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Journal articles on the topic 'Amodiaquine'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

&NA;. "Amodiaquine." Reactions Weekly &NA;, no. 536 (1995): 4. http://dx.doi.org/10.2165/00128415-199505360-00009.

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&NA;. "Amodiaquine." Reactions Weekly &NA;, no. 886 (2002): 6. http://dx.doi.org/10.2165/00128415-200208860-00013.

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&NA;. "Amodiaquine." Reactions Weekly &NA;, no. 1317 (2010): 12. http://dx.doi.org/10.2165/00128415-201013170-00031.

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4

Bloland, Peter B., and Trenton K. Ruebush. "Amodiaquine." Lancet 348, no. 9042 (1996): 1659–60. http://dx.doi.org/10.1016/s0140-6736(05)65723-6.

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Mariga, S. T., J. P. Gil, C. Sisowath, W. H. Wernsdorfer, and A. Björkman. "Synergism between Amodiaquine and Its Major Metabolite, Desethylamodiaquine, against Plasmodium falciparum In Vitro." Antimicrobial Agents and Chemotherapy 48, no. 11 (2004): 4089–96. http://dx.doi.org/10.1128/aac.48.11.4089-4096.2004.

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ABSTRACT The in vitro activity of the prodrug amodiaquine and its metabolite monodesethyl-amodiaquine has been studied for three strains of Plasmodium falciparum: LS-2, LS-3, and LS-1. Both compounds showed significant activity against all three strains; the activity of amodiaquine was slightly higher than that of the metabolite. By use of a checkerboard design, interaction studies with both compounds yielded evidence of significant synergism; means of the sums of the fractional inhibitory concentrations were 0.0392 to 0.0746 for strain LS-2, 0.1567 to 0.3102 for strain LS-3, and 0.025 to 0.33

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6

Sowunmi, Akintunde, Tunde Balogun, Grace O. Gbotosho, Christian T. Happi, Ahmed A. Adedeji, and Fatai A. Fehintola. "Activities of Amodiaquine, Artesunate, and Artesunate-Amodiaquine against Asexual- and Sexual-Stage Parasites in Falciparum Malaria in Children." Antimicrobial Agents and Chemotherapy 51, no. 5 (2007): 1694–99. http://dx.doi.org/10.1128/aac.00077-07.

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ABSTRACT The activities of amodiaquine, artesunate, and artesunate-amodiaquine against asexual- and sexual-stage parasites were evaluated in 360 Nigerian children with uncomplicated Plasmodium falciparum malaria randomized to the standard dose regimens of the three drugs/combination. Clinical recovery from illness occurred in all children. There were no significant differences in fever clearance times. Patients treated with artesunate or artesunate-amodiaquine had significantly shorter parasite clearance times (1.4 ± 0.5 days or 1.4 ± 0.6 days versus 3.2 ± 2.3 days, P = 0.0001) and lower gamet

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7

Tarning, Joel, Palang Chotsiri, Vincent Jullien, et al. "Population Pharmacokinetic and Pharmacodynamic Modeling of Amodiaquine and Desethylamodiaquine in Women with Plasmodium vivax Malaria during and after Pregnancy." Antimicrobial Agents and Chemotherapy 56, no. 11 (2012): 5764–73. http://dx.doi.org/10.1128/aac.01242-12.

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ABSTRACTAmodiaquine is effective for the treatment ofPlasmodium vivaxmalaria, but there is little information on the pharmacokinetic and pharmacodynamic properties of amodiaquine in pregnant women with malaria. This study evaluated the population pharmacokinetic and pharmacodynamic properties of amodiaquine and its biologically active metabolite, desethylamodiaquine, in pregnant women withP. vivaxinfection and again after delivery. Twenty-seven pregnant women infected withP. vivaxmalaria on the Thai-Myanmar border were treated with amodiaquine monotherapy (10 mg/kg/day) once daily for 3 days.

