Relevant bibliographies by topics / Zero Order Release; Lag Time

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Academic literature on the topic 'Zero Order Release; Lag Time'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Zero Order Release; Lag Time"

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Janich, Christopher, Andrea Friedmann, Juliana Martins de Souza e Silva, et al. "Risperidone-Loaded PLGA–Lipid Particles with Improved Release Kinetics: Manufacturing and Detailed Characterization by Electron Microscopy and Nano-CT." Pharmaceutics 11, no. 12 (2019): 665. http://dx.doi.org/10.3390/pharmaceutics11120665.

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For parenteral controlled drug release, the desired zero order release profile with no lag time is often difficult to achieve. To overcome the undesired lag time of the current commercial risperidone controlled release formulation, we developed PLGA–lipid microcapsules (MCs) and PLGA–lipid microgels (MGs). The lipid phase was composed of middle chain triglycerides (MCT) or isopropylmyristate (IPM). Hydroxystearic acid was used as an oleogelator. The three-dimensional inner structure of Risperidone-loaded MCs and MGs was assessed by using the invasive method of electron microscopy with focused
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Vinogradov, V. P., and E. V. Blynskaya. "Optimization of the composition and technology for the production of flotation tablets of sitagliptin with modified release." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 4 (September 6, 2024): 19–30. http://dx.doi.org/10.33920/med-13-2404-02.

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The article presents the results of the study of the influence of critical material attributes and process parameters for obtaining modified release sitagliptin floating tablets, as well as the optimization of the factor values using the surface response method and the generalized desirability function. In accordance with the three-factor three-level Box-Behnken plan, the tests of dosage forms were carried out, the values of the quality attributes - «floating lag time», the coefficient of determination of compliance with the kinetics of the zero-order release model, total release, tablet hardn
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Shaheen, Shama*¹ Eisha Ganju² Rajni Dubey³ Bhaskar Kumar Gupta⁴. "Formulation and Characterization of Sustained-Release Microspheres of Oxazepam." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 1480–87. https://doi.org/10.5281/zenodo.15202138.

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The aim of this study was to formulate and characterize oxazepam-loaded microspheres for sustained drug release to enhance its therapeutic efficacy in the treatment of anxiety and insomnia. Various formulations of microspheres were prepared using HPMC, ethyl cellulose (EC), and guar gum as polymers, and their physical properties, such as yield, drug entrapment efficiency, buoyancy, and floating lag time, were evaluated. The optimized formulation (F4) exhibited a high percentage yield (73.32±0.22%) and drug entrapment efficiency (72.23±0.32%). Furthermore, F4 showed the shortest f
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Koshta, Ashok, and Neelesh Malviya. "Formulation and Evaluation of Floating-pulsating Drug Delivery System containing Fixed-dose Combination for Chronotherapy of Hypertension." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1725–32. http://dx.doi.org/10.25258/ijddt.12.4.39.

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This project aims to build a floating, pulsatile hypertension therapy. This work examined the 3-factor, 2-level box-behnken design and optimization technique for the floating pulsatile tablet. The quantity of polyox WSR N12K and polyox WSR205 was chosen to be the independent variable. Drug release, lag time, and swelling index are chosen to function in terms of dependent variables. ANOVA was intended to assess the data statistically, and p-value of 0.05 was regarded to have statistical significance. The tablet containing bisoprolol fumarate (BF) and hydrochlorothiazide (HCTZ) was chosen for pr
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Dolas, Ramdas T., Shalindra Sharma, and Madhuraj Sharma. "FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF LAFUTIDINE." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 393–99. http://dx.doi.org/10.22270/jddt.v8i5.1898.

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The purpose of this research was to develop a novel gastroretentive drug delivery system based on wet granulation technique for sustained delivery of active agent. Quick GI transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to decreased efficacy of the administered dose and thus less patient compliance. Gastroretentive floating tablets, which was designed to provide the desired sustained and complete release of drug for prolonged period of time. Gastroretentive floating tablets of lafutidine were prepared by wet granulation technique
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Patel, Upasana J., Hitesh kumar A. Patel, Bhumika J. Limbachiya, and Mehzabeen Jhankhwala. "Formulation, development and optimization of gastroretentive floating pellets of febuxostat." Journal of medical pharmaceutical and allied sciences 11, no. 1 (2022): 4317–23. http://dx.doi.org/10.55522/jmpas.v11i1.2095.

