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Journal articles on the topic 'Acridine – Synthèse'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Ngadi, Léon, Pierre Brouant, Anne-Marie Galy, Jean-Pierre Galy, Jean-Claude Soyfer, and Jacques Barbe. "Synthèse et dipolemétrie de quelques acridine-9-ones et acridine-9-thiones substituées en position 1." European Journal of Medicinal Chemistry 25, no. 1 (1990): 21–28. http://dx.doi.org/10.1016/0223-5234(90)90160-5.

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2

Gabriel, Iwona. "‘Acridines’ as New Horizons in Antifungal Treatment." Molecules 25, no. 7 (2020): 1480. http://dx.doi.org/10.3390/molecules25071480.

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Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide. The repertoire of antifungal chemotherapeutic agents is very limited. Although new antifungal drugs such as lanosterol 14α-demethylase and β-glucan synthase inhibitors have been introduced into clinical practice, the development of multidrug resistance has become increasingly significant. The urgency to expand the range of therapeutic options for the treatment of f

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3

Llama, E. "Synthèse et activité antinociceptive de dérivés phényl-9-alkoxy-9 ou acyl-oxy-9 de xanthène, thioxanthène et acridine." European Journal of Medicinal Chemistry 24, no. 4 (1989): 391–96. http://dx.doi.org/10.1016/0223-5234(89)90083-4.

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4

Amiel, Pascale, Abdallah Mahamoud, Pierre Brouant, et al. "Tautomérie du 2,5-dimercapto-1,3,4-thiadiazole et synthèse de thiadiazoloacridiniques." Canadian Journal of Chemistry 73, no. 8 (1995): 1258–66. http://dx.doi.org/10.1139/v95-154.

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Some 2(3H)-thione-5-alkylthio-1,3,4-thiadiazoles were prepared with a view to arylating these compounds with 9-chloroacridines. Using pyridine as solvent and base, this arylation led to the 2-thione-(N)3-acridinyl-5-alkylthio-1,3,4-thiadiazoles. Molecular structures of the latter were determined either by NMR spectroscopy or by referring to X-ray crystallography of the 5-(diethylaminoethylthio)-1,3,4-thiadiazole-2-thione. Thus, with respect to the tautomeric equilibrium of the compound investigated, the thione group was detected either in the solid state or in solution. In contrast, 2-acridiny

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5

Lukačin, Richard, Stephan Schreiner, and Ulrich Matern. "Transformation of acridone synthase to chalcone synthase." FEBS Letters 508, no. 3 (2001): 413–17. http://dx.doi.org/10.1016/s0014-5793(01)03061-7.

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6

Gröger, D., A. Baumert, and W. Maier. "Acridone Synthase: A Key Enzyme in Acridone Alkaloid Biosynthesis." Planta Medica 59, S 1 (1993): A584—A585. http://dx.doi.org/10.1055/s-2006-959783.

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7

Hoffmann, Siegfried, Regina Skölziger, and Werner Witkowski. "Synthese bisbasisch-substituierter Acridine als potentielle Nucleinsäureeffektoren." Zeitschrift für Chemie 26, no. 9 (2010): 331–32. http://dx.doi.org/10.1002/zfch.19860260907.

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8

Baumert, Alfred, Walter Maier, Detlef Gröger, and Rainer Deutzmann. "Purification and Properties of Acridone Synthase from Cell Suspension Cultures of Ruta gvaveolens L." Zeitschrift für Naturforschung C 49, no. 1-2 (1994): 26–32. http://dx.doi.org/10.1515/znc-1994-1-205.

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Acridone synthase has been purified from cell suspension cultures of Ruta graveolens using a combination of gel filtration and ion exchange chromatography. The purified enzyme has an apparent molecular weight of 69 kDa on gel filtration and a subunit structure on SDS-PAGE of 40 kDa. The apparent Km-values are 10.64 μM and 32.8 μM for N-methylanthraniloyl-CoA and malonyl-CoA, respectively. Tryptic digestion of the homogeneous acridone synthase was performed. Seven of the peptides were chosen for microsequencing. The homology of the amino acid sequences from this particular polypeptide and corre

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9

Bender, Matthias, and Jens Christoffers. "Investigations into the Regioselectivity of Fischer Indole and Friedländer Quinoline Syntheses with Octahydroisobenzofuran and Octahydroisoindole Derivatives." Zeitschrift für Naturforschung B 66, no. 12 (2011): 1209–18. http://dx.doi.org/10.1515/znb-2011-1203.