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Beshir, Khalid, Colin J. Sutherland, Ioannis Merinopoulos, et al. "Amodiaquine Resistance in Plasmodium falciparum Malaria in Afghanistan Is Associated with the pfcrt SVMNT Allele at Codons 72 to 76." Antimicrobial Agents and Chemotherapy 54, no. 9 (2010): 3714–16. http://dx.doi.org/10.1128/aac.00358-10.

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ABSTRACT Mutations in the Plasmodium falciparum genes pfcrt and pfmdr1 are selected by amodiaquine treatment in Africa. To examine the importance of these mutations in amodiaquine-treated Asian parasites, we determined pre- and posttreatment genotypes for amodiaquine treatment failures from a clinical trial in Afghanistan. The pfcrt codon 72 to 76 haplotype SVMNT was present in all samples tested, both before and after treatment. Amodiaquine did not clearly select for any pfmdr1 genotype, but a novel mutation, pfmdr1 N86F, was detected in four samples. We provide in vivo data to support the in

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Walimbwa, Stephen I., Mohammed Lamorde, Catriona Waitt, et al. "Drug Interactions between Dolutegravir and Artemether-Lumefantrine or Artesunate-Amodiaquine." Antimicrobial Agents and Chemotherapy 63, no. 2 (2018): e01310-18. http://dx.doi.org/10.1128/aac.01310-18.

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ABSTRACT Across sub-Saharan Africa, patients with HIV on antiretrovirals often get malaria and need cotreatment with artemisinin-containing therapies. We undertook two pharmacokinetic studies in healthy volunteers, using standard adult doses of artemether-lumefantrine or artesunate-amodiaquine given with 50 mg once daily dolutegravir (DTG) to investigate the drug-drug interaction between artemether-lumefantrine or artesunate-amodiaquine and dolutegravir. The dolutegravir/artemether-lumefantrine interaction was evaluated in a two-way crossover study and measured artemether, dihydroartemisinin,

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10

Gil, Jose Pedro. "Amodiaquine pharmacogenetics." Pharmacogenomics 9, no. 10 (2008): 1385–90. http://dx.doi.org/10.2217/14622416.9.10.1385.

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11

&NA;. "Artesunate/amodiaquine." Reactions Weekly &NA;, no. 1244 (2009): 7–8. http://dx.doi.org/10.2165/00128415-200912440-00019.

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12

Rijken, Marcus J., Rose McGready, Vincent Jullien, et al. "Pharmacokinetics of Amodiaquine and Desethylamodiaquine in Pregnant and Postpartum Women with Plasmodium vivax Malaria." Antimicrobial Agents and Chemotherapy 55, no. 9 (2011): 4338–42. http://dx.doi.org/10.1128/aac.00154-11.

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ABSTRACTIn order to study the pharmacokinetic properties of amodiaquine and desethylamodiaquine during pregnancy, 24 pregnant women in the second and third trimesters of pregnancy and withPlasmodium vivaxmalaria were treated with amodiaquine (10 mg/kg of body weight/day) for 3 days. The same women were studied again at 3 months postpartum. Plasma was analyzed for amodiaquine and desethylamodiaquine by use of a liquid chromatography-tandem mass spectrometry method. Individual concentration-time data were evaluated using noncompartmental analysis. There were no clinically relevant differences in

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Ubulom, Peace Mayen Edwin, Chinweizu Ejikeme Udobi, and Mark Iheukwumere Madu. "Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy." Journal of Tropical Medicine 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/947390.

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Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy.Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations againstPlasmodium berghei bergheiwas evaluated using Swiss albino mice.Results. Amodiaquine (a known antiplasmodial agent) had a fairly significant antiplasmodial effect reducing the parasites for every 100 red blood cells (RBC) from 66 to 16 (75.75%) at the tolerable dosage level of 7.5 mg/kg body weight while Ciprofloxacin (an antibiotic known to

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Adepiti, A. O., A. Adehin, O. Ogunlade, et al. "MAMA Decoction, Nigerian Herbal Antimalarial Preparation, Alters the Disposition of Amodiaquine in Healthy Humans." Nigerian Journal of Pharmaceutical Research 20, no. 1 (2024): 39–48. http://dx.doi.org/10.4314/njpr.v20i1.5.

