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Dissertations / Theses on the topic 'Amodiaquine'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Clarke, Janet Barbara. "Immunogenicity and antigenicity of amodiaquine." Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316558.

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2

Winstanley, Peter Andrew. "The pharmacology and toxicology of amodiaquine." Thesis, University of Liverpool, 1988. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.237571.

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3

Jewell, Hayley. "The role of metabolism in the toxicity of amodiaquine." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240477.

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4

Benaphtali, Pascale. "Rôle de la phase hépatique dans la toxicité de deux antimalariques : l'amodiaquine et la primaquine." Paris 5, 1993. http://www.theses.fr/1993PA05P105.

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5

Hough, Sally Jane. "Development of animal models to investigate drug-induced toxicity." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266265.

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6

Meyer, Gilles. "Hepatites aigues a l'amodiaquine : a propos d'un cas et revue de la litterature." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M047.

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7

Paunescu, Emilia. "Design, synthèse, analyse structurale et activité antipaludique des nouveaux analogues de l'amodiaquine et l'amopyroquine." Lille 2, 2007. http://www.theses.fr/2007LIL2S013.

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Une première direction de recherche a été centrée sur la conception, synthèse, analyse structurale et activité antipaludique de nouveaux analogues de l'amodiaquine et de l'amopyroquine. Après une introduction sur le paludisme, les mécanismes d'action des médicaments de la famille des 4-aminoquinoléiques, la structure et les propriétés thérapeutiques de ces composés, notre étude s'est focalisée sur l'amodiaquine et ses principaux dérivés. Notre approche stratégique ainsi que les produits cibles du projet sont présentés, mettant en évidence des fonctions d'intérêt, susceptibles d'apporter la div

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8

Christie, Gary. "The role of disposition in drug immunogenicity." Thesis, University of Liverpool, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384515.

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9

Orrell, Catherine. "Artesunate and amodiaquine : tolerability and drug interaction study in healthy normal volunteers." Master's thesis, University of Cape Town, 2005. http://hdl.handle.net/11427/3295.

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10

Antinarelli, Luciana Maria Ribeiro. "Atividade leishmanicida de derivados de quinolinas: 4-aminoquinolinas complexadas a esteroide e amodiaquina." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/5289.

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Submitted by Renata Lopes (renatasil82@gmail.com) on 2017-06-21T15:25:14Z No. of bitstreams: 1 lucianamariaribeiroantinarelli.pdf: 3736513 bytes, checksum: 7a35a693236ba9e982e630b172b6f3cf (MD5)<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2017-08-07T19:10:52Z (GMT) No. of bitstreams: 1 lucianamariaribeiroantinarelli.pdf: 3736513 bytes, checksum: 7a35a693236ba9e982e630b172b6f3cf (MD5)<br>Made available in DSpace on 2017-08-07T19:10:52Z (GMT). No. of bitstreams: 1 lucianamariaribeiroantinarelli.pdf: 3736513 bytes, checksum: 7a35a693236ba9e982e630b

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11

Salentin, Sebastian, Melissa F. Adasme, Jörg C. Heinrich, et al. "From malaria to cancer: Computational drug repositioning of amodiaquine using PLIP interaction patterns." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230907.

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Drug repositioning identifies new indications for known drugs. Here we report repositioning of the malaria drug amodiaquine as a potential anti-cancer agent. While most repositioning efforts emerge through serendipity, we have devised a computational approach, which exploits interaction patterns shared between compounds. As a test case, we took the anti-viral drug brivudine (BVDU), which also has anti-cancer activity, and defined ten interaction patterns using our tool PLIP. These patterns characterise BVDU’s interaction with its target s. Using PLIP we performed an in silico screen of all str

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12

Scholtz, Jacques Coenraad. "Preparation, stability and in vitro evaluation of liposomes containing amodiaquine / Jacques C. Scholtz." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4878.