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A Fischer indole synthesis with a cis-configurated octahydroisobenzofuran-6-one yielded exclusively a furo[3,4-c]carbazole derivative as the product of a regioselective angular annulation reaction. A Friedländer quinoline synthesis from the same substrate gave a mixture of angular and linear annulation products, i. e. furo[3,4-a]acridine and furo[3,4-b]acridine derivatives. When submitting a mixture of cis- and trans-octahydroisoindole derivatives to Fischer and Friedländer syntheses, the trans-starting material gave regioselectively linear annulation products, i. e. pyrrolo[3,4-b]carbazole an

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10

Nishibori, Ayako, Jin Kusaka, Hiroshi Hara, Masato Umeda, and Kouji Matsumoto. "Phosphatidylethanolamine Domains and Localization of Phospholipid Synthases in Bacillus subtilis Membranes." Journal of Bacteriology 187, no. 6 (2005): 2163–74. http://dx.doi.org/10.1128/jb.187.6.2163-2174.2005.

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ABSTRACT Application of the cardiolipin (CL)-specific fluorescent dye 10-N-nonyl-acridine orange has recently revealed CL-rich domains in the septal regions and at the poles of the Bacillus subtilis membrane (F. Kawai, M. Shoda, R. Harashima, Y. Sadaie, H. Hara, and K. Matsumoto, J. Bacteriol. 186:1475-1483, 2004). This finding prompted us to examine the localization of another phospholipid, phosphatidylethanolamine (PE), with the cyclic peptide probe, Ro09-0198 (Ro), that binds specifically to PE. Treatment with biotinylated Ro followed by tetramethyl rhodamine-conjugated streptavidin reveale

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11

Lukačin, Richard, Stephan Schreiner, and Ulrich Matern. "Corrigendum to: Transformation of acridone synthase to chalcone synthase (FEBS 25452)." FEBS Letters 510, no. 1-2 (2001): 108. http://dx.doi.org/10.1016/s0014-5793(01)03245-8.

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12

Gupta, Tanu, Jay Bahadur Singh, Kalpana Mishra, and Radhey M. Singh. "Active methylene compounds (AMCs) controlled facile synthesis of acridine and phenanthridine from morita Baylis–Hillman acetate." RSC Advances 7, no. 86 (2017): 54581–85. http://dx.doi.org/10.1039/c7ra09447g.

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13

Süße, Manfred, and Siegfried Johne. "Eine neue Synthese von 1,2,3,4,9,10-Hexahydro-acridin-1,9-dionen." Zeitschrift für Chemie 25, no. 12 (2010): 432. http://dx.doi.org/10.1002/zfch.19850251207.

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14

Boyer, Gérard, Jean-Pierre Galy, and Jacques Barbe. "Synthèse et caractérisation de bis acridines pontées en positions 2, 3 ou 4." Journal of Heterocyclic Chemistry 28, no. 4 (1991): 913–18. http://dx.doi.org/10.1002/jhet.5570280413.

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15

Wanibuchi, Kiyofumi, Ping Zhang, Tsuyoshi Abe, et al. "An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata." FEBS Journal 274, no. 4 (2007): 1073–82. http://dx.doi.org/10.1111/j.1742-4658.2007.05656.x.

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16

Chen, QP, and LW Deady. "Synthesis of Some Benzo[b][1,6]naphthyridines and Benzo[b][1,7]naphthyridines." Australian Journal of Chemistry 46, no. 7 (1993): 987. http://dx.doi.org/10.1071/ch9930987.

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Pfitzinger (1-benzylpiperidin-4-one with 7-methylisatin) and Friedlander (3-aminopyridine-4-carbaldehyde with 2-methylcyclohexanone) syntheses, respectively, were used to prepare the title 'azaacridines' containing a methyl substituent peri to the central nitrogen. Oxidation of this group gave the corresponding aldehyde and carboxylic acid. In the [1,6] case, especially, the 10-position was also easily oxidized to give acridone analogues. Nitration occurred exclusively in the benzenoid rings.