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Background: MAMA Decoction (MD) is prepared from the leaves of Mangifera indica, Alstonia boonei, Morinda lucida and Azadirachta indica. A co-administration of MD with amodiaquine led to synergism in the clearance of malaria parasites in a previous report. The pharmacokinetic basis for this observation was the subject of another study in mice which found significant MD- induced increase in the exposure and half-life of desethylamodiaquine, the major metabolite of amodiaquine.Objective: This study aimed at evaluating previously identified murine herb-drug interactions in healthy human volunteer

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Jiang, Nianyu, and Pranav Shrotriya. "Low-Cost and Portable Biosensor Based on Monitoring Impedance Changes in Aptamer-Functionalized Nanoporous Anodized Aluminum Oxide Membrane." Micromachines 16, no. 1 (2024): 35. https://doi.org/10.3390/mi16010035.

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We report a low-cost, portable biosensor composed of an aptamer-functionalized nanoporous anodic aluminum oxide (NAAO) membrane and a commercial microcontroller chip-based impedance reader suitable for electrochemical impedance spectroscopy (EIS)-based sensing. The biosensor consists of two chambers separated by an aptamer-functionalized NAAO membrane, and the impedance reader is utilized to monitor transmembrane impedance changes. The biosensor is utilized to detect amodiaquine molecules using an amodiaquine-binding aptamer (OR7)-functionalized membrane. The aptamer-functionalized membrane is

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Salako, Kehinde S. "Screening of Amodiaquine for its in vitro Anti-cancer Activity on Breast Cancer Cell Lines- a Case Study for Drug Reprofiling." Pan African Journal of Life Sciences 5, no. 2 (2021): 263–73. http://dx.doi.org/10.36108/pajols/1202.50.0240.

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Background: Cancer is one of the foremost contributors to global disease bur den and constantly requires new therapeutic options. The development of new drugs has failed to keep up with its incidence. Hence, drug reprofiling strategies are emerging as novel therapeutic options. The study aimed to evaluate the anti-cancer activity of amodiaquine (anti-malarial drug) using a combination of murine and human breast cancer cell lines Methods: Amodiaquine was authenticated by ultra-violet spectrophotometry, high- performance liquid chromatography and 1D nuclear magnetic resonance. In vitro cytotoxic

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Ndung'u, Loise, Benard Langat, Esther Magiri, et al. "Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters." Wellcome Open Research 2 (June 20, 2017): 44. http://dx.doi.org/10.12688/wellcomeopenres.11768.1.

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Background: The human malaria parasite Plasmodium falciparum has evolved complex drug evasion mechanisms to all available antimalarials. To date, the combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria. In this combination, a short acting, artesunate is partnered with long acting, amodiaquine for which resistance may emerge rapidly especially in high transmission settings. Here, we used a rodent malaria parasite Plasmodium berghei ANKA as a surrogate of P. falciparum to investigate the mechanisms of amodiaquine resistance. Methods: We used s

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Chan, Xin Hui S., Ilsa L. Haeusler, Yan Naung Win, et al. "The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis." PLOS Medicine 18, no. 9 (2021): e1003766. http://dx.doi.org/10.1371/journal.pmed.1003766.

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Background Amodiaquine is a 4-aminoquinoline antimalarial similar to chloroquine that is used extensively for the treatment and prevention of malaria. Data on the cardiovascular effects of amodiaquine are scarce, although transient effects on cardiac electrophysiology (electrocardiographic QT interval prolongation and sinus bradycardia) have been observed. We conducted an individual patient data meta-analysis to characterise the cardiovascular effects of amodiaquine and thereby support development of risk minimisation measures to improve the safety of this important antimalarial. Methods and f

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Nath Saha, Chandra, Sanjib Bhattacharya, and Dipak Chetia. "Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity." E-Journal of Chemistry 6, s1 (2009): S381—S389. http://dx.doi.org/10.1155/2009/693757.