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Malaria is a curable disease that claims nearly one million lives each year. Problems with the treatment of malaria arise as resistance spreads and new treatment options are becoming less effective. The need for new treatments are of the utmost importance. Liposomes combined with antimalarials are a new avenue for research as liposomes can increase the efficacy of drugs against pathogens, as well as decreasing toxicity. Amodiaquine is a drug with known toxicity issues, but has proven to be effective and is, therefore, a prime candidate to be incorporated into the liposomal drug delivery system

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13

Harrison, Anthony Charles. "The effect of chemical modification on the metabolism of amodiaquine in the rat." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386776.

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14

Vaillant, Michel. "Déploiement d’une nouvelle stratégie de traitement d’une maladie à transmission vectorielle : application au paludisme, analyse des pratiques thérapeutiques, et conséquences sur l’épidémiologie de P. falciparum en Casamance, Sénégal, 1996 - 2009." Thesis, Bordeaux 2, 2010. http://www.theses.fr/2010BOR21804/document.

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Le paludisme demeure un des principaux fardeaux de l'humanité en dépit d'une évolution générale favorable du nombre de cas de paludisme. Les travaux contenus dans cette thèse concernent le déploiement d'une combinaison antipaludique à base de dérivés de l'artémisinine en zone rurale à transmission modérée. Le choix du traitement à adopter doit reposer sur l'évidence, dont la forme la plus aboutie demeure la revue systématique et méta-analyse. Cependant, la présentation des résultats peut être améliorée dans le but de faciliter la prise de décision. En outre pour compléter cette preuve expérime

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15

Delarue, Sandrine. "Conception, synthese et etude de l'activite antipaludique de derives 4-anilinoquinoleine." Lille 2, 2001. http://www.theses.fr/2001LIL2P256.

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16

O'Neill, Paul M. "The effect of chemical substitution on the metabolism and antimalarial activity of amodiaquine and primaquine." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261841.

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17

Kofoed, Poul-Erik. "Treatment of uncomplicated malaria in Guinea-Bissau /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-698-0/.

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18

Larrue, Philippe-Henri. "Les hépatites médicamenteuses à l'amodiaquine." Bordeaux 2, 1989. http://www.theses.fr/1989BOR25056.

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19

Anyorigiya, Thomas Atingane. "Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated Falciparum malaria." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27301.

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RATIONALE: The accurate measurement of antimalarial drug concentrations in key target patient groups is essential to ensure optimal dosing for malaria treatment and to distinguish between inadequate drug exposure and antimalarial resistance. METHODS: A sensitive and selective liquid chromatography-tandem mass spectrophotometric method was developed and validated for the simultaneous determination of amodiaquine and its active metabolite, desethylamodiaquine in 20μl heparinised human capillary whole blood and capillary plasma. During validation no significant matrix effects were observed for th

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20

SOE, AUNG PAING. "Treatment efficacy of artesunate-amodiaquine and prevalence of Plasmodium falciparum drug resistance markers in Zanzibar, 2002-2017." Thesis, Uppsala universitet, Internationell mödra- och barnhälsovård (IMCH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-373268.

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Introduction: Emergence of resistance to artemisinin-based combination therapy (ACT) is a major threat to combat Plasmodium falciparum malaria. Regular therapeutic studies to monitor treatment efficacy is essential, and genotyping of molecular makers is useful for mapping development and spread of resistance. Aims: The study aims are to assess efficacy of artesunate-amodiquine (ASAQ) and prevalence of molecular markers of drug resistance in Zanzibar in 2017. Methods: Treatment efficacy of the clinical trial conducted in 2017 was compared with efficacies in 2002 and 2005. A total of 142 samples

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21

Jacobs, Suesan, Amanda Vonderfecht, and Georg Wondrak. "Artemisinin-Based Combination Anti-malarials Do Not Enhance Anti-melanoma Activity of Artemisinin-Monotherapy." The University of Arizona, 2013. http://hdl.handle.net/10150/614262.

