dans le processus de cicatrisation et de prolifération cellulaire. Nous avons essayé de mieux comprendre le paradoxe de cette activation du récepteur P2X7 qui oriente vers la prolifération et même les métastases tumorales, mais aussi vers les mécanismes de dégénérescence cellulaire. L'influence du microenvironnement (Lipides, matrice extracellulaire, oxygène) apparait essentielle pour

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16

Francesko, Antonio. "Multifuncional biopolymer-bases materials for modulatig the activites of chromic wound enzymes." Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/113598.

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This thesis focuses on the development of active multifunctional dressing materials and nanoparticle formulations with suitable exploitation characteristics for chronic wounds treatment. Chronic wounds a growing clinical challenge in the aging and/or reduced mobility population include pressure, venous, arterial and diabetic neuropathic ulcers. Due to the nonhealing character of these ulcers their management requires an intensive medical intervention at huge healthcare costs. The prolonged inflammation and elevated concentrations of oxidative and proteolytic enzymes in all chronic wounds, impo

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17

Schuschereba, Steven Theodore. "An investigation of factors modulating wound healing after laser damage to the retina." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251783.

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18

Corbett, Melanie C. "An investigation of corneal wound healing after excimer laser surgery, and its modulating factors." Thesis, Queen Mary, University of London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301219.

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19

許慧慧 and Wai-wai Stella Hu. "Pharmacological modulation of endotoxin-induced hepatic injury in galactosamine-sensitized mice." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B31210806.

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20

Millner, Mary Angela. "Modulation of CSPG sulfation patterns through siRNA silencing of sulfotransferase expression to promote CNS regeneration." Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/24647.

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21

Sathananthan, Saranya. "Modulating fibrin matrix properties via fibrin knob peptide functionalized microgels." Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44905.

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Fibrin is the body's natural provisional matrix activated in response to vascular injury in which noncovalent knob:hole interactions between fibrin monomers lead to the assembly of fibrin for clot formation. In this study we aimed to exploit fibrin knob:hole affinity interactions with swelling, space filling microgels for the development of a potential bio-synthetic hybrid polymer system with hemostatic properties. Previous work has explored the inherent binding interactions of various fibrin knobs and their complementary polymerization holes, which have led to the development of fibrin knob p

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22

Gouzos, Michael. "A Delicate Balance: Modulation of Reactive Oxygen Species after Sinus Surgery to Improve the Healing Process." Thesis, 2020. http://hdl.handle.net/2440/130897.

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The purpose of this thesis is to examine the role of reactive oxygen species in wound healing, with respect to the paranasal sinuses and in the dual context of chronic inflammation and surgery. It goes on to explore emerging therapies that modulate reactive oxygen species and act as wound healing adjuncts. The work describes a body of translational research, utilising both in vitro and in vivo experiments aimed at improving postoperative outcomes. Focus was given to the prevention of postoperative infections and sinonasal adhesions, as these are significant issues in the realm of ENT surgery.

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23

Hung, Wei-Sheng, and 洪偉盛. "Analysis of cytotoxicity of SACCHACHITIN and its effects on local immuno-modulation and inflammation during skin wound healing." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/40113881632367129012.

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碩士<br>台北醫學院<br>細胞及分子生物研究所<br>88<br>Many biomaterials have been used in medical application and the development of biomaterials have been one of the major focusing areas of current medical research. Components of Ganoderma tsugae, “Ling-Zhi”, have been found to have various medical effects such as anti-cancer, anti-hypertension and so on. Previous studies in this research team have shown that the SACCHACHITIN made from the residue of the fruiting body of Ganoderma tsugae, as compared to cotton gauge (control group), significantly accelerates the process of rat skin wound healing. It is of gr

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24

Winardi, Wira, and Wira Winardi. "Characterization of Protein LZ-8-Induced Wound Healing Acceleration on Mouse Skin: Emphasizing in Modulation of Neutrophils, Keratinocytes, and Fibroblasts." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/08048972132305377189.