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Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to cellular macromolecules leading to hepatotoxicity and agranulocytosis. Interchange of the 3ʼ hydroxyl and the 4ʼ Mannich side-chain function of amodiaquine provides an amodiaquine regioisomer (isoquine) that cannot form toxic quinoneimine metabolites. By a simple two-step procedure, four isoquine analogues were synthesized and subsequently evaluat

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Kimera, Charles Lukanga. "A Randomized Clinical Trial Comparing Artesunate/Amodiaquine and Coartem in Treatment of Uncomplicated Malaria in Pregnancy in Mulago Hospital." Journal of Advance Research in Medical & Health Science (ISSN: 2208-2425) 5, no. 2 (2019): 01–13. http://dx.doi.org/10.53555/nnmhs.v5i2.599.

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BACKGROUND: The therapeutic efficacy and safety of artesunate plus amodiaquine and artemether/lumefantrine were assessed in Mulago hospital, Kampala, Uganda, an area with high levels of Plasmodium falciparum resistance to chloroquine and sulphadoxine-pyrimethamine. MATERIALS AND METHODS: A total of 369 pregnant mothers beyond the first trimester (>12 weeks) and less than 37 weeks of gestation with signs and symptoms of malaria were screened for malaria parasites. Of these, 109 had uncomplicated malaria infection with parasite density 200 to 200,000 parasites/?L and were enrolled following i

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Ruscoe, J. E., M. D. Tingle, P. M. O’Neill, S. A. Ward, and B. K. Park. "Effect of Disposition of Mannich Antimalarial Agents on Their Pharmacology and Toxicology." Antimicrobial Agents and Chemotherapy 42, no. 9 (1998): 2410–16. http://dx.doi.org/10.1128/aac.42.9.2410.

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ABSTRACT The use of the antimalarial agent amodiaquine has been curtailed due to drug-induced idiosyncratic reactions. These have been attributed to the formation of a protein-reactive quinoneimine species via oxidation of the 4-aminophenol group. Therefore, the effects of chemical modifications on the disposition of amodiaquine in relation to its metabolism, distribution, and pharmacological activity have been investigated. The inclusion of a group at the C-5′ position of amodiaquine reduced or eliminated bioactivation, as determined by glutathione conjugate formation in vivo. This can be see

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&NA;. "Artesunate/amodiaquine interaction." Reactions Weekly &NA;, no. 1141 (2007): 8. http://dx.doi.org/10.2165/00128415-200711410-00027.

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&NA;. "Amodiaquine/artesunate/metopimazine." Reactions Weekly &NA;, no. 1414 (2012): 10. http://dx.doi.org/10.2165/00128415-201214140-00025.

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LARREY, DOMINIQUE. "Amodiaquine-lnduced Hepatitis." Annals of Internal Medicine 104, no. 6 (1986): 801. http://dx.doi.org/10.7326/0003-4819-104-6-801.

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HIRSCHEL, B. "Amodiaquine and Hepatitis." Annals of Internal Medicine 105, no. 3 (1986): 467. http://dx.doi.org/10.7326/0003-4819-105-3-467_1.

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Bhattarai, Achuyt, Mita Maini-Thapar, Abdullah S. Ali, and Anders Björkman. "Amodiaquine during pregnancy." Lancet Infectious Diseases 4, no. 12 (2004): 721–22. http://dx.doi.org/10.1016/s1473-3099(04)01198-3.

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De la Hoz Restrepo, Fernando, Alexandra Porras Ramírez, Alejandro Rico Mendoza, Freddy Córdoba, and Diana Patricia Rojas. "Artesunate + amodiaquine versus artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in the Colombian Pacific region: a noninferiority trial." Revista da Sociedade Brasileira de Medicina Tropical 45, no. 6 (2012): 732–38. http://dx.doi.org/10.1590/s0037-86822012000600015.