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Class of 2013 Abstract<br>Specific Aims: To determine if melanoma cells are more vulnerable to Amodiaquine (AQ) or Lumefantrine (LF)-based artemisinin combination therapy compared to artemisinin monotherapy. Methods: Tested anti-malarials in vitro for anti-melanoma activity, which contained 100,000 of the A375 human metastatic melanoma cells that were repeatedly treated independently three times. Main Results: Dihydroartemisinin (DHA) monotherapy induced significant cell death in melanoma cells. However, artemisinin combination therapy (ACT) did not enhance DHA-induced cell death. AQ prot

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22

Valente, Cristiane Oliveira. "Desenvolvimento de um biossensor a base de hemina para análise de amodiaquina em leite materno." Universidade Federal de Sergipe, 2010. https://ri.ufs.br/handle/riufs/6133.

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This research had as main objective to develop an electroanalytical procedure for the determination of amodiaquine in human milk, using a carbon paste electrode modified with hemin, hemoglobin functional group responsible for transporting oxygen. The amodiaquine (a derivative 4-aminoquinoquinolínico) is a drug used to treat malaria with anti-inflammatory and antipyretic properties. The characterization and preparation of carbon paste electrode modified with hemin was investigated. The electrochemical behavior of modified electrode was explored using differential pulse voltammetry. The best vo

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23

Mariga, Shelton Tendai. "Pharmacodynamic interactions of quinolines with other antimalarial compounds in vitro /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-279-9/.

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24

FADAT, GILLES. "Efficacite in vivo et in vitro de l'amodiaquine dans le traitement de l'acces palustre simple a plasmodium falciparum au cameroun (zone de chimioresistance a la chloroquine)." Lyon 1, 1991. http://www.theses.fr/1990LYO1M220.

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25

Hermelin-Jobet, Isabelle. "Recherche d'un métabolite inconnu de l'amopyroquine : étude de réactions biomimétiques." Paris 5, 1994. http://www.theses.fr/1994PA05P141.

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26

Zongo, Issaka. "Efficacy, safety, tolerability of Dihydroartemisinine-Piperaquine and Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention (SMC) in children in Burkina Faso." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2014. http://researchonline.lshtm.ac.uk/2026584/.

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Children in areas of highly seasonal malaria transmission in the Sahel should receive SMC with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ). These drugs retain their efficacy in the areas where SMC is recommended, but alternative regimens are needed if SMC is used in other areas or if these drugs start to lose efficacy. The aim of this study was to investigate the suitability of dihydroartemisin-piperaquine (DHAPQ) for SMC, using a non-inferiority trial design. 1500 children randomized to receive SPAQ or DHAPQ monthly from August to October, and a cohort of untreated children outside the

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27

Wessels, Johanna Christina. "International pharmacopoeia monographs : antimalarial dosage forms / J.C. Wessels." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4920.

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Malaria is a disease affecting millions of people in 109 malarious countries and territories, causing approximately one million deaths annually. In 2004 one of the parasites causing human malaria, Plasmodium falciparum, was among the leading global causes of death from a single infectious agent, especially in Africa (WHO, 2008:23). Treatment of this disease with single active pharmaceutical ingredients has led to the emergence of resistant P. falciparum parasites, resulting in the most severe form of this illness. Alarmingly, the poor quality of commercially available antimalarial products, es

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28

Kweku, Margaret Abena. "Impact of intermittent preventive treatment in children (IPTc) with amodiaquine (AQ) plus artesunate (AS) versus sulphadoxine-pyrimethamine (SP) alone on Haemoglobin levels and malaria morbidity in the Hohoe District of Ghana." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.582647.

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Malaria and anaemia are the leading cause of morbidity and mortality in children worldwide (WHO, 1986) and are the main disease burdens in sub-Saharan Africa. Severe malaria and anaemia are often fatal, while moderate anaemia in childhood is associated with impaired physical and mental development. One promising approach to the prevention of malaria is the administration of intermittent preventive treatment (IPT) to infants (IPTi) or to children under five years old (IPTc). This involves administration of a predefined number of treatment courses of antimalarial drugs at specified time interval

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29

Dicko, Alassane. "Le Traitement Intermittent Préventif comme stratégie de lutte contre le paludisme chez les enfants." Thesis, Bordeaux 2, 2010. http://www.theses.fr/2010BOR21767/document.