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17

Springob, Karin, Richard Lukačin, Claudia Ernwein, Inga Gröning, and Ulrich Matern. "Specificities of functionally expressed chalcone and acridone synthases from Ruta graveolens." European Journal of Biochemistry 267, no. 22 (2000): 6552–59. http://dx.doi.org/10.1046/j.1432-1327.2000.01746.x.

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18

Lukačin, Richard, Karin Springob, Claus Urbanke, et al. "Native acridone synthases I and II from Ruta graveolens L. form homodimers." FEBS Letters 448, no. 1 (1999): 135–40. http://dx.doi.org/10.1016/s0014-5793(99)00355-5.

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19

Poulallion, Pierre, Jean-Pierre Galy, Emile-Jean Vincent, Anne-Marie Galy, Jacques Barbe та Ghanem Atassi. "Synthèse et caractérisation d'une série de bis-9,9′(thio-9-acridinyl)-α,ω-alcanes". Journal of Heterocyclic Chemistry 23, № 4 (1986): 1141–49. http://dx.doi.org/10.1002/jhet.5570230436.

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20

Han, Jie, Chaoyang Huang, Jiukun Jiang, and Dongmei Jiang. "Activation of autophagy during farnesyl pyrophosphate synthase inhibition is mediated through PI3K/AKT/mTOR signaling." Journal of International Medical Research 48, no. 4 (2019): 030006051987537. http://dx.doi.org/10.1177/0300060519875371.

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Objectives Autophagy is divided into three phases: autophagosome engulfment of intracellular organelles and proteins, autophagosome fusion with lysosomes, and autolysosome degradation. The farnesyl pyrophosphate synthase inhibitor ibandronate (IBAN) has in vivo cardioprotective properties, potentially via anti-oxidant effects. Whether autophagy is involved in the cardioprotective effect of IBAN remains unexplored. Methods Human umbilical vein endothelial cells (HUVECs) were treated in vitro with IBAN to assess autophagy induction. Lysosomal activation and phosphatidylinositol 3-kinase (PI3K)/p

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21

Junghanns, Kay Teja, Richard Edward Kneusel, Alfred Baumert, Walter Maier, Detlef Gr�ger, and Ulrich Matern. "Molecular cloning and heterologous expression of acridone synthase from elicited Ruta graveolens L. cell suspension cultures." Plant Molecular Biology 27, no. 4 (1995): 681–92. http://dx.doi.org/10.1007/bf00020222.

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22

Hsing, Chung-Hsi, Yu-Hong Chen, Chia-Ling Chen та ін. "Anesthetic Propofol Causes Glycogen Synthase Kinase-3β-regulated Lysosomal/Mitochondrial Apoptosis in Macrophages". Anesthesiology 116, № 4 (2012): 868–81. http://dx.doi.org/10.1097/aln.0b013e31824af68a.

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Background Overdose propofol treatment with a prolong time causes injury to multiple cell types; however, its molecular mechanisms remain unclear. Activation of glycogen synthase kinase (GSK)-3β is proapoptotic under death stimuli. The authors therefore hypothesize that propofol overdose induces macrophage apoptosis through GSK-3β. Methods Phagocytic analysis by uptake of Staphylococcus aureus showed the effects of propofol overdose on murine macrophages RAW264.7 and BV2 and primary human neutrophils in vitro. The authors further investigated cell apoptosis in vitro and in vivo, lysosomal memb

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23

Morita, Hiroyuki, Shin Kondo, Ryohei Kato, et al. "Crystallization and preliminary crystallographic analysis of an acridone-producing novel multifunctional type III polyketide synthase fromHuperzia serrata." Acta Crystallographica Section F Structural Biology and Crystallization Communications 63, no. 7 (2007): 576–78. http://dx.doi.org/10.1107/s1744309107026164.

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24

Mori, Takahiro, Yoshihiko Shimokawa, Takashi Matsui, et al. "Cloning and Structure-Function Analyses of Quinolone- and Acridone-producing Novel Type III Polyketide Synthases fromCitrus microcarpa." Journal of Biological Chemistry 288, no. 40 (2013): 28845–58. http://dx.doi.org/10.1074/jbc.m113.493155.