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INTRODUCTION: In Colombia, there are no published studies for the treatment of uncomplicated Plasmodium falciparum malaria comparing artemisinin combination therapies. Hence, it is intended to demonstrate the non-inferior efficacy/safety profiles of artesunate + amodiaquine versus artemether-lumefantrine treatments. METHODS: A randomized, controlled, open-label, noninferiority (Δ≤5%) clinical trial was performed in adults with uncomplicated P. falciparum malaria using the 28‑day World Health Organization validated design/definitions. Patients were randomized 1:1 to either oral artesunate + amo

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Cairns, M., B. Cisse, C. Sokhna, et al. "Amodiaquine Dosage and Tolerability for Intermittent Preventive Treatment To Prevent Malaria in Children." Antimicrobial Agents and Chemotherapy 54, no. 3 (2010): 1265–74. http://dx.doi.org/10.1128/aac.01161-09.

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ABSTRACT Sulfadoxine-pyrimethamine with amodiaquine (SP-AQ) is a highly efficacious regimen for intermittent preventive treatment to prevent malaria in children (IPTc), but the amodiaquine component is not always well tolerated. We determined the association between amodiaquine dosage by body weight and mild adverse events (AEs) and investigated whether alternative age-based regimens could improve dosing accuracy and tolerability, using data from two trials of IPTc in Senegal, one in which AQ dose was determined by age and the other in which it was determined by weight category. Both dosage st

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Piñeros, Juan Gabriel, Mary Luz López, Jaime Carmona Fonseca, and Silvia Blair. "Liver and haematological safety of amodiaquine treatment in non-complicated falciparum malaria." Colombia Medica 37, no. 4 (2006): 258–65. http://dx.doi.org/10.25100/cm.v37i4.455.

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Background: At present there are few effective antimalarial drugs, amodiaquine is one of them; however, its use has been restricted by previous information about hematic and hepatic toxicity when it is administered as prophylactic at doses greater than 1,500 mg. But at therapeutic doses, the side effects are either slight or of moderate intensity and include nausea, vomit and pruritus. Objective: To evaluate the hepatic and hematic toxicity of amodiaquine administered at doses and time recommended for treatment of uncomplicated Plasmodium falciparum malaria. Methods: Longitudinal design with n

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Echerfaoui, Fouad, Houda Bouchafra, Khadija El Bourakadi, et al. "Development, Optimization, and Validation of a Novel HPLC Method for Simultaneous Quantification of Artesunate and Amodiaquine in Tablet Formulations." Methods and Objects of Chemical Analysis 18, no. 1 (2023): 42–50. http://dx.doi.org/10.17721/moca.2023.42-50.

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Artemisinin-based combination therapy (ACTs) has become the primary first-line treatment for mild falciparum malaria in the majority of African countries. A fixed-dose combination of amodiaquine and artesunate is commonly employed to enhance treatment compliance and achieve successful malaria outcomes. In this study, a specific, accurate, linear, precise, and repeatable method was optimized, verified, and applied for the simultaneous estimation of artesunate and amodiaquine HCl in a commercially available artesunate-amodiaquine tablet with a dosage of 100 mg/270 mg. The optimization process in

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Mak, Alastair, and Jack Uetrecht. "Immunization with amodiaquine-modified hepatic proteins prevents amodiaquine-induced liver injury." Journal of Immunotoxicology 12, no. 4 (2014): 361–67. http://dx.doi.org/10.3109/1547691x.2014.983660.

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Ndung'u, Loise, Benard Langat, Esther Magiri, et al. "Amodiaquine resistance in Plasmodium berghei is associated with PbCRT His95Pro mutation, loss of chloroquine, artemisinin and primaquine sensitivity, and high transcript levels of key transporters." Wellcome Open Research 2 (June 6, 2018): 44. http://dx.doi.org/10.12688/wellcomeopenres.11768.2.