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The aim of the study was to develop gastro retentive floating pellets of febuxostat used to treat gout condition which having low solubility and high bioavailability. The gastro retentive floating pellets of febuxostat were formulated using Gelucire 43/01 and ethyl cellulose as a sustain release polymer and microcrystalline cellulose as spheronizing agent by extrusion- spheronization technique. A 32 full factorial design was applied to investigate the effect of the two-independent variable, that is, ratio of Drug: Gelucire (X1) and ratio of Drug: ethyl cellulose (X2), on the dependent variable
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Jaiseri, Dareena, Supusson Pengnam, Praneet Opanasopit, et al. "Novel propranolol-loaded gastro-floating 3D-printed devices with zero-order release kinetics." Pharmacia 71 (December 19, 2024): 1–8. https://doi.org/10.3897/pharmacia.71.e133399.

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Currently, fused deposition modeling (FDM) is a 3D printing technology that has been most widely used to develop innovative drug delivery approaches for overcoming the limitations of oral drug administration. Propranolol has a short plasma half-life and is well soluble in acidic environments. Thus, this study aimed to develop a gastro-floating 3D printed device (GFD) to sustain the release of propranolol in the stomach as a gastro-retentive drug delivery system. The polylactic acid (PLA) was selected to fabricate the GFD. An air chamber was included in the interior construction of the GFD desi
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Jaiseri, Dareena, Supusson Pengnam, Praneet Opanasopit, et al. "Novel propranolol-loaded gastro-floating 3D-printed devices with zero-order release kinetics." Pharmacia 71 (December 19, 2024): 1–8. https://doi.org/10.3897/pharmacia.71.e133399.

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Currently, fused deposition modeling (FDM) is a 3D printing technology that has been most widely used to develop innovative drug delivery approaches for overcoming the limitations of oral drug administration. Propranolol has a short plasma half-life and is well soluble in acidic environments. Thus, this study aimed to develop a gastro-floating 3D printed device (GFD) to sustain the release of propranolol in the stomach as a gastro-retentive drug delivery system. The polylactic acid (PLA) was selected to fabricate the GFD. An air chamber was included in the interior construction of the GFD desi
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Shiv, Sagar Mahapatra*1 Akanksha Patel2 Manmath Purohit3. "Design Development And Evaluation Of Floating Drug Delivery System For Lornoxicam NSAID Drug." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 231–51. https://doi.org/10.5281/zenodo.10927489.

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Lornoxicam is one of the drugs used for the management of arthritic pain. The site of absorption of Lornoxicam is in the GIT and it has a short half life of 3-4 h. Therefore, the present investigation was concerned with the development of the floating matrix tablets, which after oral administration are designed to prolong the gastric residence time and thus, improve the bioavailability of the drug as well as its half life. Lornoxicam showed maximum absorption at wavelength at 374 nm in 0.1 N HCl. Drug-Polymer compatibility studies by FTIR gave conformation about their purity and showed no inte
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Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.

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Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4,
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Book chapters on the topic "Zero Order Release; Lag Time"

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Sunitha, Ramineni, Praveen Sivadasu, and Raghavendra Kumar Gund. "Statistical Optimization and Evaluation of Extended Release Tablets for Divalproex Sodium." In Current Trends in Drug Discovery, Development and Delivery (CTD4-2022). Royal Society of Chemistry, 2023. http://dx.doi.org/10.1039/9781837671090-00549.

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The purpose of current experimental research is to optimize the quantities of macromolecules such as EudragitL/100-55, HPMC-K-100M for the development of divalproex sodium extended release tablets. Divalproexsodium, an anticonvulsant or epileptic agent. It was used in the effective management of bipolar disorders, Mania, seizures, convulsions, tremors/epilepsy. Divalproex sodium ER tablets were formulated with the help of EudragitL/100-55 and HPMC-K-100M in variable composition and variable amounts as per 32 factorial design technique. They were prepared by direct compression technique. Quanti
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Meda, Raviteja. "Designing circular supply chains and eco-conscious infrastructure for sustainable manufacturing." In Intelligent Industry Ecosystems and Manufacturing Renaissance: Designing Autonomous Production, Supply Orchestration, and Connected Retail Infrastructure. Deep Science Publishing, 2025. https://doi.org/10.70593/978-93-49910-35-5_9.

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In order to obtain a sustainable form of living on Earth, it is absolutely necessary to achieve Nets Zero Production Waste in Manufacturing, defined as the waste managing and disposal to landfills, the release to Air or Water Pollution, the waste exporting or transferring to other nations, etc. This goal cannot be achieved only with cleaning and recycling technologies, because the cost of cleaning wastes and transforming them into something useful is equal or more than their energetic, financial, or ecological cost. The progress towards a Nets Zero Waste for Manufacturing is a true revolution
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Conterio, Martyn. "Metal Damage, Brain Damage." In Mad Max. Liverpool University Press, 2020. http://dx.doi.org/10.3828/liverpool/9781911325864.003.0003.