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Le paludisme est l’une des maladies infectieuses la plus fréquente au monde avec 40% de la population mondiale exposée. En dépit des stratégies actuelles de lutte notamment la prise en charge rapide des cas, l’utilisation de matériaux imprégnés et la pulvérisation intra domiciliaire d’insecticide, le paludisme reste une des premières causes de morbidité et de mortalité notamment en Afrique subsaharienne. Cette partie du monde totalise à elle seule plus de 90% des cas de décès par paludisme dont 88% chez les enfants de moins de moins de 5 ans. En absence de vaccin utilisable en santé publique,

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30

Kimbeni, Malongo Trésor. "Développement d'électrodes sélectives pour l'analyse de composés d'intérêt pharmaceutique: antipaludéens et halogénures." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210504.

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RESUME<p><p>Le travail de thèse porte sur le développement d’électrodes sélectives originales et performantes pour l’analyse de composés d’intérêt pharmaceutique. <p><p> La partie introductive traite des notions relatives à l’électrochimie mais également de notions sur les molécules médicamenteuses étudiées, en l’occurrence les principes antipaludéens et l’iode.<p><p> La partie expérimentale se subdivise en deux parties distinctes selon le type d’électrodes sélectives auxquelles font appel les techniques électrochimiques.<p><p> La première partie concerne l’élaboration, la caractérisation et l

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31

Lindegårdh, Niklas. "Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids." Doctoral thesis, Uppsala University, Analytical Chemistry, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3346.

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<p>This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper.</p><p>Methods for the determination of atovaquone (ATQ) in plasma, whole blood and capillary blood applied onto sampling paper were developed and validated. </p><p>Automated solid-phase extraction (SPE) and liquid chromatography (LC) with UV absorbance detection was used to quantify ATQ. Venous blood contained higher leve

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32

Gibhard, Liezl. "The effect of Pheroid™ technology on the bioavailability of quinoline-based anti-malarial compounds in primates." Thesis, North-West University, 2012. http://hdl.handle.net/10394/9025.

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Resistance against anti-malarial drugs remains one of the greatest obstacles to the effective control of malaria. The current first-line treatment regimen for uncomplicated P.falciparum malaria is based on artemisinin combination therapies (ACTs). However, reports of an increase in tolerance of the malaria parasite to artemisinins used in ACTs have alarmed the malaria community. The spread of artemisinin-resistant parasites would impact negatively on malaria control. Chloroquine and amodiaquine are 4-aminoquinolines. Chloroquine and amodiaquine were evaluated in a primate model by comparing t

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33

Mangou, François. "Résistance de Plasmodium Falciparum et de Plasmodium Berghei à quatre antimalariques à noyau quinoléine : intervention des mécanismes de détoxication par les cytochromes P450 et le glutathion et rôle du gène Pbmdr." Bordeaux 2, 1999. http://www.theses.fr/1999BOR28663.

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34

Ratsimbasoa, Claude Arsène. "Prise en charge du paludisme au niveau communautaire chez les enfants de moins de 5 ans : evaluation de la mise en œuvre de la nouvelle politique nationale." Thesis, Bordeaux 2, 2011. http://www.theses.fr/2011BOR21848/document.

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ContexteSi l’efficacité de la stratégie de prise en charge du paludisme au niveau communautaire n’est pas remise en cause à Madagascar, la mise en place de la nouvelle politique nationale incluant le remplacement de la chloroquine par la combinaison artésunate plus amodiaquine et l’introduction des tests de diagnostic rapide (TDR) dans la prise en charge des fièvres chez les enfants de moins de cinq ans suscite plusieurs inquiétudes. ObjectifsLe principal objectif de notre travail a été d’évaluer la stratégie de prise en charge des fièvres chez les enfants de moins de 5 ans au niveau communaut

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35

Wassilew, Nasstasja [Verfasser]. "Randomisierte, doppelblinde, Plazebo-kontrollierte Therapiestudie zu Sulphadoxin-Pyrimethamin allein und in Kombination mit Amodiaquin oder Artesunat bei unkomplizierter Malaria in Ghana / Nasstasja Wassilew." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1025087747/34.