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Background: The human malaria parasite Plasmodium falciparum has evolved drug evasion mechanisms to all available antimalarials. The combination of amodiaquine-artesunate is among the drug of choice for treatment of uncomplicated malaria. In this combination, a short-acting, artesunate is partnered with long-acting, amodiaquine for which resistance may emerge rapidly especially in high transmission settings. Here, we used a rodent malaria parasite Plasmodium berghei ANKA as a surrogate of P. falciparum to investigate the mechanisms of amodiaquine resistance. Methods: We used the ramp up approa

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Hawley, S. R., P. G. Bray, P. M. O'Neill, D. J. Naisbitt, B. K. Park, and S. A. Ward. "Manipulation of the N-alkyl substituent in amodiaquine to overcome the verapamil-sensitive chloroquine resistance component." Antimicrobial Agents and Chemotherapy 40, no. 10 (1996): 2345–49. http://dx.doi.org/10.1128/aac.40.10.2345.

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Aminoquinoline resistance correlates with lipid solubility at pH 7.2. Consequently, the in vivo dealkylation of amodiaquine, to the less lipid-soluble desethylamodiaquine, is a likely contributor to therapeutic failure in vivo. Therefore, 4-aminoquinoline drugs with lipid solubilities similar to that of amodiaquine, but which are not subject to side chain modification in vivo, should be superior antimalarial agents. In this study, we have identified amopyroquine and N-tertbutylamodiaquine as two such compounds. The values for the logarithms of the partition coefficients for amopyroquine and N-

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Arise, Rotimi Olusanya, Sunday-Nwaso Elizabeth, Samuel Tobi Farohunbi, Mikhail Olugbemiro Nafiu, and Adedibu Clement Tella. "Mechanochemical Synthesis, In vivo Anti-malarial and Safety Evaluation of Amodiaquine-zinc Complex." Acta Facultatis Medicae Naissensis 34, no. 3 (2017): 221–33. http://dx.doi.org/10.1515/afmnai-2017-0024.

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Summary So far, some prospective metal-based anti-malarial drugs have been developed. The mechanochemical synthesis and characterization of Zn (II) complex with amodiaquine and its anti-malarial efficacy on Plasmodium berghei-infected mice and safety evaluation were described in this study. Solvent-free mechanochemical synthesis and characterization of Zn (II) complex with amodiaquine as well as its anti-malarial efficacy on NK-65 Plasmodium berghei-infected mice and safety were evaluated. Derivatization of amodiaquine with zinc (II) ion enhanced the activity of the drug through significant (p

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Liu, Yun, Chaoying Hu, Gangyi Liu, et al. "A Replicate Designed Bioequivalence Study To Compare Two Fixed-Dose Combination Products of Artesunate and Amodiaquine in Healthy Chinese Volunteers." Antimicrobial Agents and Chemotherapy 58, no. 10 (2014): 6009–15. http://dx.doi.org/10.1128/aac.02617-14.

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ABSTRACTArtesun-Plus is a fixed-dose combination antimalarial agent containing artesunate and amodiaquine. The current study was conducted to compare the pharmacokinetic and safety profiles of Artesun-Plus and the WHO-designated comparator product Artesunate Amodiaquine Winthrop. To overcome the high intrasubject variability of artesunate, the study applied a two-sequence and four-period crossover (2 by 4), replicate study design to assess bioequivalence between the two products in 31 healthy male Chinese volunteers under fasting conditions. The results showed that the values of the geometric

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Tatura, Suryadi Nicolaas Napoleon. "Efikasi Obat Kloroquine, Kina, Artesunate-SP, Artesunate-Amodiaquine, Artesunate-Lumafentrin pada Anak Malaria Falciparum di BLU RSUP Prof. Dr. RD. Kandou Manado." Sari Pediatri 10, no. 6 (2016): 417. http://dx.doi.org/10.14238/sp10.6.2009.417-23.