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25

Palumbo, Paola, Francesca Lombardi, Francesca Rosaria Augello, et al. "NOS2 inhibitor 1400W Induces Autophagic Flux and Influences Extracellular Vesicle Profile in Human Glioblastoma U87MG Cell Line." International Journal of Molecular Sciences 20, no. 12 (2019): 3010. http://dx.doi.org/10.3390/ijms20123010.

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The relevance of nitric oxide synthase 2 (NOS2) as a prognostic factor in Glioblastoma Multiforme (GBM) malignancy is emerging. We analyzed the effect of NOS2 inhibitor 1400W on the autophagic flux and extracellular vesicle (EV) secretion in U87MG glioma cells. The effects of glioma stem cells (GSC)-derived EVs on adherent U87MG were evaluated. Cell proliferation and migration were examined while using Cell Counting Kit-8 assay (CCK-8) and scratch wound healing assay. Cell cycle profile and apoptosis were analyzed by flow cytometry. Autophagy-associated acidic vesicular organelles were detecte

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26

Junghanns, Kay T., Richard E. Kneusel, Detlef Gröger§, and Ulrich Matern. "Differential regulation and distribution of Acridone Synthase in Ruta graveolens in honour of Professor G. H. Neil Towers 75th birthday." Phytochemistry 49, no. 2 (1998): 403–11. http://dx.doi.org/10.1016/s0031-9422(98)00104-6.

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27

Nguyen, April, Vinathi Polamraju, Truc T. Tran, et al. "1446. Dynamics of Enterococcus faecalis Cardiolipin Synthase Gene Expression Reveal Compensatory Roles in Daptomycin Resistance." Open Forum Infectious Diseases 7, Supplement_1 (2020): S726. http://dx.doi.org/10.1093/ofid/ofaa439.1627.

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Abstract Background Daptomycin (DAP) is a lipopeptide antibiotic targeting membrane anionic phospholipids (APLs) at the division septum, and resistance (DAP-R) has been linked to mutations in genes encoding i) the LiaFSR stress response system or its effector LiaX, and ii) cardiolipin synthase (Cls). Activation of the E. faecalis (Efs) LiaFSR response is associated with DAP-R and redistribution of APL microdomains away from the septum, and cardiolipin is predicted to be a major component of these APL microdomains. Efs harbors two putative cls genes, cls1 and cls2. While changes in Cls1 have be

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28

Khade, Amol B., Sidhartha S. Kar, Cinu T. Alummoottil, et al. "Synthesis, Biological Evaluation and Molecular Dynamics Simulation Studies of Novel Diphenyl Ethers." Medicinal Chemistry 16, no. 2 (2020): 256–70. http://dx.doi.org/10.2174/1573406415666190306152907.

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Background: The well-known antibacterial agent Triclosan (TCL) that targets bacterial enoylacyl protein reductase has been described to inhibit human fatty acid synthase (FASN) via the enoylacyl reductase domain. A Literature survey indicates that TCL is selectively toxic to cancer cells and furthermore might indeed reduce cancer incidence in vivo. A recent study found that TCL inhibits FASN by acting as an allosteric protein-protein interface (PPI) inhibitor. It induces dimer orientation changes that effect in a downstream reorientation of catalytic residues in the NADPH binding site proposin

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29

Kawai, Fumitaka, Momoko Shoda, Rie Harashima, Yoshito Sadaie, Hiroshi Hara, and Kouji Matsumoto. "Cardiolipin Domains in Bacillus subtilis Marburg Membranes." Journal of Bacteriology 186, no. 5 (2004): 1475–83. http://dx.doi.org/10.1128/jb.186.5.1475-1483.2004.