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36

Sagara, Issaka. "Méthodes d'analyse statistique pour données répétées dans les essais cliniques : intérêts et applications au paludisme." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM5081/document.

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De nombreuses études cliniques ou interventions de lutte ont été faites ou sont en cours en Afrique pour la lutte contre le fléau du paludisme. En zone d'endémie, le paludisme est une maladie récurrente. La revue de littérature indique une application limitée des outils statistiques appropriés existants pour l'analyse des données récurrentes de paludisme. Nous avons mis en oeuvre des méthodes statistiques appropriées pour l'analyse des données répétées d'essais thérapeutiques de paludisme. Nous avons également étudié les mesures répétées d'hémoglobine lors du suivi de traitements antipaludique

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37

Godin, David Andrew. "Development of an UFLC/MS/MS method for the comparative analysis of oxytocin and artesunate-amodiaquine for validation of field detection systems." Thesis, 2016. https://hdl.handle.net/2144/19190.

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Spurious, falsely-labeled, falsified or counterfeit (SFFC) pharmaceuticals are a health concern that claims hundreds of thousands of lives annually1, a violation of intellectual property rights which cost legitimate companies billions2, and a low-risk high yield revenue stream for organized crime2. While ports of entry and border control points are the primary access control points for SFFC3,4, advances in field portable detection and equipment offers an increasingly effective method for the assessment of pharmaceuticals at regional centers and points of distribution. This is particularly im

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38

Ho, Nga T. "Multiplexed, affordable, and portable platform for real time quantification of counterfeit and substandard medicines." Thesis, 2016. https://hdl.handle.net/2144/17078.

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The World Health Organization estimates that about 10-30% of pharmaceuticals in the world are either substandard or counterfeit. The number is even higher in the developing countries. From a public health perspective, a key contributor to the development and proliferation drug resistant strains of infections, including tuberculosis (TB), malaria and other infections that are leading killers in resource limited settings is poor quality medicines. Most of the main causes are profit driven corruption in many pharmaceutical companies, the poor manufacture and quality control, and/or the inappropri

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39

Rezbach, Philipp Matthias [Verfasser]. "Kombination von Amodiaquin mit Artesunat im Vergleich zu Amodiaquin als Monotherapie für die Behandlung von Kindern mit unkomplizierter Malaria tropica in Lambaréné, Gabun / vorgelegt von Philipp Matthias Rezbach." 2004. http://d-nb.info/972207597/34.

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40

J-Lyn, Yvonne Knoo. "CYP2C8 polymorphisms among malaria patients in Guinea-Bissau." Master's thesis, 2008. http://hdl.handle.net/10400.1/840.

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Tese mest. , Gestão da Água e da Costa, 2008, Universidade do Algarve<br>Cytochrome P450 (CYP) 2C8 is the major enzyme responsible for the metabolism of many clinically important drugs including the antimalarial amodiaquine (AQ). This study investigated in 91 malaria-infected patients from Guinea-Bissau, the prevalence of CYP2C8 variants CYP2C8*2, CYP2C8*3 and CYP2C8*4, which may have important clinical implications for the efficacy and toxicity of amodiaquine. CYP2C8*2 and CYP2C8*3 alleles were found to be present in high frequencies in this population at 24% and 32%, respectively. Most of

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41

Pötschke, Marc Ulrich [Verfasser]. "Observierte vs. nicht-observierte Therapie der unkomplizierten Malaria tropica mit Artesunat und Amodiaquin bei Kleinkindern in Lambaréné, Gabun / vorgelegt von Marc Ulrich Pötschke." 2009. http://d-nb.info/998393819/34.

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42

Graupner, Jens [Verfasser]. "Wirksamkeit von Amodiaquin in der Behandlung von Falciparum Malaria in einem Gebiet mit hohem Niveau von Chloroquinresistenz in Nigeria / vorgelegt von Jens Graupner." 2008. http://d-nb.info/990577066/34.

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