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Latar belakang. Malaria falciparum masih merupakan salah satu penyebab utama kematian dan kesakitan pada anak-anak dan orang dewasa di negara-negara tropis. Di Indonesia, dilaporkan Plasmodium falciparum telsh resisten terhadap obat – obat anti malaria, terutama kemungkinan terjadi early treatment failure (ETF).Tujuan. Untuk mengetahui efikasi dan early treatment failure (ETF) obat anti malaria (OAM) yaitu kloroquin (CQ), kina, artesunat-SP(AS-SP), dan artesunate-amodiaquin(AS-AQ) serta artesunate- lumafentrin(AS-L) pada anak dengan malaria falciparum.Metode. Penelitian deskriptif retrospektif

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Rouveix, B., L. Coulombel, J. P. Aymard, F. Chau, and L. Abel. "Amodiaquine-induced immune agranulocytosis." British Journal of Haematology 71, no. 1 (1989): 7–11. http://dx.doi.org/10.1111/j.1365-2141.1989.tb06266.x.

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Bernuau, Jacques, Dominique Larrey, Bernard Campillo, et al. "Amodiaquine-induced fulminant hepatitis." Journal of Hepatology 6, no. 1 (1988): 109–12. http://dx.doi.org/10.1016/s0168-8278(88)80469-0.

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Malongo, T. Kimbeni, B. Blankert, O. Kambu, K. Amighi, J. Nsangu, and J. M. Kauffmann. "Amodiaquine polymeric membrane electrode." Journal of Pharmaceutical and Biomedical Analysis 41, no. 1 (2006): 70–76. http://dx.doi.org/10.1016/j.jpba.2005.10.014.

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Carr, R. "NEUTROPENIA AND PROPHYLACTIC AMODIAQUINE." Lancet 327, no. 8480 (1986): 556–57. http://dx.doi.org/10.1016/s0140-6736(86)90908-6.

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Rieckmann, Karl H. "Amodiaquine in malaria treatment." Transactions of the Royal Society of Tropical Medicine and Hygiene 81, no. 6 (1987): 1040. http://dx.doi.org/10.1016/0035-9203(87)90392-0.

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White, Nicholas J. "Can amodiaquine be resurrected?" Lancet 348, no. 9036 (1996): 1184–85. http://dx.doi.org/10.1016/s0140-6736(05)65475-x.

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White, NJ, S. Looareesuwan, G. Edwards, et al. "Pharmacokinetics of intravenous amodiaquine." British Journal of Clinical Pharmacology 23, no. 2 (1987): 127–35. http://dx.doi.org/10.1111/j.1365-2125.1987.tb03020.x.

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Peto, T. E. A., and C. F. Gilks. "Amodiaquine and malaria prophylaxis." Parasitology Today 2, no. 8 (1986): 209–11. http://dx.doi.org/10.1016/0169-4758(86)90083-9.

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Ehrhardt, Stephan, Teunis A. Eggelte, Sarah Kaiser, et al. "Large-Scale Surveillance of Plasmodium falciparum crt(K76T) in Northern Ghana." Antimicrobial Agents and Chemotherapy 51, no. 9 (2007): 3407–9. http://dx.doi.org/10.1128/aac.00179-07.

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ABSTRACT Surveillance of Plasmodium falciparum crt(K76T) [Pfcrt(K76T)], a resistance marker of chloroquine and, limitedly, amodiaquine, in >4,000 children in northern Ghana revealed a prevalence of 79%. Pfcrt(K76T) was heterogeneously distributed and associated with chloroquine use, low parasitemia, and the dry season. Widespread chloroquine resistance challenges the regional life span of amodiaquine as a partner drug in artemisinin combination therapy.

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Nsobya, Samuel L., Christian Dokomajilar, Moses Joloba, Grant Dorsey, and Philip J. Rosenthal. "Resistance-Mediating Plasmodium falciparum pfcrt and pfmdr1 Alleles after Treatment with Artesunate-Amodiaquine in Uganda." Antimicrobial Agents and Chemotherapy 51, no. 8 (2007): 3023–25. http://dx.doi.org/10.1128/aac.00012-07.