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This chapter traces the history of Australian film production in order to examine how George Miller came to make his first film and how a resurgent Australian film industry helped Mad Max (1979) into being. Australian film production was in serious trouble after the Second World War. Even earlier, like other countries after the First World War, it had had to contend with the raging popularity of American movies. From the late 1960s, where film output was virtually zero, to around 20 films a year in the late 1970s, the Australian New Wave was no mad gold rush, but did enough to bear fruit. It b
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Singh, Prabhakar, Sudhakar Singh, and Rajesh Kumar Kesharwani. "Resealed Erythrocytes as Drug Carriers and Its Therapeutic Applications." In Pharmaceutical Sciences. IGI Global, 2017. http://dx.doi.org/10.4018/978-1-5225-1762-7.ch018.

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In this pharma innovative world, there are more than 30 drug delivery systems. Today's due to lacking the target specificity, the present scenario about drug delivery is emphasizing towards targeted drug delivery systems. Erythrocytes are the most common type of blood cells travel thousands of miles from wide to narrow pathways to deliver oxygen, drugs and nutrient during their lifetime. Red blood cells have strong and targeted potential carrier capabilities for varieties of drugs. Drug-loaded carrier erythrocytes or resealed erythrocytes are promising for various passive and active targeting.
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Heggland, Roar. "Using Gas Chimneys in Seal Integrity Analysis." In Evaluating Fault and Cap Rock Seals. American Association of Petroleum Geologists, 2005. https://doi.org/10.1306/1060767h23170.

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Abstract Gas chimneys are visible in seismic data as columnar disturbances, where the continuity of reflectors is missing, and reflection amplitudes are weaker than in the surrounding areas. In this chapter, gas chimneys interpreted from threedimensional seismic data, some of which have been confirmed by wells, have been sorted into two kinds. Type 1 chimneys are associated with faults. These chimneys commonly have a circular and limited horizontal cross section with a diameter in the order of 100 m (330 ft). The presence of gas chimneys along faults indicates that the faults are open or have
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Conference papers on the topic "Zero Order Release; Lag Time"

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Xu, Jia. "Pre-Run-Time Scheduling of Asynchronous and Periodic Processes With Offsets, Release Times, Deadlines, Precedence and Exclusion Relations." In ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2009. http://dx.doi.org/10.1115/detc2009-87769.

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Utilizing non-zero offsets when scheduling real-time periodic processes significantly increases the chances of satisfying all the timing constraints in a real-time system. In this paper, a method that enables the utilization of non-zero offsets in the pre-run-time scheduling of asynchronous and periodic processes with release times, deadlines, precedence and exclusion relations on either a uniprocessor or on a multiprocessor in real-time embedded systems is presented. This paper also identifies for the first time, the set of general conditions that a periodic process newpi with release time rn
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Stefanopoulou, Anna G., and Ilya Kolmanovsky. "Dynamic Scheduling of Internal Exhaust Gas Recirculation Systems." In ASME 1997 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 1997. http://dx.doi.org/10.1115/imece1997-0455.

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Abstract In this paper we analyze the nonlinear dynamic behavior of an internal exhaust gas recirculation system based on the mean-value model of an experimental engine equipped with a camshaft phaser. We develop a dynamic camshaft timing schedule that regulates the internal exhaust gas recirculation system while maintaining transient engine torque response similar to an engine with zero exhaust gas recirculation. The dynamic schedule consists of a steady-state map of the camshaft timing for optimum exhaust gas recirculation based on throttle position and engine speed, and a first order lag th
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Steele, Robert C., Luke H. Cowell, Steven M. Cannon, and Clifford E. Smith. "Passive Control of Combustion Instability in Lean Premixed Combustors." In ASME 1999 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/99-gt-052.

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A Solar fuel injector that provides lean premixed combustion conditions has been studied in a combined experimental and numerical investigation. Lean premixed conditions can be accompanied by excessive combustion driven pressure oscillations which must be eliminated before the release of a final combustor design. In order to eliminate the pressure oscillations the location of fuel injection was parametrically evaluated to determine a stable configuration. It was observed that small axial changes in the position of the fuel spokes within the premix duct of the fuel injector had a significant po
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PATTON, EVAN G., and ROBERT J. HART. "DEFLECTION-TIME CHARACTERIZATION ON HIGH- PRESSURE IMPACTED THERMOPLASTIC-METAL HYBRID PANELS." In Proceedings for the American Society for Composites-Thirty Seventh Technical Conference. Destech Publications, Inc., 2022. http://dx.doi.org/10.12783/asc37/36477.