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碩士<br>臺北醫學大學<br>醫學科學研究所<br>102<br>The benefit of LZ-8 as immunomodulatory protein has been widely studied. LZ-8 reported might accelerate rat liver wound injury. However, the effect of LZ-8 on skin wound healing is less studied.This study aimed to evaluate the effectsof LZ-8 in mouse skin wound healing and determine the molecular mechanism of LZ-8-induced acceleration of wound healing.Different group of wound were generated at C57Bl/6 mice dorsal skin followed by wound histology observation. To evaluate the effect of LZ-8 for fibroblast and keratinocyte migration we performed In Vitro wound he

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25

Camões, Sérgio José Póvoas. "Modulating mesenchymal stem cells to overcome impaired wound healing." Doctoral thesis, 2020. http://hdl.handle.net/10451/48527.

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Mesenchymal stem cells (MSCs) have emerged as a promising strategy to the repair of damaged tissues, due to characteristics such as immunomodulation, anti-inflammatory properties, homing, protective and reparative effects. Additionally, MSCs have shown to exert their therapeutic activity by homing into injured tissues, cellular crosstalk and inducing tissue regeneration response through paracrine signalling, namely through exosomes. This thesis aimed to evaluate the role of the secretome (CM) and exosomes (Exo) derived from umbilical cord tissue (UC)-MSCs for damaged tissue treatment. Three-di

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26

"Towards regeneration: hyaluronan, a modulator of cutaneous wound healing." Thesis, 2009. http://library.cuhk.edu.hk/record=b6074800.

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HA (Hyaluronan, hyaluronic acid) is a predominant component of the extracellular matrix and plays diverse roles in the process of wound healing. The major significance of the biological functions of HA in wound healing arise from early studies showing that rich and prolonged existence of HA is associated with the fetal scarless wound healing. It has been hypothesized that adult wound healing can be modulated by the application of exogenous HA to make the process of wound repair more like regeneration.<br>In this thesis, the effects of molecular weight and concentration of HA on the biological

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27

Che-YuLi and 李哲瑜. "Calcium-Binding S100A2 Impaired Cutaneous Wound Healing By Modulating P53 Activity." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/25gc45.

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28

Harawa, Albert Lloyds Mtungambera. "Modulations of hybridity in Abodunrin's It would take time:." Diss., 2015. http://hdl.handle.net/10500/19997.

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In this study I identify and argue for hybridity as a common feature in four postcolonial texts, namely Femi Abodunrin’s It Would Take Time, Edward Kamau Brathwaite’s Masks, Ngugi wa Thiong’o’s Matigari and Mvona’s An Arrow from Maraka. The study advances that when two or more cultures encounter one another hybridity affects the new emergent culture socially, linguistically, historically and politically. Employing Homi Bhabha’s interrelated terms, notably ambivalence, mimicry, liminality, the third space, in-between space and interstitial space —all of which gesture towards the concept of hybr

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29

Vijaya, Raghavan Jayashree. "Improving Healing Outcomes in Diabetic Wounds by Understanding and Modulating Immune Responses." Thesis, 2022. https://etd.iisc.ac.in/handle/2005/5840.

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Diabetic Foot Ulcers (DFUs) are chronic wounds that show delayed or absence of healing in individuals with diabetes. Currently, diabetic wounds are managed clinically through regular debridement, pressure off-loading, glycemic control, and patient education. Other treatment strategies used in the clinic include topical antibiotics to prevent infections, growth factor ointments to accelerate tissue regrowth, and negative pressure therapy for drainage of wound fluid. However, such strategies have had limited success in a significant number of individuals with DFU, and the exact reasons remain un

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30

Blersch, Josephine. "BIOCOMPATIBLE NANOPARTICLES TO MODULATE CELL ACTIVITY." Doctoral thesis, 2021. http://hdl.handle.net/10316/95257.

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Tese no âmbito do Doutoramento em Biologia Experimental e Biomedicina, ramo de Biotecnologia e Saúde, apresentada ao Instituto de Investigação Interdisciplinar da Universidade de Coimbra.<br>RNA-based medicines have distinct advantages in comparison to conventional drug such as small molecules or other biomolecules in terms of specificity, potency, number of accessible targets, manufacturing, among others. However, several obstacles need to be addressed before the clinical translation of RNA-based therapeutics such as targeting and intracellular delivery. The main objective of this thesis was

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