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ABSTRACT Key parasite polymorphisms were assessed in subjects treated for malaria with artesunate-amodiaquine in Tororo, Uganda. For pfcrt, all of the isolates tested had the CVIET haplotype. For pfmdr1, 86Y and 1246Y were common at baseline and their prevalences were significantly higher in new isolates after therapy, indicating that treatment selected for mutations associated with a decreased response to amodiaquine.

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Kawuma, Aida N., Stephen I. Walimbwa, Goonaseelan (Colin) Pillai, et al. "Dolutegravir pharmacokinetics during co-administration with either artemether/lumefantrine or artesunate/amodiaquine." Journal of Antimicrobial Chemotherapy 76, no. 5 (2021): 1269–72. http://dx.doi.org/10.1093/jac/dkab022.

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Abstract Background In sub-Saharan Africa, artemisinin-containing therapies for malaria treatment are regularly co-administered with ART. Currently, dolutegravir-based regimens are recommended as first-line therapy for HIV across most of Africa. Objectives To investigate the population pharmacokinetics of dolutegravir during co-administration with artemether/lumefantrine or artesunate/amodiaquine, two commonly used antimalarial therapies. Methods We developed a population pharmacokinetic model of dolutegravir with data from 26 healthy volunteers in two Phase 2 studies with a total of 403 dolut

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Ajeigbe, Kazeem O., Benjamin O. Emikpe, and Samuel Babafemi Olaleye. "Effects of artemisinin, with or without lumefantrine and amodiaquine on gastric ulcer healing in rat." Journal of Basic and Clinical Physiology and Pharmacology 29, no. 5 (2018): 515–24. http://dx.doi.org/10.1515/jbcpp-2017-0145.

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Abstract Background Antimalarial drugs have been shown to predispose the stomach to ulceration in rats. However, their role in the modulation of gastric ulcer healing is not known. The aim of the present study is to investigate the effect of artemisinin-based combination therapies on ulcer healing. Methods Gastric kissing ulcers were induced in 40 male albino rats (150–180 g) using 0.2 mL 50% acetic acid. One day after the ulcer induction, experimental rats were divided into four groups and treated once daily orally for 3 days as follows: (1) normal saline, (2) artemether-lumefantrine (2/12 mg

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Akpalu, Jr., A. K., P. K. Nyame, and A. N. O. Dodoo. "Amodiaquine-induced dystonic reactions: Case reports and implications for policy change in Ghana." International Journal of Risk & Safety in Medicine 17, no. 1-2 (2005): 1–4. https://doi.org/10.3233/jrs-2005-327.

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Ten cases of amodiaquine-induced dystonic reactions observed in a single ward in Ghana's Premier Teaching Hospital, over a period of 4 years are presented. All the reactions resolved without sequalae on treatment with diazepam and benztropine. The importance of increased safety monitoring of amodiaquine as it is (in combination with artesunate) introduced as first line treatment for uncomplicated malaria in Ghana is highlighted.

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Popoola, AbdulGafar N., and Innocent O. Imosemi. "Sub-acute evaluation of artesunate, amodiaquine and their combination on muscular coordination and morphology of the cerebellum of Wistar rats." International Journal of Biological and Chemical Sciences 14, no. 5 (2020): 1498–510. http://dx.doi.org/10.4314/ijbcs.v14i5.1.

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Artemisinin Combination Therapy (ACT) is currently the best choice for the treatment of malaria. Artesunate-amodiaquine combination is one of the most commonly used ACTs in Nigeria with a very potent efficacy but not without side effects involving motor coordination. Currently, there is dearth of information on its sub-acute effect on the cerebellum. This study investigated the sub-acute effects of artesunate (AS), amodiaquine (AQ) and artesunate + amodiaquine combination (AS+AQ) on the motor coordination, oxidative markers and morphology of the cerebellum of adult Wistar rats. Forty adult mal

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