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High strain rate events pose high levels of complexity when analyzing a materials deformation characteristics. In high strain rate events like blast and impact, understanding the damage progression within the tested material is crucial when optimizing material design to give a desired performance. Under extreme loading cases inertial effects play a large role on how a material system performs. When a structure is blast loaded and begins deformation, inertial effects cause the structure to continue to deform past its stressed equilibrium point even after the main front of the shock wave has pas
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Schuermans, Bruno B. H., Wolfgang Polifke, and Christian Oliver Paschereit. "Modeling Transfer Matrices of Premixed Flames and Comparison With Experimental Results." In ASME 1999 International Gas Turbine and Aeroengine Congress and Exhibition. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/99-gt-132.

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A combined analytical/experimental investigation of the thermoacoustic properties of a gas turbine burner with a premixed, turbulent, swirl-stabilized flame is presented. In an enclosed flame, an interaction occurs between acoustic fluctuations and non-steady heat release, which may lead to thermoacoustic instabilities. This interaction may be characterized by the transfer matrix of the burner with flame. The transfer matrix describes the coupling between fluctuations of acoustic pressure and velocity on both sides of burner and flame, incorporating also the effects of heat release fluctuation
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Grattoni, Alessandro, Xuewu Liu, Zongxing Wang, Jaskaran Gill, Arturas Ziemys, and Mauro Ferrari. "Electrokinetic Transport of Molecules Through Nanochanneled Membranes." In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13236.

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Our research group was the first one to microfabricate and demonstrate nano-channels in silicon membranes (1, 2). We employed nano-channeled chips to provide immuno-isolation for cell transplantation towards the treatment of diabetes (3), for biomolecular separation (4), and for the controlled passive and active release of drug molecules from implanted capsules (5). We showed that the constraints placed upon molecular agitation in nano-channels affected their concentration-driven transport kinetics (6, 7). A zero-order passive release of biological molecules was achieved, by the rational tailo
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Armitage, C. A., R. S. Cant, A. P. Dowling, and T. P. Hynes. "Linearised Theory for LPP Combustion Dynamics." In ASME Turbo Expo 2003, collocated with the 2003 International Joint Power Generation Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/gt2003-38670.

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Gas turbines which are operated under lean, premixed, pre–vaporised (LPP) conditions are notoriously susceptible to self–excited oscillations. In the combustion chamber the unsteady heat released by combustion processes interacts with pressure fluctuations. The challenge is to develop a tool which can determine the frequency and stability characteristics of self–excited oscillations in realistic gas–turbine geometries. To this end, the flow through the gas turbine is described as far as possible by taking advantage of linearised theory and analytical models of the behaviour in the combustion c
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Ponti, Fabrizio, Vittorio Ravaglioli, and Matteo De Cesare. "Development of a Common Rail Diesel Engine Combustion Model for ROHR Real-Time Estimation." In ASME 2011 Internal Combustion Engine Division Fall Technical Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/icef2011-60153.

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Combustion control is a crucial aspect in modern Diesel engines control strategies, mainly due to the requests to increase efficiency and maintain pollutant emissions within the values bounded by standard regulations. In order to perform an accurate combustion control, modern “closed loop” control algorithms require the evaluation of a large number of quantities that provide information about combustion process effectiveness. This work presents a methodology that allows real-time estimation of energy released, during the combustion process, in a Common Rail Multi-Jet Diesel engine. This proced
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Laino, David J., and A. Craig Hansen. "Continued Validation of the AeroDyn Subroutines Using NREL Unsteady Aerodynamics Experiment Data." In ASME 2003 Wind Energy Symposium. ASMEDC, 2003. http://dx.doi.org/10.1115/wind2003-518.

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Full-scale wind tunnel tests of the NREL Unsteady Aerodynamics Experiment (UAE) Phase VI permitted unprecedented control and measurement of inflow to the UAE rotor. This in turn has allowed in-depth validation of the AeroDyn wind turbine aerodynamics software. This validation began with comparison of simple cases (i.e., fixed yaw, fixed pitch, no teeter), with results presented last year [2]. Among the findings of that study was the significant increase in section lift along the rotor blades due to the 3–dimensional flow over the UAE rotor. This delayed stall was not adequately accounted for i
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Williams, Gareth. "Contribution of the Keynote Speaker - Novel Nanotechnologies for New Medicines." In SLIIT INTERNATIONAL CONFERENCE ON ADVANCEMENTS IN SCIENCES AND HUMANITIES. Faculty of Humanities & Sciences, SLIIT, 2024. https://doi.org/10.54389/webi4830.

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In order to be effective, a drug must be delivered to the right part of the body, at the correct time, and in an appropriate amount. If any one of these three criteria is not met, then a medicine will be ineffective or even dangerous. To develop potent medicines, pharmaceutical scientists need to find ways to enhance the intrinsic properties of drug molecules, for instance by increasing their solubility in water. There are a number of technologies which have been adopted to achieve these goals. One emerging approach which is attracting significant interest is electrospinning, which applies an
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