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ABSTRACT Recently, use of the cardiolipin (CL)-specific fluorescent dye 10-N-nonyl-acridine orange (NAO) revealed CL-rich domains in the Escherichia coli membrane (E. Mileykovskaya and W. Dowhan, J. Bacteriol. 182: 1172-1175, 2000). Staining of Bacillus subtilis cells with NAO showed that there were green fluorescence domains in the septal regions and at the poles. These fluorescence domains were scarcely detectable in exponentially growing cells of the clsA-disrupted mutant lacking detectable CL. In sporulating cells with a wild-type lipid composition, fluorescence domains were observed in th

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30

Jakob, N. J., R. G. Kleespies, C. A. Tidona, K. Müller, H. R. Gelderblom, and G. Darai. "Comparative analysis of the genome and host range characteristics of two insect iridoviruses: Chilo iridescent virus and a cricket iridovirus isolate." Journal of General Virology 83, no. 2 (2002): 463–70. http://dx.doi.org/10.1099/0022-1317-83-2-463.

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The iridovirus isolate termed cricket iridovirus (CrIV) was isolated in 1996 from Gryllus campestris L. and Acheta domesticus L. (both Orthoptera, Gryllidae). CrIV DNA shows distinct DNA restriction patterns different from those known for Insect iridescent virus type 6 (IIV-6). This observation led to the assumption that CrIV might be a new species within the family Iridoviridae. CrIV can be transmitted perorally to orthopteran species, resulting in specific, fatal diseases. These species include Gryllus bimaculatus L. and the African migratory locust Locusta migratoria migratorioides (Orthopt

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31

Nguyen, April, Truc T. Tran, Diana Panesso, et al. "602. Mechanism of LiaY-Mediated Daptomycin Resistance in Enterococcus faecalis." Open Forum Infectious Diseases 6, Supplement_2 (2019): S282. http://dx.doi.org/10.1093/ofid/ofz360.671.

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Abstract Background Daptomycin (DAP) is a lipopeptide antibiotic that targets the cell membrane (CM) at the division septum. DAP resistance (DAP-R) in E. faecalis (Efs) has been linked to mutations in genes encoding the LiaFSR stress response system and lipid biosynthetic enzymes, including cardiolipin synthase (Cls). The signature phenotype of DAP-R is redistribution of CM anionic phospholipid (APL) microdomains. Using a genetic approach, we have identified a transmembrane protein (LiaY) as a major mediator of cell membrane APL redistribution associated with DAP-R. Here, we explore the mechan

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32

Kerbs, Anastasia, Melanie Mindt, Lynn Schwardmann, and Volker F. Wendisch. "Sustainable Production of N-methylphenylalanine by Reductive Methylamination of Phenylpyruvate Using Engineered Corynebacterium glutamicum." Microorganisms 9, no. 4 (2021): 824. http://dx.doi.org/10.3390/microorganisms9040824.

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N-alkylated amino acids occur widely in nature and can also be found in bioactive secondary metabolites such as the glycopeptide antibiotic vancomycin and the immunosuppressant cyclosporine A. To meet the demand for N-alkylated amino acids, they are currently produced chemically; however, these approaches often lack enantiopurity, show low product yields and require toxic reagents. Fermentative routes to N-alkylated amino acids like N-methyl-l-alanine or N-methylantranilate, a precursor of acridone alkaloids, have been established using engineered Corynebacterium glutamicum, which has been use

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33

Born, Ella J., Sara V. Hollins, and Sarah A. Holstein. "Evaluation of Autophagy Modulators and Isoprenoid Biosynthetic Pathway Inhibitors in Multiple Myeloma Cells." Blood 118, no. 21 (2011): 2488. http://dx.doi.org/10.1182/blood.v118.21.2488.2488.

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Abstract Abstract 2488 The production of monoclonal protein (MP) by malignant plasma cells is a hallmark of multiple myeloma (MM). We have previously demonstrated that select inhibitors of the isoprenoid biosynthetic pathway (IBP) which diminish Rab geranylgeranylation, disrupt MP trafficking in MM cells. The resulting intracellular accumulation of MP leads to induction of the unfolded protein response (UPR) pathway and apoptosis. The proteasome-mediated ER-associated degradation pathway has been shown to play an important role in intracellular degradation of monoclonal protein. Autophagy, ano

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34

Choi, Gyu-Sik, Hye Jeong Choo, Bong-Gyu Kim, and Joong-Hoon Ahn. "Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli." Microbial Cell Factories 19, no. 1 (2020). http://dx.doi.org/10.1186/s12934-020-01331-2.

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